Fujishima Toshie

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Professor
Graduate School of Pharmaceutical Sciences Professor

Degree

• Doctor of Philosophy（The University of Tokyo）
• Master（The University of Tokyo）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901029780546154

J-Global ID

• 200901029780546154

Research Interests

• 核受容体   ビタミンD   Nuclear Receptor   Vitamin D   

Research Areas

• Life sciences / Bioorganic chemistry
• Nanotechnology/Materials / Structural/physical organic chemistry

Association Memberships

• 日本ビタミン学会   日本薬学会   

Research Activity Information

Books etc

• Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D3 Analogs

  Recent Results of Cancer Research, Antitumor Effects of Vitamin D Analogs 2003
• Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D3 Analogs

  Recent Results of Cancer Research, Antitumor Effects of Vitamin D Analogs 2003

Works

• ビタミン D 誘導体の代謝研究

  2002
• Metabolism of vitamin D analoguesr

  2002
• ビタミン D 誘導体の受容体結合様式解析

  2000
• Binding modes of vitamin D analogues to vitamin D receptor

  2000

MISC

• Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D-3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D-3 by human CYP27A1 and CYP24A1

  D Abe; T Sakaki; T Kusudo; A Kittaka; N Saito; Y Suhara; T Fujishima; H Takayama; H Hamamoto; M Kamakura; M Ohta; K Inouye  DRUG METABOLISM AND DISPOSITION  33-  (6)  778  -784  2005/06
• Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D-3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D-3 by human CYP27A1 and CYP24A1

  D Abe; T Sakaki; T Kusudo; A Kittaka; N Saito; Y Suhara; T Fujishima; H Takayama; H Hamamoto; M Kamakura; M Ohta; K Inouye  DRUG METABOLISM AND DISPOSITION  33-  (6)  778  -784  2005/06
• The antagonism between 2-methyl-1,25-dihydroxyvitamin D-3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D-3 in non-genomic pathway-mediated biological responses induced by 1 alpha,25-dihydroxyvitamin D-3 assessed by NB4 cell differentiation

  D Miura; AW Norman; MT Mizwicki; T Fujishima; K Konno; A Kittaka; H Takayama; S Ishizuka  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY  94-  (5)  469  -479  2005/04
• The antagonism between 2-methyl-1,25-dihydroxyvitamin D-3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D-3 in non-genomic pathway-mediated biological responses induced by 1 alpha,25-dihydroxyvitamin D-3 assessed by NB4 cell differentiation

  D Miura; AW Norman; MT Mizwicki; T Fujishima; K Konno; A Kittaka; H Takayama; S Ishizuka  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY  94-  (5)  469  -479  2005/04
• Design and efficient synthesis of 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D-3 analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity

  N Saito; Y Suhara; M Kurihara; T Fujishima; S Honzawa; H Takayanagi; T Kozono; M Matsumoto; M Ohmori; N Miyata; H Takayama; A Kittaka  JOURNAL OF ORGANIC CHEMISTRY  69-  (22)  7463  -7471  2004/10
• Design and efficient synthesis of 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D-3 analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity

  N Saito; Y Suhara; M Kurihara; T Fujishima; S Honzawa; H Takayanagi; T Kozono; M Matsumoto; M Ohmori; N Miyata; H Takayama; A Kittaka  JOURNAL OF ORGANIC CHEMISTRY  69-  (22)  7463  -7471  2004/10
• Metabolism of A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D-3 by CYP24A1

  T Kusudo; T Sakaki; D Abe; T Fujishima; A Kittaka; H Takayama; S Hatakeyama; M Ohta; K Inouye  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  321-  (4)  774  -782  2004/09
• 2,2-Functionalized analogues of 1 alpha,25-dihydroxyvitamin D-3, the potent inducers of cell differentiation

  T Fujishima; A Kittaka; M Kurihara; N Saito; S Honzawa; S Kishimoto; T Sugiura; K Waku; H Takayama  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY  89-90-  (1-5)  89  -92  2004/05
• Synthesis of Novel 1α,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate

