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Hirasawa Takae
Department of Biosciences Associate Professor
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J-Global ID
Research Interests
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Academic & Professional Experience
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Last Updated :2024/04/14
Researcher Information
Affiliation
Department of Biosciences Associate Professor
URL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201801008188083764
Research funding number
10402083
J-Global ID
201801008188083764
Research Interests
synapse formation Maternal and postnatal stress microglia
Research Areas
Life sciences / Neuroscience - general
Academic & Professional Experience
2014/04 - Today Teikyo UniversityFaculty of Science and Engineering Department of Biosciences
2014/04 - 2018/03 Teikyo UniversityFaculty of Science and Engineering Department of Biosciences
2007/03 - 2014/03 University of YamanashiDepartment of Research Interdisciplinary Graduate School of Medicine and Engineering
2005/04 - 2014/03 University of YamanashiDepartment of Research Interdisciplinary Graduate School of Medicine and Engineering
2000/04 - 2005/03 National Center of Neurology and PsychiatryNational Institute of Neuroscience, Ncnp
1999/04 - 2000/03 Tokai UniversitySchool of Medicine
Research Activity Information
Published Papers
The developmental brain function and microglia function by prenatal or postnatal stress
Takae Hirasawa
Jap.J.Stress.Sci 36 (1) 22 - 34 2021/09
[Invited]
Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome
AYamada,THirasawa; KNishimura; CShimura,NKogo; KFukuda; MKato; MYokomori; THayashi; MUmeda,MYoshimura,YIwakura; INikaido; SiItohara; YShinkai
iScience 24 (7) 102741 - 102741 2021/07
[Refereed]
自閉症関連分子SHANK3アイソフォームにおけるスプライシングバリアントの解析
横森 将輝; 和賀 央子; 清水 仁美; 平澤 孝枝; 内野 茂夫
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 日本臨床精神神経薬理学会・日本神経精神薬理学会 28回・48回 214 - 214 2018/11
ネオニコチノイド系薬剤がマウスの脳に対するゲノムDNAのメチル化および遺伝子発現におよぼす影響について
清水 仁美; 和賀 央子; 横森 将輝; 大沼 一富; 平澤 孝枝; 内野 茂夫
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 日本臨床精神神経薬理学会・日本神経精神薬理学会 28回・48回 223 - 223 2018/11
Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny
Tamio Furuse; Kunio Miyake; Takashi Kohda; Hideki Kaneda; Takae Hirasawa; Ikuko Yamada; Tomoko Kushida; Misho Kashimura; Kimio Kobayashi; Fumitoshi Ishino; Takeo Kubota; Shigeharu Wakana
Genes and Nutrition BioMed Central Ltd. 12 (1) 1 1865-3499 2017/01
[Refereed]
Maternal restraint stress during pregnancy in mice induces 11β-HSD1-associated metabolic changes in the livers of the offspring
H. Maeyama; T. Hirasawa; Y. Tahara; C. Obata; H. Kasai; K. Moriishi; K. Mochizuki; T. Kubota
Journal of Developmental Origins of Health and Disease Cambridge University Press 6 (2) 105 - 114 2040-1752 2015/12
[Refereed]
Long-term imipramine treatment increases N-methyl-D-aspartate receptor activity and expression via epigenetic mechanisms
Nguyen An Nghia; Takae Hirasawa; Hirotake Kasai; Chie Obata; Kohji Moriishi; Kazuki Mochizuki; Schuichi Koizumi; Takeo Kubota
EUROPEAN JOURNAL OF PHARMACOLOGY ELSEVIER SCIENCE BV 752 69 - 77 0014-2999 2015/04
[Refereed]
The epigenome in neurological disorders: A new marker for understanding neuronal dysfunction
Takeo Kubota; Takae Hirasawa; Kunio Miyake
Brain and Nerve Igaku-Shoin Ltd 66 (5) 591 - 597 1881-6096 2014
[Refereed]
