根岸　文子 (ネギシ　フミコ)

研究者情報

所属

• 薬学部 准教授

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201401083584807114

J-Global ID

• 201401083584807114

研究キーワード

• アディポサイトカイン   炎症   肥満   脂肪細胞分化   シアリダーゼ   PU.1   分化   転写因子   白血病   赤白血病   赤白血球   転写調節   血液細胞分化   リン酸化   アセチル化   胚性腫瘍細胞   アポトーシス   細胞分化   細胞増殖   マウス赤白血病(MEL)   Ets   血球分化   がん遺伝子   HDAC   分化のスイッチ   骨髄球   T細胞   SV40   Etsファミリー転写因子   機能的相互作用   lck   Defferential Display法   CKLiK   複製   Diffrential Display法   

研究分野

• ライフサイエンス / 血液、腫瘍内科学
• ライフサイエンス / 実験病理学
• ライフサイエンス / 発生生物学

経歴

• 2012年04月  帝京大学薬学部・基礎生物学准教授

研究活動情報

論文

• Effects of fermented rice vinegar Kurozu and its sediment on inflammation-induced plasminogen activator 1 (PAI-1) increase.

  N. Ohkura N; Kihara-Negishi F. Fujii A; Kanouchi H; Oishi K; Atsumi G; Nagano M

  Food and Nutrition Sciences 9 3 235 - 246 2018年 [査読有り]
  
• NEU1 sialidase controls gene expression and secretion of IL-6 and MCP-1 through NF-κB pathway in 3T3-L1 adipocytes.

  Natori Y; Nasui M; Edo K; Sato S; Sakurai T; Kizaki T; Kihara-Negishi F

  Journal of biochemistry 162 2 137 - 143 2017年08月 [査読有り]
  
• Neu1 sialidase interacts with perilipin 1 on lipid droplets and inhibits lipolysis in 3T3-L1 adipocytes

  Yujin Natori; Miwako Nasui; Fumiko Kihara-Negishi

  GENES TO CELLS 22 5 485 - 492 2017年05月 [査読有り]
  
• Simultaneous determination of catechins and caffeine in green tea-based beverages and foods for specified health uses.

  K. Maruyama; F. Kihara-Negishi; N. Okura; Y. Nakamura; M. Nasui; M. Saito

  . 8 3 316 - 325 2017年 [査読有り]
  
• Effects of a diet containing Brazilian propolis on lipopolysaccharideinduced increases in plasma plasminogen activator inhibitor-1 levels in mice

  Naoki Ohkura; Katsutaka Oishi; Fumiko Kihara-Negishi; Gen-Ichi Atsumi; Tomoki Tatefuji

  Journal of Intercultural Ethnopharmacology 5 4 439 - 443 2016年 [査読有り]
  
• Comparison of Quality and Stability of limaprost-alfadex Generics against Branded Products.

  Fumiko Negishi

  Jan. J. Pharm. Health Care Sci. 36 143 - 149 2010年 [査読有り]
  
• Quantification of the Levels of CYP2D6 mRNA in Peripheral Blood Leukocytes by Reverse Transcriptase Polymerase Chain Reaction HPLC

  Satoko Nagano; Hiroyuki Hosono; Fumiko Negishi; Mashiho Yanagi; Masato Homma; Yukinao Kohda; Machiko Watanabe

  CHEMICAL & PHARMACEUTICAL BULLETIN 57 11 1278 - 1281 2009年11月 [査読有り]
  
• Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins

  Toshiyuki Yamada; Takeshi Shimizu; Takuya Sakurai; Naoki Nanashima; Fumiko Kihara-Negishi; Mitsuhiro Suzuki; Yang Fan; Miki Akita; Tsuneyuki Oikawa; Shigeki Tsuchida

  LEUKEMIA RESEARCH 33 3 483 - 489 2009年03月 [査読有り]
  
• Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells

  Toshiyuki Yamada; Takeshi Shimizu; Mitsuhiro Suzuki; Fumiko Kihara-Negishi; Naoki Nanashima; Takuya Sakurai; Yang Fan; Miki Akita; Tsuneyuki Oikawa; Shigeki Tsuchida

