佐郡　和人 (サコオリ　カズト)

研究者情報

所属

• 薬学部 助教
• 大学院薬学研究科 助教

学位

• 博士（農学）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201501009743911770

J-Global ID

• 201501009743911770

研究キーワード

• 包括脳ネットワーク   薬物依存   ノシセプチン   自閉症   カンナビノイド   

研究分野

• ライフサイエンス / 神経科学一般

経歴

• 2023年04月 - 現在  帝京大学先端総合研究機構助教
• 2020年07月 - 2023年03月  東京大学医学部 神経生理学助教
• 2012年 - 2020年06月  東京大学医学部 神経生理学特任研究員
• 2009年 - 2011年  理化学研究所脳科学研究センター研究員
• 2009年 - 2009年  東京農工大学 博士号取得（論博）
• 2001年 - 2008年  理化学研究所脳科学研究センターテクニカルスタッフ

所属学協会

• 北米神経科学会   日本神経科学会   

研究活動情報

論文

• PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum

  Yuto Okuno; Kazuto Sakoori; Kyoko Matsuyama; Miwako Yamasaki; Masahiko Watanabe; Kouichi Hashimoto; Takaki Watanabe; Masanobu Kano

  Frontiers in Molecular Neuroscience 16 2023年06月
• Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics

  Misato Ichise; Kazuto Sakoori; Kei-ichi Katayama; Naoko Morimura; Kazuyuki Yamada; Hiroki Ozawa; Hayato Matsunaga; Minoru Hatayama; Jun Aruga

  FRONTIERS IN MOLECULAR NEUROSCIENCE 15 2022年05月 [査読有り]
  
• Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex

  Hiroaki Sacai; Kazuto Sakoori; Kohtarou Konno; Kenichiro Nagahama; Honoka Suzuki; Takaki Watanabe; Masahiko Watanabe; Naofumi Uesaka; Masanobu Kano

  Nature Communications 11 1 2020年12月 [査読有り]
  
• Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities.

  Kenichiro Nagahama; Kazuto Sakoori; Takaki Watanabe; Yusuke Kishi; Keita Kawaji; Michinori Koebis; Kazuki Nakao; Yukiko Gotoh; Atsu Aiba; Naofumi Uesaka; Masanobu Kano

  Cell reports 32 11 108126 - 108126 2020年09月 [査読有り]
  
• Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.

  Uesaka N; Abe M; Konno K; Yamazaki M; Sakoori K; Watanabe T; Kao TH; Mikuni T; Watanabe M; Sakimura K; Kano M

  Neuron 97 4 796 - 805.e5 2018年02月 [査読有り]
  
• Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.

  Nakazawa T; Hashimoto R; Sakoori K; Sugaya Y; Tanimura A; Hashimotodani Y; Ohi K; Yamamori H; Yasuda Y; Umeda-Yano S; Kiyama Y; Konno K; Inoue T; Yokoyama K; Inoue T; Numata S; Ohnuma T; Iwata N; Ozaki N; Hashimoto H; Watanabe M; Manabe T; Yamamoto T; Takeda M; Kano M

  Nature communications 7 11466  2016年04月 [査読有り]
  
• Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

  Takanobu Nakazawa; Ryota Hashimoto; Kazuto Sakoori; Yuki Sugaya; Asami Tanimura; Yuki Hashimotodani; Kazutaka Ohi; Hidenaga Yamamori; Yuka Yasuda; Satomi Umeda-Yano; Yuji Kiyama; Kohtarou Konno; Takeshi Inoue; Kazumasa Yokoyama; Takafumi Inoue; Shusuke Numata; Tohru Ohnuma; Nakao Iwata; Norio Ozaki; Hitoshi Hashimoto; Masahiko Watanabe; Toshiya Manabe; Tadashi Yamamoto; Masatoshi Takeda; Masanobu Kano

  NATURE COMMUNICATIONS 7 10594  2016年02月 [査読有り]
  
• Rines E3 Ubiquitin Ligase Regulates MAO-A Levels and Emotional Responses

  Miyuki Kabayama; Kazuto Sakoori; Kazuyuki Yamada; Veravej G. Ornthanalai; Maya Ota; Naoko Morimura; Kei-ichi Katayama; Niall P. Murphy; Jun Aruga

  JOURNAL OF NEUROSCIENCE 33 32 12940 - 12953 2013年08月 [査読有り]
  