Mental Disorders and Transgenerational Epigenetics
Takeo Kubota; Takae Hirasawa; Kunio Miyake
Transgenerational Epigenetics Elsevier Inc. 343 - 354 2014
[Refereed]
Role of epigenetics in Rett syndrome
Takeo Kubota; Kunio Miyake; Takae Hirasawa
Epigenomics 5 (5) 583 - 592 1750-1911 2013/10
[Refereed]
Comparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome
Kunio Miyake; Chunshu Yang; Yohei Minakuchi; Kenta Ohori; Masaki Soutome; Takae Hirasawa; Yasuhiro Kazuki; Noboru Adachi; Seiko Suzuki; Masayuki Itoh; Yu-ichi Goto; Tomoko Andoh; Hiroshi Kurosawa; Mitsuo Oshimura; Masayuki Sasaki; Atsushi Toyoda; Takeo Kubota
PLOS ONE PUBLIC LIBRARY SCIENCE 8 (6) e66729 1932-6203 2013/06
[Refereed]
Epigenetic mechanisms and therapeutic perspectives for neurodevelopmental disorders
Takeo Kubota; Hirasawa Takae; Kunio Miyake
Pharmaceuticals 5 (4) 369 - 383 1424-8247 2012/04
[Refereed]
EPIGENETICS IN AUTISM AND OTHER NEURODEVELOPMENTAL DISEASES
Kunio Miyake; Takae Hirasawa; Tsuyoshi Koide; Takeo Kubota
NEURODEGENERATIVE DISEASES SPRINGER 724 91 - 98 0065-2598 2012
[Refereed]
Epigenetic understanding of gene-environment interactions in psychiatric disorders: A new concept of clinical genetics
Takeo Kubota; Kunio Miyake; Takae Hirasawa
Clinical Epigenetics 4 (1) 1 1868-7075 2012
[Refereed]
Epigenetic Modulation of Human Neurobiological Disorders
Takeo Kubota; Kunio Miyake; Takae Hirasawa; Tatsushi Onaka; Hidenori Yamasue
Epigenetics in Human Disease Elsevier Inc. 193 - 203 2012
[Refereed]
The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome
Kunio Miyake; Takae Hirasawa; Masaki Soutome; Masayuki Itoh; Yu-ichi Goto; Kazushi Endoh; Kenichiro Takahashi; Shinichi Kudo; Takayuki Nakagawa; Sana Yokoi; Takahiro Taira; Johji Inazawa; Takeo Kubota
BMC NEUROSCIENCE BIOMED CENTRAL LTD 12 81 1471-2202 2011/08
[Refereed]
Inhibition of N-methyl-d-aspartate receptor activity resulted in aberrant neuronal migration caused by delayed morphological development in the mouse neocortex
S. Uchino; T. Hirasawa; H. Tabata; Y. Gonda; C. Waga; Y. Ondo; K. Nakajima; S. Kohsaka
Neuroscience 169 (2) 609 - 618 0306-4522 2010/08
[Refereed]
Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene-Environment Interactions
Takeo Kubota; Kunio Miyake; Takae Hirasawa; Kaoru Nagai; Tsuyoshi Koide
JOURNAL OF PHARMACOLOGICAL SCIENCES JAPANESE PHARMACOLOGICAL SOC 113 (1) 3 - 8 1347-8613 2010/05
[Refereed]
Transthyretin accelerates vascular Abeta deposition in a mouse model of Alzheimer's disease.
Henny Wati; Takeshi Kawarabayashi; Etsuro Matsubara; Ayumi Kasai; Takae Hirasawa; Takeo Kubota; Yasuo Harigaya; Mikio Shoji; Shuichiro Maeda
Brain pathology (Zurich, Switzerland) 19 (1) 48 - 57 1015-6305 2009/01
[Refereed]
Augmentation of polysialic acid by valproic acid in early postnatal mouse hippocampus and primary cultured hippocampal neurons
Takamitsu Natori; Fumiaki Kodaira; Takae Hirasawa; Yong Ying Gao; Kaoru Nagai
JOURNAL OF BIOSCIENCE AND BIOENGINEERING SOC BIOSCIENCE BIOENGINEERING JAPAN 105 (2) 164 - 167 1389-1723 2008/02
[Refereed]
Visualization of microgilia in living tissues using Iba1-EGFP transgenic mice
Takae Hirasawa; Shinichi Kohsaka
Brain and Nerve 59 (7) 763 - 772 0006-8969 2007/07
[Refereed]
Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor
S Uchino; H Wada; S Honda; Y Nakamura; Y Ondo; T Uchiyama; M Tsutsumi; E Suzuki; T Hirasawa; S Kohsaka
