青木　直哉 (アオキ　ナオヤ)

研究者情報

所属

• 薬学部 准教授
• 大学院薬学研究科 准教授

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201401090187919417

J-Global ID

• 201401090187919417

研究キーワード

• アセチルコリン   GABA   学習臨界期   刻印付け   

研究分野

• ライフサイエンス / 薬系衛生、生物化学

経歴

• 2019年04月 - 現在  帝京大学薬学部准教授
• 2015年10月 - 2019年03月  帝京大学薬学部講師
• 2010年04月 - 2015年09月  帝京大学薬学部助教
• 2007年07月 - 2010年03月  独立行政法人理化学研究所脳科学総合研究センター研究員
• 2006年04月 - 2007年06月  ミネソタ大学神経科学部研究員

学歴

• 2006年03月 -   名古屋大学大学院   生命農学研究科 博士課程修了、農学博士

所属学協会

• 北米神経科学会   日本神経科学学会   

研究活動情報

論文

• Molecular characterization of chicken DA systems reveals that the avian personality gene, DRD4, is expressed in the mitral cells of the olfactory bulb

  Toshiyuki Fujita; Naoya Aoki; Chihiro Mori; Koichi J. Homma; Shinji Yamaguchi

  Frontiers in Neuroanatomy 19 2025年01月
• Perihatch surge of thyroid hormone drives cognitive flexibility in newborn chicks

  Naoya Aoki; Chihiro Mori; Shouta Serizawa; Toshiyuki Fujita; Shinji Yamaguchi; Koichi J. Homma

  Science Advances 10 41 2024年10月 [査読有り]
  
• SoxC and MmpReg promote blastema formation in whole-body regeneration of fragmenting potworms Enchytraeus japonensis

  Toshiyuki Fujita; Naoya Aoki; Chihiro Mori; Koichi J. Homma; Shinji Yamaguchi

  Nature Communications 15 1 2024年08月
• Molecular biology of serotonergic systems in avian brains

  Toshiyuki Fujita; Naoya Aoki; Chihiro Mori; Koichi J. Homma; Shinji Yamaguchi

  Frontiers in Molecular Neuroscience 16 2023年07月
• Temporal hampering of thyroid hormone synthesis just before hatching impeded the filial imprinting in domestic chicks.

  Shouta Serizawa; Naoya Aoki; Chihiro Mori; Toshiyuki Fujita; Shinji Yamaguchi; Toshiya Matsushima; Koichi J Homma

  Frontiers in physiology 14 1084816 - 1084816 2023年 [査読有り]
  
• Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes

  Toshiyuki Fujita; Naoya Aoki; Chihiro Mori; Shouta Serizawa; Fumiko Kihara-Negishi; Koichi J. Homma; Shinji Yamaguchi

  Frontiers in Physiology 13 2022年11月
• Subtype-selective contribution of muscarinic acetylcholine receptors for filial imprinting in newly-hatched domestic chicks.

  Naoya Aoki; Chihiro Mori; Toshiyuki Fujita; Shouta Serizawa; Shinji Yamaguchi; Toshiya Matsushima; Koichi J Homma

  Behavioural brain research 424 113789 - 113789 2022年04月 [査読有り]
  
• Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc.

  Naoya Aoki; Chihiro Mori; Toshiyuki Fujita; Shouta Serizawa; Shinji Yamaguchi; Toshiya Matsushima; Koichi J Homma

  Frontiers in physiology 13 822638 - 822638 2022年03月 [査読有り]
  
• Gene expression profiles of the muscarinic acetylcholine receptors in brain regions relating to filial imprinting of newly-hatched domestic chicks.

  Chihiro Mori; Naoya Aoki; Toshiyuki Fujita; Shinji Yamaguchi; Toshiya Matsushima; Koichi J Homma

  Behavioural brain research 420 113708 - 113708 2022年02月 [査読有り]
  
• Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes.

  Toshiyuki Fujita; Naoya Aoki; Chihiro Mori; Eiko Fujita; Toshiya Matsushima; Koichi J Homma; Shinji Yamaguchi

  Frontiers in physiology 13 882633 - 882633 2022年 [査読有り]
  
• Suppressive Modulation of the Chick Forebrain Network for Imprinting by Thyroid Hormone: An in Vitro Study.