  Heterocycles  62, 423-436-  2004
• 2,2-Functionalized Analogues of 1α,25-dihydroxyvitamin D3: The Potent Inducers of Cell Differentiation

  J. Steroid Biochem. Mol. Biol.  89-90, 89-92.-  2004
• Metabolism of A-ring Diastereomers of 1α,25-Dihydroxyvitamin D3 by CYP24A1

  Biochem. Biophys. Res. Commun.  321, 774-782.-  2004
• Synthesis of Novel 1α,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate

  Heterocycles  62, 423-436-  2004
• Dramatic enhancement of antagonistic activity on vitamin D receptor: A double functionalization of 1 alpha-hydroxyvitamin D-3 26,23-lactones

  N Saito; H Saito; M Anzai; A Yoshida; T Fujishima; K Takenouchi; D Miura; S Ishizuka; H Takayama; A Kittaka  ORGANIC LETTERS  5-  (25)  4859  -4862  2003/12
• Dramatic enhancement of antagonistic activity on vitamin D receptor: A double functionalization of 1 alpha-hydroxyvitamin D-3 26,23-lactones

  N Saito; H Saito; M Anzai; A Yoshida; T Fujishima; K Takenouchi; D Miura; S Ishizuka; H Takayama; A Kittaka  ORGANIC LETTERS  5-  (25)  4859  -4862  2003/12
• Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: Remarkable effects of 2 alpha-methyl introduction on antagonistic activity

  T Fujishima; Y Kojima; Azumaya, I; A Kittaka; H Takayama  BIOORGANIC & MEDICINAL CHEMISTRY  11-  (17)  3621  -3631  2003/08
• Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D-3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

  T Fujishima; A Kittaka; K Yamaoka; K Takeyama; S Kato; H Takayama  ORGANIC & BIOMOLECULAR CHEMISTRY  1-  (11)  1863  -1869  2003/05
• Remarkable effect of 2 alpha-modification on the VDR antagonistic activity of 1 alpha-hydroxyvitamin D(3)-26,23-lactones

  N Saito; T Matsunaga; T Fujishima; M Anzai; H Saito; K Takenouchi; D Miura; S Ishizuka; H Takayama; A Kittaka  ORGANIC & BIOMOLECULAR CHEMISTRY  1-  (24)  4396  -4402  2003
• Design and Synthesis of Potent Vitamin D Antagonists with A-Ring Modifications: Remarkable Effects of 2α-Methyl Introduction on Antagonistic Activity

  Bioorg. Med. Chem.  11, 3621-3631-  2003
• Synthesis of 2,2-Dimethyl-1,25-dihydroxyvitamin D3: A-Ring Structural Motif that Modulates Interactions of Vitamin D Receptor with Transcriptional Coactivators

  Org. Biomol. Chem.  1, 1863-1869-  2003
• Remarkable effect of 2 alpha-modification on the VDR antagonistic activity of 1 alpha-hydroxyvitamin D(3)-26,23-lactones

  N Saito; T Matsunaga; T Fujishima; M Anzai; H Saito; K Takenouchi; D Miura; S Ishizuka; H Takayama; A Kittaka  ORGANIC & BIOMOLECULAR CHEMISTRY  1-  (24)  4396  -4402  2003
• Synthesis and testing of 2 alpha-modified 1 alpha,25-dihydroxyvitamin D-3 analogues with a double side chain: Marked cell differentiation activity

  Y Suhara; A Kittaka; S Kishimoto; MJ Calverley; T Fujishima; N Saito; T Sugiura; K Waku; H Takayama  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  12-  (22)  3255  -3258  2002/11
• Synthesis and testing of 2 alpha-modified 1 alpha,25-dihydroxyvitamin D-3 analogues with a double side chain: Marked cell differentiation activity

  Y Suhara; A Kittaka; S Kishimoto; MJ Calverley; T Fujishima; N Saito; T Sugiura; K Waku; H Takayama  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  12-  (22)  3255  -3258  2002/11
• Synthesis and testing of 2 alpha-modified 1 alpha,25-dihydroxyvitamin D-3 analogues with a double side chain: Marked cell differentiation activity