JOURNAL OF NEUROCHEMISTRY BLACKWELL PUBLISHING 97 (4) 1203 - 1214 0022-3042 2006/05
[Refereed]
Shank3はPSD-95とGluR1 AMPA受容体の相互作用をもたらす(Shank3 mediates interaction of PSD-95 and GluR1 AMPA receptor)
内野 茂夫; 和田 英則; 中村 泰子; 内山 孝由; 堤 も絵; 平澤 孝枝; 高坂 新一
神経化学 日本神経化学会 44 (2-3) 179 - 179 0037-3796 2005/08
Visualization of microglia in living tissues using Iba1-EGFP transgenic mice
T Hirasawa; K Ohsawa; Y Imai; Y Ondo; C Akazawa; S Uchino; S Kohsaka
JOURNAL OF NEUROSCIENCE RESEARCH WILEY-LISS 81 (3) 357 - 362 0360-4012 2005/08
[Refereed]
Iba1-EGFPトランスジェニックマウスの作製 ミクログリアの可視化技術の開発(Generation of Iba1-EGFP transgenic mouse: Visualization of microglia)
平澤 孝枝; 大澤 圭子; 今井 嘉紀; 内野 茂夫; 高坂 新一
神経化学 日本神経化学会 43 (2-3) 424 - 424 0037-3796 2004/08
Inhibition of NMDA receptors induces delayed neuronal maturation and sustained proliferation of progenitor cells during neocortical development
T Hirasawa; H Wada; S Kohsaka; S Uchino
JOURNAL OF NEUROSCIENCE RESEARCH WILEY-LISS 74 (5) 676 - 687 0360-4012 2003/12
[Refereed]
Slo2 sodium-activated K+ channels bind to the PDZ domain of PSD-95
S Uchino; H Wada; S Honda; T Hirasawa; S Yanai; Y Nakamura; Y Ondo; S Kohsaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 310 (4) 1140 - 1147 0006-291X 2003/10
[Refereed]
sodium-activated K+ channelであるSlo2はPSD-95のPDZドメインと結合する(Slo2, sodium-activated K+channel, binds to PDZ domain of PSD-95)
内野 茂夫; 和田 英則; 本田 静世; 平澤 孝枝; 柳内 茂樹; 中村 泰子; 恩藤 由美子; 高坂 新一
神経化学 日本神経化学会 42 (2-3) 300 - 300 0037-3796 2003/08
神経幹細胞分化時におけるNMDA受容体の機能解析
平澤 孝枝; 内野 茂夫; 本田 静世; 高坂 新一
神経組織の成長・再生・移植研究会学術集会プログラム・予稿集 神経組織の成長・再生・移植研究会 17回 44 - 44 2002/06
Effect of 1 alpha-hydroxyvitamin D-3 and egg-shell calcium on bone metabolism in ovariectomized osteoporotic model rats
T Hirasawa; N Omi; Ezawa, I
JOURNAL OF BONE AND MINERAL METABOLISM SPRINGER-VERLAG TOKYO 19 (2) 84 - 88 0914-8779 2001
[Refereed]
Adverse effects of an active fragment of parathyroid hormone on rat hippocampal organotypic cultures
T Hirasawa; T Nakamura; A Mizushima; M Morita; Ezawa, I; H Miyakawa; Y Kudo
BRITISH JOURNAL OF PHARMACOLOGY STOCKTON PRESS 129 (1) 21 - 28 0007-1188 2000/01
[Refereed]
Possible Mechanisms of Senile Dementia and Development of Their Protective and Treating Drugs
KUDO Yoshihisa; NAKAMURA Takeshi; NAKAMURA Kyoko; HIRASAWA Takae; EZAWA Ikuko
J. Mass Spectrom. Soc. Jpn. The Mass Spectrometry Society of Japan 47 (3) 110 - 114 1340-8097 1999/06
The advantage of alfacalcidol over vitamin D in the treatment of osteoporosis
A. Shiraishi; S. Higashi; H. Ohkawa; N. Kubodera; T. Hirasawa; I. Ezawa; K. Ikeda; E. Ogata
Calcified Tissue International 65 (4) 311 - 316 0171-967X 1999
[Refereed]
Activation of dihydropyridine sensitive Ca2+ channels in rat hippocampal neurons in culture by parathyroid hormone
Takae Hirasawa; Takeshi Nakamura; Mitsuhiro Morita; Ikuko Ezawa; Hiroyoshi Miyakawa; Yoshihisa Kudo
Neuroscience Letters 256 (3) 139 - 142 0304-3940 1998/11
[Refereed]
Actions of zinc on rapidly inactivating A-type and non-inactivating M- type potassium currents in bullfrog sympathetic neurons
Takae Hirasawa; Yoshihisa Kudo; Takayuki Tokimasa
Neuroscience Letters 255 (1) 5 - 8 0304-3940 1998/10
[Refereed]
Conference Activities & Talks
Temperature-dependent sexual differentiation mechanism in Japanese eel (Anguilla japonica)
平澤孝枝; 滝沢零士; 吉田 宰; 原秀磨; 夘月祥太
第44回日本分子生物学会 2021/12
The dynamics of microglia and stress tolerance in the brain during juvenile stress.
