Miyata Yoshiki

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Associate Professor
Graduate School of Pharmaceutical Sciences Associate Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202401009172589572

J-Global ID

• 202401009172589572

Research Areas

• Life sciences / Food sciences

Academic & Professional Experience

• 2018/04 - Today  Teikyo UniversityFaculty of Pharmaceutical Sciences
• 2013/04 - 2018/03  Teikyo UniversityFaculty of Pharmaceutical Sciences
• 2007/04 - 2013/03  Teikyo UniversityFaculty of Pharmaceutical Sciences
• 2006/04 - 2007/03  Teikyo UniversityFaculty of Pharmaceutical Sciences

Research Activity Information

Published Papers

• Synthesis of 23,23-Difluoro-24-nor- and 24′,24′-Difluoro-24-Homovitamin D3 Analogues and Unexpected Structure-Activity Relationships

  Fumihiro Kawagoe; Hiroya Tabuchi; Taiyo Ideguchi; Yuki Okamoto; Souma Murata; Tomofumi Yatsu; Syota Yamada; Kaori Yasuda; Yusuke Akagi; Masashi Takano; Toshie Fujishima; Yoshiki Miyata; Ken’ichi Aoki; Toshiyuki Sakaki; Atsushi Kittaka

  Organics MDPI AG 7 (2) 18 - 18 2026/04
• C22- to C26,27-Fluoro-2-(3-hydroxypropyl)-19-norvitamin D3, Side-chain Fluorinated MART-10s Suppress IL-19 Secretion from Th17-stimulated Keratinocytes: Potent Therapeutic Effects on Psoriasis Models

  Fumihiro Kawagoe; Sayuri Mototani; Mana Yamaguchi; Akiko Takeuchi; Tomofumi Yatsu; Kaori Yasuda; Masashi Takano; Yusuke Akagi; Toshie Fujishima; Yoshiki Miyata; Hiroshi Saitoh; Toshiyuki Sakaki; Atsushi Kittaka

  Synlett Georg Thieme Verlag KG 0936-5214 2026/04
• Comprehensive Synthesis of Side-Chain Fluorinated 2α-[2-(Tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3 Analogs and Preliminary Biological Activities.

  Fumihiro Kawagoe; Sayuri Mototani; Yuki Okamoto; Souma Murata; Akiko Takeuchi; Tomofumi Yatsu; Kaori Yasuda; Yusuke Akagi; Toshie Fujishima; Yoshiki Miyata; Hiroshi Saitoh; Toshiyuki Sakaki; Atsushi Kittaka

  Chemical & pharmaceutical bulletin 74 (1) 103 - 118 2026
• Reduction of Heterogeneous nuclear ribonucleoprotein A1 levels in retinal pigment epithelial cells induces inflammation and inhibits autophagy flux: pathology of age-related macular degeneration

  Tomofumi Yatsu; Ayaka Nagata; Takuya Chiba; Yoshiki Miyata

  Biochemistry and Biophysics Reports Elsevier BV 43 102195 - 102195 2405-5808 2025/09
• Changes in Protein Expression in Warmed Human Lens Epithelium Cells Using Shotgun Proteomics.

  Hiroko Otake; Tetsushi Yamamoto; Naoki Yamamoto; Yosuke Nakazawa; Yoshiki Miyata; Atsushi Taga; Hiroshi Sasaki; Noriaki Nagai

  Medicina (Kaunas, Lithuania) 61 (2) 2025/02
• VDR Is a Novel Regulator of Cellular Senescence in Lens Epithelial Cells.

  Tomofumi Yatsu; Momoka Koyama; Yoshiki Miyata

  Journal of nutritional science and vitaminology 71 (5) 395 - 401 2025
• Side-Chain Fluorine Engineering of Vitamin D3 Derivatives for VDR-Silent SREBP Inhibitors.

  Fumihiro Kawagoe; Sayuri Mototani; Tomofumi Yatsu; Yasushi Takemoto; Yusuke Akagi; Toshie Fujishima; Yoshiki Miyata; Motonari Uesugi; Atsushi Kittaka

  Chemical & pharmaceutical bulletin 73 (9) 868 - 883 2025
• Semiquantitative analysis of protein expression in heated rat lens using shotgun proteomics.

  Hiroko Otake; Shuya Masuda; Tetsushi Yamamoto; Yoshiki Miyata; Yosuke Nakazawa; Naoki Yamamoto; Atsushi Taga; Hiroshi Sasaki; Noriaki Nagai

  Molecular medicine reports 31 (1) 2025/01
• Dilation of porcine retinal arterioles to nobiletin, a polymethoxyflavonoid: Roles of nitric oxide and voltage-dependent potassium channel

  Masahisa Watanabe; Yoshiki Miyata; Akira Ohno; Harumasa Yokota; Koyo Takase; Junya Hanaguri; Akifumi Kushiyama; Satoru Yamagami; Seiyo Harino; Taiji Nagaoka

  Experimental Eye Research Elsevier BV 233 109548 - 109548 0014-4835 2023/08
• Isolation and identification of the new baicalin target protein to develop flavonoid structure-based therapeutic agents.

