宮田　佳樹 (ミヤタ　ヨシキ)

研究者情報

所属

• 薬学部 准教授
• 大学院薬学研究科 准教授

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202401009172589572

J-Global ID

• 202401009172589572

研究分野

• ライフサイエンス / 食品科学

経歴

• 2018年04月 - 現在  帝京大学薬学部准教授
• 2013年04月 - 2018年03月  帝京大学薬学部講師
• 2007年04月 - 2013年03月  帝京大学薬学部助教
• 2006年04月 - 2007年03月  帝京大学薬学部助手

研究活動情報

論文

• Changes in Protein Expression in Warmed Human Lens Epithelium Cells Using Shotgun Proteomics.

  Hiroko Otake; Tetsushi Yamamoto; Naoki Yamamoto; Yosuke Nakazawa; Yoshiki Miyata; Atsushi Taga; Hiroshi Sasaki; Noriaki Nagai

  Medicina (Kaunas, Lithuania) 61 2 2025年02月
• Semiquantitative analysis of protein expression in heated rat lens using shotgun proteomics.

  Hiroko Otake; Shuya Masuda; Tetsushi Yamamoto; Yoshiki Miyata; Yosuke Nakazawa; Naoki Yamamoto; Atsushi Taga; Hiroshi Sasaki; Noriaki Nagai

  Molecular medicine reports 31 1 2025年01月
• Dilation of porcine retinal arterioles to nobiletin, a polymethoxyflavonoid: Roles of nitric oxide and voltage-dependent potassium channel

  Masahisa Watanabe; Yoshiki Miyata; Akira Ohno; Harumasa Yokota; Koyo Takase; Junya Hanaguri; Akifumi Kushiyama; Satoru Yamagami; Seiyo Harino; Taiji Nagaoka

  Experimental Eye Research 233 109548 - 109548 2023年08月
• Isolation and identification of the new baicalin target protein to develop flavonoid structure-based therapeutic agents.

  Yoshio Kusakabe; Shun-Suke Moriya; Toru Sugiyama; Yoshiki Miyata

  Bioorganic & medicinal chemistry 90 117362 - 117362 2023年07月
• Regulation of Endothelium-Reticulum-Stress-Mediated Apoptotic Cell Death by a Polymethoxylated Flavone, Nobiletin, Through the Inhibition of Nuclear Translocation of Glyceraldehyde 3-Phosphate Dehydrogenase in Retinal Müller Cells

  Yoshiki Miyata; Kazuya Matsumoto; Shuichi Kusano; Yoshio Kusakabe; Yoshiya Katsura; Tetsuta Oshitari; Hiroshi Kosano

  Cells 10 3 669 - 669 2021年03月
• Structure Activity Relationship Study of Polymethoxylated Flavones Targeted Retinal Müller Cells for Prevention of Retinal Diseases

  Yoshiki Miyata

  YAKUGAKU ZASSHI 141 1 41 - 45 2021年01月
• Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from <i>Kaempferia parviflora</i> for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells

  Yoshiki Miyata; Jin Tatsuzaki; Jinwei Yang; Hiroshi Kosano

  Biological and Pharmaceutical Bulletin 42 10 1658 - 1664 2019年10月
• In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line

  Yoshiki Miyata; Terumasa Nagase; Yoshiya Katsura; Hideyo Takahashi; Hideaki Natsugari; Tetsuta Oshitari; Hiroshi Kosano

  Biomedicine & Pharmacotherapy 93 70 - 80 2017年09月
• Cell-mediated contraction of vitreous explants from chicken embryo: possibility of screening for therapeutic agents against proliferative vitreoretinal diseases.

  Keitaro Oki; Yoshiki Miyata; Arata Shimada; Terumasa Nagase; Yoshiya Katsura; Hiroshi Kosano

  Molecular vision 19 2374 - 84 2013年
• Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells

  Yoshiki Miyata; Tetsuta Oshitari; Yuji Okuyama; Arata Shimada; Hideyo Takahashi; Hideaki Natsugari; Hiroshi Kosano

  Bioorganic & Medicinal Chemistry Letters 23 1 183 - 187 2013年01月
• Protein Kinase C-Mediated Regulation of Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase Production in a Human Retinal Müller Cells

  Yoshiki Miyata; Miho Kase; Yuko Sugita; Arata Shimada; Terumasa Nagase; Yoshiya Katsura; Hiroshi Kosano

  Current Eye Research 37 9 842 - 849 2012年06月
• B-Ring-modified and/or 5-demethylated nobiletin congeners: Inhibitory activity against pro-MMP-9 production

  Tetsuta Oshitari; Yuji Okuyama; Yoshiki Miyata; Hiroshi Kosano; Hideyo Takahashi; Hideaki Natsugari

  Bioorganic & Medicinal Chemistry 19 23 7085 - 7092 2011年12月
• Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production

  Tetsuta Oshitari; Yuji Okuyama; Yoshiki Miyata; Hiroshi Kosano; Hideyo Takahashi; Hideaki Natsugari

  Bioorganic & Medicinal Chemistry Letters 21 15 4540 - 4544 2011年08月
• Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin

  Yoshiki Miyata; Haruyuki Tanaka; Arata Shimada; Takashi Sato; Akira Ito; Toshikazu Yamanouchi; Hiroshi Kosano

  Life Sciences 88 13-14 613 - 618 2011年03月
• A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells

  Yoshiki Miyata; Takashi Sato; Keisuke Imada; Akira Dobashi; Masamichi Yano; Akira Ito

  Biochemical and Biophysical Research Communications 366 1 168 - 173 2008年02月
• Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells

  Yoshiki Miyata; Takashi Sato; Akira Ito

  Biochemical and Biophysical Research Communications 336 4 1081 - 1086 2005年11月
• Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.

  Yoshiki Miyata; Takashi Sato; Masamichi Yano; Akira Ito

  Molecular cancer therapeutics 3 7 839 - 47 2004年07月
• Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.

  Takashi Sato; Leona Koike; Yoshiki Miyata; Michiko Hirata; Yoshihiro Mimaki; Yutaka Sashida; Masamichi Yano; Akira Ito

  Cancer research 62 4 1025 - 9 2002年02月