  Y Suhara; A Kittaka; S Kishimoto; MJ Calverley; T Fujishima; N Saito; T Sugiura; K Waku; H Takayama  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  12-  (22)  3255  -3258  2002/11
• Metabolism of 2-methyl Analogs of 1α, 25-dihydroxyvitain D3 in Rat osteosarcoma cells

  Bioorg, Med, Chem, Lett  25-  (7)  845  -852  2002
• Design and efficient synthesis of New stable 1α, 25-dihydroxy-19-norvitamin D3 analogues containing amide bond

  SUHARA Y; KITTAKA A; ONO K; KURIHARA M; FUJISHIMA T; YOSHIDA A; TAKAYAMA H  Bioorg, Med, Chem, Lett  12-  (24)  3533  -3536  2002
• Metabolism of 2-methyl Analogs of 1α, 25-dihydroxyvitain D3 in Rat osteosarcoma cells

  Bioorg, Med, Chem, Lett  25-  (7)  845  -852  2002
• Design and efficient synthesis of New stable 1α, 25-dihydroxy-19-norvitamin D3 analogues containing amide bond

  SUHARA Y; KITTAKA A; ONO K; KURIHARA M; FUJISHIMA T; YOSHIDA A; TAKAYAMA H  Bioorg, Med, Chem, Lett  12-  (24)  3533  -3536  2002
• 十字路：細胞分化誘導作用

  有機合成化学協会誌  (60)  389  2002
• A環修飾活性型ビタミンD3の合成と活性

  高山浩明; 橘高敦史; 藤島利江; 須原義智  有機合成化学協会誌  60-  (4)  370  -382  2002
• 活性型ビタミンD3のA環修飾、特に2位の官能基化と生物活性

  ビタミン  (76)  3491  -3505  2002
• Determination of Absolute Configuration of 1,3-diols by the modified Mosher's method using their di-MTPA seters.

  Chirality  14-  (1)  72  2002
• Metabolism of 2-methyl Analogs of 1α, 25-dihydroxyvitain D3 in Rat osteosarcoma cells

  Devara Sunita Rao; Mei-Ling Siu-Caldera; Hiroko Sekimoto; Lynn Gennaro; Paul Vouros; Hiroaki Takayama; Katsuhiro Konno; Toshie Fujishima; Gudimetla Satyanarayana Reddy  Bioorg, Med, Chem, Lett  25-  (7)  845  -852  2002
• Design and efficient synthesis of New stable 1α, 25-dihydroxy-19-norvitamin D3 analogues containing amide bond

  Bioorg, Med, Chem, Lett  12-  (24)  3533  -3536  2002
• Determination of Absolute Configuration of 1,3-diols by the modified Mosher's method using their di-MTPA seters.

  Chirality  14-  (1)  72  2002
• Efficient and versatile synthesis of novel 2 alpha-substituted 1 alpha,25-dihydroxyvitamin D-3 analogues and their docking to vitamin D receptors

  Y Suhara; K Nihei; M Kurihara; A Kittaka; K Yamaguchi; T Fujishima; K Konno; N Miyata; H Takayama  JOURNAL OF ORGANIC CHEMISTRY  66-  (26)  8760  -8771  2001/12
• Efficient and versatile synthesis of novel 2 alpha-substituted 1 alpha,25-dihydroxyvitamin D-3 analogues and their docking to vitamin D receptors

  Y Suhara; K Nihei; M Kurihara; A Kittaka; K Yamaguchi; T Fujishima; K Konno; N Miyata; H Takayama  JOURNAL OF ORGANIC CHEMISTRY  66-  (26)  8760  -8771  2001/12
• Efficient and versatile synthesis of novel 2 alpha-substituted 1 alpha,25-dihydroxyvitamin D-3 analogues and their docking to vitamin D receptors

  Y Suhara; K Nihei; M Kurihara; A Kittaka; K Yamaguchi; T Fujishima; K Konno; N Miyata; H Takayama  JOURNAL OF ORGANIC CHEMISTRY  66-  (26)  8760  -8771  2001/12
• Synthesis and Biological Evaluation of All possible A-ring Stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D3 and their 20-epiners

