Yamori Takao

Researcher Information

Affiliation

Academic Research Center (TARC) Professor

Degree

• (BLANK)
• (BLANK)

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901001177717880

J-Global ID

• 200901001177717880

Research Interests

• 薬事   分子薬理学   腫瘍生物学   がん化学療法   Molecular Pharmacology   Tumor Biology   Cancer Chemotherapy   

Research Areas

• Informatics / Information theory / ﾚｷﾞｭﾗﾄﾘｰｻｲｴﾝｽ
• Life sciences / Tumor biology / 腫瘍学
• Life sciences / Pharmaceuticals - chemistry and drug development
• Life sciences / Pharmacology
• Life sciences / Pharmaceuticals - health and biochemistry
• Life sciences / Cell biology

Association Memberships

• THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER   日本臨床腫瘍学会   日本DDS学会   日本がん臨床試験推進機構   International Symposium on Cancer Chemotherapy   Metastasis Research Society   日本薬学会   日本生化学会   American Association for Cancer Research   日本癌学会   

Research Activity Information

Books etc

• がん細胞パネルによる創薬

  細胞工学 2013
• 特集・制がん剤の分子標的スクリーニング成績 化学療法基盤情報支援班報告-制がん候補物質のスクリーニング成績・第14報-

  癌と化学療法 2013
• 特集・制がん剤の分子標的スクリーニング成績 化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報-

  癌と化学療法 2013
• 産学連携による日本発の医薬品創出へ向けて

  臨床医薬 2013
• 膜小胞輸送にかかわるADPリボシル化因子1の新規阻害剤AMF-26によるゴルジ装置の破壊と抗がん作用

  生体の科学 2012
• PI3K-Akt-mTOR経路とその阻害剤

  がん分子標的治療 2012
• アカデミアの立場からの新薬開発支援 がん支援・化学療法基盤支援活動の取り組み

  腫瘍内科 2012
• JFCR39がん細胞パネルの活用による新たな抗がん剤創薬

  実験医学 2012
• PI3K/mTOR経路阻害薬（西尾和人編「がん分子標的薬治療の現状と展望」2541-2547/2750ページ）

  東京: ライフ・サイエンス 2011
• プロテインチップを利用した抗がん剤の作用因子解析（小田吉哉・長野光司編「創薬・タンパク質研究のためのプロテオミクス解析-バイオマーカー・標的探索、作用機序解析の研究戦略と実践マニュアル」175-181/227ページ）

  東京: 羊土社 2010
• PI3キナーゼを標的とした癌治療－PI3K阻害剤開発の現状（佐々木雄彦・横溝岳彦・竹縄忠臣編「分子から個体へと深化する脂質生物学」164-172/235ページ）

  東京: 羊土社 2010
• キナーゼ阻害薬

  日本臨牀 2010
• 特集・制がん剤の分子標的スクリーニング成績 「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第13報-

  癌と化学療法 2010
• ヒトがん細胞パネルによる分子標的薬スクリーニング（日本がん分子標的治療学会編「がん分子標的治療研究 実践マニュアル」53-58/329ページ）

  京都: 金芳堂 2009
• 癌領域におけるPI3キナーゼ阻害剤の開発

  Medical Science Digest 2009
• 分子標的薬の基礎および研究動向（山本重夫編「バイオ医薬の開発技術とシーズ」3-11/384ページ）

  東京: シーエムシー出版 2009
• アカデミアの立場からの新薬開発支援（西條長宏・西尾和人編「がん化学療法・分子標的治療 update」138-142/733ページ）

  東京: 中外医学社 2009
• PI3K-Akt-mTOR経路

  カレントテラピー 2009
• 分子標的薬創薬に有用なCancer Cell Informaticsの構築と応用

  展望 Promising Vistas in Cancer Research 2009
• 総論 分子標的薬の動向

  細胞 The CELL 2009
• PI3K阻害剤開発の現状

  細胞 The CELL 2009
• Cancer Cell Informaticsと分子標的薬剤（鶴尾隆編「がんの分子標的治療」17-22/441ページ）

  東京: 南山堂 2008
• 癌細胞に関する増殖因子の測定法（日本がん転移学会編「がん転移研究の実験手法」205-208/362ページ）

  京都: 金芳堂 2008
• Cancer Cell Informaticsの活用と分子標的薬の探索評価

  Mebio Oncology 2008
• がん分子標的研究の基盤となるCancer Cell Informatics

  MEDCHEM NEWS 2008
• プロテオミクスによる薬剤感受性の検討

  腫瘍内科 2008
• PI3Kの新しい阻害剤

  生体の科学 2008
• 新規PI3キナーゼ阻害剤ZSTK474の抗がん活性

  細胞 The CELL 2007
• 分子標的治療薬の開発と発展

  日本病院薬剤師会雑誌 2007
• 分子標的治療薬

  クリニカル プラクティス 2007
• 特集・制がん剤の分子標的スクリーニング成績 「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第12報-

  癌と化学療法 2007
• 特集・制がん剤の分子標的スクリーニング成績 「新しい戦略による抗がん剤のスクリーニングのための委員会」報告-制がん候補物質のスクリーニング成績・第11報-

  癌と化学療法 2007
• 分子標的治療薬とは

  月刊薬事 2007
• Cancer Cell Informaticsとケミカルバイオロジー

  蛋白質 核酸 酵素 2007
• 分子標的治療薬のオーバービュー

  Drug Delivery System 2006
• 分子標的療法の開発と発展

  血液フロンティア 2006
• 抗がん剤応答性の予測におけるマイクロアレイ解析

  JBiotherapy 2005
• ランダムスクリーニングからtarget-basedスクリーニングへ（西條長宏編「癌治療の新たな試み 医薬ジャーナル 新編Ⅲ」36-53/798ページ）