Takae Hirasawa
第36 回日本ストレス学会学術総会 2020/10
ヒストンリジンメチル化酵素調節に起因する自閉症モデルマウスの後天的治療法の可能性
平澤 孝枝
Conbio 2017 第40回 日本分子生物学会 2017/12
1. クリーフストラ症候群で見られる脳機能不全の後天的改善に向けて
山田亜夕美; 西村佳也子; 平澤孝枝; 眞貝洋一
第11回エピジェネティクス研究会年会 2017/05
H3K9メチル化酵素EHMT1の神経機能調節に伴うミクログリアの活性化
平澤孝枝; 山田亜夕美; 加藤まどか; 西村佳世子; 眞貝洋一; 久保田健夫
第11回エピジェネティクス研究会年会 2017/05
Proteasome activator 28γ specifically expressed in cerebellar Purkinje cells regulates neural function via ubiquitin histone H2A regulation.
HIRASAWA; Takae中村; 葛西 宏威; 天笠 太一; 齋藤 拓弥; 鶴岡 直人; 森石 恆司; 平澤 孝枝
第40回日本神経科学学会 2017
胎児期ストレスとエピジェネティクス変化
平澤孝枝
第2回日本DOHaD研究会 2014
MISC
自閉症関連分子SHANK3アイソフォームにおけるスプライシングバリアントの解析
横森将輝; 和賀央子; 清水仁美; 平澤孝枝; 内野茂夫 日本臨床精神神経薬理学会プログラム・抄録集 28th- 2018
ネオニコチノイド系薬剤がマウスの脳に対するゲノムDNAのメチル化および遺伝子発現におよぼす影響について
清水仁美; 和賀央子; 横森将輝; 大沼一富; 大沼一富; 平澤孝枝; 内野茂夫 日本臨床精神神経薬理学会プログラム・抄録集 28th- 2018
ネオニコチノイド系薬剤がマウスの脳に及ぼす影響
清水仁美; 和賀央子; 横森将輝; 平澤孝枝; 大沼一富; 大沼一富; 内野茂夫 日本分子生物学会年会プログラム・要旨集(Web) 41st- 2018
マウスモデルを用いたDOHaD仮説の実証 4:新規母体低栄養モデルマウスの開発
古瀬民生; 幸田尚; 三宅邦夫; 平澤孝枝; 串田知子; 山田郁子; 柏村実生; 金田秀貴; 小林喜美男; 石野史敏; 久保田健夫; 若菜茂晴 日本実験動物学会総会講演要旨集 62nd- 162 2015/04
Epigenetic understanding of neurodevelopmental disorders
久保田 健夫; 三宅 邦夫; 平澤 孝枝 発達障害研究 : 日本発達障害学会機関誌 35- (3) 204 -212 2013/08
Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics
Takeo Kubota; Kunio Miyake; Takae Hirasawa CLINICAL EPIGENETICS 4- 2012
自閉症とエピジェネティクス (特集 自閉症スペクトラムの生物学)
平澤 孝枝; 久保田 健夫 分子精神医学 11- (4) 289 -294 2011/10
The role of MeCP2 in neurodevelopmental disorders
Kunio Miyake; Takae Hirasawa; Takeo Kubota NEUROSCIENCE RESEARCH 71- E7 -E7 2011
Overview of epigenetics in neuroscience
Takeo Kubota; Takae Hirasawa NEUROSCIENCE RESEARCH 71- E6 -E6 2011
The increase of the expression of NMDA receptors is involved in the facilitative of calcium oscillation by corticosterone stimulation
Akira Endo; Takae Hirasawa; Kunio Miyake; Schuichi Koizumi; Takeo Kubota NEUROSCIENCE RESEARCH 71- E109 -E109 2011
Stress-Induce Genomic and Non-Genomic Changes related to Brain Function
Takae Hirasawa; Akira Endo; Kunio Miyake; Takeo Kubota GENES & GENETIC SYSTEMS 85- (6) 447 -447 2010/12
Corticosterone facilitates the glutamate receptors-dependent synchronized calcium oscillation in hippocampal neurons
Akira Endo; Takae Hirasawa; Kunio Miyake; Takeo Kubota NEUROSCIENCE RESEARCH 68- E229 -E229 2010
Abnormal epigenetic regulation in neurodevelopmental diseases
Takeo Kubota; Takae Hirasawa; Kazushi Endoh; Kaoru Nagai; Takahiro Taira JOURNAL OF PHARMACOLOGICAL SCIENCES 109- 42P -42P 2009
Visualization of microglia in living tissues using Iba1-EGFP transgenic mice
