Negishi Fumiko

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Associate Professor
Graduate School of Pharmaceutical Sciences Associate Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201401083584807114

J-Global ID

• 201401083584807114

Research Interests

• adipocytokine   inflammation   obesity   adipogenesis   sialidase   PU.1   分化   転写因子   白血病   赤白血病   赤白血球   転写調節   血液細胞分化   リン酸化   アセチル化   胚性腫瘍細胞   アポトーシス   細胞分化   細胞増殖   マウス赤白血病(MEL)   Ets   血球分化   がん遺伝子   HDAC   分化のスイッチ   骨髄球   T細胞   SV40   Etsファミリー転写因子   機能的相互作用   lck   Defferential Display法   CKLiK   複製   Diffrential Display法   

Research Areas

• Life sciences / Hematology and oncology
• Life sciences / Experimental pathology
• Life sciences / Developmental biology

Academic & Professional Experience

• 2012/04  Teikyo UniversityFaculty of Pharma-Science

Research Activity Information

Published Papers

• Effects of fermented rice vinegar Kurozu and its sediment on inflammation-induced plasminogen activator 1 (PAI-1) increase.

  N. Ohkura N; Kihara-Negishi F. Fujii A; Kanouchi H; Oishi K; Atsumi G; Nagano M

  Food and Nutrition Sciences 9 (3) 235 - 246 2018 [Refereed]
  
• NEU1 sialidase controls gene expression and secretion of IL-6 and MCP-1 through NF-kappa B pathway in 3T3-L1 adipocytes

  Yujin Natori; Miwako Nasui; Kiyoto Edo; Shogo Sato; Takuya Sakurai; Takako Kizaki; Fumiko Kihara-Negishi

  JOURNAL OF BIOCHEMISTRY 162 (2) 137 - 143 0021-924X 2017/08 [Refereed]
  
• Neu1 sialidase interacts with perilipin 1 on lipid droplets and inhibits lipolysis in 3T3-L1 adipocytes

  Yujin Natori; Miwako Nasui; Fumiko Kihara-Negishi

  GENES TO CELLS 22 (5) 485 - 492 1356-9597 2017/05 [Refereed]
  
• Simultaneous determination of catechins and caffeine in green tea-based beverages and foods for specified health uses.

  K. Maruyama; F. Kihara-Negishi; N. Okura; Y. Nakamura; M. Nasui; M. Saito

  Food and Nutrition Sciences 8 Scientific Research Publishing, Inc. 8 (3) 316 - 325 2157-944X 2017 [Refereed]
  
• Effects of a diet containing Brazilian propolis on lipopolysaccharideinduced increases in plasma plasminogen activator inhibitor-1 levels in mice

  Naoki Ohkura; Katsutaka Oishi; Fumiko Kihara-Negishi; Gen-Ichi Atsumi; Tomoki Tatefuji

  Journal of Intercultural Ethnopharmacology eJManager LLC 5 (4) 439 - 443 2146-8397 2016 [Refereed]
  
• Comparison of Quality and Stability of limaprost-alfadex Generics against Branded Products.

  Fumiko Negishi

  Jan. J. Pharm. Health Care Sci. 36 143 - 149 2010 [Refereed]
  
• Quantification of the Levels of CYP2D6 mRNA in Peripheral Blood Leukocytes by Reverse Transcriptase Polymerase Chain Reaction HPLC

  Satoko Nagano; Hiroyuki Hosono; Fumiko Negishi; Mashiho Yanagi; Masato Homma; Yukinao Kohda; Machiko Watanabe

  CHEMICAL & PHARMACEUTICAL BULLETIN 57 (11) 1278 - 1281 0009-2363 2009/11 [Refereed]
  
• Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins

  Toshiyuki Yamada; Takeshi Shimizu; Takuya Sakurai; Naoki Nanashima; Fumiko Kihara-Negishi; Mitsuhiro Suzuki; Yang Fan; Miki Akita; Tsuneyuki Oikawa; Shigeki Tsuchida

  LEUKEMIA RESEARCH 33 (3) 483 - 489 0145-2126 2009/03 [Refereed]
  
• Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells

  Toshiyuki Yamada; Takeshi Shimizu; Mitsuhiro Suzuki; Fumiko Kihara-Negishi; Naoki Nanashima; Takuya Sakurai; Yang Fan; Miki Akita; Tsuneyuki Oikawa; Shigeki Tsuchida

