Matsumura Nobuko

Researcher Information

Affiliation

Preclinical Medicine Senior Assistant Professor
Department of Pharmacology Senior Assistant Professor

Degree

• (BLANK)

Research Interests

• neuronal protection   プリン体   glutathione   bone marrow mesenchymal stem cell   neurodegenerative disease   microRNA   

Research Areas

• Life sciences / Pharmacology
• Life sciences / Neuroscience - general

Academic & Professional Experience

• 2023/04 - Today  Teikyo UniversitySenior Assistant Professor
• 2023 - Today  University of Human Arts and Sciences
• 2007/04 - 2023/03  Teikyo UniversitySchool of Medicine
• 1999/04 - 2007/03  Teikyo UniversitySchool of Medicine

Association Memberships

• 日本生化学会   日本薬理学会   

Research Activity Information

Published Papers

• Increased Brain Glutathione Levels by Intranasal Insulin Administration

  Taisuke Kawashima; Wattanaporn Bhadhprasit; Nobuko Matsumura; Chisato Kinoshita; Koji Aoyama

  Current Issues in Molecular Biology MDPI AG 47 (4) 284 - 284 2025/04 [Refereed]
  
• Erythroid Differentiation Regulator 1 as a Regulator of Neuronal GSH Synthesis

  Wattanaporn Bhadhprasit; Chisato Kinoshita; Nobuko Matsumura; Koji Aoyama

  Antioxidants MDPI AG 13 (7) 771 - 771 2024/06 [Refereed]
  
• Glutathione-Mediated Neuroprotective Effect of Purine Derivatives.

  Nobuko Matsumura; Koji Aoyama

  International journal of molecular sciences 24 (17) 2023/08 [Refereed]
  
• A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis.

  Nobuko Matsumura; Chisato Kinoshita; Wattanaporn Bhadhprasit; Toshio Nakaki; Koji Aoyama

  Journal of pharmacological sciences 151 (1) 37 - 45 2023/01 [Refereed]
  
• Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression.

  Chisato Kinoshita; Kazue Kikuchi-Utsumi; Koji Aoyama; Ryo Suzuki; Yayoi Okamoto; Nobuko Matsumura; Daiki Omata; Kazuo Maruyama; Toshio Nakaki

  Communications biology 4 (1) 182 - 182 2021/02 [Refereed]
  
• Mechanism of glutathione production in neurons

  Nobuko Matsumura; Chisato Kinoshita; Koji Aoyama

  Folia Pharmacologica Japonica 156 (1) 26 - 30 0015-5691 2021 [Refereed]
  
• GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin.

  Aoyama K; Bhadhprasit W; Watabe M; Wang F; Matsumura N; Nakaki T

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32 (1) 330 - 341 0892-6638 2017/09 [Refereed]
  
• Isobolographic analysis of the mechanisms of action of anticonvulsants from a combination effect

  Nobuko Matsumura; Toshio Nakaki

  EUROPEAN JOURNAL OF PHARMACOLOGY 741 237 - 246 0014-2999 2014/10 [Refereed]
  
• Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels

  Chisato Kinoshita; Koji Aoyama; Nobuko Matsumura; Kazue Kikuchi-Utsumi; Masahiko Watabe; Toshio Nakaki

  NATURE COMMUNICATIONS 5 3823  2041-1723 2014/05 [Refereed]
  
• Involvement of the α(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats.

  Kikuchi-Utsumi K; Ishizaka M; Matsumura N; Watabe M; Aoyama K; Sasakawa N; Nakaki T

  Neurotoxicity research 2 24 130 - 138 1029-8428 2013/08 [Refereed]
  
• Anticonvulsant action of indazole.

  Nobuko Matsumura; Kazue Kikuchi-Utsumi; Kentaro Sakamaki; Masahiko Watabe; Koji Aoyama; Toshio Nakaki

  Epilepsy research 3 104 (3) 203 - 16 0920-1211 2013/05 [Refereed]
  
• Alpha_1A-adrenergic control of piloerection and palpebral fissure width in rats.