  2005
• 代表的な抗悪性腫瘍薬を列挙できる．（日本薬学会編「薬と疾病 Ⅲ薬物治療(2)および薬物治療に役立つ情報」98-100/316ページ）

  東京: 東京化学同人 2005
• 代表的な抗悪性腫瘍薬の基本構造を示すことができる．（日本薬学会編「薬と疾病 Ⅲ薬物治療(2)および薬物治療に役立つ情報」101-103/316ページ）

  東京: 東京化学同人 2005
• 代表的な代謝拮抗薬を列挙し、作用機序を説明できる．（日本薬学会編「薬と疾病 Ⅲ薬物治療(2)および薬物治療に役立つ情報」104-106/316ページ）

  東京: 東京化学同人 2005
• プロテオミクスによる大腸癌マーカーの探索

  GI Research 2005
• ヒトがん細胞パネルによる化合物の分子薬理の評価と抗がん剤感受性関連遺伝子

  がん分子標的治療 2004
• Cancer Cell Informaticsと抗がん薬検索

  臨床医薬 2004
• Cancer Cell Informatics －抗がん剤探索とポストゲノム研究への応用－

  バイオサイエンスとインダストリー 2004
• Cancer Cell Informaticsと抗がん剤探索

  Jpn J Clin Pharmcol Ther 2004
• 制がん剤の分子標的スクリーニング成績-わが国における制がん剤候補物質のスクリーニング成績・第10報-

  癌と化学療法 2004
• がん細胞パネルによる化合物評価とその分子標的スクリーニングにおける役割

  癌と化学療法 2004
• 癌分子標的と創薬スクリーニング

  現代医療 2004
• 遺伝子発現情報を用いた抗がん剤感受性予測

  血液・腫瘍科 2003
• がん化学療法感受性と遺伝子発現

  分子細胞治療 2003
• ヒストン脱アセチル化酵素阻害剤

  Surgery Frontier 2003
• Cancer Cell Informaticsによる制癌剤のスクリーニング

  Surgery Frontier 2003
• がん細胞パネルインフォーマティクス - 分子標的治療薬探索と感受性診断への応用

  Drug Delivery System 2003
• がん細胞パネル -抗がん剤 探索およびポストゲノム研究における活用-.

  東京: 癌と化学療法社 2003
• Shoemaker R. 分子標的治療薬の開発戦略

  がん分子標的治療 2003
• 抗がん剤スクリーニングの変遷

  化学療法の領域 2003
• ケモカインとがん転移

  日本臨床 2003
• 制がん剤の分子標的スクリーニング成績-わが国における制がん剤候補物質のスクリーニング成績・第9報-

  癌と化学療法 2002
• 分子標的薬剤のバイオインフォーマティクス

  現代医療 2000
• 制がん剤の分子標的スクリーニング成績-わが国における制がん剤候補物質のスクリーニング成績・第8報-

  癌と化学療法 2000
• がん転移の臓器親和性を決定する因子の解析

  がん治療のあゆみ 1999
• 抗癌剤開発・基礎ーヒト培養がん細胞パネルによるスクリーニングを中心に

  東京: 癌と化学療法社 1999
• 増殖因子、サイトカインによる癌細胞増殖促進

  癌と化学療法 1999
• 消化器癌の転移における宿主因子の意義

  Frontiers in Gastroenterology 1998
• 増殖因子：癌転移の臓器親和性とのかかわり

  東京: 医薬ジャーナル社 1998
• わが国における制がん剤候補物質のスクリーニング成績・第7報

  癌と化学療法 1998
• 臓器微小環境と癌転移

  実験医学 1998
• ヒト培養癌細胞パネルによるスクリーニング

  癌と化学療法 1997
• in vivo 実験転移モデルの発展

  Biotherapy 1997
• 抗がん剤スクリーニングの新手法

  化学と薬学の教室 1996
• 肝転移と肝由来増殖因子

  肝胆膵 1996
• 臓器特異的転移の分子機構

  東京: 中外医学社 1996
• スクリーニング

  東京: 中外医学社 1996
• 臓器親和性を決定する宿主因子

  羊土社 1996
• 手術侵襲による肝転移増大モデル

  侵襲と免疫 1996
• 肝細胞の産生するがん細胞増殖促進因子ーその肝転移への関与

  Biotherapy 1996
• ヌードマウス移植ヒト胃癌に対するDoxiflurdine, PirarubicinおよびCisplatin の３剤併用療法

  22癌と化学療法 1995
• 癌細胞の増殖因子への感受性の測定法

  京都: 金芳堂 1994
• 転移性がん細胞株の樹立法

  京都: 金芳堂 1994
• 経脾モデル

  京都: 金芳堂 1994
• 世界における転移モデル動物実験の総括

  実験医学 1994
• 転移に関係する増殖因子

  臨床科学 1993
• 転移に関与する癌細胞の血小板凝集因子と増殖因子

  Oncologia 1993
• 高転移性細胞におけるインスリン様増殖因子 I ( IGF-I ) のシグナル伝達

  癌と化学療法 1993
• ヒト培養癌細胞パネルによるスクリーニング

  中外医学社 1993
• 臓器特異的転移と増殖因子

  Mebio 1992
• 臓器選択的転移の分子レベルでの裏付け.

  細胞工学 1992
• 新抗がん剤と転移抑制剤ー日米癌共同セミナーより

  癌と化学療法 1991
• 癌転移と増殖因子

  蛋白質・核酸・酵素 1991
• 癌転移阻害物質の検索

  続医薬品の開発（名取俊二、中西義信編） 1991
• 癌転移を抑える遺伝子はあるのか？

  蛋白質 核酸 酵素 1990
• 癌転移と増殖因子.

