口羽　文 (クチバ　アヤ)

研究者情報

所属

• 大学院公衆衛生学研究科 教授

学位

• 博士（保健学）（東京大学）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901019605395890

J-Global ID

• 200901019605395890

研究キーワード

• 生物統計学   疫学方法論   遺伝疫学   分子疫学   

研究分野

• 情報通信 / 統計科学
• ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない

経歴

• 2024年04月 - 現在  国立研究開発法人国立がん研究センターがん対策研究所 生物統計研究部 生物統計研究室室長（クロスアポイントメント）
• 2024年04月 - 現在  帝京大学公衆衛生学研究科教授
• 2017年04月 - 現在  横浜市立大学大学院医学系研究科 臨床統計学客員准教授
• 2021年12月 - 2024年03月  国立研究開発法人国立がん研究センター研究支援センター 生物統計部 医学統計室室長 （クロスアポイントメント）
• 2021年04月 - 2024年03月  神奈川県立保健福祉大学ヘルスイノベーション研究科准教授
• 2016年02月 - 2021年03月  国立がん研究センター研究支援センター 生物統計部室長
• 2014年07月 - 2016年01月  国立がん研究センター研究支援センター 生物統計部研究員
• 2013年07月 - 2014年07月  国立がん研究センター生物統計部門研究員
• 2010年08月 - 2013年06月  ダナ・ファーバーがん研究所研究員
• 2008年04月 - 2010年07月  国立がん研究センター 研究所腫瘍ゲノム解析・情報研究部研究員

学歴

• 2003年04月 - 2008年03月   東京大学大学院   医学系研究科   健康科学・看護学専攻
• 1999年04月 - 2003年03月   東京大学   理科II類 医学部   健康科学・看護学科

研究活動情報

論文

• Physical activity and exercise behaviour of breast cancer survivors: nationwide cross-sectional survey.

  Yoichi Shimizu; Katsunori Tsuji; Tomomi Narisawa; Aya Kuchiba; Taichi Shimazu; Eisuke Ochi; Naomi Sakurai; Hiroji Iwata; Hirokazu Arai; Yutaka Matsuoka

  BMJ supportive & palliative care 2025年04月 [査読有り]
  
• Germline Pathogenic Variants and Clinical Outcomes in Asian Patients With Breast Cancer.

  Rui Kitadai; Shu Yazaki; Aya Kuchiba; Takashi Yamanaka; Sho Shiino; Chisako Yamauchi; Kenichi Harano; Motonobu Saito; Yosuke Hirotsu; Hisaki Aiba; Teruhiko Yoshida; Ryuji Hamamoto; Chikako Shimizu; Akihiko Shimomura; Yuki Kojima; Tatsunori Shimoi; Yukihide Momozawa; Kazuki Sudo; Masayuki Yoshida; Kuniko Sunami; Megumi Hori; Kota Katanoda; Yoko Shimada; Yuji Yamashita; Takahiro Kogawa; Takeshi Murata; Saori Fujiwara; Yohei Miyagi; Hiroshi Nakagomi; Kazunoshin Tachibana; Masao Omata; Tohru Ohtake; Akihiko Suto; Tatsuya Onishi; Yoichi Naito; Toshinari Yamashita; Kan Yonemori; Takashi Kohno; Kouya Shiraishi

  Cancer science 2025年02月
• A phase 3 study (PATHWAY) of palbociclib plus tamoxifen in patients with HR-positive/HER2-negative advanced breast cancer.

  Emi Noguchi; Takashi Yamanaka; Hirofumi Mukai; Naohito Yamamoto; Chi-Feng Chung; Yen-Shen Lu; Dwan-Ying Chang; Joohyuk Sohn; Gun Min Kim; Kyung-Hun Lee; Soo-Chin Lee; Tsutomu Iwasa; Hiroji Iwata; Kenichi Watanabe; Kyung Hae Jung; Yuko Tanabe; Seok Yun Kang; Hiroyuki Yasojima; Kenjiro Aogi; Eriko Tokunaga; Sung Hoon Sim; Yoon Sim Yap; Koji Matsumoto; Ling-Ming Tseng; Yoshiko Umeyama; Kazuki Sudo; Yuki Kojima; Tomomi Hata; Aya Kuchiba; Taro Shibata; Kenichi Nakamura; Yasuhiro Fujiwara; Kenji Tamura; Kan Yonemori

  NPJ breast cancer 10 1 76 - 76 2024年08月
• Trastuzumab Deruxtecan in Human Epidermal Growth Factor Receptor 2-Expressing Biliary Tract Cancer (HERB; NCCH1805): A Multicenter, Single-Arm, Phase II Trial.

  Akihiro Ohba; Chigusa Morizane; Yasuyuki Kawamoto; Yoshito Komatsu; Makoto Ueno; Satoshi Kobayashi; Masafumi Ikeda; Mitsuhito Sasaki; Junji Furuse; Naohiro Okano; Nobuyoshi Hiraoka; Hiroshi Yoshida; Aya Kuchiba; Ryo Sadachi; Kenichi Nakamura; Naoko Matsui; Yoshiaki Nakamura; Wataru Okamoto; Takayuki Yoshino; Takuji Okusaka

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology JCO2302010  2024年08月
• Awareness, information sources, and beliefs regarding palliative care in the general population in Japan: a nationwide cross-sectional survey (INFORM study 2023)

  Yu Uneno; Masanori Mori; Junko Saito; Aki Otsuki; Aya Kuchiba; Naomi Sakurai; Naoki Nakaya; Maiko Fujimori; Taichi Shimazu

  Japanese Journal of Clinical Oncology 2024年07月
• Height, body mass index, physical activity, and risk of colorectal cancer in relation to expression of insulin receptor: The Japan Public Health Center-based Prospective Study.

  Kenshiro Nishihara; Shiori Nakano; Taiki Yamaji; Atsushi Goto; Akihisa Hidaka; Taichi Shimazu; Aya Kuchiba; Masahiro Saito; Fumihito Kunishima; Ryouji Nakaza; Ikuma Kato; Norie Sawada; Manami Inoue; Shoichiro Tsugane; Motoki Iwasaki

  International journal of cancer 2024年07月
• Dietary vitamin D intake and risk of colorectal cancer according to vitamin D receptor expression in tumors and their surrounding stroma.

  Shiori Nakano; Taiki Yamaji; Akihisa Hidaka; Taichi Shimazu; Kouya Shiraishi; Aya Kuchiba; Masahiro Saito; Fumihito Kunishima; Ryouji Nakaza; Takashi Kohno; Norie Sawada; Manami Inoue; Shoichiro Tsugane; Motoki Iwasaki

  Journal of gastroenterology 2024年06月
• Importance of circulating leptin and adiponectin in the causal pathways between obesity and the development of colorectal cancer in Japanese men.

  Masataka Taguri; Aya Kuchiba; Taiki Yamaji; Norie Sawada; Atsushi Goto; Motoki Iwasaki; Shoichiro Tsugane

  Journal of epidemiology 2024年04月
• Patients' perceptions of patient-centered communication with healthcare providers and associated factors in Japan - The INFORM Study 2020.

  Masako Okamura; Maiko Fujimori; Aki Otsuki; Junko Saito; Akiko Yaguchi-Saito; Aya Kuchiba; Yosuke Uchitomi; Taichi Shimazu

  Patient education and counseling 122 108170 - 108170 2024年01月
• Associations of individual characteristics and socioeconomic status with heated tobacco product harmfulness perceptions in Japan: A nationwide cross-sectional study (INFORM Study 2020).

  Takumi Momosaka; Junko Saito; Aki Otsuki; Akiko Yaguchi-Saito; Maiko Fujimori; Aya Kuchiba; Kota Katanoda; Reo Takaku; Taichi Shimazu

  Journal of epidemiology 2024年01月
• 日本人のHPVの認知や知識の年齢、性別、社会経済状況による格差 INFORM Study 2020

  寺田 万莉奈; 島津 太一; 齋藤 順子; 小田原 幸; 大槻 曜生; 矢口 明子; 宮脇 梨奈; 口羽 文; 石川 ひろの; 藤森 麻衣子; Kreps Gary L.

  Journal of Epidemiology 34 Suppl. 140 - 140 (一社)日本疫学会 2024年01月
• Trust in Mass Media as Sources of Cancer Information: Findings from a Nationally Representative Cross-Sectional Survey in Japan.

  Rina Miyawaki; Koichiro Oka; AKi Otsuki; Junko Saito; Akiko Yaguchi-Saito; Aya Kuchiba; Maiko Fujimori; Gary L Kreps; Taichi Shimazu

  Journal of health communication 1 - 12 2023年12月
• Age, gender and socioeconomic disparities in human papillomavirus (HPV) awareness and knowledge among Japanese adults after a 7-year suspension of proactive recommendation for the HPV vaccine: A nationally representative cross-sectional survey.

  Marina Terada; Taichi Shimazu; Junko Saito; Miyuki Odawara; Aki Otsuki; Akiko Yaguchi-Saito; Rina Miyawaki; Aya Kuchiba; Hirono Ishikawa; Maiko Fujimori; Gary L Kreps

  Vaccine 2023年10月
• Hypothesis testing procedure for binary and multi-class F1 -scores in the paired design.