  Chemistry & Biology  8-  (11)  1011  2001
• Synthesis and Biological Evaluation of All possible A-ring Stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D₃ and their 20-epiners

  Chemistry & Biology  8-  (11)  1011  2001
• Structure-specific control of differentiation and apoptosis of human promyelocytic leukemia (HL-60) cells by a ring diastereomers of 2-methyl-1 alpha,25-dihydroxyvitamin D-3 and its 20-epimer

  K Nakagawa; M Kurobe; K Konno; T Fujishima; H Takayama; T Okano  BIOCHEMICAL PHARMACOLOGY  60-  (12)  1937  -1947  2000/12
• Synthesis, biological evaluation, and conformational analysis of A-ring diastereomers of 2-methyl-1,25-dihydroxyvitamin D-3 and their 20-epimers: Unique activity profiles depending on the stereochemistry of the A-ring and at C-20

  K Konno; T Fujishima; S Maki; ZP Liu; D Miura; M Chokki; S Ishizuka; K Yamaguchi; Y Kan; M Kurihara; N Miyata; C Smith; HF DeLuca; H Takayama  JOURNAL OF MEDICINAL CHEMISTRY  43-  (22)  4247  -4265  2000/11
• A concise and efficient route to 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D-3: Remarkably high affinity to vitamin D receptor

  A Kittaka; Y Suhara; H Takayanagi; T Fujishima; M Kurihara; H Takayama  ORGANIC LETTERS  2-  (17)  2619  -2622  2000/08
• Syntheses and biological evaluation of novel 2 alpha-substituted 1 alpha,25-dihydroxyvitamin D-3 analogues

  Y Suhara; K Nihei; H Tanigawa; T Fujishima; K Konno; K Nakagawa; T Okano; H Takayama  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  10-  (10)  1129  -1132  2000/05
• Novel ring A stereoisomers of 2-methyl-1 alpha,25-dihydroxyvitamin D-3 and 2-methyl-20-epi-1 alpha,25-dihydroxyvitamin D-3: Transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells

  K Nakagawa; M Kurobe; K Ozono; K Konno; T Fujishima; H Takayama; T Okano  BIOCHEMICAL PHARMACOLOGY  59-  (6)  691  -702  2000/03
• Efficient synthesis and biological evaluation of all A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D-3 and its 20-epimer

  T Fujishima; K Konno; K Nakagawa; M Kurobe; T Okano; H Takayama  BIOORGANIC & MEDICINAL CHEMISTRY  8-  (1)  123  -134  2000/01
• Establishment of permanent cell lines exhibiting vitamin D-dependent expression of beta-galactosidase activity

  Y Negishi; N Kajiyama; K Kawashima; T Fujishima; H Takayama; H Endo; R Kawaguchi  BIOCHEMICAL PHARMACOLOGY  58-  (3)  465  -470  1999/08
• Synthesis and biological activity of 2-methyl-20-EPI analogues of 1 alpha,25-dihydroxyvitamin D-3

  T Fujishima; ZP Liu; D Miura; M Chokki; S Ishizuka; K Konno; H Takayama  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  8-  (16)  2145  -2148  1998/08
• 活性型ビタミンD₃の2-メチル-20-エピアナログの合成と生理活性

  8-  (16)  2145  1998
• 活性型ビタミンD₃及びアナログのA環前駆体合成法:A環ジアステレオマー及び2-メチルアナログ合成への応用

  8-  (2)  151  1998
• A Novel and Practical Route to A-ring enyne synthon for 1α, 25-dihydroxyvitamin D₃ Analogs : Synthesis of A-ring Diastereomers of 1α, 25-dihydroxyvitamins D₃ and 2-methyl-1,25-digydroxyvitamin D₃

  Bioorganic and Medicinal Chemistry Letters  8-  (2)  151  -159  1998
• ビタミンE誘導体の合成

  329-  (1)  27  -34  1996
• Synthesis of Vitamin E analogues : possible active forms of vitamin Em

  Archiv der Pharmazie  329-  (1)  27  -34  1996

Research Grants & Projects

• ビタミンD誘導体の合成研究
• Synthesis of vitamin D analogues