  癌と化学療法 1989
• 癌転移研究の進歩-糖鎖抗原との関連

  ファルマシア 1989
• 増殖因子と癌転移

  Biomedica 1989
• 転移巣における増殖因子

  実験医学 1989
• 糖鎖抗原と癌転移

  実験医学 1988
• がん転移研究の推移－アメリカ癌学会印象記

  Oncologia 1986
• 臓器特異性転移株の選別

  日本医師会雑誌 1985

MISC

• Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model

  Yusuke Matsumoto; Hironori Tsujimoto; Satoshi Ono; Nariyoshi Shinomiya; Hiromi Miyazaki; Shuichi Hiraki; Risa Takahata; Kazumichi Yoshida; Daizoh Saitoh; Takao Yamori; Junji Yamamoto; Kazuo Hase  ANNALS OF SURGICAL ONCOLOGY  23-  257  -265  2016/02
• Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation

  Tetsuo Mashima; Masaru Ushijima; Masaaki Matsuura; Satomi Tsukahara; Kazuhiro Kunimasa; Aki Furuno; Sakae Saito; Masami Kitamura; Taeko Soma-Nagae; Hiroyuki Seimiya; Shingo Dan; Takao Yamori; Akihiro Tomida  CANCER SCIENCE  106-  (7)  909  -920  2015/07
• Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca2+ pumps with a unique mode of binding

  Maho Morita; Haruo Ogawa; Osamu Ohno; Takao Yamori; Kiyotake Suenaga; Chikashi Toyoshima  FEBS LETTERS  589-  (13)  1406  -1411  2015/06
• Extensive analysis of signaling pathway molecules in breast cancer: association with clinicopathological characteristics

  Rie Horii; Masaaki Matsuura; Shingo Dan; Masaru Ushijima; Natsue Uehiro; Akiko Ogiya; Naoko Honma; Yoshinori Ito; Takuji Iwase; Takao Yamori; Futoshi Akiyama  INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY  20-  (3)  490  -498  2015/06
• Synthesis of dansyl-labeled probe of thiophene analogue of annonaceous acetogenins for visualization of cell distribution and growth inhibitory activity toward human cancer cell lines

  Naoto Kojima; Yuki Suga; Takuya Matsumoto; Tetsuaki Tanaka; Akinobu Akatsuka; Takao Yamori; Shingo Dan; Hiroki Iwasaki; Masayuki Yamashita  BIOORGANIC & MEDICINAL CHEMISTRY  23-  (6)  1276  -1283  2015/03
• Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNF alpha-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

  Manabu Kawada; Hiroyuki Inoue; Shun-ichi Ohba; Junjiro Yoshida; Tohru Masuda; Manabu Yamasaki; Ihomi Usami; Shuichi Sakamoto; Hikaru Abe; Takumi Watanabe; Takao Yamori; Masakatsu Shibasaki; Akio Nomoto  PLOS ONE  10-  (3)  2015/03
• Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474

  Sho Isoyama; Gensei Kajiwara; Naomi Tamaki; Mutsumi Okamura; Hisashi Yoshimi; Naoki Nakamura; Kento Kawamura; Yumiko Nishimura; Nachi Namatame; Takao Yamori; Shingo Dan  CANCER SCIENCE  106-  (2)  171  -178  2015/02
• Securing the future of drug discovery for central nervous system disorders

  Peter Hongaard Andersen; Richard Moscicki; Barbara Sahakian; Remi Quirion; Ranga Krishnan; Tim Race; Anthony Phillips  NATURE REVIEWS DRUG DISCOVERY  13-  (12)  871  -872  2014/12
• Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead

  Naoto Kojima; Tetsuya Fushimi; Takahiro Tatsukawa; Tetsuaki Tanaka; Mutsumi Okamura; Akinobu Akatsuka; Takao Yamori; Shingo Dan; Hiroki Iwasaki; Masayuki Yamashita  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY  86-  684  -689  2014/10
• A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells

  R. Yao; Y. Kondoh; Y. Natsume; H. Yamanaka; M. Inoue; H. Toki; R. Takagi; T. Shimizu; T. Yamori; H. Osada; T. Noda  ONCOGENE  33-  (33)  4242  -4252  2014/08
• In Vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells

  Sheng-An Tang; Qianxiang Zhou; Wen-Zhi Guo; Yuling Qiu; Ran Wang; Meihua Jin; Wenjing Zhang; Ke Li; Takao Yamori; Shingo Dan; Dexin Kong  MARINE DRUGS  12-  (7)  4200  -4213  2014/07
• Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity

  Yurie Fukui; Koichi Narita; Singo Dan; Takao Yamori; Akihiro Ito; Minoru Yoshida; Tadashi Katoh  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY  76-  301  -313  2014/04
• Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement

  Yukitoshi Nagahara; Midori Takeyoshi; Seiya Sakemoto; Isamu Shiina; Kenya Nakata; Keiko Fujimori; Yanwen Wang; Eri Umeda; Chihiro Watanabe; Shoko Uetake; Takao Yamori; Shingo Dan; Yoji Yoshimi; Takahisa Shinomiya; Masahiko Ikekita  Biochemical and Biophysical Research Communications  435-  (4)  657  -663  2013/06
• Search for novel anti-tumor agents from ridaifens using JFCR39, a panel of human cancer cell lines

  Wen-Zhi Guo; Yanwen Wang; Eri Umeda; Isamu Shiina; Shingo Dan; Takao Yamori  Biological and Pharmaceutical Bulletin  36-  (6)  1008  -1016  2013/06
• Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition.