  Kanae Takahashi; Kouji Yamamoto; Aya Kuchiba; Ayumi Shintani; Tatsuki Koyama

  Statistics in medicine 42 23 4177 - 4192 2023年10月
• Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study

  Shiori Nakano; Taiki Yamaji; Kouya Shiraishi; Akihisa Hidaka; Taichi Shimazu; Aya Kuchiba; Masahiro Saito; Fumihito Kunishima; Ryouji Nakaza; Takashi Kohno; Norie Sawada; Manami Inoue; Shoichiro Tsugane; Motoki Iwasaki

  Carcinogenesis 2023年08月 [査読有り]
  
• Interactive assistance via eHealth for small- and medium-sized enterprises' employer and health care manager teams on tobacco control (eSMART-TC): protocol for a cluster randomized hybrid type II trial (N-EQUITY2101/J-SUPPORT2102).

  Junko Saito; Miyuki Odawara; Maiko Fujimori; Aya Kuchiba; Shunsuke Oyamada; Khin Thet Swe; Eiko Saito; Kota Fukai; Masayuki Tatemichi; Masakazu Nakamura; Yosuke Uchitomi; Taichi Shimazu

  Implementation science communications 4 1 61 - 61 2023年06月
• Effect modification by geographic area on the association between health literacy and self-rated health: a nationwide cross-sectional study in Japan.

  Hirono Ishikawa; Runa Ogawa; Aki Otsuki; Junko Saito; Akiko Yaguchi-Saito; Aya Kuchiba; Maiko Fujimori; Yoshiharu Fukuda; Taichi Shimazu

  BMC public health 23 1 952 - 952 2023年05月 [査読有り]
  
• Genomic landscape and its prognostic significance in stage III colorectal cancer: JCOG1506A1, an ancillary of JCOG0910.

  Dai Shida; Aya Kuchiba; Tatsuhiro Shibata; Tetsuya Hamaguchi; Satoshi Yamasaki; Masaaki Ito; Takaya Kobatake; Toru Tonooka; Tadahiko Masaki; Manabu Shiozawa; Yasumasa Takii; Hiroyuki Uetake; Shu Okamura; Hitoshi Ojima; Shinsuke Kazama; Hiroshi Takeyama; Keisuke Kanato; Yasuhiro Shimada; Yoshinori Murakami; Yukihide Kanemitsu

  Cancer science 114 8 3352 - 3363 2023年05月
• Clinical trial design and analysis for comparing three treatments with intra-individual right- and left-hand data.

  Ryunosuke Machida; Kentaro Sakamaki; Aya Kuchiba

  Clinical trials (London, England) 17407745221150281 - 17407745221150281 2023年01月
• Lack of Significant Associations between Single Nucleotide Polymorphisms in LPAL2-LPA Genetic Region and Cancer Incidence and Mortality in Japanese Population: The Japan Public Health Center-Based Prospective Study

  Makiko Naka Mieno; Maria Yamasaki; Aya Kuchiba; Taiki Yamaji; Keigo Ide; Noriko Tanaka; Norie Sawada; Manami Inoue; Shoichiro Tsugane; Motoji Sawabe; Motoki Iwasaki

  SSRN Electronic Journal 2023年
• Family cancer history and smoking habit associated with sarcoma in a Japanese population study.

  Yoshihiro Araki; Norio Yamamoto; Yoshikazu Tanzawa; Takahiro Higashi; Aya Kuchiba; Katsuhiro Hayashi; Akihiko Takeuchi; Shinji Miwa; Kentaro Igarashi; Makoto Endo; Eisuke Kobayashi; Hiroyuki Tsuchiya; Akira Kawai

  Scientific reports 12 1 17129 - 17129 2022年10月
• 再発膠芽腫に対するエリブリンの第2相多施設単群医師主導治験

  高橋 雅道; 川嶋 聡; 口羽 文; 佐立 崚; 米盛 勧; 永根 基雄; 荒川 芳輝; 武笠 晃丈; 田中 將太; 西川 亮; 村垣 善浩; 増富 健吉; 市村 幸一; 中村 健一; 成田 善孝

  日本癌治療学会学術集会抄録集 60回 EN6 - 3 2022年10月
• Robust automated prediction of the revised Vienna Classification in colonoscopy using deep learning: development and initial external validation.

  Masayoshi Yamada; Ryosaku Shino; Hiroko Kondo; Shigemi Yamada; Hiroyuki Takamaru; Taku Sakamoto; Pradeep Bhandari; Hitoshi Imaoka; Aya Kuchiba; Taro Shibata; Yutaka Saito; Ryuji Hamamoto

  Journal of gastroenterology 2022年08月
• A phase II, multicenter, single-arm trial of eribulin in patients with bevacizumab-resistant recurrent glioblastoma.

  Masamichi Takahashi; Satoshi Kawashima; Yohei Otake; Natsuko Satomi-Tsushita; Aya Kuchiba; Ryo Sadachi; Keiko Ohata; Hitoshi Ozawa; Kan Yonemori; Motoo Nagane; Yoshiki Arakawa; Akitake Mukasa; Shota Tanaka; Ryo Nishikawa; Yoshihiro Muragaki; Kenkichi Masutomi; Koichi Ichimura; Kenichi Nakamura; Yoshitaka Narita

  Journal of Clinical Oncology 40 16_suppl 2036 - 2036 2022年06月
• Multicenter phase II trial of trastuzumab deruxtecan for HER2-positive unresectable or recurrent biliary tract cancer: HERB trial.

  Akihiro Ohba; Chigusa Morizane; Makoto Ueno; Satoshi Kobayashi; Yasuyuki Kawamoto; Yoshito Komatsu; Masafumi Ikeda; Mitsuhito Sasaki; Naohiro Okano; Junji Furuse; Nobuyoshi Hiraoka; Hiroshi Yoshida; Aya Kuchiba; Ryo Sadachi; Kenichi Nakamura; Naoko Matsui; Yoshiaki Nakamura; Wataru Okamoto; Takayuki Yoshino; Takuji Okusaka

  Future oncology (London, England) 18 19 2351 - 2360 2022年05月
• Confidence interval for micro-averaged F 1 and macro-averaged F 1 scores.

  Kanae Takahashi; Kouji Yamamoto; Aya Kuchiba; Tatsuki Koyama

  Applied intelligence (Dordrecht, Netherlands) 52 5 4961 - 4972 2022年03月 [査読有り]
  
• Accuracy of exercise-based tests for estimating cardiorespiratory fitness and muscle strength in early-stage breast cancer survivors in Japan.

  Katsunori Tsuji; Yutaka J Matsuoka; Aya Kuchiba; Akihiko Suto; Eisuke Ochi

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2022年01月
• A prognostic biomarker study in patients with clinical stage I esophageal squamous cell carcinoma: JCOG0502‐A1

  Kotoe Oshima; Ken Kato; Yoshinori Ito; Hiroyuki Daiko; Isao Nozaki; Satoru Nakagawa; Yuichi Shibuya; Takashi Kojima; Yasushi Toh; Morihito Okada; Shuichi Hironaka; Yuji Akiyama; Yoshito Komatsu; Kazuhiro Maejima; Hidewaki Nakagawa; Ritsuko Onuki; Momoko Nagai; Mamoru Kato; Keisuke Kanato; Aya Kuchiba; Kenichi Nakamura; Yuko Kitagawa

  Cancer Science 113 3 1018 - 1027 2021年12月
• Oncology care providers’ awareness and practice related to physical activity promotion for breast cancer survivors and barriers and facilitators to such promotion: a nationwide cross-sectional web-based survey

  Yoichi Shimizu; Katsunori Tsuji; Eisuke Ochi; Ryo Okubo; Aya Kuchiba; Taichi Shimazu; Noriatsu Tatematsu; Naomi Sakurai; Hiroji Iwata; Yutaka J. Matsuoka

  Supportive Care in Cancer 2021年12月
• Cardiorespiratory fitness in breast cancer survivors: a randomised controlled trial of home-based smartphone supported high intensity interval training.

  Eisuke Ochi; Katsunori Tsuji; Tomomi Narisawa; Yoichi Shimizu; Aya Kuchiba; Akihiko Suto; Kenjiro Jimbo; Shin Takayama; Taro Ueno; Naomi Sakurai; Yutaka Matsuoka

  BMJ supportive & palliative care 12 1 33 - 37 2021年08月
• TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma.

  Kenji Fujimoto; Hideyuki Arita; Kaishi Satomi; Kai Yamasaki; Yuko Matsushita; Taishi Nakamura; Yasuji Miyakita; Toru Umehara; Keiichi Kobayashi; Kaoru Tamura; Shota Tanaka; Fumi Higuchi; Yoshiko Okita; Yonehiro Kanemura; Junya Fukai; Daisuke Sakamoto; Takehiro Uda; Ryunosuke Machida; Aya Kuchiba; Taketoshi Maehara; Motoo Nagane; Ryo Nishikawa; Hiroyoshi Suzuki; Makoto Shibuya; Takashi Komori; Yoshitaka Narita; Koichi Ichimura

  Acta neuropathologica 142 2 323 - 338 2021年08月
• Effectiveness of a Cancer Risk Prediction Tool on Lifestyle Habits: A Randomized Controlled Trial.