  EXPERIMENTAL CELL RESEARCH 314 (4) 847 - 858 0014-4827 2008/02 [Refereed]
  
• Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy

  Takuya Sakurai; Nobuo Kondoh; Masaaki Arai; Jun-Ichi Hamada; Toshiyuki Yamada; Fumiko Kihara-Negishi; Tetsuya Izawa; Hideki Ohno; Mikio Yamamoto; Tsuneyuki Oikawa

  CANCER SCIENCE 98 (11) 1775 - 1784 1347-9032 2007/11 [Refereed]
  
• Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression

  Y. Nakazawa; M. Suzuki; N. Manabe; T. Yamada; F. Kihara-Negishi; T. Sakurai; D. G. Tenen; A. Iwama; M. Mochizuki; T. Oikawa

  ONCOGENE 26 (24) 3541 - 3550 0950-9232 2007/05 [Refereed]
  
• Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b

  M Suzuki; T Yamada; F Kihara-Negishi; T Sakurai; E Hara; DG Tenen; N Hozumi; T Oikawa

  ONCOGENE 25 (17) 2477 - 2488 0950-9232 2006/04 [Refereed]
  
• Classification of neural differentiation-associated genes in P19 embryonal carcinoma cells by their expression patterns induced after cell aggregation and/or retinoic acid treatment

  S Teramoto; F Kihara-Negishi; T Sakurai; T Yamada; T Hashimoto-Tamaoki; S Tamura; S Kohno; T Oikawa

  ONCOLOGY REPORTS 14 (5) 1231 - 1238 1021-335X 2005/11 [Refereed]
  
• Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain

  F Kihara-Negishi; M Suzuki; T Yamada; T Sakurai; T Oikawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 335 (2) 477 - 484 0006-291X 2005/09 [Refereed]
  
• Oikawa T, Yamada T, Kihara-Negishi F, Sakurai T. Ets family of transcriotion factors in normal hematopoiesis and in leukemogenesis.

  Oikawa T; Yamada T; Kihara-Negishi F; Sakurai T

  25 119 - 148 2005 [Refereed]
  
• Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells

  T Yamada; M Suzuki; H Satoh; F Kihara-Negishi; H Nakano; T Oikawa

  EXPERIMENTAL CELL RESEARCH 294 (1) 39 - 50 0014-4827 2004/03 [Refereed]
  
• Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression

  M Suzuki; T Yamada; F Kihara-Negishi; T Sakurai; T Oikawa

  ONCOGENE 22 (54) 8688 - 8698 0950-9232 2003/11 [Refereed]
  
• Effects of overexpression of the Ets family transcription factor TEL on cell growth and differentiation of K562 cells

  T Sakurai; T Yamada; F Kihara-Negishi; S Teramoto; Y Sato; T Izawa; T Oikawa

  INTERNATIONAL JOURNAL OF ONCOLOGY 22 (6) 1327 - 1333 1019-6439 2003/06 [Refereed]
  
• Prevention of PU.1-induced growth inhibition and apoptosis but not differentiation block in murine erythroleukemia cells by overexpression of CBP

  N Manabe; H Yamamoto; T Yamada; F Kihara-Negishi; Y Hashimoto; M Mochizuki; T Oikawa

  INTERNATIONAL JOURNAL OF ONCOLOGY 22 (6) 1345 - 1350 1019-6439 2003/06 [Refereed]
  
• Effects of overexpression of the Ets family transcription factor TEL on cell growth and differentiation of K562.

  Sakurai T; Yamada T; Kihara-Negishi F; Teramoto S; Sato Y; Izawa T; Oikawa T

  Int J Oncology. 22 1327 - 1333 2003 [Refereed]
  
• Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb.