  Yoshio Kusakabe; Shun-Suke Moriya; Toru Sugiyama; Yoshiki Miyata

  Bioorganic & medicinal chemistry 90 117362 - 117362 2023/07
• Regulation of Endothelium-Reticulum-Stress-Mediated Apoptotic Cell Death by a Polymethoxylated Flavone, Nobiletin, Through the Inhibition of Nuclear Translocation of Glyceraldehyde 3-Phosphate Dehydrogenase in Retinal Müller Cells

  Yoshiki Miyata; Kazuya Matsumoto; Shuichi Kusano; Yoshio Kusakabe; Yoshiya Katsura; Tetsuta Oshitari; Hiroshi Kosano

  Cells MDPI AG 10 (3) 669 - 669 2021/03
• Structure Activity Relationship Study of Polymethoxylated Flavones Targeted Retinal Müller Cells for Prevention of Retinal Diseases

  Yoshiki Miyata

  YAKUGAKU ZASSHI Pharmaceutical Society of Japan 141 (1) 41 - 45 0031-6903 2021/01
• Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from <i>Kaempferia parviflora</i> for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells

  Yoshiki Miyata; Jin Tatsuzaki; Jinwei Yang; Hiroshi Kosano

  Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 42 (10) 1658 - 1664 0918-6158 2019/10
• In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line

  Yoshiki Miyata; Terumasa Nagase; Yoshiya Katsura; Hideyo Takahashi; Hideaki Natsugari; Tetsuta Oshitari; Hiroshi Kosano

  Biomedicine & Pharmacotherapy Elsevier BV 93 70 - 80 0753-3322 2017/09
• Cell-mediated contraction of vitreous explants from chicken embryo: possibility of screening for therapeutic agents against proliferative vitreoretinal diseases.

  Keitaro Oki; Yoshiki Miyata; Arata Shimada; Terumasa Nagase; Yoshiya Katsura; Hiroshi Kosano

  Molecular vision 19 2374 - 84 2013
• Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells

  Yoshiki Miyata; Tetsuta Oshitari; Yuji Okuyama; Arata Shimada; Hideyo Takahashi; Hideaki Natsugari; Hiroshi Kosano

  Bioorganic & Medicinal Chemistry Letters Elsevier BV 23 (1) 183 - 187 0960-894X 2013/01
• Protein Kinase C-Mediated Regulation of Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase Production in a Human Retinal Müller Cells

  Yoshiki Miyata; Miho Kase; Yuko Sugita; Arata Shimada; Terumasa Nagase; Yoshiya Katsura; Hiroshi Kosano

  Current Eye Research Informa UK Limited 37 (9) 842 - 849 0271-3683 2012/06
• B-Ring-modified and/or 5-demethylated nobiletin congeners: Inhibitory activity against pro-MMP-9 production

  Tetsuta Oshitari; Yuji Okuyama; Yoshiki Miyata; Hiroshi Kosano; Hideyo Takahashi; Hideaki Natsugari

  Bioorganic & Medicinal Chemistry Elsevier BV 19 (23) 7085 - 7092 0968-0896 2011/12
• Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production

  Tetsuta Oshitari; Yuji Okuyama; Yoshiki Miyata; Hiroshi Kosano; Hideyo Takahashi; Hideaki Natsugari

  Bioorganic & Medicinal Chemistry Letters Elsevier BV 21 (15) 4540 - 4544 0960-894X 2011/08
• Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin

  Yoshiki Miyata; Haruyuki Tanaka; Arata Shimada; Takashi Sato; Akira Ito; Toshikazu Yamanouchi; Hiroshi Kosano

  Life Sciences Elsevier BV 88 (13-14) 613 - 618 0024-3205 2011/03
• A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells

  Yoshiki Miyata; Takashi Sato; Keisuke Imada; Akira Dobashi; Masamichi Yano; Akira Ito

  Biochemical and Biophysical Research Communications Elsevier BV 366 (1) 168 - 173 0006-291X 2008/02
• Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells

  Yoshiki Miyata; Takashi Sato; Akira Ito

  Biochemical and Biophysical Research Communications Elsevier BV 336 (4) 1081 - 1086 0006-291X 2005/11
• Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.

  Yoshiki Miyata; Takashi Sato; Masamichi Yano; Akira Ito

  Molecular cancer therapeutics 3 (7) 839 - 47 1535-7163 2004/07
• Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.

  Takashi Sato; Leona Koike; Yoshiki Miyata; Michiko Hirata; Yoshihiro Mimaki; Yutaka Sashida; Masamichi Yano; Akira Ito

  Cancer research 62 (4) 1025 - 9 0008-5472 2002/02

Research Grants & Projects

• 眼移行性を志向したノビレチン点眼薬による糖尿病眼合併症の予防へ向けた応用研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2025/04 -2028/03 

  Author : 宮田 佳樹
• Synthetic study on polymethoxyflavones: separation and enhancing of their biological activities

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2015/04 -2018/03 

  Author : Oshitari Tetsuta; Miyata Yoshiki; Tabata Hidetsugu
• Prevention research for diabetic retinopathy based on structure-activity relationship study of novel polymethoxyflavones

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2013/04 -2015/03 

  Author : MIYATA Yoshiki; OSHITARI Tetsuta
• Synthesis and structure-activity relationships of polymethoxyflavones aimed at application to medical therapy of eye disease

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2015/03 

  Author : OSHITARI Tetsuta; KOSANO Hiroshi; MIYATA Yoshiki; TABATA Hidetsugu