  Keiichi Yuwaki; Aya Kuchiba; Aki Otsuki; Miyuki Odawara; Tsuyoshi Okuhara; Hirono Ishikawa; Manami Inoue; Shoichiro Tsugane; Taichi Shimazu

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 30 6 1063 - 1071 2021年03月
• Clinical Utility of Circulating Tumor DNA in Advanced Rare Cancers.

  Hitomi Sumiyoshi Okuma; Kan Yonemori; Yuki Kojima; Maki Tanioka; Kazuki Sudo; Emi Noguchi; Susumu Hijioka; Keiko Wakakuwa; Ken Kato; Akihiro Hirakawa; Aya Kuchiba; Takashi Kubo; Hitoshi Ichikawa; Akihiko Yoshida; Yasushi Yatabe; Kenichi Nakamura; Hiroyuki Mano; Noboru Yamamoto; Yasuhiro Fujiwara

  Frontiers in oncology 11 732525 - 732525 2021年
• TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations

  Hideyuki Arita; Yuko Matsushita; Ryunosuke Machida; Kai Yamasaki; Nobuhiro Hata; Makoto Ohno; Shigeru Yamaguchi; Takashi Sasayama; Shota Tanaka; Fumi Higuchi; Toshihiko Iuchi; Kuniaki Saito; Masayuki Kanamori; Ken-ichiro Matsuda; Yohei Miyake; Kaoru Tamura; Sho Tamai; Taishi Nakamura; Takehiro Uda; Yoshiko Okita; Junya Fukai; Daisuke Sakamoto; Yasuhiko Hattori; Eriel Sandika Pareira; Ryusuke Hatae; Yukitomo Ishi; Yasuji Miyakita; Kazuhiro Tanaka; Shunsaku Takayanagi; Ryohei Otani; Tsukasa Sakaida; Keiichi Kobayashi; Ryuta Saito; Kazuhiko Kurozumi; Tomoko Shofuda; Masahiro Nonaka; Hiroyoshi Suzuki; Makoto Shibuya; Takashi Komori; Hikaru Sasaki; Masahiro Mizoguchi; Haruhiko Kishima; Mitsutoshi Nakada; Yukihiko Sonoda; Teiji Tominaga; Motoo Nagane; Ryo Nishikawa; Yonehiro Kanemura; Aya Kuchiba; Yoshitaka Narita; Koichi Ichimura

  Acta Neuropathologica Communications 8 1 2020年12月
• Immunogenic characteristics of microsatellite instability-low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses.

  Yu Imamura; Tasuku Toihata; Ikumi Haraguchi; Yoko Ogata; Manabu Takamatsu; Aya Kuchiba; Norio Tanaka; Osamu Gotoh; Seiichi Mori; Yuichiro Nakashima; Eiji Oki; Masaki Mori; Yoshinao Oda; Kenichi Taguchi; Manabu Yamamoto; Masaru Morita; Naoya Yoshida; Hideo Baba; Shinji Mine; Souya Nunobe; Takeshi Sano; Tetsuo Noda; Masayuki Watanabe

  International journal of cancer 148 5 1260 - 1275 2020年09月
• Gastric cancer is highly prevalent in Lynch syndrome patients with atrophic gastritis.

  Hourin Cho; Masayoshi Yamada; Shigeki Sekine; Noriko Tanabe; Mineko Ushiama; Makoto Hirata; Gakuto Ogawa; Masahiro Gotoh; Teruhiko Yoshida; Takaki Yoshikawa; Yutaka Saito; Aya Kuchiba; Ichiro Oda; Kokichi Sugano

  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 24 2 283 - 291 2020年08月
• Phase II study of lenvatinib for metastatic colorectal cancer refractory to standard chemotherapy: the LEMON study (NCCH1503).

  Satoru Iwasa; Natsuko Okita; Aya Kuchiba; Gakuto Ogawa; Mamiko Kawasaki; Kenichi Nakamura; Hirokazu Shoji; Yoshitaka Honma; Atsuo Takashima; Ken Kato; Tetsuya Hamaguchi; Narikazu Boku; Yasuhide Yamada

  ESMO open 5 4 2020年08月
• Inclusion of a gene-environment interaction between alcohol consumption and the aldehyde dehydrogenase 2 genotype in a risk prediction model for upper aerodigestive tract cancer in Japanese men.

  Motoki Iwasaki; Sanjeev Budhathoki; Taiki Yamaji; Sachiko Tanaka-Mizuno; Aya Kuchiba; Norie Sawada; Atsushi Goto; Taichi Shimazu; Manami Inoue; Shoichiro Tsugane

  Cancer science 111 10 3835 - 3844 2020年07月
• How successful are we in relieving terminal dyspnea in cancer patients? A real-world multicenter prospective observational study.

  Masanori Mori; Tatsuya Morita; Yoshinobu Matsuda; Hirohide Yamada; Keisuke Kaneishi; Yoshihisa Matsumoto; Naoki Matsuo; Takuya Odagiri; Etsuko Aruga; Hiroaki Watanabe; Ryohei Tatara; Hiroki Sakurai; Akira Kimura; Hideki Katayama; Akihiko Suga; Tomohiro Nishi; Akemi Naito Shirado; Toshio Watanabe; Aya Kuchiba; Takuhiro Yamaguchi; Satoru Iwase

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 28 7 3051 - 3060 2020年07月 [査読有り]
  
• Lenvatinib in patients with advanced or metastatic thymic carcinoma (REMORA): a multicentre, phase 2 trial.

  Jun Sato; Miyako Satouchi; Shoichi Itoh; Yusuke Okuma; Seiji Niho; Hidenori Mizugaki; Haruyasu Murakami; Yasuhito Fujisaka; Toshiyuki Kozuki; Kenichi Nakamura; Yukari Nagasaka; Mamiko Kawasaki; Tomoaki Yamada; Ryunosuke Machida; Aya Kuchiba; Yuichiro Ohe; Noboru Yamamoto

  The Lancet. Oncology 21 6 843 - 850 2020年06月 [査読有り]
  
• Infection risk with PI3K-AKT-mTOR pathway inhibitors and immune checkpoint inhibitors in patients with advanced solid tumours in phase I clinical trials.

  Yutaka Fujiwara; Aya Kuchiba; Takafumi Koyama; Ryunosuke Machida; Akihiko Shimomura; Shigehisa Kitano; Toshio Shimizu; Noboru Yamamoto

  ESMO open 5 2 2020年04月
• Study protocol for a nationwide questionnaire survey of physical activity among breast cancer survivors in Japan.

  Yoichi Shimizu; Katsunori Tsuji; Eisuke Ochi; Hirokazu Arai; Ryo Okubo; Aya Kuchiba; Taichi Shimazu; Naomi Sakurai; Tomomi Narisawa; Taro Ueno; Hiroji Iwata; Yutaka Matsuoka

  BMJ open 10 1 e032871  2020年01月 [査読有り]
  
• Development of a real-time endoscopic image diagnosis support system using deep learning technology in colonoscopy

  Masayoshi Yamada; Yutaka Saito; Hitoshi Imaoka; Masahiro Saiko; Shigemi Yamada; Hiroko Kondo; Hiroyuki Takamaru; Taku Sakamoto; Jun Sese; Aya Kuchiba; Taro Shibata; Ryuji Hamamoto

  SCIENTIFIC REPORTS 9 1 14465  2019年10月 [査読有り]
  
• Impact of the Duration of Diabetes Mellitus on the Outcome of Metastatic Pancreatic Cancer Treated with Gemcitabine: A Retrospective Study.

  Sakura Iizumi; Aya Kuchiba; Takuji Okusaka; Masafumi Ikeda; Yasunari Sakamoto; Shunsuke Kondo; Chigusa Morizane; Hideki Ueno; Keiichiro Osame; Shuichi Mitsunaga; Izumi Ohno; Hiroshi Imaoka; Yusuke Hashimoto; Hideaki Takahashi; Mitsuhito Sasaki; Ken Ohashi

  Internal medicine (Tokyo, Japan) 58 17 2435 - 2441 2019年09月 [査読有り]
  
• Effect of home-based high-intensity interval training and behavioural modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: habit-B study protocol for a randomised controlled trial.

  Katsunori Tsuji; Eisuke Ochi; Ryo Okubo; Yoichi Shimizu; Aya Kuchiba; Taro Ueno; Taichi Shimazu; Takayuki Kinoshita; Naomi Sakurai; Yutaka Matsuoka

  BMJ open 9 8 e030911  2019年08月 [査読有り]
  
• Effect of home-based high-intensity interval training and behavioural modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: habit-B study protocol for a randomised controlled trial.

  Tsuji K; Ochi E; Okubo R; Shimizu Y; Kuchiba A; Ueno T; Shimazu T; Kinoshita T; Sakurai N; Matsuoka YJ

  BMJ Open 22 9 2019年08月 [査読有り]
  
• Single-arm, multicentre, phase II trial of nivolumab for unresectable or recurrent thymic carcinoma: PRIMER study.

  Katsuya Y; Horinouchi H; Seto T; Umemura S; Hosomi Y; Satouchi M; Nishio M; Kozuki T; Hida T; Sukigara T; Nakamura K; Kuchiba A; Ohe Y

  European journal of cancer (Oxford, England : 1990) 113 78 - 86 2019年05月 [査読有り]
  
• A phase II study of lenvatinib in patients with metastatic colorectal cancer refractory to standard chemotherapy: LEMON study (NCCH1503).