  Yamamoto H; Kihara-Negishi F; Yamada T; Suzuki M; Nakano T; Oikawa T

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2 13 69 - 75 1044-9523 2002/02 [Refereed]
  
• Extinction of expression of the genes encoding haematopoietic cell-restricted transcription factors in T-lymphoma x fibroblast cell hybrids

  T Oikawa; T Yamada; N Kondoh; F Negishi-Kihara; Y Hitomi; M Suzuki; S Teramoto

  IMMUNOLOGY 104 (2) 162 - 167 0019-2805 2001/10 [Refereed]
  
• In vivo complex formation of PU.1 with HDAC1 associated with PU.1-mediated transcriptional repression

  F Kihara-Negishi; H Yamamoto; M Suzuki; T Yamada; T Sakurai; T Tamura; T Oikawa

  ONCOGENE 20 (42) 6039 - 6047 0950-9232 2001/09 [Refereed]
  
• Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells

  T Yamada; M Abe; T Higashi; H Yamamoto; F Kihara-Negishi; T Sakurai; T Shirai; T Oikawa

  BLOOD 97 (8) 2300 - 2307 0006-4971 2001/04 [Refereed]
  
• The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis

  T Oikawa; T Yamada; F Kihara-Negishi; H Yamamoto; N Kondoh; Y Hitomi; Y Hashimoto

  CELL DEATH AND DIFFERENTIATION 6 (7) 599 - 608 1350-9047 1999/07 [Refereed]
  
• Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP

  H Yamamoto; F Kihara-Negishi; T Yamada; Y Hashimoto; T Oikawa

  ONCOGENE 18 (7) 1495 - 1501 0950-9232 1999/02 [Refereed]
  
• Reduction of DNA binding activity of the GATA-1 transcription factor in the apoptotic process induced by overexpression of PU.1 in murine erythroleukemia cells

  T Yamada; F Kihara-Negishi; H Yamamoto; M Yamamoto; Y Hashimoto; T Oikawa

  EXPERIMENTAL CELL RESEARCH 245 (1) 186 - 194 0014-4827 1998/11 [Refereed]
  
• Enhanced expression of the urokinase-type plasminogen activator gene and reduced colony formation in soft agar by ectopic expression of PU.1 in HT1080 human fibrosarcoma cells

  N Kondoh; T Yamada; F Kihara-Negishi; M Yamamoto; T Oikawa

  BRITISH JOURNAL OF CANCER 78 (6) 718 - 723 0007-0920 1998/09 [Refereed]
  
• Down-regulation of c-myc and bcl-2 gene expression in PU.1-induced apoptosis in murine erythroleukemia cells

  F Kihara-Negishi; T Yamada; Y Kubota; N Kondoh; H Yamamoto; M Abe; T Shirai; Y Hashimoto; T Oikawa

  INTERNATIONAL JOURNAL OF CANCER 76 (4) 523 - 530 0020-7136 1998/05 [Refereed]
  
• Localization, expression, and the role in fertilization of spermosin, an ascidian sperm trypsin-like protease

  H Sawada; K Iwasaki; F KiharaNegishi; H Ariga; H Yokosawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 222 (2) 499 - 504 0006-291X 1996/05 [Refereed]
  
• MOLECULAR-CLONING OF THE COMPLEMENTARY-DNA FOR THE MOUSE PYRUVATE-KINASE M-2 GENE WHOSE EXPRESSION IS DEPENDENT UPON CELL-DIFFERENTIATION

  S IZUMI; A MANABE; A TOMOYASU; F KIHARANEGISHI; H ARIGA

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1267 (2-3) 135 - 138 0167-4889 1995/06 [Refereed]
  
• IDENTIFICATION AND CDNA CLONING OF SINGLE-STRANDED-DNA BINDING-PROTEINS THAT INTERACT WITH THE REGION UPSTREAM OF THE HUMAN C-MYC GENE

  Y NEGISHI; Y NISHITA; Y SAEGUSA; KAKIZAKI, I; GALLI, I; F KIHARA; K TAMAI; N MIYAJIMA; SMM IGUCHIARIGA; H ARIGA

  ONCOGENE 9 (4) 1133 - 1143 0950-9232 1994/04 [Refereed]
  
• CELL CYCLE-DEPENDENT ACTIVATION OF C-MYC ENHANCER

  KAKIZAKI, I; Y IMAMURA; GALLI, I; F KIHARA; H ARIGA; SMM IGUCHIARIGA

  INTERNATIONAL JOURNAL OF ONCOLOGY 2 (4) 657 - 661 1019-6439 1993/04 [Refereed]
  
• c-myc protein complex binds to two sites in human hsp70 promoter region.