  Yuriko Saheki; Naoya Aoki; Koichi J Homma; Toshiya Matsushima

  Frontiers in physiology 13 881947 - 881947 2022年 [査読有り]
  
• Serotonergic Neurons in the Chick Brainstem Express Various Serotonin Receptor Subfamily Genes.

  Toshiyuki Fujita; Naoya Aoki; Chihiro Mori; Eiko Fujita; Toshiya Matsushima; Koichi J Homma; Shinji Yamaguchi

  Frontiers in physiology 12 815997 - 815997 2021年 [査読有り]
  
• The dorsal arcopallium of chicks displays the expression of orthologs of mammalian fear related serotonin receptor subfamily genes.

  Toshiyuki Fujita; Naoya Aoki; Chihiro Mori; Eiko Fujita; Toshiya Matsushima; Koichi J Homma; Shinji Yamaguchi

  Scientific reports 10 1 21183 - 21183 2020年12月 [査読有り]
  
• Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus Gallus domesticus).

  Naoya Aoki; Toshiyuki Fujita; Chihiro Mori; Eiko Fujita; Shinji Yamaguchi; Toshiya Matsushima; Koichi J Homma

  Behavioural brain research 379 112291 - 112291 2020年02月 [査読有り]
  
• The chick pallium displays divergent expression patterns of chick orthologues of mammalian neocortical deep layer-specific genes

  Fujita T; Aoki N; Fujita E; Matsushima T; Homma KJ; Yamaguchi S

  Scientific Reports 9 1 20400 - 20400 2019年 [査読有り]
  
• GABA-A and GABA-B Receptors in Filial Imprinting Linked With Opening and Closing of the Sensitive Period in Domestic Chicks (Gallus gallus domesticus).

  Aoki N; Yamaguchi S; Fujita T; Mori C; Fujita E; Matsushima T; Homma KJ

  Frontiers in physiology 9 1837  2018年12月 [査読有り]
  
• Thyroid Hormone Sensitizes the Imprinting-Associated Induction of Biological Motion Preference in Domestic Chicks

  Miura M; Aoki N; Yamaguchi S; Homma KJ; Matsushima T

  Frontiers in Physiology 9 1740  2018年12月 [査読有り]
  
• Gene expression of Dio2 (thyroid hormone converting enzyme) in telencephalon is linked with predisposed biological motion preference in domestic chicks.

  Takemura Y; Yamaguchi S; Aoki N; Miura M; Homma KJ; Matsushima T

  Behavioural brain research 349 25 - 30 2018年09月 [査読有り]
  
• Wnt-2b in the intermediate hyperpallium apicale of the telencephalon is critical for the thyroid hormone-mediated opening of the sensitive period for filial imprinting in domestic chicks (Gallus gallus domesticus)

  Shinji Yamaguchi; Naoya Aoki; Toshiya Matsushima; Koichi J. Homma

  Hormones and Behavior 102 120 - 128 2018年06月 [査読有り]
  
• Sex Differences in Brain Thyroid Hormone Levels during Early Post-Hatching Development in Zebra Finch (Taeniopygia guttata)

  Shinji Yamaguchi; Shin Hayase; Naoya Aoki; Akihiko Takehara; Jun Ishigohoka; Toshiya Matsushima; Kazuhiro Wada; Koichi J. Homma

  PLOS ONE 12 1 e0169643  2017年01月 [査読有り]
  
• Involvement of nucleotide diphosphate kinase 2 in the reopening of the sensitive period of filial imprinting of domestic chicks (Gallus gallus domesticus)

  Shinji Yamaguchi; Naoya Aoki; Akihiko Takehara; Masaru Mori; Akio Kanai; Toshiya Matsushima; Koichi J. Homma

  NEUROSCIENCE LETTERS 612 32 - 37 2016年01月 [査読有り]
  
• CRITICAL ROLE OF THE NEURAL PATHWAY FROM THE INTERMEDIATE MEDIAL MESOPALLIUM TO THE INTERMEDIATE HYPERPALLIUM APICALE IN FILIAL IMPRINTING OF DOMESTIC CHICKS (GALLUS GALLUS DOMESTICUS)

  N. Aoki; S. Yamaguchi; T. Kitajima; A. Takehara; S. Katagiri-Nakagawa; R. Matsui; D. Watanabe; T. Matsushima; K. J. Homma

  NEUROSCIENCE 308 115 - 124 2015年11月 [査読有り]
  
