藤島　利江 (フジシマ　トシエ)

研究者情報

所属

• 薬学部 教授
• 大学院薬学研究科 教授

学位

• 博士(薬学)（東京大学）
• 修士(薬学)（東京大学）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901029780546154

J-Global ID

• 200901029780546154

研究キーワード

• 核受容体   ビタミンD   Nuclear Receptor   Vitamin D   

研究分野

• ライフサイエンス / 生物有機化学
• ナノテク・材料 / 構造有機化学、物理有機化学

所属学協会

• 日本ビタミン学会   日本薬学会   

研究活動情報

書籍

• Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D3 Analogs

  Recent Results of Cancer Research, Antitumor Effects of Vitamin D Analogs 2003年
• Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D3 Analogs

  Recent Results of Cancer Research, Antitumor Effects of Vitamin D Analogs 2003年

作品等

• ビタミン D 誘導体の代謝研究

  2002年
• Metabolism of vitamin D analoguesr

  2002年
• ビタミン D 誘導体の受容体結合様式解析

  2000年
• Binding modes of vitamin D analogues to vitamin D receptor

  2000年

MISC

• Metabolism of 2α-Propoxy-1α,25-dihydroxyvitamin D3 and 2α-(3-Hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1

  D Abe; T Sakaki; T Kusudo; A Kittaka; N Saito; Y Suhara; T Fujishima; H Takayama; H Hamamoto; M Kamakura; M Ohta; K Inouye Drug Metabolism Disposition 33 (6) 778 -784 2005年06月
• Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D-3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D-3 by human CYP27A1 and CYP24A1

  D Abe; T Sakaki; T Kusudo; A Kittaka; N Saito; Y Suhara; T Fujishima; H Takayama; H Hamamoto; M Kamakura; M Ohta; K Inouye DRUG METABOLISM AND DISPOSITION 33 (6) 778 -784 2005年06月
• The Antagonism between 2-Methyl-1,25-dihydroxyvitamin D3 and 2-Methyl-20-epi-1,25-dihydroxyvitamin D3 in Non-genomic Pathway-mediated Biological Responses Induced by 1α,25-Dihydroxyvitamin D3 Assessed by NB4 Cell Differentiation

  D Miura; AW Norman; MT Mizwicki; T Fujishima; K Konno; A Kittaka; H Takayama; S Ishizuka J. Steroid Biochem. Mol. Biol. 94 (5) 469 -479 2005年04月
• The antagonism between 2-methyl-1,25-dihydroxyvitamin D-3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D-3 in non-genomic pathway-mediated biological responses induced by 1 alpha,25-dihydroxyvitamin D-3 assessed by NB4 cell differentiation

  D Miura; AW Norman; MT Mizwicki; T Fujishima; K Konno; A Kittaka; H Takayama; S Ishizuka JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 94 (5) 469 -479 2005年04月
• Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity

  N Saito; Y Suhara; M Kurihara; T Fujishima; S Honzawa; H Takayanagi; T Kozono; M Matsumoto; M Ohmori; N Miyata; H Takayama; A Kittaka J. Org. Chem. 69 (22) 7463 -7471 2004年10月
• Design and efficient synthesis of 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D-3 analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity

  N Saito; Y Suhara; M Kurihara; T Fujishima; S Honzawa; H Takayanagi; T Kozono; M Matsumoto; M Ohmori; N Miyata; H Takayama; A Kittaka JOURNAL OF ORGANIC CHEMISTRY 69 (22) 7463 -7471 2004年10月
• Metabolism of A-ring Diastereomers of 1α,25-Dihydroxyvitamin D3 by CYP24A1

  T Kusudo; T Sakaki; D Abe; T Fujishima; A Kittaka; H Takayama; S Hatakeyama; M Ohta; K Inouye Biochem. Biophys. Res. Commun. 321 (4) 774 -782 2004年09月
• 2,2-Functionalized analogues of 1 alpha,25-dihydroxyvitamin D-3, the potent inducers of cell differentiation

  T Fujishima; A Kittaka; M Kurihara; N Saito; S Honzawa; S Kishimoto; T Sugiura; K Waku; H Takayama JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 89-90 (1-5) 89 -92 2004年05月
• Synthesis of Novel 1α,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate

  Heterocycles 62, 423-436 2004年
• 2,2-Functionalized Analogues of 1α,25-dihydroxyvitamin D3: The Potent Inducers of Cell Differentiation

  J. Steroid Biochem. Mol. Biol. 89-90, 89-92. 2004年
• Metabolism of A-ring Diastereomers of 1α,25-Dihydroxyvitamin D3 by CYP24A1

  Biochem. Biophys. Res. Commun. 321, 774-782. 2004年
• Synthesis of Novel 1α,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate

  Heterocycles 62, 423-436 2004年
• Dramatic Enhancement of Antagonistic Activity on Vitamin D Receptor: A Double Functionalization of 1α-Hydroxyvitamin D3 26,23-Lactones

  N Saito; H Saito; M Anzai; A Yoshida; T Fujishima; K Takenouchi; D Miura; S Ishizuka; H Takayama; A Kittaka Org. Lett. 5 (25) 4859 -4862 2003年12月
• Dramatic enhancement of antagonistic activity on vitamin D receptor: A double functionalization of 1 alpha-hydroxyvitamin D-3 26,23-lactones

  N Saito; H Saito; M Anzai; A Yoshida; T Fujishima; K Takenouchi; D Miura; S Ishizuka; H Takayama; A Kittaka ORGANIC LETTERS 5 (25) 4859 -4862 2003年12月
• Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: Remarkable effects of 2 alpha-methyl introduction on antagonistic activity

  T Fujishima; Y Kojima; Azumaya, I; A Kittaka; H Takayama BIOORGANIC & MEDICINAL CHEMISTRY 11 (17) 3621 -3631 2003年08月
• Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D-3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

  T Fujishima; A Kittaka; K Yamaoka; K Takeyama; S Kato; H Takayama ORGANIC & BIOMOLECULAR CHEMISTRY 1 (11) 1863 -1869 2003年05月
• Remarkable Effect of 2α-Modification on the VDR Antagonistic Activity of 1α-Hydroxyvitamin D3-26,23-lactones

  N Saito; T Matsunaga; T Fujishima; M Anzai; H Saito; K Takenouchi; D Miura; S Ishizuka; H Takayama; A Kittaka Org. Biomol. Chem. 1 (24) 4396 -4402 2003年
• Design and Synthesis of Potent Vitamin D Antagonists with A-Ring Modifications: Remarkable Effects of 2α-Methyl Introduction on Antagonistic Activity

  Bioorg. Med. Chem. 11, 3621-3631 2003年
• Synthesis of 2,2-Dimethyl-1,25-dihydroxyvitamin D3: A-Ring Structural Motif that Modulates Interactions of Vitamin D Receptor with Transcriptional Coactivators

  Org. Biomol. Chem. 1, 1863-1869 2003年
• Remarkable effect of 2 alpha-modification on the VDR antagonistic activity of 1 alpha-hydroxyvitamin D(3)-26,23-lactones

  N Saito; T Matsunaga; T Fujishima; M Anzai; H Saito; K Takenouchi; D Miura; S Ishizuka; H Takayama; A Kittaka ORGANIC & BIOMOLECULAR CHEMISTRY 1 (24) 4396 -4402 2003年
• Synthesis and testing of 2α-Modified 1α, 25-dihydroxyvitamin D3 analogues with a Double Side Chain : Marked cell differentiation activity

  SUHARA Y; KITTAKA A; KISHIMOTO S; CALVERLEY M J; FUJISHIMA T; SAITO N; SUGIURA T; WAKU K; TAKAYAMA H Bioorg, Med, Chem, Lett 12 (22) 3255 -3258 2002年11月
• Synthesis and testing of 2α-Modified 1α, 25-dihydroxyvitamin D3 analogues with a Double Side Chain : Marked cell differentiation activity

  SUHARA Y; KITTAKA A; KISHIMOTO S; CALVERLEY M J; FUJISHIMA T; SAITO N; SUGIURA T; WAKU K; TAKAYAMA H Bioorg, Med, Chem, Lett 12 (22) 3255 -3258 2002年11月
• Synthesis and testing of 2 alpha-modified 1 alpha,25-dihydroxyvitamin D-3 analogues with a double side chain: Marked cell differentiation activity