  Hirokazu Shoji; Satoru Iwasa; Aya Kuchiba; Gakuto Ogawa; Mamiko Kawasaki; Kenichi Nakamura; Mikio Mori; Yoshitaka Honma; Atsuo Takashima; Ken Kato; Narikazu Boku; Natsuko Okita; Yasuhide Yamada

  JOURNAL OF CLINICAL ONCOLOGY 37 15 2019年05月 [査読有り]
  
• Plasma C-peptide and glycated albumin and subsequent risk of cancer: From a large prospective case-cohort study in Japan.

  Akihisa Hidaka; Sanjeev Budhathoki; Taiki Yamaji; Norie Sawada; Sachiko Tanaka-Mizuno; Aya Kuchiba; Hadrien Charvat; Atsushi Goto; Taichi Shimazu; Manami Inoue; Mitsuhiko Noda; Shoichiro Tsugane; Motoki Iwasaki

  International journal of cancer 144 4 718 - 729 2019年02月 [査読有り]
  
• Exploring predictive biomarkers from clinical genome-wide association studies via multidimensional hierarchical mixture models.

  Otani T; Noma H; Sugasawa S; Kuchiba A; Goto A; Yamaji T; Kochi Y; Iwasaki M; Matsui S; Tsunoda T

  European journal of human genetics : EJHG 27 1 140 - 149 2018年09月 [査読有り]
  
• Association of anti-thyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab.

  Kimbara S; Fujiwara Y; Iwama S; Ohashi K; Kuchiba A; Arima H; Yamazaki N; Kitano S; Yamamoto N; Ohe Y

  Cancer science 2018年09月 [査読有り]
  
• Decomposition of the population attributable fraction for two exposures

  Masataka Taguri; Aya Kuchiba

  Annals of Epidemiology 28 5 331 - 334.e1 2018年05月 [査読有り]
  
• Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort.

  Sanjeev Budhathoki; Akihisa Hidaka; Taiki Yamaji; Norie Sawada; Sachiko Tanaka-Mizuno; Aya Kuchiba; Hadrien Charvat; Atsushi Goto; Satoshi Kojima; Natsuki Sudo; Taichi Shimazu; Shizuka Sasazuki; Manami Inoue; Shoichiro Tsugane; Motoki Iwasaki

  BMJ (Clinical research ed.) 360 k671  2018年03月 [査読有り]
  
• Tumor location is a risk factor for lymph node metastasis in superficial Barrett's adenocarcinoma.

  Yamada M; Oda I; Tanaka H; Abe S; Nonaka S; Suzuki H; Yoshinaga S; Kuchiba A; Koyanagi K; Igaki H; Taniguchi H; Sekine S; Saito Y; Tachimori Y

  Endoscopy international open 5 9 E868 - E874 2017年09月 [査読有り]
  
• Inclusion of a Genetic Risk Score into a Validated Risk Prediction Model for Colorectal Cancer in Japanese Men Improves Performance

  Motoki Iwasaki; Sachiko Tanaka-Mizuno; Aya Kuchiba; Taiki Yamaji; Norie Sawada; Atsushi Goto; Taichi Shimazu; Shizuka Sasazuki; Hansong Wang; Loic Le Marchand; Shoichiro Tsugane

  CANCER PREVENTION RESEARCH 10 9 535 - 541 2017年09月 [査読有り]
  
• A Prospective Study of Smoking and Risk of Synchronous Colorectal Cancers

  David A. Drew; Reiko Nishihara; Paul Lochhead; Aya Kuchiba; Zhi Rong Qian; Kosuke Mima; Katsuhiko Nosho; Kana Wu; Molin Wang; Edward Giovannucci; Charles S. Fuchs; Andrew T. Chan; Shuji Ogino

  AMERICAN JOURNAL OF GASTROENTEROLOGY 112 3 493 - 501 2017年03月 [査読有り]
  
• Accuracy of Death Certificates and Assessment of Factors for Misclassification of Underlying Cause of Death

  Makiko Naka Mieno; Noriko Tanaka; Tomio Arai; Takuya Kawahara; Aya Kuchiba; Shizukiyo Ishikawa; Motoji Sawabe

  JOURNAL OF EPIDEMIOLOGY 26 4 191 - 198 2016年04月 [査読有り]
  
• Statistical methods for studying disease subtype heterogeneity

  Molin Wang; Donna Spiegelman; Aya Kuchiba; Paul Lochhead; Sehee Kim; Andrew T. Chan; Elizabeth M. Poole; Rulla Tamimi; Shelley S. Tworoger; Edward Giovannucci; Bernard Rosner; Shuji Ogino

  STATISTICS IN MEDICINE 35 5 782 - 800 2016年02月 [査読有り]
  
• A novel method for evaluating antibody-dependent cell-mediated cytotoxicity by flowcytometry using cryopreserved human peripheral blood mononuclear cells

  Makiko Yamashita; Shigehisa Kitano; Hiroaki Aikawa; Aya Kuchiba; Mitsuhiro Hayashi; Noboru Yamamoto; Kenji Tamura; Akinobu Hamada

  SCIENTIFIC REPORTS 6 19772  2016年01月 [査読有り]
  
• 2015 Guidance on cancer immunotherapy development in early-phase clinical studies

  Teruyo Arato; Yoshiyuki Yamaguchi; Takashi Daimon; Yuji Heike; Ken Ishii; Kouji Kobiyama; Kyogo Itho; Shinichi Kageyama; Hiroshi Shiku; Yoshihiro Miyahara; Hiroaki Ikeda; Naozumi Harada; Daisuke Muraoka; Yutaka Kawakami; Eiichi Nakayama; Keiya Ozawa; Noriyuki Sato; Masahiro Takeuchi; Kenzaburo Tani; Koji Tamada; Ryuzo Ueda; Takeharu Yamanaka; Hiroki Yamaue; Masaki Yasukawa; Toyotaka Iguchi; Takeshi Terashima; Kohei Amakasu; Shigehisa Kitano; Yasuhiro Nagata; Masanori Noguchi; Takeo Asano; Motohiro Asonuma; Kazuhiro Kakimi; Kazutoh Takesako; Masanori Tanaka; Akira Yamada; Taiki Aoshi; Etsushi Kuroda; Naoya Yamazaki; Aya Kuchiba; Shiro Tanaka; Hirofumi Michimae; Tomomi Yamada; Kenichi Hanada; Hideho Okada; Naoko Takebe; Naoto Hirano; Satoshi Okumura; Masayoshi Shibatsuji; Daisaku Sato; Teruhide Yamaguchi

  Cancer Science 106 12 1761 - 1771 2015年12月 [査読有り]
  
• A Meta-Regression Method for Studying Etiological Heterogeneity Across Disease Subtypes Classified by Multiple Biomarkers

  Molin Wang; Aya Kuchiba; Shuji Ogino

  AMERICAN JOURNAL OF EPIDEMIOLOGY 182 3 263 - 270 2015年08月 [査読有り]
  
• Investigating endoscopic features of sessile serrated adenomas/polyps by using narrow-band imaging with optical magnification

  Masayoshi Yamada; Taku Sakamoto; Yosuke Otake; Takeshi Nakajima; Aya Kuchiba; Hirokazu Taniguchi; Shigeki Sekine; Ryoji Kushima; Hemchand Ramberan; Adolfo Parra-Blanco; Takahiro Fujii; Takahisa Matsuda; Yutaka Saito

  GASTROINTESTINAL ENDOSCOPY 82 1 108 - 117 2015年07月 [査読有り]
  
• SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological, and Molecular Features

  Tingting Li; Xiaoyun Liao; Paul Lochhead; Teppei Morikawa; Mai Yamauchi; Reiko Nishihara; Kentaro Inamura; Sun A. Kim; Kosuke Mima; Yasutaka Sukawa; Aya Kuchiba; Yu Imamura; Yoshifumi Baba; Kaori Shima; Jeffrey A. Meyerhardt; Andrew T. Chan; Charles S. Fuchs; Shuji Ogino; Zhi Rong Qian

  ANNALS OF SURGICAL ONCOLOGY 21 13 4164 - 4173 2014年12月 [査読有り]
  
• Tumor LINE-1 Methylation Level and Microsatellite Instability in Relation to Colorectal Cancer Prognosis

  Kentaro Inamura; Mai Yamauchi; Reiko Nishihara; Paul Lochhead; Zhi Rong Qian; Aya Kuchiba; Sun A. Kim; Kosuke Mima; Yasutaka Sukawa; Seungyoun Jung; Xuehong Zhang; Kana Wu; Eunyoung Cho; Andrew T. Chan; Jeffrey A. Meyerhardt; Curtis C. Harris; Charles S. Fuchs; Shuji Ogino

  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 106 9 2014年09月 [査読有り]
  
• Global methylation levels in peripheral blood leukocyte DNA by LUMA and breast cancer: a case-control study in Japanese women

  A. Kuchiba; M. Iwasaki; H. Ono; Y. Kasuga; S. Yokoyama; H. Onuma; H. Nishimura; R. Kusama; S. Tsugane; T. Yoshida

  BRITISH JOURNAL OF CANCER 110 11 2765 - 2771 2014年05月 [査読有り]
  
• Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

  Yu Imamura; Paul Lochhead; Mai Yamauchi; Aya Kuchiba; Zhi Rong Qian; Xiaoyun Liao; Reiko Nishihara; Seungyoun Jung; Kana Wu; Katsuhiko Nosho; Yaoyu E. Wang; Shouyong Peng; Adam J. Bass; Kevin M. Haigis; Jeffrey A. Meyerhardt; Andrew T. Chan; Charles S. Fuchs; Shuji Ogino

  MOLECULAR CANCER 13 135  2014年05月 [査読有り]
  
• Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase (HPGD)

  Stephen P. Fink; Mai Yamauchi; Reiko Nishihara; Seungyoun Jung; Aya Kuchiba; Kana Wu; Eunyoung Cho; Edward Giovannucci; Charles S. Fuchs; Shuji Ogino; Sanford D. Markowitz; Andrew T. Chan

  SCIENCE TRANSLATIONAL MEDICINE 6 233 233re2  2014年04月 [査読有り]
  
• 分子疫学研究における統計的方法論の展開：がんサブタイプへの取り組み

  口羽 文

  統計数理 62 1 123 - 133 統計数理研究所 2014年 [査読有り]
  
• Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations

  Hongmei Nan; Teppei Morikawa; Miia Suuriniemi; Yu Imamura; Lillian Werner; Aya Kuchiba; Mai Yamauchi; David J. Hunter; Peter Kraft; Edward L. Giovannucci; Charles S. Fuchs; Shuji Ogino; Matthew L. Freedman; Andrew T. Chan

  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105 24 1852 - 1861 2013年12月 [査読有り]
  
• Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy

  Reiko Nishihara; Kana Wu; Paul Lochhead; Teppei Morikawa; Xiaoyun Liao; Zhi Rong Qian; Kentaro Inamura; Sun A. Kim; Aya Kuchiba; Mai Yamauchi; Yu Imamura; Walter C. Willett; Bernard A. Rosner; Charles S. Fuchs; Edward Giovannucci; Shuji Ogino; Andrew T. Chan

  NEW ENGLAND JOURNAL OF MEDICINE 369 12 1095 - 1105 2013年09月 [査読有り]
  
• Prognostic significance of MTOR pathway component expression in neuroendocrine tumors.

  Qian ZR; Ter-Minassian M; Chan JA; Imamura Y; Hooshmand SM; Kuchiba A; Morikawa T; Brais LK; Daskalova A; Heafield R; Lin X; Christiani DC; Fuchs CS; Ogino S; Kulke MH

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31 27 3418 - 3425 2013年09月 [査読有り]
  
• Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication

  Paul Lochhead; Aya Kuchiba; Yu Imamura; Xiaoyun Liao; Mai Yamauchi; Reiko Nishihara; Zhi Rong Qian; Teppei Morikawa; Jeanne Shen; Jeffrey A. Meyerhardt; Charles S. Fuchs; Shuji Ogino

  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105 15 1151 - 1156 2013年08月 [査読有り]
  
• A Prospective Study of Duration of Smoking Cessation and Colorectal Cancer Risk by Epigenetics-related Tumor Classification

  Reiko Nishihara; Teppei Morikawa; Aya Kuchiba; Paul Lochhead; Mai Yamauchi; Xiaoyun Liao; Yu Imamura; Katsuhiko Nosho; Kaori Shima; Ichiro Kawachi; Zhi Rong Qian; Charles S. Fuchs; Andrew T. Chan; Edward Giovannucci; Shuji Ogino

  AMERICAN JOURNAL OF EPIDEMIOLOGY 178 1 84 - 100 2013年07月 [査読有り]
  
• Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status

  Reiko Nishihara; Paul Lochhead; Aya Kuchiba; Seungyoun Jung; Mai Yamauchi; Xiaoyun Liao; Yu Imamura; Zhi Rong Qian; Teppei Morikawa; Molin Wang; Donna Spiegelman; Eunyoung Cho; Edward Giovannucci; Charles S. Fuchs; Andrew T. Chan; Shuji Ogino

  JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 309 24 2563 - 2571 2013年06月 [査読有り]
  
• Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer

  Mai Yamauchi; Paul Lochhead; Yu Imamura; Aya Kuchiba; Xiaoyun Liao; Zhi Rong Qian; Reiko Nishihara; Teppei Morikawa; Kaori Shima; Kana Wu; Edward Giovannucci; Jeffrey A. Meyerhardt; Charles S. Fuchs; Andrew T. Chan; Shuji Ogino

  Cancer Epidemiology Biomarkers and Prevention 22 6 1142 - 1152 2013年06月 [査読有り]
  
• Expression of MTOR Pathway Components and Association With Clinical Outcomes in Neuroendocrine Tumors

  Qian Zhi Rong; Ter-Minassian Monica; Chan Jennifer A; Imamura Yu; Hooshm; Susanne M; Kuchiba Aya; Morikawa Teppei; Brais Lauren K; Daskalova Anastassia; Heafield Rachel; Lin Xihong; Christiani David C; Fuchs Charles S; Ogino Shuji; Kulke Matthew H

  PANCREAS 42 2 379  2013年03月 [査読有り]
  
• Prospective analysis of body mass index, physical activity, and colorectal cancer risk associated with β-catenin (CTNNB1) status.

  Morikawa T; Kuchiba A; Lochhead P; Nishihara R; Yamauchi M; Imamura Y; Liao X; Qian ZR; Ng K; Chan AT; Meyerhardt JA; Giovannucci E; Fuchs CS; Ogino S

  Cancer research 73 5 1600 - 1610 2013年03月 [査読有り]
  
• Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival

  Xabier Garcia-Albeniz; Hongmei Nan; Linda Valeri; Teppei Morikawa; Aya Kuchiba; Amanda I. Phipps; Carolyn M. Hutter; Ulrike Peters; Polly A. Newcomb; Charles S. Fuchs; Edward L. Giovannucci; Shuji Ogino; Andrew T. Chan

  CARCINOGENESIS 34 2 292 - 298 2013年02月 [査読有り]
  
• Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level.

  Ogino S; Nishihara R; Lochhead P; Imamura Y; Kuchiba A; Morikawa T; Yamauchi M; Liao X; Qian ZR; Sun R; Sato K; Kirkner GJ; Wang M; Spiegelman D; Meyerhardt JA; Schernhammer ES; Chan AT; Giovannucci E; Fuchs CS

  Journal of the National Cancer Institute 105 2 130 - 140 2013年01月 [査読有り]
  
• Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer

  Paul Lochhead; Yu Imamura; Teppei Morikawa; Aya Kuchiba; Mai Yamauchi; Xiaoyun Liao; Zhi Rong Qian; Reiko Nishihara; Kana Wu; Jeffrey A. Meyerhardt; Charles S. Fuchs; Shuji Ogino

  EUROPEAN JOURNAL OF CANCER 48 18 3405 - 3413 2012年12月 [査読有り]
  
• Association of dietary and genetic factors related to one-carbon metabolism with global methylation level of leukocyte DNA

  Hiroe Ono; Motoki Iwasaki; Aya Kuchiba; Yoshio Kasuga; Shiro Yokoyama; Hiroshi Onuma; Hideki Nishimura; Ritsu Kusama; Sumiko Ohnami; Hiromi Sakamoto; Teruhiko Yoshida; Shoichiro Tsugane

  CANCER SCIENCE 103 12 2159 - 2164 2012年12月 [査読有り]
  
• Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival

  Xiaoyun Liao; Paul Lochhead; Reiko Nishihara; Teppei Morikawa; Aya Kuchiba; Mai Yamauchi; Yu Imamura; Zhi Rong Qian; Yoshifumi Baba; Kaori Shima; Ruifang Sun; Katsuhiko Nosho; Jeffrey A. Meyerhardt; Edward Giovannucci; Charles S. Fuchs; Andrew T. Chan; Shuji Ogino

  NEW ENGLAND JOURNAL OF MEDICINE 367 17 1596 - 1606 2012年10月 [査読有り]
  
• Tumor TP53 expression status, body mass index and prognosis in colorectal cancer

  Teppei Morikawa; Aya Kuchiba; Xiaoyun Liao; Yu Imamura; Mai Yamauchi; Zhi Rong Qian; Reiko Nishihara; Kaori Sato; Jeffrey A. Meyerhardt; Charles S. Fuchs; Shuji Ogino

  INTERNATIONAL JOURNAL OF CANCER 131 5 1169 - 1178 2012年09月 [査読有り]
  
• Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers

  Yu Imamura; Teppei Morikawa; Xiaoyun Liao; Paul Lochhead; Aya Kuchiba; Mai Yamauchi; Zhi Rong Qian; Reiko Nishihara; Jeffrey A. Meyerhardt; Kevin M. Haigis; Charles S. Fuchs; Shuji Ogino

  CLINICAL CANCER RESEARCH 18 17 4753 - 4763 2012年09月 [査読有り]
  
• 消化器がん ゲノムワイド関連解析による膵癌発症関連遺伝子およびジェムシタビン副作用関連遺伝子の同定(Topics of gastrointestinal cancer Genome-wide association study of pancreatic cancer and hematological toxicities in patients receiving gemcitabine)

  前佛 均; 口羽 文; Low Siew-Kee; 清谷 一馬; 宇野 智子; 莚田 泰誠; 久保 充明; 平田 公一; 木村 康利; 山上 裕機; 吉田 輝彦; 坂本 裕美; 中村 祐輔

