村田　拓哉 (ムラタ　タクヤ)

研究者情報

所属

• 薬学部 講師
• 大学院薬学研究科 講師

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201901008492009047

J-Global ID

• 201901008492009047

研究分野

• ライフサイエンス / 分子生物学

経歴

• 2022年05月 - 現在  帝京大学薬学部講師
• 2011年04月 - 2022年04月  帝京大学薬学部助教

学歴

• 2006年04月 - 2011年03月   東京大学大学院   農学生命科学研究科
• 2002年04月 - 2006年03月   東京大学   理学部   化学科

研究活動情報

論文

• Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency.

  Takuya Murata; Genta Ito; Naoko Utsunomiya-Tate

  Biochemical and biophysical research communications 654 18 - 25 2023年04月 [査読有り]
  
• A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

  Waka Sato; Miho Watanabe-Takahashi; Takuya Murata; Naoko Utsunomiya-Tate; Jun Motoyama; Masataka Anzai; Seiko Ishihara; Nanako Nishioka; Hina Uchiyama; Juri Togashi; Saeka Nishihara; Kiyoshi Kawasaki; Takashi Saito; Takaomi C. Saido; Satoru Funamoto; Kiyotaka Nishikawa

  Communications Biology 6 1 2023年04月 [査読有り]
  
• Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.

  Takuya Murata; Naoya Tochio; Naoko Utsunomiya-Tate

  Neuroscience letters 760 136077 - 136077 2021年08月 [査読有り]
  
• The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions.

  Takuya Murata; Yuka Unno; Mitsunori Fukuda; Naoko Utsunomiya-Tate

  Biochemistry and biophysics reports 23 100776 - 100776 2020年09月 [査読有り]
  
• Effect of site-specific amino acid D-isomerization on β-sheet transition and fibril formation profiles of Tau microtubule-binding repeat peptides.

  Tochio N; Murata T; Utsunomiya-Tate N

  Biochemical and biophysical research communications 508 1 184 - 190 2019年01月 [査読有り]
  
• Correction: "Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system" [Molecular and Cellular Biology, 29, 4, (2009), (1017-1034)] doi 10.1128/MCB.02123-07

  Yue Zhao; Ken-Ichi Takeyama; Shun Sawatsubashi; Saya Ito; Eriko Suzuki; Kaoru Yamagata; Masahiko Tanabe; Shuhei Kimura; Sally Fujiyama; Takashi Ueda; Takuya Murata; Hiroyuki Matsukawa; Yuko Shirode; Alexander P. Kouzmenko; Feng Li; Testuya Tabata; Shigeaki Kato

  Molecular and Cellular Biology 37 18 2017年09月 [査読有り]
  
• Corepressive Action of CBP on Androgen Receptor Transactivation in Pericentric Heterochromatin in a Drosophila Experimental Model System (vol 29, pg 1017, 2009)

  Yue Zhao; Ken-ichi Takeyama; Shun Sawatsubashi; Saya Ito; Eriko Suzuki; Kaoru Yamagata; Masahiko Tanabe; Shuhei Kimura; Sally Fujiyama; Takashi Ueda; Takuya Murata; Hiroyuki Matsukawa; Yuko Shirode; Alexander P. Kouzmenko; Feng Li; Testuya Tabata; Shigeaki Kato

  MOLECULAR AND CELLULAR BIOLOGY 37 18 2017年09月 [査読有り]
  
• Epigenetic Silencing of Core Histone Genes by HERS in Drosophila

  Saya Ito; Sally Fujiyama-Nakamura; Shuhei Kimura; Jinseon Lim; Yuki Kamoshida; Yumi Shiozaki-Sato; Shun Sawatsubashi; Eriko Suzuki; Masahiko Tanabe; Takashi Ueda; Takuya Murata; Hiromi Kato; Fumiaki Ohtake; Ryoji Fujiki; Tsuneharu Miki; Alexander Kouzmenko; Ken-ichi Takeyama; Shigeaki Kato