  Ryohei Katayama; Aki Aoyama; Takao Yamori; Jie Qi; Tomoko Oh-hara; Youngchul Song; Jeffrey A Engelman; Naoya Fujita  Cancer research  73-  (10)  3087  -96  2013/05
• Structure-activity relationships of hybrid annonaceous acetogenins: Powerful growth inhibitory effects of their connecting groups between heterocycle and hydrophobic carbon chain bearing THF ring on human cancer cell lines

  Naoto Kojima; Tetsuya Fushimi; Takahiro Tatsukawa; Takehiko Yoshimitsu; Tetsuaki Tanaka; Takao Yamori; Shingo Dan; Hiroki Iwasaki; Masayuki Yamashita  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY  63-  833  -839  2013/05
• Development of a gene expression database and related analysis programs for evaluation of anticancer compounds

  Masaru Ushijima; Tetsuo Mashima; Akihiro Tomida; Shingo Dan; Sakae Saito; Aki Furuno; Satomi Tsukahara; Hiroyuki Seimiya; Takao Yamori; Masaaki Matsuura  CANCER SCIENCE  104-  (3)  360  -368  2013/03
• Identification of Transporters Associated with Etoposide Sensitivity of Stomach Cancer Cell Lines and Methotrexate Sensitivity of Breast Cancer Cell Lines by Quantitative Targeted Absolute Proteomics

  Wataru Obuchi; Sumio Ohtsuki; Yasuo Uchida; Ken Ohmine; Takao Yamori; Tetsuya Terasaki  MOLECULAR PHARMACOLOGY  83-  (2)  490  -500  2013/02
• Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities

  Koichi Narita; Yurie Fukui; Yui Sano; Takao Yamori; Akihiro Ito; Minoru Yoshida; Tadashi Katoh  European Journal of Medicinal Chemistry  60-  295  -304  2013/02
• Total Synthesis of AMF-26, an Antitumor Agent for Inhibition of the Golgi System, Targeting ADP-Ribosylation Factor 1

  Isamu Shiina; Yuma Umezaki; Yoshimi Ohashi; Yuta Yamazaki; Shingo Dan; Takao Yamori  JOURNAL OF MEDICINAL CHEMISTRY  56-  (1)  150  -159  2013/01
• Synthesis of antitumor azolato-bridged dinuclear platinum(II) complexes with in vivo antitumor efficacy and unique in vitro cytotoxicity profiles

  Seiji Komeda; Hiroshi Takayama; Toshihiro Suzuki; Akira Odani; Takao Yamori; Masahiko Chikuma  METALLOMICS  5-  (5)  461  -468  2013
• Establishment of phosphatidylinositol 3-kinase inhibitor-resistant cancer cell lines and therapeutic strategies for overcoming the resistance

  Sho Isoyama; Shingo Dan; Yumiko Nishimura; Naoki Nakamura; Gensei Kajiwara; Mariko Seki; Tatsuro Irimura; Takao Yamori  CANCER SCIENCE  103-  (11)  1955  -1960  2012/11
• Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides

  Maho Morita; Osamu Ohno; Toshiaki Teruya; Takao Yamori; Toshiyasu Inuzuka; Kiyotake Suenaga  TETRAHEDRON  68-  (30)  5984  -5990  2012/07
• Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants

  Ken-ichi Kimura; Yoshimi Sakamoto; Nozomi Fujisawa; Shota Uesugi; Nobuhiro Aburai; Manabu Kawada; Shun-ichi Ohba; Takao Yamori; Eiko Tsuchiya; Hiroyuki Koshino  BIOORGANIC & MEDICINAL CHEMISTRY  20-  (12)  3887  -3897  2012/06
• Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats

  Kazuhiko Haruta; Shigeyuki Mori; Naoto Tamura; Asako Sasaki; Masakazu Nagamine; Shin-ichi Yaguchi; Fumitaka Kamachi; Jumpei Enami; Shigeto Kobayashi; Takao Yamori; Yoshinari Takasaki  INFLAMMATION RESEARCH  61-  (6)  551  -562  2012/06
• ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo

  Shingo Dan; Mutsumi Okamura; Yumiko Mukai; Hisashi Yoshimi; Yasumichi Inoue; Aki Hanyu; Asako Sakaue-Sawano; Takeshi Imamura; Atsushi Miyawaki; Takao Yamori  EUROPEAN JOURNAL OF CANCER  48-  (6)  936  -943  2012/04
• Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb

  Takeshi Miyazaki; Yang Pan; Kaushal Joshi; Deepti Purohit; Bin Hu; Habibe Demir; Sarmistha Mazumder; Sachiko Okabe; Takao Yamori; Mariano Viapiano; Kazuo Shin-ya; Hiroyuki Seimiya; Ichiro Nakano  CLINICAL CANCER RESEARCH  18-  (5)  1268  -1280  2012/03
• JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs

  Dexin Kong; Takao Yamori  BIOORGANIC & MEDICINAL CHEMISTRY  20-  (6)  1947  -1951  2012/03
• AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy

  Yoshimi Ohashi; Hiroshi Iijima; Noriyuki Yamaotsu; Kanami Yamazaki; Shigeo Sato; Mutsumi Okamura; Kenji Sugimoto; Shingo Dan; Shuichi Hirono; Takao Yamori  JOURNAL OF BIOLOGICAL CHEMISTRY  287-  (6)  3885  -3897  2012/02
• Disruption of Tacc3 function leads to in vivo tumor regression

  R. Yao; Y. Natsume; Y. Saiki; H. Shioya; K. Takeuchi; T. Yamori; H. Toki; I. Aoki; T. Saga; T. Noda  ONCOGENE  31-  (2)  135  -148  2012/01
• Potentiation of Bleomycin in Jurkat Cells by Fungal Pycnidione

  Mayumi Kaneko; Daisuke Matsuda; Masaki Ohtawa; Takashi Fukuda; Tohru Nagamitsu; Takao Yamori; Hiroshi Tomoda  BIOLOGICAL & PHARMACEUTICAL BULLETIN  35-  (1)  18  -28  2012/01
• Development of an immunohistochemical protein quantification system in conjunction with tissue microarray technology for identifying predictive biomarkers for phosphatidylinositol 3-kinase inhibitors.