• SLITRK6 mutations cause myopia and deafness in humans and mice

  Mustafa Tekin; Barry A. Chioza; Yoshifumi Matsumoto; Oscar Diaz-Horta; Harold E. Cross; Duygu Duman; Haris Kokotas; Heather L. Moore-Barton; Kazuto Sakoori; Maya Ota; Yuri S. Odaka; Joseph Foster; F. Basak Cengiz; Suna Tokgoz-Yilmaz; Oya Tekeli; Maria Grigoriadou; Michael B. Petersen; Ajith Sreekantan-Nair; Kay Gurtz; Xia-Juan Xia; Arti Pandya; Michael A. Patton; Juan I. Young; Jun Aruga; Andrew H. Crosby

  JOURNAL OF CLINICAL INVESTIGATION 123 5 2094 - 2102 2013年05月 [査読有り]
  
• Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia

  Noriko Takashima; Yuri S. Odaka; Kazuto Sakoori; Takumi Akagi; Tsutomu Hashikawa; Naoko Morimura; Kazuyuki Yamada; Jun Aruga

  PLOS ONE 6 7 e22716  2011年07月 [査読有り]
  
• Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients

  Minoru Hatayama; Akira Ishiguro; Yoshimi Iwayama; Noriko Takashima; Kazuto Sakoori; Tomoko Toyota; Yayoi Nozaki; Yuri S. Odaka; Kazuyuki Yamada; Takeo Yoshikawa; Jun Aruga

  SCIENTIFIC REPORTS 1 16  2011年06月 [査読有り]
  
• Executive dysfunction in novel environment and altered hippocampal synapse morphology in mice lacking Lrrtm1

  Takashima Noriko; Odaka Yuri; Sakoori Kazuto; Akagi Takumi; Hashikawa Tsutomu; Morimura Naoko; Yamada Kazuyuki; Aruga Jun

  Neuroscience Research 71 E284  2011年 [査読有り]
  
• Reduced degeneration of dopaminergic terminals and accentuated astrocyte activation by high dose methamphetamine administration in nociceptin receptor knock out mice

  Kazuto Sakoori; Niall P. Murphy

  NEUROSCIENCE LETTERS 469 3 309 - 313 2010年01月 [査読有り]
  
• Enhanced nicotine sensitivity in nociceptin/orphanin FQ receptor knockout mice

  Kazuto Sakoori; Niall P. Murphy

  NEUROPHARMACOLOGY 56 5 896 - 904 2009年04月 [査読有り]
  
• Expression of morphine-conditioned place preference is more vulnerable than naloxone-conditioned place aversion to disruption by nociceptin in mice

  Kazuto Sakoori; Niall P. Murphy

  NEUROSCIENCE LETTERS 443 2 108 - 112 2008年10月 [査読有り]
  
• Endogenous nociceptin (orphanin FQ) suppresses basal hedonic state and acute reward responses to methamphetamine and ethanol, but facilitates chronic responses

  Kazuto Sakoori; Niall P. Murphy

  NEUROPSYCHOPHARMACOLOGY 33 4 877 - 891 2008年03月 [査読有り]
  
• Lack of evidence of a role for the neurosteroid allopregnanolone in ethanol-induced reward and c-fos expression in DBA/2 mice

  Niall P. Murphy; Kazuto Sakoori; Chinami Okabe

  BRAIN RESEARCH 1094 1 107 - 118 2006年06月 [査読有り]
  
• Maintenance of conditioned place preferences and aversion in C57BL6 mice: effects of repeated and drug state testing

  K Sakoori; NP Murphy

  BEHAVIOURAL BRAIN RESEARCH 160 1 34 - 43 2005年05月 [査読有り]
  
• The NOP (ORL1) receptor antagonist Compound B stimulates mesolimbic dopamine release and is rewarding in mice by a non-NOP-receptor-mediated mechanism

  M Koizumi; K Sakoori; N Midorikawa; NP Murphy

  BRITISH JOURNAL OF PHARMACOLOGY 143 1 53 - 62 2004年09月 [査読有り]
  
• Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice

  K Sakoori; NP Murphy

  PSYCHOPHARMACOLOGY 172 2 129 - 136 2004年03月 [査読有り]
  

共同研究・競争的資金等の研究課題

• 内因性カンナビノイド2-AGが自閉スペクトラム症に及ぼす影響についての基礎的検討

  日本学術振興会：科学研究費助成事業

  研究期間 : 2022年04月 -2025年03月 

  代表者 : 佐郡 和人