  Kikuchi-Utsumi K; Ishizaka M; Matsumura N; Nakaki T

  Autonomic neuroscience : basic & clinical 179 (1-2) 148 - 150 1566-0702 2013/05 [Refereed]
  
• Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.

  Aoyama K; Wang F; Matsumura N; Kiyonari H; Shioi G; Tanaka K; Kinoshita C; Kikuchi-Utsumi K; Watabe M; Nakaki T

  Neurobiology of disease 45 (3) 973 - 982 0969-9961 2012/03 [Refereed]
  
• Caffeine and uric acid mediate glutathione synthesis for neuroprotection.

  Aoyama K; Matsumura N; Watabe M; Wang F; Kikuchi-Utsumi K; Nakaki T

  Neuroscience 181 (5) 206 - 215 1873-7544 2011/05 [Refereed]
  
• Activities of 7-nitroindazole and 1-(2-(trifluoromethylphenyl)-imidazole independent of neuronal nitric-oxide synthase inhibition.

  Matsumura N; Kikuchi-Utsumi K; Nakaki T

  The Journal of pharmacology and experimental therapeutics 2 325 357 - 362 0022-3565 2008/05 [Refereed]
  
• Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction.

  Aoyama K; Matsumura N; Watabe M; Nakaki T

  The European journal of neuroscience 1 27 20 - 30 0953-816X 2008/01 [Refereed]
  
• Nigrostriatal pathway laterality in unlesioned old female rats

  Mishima A; Fujii T; Matsumura N; Maruyama D; Hishikawa K; Nakaki T

  Neuroscience Research Communications 30 (2) 63 - 70 2002/04 [Refereed]
  
• Effects of nicotine on motor activity, passive avoidance and plus-maze behavior in aged NMRI and C57BL mice

  Akira Mishima; Tomoko Fujii; Nobuko Matsumura; Daisuke Maruyama; Keiichi Hishikawa; Toshio Nakaki

  Neuroscience Research Communications 30 (2) 91 - 101 0893-6609 2002/01 [Refereed]
  
• Glufosinate ammonium induces convulsion through N-methyl-D-aspartate receptors in mice

  Matsumura N; Takeuchi C; Hishikawa K; Fujii T; Nakaki T

  Neuroscience Letters 304 (1-2) 123 - 125 2001/05 [Refereed]
  
• Involvement of cytosolic NAD+ glycohydrolase in cyclic ADP-ribose metabolism.

  Matsumura N; Tanuma S

  Biochem Biophys Res Commun 253 (2) 246 - 252 1998/12 [Refereed]
  
• Role of (ADP-ribose)n catabolism in DNA repair.

  Maruta H; Matsumura N; Tanuma S

  Biochem Biophys Res Commun 236 (2) 265 - 269 1997/07 [Refereed]
  

Conference Activities & Talks

• Learning Outcomes with Flipped Classroom using the Educational Support System (Prime Learning).

  青山晃治; 松村暢子

  医学教育  2024

MISC

• Involvement of brain arginine increase in glufosinate ammonium-induced delayed convulsion

  N Matsumura; M Okanaga; T Nakaki  JOURNAL OF PHARMACOLOGICAL SCIENCES  97-  260P  -260P  2005
• Mechanisms underlying glufosinate-ammonium-induced delayed convulsion

  N Matsumura; M Ishizaka; T Nakaki  JOURNAL OF PHARMACOLOGICAL SCIENCES  94-  166P  -166P  2004
• Decrease in brain glutamate content during glufosinate ammonium-induced convulsion in mouse.

  N Matsumura; M Ishizaka; K Hishikawa; T Fujii; T Nakaki  JOURNAL OF PHARMACOLOGICAL SCIENCES  91-  204P  -204P  2003