  日本癌学会総会記事 71回 229 - 229 2012年08月
• Predictors of Lymph Node Count in Colorectal Cancer Resections Data From US Nationwide Prospective Cohort Studies

  Teppei Morikawa; Noriko Tanaka; Aya Kuchiba; Katsuhiko Nosho; Mai Yamauchi; Jason L. Hornick; Richard S. Swanson; Andrew T. Chan; Jeffrey A. Meyerhardt; Curtis Huttenhower; Deborah Schrag; Charles S. Fuchs; Shuji Ogino

  ARCHIVES OF SURGERY 147 8 715 - 723 2012年08月 [査読有り]
  
• No Evidence for Interference of H&E Staining in DNA Testing Usefulness of DNA Extraction From H&E-Stained Archival Tissue Sections

  Teppei Morikawa; Kaori Shima; Aya Kuchiba; Mai Yamauchi; Noriko Tanaka; Yu Imamura; Xiaoyun Liao; Zhi Rong Qian; Mohan Brahmandam; Janina A. Longtine; Neal I. Lindeman; Charles S. Fuchs; Shuji Ogino

  AMERICAN JOURNAL OF CLINICAL PATHOLOGY 138 1 122 - 129 2012年07月 [査読有り]
  
• Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women

  Motoki Iwasaki; Hiroe Ono; Aya Kuchiba; Yoshio Kasuga; Shiro Yokoyama; Hiroshi Onuma; Hideki Nishimura; Ritsu Kusama; Teruhiko Yoshida; Shoichiro Tsugane

  BMC CANCER 12 323  2012年07月 [査読有り]
  
• Prognostic Significance and Molecular Associations of Tumor Growth Pattern in Colorectal Cancer

  Teppei Morikawa; Aya Kuchiba; Zhi Rong Qian; Mari Mino-Kenudson; Jason L. Hornick; Mai Yamauchi; Yu Imamura; Xiaoyun Liao; Reiko Nishihara; Jeffrey A. Meyerhardt; Charles S. Fuchs; Shuji Ogino

  ANNALS OF SURGICAL ONCOLOGY 19 6 1944 - 1953 2012年06月 [査読有り]
  
• Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum

  Mai Yamauchi; Teppei Morikawa; Aya Kuchiba; Yu Imamura; Zhi Rong Qian; Reiko Nishihara; Xiaoyun Liao; Levi Waldron; Yujin Hoshida; Curtis Huttenhower; Andrew T. Chan; Edward Giovannucci; Charles Fuchs; Shuji Ogino

  GUT 61 6 847 - 854 2012年06月 [査読有り]
  
• Postmenopausal Hormone Therapy Is Associated with a Reduced Risk of Colorectal Cancer Lacking CDKN1A Expression

  Jennifer H. Lin; Teppei Morikawa; Andrew T. Chan; Aya Kuchiba; Kaori Shima; Katsuhiko Nosho; Gregory Kirkner; Shumin M. Zhang; JoAnn E. Manson; Edward Giovannucci; Charles S. Fuchs; Shuji Ogino

  CANCER RESEARCH 72 12 3020 - 3028 2012年06月 [査読有り]
  
• Caffeine Increases Tear Volume Depending on Polymorphisms within the Adenosine A2a Receptor Gene and Cytochrome P450 1A2

  Reiko Arita; Yasuo Yanagi; Norihiko Honda; Shuji Maeda; Koshi Maeda; Aya Kuchiba; Takuhiro Yamaguchi; Yoshitsugu Yanagihara; Hiroshi Suzuki; Shiro Amano

  OPHTHALMOLOGY 119 5 972 - 978 2012年05月 [査読有り]
  
• Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review

  Xiaoyun Liao; Teppei Morikawa; Paul Lochhead; Yu Imamura; Aya Kuchiba; Mai Yamauchi; Katsuhiko Nosho; Zhi Rong Qian; Reiko Nishihara; Jeffrey A. Meyerhardt; Charles S. Fuchs; Shuji Ogino

  CLINICAL CANCER RESEARCH 18 8 2257 - 2268 2012年04月 [査読有り]
  
• Body Mass Index and Risk of Colorectal Cancer According to Fatty Acid Synthase Expression in the Nurses' Health Study

  Aya Kuchiba; Teppei Morikawa; Mai Yamauchi; Yu Imamura; Xiaoyun Liao; Andrew T. Chan; Jeffrey A. Meyerhardt; Edward Giovannucci; Charles S. Fuchs; Shuji Ogino

  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 104 5 415 - 420 2012年03月 [査読有り]
  
• TGFBR2 and BAX Mononucleotide Tract Mutations, Microsatellite Instability, and Prognosis in 1072 Colorectal Cancers

  Kaori Shima; Teppei Morikawa; Mai Yamauchi; Aya Kuchiba; Yu Imamura; Xiaoyun Liao; Jeffrey A. Meyerhardt; Charles S. Fuchs; Shuji Ogino

  PLOS ONE 6 9 e25062  2011年09月 [査読有り]
  
• Contribution of the TP53, OGG1, CHRNA3, and HLA-DQA1 Genes to the Risk for Lung Squamous Cell Carcinoma

  Takashi Kohno; Hideo Kunitoh; Sachiyo Mimaki; Kouya Shiraishi; Aya Kuchiba; Seiichiro Yamamoto; Jun Yokota

  JOURNAL OF THORACIC ONCOLOGY 6 4 813 - 817 2011年04月 [査読有り]
  
• Association of CTNNB1 (beta-Catenin) Alterations, Body Mass Index, and Physical Activity With Survival in Patients With Colorectal Cancer

  Teppei Morikawa; Aya Kuchiba; Mai Yamauchi; Jeffrey A. Meyerhardt; Kaori Shima; Katsuhiko Nosho; Andrew T. Chan; Edward Giovannucci; Charles S. Fuchs; Shuji Ogino

  JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 305 16 1685 - 1694 2011年04月 [査読有り]
  
• STAT3 Expression, Molecular Features, Inflammation Patterns, and Prognosis in a Database of 724 Colorectal Cancers

  Teppei Morikawa; Yoshifumi Baba; Mai Yamauchi; Aya Kuchiba; Katsuhiko Nosho; Kaori Shima; Noriko Tanaka; Curtis Huttenhower; David A. Frank; Charles S. Fuchs; Shuji Ogino

  CLINICAL CANCER RESEARCH 17 6 1452 - 1462 2011年03月 [査読有り]
  
• A Functional Single Nucleotide Polymorphism in Mucin 1, at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer

  Norihisa Saeki; Akira Saito; Il Ju Choi; Keitaro Matsuo; Sumiko Ohnami; Hirohiko Totsuka; Suenori Chiku; Aya Kuchiba; Yeon-Su Lee; Kyong-Ah Yoon; Myeong-Cherl Kook; Sook Ryun Park; Young-Woo Kim; Hideo Tanaka; Kazuo Tajima; Hiroshi Hirose; Fumihiko Tanioka; Yoshihiro Matsuno; Haruhiko Sugimura; Shunji Kato; Tsuneya Nakamura; Tomohiro Nishina; Wataru Yasui; Kazuhiko Aoyagi; Hiroki Sasaki; Kazuyoshi Yanagihara; Hitoshi Katai; Tadakazu Shimoda; Teruhiko Yoshida; Yusuke Nakamura; Setsuo Hirohashi; Hiromi Sakamoto

  GASTROENTEROLOGY 140 3 892 - 902 2011年03月 [査読有り]
  
• Mitochondrial Haplogroups A and M7a Confer a Genetic Risk for Coronary Atherosclerosis in the Japanese Elderly: An Autopsy Study of 1,536 Patients

  Motoji Sawabe; Masashi Tanaka; Kouji Chida; Tomio Arai; Yutaka Nishigaki; Noriyuki Fuku; Makiko Naka Mieno; Aya Kuchiba; Noriko Tanaka

  JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18 2 166 - 175 2011年 [査読有り]
  
• Association of DNA Repair Gene Polymorphisms With Response to Platinum-Based Doublet Chemotherapy in Patients With Non-Small-Cell Lung Cancer

  Kouya Shiraishi; Takashi Kohno; Chiharu Tanai; Yasushi Goto; Aya Kuchiba; Seiichiro Yamamoto; Koji Tsuta; Hiroshi Nokihara; Noboru Yamamoto; Ikuo Sekine; Yuichiro Ohe; Tomohide Tamura; Jun Yokota; Hideo Kunitoh

  JOURNAL OF CLINICAL ONCOLOGY 28 33 4945 - 4952 2010年11月 [査読有り]
  
• Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs

  Takashi Kohno; Ryutaro Kakinuma; Motoki Iwasaki; Taiki Yamaji; Hideo Kunitoh; Kenji Suzuki; Yoko Shimada; Kouya Shiraishi; Yoshio Kasuga; Gerson Shigeaki Hamada; Koh Furuta; Koji Tsuta; Hiromi Sakamoto; Aya Kuchiba; Seiichiro Yamamoto; Yae Kanai; Shoichiro Tsugane; Jun Yokota

  CARCINOGENESIS 31 10 1794 - 1799 2010年10月 [査読有り]
  
• 日本人集団に関する膵臓癌の全ゲノム連鎖解析(Genome-wide association study of pancreatic cancer in Japanese population)