  Isoyama S; Yoshimi H; Dan S; Okamura M; Seki M; Irimura T; Yamori T  Biol Pharm Bull.  35-  (9)  1607  -13  2012
• Identification of Chrysoplenetin from Vitex negundo as a Potential Cytotoxic Agent against PANC-1 and a Panel of 39 Human Cancer Cell Lines (JFCR-39)

  Suresh Awale; Thein Zaw Linn; Feng Li; Yasuhiro Tezuka; Aung Myint; Akihiro Tomida; Takao Yamori; Hiroyasu Esumi; Shigetoshi Kadota  PHYTOTHERAPY RESEARCH  25-  (12)  1770  -1775  2011/12
• Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines

  Naoto Kojima; Yuki Suga; Hiromi Hayashi; Takao Yamori; Takehiko Yoshimitsu; Tetsuaki Tanaka  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  21-  (19)  5745  -5749  2011/10
• Inhibitory Activity of Flavonoids against Class I Phosphatidylinositol 3-Kinase Isoforms

  Dexin Kong; Yanwen Zhang; Takao Yamori; Hongquan Duan; Meihua Jin  MOLECULES  16-  (6)  5159  -5167  2011/06
• Effectiveness of combined treatment using X-rays and a phosphoinositide 3-kinase inhibitor, ZSTK474, on proliferation of HeLa cells in vitro and in vivo

  Kazunori Anzai; Emiko Sekine-Suzuki; Megumi Ueno; Mutsumi Okamura; Hisashi Yoshimi; Shingo Dan; Shin-ichi Yaguchi; Jumpei Enami; Takao Yamori; Ryuichi Okayasu  CANCER SCIENCE  102-  (6)  1176  -1180  2011/06
• Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.

  Ivan S Donev; Wei Wang; Tadaaki Yamada; Qi Li; Shinji Takeuchi; Kunio Matsumoto; Takao Yamori; Yasuhiko Nishioka; Saburo Sone; Seiji Yano  Clinical cancer research : an official journal of the American Association for Cancer Research  17-  (8)  2260  -9  2011/04
• Antiproliferative and Antiangiogenic Activities of Smenospongine, a Marine Sponge Sesquiterpene Aminoquinone

  Dexin Kong; Takao Yamori; Motomasa Kobayashi; Hongquan Duan  MARINE DRUGS  9-  (2)  154  -161  2011/02
• Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting

  Mami Murakami; Horacio Cabral; Yu Matsumoto; Shourong Wu; Mitsunobu R. Kano; Takao Yamori; Nobuhiro Nishiyama; Kazunori Kataoka  SCIENCE TRANSLATIONAL MEDICINE  3-  (64)  64ra62  2011/01
• Total synthesis and biological assessment of (-)-exiguolide and analogues.

  Fuwa H; Suzuki T; Kubo H; Yamori T; Sasaki M  Chemistry  17-  (9)  2678  -88  2011
• Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution

  Naoto Kojima; Takekuni Morioka; Daisuke Urabe; Masahiro Yano; Yuki Suga; Naoyoshi Maezaki; Ayako Ohashi-Kobayashi; Yasuyuki Fujimoto; Masatomo Maeda; Takao Yamori; Takehiko Yoshimitsu; Tetsuaki Tanaka  BIOORGANIC & MEDICINAL CHEMISTRY  18-  (24)  8630  -8641  2010/12
• Yaku'amides A and B, Cytotoxic Linear Peptides Rich in Dehydroamino Acids from the Marine Sponge Ceratopsion sp.

  Reiko Ueoka; Yuji Ise; Susumu Ohtsuka; Shigeru Okada; Takao Yamori; Shigeki Matsunaga  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  132-  (50)  17692  -17694  2010/12
• Cytochrome P450 1B1 Gene Polymorphisms as Predictors of Anticancer Drug Activity: Studies with In vitro Models

  Audrey Laroche-Clary; Valerie Le Morvan; Takao Yamori; Jacques Robert  MOLECULAR CANCER THERAPEUTICS  9-  (12)  3315  -3321  2010/12
• Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations

  Miyako Hiramatsu; Hironori Ninomiya; Kentaro Inamura; Kimie Nomura; Kengo Takeuchi; Yukitoshi Satoh; Sakae Okumura; Ken Nakagawa; Takao Yamori; Masaaki Matsuura; Toshiaki Morikawa; Yuichi Ishikawa  LUNG CANCER  70-  (1)  94  -102  2010/10
• The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor

  Yuichiro Ihara; Yasuyuki Kihara; Fumie Hamano; Keisuke Yanagida; Yasuyuki Morishita; Akiko Kunita; Takao Yamori; Masashi Fukayama; Hiroyuki Aburatani; Takao Shimizu; Satoshi Ishii  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  107-  (40)  17309  -17314  2010/10
• ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system

  De-xin Kong; Takao Yamori  ACTA PHARMACOLOGICA SINICA  31-  (9)  1189  -1197  2010/09
• Correlation between Cytotoxic Activities and Reduction Potentials of Heterocyclic Quinones

  Junko Koyama; Izumi Morita; Takao Yamori  MOLECULES  15-  (9)  6559  -6569  2010/09
• Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status: In silico and Biological Evaluations

  Shingo Dan; Mutsumi Okamura; Mariko Seki; Kanami Yamazaki; Hironobu Sugita; Michiyo Okui; Yumiko Mukai; Hiroyuki Nishimura; Reimi Asaka; Kimie Nomura; Yuichi Ishikawa; Takao Yamori  CANCER RESEARCH  70-  (12)  4982  -4994  2010/06
• Triterpene Glycosides from Curculigo orchioides and Their Cytotoxic Activity

  Akihito Yokosuka; Koji Sato; Takao Yamori; Yoshihiro Mimaki  JOURNAL OF NATURAL PRODUCTS  73-  (6)  1102  -1106  2010/06
• Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39

  Dexin Kong; Shingo Dan; Kanami Yamazaki; Takao Yamori  EUROPEAN JOURNAL OF CANCER  46-  (6)  1111  -1121  2010/04
• Synthesis and Preclinical Evaluations of 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-one Monosodium Phosphate (CHM-1-P-Na) as a Potent Antitumor Agent

  Li-Chen Chou; Chien-Ting Chen; Jang-Chang Lee; Tzong-Der Way; Chi-Hung Huang; Shih-Ming Huang; Che-Ming Teng; Takao Yamori; Tian-Shung Wu; Chung-Ming Sun; Du-Shieng Chien; Keduo Qian; Susan L. Morris-Natschke; Kuo-Hsiung Lee; Li-Jiau Huang; Sheng-Chu Kuo  JOURNAL OF MEDICINAL CHEMISTRY  53-  (4)  1616  -1626  2010/02
• Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions

  Isao Momose; Shun-ichi Ohba; Daisuke Tatsuda; Manabu Kawada; Tohru Masuda; Go Tsujiuchi; Takao Yamori; Hiroyasu Esumi; Daishiro Ikeda  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  392-  (3)  460  -466  2010/02
• Discovery of Phosphatidylinositol 3-Kinase inhibitory compounds from the Screening Committee of Anticancer Drugs (SCADS) library.