  MOLECULAR CELL 45 4 494 - 504 2012年02月 [査読有り]
  
• A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor

  Shun Sawatsubashi; Takuya Murata; Jinseon Lim; Ryoji Fujiki; Saya Ito; Eriko Suzuki; Masahiko Tanabe; Yue Zhao; Shuhei Kimura; Sally Fujiyama; Takashi Ueda; Daiki Umetsu; Takashi Ito; Ken-ichi Takeyama; Shigeaki Kato

  GENES & DEVELOPMENT 24 2 159 - 170 2010年01月 [査読有り]
  
• Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor (Retracted article. See vol. 54, pg. 536, 2014)

  Kaoru Yamagata; Sally Fujiyama; Saya Ito; Takashi Ueda; Takuya Murata; Masanori Naitou; Ken-ichi Takeyama; Yasuhiro Minami; Bert W. O'Malley; Shigeaki Kato

  MOLECULAR CELL 36 2 340 - 347 2009年10月 [査読有り]
  
• BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex

  Sally Fujiyama-Nakamura; Saya Ito; Shun Sawatsubashi; Yoshio Yamauchi; Eriko Suzuki; Masahiko Tanabe; Shuhei Kimura; Takuya Murata; Toshiaki Isobe; Ken-ichi Takeyama; Shigeaki Kato

  GENES TO CELLS 14 8 965 - 973 2009年08月 [査読有り]
  
• Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity

  Eriko Suzuki; Yue Zhao; Saya Ito; Shun Sawatsubashi; Takuya Murata; Takashi Furutani; Yuko Shirode; Kaoru Yamagata; Masahiko Tanabe; Shuhei Kimura; Takashi Ueda; Sally Fujiyama; Jinseon Lim; Hiroyuki Matsukawa; Alexander P. Kouzmenko; Toshiro Aigaki; Tetsuya Tabata; Ken-ichi Takeyama; Shigeaki Kato

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 10 3818 - 3822 2009年03月 [査読有り]
  
• Corepressive Action of CBP on Androgen Receptor Transactivation in Pericentric Heterochromatin in a Drosophila Experimental Model System

  Yue Zhao; Ken-ichi Takeyama; Shun Sawatsubashi; Saya Ito; Eriko Suzuki; Kaoru Yamagata; Masahiko Tanabe; Shuhei Kimura; Sally Fujiyama; Takashi Ueda; Takuya Murata; Hiroyuki Matsukawa; Yuko Shirode; Alexander P. Kouzmenko; Feng Li; Testuya Tabata; Shigeaki Kato

  MOLECULAR AND CELLULAR BIOLOGY 29 4 1017 - 1034 2009年02月 [査読有り]
  
• RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila

  Takuya Murata; Eriko Suzuki; Saya Ito; Shun Sawatsubashi; Yue Zhao; Kaoru Yamagata; Masahiko Tanabe; Sally Fujiyama; Shuhei Kimura; Takashi Ueda; Hiroyuki Matsukawa; Alexander Kouzmenko; Takashi Furutani; Erina Kuranaga; Masayuki Miura; Ken-ichi Takeyama; Shigeaki Kato

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 72 9 2255 - 2261 2008年09月 [査読有り]
  
• Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor

  Shuhei Kimura; Shun Sawatsubashi; Saya Ito; Alexander Kouzmenko; Eriko Suzuki; Yue Zhao; Kaoru Yamagata; Masahiko Tanabe; Takashi Ueda; Sari Fujiyama; Takuya Murata; Hiroyuki Matsukawa; Ken-ichi Takeyama; Nobuo Yaegashi; Shigeaki Kato

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 371 4 889 - 893 2008年07月 [査読有り]
  

受賞

• 2009年03月 日本農芸化学会 BBB論文賞
   

  受賞者: 村田拓哉

共同研究・競争的資金等の研究課題

• 血球分化を制御するクロマチン構造調節転写複合体の同定とその機能解析

  日本学術振興会：科学研究費助成事業

  研究期間 : 2012年04月 -2014年03月 

  代表者 : 村田 拓哉