  Taira T; Negishi Y; Kihara F; Iguchi-Ariga SM; Ariga H

  Biochimica et biophysica acta 2 1130 166 - 174 0006-3002 1992/03 [Refereed]
  
• A EUKARYOTIC NUCLEAR-PROTEIN OF 130 KDA BINDS TO A BACTERIAL CAMP RESPONSIVE ELEMENT

  F KIHARA; H ARIGA

  BIOCHIMICA ET BIOPHYSICA ACTA 1089 (2) 227 - 233 0006-3002 1991/06 [Refereed]
  
• EVENTS BLOCKED IN PREREPLICATIVE PHASE IN SENESCENT HUMAN-DIPLOID CELLS, TIG-1, FOLLOWING SERUM STIMULATION

  F KIHARA; Y TSUJI; M MIURA; S ISHIBASHI; T IDE

  MECHANISMS OF AGEING AND DEVELOPMENT 37 (2) 103 - 117 0047-6374 1986/12 [Refereed]
  
• FAILURE IN S6 PROTEIN-PHOSPHORYLATION BY SERUM STIMULATION OF SENESCENT HUMAN-DIPLOID FIBROBLASTS, TIG-1

  F KIHARA; J NINOMIYATSUJI; S ISHIBASHI; T IDE

  MECHANISMS OF AGEING AND DEVELOPMENT 37 (1) 27 - 40 0047-6374 1986/11 [Refereed]
  
• [Case of Recklinghausen's disease presenting as acute porphyria in the terminal stage].

  Kihara F; Inoue Y; Arima I; Ono M; Masumoto H

  Naika. Internal medicine 2 18 381 - 387 0022-1961 1966/08 [Refereed]
  
• [A case of plane vertebra, calve].

  KAMIURA T; ARIMA I; KIHARA F; ONO M; MATSUMOTO D

  Nagasaki Igakkai zasshi = Nagasaki medical journal 37 242 - 243 0369-3228 1962/09 [Refereed]
  
• [A case of hemochromatosis associated with aplastic anemia].

  KIHARA F; ARIMA I; ONO M; KAMIURA T; KIDO T

  Nagasaki Igakkai zasshi = Nagasaki medical journal 37 130 - 136 0369-3228 1962/07 [Refereed]
  

MISC

• P2-013 医療機器回収情報の調査とその考察 : 医療機器回収の二次情報の構築(一般演題 ポスター発表,医薬品情報・データベース,医療薬学の創る未来 科学と臨床の融合)

  曽賀 千智; 根岸 文子; 入野 洋輔; 佐生 奈美枝; 河野 博充; 江戸 清人  日本医療薬学会年会講演要旨集  19-  389  -389  2009/09
• 20E-05 リマプロスト製剤の先発品と後発品における品質および安定性に関する検討(後発医薬品,来るべき時代への道を拓く)

  兜坂 正史; 江戸 清人; 根岸 文子; 丸山 桂司; 河野 博充  日本医療薬学会年会講演要旨集  18-  254  -254  2008/09
• 29-P1-160 日本人末梢血中のCYP2D6mRNA発現量に及ぼす*10の影響(TDM/薬物動態,社会の期待に応える医療薬学を)

  根岸 文子; 奥山 ゆず香; 柳 真志帆; 本間 真人; 土岐 浩介; 幸田 幸直; 原 宏和; 成松 鎭雄; 渡邊 真知子  日本医療薬学会年会講演要旨集  17-  243  -243  2007/09
• 29-P1-167 降圧作用を有する特定保健用食品とCa拮抗薬との相互作用の解析(TDM/薬物動態,社会の期待に応える医療薬学を)

  笹生 瑛子; 根岸 文子; 壺河 秀鷹; 柳 真志帆; 中村 ひろみ; 栗原 順一; 鈴木 重人; 中込 和哉; 江戸 清人; 黄倉 崇; 出口 芳春; 渡邊 真知子  日本医療薬学会年会講演要旨集  17-  244  -244  2007/09
• 01P2-028 末梢血中CYP2D6のmRNA定量における臨床的意義の解析(薬物療法(基礎と臨床),医療薬学の扉は開かれた)

  奥山 ゆず香; 根岸 文子; 本間 真人; 土岐 浩介; 幸田 幸直; 渡邊 真知子  日本医療薬学会年会講演要旨集  16-  522  -522  2006/09