平澤 孝枝; 高坂 新一 Brain and nerve 59- (7) 763 -772 2007/07
知的発達障害とエピジェネティクスの分子遺伝学 (特集 精神疾患と知的発達障害の分子遺伝学)
平澤孝枝; 久保田健夫 神経研究の進歩 50- (5) 770 -779 2006/10
Overview of epigenetic neuroscience
Takeo Kubota; Takae Hirasawa; Kaoru Nagai NEUROSCIENCE RESEARCH 55- S36 -S36 2006
精神発達障害とエピジェネティクス (特集 エピジェネティクスとゲノム)
平澤 孝枝; 久保田 健夫 ゲノム医学 5- (5) 467 -472 2005/10
Visualization of microglia in IBA1-EGFP transgenic mice
S Uchino; T Hirasawa; S Kohsaka JOURNAL OF NEUROCHEMISTRY 94- 152 -153 2005/08
Analysis of MeCP2 expression in the central nervous system
S Uchino; M Tsutsumi; T Hirasawa; K Nagai; T Kubota; S Kohsaka JOURNAL OF PHARMACOLOGICAL SCIENCES 97- 218P -218P 2005
脳発達期におけるNMDA受容体の機能解析
平沢孝枝; 内野茂夫; 本田静世; 高坂新一 日本神経科学大会プログラム・抄録集 25th- 2002
NMDA受容体のキスカル酸に対する応答
伊藤公一; 内野茂夫; 平沢孝枝; 高坂新一; 工藤佳久 日本神経科学大会プログラム・抄録集 23rd- 2000
Research Grants & Projects
Elucidation of the mechanism of microglial polarity conversion by stress-induced mitophagy abnormalities.
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) :
2022/04 -2025/03
Author :
平澤 孝枝
an new approach the pathogenesis of mental retardation from the abnormality of microglia by postnatal mental stress.
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) :
2019/04 -2022/03
Author :
平澤 孝枝
二ホンウナギ(Anguilla japonica)の新奇養殖技術を目指した遺伝子制御機構の解明
大学コンソーシアムとちぎ:
大学を超えた共同研究支援事業
Date (from‐to) :
2017/09 -2018/09
ヒストンリジンメチル化制御系に基づく脳機 能の理解と治療戦略への展開
日本医療研究開発機構(AMED)革新的先端研究開発支援事業(AMED-CREST):
エピゲノム研究に基づく診断・治療へ向けた新技術の創出
Date (from‐to) :
2012/04 -2018/03
Elucidation of construction abnormality of brain cytokine network caused by juvenile stress
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) :
2014/04 -2017/03
Author :
HIRASAWA Takae
The epigenetic regulation of brain development by maternal stress
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) :
2011 -2013
Author :
HIRASAWA Takae; KUBOTA Takeo
The epigenetic mechanism of synaptic molecules in autism
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) :
2009 -2010
Author :
HIRASAWA Takae
The epigenetic regulation in infantile epilepsy
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) :
2006 -2008
Author :
HIRASAWA Takae
神経細胞の移動制御からみた小児性てんかんの病態解明
日本科学協会:
笹川科学研究助成
Date (from‐to) :
2006/04 -2007/03
ATPを介したニューロン・ミクログリア相互作用の分子基盤
日本学術振興会:
科学研究費助成事業 特定領域研究
Date (from‐to) :
2003 -2007
Author :
高坂 新一; 内野 茂夫; 大澤 圭子; 権田 裕子; 和賀 央子; 入野 康宏; 橋本 学; 奥野 孝枝; 神鳥 和代
Teaching Experience
Developmental bioligyDevelopmental bioligy
Basic of NeuroscienceBasic of Neuroscience