  Kong D; Yamazaki K; Yamori T  Biol Pharm Bull  33-  (9)  1600  -1604  2010
• Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice

  Shoko Toyama; Naoto Tamura; Kazuhiko Haruta; Takeo Karakida; Shigeyuki Mori; Tetsuo Watanabe; Takao Yamori; Yoshinari Takasaki  ARTHRITIS RESEARCH & THERAPY  12-  (3)  R92  2010
• Identification of Candidate Genes Determining Chemosensitivity to Anti-cancer Drugs of Gastric Cancer Cell Lines

  Tomoki Nakamura; Noriyuki Nakatsu; Yoko Yoshida; Kanami Yamazaki; Shingo Dan; Soutaro Sadahiro; Hiroyasu Makuuchi; Takao Yamori  BIOLOGICAL & PHARMACEUTICAL BULLETIN  32-  (11)  1936  -1939  2009/11
• Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity

  Takahiro Nomura; Yoshimasa Uehara; Hiroo Kawajiri; Kazuo Ryoyama; Takao Yamori; Yoko Fuke  CANCER EPIDEMIOLOGY  33-  (3-4)  288  -292  2009/10
• The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models

  N. Faur; L. Araud; A. Laroche-Clary; J. Kanno; J. Toutain; T. Yamori; J. Robert; V. Le Morvan  BRITISH JOURNAL OF CANCER  101-  (2)  350  -356  2009/07
• Design, Synthesis, and Biological Activity of Boronic Acid-Based Histone Deacetylase Inhibitors

  Nobuaki Suzuki; Takayoshi Suzuki; Yosuke Ota; Tatsuya Nakano; Masaaki Kurihara; Haruhiro Okuda; Takao Yamori; Hiroki Tsumoto; Hidehiko Nakagawa; Naoki Miyata  JOURNAL OF MEDICINAL CHEMISTRY  52-  (9)  2909  -2922  2009/05
• Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor

  Dexin Kong; Mutsumi Okamura; Hisashi Yoshimi; Takao Yamori  EUROPEAN JOURNAL OF CANCER  45-  (5)  857  -865  2009/03
• Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS

  Tetsuyuki Akashi; Takao Yamori  PROTEOME SCIENCE  7-  14  2009/03
• Effect of ZSTK474, a Novel Phosphatidylinositol 3-Kinase Inhibitor, on DNA-Dependent Protein Kinase

  Dexin Kong; Shin-ichi Yaguchi; Takao Yamori  BIOLOGICAL & PHARMACEUTICAL BULLETIN  32-  (2)  297  -300  2009/02
• Advances in development of phosphatidylinositol 3-kinase inhibitors.

  Kong D; Yamori T  Current medicinal chemistry  16-  2839  -54  2009
• Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G(0)/G(1) arrest

  Shingo Dan; Hisashi Yoshimi; Mutsumi Okamura; Yumiko Mukai; Takao Yamori  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  379-  (1)  104  -109  2009/01
• Total Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5 ''-epi-Spiruchostatin B, FK228 (FR901228) and Preliminary Evaluation of Their Biological Activity

  Koichi Narita; Takuya Kikuchi; Kazuhiro Watanabe; Toshiya Takizawa; Takamasa Oguchi; Kyosuke Kudo; Keisuke Matsuhara; Hideki Abe; Takao Yamori; Minoru Yoshida; Tadashi Katoh  CHEMISTRY-A EUROPEAN JOURNAL  15-  (42)  11174  -11186  2009
• SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-beta Signal in Gastric Cancer Cells

  Mami Takahata; Yasumichi Inoue; Hitoshi Tsuda; Issei Imoto; Daizo Koinuma; Makoto Hayashi; Takashi Ichikura; Takao Yamori; Koichi Nagasaki; Mika Yoshida; Masao Matsuoka; Kazuhiro Morishita; Keiko Yuki; Aki Hanyu; Keiji Miyazawa; Johji Inazawa; Kohei Miyazono; Takeshi Imamura  JOURNAL OF BIOLOGICAL CHEMISTRY  284-  (5)  3334  -3344  2009/01
• A new evaluation method for quantifying PI3K activity by HTRF assay

  Hironobu Sugita; Shingo Dan; Dexin Kong; Akihiro Tomida; Takao Yamori  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  377-  (3)  941  -945  2008/12
• Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines

  Naoto Kojima; Hiromi Hayashi; Satoshi Suzuki; Hiroaki Tominaga; Naoyoshi Maezaki; Tetsuaki Tanaka; Takao Yamori  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  18-  (24)  6451  -6453  2008/12
• The polar neutral and basic taxoids isolated from needles and twigs of Taxus cuspidata and their biological activity

  Liyan Wang; Liming Bai; Daisuke Tokunaga; Yusuke Watanabe; Toshiaki Hasegawa; Jun-ichi Sakai; Wanxia Tang; Yuhua Bai; Katsutoshi Hirose; Takao Yamori; Akihiro Tomida; Takashi Tsuruo; Masayoshi Ando  JOURNAL OF WOOD SCIENCE  54-  (5)  390  -401  2008/10
• Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy

  Dexin Kong; Takao Yamori  CANCER SCIENCE  99-  (9)  1734  -1740  2008/09
• Synthesis of hybrid acetogenins, alpha,beta-unsaturated-gamma-lactone-free nitrogen-containing heterocyclic analogues, and their cytotoxicity against human cancer cell lines