• Potential Role of Voltage-Sensing Phosphatases in Regulation of Cell Structure Through the Production of PI(3,4)P-2

  Shinji Yamaguchi; Tatsuki Kurokawa; Ikuko Taira; Naoya Aoki; Souhei Sakata; Yasushi Okamura; Koichi J. Homma

  JOURNAL OF CELLULAR PHYSIOLOGY 229 4 422 - 433 2014年04月 [査読有り]
  
• Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum

  Shinji Yamaguchi; Naoya Aoki; Takaaki Kitajima; Yasushi Okamura; Koichi J Homma

  Communicative and Integrative Biology 7 5 2014年 [査読有り]
  
• [A primer for learning: thyroid hormone is a determining factor to start the sensitive period of filial imprinting of domestic chicks].

  Homma KJ; Yamaguchi S; Aoki N

  Seikagaku. The Journal of Japanese Biochemical Society 85 315 - 327 5 2013年05月 [査読有り]
  
• Insect Homologs of Papain

  Koichi J. Homma; Shinji Yamaguchi; Naoya Aoki

  Handbook of Proteolytic Enzymes 2 1963 - 1968 2013年 [査読有り]
  
• Thyroid hormone determines the start of the sensitive period of imprinting and primes later learning

  Shinji Yamaguchi; Naoya Aoki; Takaaki Kitajima; Eiji Iikubo; Sachiko Katagiri; Toshiya Matsushima; Koichi J. Homma

  NATURE COMMUNICATIONS 3 1081  2012年09月 [査読有り]
  
• Unusual Features of Chick VSP and its Potential Role in Regulation of Cell Structure

  Yasushi Okamura; Tatsuki Kurokawa; Shinji Yamaguchi; Naoya Aoki; Ikuko Taira; Souhei Sakata; Koichi Homma

  BIOPHYSICAL JOURNAL 102 3 37A - 37A 2012年01月 [査読有り]
  
• Identification of single neurons in a forebrain network

  Nancy F. Day; Stephen J. Kerrigan; Naoya Aoki; Teresa A. Nick

  JOURNAL OF NEUROPHYSIOLOGY 106 6 3205 - 3215 2011年12月 [査読有り]
  
• Activation of brain-derived neurotrophic factor/tropomyosin-related kinase B signaling accompanying filial imprinting in domestic chicks (Gallus gallus domesticus)

  Shinji Yamaguchi; Naoya Aoki; Daisuke Kobayashi; Takaaki Kitajima; Eiji Iikubo; Sachiko Katagiri; Toshiya Matsushima; Koichi J. Homma

  NEUROREPORT 22 17 929 - 934 2011年12月 [査読有り]
  
• Molecular function of microtubule-associated protein 2 for filial imprinting in domestic chicks (Gallus gallus domesticus)

  Shinji Yamaguchi; Sachiko Katagiri; Naoya Aoki; Eiji Iikubo; Takaaki Kitajima; Toshiya Matsushima; Koichi J. Homma

  NEUROSCIENCE RESEARCH 69 1 32 - 40 2011年01月 [査読有り]
  
• Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chicks (Gallus gallus domesticus)

  Shinji Yamaguchi; Ikuko Fujii-Taira; Akio Murakami; Naoki Hirose; Naoya Aoki; Ei-Ichi Izawa; Yasuyuki Fujimoto; Tatsuya Takano; Toshiya Matsushima; Koichi J. Homma

  BRAIN RESEARCH BULLETIN 76 3 282 - 288 2008年06月 [査読有り]
  
• Developmental modulation of the temporal relationship between brain and behavior

  Shane R. Crandall; Naoya Aoki; Teresa A. Nick

  JOURNAL OF NEUROPHYSIOLOGY 97 1 806 - 816 2007年01月 [査読有り]
  
• Localized lesions of arcopallium intermedium of the lateral forebrain caused a handling-cost aversion in the domestic chick performing a binary choice task

  Naoya Aoki; Andras Csillag; Toshiya Matsushima

  EUROPEAN JOURNAL OF NEUROSCIENCE 24 8 2314 - 2326 2006年10月 [査読有り]
  
• Localized lesions of ventral striatum, but not arcopallium, enhanced impulsiveness in choices based on anticipated spatial proximity of food rewards in domestic chicks

  N Aoki; R Suzuki; EI Izawa; A Csillag; T Matsushima

  BEHAVIOURAL BRAIN RESEARCH 168 1 1 - 12 2006年03月 [査読有り]
  