  EXPERIMENTAL CELL RESEARCH 314 4 847 - 858 2008年02月 [査読有り]
  
• Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy

  Takuya Sakurai; Nobuo Kondoh; Masaaki Arai; Jun-Ichi Hamada; Toshiyuki Yamada; Fumiko Kihara-Negishi; Tetsuya Izawa; Hideki Ohno; Mikio Yamamoto; Tsuneyuki Oikawa

  CANCER SCIENCE 98 11 1775 - 1784 2007年11月 [査読有り]
  
• Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression

  Y. Nakazawa; M. Suzuki; N. Manabe; T. Yamada; F. Kihara-Negishi; T. Sakurai; D. G. Tenen; A. Iwama; M. Mochizuki; T. Oikawa

  ONCOGENE 26 24 3541 - 3550 2007年05月 [査読有り]
  
• Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b

  M Suzuki; T Yamada; F Kihara-Negishi; T Sakurai; E Hara; DG Tenen; N Hozumi; T Oikawa

  ONCOGENE 25 17 2477 - 2488 2006年04月 [査読有り]
  
• Classification of neural differentiation-associated genes in P19 embryonal carcinoma cells by their expression patterns induced after cell aggregation and/or retinoic acid treatment

  S Teramoto; F Kihara-Negishi; T Sakurai; T Yamada; T Hashimoto-Tamaoki; S Tamura; S Kohno; T Oikawa

  ONCOLOGY REPORTS 14 5 1231 - 1238 2005年11月 [査読有り]
  
• Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain

  F Kihara-Negishi; M Suzuki; T Yamada; T Sakurai; T Oikawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 335 2 477 - 484 2005年09月 [査読有り]
  
• Oikawa T, Yamada T, Kihara-Negishi F, Sakurai T. Ets family of transcriotion factors in normal hematopoiesis and in leukemogenesis.

  Oikawa T; Yamada T; Kihara-Negishi F; Sakurai T

  25 119 - 148 2005年 [査読有り]
  
• Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells

  T Yamada; M Suzuki; H Satoh; F Kihara-Negishi; H Nakano; T Oikawa

  EXPERIMENTAL CELL RESEARCH 294 1 39 - 50 2004年03月 [査読有り]
  
• Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression

  M Suzuki; T Yamada; F Kihara-Negishi; T Sakurai; T Oikawa

  ONCOGENE 22 54 8688 - 8698 2003年11月 [査読有り]
  
• Effects of overexpression of the Ets family transcription factor TEL on cell growth and differentiation of K562 cells

  T Sakurai; T Yamada; F Kihara-Negishi; S Teramoto; Y Sato; T Izawa; T Oikawa

  INTERNATIONAL JOURNAL OF ONCOLOGY 22 6 1327 - 1333 2003年06月 [査読有り]
  
• Prevention of PU.1-induced growth inhibition and apoptosis but not differentiation block in murine erythroleukemia cells by overexpression of CBP

  N Manabe; H Yamamoto; T Yamada; F Kihara-Negishi; Y Hashimoto; M Mochizuki; T Oikawa

  INTERNATIONAL JOURNAL OF ONCOLOGY 22 6 1345 - 1350 2003年06月 [査読有り]
  
• Effects of overexpression of the Ets family transcription factor TEL on cell growth and differentiation of K562.

  Sakurai T; Yamada T; Kihara-Negishi F; Teramoto S; Sato Y; Izawa T; Oikawa T

  Int J Oncology. 22 1327 - 1333 2003年 [査読有り]
  
• Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb.