  Low Siew-Kee; Kuchiba Aya; Zembutsu Hitoshi; Saito Akira; Takahashi Atsushi; Kubo Michiaki; Daigo Yataro; Kamatani Naoyuki; Okusaka Takuji; Yoshida Teruhiko; Nakamura Yusuke; Sakamoto Hiromi

  日本癌学会総会記事 69回 300 - 300 2010年08月
• Genome-Wide Association Study of Pancreatic Cancer in Japanese Population

  Siew-Kee Low; Aya Kuchiba; Hitoshi Zembutsu; Akira Saito; Atsushi Takahashi; Michiaki Kubo; Yataro Daigo; Naoyuki Kamatani; Suenori Chiku; Hirohiko Totsuka; Sumiko Ohnami; Hiroshi Hirose; Kazuaki Shimada; Takuji Okusaka; Teruhiko Yoshida; Yusuke Nakamura; Hiromi Sakamoto

  PLOS ONE 5 7 e11824  2010年07月 [査読有り]
  
• Long-term results of gastrectomy for alpha-fetoprotein-producing gastric cancer

  M. Inoue; T. Sano; A. Kuchiba; H. Taniguchi; T. Fukagawa; H. Katai

  BRITISH JOURNAL OF SURGERY 97 7 1056 - 1061 2010年07月 [査読有り]
  
• Genome-wide germline analyses on cancer susceptibility and GeMDBJ database: Gastric cancer as an example

  Teruhiko Yoshida; Hiroe Ono; Aya Kuchiba; Norihisa Saeki; Hiromi Sakamoto

  Cancer Science 101 7 1582 - 1589 2010年07月 [査読有り]
  
• Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes

  Takashi Kohno; Hideo Kunitoh; Yoko Shimada; Kouya Shiraishi; Yuko Ishii; Koichi Goto; Yuichiro Ohe; Yutaka Nishiwaki; Aya Kuchiba; Seiichiro Yamamoto; Hiroshi Hirose; Akira Oka; Noriko Yanagitani; Ryusei Saito; Hidetoshi Inoko; Jun Yokota

  CARCINOGENESIS 31 5 834 - 841 2010年05月 [査読有り]
  
• Smoking Confers a MTHFR 677C > T Genotype-Dependent Risk for Systemic Atherosclerosis: Results from a Large Number of Elderly Autopsy Cases that Died in a Community-Based General Geriatric Hospital

  Motoji Sawabe; Tomio Arai; Atsushi Araki; Takayuki Hosoi; Aya Kuchiba; Noriko Tanaka; Takahiro Naito; Kanae Oda; Shinobu Ikeda; Masaaki Muramatsu

  JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 16 2 91 - 104 2009年04月 [査読有り]
  
• Contact Lens Wear Is Associated with Decrease of Meibomian Glands

  Reiko Arita; Kouzo Itoh; Kenji Inoue; Aya Kuchiba; Takuhiro Yamaguchi; Shiro Amano

  OPHTHALMOLOGY 116 3 379 - 384 2009年03月 [査読有り]
  
• ゲノム網羅的SNP解析による疾患研究 : 遺伝統計学的課題

  口羽 文; 吉田 輝彦

  化学と生物 47 1 28 - 34 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2009年01月
• Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese

  Kouya Shiraishi; Takashi Kohno; Hideo Kunitoh; Shun-ichi Watanabe; Koichi Goto; Yutaka Nishiwaki; Yoko Shimada; Hiroshi Hirose; Ikuo Saito; Aya Kuchiba; Seiichro Yamamoto; Jun Yokota

  CARCINOGENESIS 30 1 65 - 70 2009年01月 [査読有り]
  
• Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias

  Takashi Kohno; Hideo Kunitoh; Kenji Suzuki; Seiichiro Yamamoto; Aya Kuchiba; Yoshihiro Matsuno; Noriko Yanagitani; Jun Yokota

  CARCINOGENESIS 29 5 957 - 963 2008年05月 [査読有り]
  
• Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases

  Kanae Oda; Noriko Tanaka; Tomio Arai; Jungo Araki; Yixuan Song; Ling Zhang; Aya Kuchiba; Takayuki Hosoi; Takuji Shirasawa; Masaaki Muramatsu; Motoji Sawabe

  HUMAN MOLECULAR GENETICS 16 6 592 - 599 2007年03月 [査読有り]
  
• Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk

  Takashi Kohno; Tokuki Sakiyama; Hideo Kunitoh; Koichi Goto; Yutaka Nishiwaki; Daizo Saito; Hiroshi Hirose; Takashi Eguchi; Noriko Yanagitani; Ryusei Saito; Rumie Sasaki-Matsumura; Sachiyo Mimaki; Kaoru Toyama; Seiichiro Yamamoto; Aya Kuchiba; Tomotaka Sobue; Tsutomu Ohta; Misao Ohki; Jun Yokota

  CARCINOGENESIS 27 12 2448 - 2454 2006年12月 [査読有り]
  
• Association of the OGG1-Ser326Cys polymorphism with lung adenocarcinoma risk

  T Kohno; H Kunitoh; K Toyama; S Yamamoto; A Kuchiba; D Saito; N Yanagitani; SI Ishihara; R Saito; J Yokota

  CANCER SCIENCE 97 8 724 - 728 2006年08月 [査読有り]
  
• Optimum two-stage designs in case-control association studies using false discovery rate

  Aya Kuchiba; Noriko Y. Tanaka; Yasuo Ohashi

  JOURNAL OF HUMAN GENETICS 51 12 1046 - 1054 2006年 [査読有り]
  

書籍

• Textbook of Clinical Trials in Oncology

  口羽 文 (担当:分担執筆範囲:Sample Size Calculations for Phase III Trials in Oncology)CRC Press 2019年
• Frontiers of Biostatistical Methods and Applications in Clinical Oncology

  口羽文 (担当:分担執筆範囲:Evaluation of Cancer Risk in Epidemiologic Studies with Genetic and Molecular Data)Springer Singapore 2017年
• 統計応用の百科事典

  松井茂之; 口羽文 (担当:分担執筆範囲:ゲノムデータ解析，ゲノムワイドスクリーニング，遺伝疫学)丸善出版 2011年

MISC

• 再発膠芽腫に対するエリブリンの第2相多施設単群医師主導治験

  高橋 雅道; 川嶋 聡; 口羽 文; 佐立 崚; 米盛 勧; 永根 基雄; 荒川 芳輝; 武笠 晃丈; 田中 將太; 西川 亮; 村垣 善浩; 増富 健吉; 市村 幸一; 中村 健一; 成田 善孝 日本癌治療学会学術集会抄録集 60回 EN6 -3 2022年10月
• Influential factors to implement cancer prevention measures at small and medium-sized enterprises: A qualitative study

  Junko Saito; Hirokazu Takahashi; Akiko Yaguchi; Maiko Fujimori; Aya Kuchiba; Eiko Saito; Manami Inoue; Yosuke Uchitomi; Taichi Shimazu CANCER SCIENCE 112 942 -942 2021年02月
• The genomic landscape and its prognostic significance for stage III colorectal cancer in Japan: An ancillary study of JCOG0910 trial-JCOG1506A1.

  Dai Shida; Aya Kuchiba; Tatsuhiro Shibata; Tetsuya Hamaguchi; Satoshi Yamasaki; Masaaki Ito; Takaya Kobatake; Nobuhiro Takiguchi; Tadahiko Masaki; Manabu Shiozawa; Yasumasa Takii; Hiroyuki Uetake; Shu Okamura; Hitoshi Ojima; Yusuke Nishizawa; Hiroshi Takeyama; Keisuke Kanato; Yasuhiro Shimada; Yoshinori Murakami; Yukihide Kanemitsu JOURNAL OF CLINICAL ONCOLOGY 37 (15) 2019年05月
• 切除不能または再発胸腺癌に対するレンバチニブの多施設共同第II相試験

  仁保誠治; 佐藤潤; 佐藤潤; 大熊裕介; 上月稔幸; 村上晴泰; 水柿秀紀; 藤阪保仁; 里内美弥子; 中村健一; 長坂優佳里; 川崎真実子; 山田知明; 町田龍之介; 口羽文; 山本昇; 山本昇 日本肺癌学会総会号 60th 2019年
• Development of a Real-time Endoscopic Image Diagnosis Support System Using Deep Learning Technology in Colonoscopy

  Masayoshi Yamada; Yutaka Saito; Shigemi Yamada; Hiroko Kondo; Aya Kuchiba; Ryuji Hamamoto CANCER SCIENCE 109 179 -179 2018年12月
• Impact of the duration of diabetes mellitus (DM) on the outcomes of metastatic pancreatic cancer (mPC) treated with gemcitabine (G): A retrospective study

  K. Ohashi; S. Iizumi; A. Kuchiba; M. Ikeda; Y. Sakamoto; S. Kondo; C. Morizane; H. Ueno; K. Osame; S. Mitsunaga; I. Ohno; H. Imaoka; Y. Hashimoto; H. Takahashi; M. Sasaki; T. Okusaka ANNALS OF ONCOLOGY 28 2017年09月
• A novel method for evaluating antibody-dependent cell-mediated cytotoxicity by flow cytometry using cryopreserved human peripheral blood mononuclear cells

  Shigehisa Kitano; Makiko Yamashita; Hiroaki Aikawa; Aya Kuchiba; Mitsuhiro Hayashi; Noboru Yamamoto; Kenji Tamura; Akinobu Hamada CANCER RESEARCH 76 2016年07月
• A prospective study of smoking habit and risk of synchronous colorectal cancers

  David A. Drew; Reiko Nishihara; Paul Lochhead; Aya Kuchiba; Zhi Rong Qian; Kosuke Mima; Katsuhiko Nosho; Kana Wu; Molin Wang; Donna Spiegelnnan; Edward L. Giovannucci; Charles S. Fuchs; Shuji Ogino; Andrew T. Chan CANCER RESEARCH 76 2016年07月
• Aspirin Use and the Risk of Colorectal Cancer Is Modified According to Colonic 15-Prostaglandin Dehydrogenase Expression

  Stephen P. Fink; Mai Yamauchi; Reiko Nishihara; Seungyoun Jung; Aya Kuchiba; Kana Wu; Eunyoung Cho; Edward Giovannucci; Charles Fuchs; Shuji Ogino; Sanford Markowitz; Andrew T. Chan GASTROENTEROLOGY 146 (5) S130 -S131 2014年05月
• NOVEL METHODOLOGIES TO ADDRESS MOLECULAR HETEROGENEITY OF DISEASE PROCESSES IN EPIDEMIOLOGIC RESEARCH.