• Neural correlates of the proximity and quantity of anticipated food rewards in the ventral striatum of domestic chicks

  EI Izawa; N Aoki; T Matsushima

  EUROPEAN JOURNAL OF NEUROSCIENCE 22 6 1502 - 1512 2005年09月 [査読有り]
  
• Neural correlates of memorized associations and cued movements in archistriatum of the domestic chick

  N Aoki; EI Izawa; S Yanagihara; T Matsushima

  EUROPEAN JOURNAL OF NEUROSCIENCE 17 9 1935 - 1946 2003年05月 [査読有り]
  
• The mind through chick eyes: Memory, cognition and anticipation

  T Matsushima; EI Izawa; N Aoki; S Yanagihara

  ZOOLOGICAL SCIENCE 20 4 395 - 408 2003年04月 [査読有り]
  
• Lesions of the ventro-medial basal ganglia impair the reinforcement but not the recall of memorized color discrimination in domestic chicks

  EI Izawa; G Zachar; N Aoki; K Koga; T Matsushima

  BEHAVIOURAL BRAIN RESEARCH 136 2 405 - 414 2002年11月 [査読有り]
  

MISC

• 甲状腺ホルモンによって賦与されるニワトリヒナの早期学習能力

  本間光一; 青木直哉; 山口真二; 藤田俊之; 藤田永子 Annual Meeting of Japanese Avian Endocrinology 43rd 2019年
• 甲状腺ホルモンは課題転換での柔軟性を向上させる

  青木直哉; 藤田俊之; 藤田永子; 山口真二; 本間光一 Annual Meeting of Japanese Avian Endocrinology 43rd 2019年
• 学びの生化学 : 鳥類の学習(インプリンティング)をモデルとした"脳力"獲得の分子機構

  本間 光一; 山口 真二; 青木 直哉 生化學 85 (5) 315 -327 2013年05月
• Characterizations of chick voltage-sensing phosphatase and its possible role in regulation of cell structure

  Yasushi Okamura; Shinji Yamaguchi; Ikuko Taira; Tatsuki Kurokawa; Naoya Aoki; Souhei Sakata; Kouichi Homma NEUROSCIENCE RESEARCH 71 E230 -E230 2011年
• Impulsive choice in domestic chicks: context dependence and dissociation between delay and handling cost

  Toshiya Matsushima; Naoya Aoki; Andras Csillag NEUROSCIENCE RESEARCH 55 S94 -S94 2006年
• FUNCTIONAL ROLE OF 'ANTICIPATION' IN BASAL GANGLION OF DOMESTIC CHICKS : SUPPRESSION OF IMPULSIVENESS(Physiology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan) :

  Izawa Ei-Ichi; Aoki Naoya; Matsushima Toshiya Zoological science 19 (12) 1469 -1469 2002年
• MEMORY RELATED NEURONAL ACTIVITIES IN THE LIMBIC SYSTEM OF DOMESTIC CHICKS(Physiology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan) :

  Aoki Naoya; Izawa Ei-Ichi; Matsushima Toshiya Zoological science 19 (12) 1469 -1469 2002年

共同研究・競争的資金等の研究課題

• 鳥類刷り込みの臨界期及び記憶形成に関わる神経伝達物質の行動薬理学的・生理学的解析

  日本学術振興会：科学研究費助成事業

  研究期間 : 2020年04月 -2023年03月 

  代表者 : 青木 直哉
• 鳥類刻印付け記憶の固定化に関わる神経回路の解析

  日本学術振興会：科学研究費助成事業

  研究期間 : 2016年04月 -2018年03月 

  代表者 : 青木 直哉
• 刷り込み学習の臨界期を決定する脳内分子機構

  日本学術振興会：科学研究費助成事業

  研究期間 : 2015年04月 -2018年03月 

  代表者 : 山口 真二; 青木 直哉
• 鳥類刻印付けにおける神経栄養因子の機能解析

  日本学術振興会：科学研究費助成事業

  研究期間 : 2012年04月 -2014年03月 

  代表者 : 青木 直哉
• 鳥類の記憶形成（刻印付け）における最初期遺伝子群の機能と神経微細構造変化

  日本学術振興会：科学研究費助成事業

  研究期間 : 2011年 -2013年 

  代表者 : 本間 光一; 青木 直哉