  Y Suhara; A Kittaka; S Kishimoto; MJ Calverley; T Fujishima; N Saito; T Sugiura; K Waku; H Takayama BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12 (22) 3255 -3258 2002年11月
• Metabolism of 2-methyl Analogs of 1α, 25-dihydroxyvitain D3 in Rat osteosarcoma cells

  Bioorg, Med, Chem, Lett 25 (7) 845 -852 2002年
• Design and efficient synthesis of New stable 1α, 25-dihydroxy-19-norvitamin D3 analogues containing amide bond

  SUHARA Y; KITTAKA A; ONO K; KURIHARA M; FUJISHIMA T; YOSHIDA A; TAKAYAMA H Bioorg, Med, Chem, Lett 12 (24) 3533 -3536 2002年
• Metabolism of 2-methyl Analogs of 1α, 25-dihydroxyvitain D3 in Rat osteosarcoma cells

  Bioorg, Med, Chem, Lett 25 (7) 845 -852 2002年
• Design and efficient synthesis of New stable 1α, 25-dihydroxy-19-norvitamin D3 analogues containing amide bond

  SUHARA Y; KITTAKA A; ONO K; KURIHARA M; FUJISHIMA T; YOSHIDA A; TAKAYAMA H Bioorg, Med, Chem, Lett 12 (24) 3533 -3536 2002年
• 十字路：細胞分化誘導作用

  有機合成化学協会誌 (60) 389 2002年
• A環修飾活性型ビタミンD3の合成と活性

  高山浩明; 橘高敦史; 藤島利江; 須原義智 有機合成化学協会誌 60 (4) 370 -382 2002年
• 活性型ビタミンD3のA環修飾、特に2位の官能基化と生物活性

  ビタミン (76) 3491 -3505 2002年
• Determination of Absolute Configuration of 1,3-diols by the modified Mosher's method using their di-MTPA seters.

  Chirality 14 (1) 72 2002年
• Metabolism of 2-methyl Analogs of 1α, 25-dihydroxyvitain D3 in Rat osteosarcoma cells

  Devara Sunita Rao; Mei-Ling Siu-Caldera; Hiroko Sekimoto; Lynn Gennaro; Paul Vouros; Hiroaki Takayama; Katsuhiro Konno; Toshie Fujishima; Gudimetla Satyanarayana Reddy Bioorg, Med, Chem, Lett 25 (7) 845 -852 2002年
• Design and efficient synthesis of New stable 1α, 25-dihydroxy-19-norvitamin D3 analogues containing amide bond

  Bioorg, Med, Chem, Lett 12 (24) 3533 -3536 2002年
• Determination of Absolute Configuration of 1,3-diols by the modified Mosher's method using their di-MTPA seters.

  Chirality 14 (1) 72 2002年
• Efficient and Versatile Synthesis of Novel 2α-Substituted 1α, 25-dihydroxyvitamin D₃ Analogues and their Docking to Vitamin D Receptor.

  SUHARA Y; NIHEI K; KURIHARA M; KITTAKA A; YAMAGUCHI K; FUJISHIMA T; KONNO K; MIYATA N; TAKAYAMA H J. Org. Chem 66 (26) 8760 -8771 2001年12月
• Efficient and Versatile Synthesis of Novel 2α-Substituted 1α, 25-dihydroxyvitamin D3 Analogues and their Docking to Vitamin D Receptor.

  SUHARA Y; NIHEI K; KURIHARA M; KITTAKA A; YAMAGUCHI K; FUJISHIMA T; KONNO K; MIYATA N; TAKAYAMA H J. Org. Chem 66 (26) 8760 -8771 2001年12月
• Efficient and versatile synthesis of novel 2 alpha-substituted 1 alpha,25-dihydroxyvitamin D-3 analogues and their docking to vitamin D receptors

  Y Suhara; K Nihei; M Kurihara; A Kittaka; K Yamaguchi; T Fujishima; K Konno; N Miyata; H Takayama JOURNAL OF ORGANIC CHEMISTRY 66 (26) 8760 -8771 2001年12月
• Synthesis and Biological Evaluation of All possible A-ring Stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D3 and their 20-epiners

