Researchers Database

Miyata Yoshiki

Faculty of Pharmaceutical Sciences Associate Professor

Graduate School of Pharmaceutical Sciences Associate Professor

Last Updated :2025/06/28

Faculty of Pharmaceutical Sciences Associate Professor

Graduate School of Pharmaceutical Sciences Associate Professor

Changes in Protein Expression in Warmed Human Lens Epithelium Cells Using Shotgun Proteomics.
Hiroko Otake; Tetsushi Yamamoto; Naoki Yamamoto; Yosuke Nakazawa; Yoshiki Miyata; Atsushi Taga; Hiroshi Sasaki; Noriaki Nagai
Medicina (Kaunas, Lithuania) 61 (2) 2025/02

Semiquantitative analysis of protein expression in heated rat lens using shotgun proteomics.
Hiroko Otake; Shuya Masuda; Tetsushi Yamamoto; Yoshiki Miyata; Yosuke Nakazawa; Naoki Yamamoto; Atsushi Taga; Hiroshi Sasaki; Noriaki Nagai
Molecular medicine reports 31 (1) 2025/01

Dilation of porcine retinal arterioles to nobiletin, a polymethoxyflavonoid: Roles of nitric oxide and voltage-dependent potassium channel
Masahisa Watanabe; Yoshiki Miyata; Akira Ohno; Harumasa Yokota; Koyo Takase; Junya Hanaguri; Akifumi Kushiyama; Satoru Yamagami; Seiyo Harino; Taiji Nagaoka
Experimental Eye Research Elsevier BV 233 109548 - 109548 0014-4835 2023/08

Isolation and identification of the new baicalin target protein to develop flavonoid structure-based therapeutic agents.
Yoshio Kusakabe; Shun-Suke Moriya; Toru Sugiyama; Yoshiki Miyata
Bioorganic & medicinal chemistry 90 117362 - 117362 2023/07

Regulation of Endothelium-Reticulum-Stress-Mediated Apoptotic Cell Death by a Polymethoxylated Flavone, Nobiletin, Through the Inhibition of Nuclear Translocation of Glyceraldehyde 3-Phosphate Dehydrogenase in Retinal Müller Cells
Yoshiki Miyata; Kazuya Matsumoto; Shuichi Kusano; Yoshio Kusakabe; Yoshiya Katsura; Tetsuta Oshitari; Hiroshi Kosano
Cells MDPI AG 10 (3) 669 - 669 2021/03

Structure Activity Relationship Study of Polymethoxylated Flavones Targeted Retinal Müller Cells for Prevention of Retinal Diseases
Yoshiki Miyata
YAKUGAKU ZASSHI Pharmaceutical Society of Japan 141 (1) 41 - 45 0031-6903 2021/01

Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from <i>Kaempferia parviflora</i> for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells
Yoshiki Miyata; Jin Tatsuzaki; Jinwei Yang; Hiroshi Kosano
Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 42 (10) 1658 - 1664 0918-6158 2019/10

In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line
Yoshiki Miyata; Terumasa Nagase; Yoshiya Katsura; Hideyo Takahashi; Hideaki Natsugari; Tetsuta Oshitari; Hiroshi Kosano
Biomedicine & Pharmacotherapy Elsevier BV 93 70 - 80 0753-3322 2017/09

Cell-mediated contraction of vitreous explants from chicken embryo: possibility of screening for therapeutic agents against proliferative vitreoretinal diseases.
Keitaro Oki; Yoshiki Miyata; Arata Shimada; Terumasa Nagase; Yoshiya Katsura; Hiroshi Kosano
Molecular vision 19 2374 - 84 2013

Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells
Yoshiki Miyata; Tetsuta Oshitari; Yuji Okuyama; Arata Shimada; Hideyo Takahashi; Hideaki Natsugari; Hiroshi Kosano
Bioorganic & Medicinal Chemistry Letters Elsevier BV 23 (1) 183 - 187 0960-894X 2013/01

Protein Kinase C-Mediated Regulation of Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase Production in a Human Retinal Müller Cells
Yoshiki Miyata; Miho Kase; Yuko Sugita; Arata Shimada; Terumasa Nagase; Yoshiya Katsura; Hiroshi Kosano
Current Eye Research Informa UK Limited 37 (9) 842 - 849 0271-3683 2012/06

B-Ring-modified and/or 5-demethylated nobiletin congeners: Inhibitory activity against pro-MMP-9 production
Tetsuta Oshitari; Yuji Okuyama; Yoshiki Miyata; Hiroshi Kosano; Hideyo Takahashi; Hideaki Natsugari
Bioorganic & Medicinal Chemistry Elsevier BV 19 (23) 7085 - 7092 0968-0896 2011/12

Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production
Tetsuta Oshitari; Yuji Okuyama; Yoshiki Miyata; Hiroshi Kosano; Hideyo Takahashi; Hideaki Natsugari
Bioorganic & Medicinal Chemistry Letters Elsevier BV 21 (15) 4540 - 4544 0960-894X 2011/08

Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin
Yoshiki Miyata; Haruyuki Tanaka; Arata Shimada; Takashi Sato; Akira Ito; Toshikazu Yamanouchi; Hiroshi Kosano
Life Sciences Elsevier BV 88 (13-14) 613 - 618 0024-3205 2011/03

A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells
Yoshiki Miyata; Takashi Sato; Keisuke Imada; Akira Dobashi; Masamichi Yano; Akira Ito
Biochemical and Biophysical Research Communications Elsevier BV 366 (1) 168 - 173 0006-291X 2008/02

Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells
Yoshiki Miyata; Takashi Sato; Akira Ito
Biochemical and Biophysical Research Communications Elsevier BV 336 (4) 1081 - 1086 0006-291X 2005/11

Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.
Yoshiki Miyata; Takashi Sato; Masamichi Yano; Akira Ito
Molecular cancer therapeutics 3 (7) 839 - 47 1535-7163 2004/07

Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.
Takashi Sato; Leona Koike; Yoshiki Miyata; Michiko Hirata; Yoshihiro Mimaki; Yutaka Sashida; Masamichi Yano; Akira Ito
Cancer research 62 (4) 1025 - 9 0008-5472 2002/02