  Yamamoto H; Kihara-Negishi F; Yamada T; Suzuki M; Nakano T; Oikawa T

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 13 69 - 75 2 2002年02月 [査読有り]
  
• Extinction of expression of the genes encoding haematopoietic cell-restricted transcription factors in T-lymphoma x fibroblast cell hybrids

  T Oikawa; T Yamada; N Kondoh; F Negishi-Kihara; Y Hitomi; M Suzuki; S Teramoto

  IMMUNOLOGY 104 2 162 - 167 2001年10月 [査読有り]
  
• In vivo complex formation of PU.1 with HDAC1 associated with PU.1-mediated transcriptional repression

  F Kihara-Negishi; H Yamamoto; M Suzuki; T Yamada; T Sakurai; T Tamura; T Oikawa

  ONCOGENE 20 42 6039 - 6047 2001年09月 [査読有り]
  
• Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells

  T Yamada; M Abe; T Higashi; H Yamamoto; F Kihara-Negishi; T Sakurai; T Shirai; T Oikawa

  BLOOD 97 8 2300 - 2307 2001年04月 [査読有り]
  
• The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis

  T Oikawa; T Yamada; F Kihara-Negishi; H Yamamoto; N Kondoh; Y Hitomi; Y Hashimoto

  CELL DEATH AND DIFFERENTIATION 6 7 599 - 608 1999年07月 [査読有り]
  
• Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP

  H Yamamoto; F Kihara-Negishi; T Yamada; Y Hashimoto; T Oikawa

  ONCOGENE 18 7 1495 - 1501 1999年02月 [査読有り]
  
• Reduction of DNA binding activity of the GATA-1 transcription factor in the apoptotic process induced by overexpression of PU.1 in murine erythroleukemia cells

  T Yamada; F Kihara-Negishi; H Yamamoto; M Yamamoto; Y Hashimoto; T Oikawa

  EXPERIMENTAL CELL RESEARCH 245 1 186 - 194 1998年11月 [査読有り]
  
• Enhanced expression of the urokinase-type plasminogen activator gene and reduced colony formation in soft agar by ectopic expression of PU.1 in HT1080 human fibrosarcoma cells

  N Kondoh; T Yamada; F Kihara-Negishi; M Yamamoto; T Oikawa

  BRITISH JOURNAL OF CANCER 78 6 718 - 723 1998年09月 [査読有り]
  
• Down-regulation of c-myc and bcl-2 gene expression in PU.1-induced apoptosis in murine erythroleukemia cells

  F Kihara-Negishi; T Yamada; Y Kubota; N Kondoh; H Yamamoto; M Abe; T Shirai; Y Hashimoto; T Oikawa

  INTERNATIONAL JOURNAL OF CANCER 76 4 523 - 530 1998年05月 [査読有り]
  
• Localization, expression, and the role in fertilization of spermosin, an ascidian sperm trypsin-like protease

  H Sawada; K Iwasaki; F KiharaNegishi; H Ariga; H Yokosawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 222 2 499 - 504 1996年05月 [査読有り]
  
• MOLECULAR-CLONING OF THE COMPLEMENTARY-DNA FOR THE MOUSE PYRUVATE-KINASE M-2 GENE WHOSE EXPRESSION IS DEPENDENT UPON CELL-DIFFERENTIATION

  S IZUMI; A MANABE; A TOMOYASU; F KIHARANEGISHI; H ARIGA

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1267 2-3 135 - 138 1995年06月 [査読有り]
  
• IDENTIFICATION AND CDNA CLONING OF SINGLE-STRANDED-DNA BINDING-PROTEINS THAT INTERACT WITH THE REGION UPSTREAM OF THE HUMAN C-MYC GENE

  Y NEGISHI; Y NISHITA; Y SAEGUSA; KAKIZAKI, I; GALLI, I; F KIHARA; K TAMAI; N MIYAJIMA; SMM IGUCHIARIGA; H ARIGA

  ONCOGENE 9 4 1133 - 1143 1994年04月 [査読有り]
  
• CELL CYCLE-DEPENDENT ACTIVATION OF C-MYC ENHANCER

  KAKIZAKI, I; Y IMAMURA; GALLI, I; F KIHARA; H ARIGA; SMM IGUCHIARIGA

  INTERNATIONAL JOURNAL OF ONCOLOGY 2 4 657 - 661 1993年04月 [査読有り]
  
• c-myc protein complex binds to two sites in human hsp70 promoter region.