  Naoto Kojima; Tetsuya Fushimi; Naoyoshi Maezaki; Tetsuaki Tanaka; Takao Yamori  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  18-  (5)  1637  -1641  2008/03
• Synthesis and pharmacological evaluation of the novel pseudo-symmetrical tamoxifen derivatives as anti-tumor agents

  Isamu Shiina; Yoshiyuki Sano; Kenya Nakata; Takaaki Kikuchi; Akane Sasaki; Masahiko Ikekita; Yukitoshi Nagahara; Yoshimune Hasome; Takao Yamori; Kanami Yamazaki  BIOCHEMICAL PHARMACOLOGY  75-  (5)  1014  -1026  2008/03
• Motif-programmed artificial protein induces apoptosis in several cancer cells by disrupting mitochondria

  Hirohide Saito; Tamiko Minamisawa; Takao Yamori; Kiyotaka Shiba  CANCER SCIENCE  99-  (2)  398  -406  2008/02
• Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226

  Chun-Jen Chen; Mei-Hua Hsu; Li-Jiau Huang; Takao Yamori; Fing-Gung Chung; Fang-Yu Lee; Che-Ming Teng; Sheng-Chu Kuo  BIOCHEMICAL PHARMACOLOGY  75-  (2)  360  -368  2008/01
• Evaluation of action mechanisms of toxic chemicals using JFCR39, a panel of human cancer cell lines

  Noriyuki Nakatsu; Tomoki Nakamura; Kanami Yamazaki; Soutaro Sadahiro; Hiroyasu Makuuchi; Jun Kanno; Takao Yamori  MOLECULAR PHARMACOLOGY  72-  (5)  1171  -1180  2007/11
• Variation in cytostatic constituents of a sponge-derived Gymnascella dankaliensis by manipulating the carbon source

  Taro Amagata; Makoto Tanaka; Takeshi Yamada; Mitsunobu Doi; Katsuhiko Minoura; Hirofumi Ohishi; Takao Yamori; Atsushi Numata  JOURNAL OF NATURAL PRODUCTS  70-  (11)  1731  -1740  2007/11
• Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor

  Takayuki Yamaguchi; Takayuki Yoshida; Reina Kurachi; Junya Kakegawa; Yoshikazu Hori; Toyomichi Nanayama; Kazuhide Hayakawa; Hiroyuki Abe; Koichi Takagi; Youichirou Matsuzaki; Makoto Koyama; Shingo Yogosawa; Yoshihiro Sowa; Takao Yamori; Nobuyuki Tajima; Toshiyuki Sakai  CANCER SCIENCE  98-  (11)  1809  -1816  2007/11
• ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms

  Dexin Kong; Takao Yamori  CANCER SCIENCE  98-  (10)  1638  -1642  2007/10
• Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad

  Kazuhiro Ichikawa; Emiko Sakabe; Ken-Ichiro Kuninobu; Takao Yamori; Takashi Tsuruo; Takashi Yao; Masazumi Tsuneyoshi; Hideo Utsumi  ANTIOXIDANTS & REDOX SIGNALING  9-  (10)  1699  -1707  2007/10
• Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells

  Kazuhiro Ishizu; Naohide Sunose; Kanami Yamazaki; Takashi Tsuruo; Sotaro Sadahiro; Hiroyasu Makuuchi; Takao Yamori  BIOLOGICAL & PHARMACEUTICAL BULLETIN  30-  (9)  1779  -1783  2007/09
• A novel candidate compound with urethane structure for anticancer drug development

  Atsuko Matsuoka; Kazuo Isama; Susumu Tanimura; Michiaki Kohno; Takao Yamori  Current Drug Discovery Technologies  4-  (2)  69  -76  2007/08
• Rapid communication - A novel method for analyzing phosphoproteins using SELDI-TOF MS in combination with a series of recombinant proteins

  Tetsuyuki Akashi; Takao Yamori  PROTEOMICS  7-  (14)  2350  -2354  2007/07
• Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells

  Toshiaki Hasegawa; Jiao Bai; Jungui Dai; Liming Bai; Junichi Sakai; Shigenori Nishizawa; Yuhua Bai; Midorl Kikuchi; Mariko Abe; Takao Yamori; Akihiro Tomida; Takashi Tsuruo; Katsutoshi Hirose; Masayoshi Ando  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  17-  (13)  3722  -3728  2007/07
• Comparative profiling of the gene expression for estrogen responsiveness in cultured human cell lines

  Akio Inoue; Yuko Seino; Shunichi Terasaka; Shin-ichi Hayashi; Takao Yamori; Masao Tanji; Ryoiti Kiyama  TOXICOLOGY IN VITRO  21-  (4)  741  -752  2007/06
• Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells

  Akihito Yokosuka; Mitsue Haraguchi; Takeo Usui; Sayaka Kazami; Hiroyuki Osada; Takao Yamori; Yoshihiro Mimaki  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  17-  (11)  3091  -3094  2007/06
• Absolute quantification of four isoforms of the class I phosphoinositide-3-kinase catalytic subunit by real-time RT-PCR.

  Nakamura H; Dan S; Akashi T; Unno M; Yamori T  Biological & pharmaceutical bulletin  30-  (6)  1181  -1184  2007
• Proteomics-based identification of biomarkers for predicting sensitivity to a PI3-kinase inhibitor in cancer

  Tetsuyuki Akashi; Yumiko Nishimura; Rumi Wakatabe; Mieko Shiwa; Takao Yamori  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  352-  (2)  514  -521  2007/01
• Enantioselective total synthesis of (+)-ottelione A, (-)-ottelione B, (+)-3-epi-ottelione a and preliminary evaluation of their antitumor activity

  Hiroshi Araki; Munenori Inoue; Takeyuki Suzuki; Takao Yamori; Michiaki Kohno; Kazuhiro Watanabe; Hideki Abe; Tadashi Katoh  CHEMISTRY-A EUROPEAN JOURNAL  13-  (35)  9866  -9881  2007
• Marine diterpenoids with a briarane skeleton from the Okinawan soft coral Pachyclavularia violacea.