  Aya Kuchiba; Molin Wang; Shuji Ogino; Donna Spiegelman AMERICAN JOURNAL OF EPIDEMIOLOGY 177 S121 -S121 2013年06月
• THE VALIDITY AND EFFICIENCY OF THE COMMON EFFECT TEST FOR SUBTYPE ANALYSIS IN CASE-CASE STUDIES.

  Molin Wang; Aya Kuchiba AMERICAN JOURNAL OF EPIDEMIOLOGY 177 S134 -S134 2013年06月
• Colon Cancer Nodal Staging Score: A Tool To Assess Adequacy of Nodal Harvesting in Pathology Practice

  A. Kuchiba; P. Lochhead; S. Ogino LABORATORY INVESTIGATION 93 161A -162A 2013年02月
• Colon Cancer Nodal Staging Score: A Tool To Assess Adequacy of Nodal Harvesting in Pathology Practice

  A. Kuchiba; P. Lochhead; S. Ogino MODERN PATHOLOGY 26 161A -162A 2013年02月
• Aspirin Use, the 8q24 Cancer Susceptibility SNP rs6983267, and Risk of Colorectal Cancer According to CTNNB1 (beta-Catenin) Alterations

  Hongmei Nan; Teppei Morikawa; Aya Kuchiba; Mai Yamauchi; Peter Kraft; Edward Giovannucci; Charles S. Fuchs; Matthew L. Freedman; Shuji Ogino; Andrew T. Chan GASTROENTEROLOGY 142 (5) S153 -S154 2012年05月
• 全ゲノム関連解析により同定されたびまん型胃がん易罹患性関連染色体領域1q22及びその機能的SNP(Genome-wide association study identified chromosome region 1q22 as a susceptibility locus of diffuse-type gastric)

  佐伯 宣久; 斎藤 聡; 松尾 恵太郎; 片井 均; 大浪 澄子; 口羽 文; 佐々木 博己; 椙村 春彦; 中村 祐輔; 廣橋 説雄; 吉田 輝彦; 坂本 裕美 日本癌学会総会記事 69回 257 -257 2010年08月
• Genome-wide germline analyses on cancer susceptibility and GeMDBJ database: Gastric cancer as an example

  Teruhiko Yoshida; Hiroe Ono; Aya Kuchiba; Norihisa Saeki; Hiromi Sakamoto CANCER SCIENCE 101 (7) 1582 -1589 2010年07月

共同研究・競争的資金等の研究課題

• 複雑な疫学データに対する多段階サンプリングモデルの応用

  日本学術振興会：科学研究費助成事業

  研究期間 : 2021年04月 -2024年03月 

  代表者 : 口羽 文; 坂巻 顕太郎; 篠崎 智大
• 大規模コホート研究に基づくビタミンDとがん罹患の因果関係評価に資する分子疫学研究

  日本学術振興会：科学研究費助成事業 基盤研究(B)

  研究期間 : 2020年04月 -2023年03月 

  代表者 : 岩崎 基; 口羽 文; 武藤 諒子
• 個人の発がんリスク評価方法の革新的改善に資する疫学研究の推進

  日本医療研究開発機構：日本医療研究開発機構研究費

  研究期間 : 2020年04月 -2023年03月
• 全国がん登録情報で得られる乳がん・卵巣がん・子宮体がんの発症率と胚細胞系列変異との統合解析による累積リスク評価系の構築

  厚生労働省：厚生労働科学研究費補助金(厚生科研費)

  研究期間 : 2020年04月 -2022年03月
• 個人のがんリスクに応じて開発された個別化予防のための累積リスク予測ツールの評価に関する介入研究

  日本医療研究開発機構：日本医療研究開発機構研究費

  研究期間 : 2017年 -2019年 

  代表者 : 島津太一
• 統合された科学的根拠に基づく日本人のためのがんリスク評価モデルの開発とその革新的改善に資する疫学研究の推進

  日本医療研究開発機構：日本医療研究開発機構研究費

  研究期間 : 2017年 -2019年 

  代表者 : 岩崎基
• がんと糖尿病：両者を繋ぐメカニズム、糖尿病併存がん患者の実態に関する包括的な疫学研究

  日本医療研究開発機構：日本医療研究開発機構研究費

  研究期間 : 2017年 -2019年 

  代表者 : 後藤温
• 予測モデル構築のための研究デザインと予測性能の評価方法

  日本学術振興会：科学研究費助成事業 若手研究(B)

  研究期間 : 2015年04月 -2018年03月 

  代表者 : 口羽 文
• ゲノム等のバイオマーカー情報に基づく希少がん・希少フラクション領域の臨床開発を促進するための基盤整備研究

  日本医療研究開発機構：日本医療研究開発機構研究費

  研究期間 : 2017年 -2017年 

  代表者 : 佐藤暁洋
• アンメットメディカルニーズにおける抗がん薬のPK/PDに基づく最適化医療の実施

  厚生労働科学研究費：革新的がん医療実用化研究事業

  研究期間 : 2014年 -2016年 

  代表者 : 濱田哲暢
• がん患者の重大症状に対する緩和治療開発に関する多施設共同臨床研究

  厚生労働科学研究費：革新的がん医療実用化研究事業

  研究期間 : 2014年 -2016年 

  代表者 : 岩瀬哲
• 前向き大規模コホート研究において既に収集されているがん罹患前試料・ 情報を用いた発がんリスク要因の探索と層別化に関する研究

  厚生労働科学研究費：革新的がん医療実用化研究事業

  研究期間 : 2014年 -2016年 

  代表者 : 岩崎基
• 血液検体のゲノム・エピゲノム・トランスクリプトーム解析に基づく、膵がん・肺がん等の高危険度群の捕捉のためのバイオマーカーの同定(23300301)

  厚生労働科学研究費：厚生労働科学研究費補助金

  研究期間 : 2011年 -2013年 

  代表者 : 吉田輝彦
• 生活習慣や支持療法等が乳がん患者のQOLに与える影響を調べる多目的コホート研究

  厚生労働科学研究費：厚生労働科学研究費補助金

  研究期間 : 2009年 -2009年 

  代表者 : 山本精一郎

委員歴

• 2024年11月 - 現在   厚生労働省 社会保障審議会医療保険部会 匿名医療情報等の提供に関する専門委員会   専門委員
• 2024年10月 - 現在   日本医療研究開発機構（AMED）   課題評価委員
• 2024年09月 - 現在   独立行政法人 医薬品医療機器総合機構（PMDA）   専門員
• 2024年04月 - 現在   国立がん研究センター   中央病院臨床研究審査委員会，技術専門員
• 2024年01月 - 現在   日本がん治療認定医機構   教育委員会委員
• 2023年03月 - 現在   日本計量生物学会   理事
• 2023年01月 - 現在   日本計量生物学会   評議員（社員）
• 2022年05月 - 現在   神奈川ME-BYO リビングラボ   専門委員（アドバイザー）
• 2021年10月 - 現在   Japanese Journal of Statistics and Data Science   Associate Editor
• 2020年11月 - 現在   Breast Cancer, Editorial Board   Statistical Consultants
• 2019年10月 - 現在   日本消化器内視鏡学会 和文誌編集委員会   外部委員
• 2018年04月 - 現在   国立がん研究センター東病院臨床研究審査委員会   技術専門員
• 2015年04月 - 現在   Japanese Journal of Clinical Oncology   Statistics Advisor
• 2010年 - 現在   Japanese Organization for Research and Treatment of Cancer (JORTC) プロトコール審査委員会/独立データモニタリング委員会   委員
• 2021年01月 - 2024年06月   BMC Cancer   Editorial Board Member
• 2023年05月 - 2024年03月   厚生労働省   創薬環境の変化に対応するための薬事審査等のあり方に関する検討会，構成員
• 2018年04月 - 2024年03月   国立がん研究センター中央病院臨床研究審査委員会   委員
• 2019年01月 - 2023年03月   計量生物学 編集委員会   委員