  Taira T; Negishi Y; Kihara F; Iguchi-Ariga SM; Ariga H

  Biochimica et biophysica acta 1130 166 - 174 2 1992年03月 [査読有り]
  
• A EUKARYOTIC NUCLEAR-PROTEIN OF 130 KDA BINDS TO A BACTERIAL CAMP RESPONSIVE ELEMENT

  F KIHARA; H ARIGA

  BIOCHIMICA ET BIOPHYSICA ACTA 1089 2 227 - 233 1991年06月 [査読有り]
  
• EVENTS BLOCKED IN PREREPLICATIVE PHASE IN SENESCENT HUMAN-DIPLOID CELLS, TIG-1, FOLLOWING SERUM STIMULATION

  F KIHARA; Y TSUJI; M MIURA; S ISHIBASHI; T IDE

  MECHANISMS OF AGEING AND DEVELOPMENT 37 2 103 - 117 1986年12月 [査読有り]
  
• FAILURE IN S6 PROTEIN-PHOSPHORYLATION BY SERUM STIMULATION OF SENESCENT HUMAN-DIPLOID FIBROBLASTS, TIG-1

  F KIHARA; J NINOMIYATSUJI; S ISHIBASHI; T IDE

  MECHANISMS OF AGEING AND DEVELOPMENT 37 1 27 - 40 1986年11月 [査読有り]
  
• [Case of Recklinghausen's disease presenting as acute porphyria in the terminal stage].

  Kihara F; Inoue Y; Arima I; Ono M; Masumoto H

  Naika. Internal medicine 18 381 - 387 2 1966年08月 [査読有り]
  
• [A case of plane vertebra, calve].

  KAMIURA T; ARIMA I; KIHARA F; ONO M; MATSUMOTO D

  Nagasaki Igakkai zasshi = Nagasaki medical journal 37 242 - 243 1962年09月 [査読有り]
  
• [A case of hemochromatosis associated with aplastic anemia].

  KIHARA F; ARIMA I; ONO M; KAMIURA T; KIDO T

  Nagasaki Igakkai zasshi = Nagasaki medical journal 37 130 - 136 1962年07月 [査読有り]
  

MISC

• P2-013 医療機器回収情報の調査とその考察 : 医療機器回収の二次情報の構築(一般演題 ポスター発表,医薬品情報・データベース,医療薬学の創る未来 科学と臨床の融合)

  曽賀 千智; 根岸 文子; 入野 洋輔; 佐生 奈美枝; 河野 博充; 江戸 清人 日本医療薬学会年会講演要旨集 19 389 -389 2009年09月
• 20E-05 リマプロスト製剤の先発品と後発品における品質および安定性に関する検討(後発医薬品,来るべき時代への道を拓く)

  兜坂 正史; 江戸 清人; 根岸 文子; 丸山 桂司; 河野 博充 日本医療薬学会年会講演要旨集 18 254 -254 2008年09月
• 29-P1-160 日本人末梢血中のCYP2D6mRNA発現量に及ぼす*10の影響(TDM/薬物動態,社会の期待に応える医療薬学を)

  根岸 文子; 奥山 ゆず香; 柳 真志帆; 本間 真人; 土岐 浩介; 幸田 幸直; 原 宏和; 成松 鎭雄; 渡邊 真知子 日本医療薬学会年会講演要旨集 17 243 -243 2007年09月
• 29-P1-167 降圧作用を有する特定保健用食品とCa拮抗薬との相互作用の解析(TDM/薬物動態,社会の期待に応える医療薬学を)

  笹生 瑛子; 根岸 文子; 壺河 秀鷹; 柳 真志帆; 中村 ひろみ; 栗原 順一; 鈴木 重人; 中込 和哉; 江戸 清人; 黄倉 崇; 出口 芳春; 渡邊 真知子 日本医療薬学会年会講演要旨集 17 244 -244 2007年09月
• 01P2-028 末梢血中CYP2D6のmRNA定量における臨床的意義の解析(薬物療法(基礎と臨床),医療薬学の扉は開かれた)

  奥山 ゆず香; 根岸 文子; 本間 真人; 土岐 浩介; 幸田 幸直; 渡邊 真知子 日本医療薬学会年会講演要旨集 16 522 -522 2006年09月