  Chemistry & Biology 8 (11) 1011 2001年
• Synthesis and Biological Evaluation of All possible A-ring Stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D₃ and their 20-epiners

  Chemistry & Biology 8 (11) 1011 2001年
• Structure-specific control of differentiation and apoptosis of human promyelocytic leukemia (HL-60) cells by a ring diastereomers of 2-methyl-1 alpha,25-dihydroxyvitamin D-3 and its 20-epimer

  K Nakagawa; M Kurobe; K Konno; T Fujishima; H Takayama; T Okano BIOCHEMICAL PHARMACOLOGY 60 (12) 1937 -1947 2000年12月
• Synthesis, biological evaluation, and conformational analysis of A-ring diastereomers of 2-methyl-1,25-dihydroxyvitamin D-3 and their 20-epimers: Unique activity profiles depending on the stereochemistry of the A-ring and at C-20

  K Konno; T Fujishima; S Maki; ZP Liu; D Miura; M Chokki; S Ishizuka; K Yamaguchi; Y Kan; M Kurihara; N Miyata; C Smith; HF DeLuca; H Takayama JOURNAL OF MEDICINAL CHEMISTRY 43 (22) 4247 -4265 2000年11月
• A concise and efficient route to 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D-3: Remarkably high affinity to vitamin D receptor

  A Kittaka; Y Suhara; H Takayanagi; T Fujishima; M Kurihara; H Takayama ORGANIC LETTERS 2 (17) 2619 -2622 2000年08月
• Syntheses and biological evaluation of novel 2 alpha-substituted 1 alpha,25-dihydroxyvitamin D-3 analogues

  Y Suhara; K Nihei; H Tanigawa; T Fujishima; K Konno; K Nakagawa; T Okano; H Takayama BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10 (10) 1129 -1132 2000年05月
• Novel ring A stereoisomers of 2-methyl-1 alpha,25-dihydroxyvitamin D-3 and 2-methyl-20-epi-1 alpha,25-dihydroxyvitamin D-3: Transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells

  K Nakagawa; M Kurobe; K Ozono; K Konno; T Fujishima; H Takayama; T Okano BIOCHEMICAL PHARMACOLOGY 59 (6) 691 -702 2000年03月
• Efficient synthesis and biological evaluation of all A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D-3 and its 20-epimer

  T Fujishima; K Konno; K Nakagawa; M Kurobe; T Okano; H Takayama BIOORGANIC & MEDICINAL CHEMISTRY 8 (1) 123 -134 2000年01月
• Establishment of permanent cell lines exhibiting vitamin D-dependent expression of beta-galactosidase activity

  Y Negishi; N Kajiyama; K Kawashima; T Fujishima; H Takayama; H Endo; R Kawaguchi BIOCHEMICAL PHARMACOLOGY 58 (3) 465 -470 1999年08月
• Synthesis and biological activity of 2-methyl-20-EPI analogues of 1 alpha,25-dihydroxyvitamin D-3

  T Fujishima; ZP Liu; D Miura; M Chokki; S Ishizuka; K Konno; H Takayama BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 8 (16) 2145 -2148 1998年08月
• 活性型ビタミンD₃の2-メチル-20-エピアナログの合成と生理活性

  8 (16) 2145 1998年
• 活性型ビタミンD₃及びアナログのA環前駆体合成法:A環ジアステレオマー及び2-メチルアナログ合成への応用

  8 (2) 151 1998年
• A Novel and Practical Route to A-ring enyne synthon for 1α, 25-dihydroxyvitamin D₃ Analogs : Synthesis of A-ring Diastereomers of 1α, 25-dihydroxyvitamins D₃ and 2-methyl-1,25-digydroxyvitamin D₃

  Bioorganic and Medicinal Chemistry Letters 8 (2) 151 -159 1998年
• ビタミンE誘導体の合成

  329 (1) 27 -34 1996年
• Synthesis of Vitamin E analogues : possible active forms of vitamin Em

  Archiv der Pharmazie 329 (1) 27 -34 1996年

共同研究・競争的資金等の研究課題

• ビタミンD誘導体の合成研究
• Synthesis of vitamin D analogues