  Ito H; Iwasaki J; Sato Y; Aoyagi M; Iguchi K; Yamori T  Chem Pharm Bull (Tokyo)  55-  (12)  1671  -6  2007
• Sesquiterpenoids and flavonoids from the aerial parts of Tithonia diversifolia and their cytotoxic activity.

  Kuroda M; Yokosuka A; Kobayashi R; Jitsuno M; Kando H; Nosaka K; Ishii H; Yamori T; Mimaki Y  Chem Pharm Bull (Tokyo)  55-  (8)  1240  -4  2007
• Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. I. Fermentation, isolation and biological activities.

  Matsuo Y; Kanoh K; Yamori T; Kasai H; Katsuta A; Adachi K; Shin-Ya K; Shizuri Y  J Antibiot (Tokyo)  60-  (4)  251  -5  2007
• Potent antitumor activity of 3,4-seco-8 beta H-ferna-4(23),9(11)-dien-3-oic acid (EC-2) and 3,4-seco-oleana-4(23), 18-dien-3-oic acid (EC-4), evaluated by an in vitro human cancer cell line panel

  Reiko Tanaka; Shun-ichi Wada; Takeshi Yamada; Takao Yamori  PLANTA MEDICA  72-  (14)  1347  -1349  2006/11
• Synthesis and biological evaluation of boronic acid containing cis-stilbenes as apoptotic tubulin polymerzation inhibitors

  Hiroyuki Nakamura; Hirokazu Kuroda; Hiroyuki Saito; Ryo Suzuki; Takao Yamori; Kazuo Maruyama; Tatsuya Haga  CHEMMEDCHEM  1-  (7)  729  -740  2006/07
• Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine TO lysophosphatidic acid

  Y Kishi; S Okudaira; M Tanaka; K Hama; D Shida; J Kitayama; T Yamori; J Aoki; T Fujimaki; H Arai  JOURNAL OF BIOLOGICAL CHEMISTRY  281-  (25)  17492  -17500  2006/06
• Antitumor activity of ZSTK474, a new phosphatidylitiositol 3-kinase inhibitor

  Shin-ichi Yaguchi; Yasuhisa Fukui; Khiro Koshimizu; Hisashi Yoshimi; Toshiyuki Matsuno; Hiroaki Gouda; Shuichi Hirono; Kanaini Yamazaki; Takao Yamori  JOURNAL OF THE NATIONAL CANCER INSTITUTE  98-  (8)  545  -556  2006/04
• Modification of pyrimidine derivatives from antiviral agents to antitumor agents.

  Kimura H; Katoh T; Kajimoto T; Node M; Hisaki M; Sugimoto Y; Majima T; Uehara Y; Yamori T  Anticancer Res  26-  (1A)  91  -7  2006
• Antitumor effect of cotylenin A plus interferon-alpha: Possible therapeutic agents against ovary carcinoma

  Y Honma; T Kasukabe; T Yamori; N Kato; T Sassa  GYNECOLOGIC ONCOLOGY  99-  (3)  680  -688  2005/12
• Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B

  M Yanagihara; N Sasaki-Takahashi; T Sugahara; S Yamamoto; M Shinomi; L Yamashita; M Hayashida; B Yamanoha; A Numata; T Yamori; T Andoh  CANCER SCIENCE  96-  (11)  816  -824  2005/11
• Total synthesis of murisolins and evaluation of tumor-growth inhibitory activity

  Naoyoshi Maezaki; Hiroaki Tominaga; Naoto Kojima; Minori Yanai; Daisuke Urabe; Risa Ueki; Tetsuaki Tanaka; Takao Yamori  Chemistry - A European Journal  11-  (21)  6237  -6245  2005/10
• Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays

  N Nakatsu; Y Yoshida; K Yamazaki; T Nakamura; SG Dan; Y Fukui; T Yamori  MOLECULAR CANCER THERAPEUTICS  4-  (3)  399  -412  2005/03
• p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

  Mashima T; Oh-hara T; Sato S; Mochizuki M; Sugimoto Y; Yamazaki K; Hamada J; Tada M; Moriuchi T; Ishikawa Y; Kato Y; Tomoda H; Yamori T; Tsuruo T  J Natl Cancer Inst  97-  (10)  765  -77  2005
• Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner.

  Guleng B; Tateishi K; Ohta M; Kanai F; Jazag A; Ijichi H; Tanaka Y; Washida M; Morikane K; Fukushima Y; Yamori T; Tsuruo T; Kawabe T; Miyagishi M; Taira K; Sata M; Omata M  Cancer Res  65-  (13)  5864  -71  2005
• New bisindole alkaloids isolated from Myxomycetes Arcyria cinerea and Lycogala epidendrum.

  Kamata K; Kiyota M; Naoe A; Nakatani S; Yamamoto Y; Hayashi M; Komiyama K; Yamori T; Ishibashi M  Chem Pharm Bull (Tokyo)  53-  (5)  594  -7  2005
• Synthesis and biological relationships of 3 ',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents

  YY Lai; LJ Huang; KH Lee; ZY Xiao; KF Bastow; T Yamori; SC Kuo  BIOORGANIC & MEDICINAL CHEMISTRY  13-  (1)  265  -275  2005/01
• Selective sensitivity to wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate of human breast cancer and melanoma cell lines studied in vitro

  T Nomura; S Shinoda; T Yamori; S Sawaki; Nagata, I; K Ryoyama; Y Fuke  CANCER DETECTION AND PREVENTION  29-  (2)  155  -160  2005
• YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis - I. Fermentation, isolation and biological activities

  KY Sohda; K Nagai; T Yamori; KI Suzuki; A Tanaka  JOURNAL OF ANTIBIOTICS  58-  (1)  27  -31  2005/01
• Nucleotide sequence variation is frequent in the mitochondrial DNA displacement loop region of individual human tumor cells

  H Yoneyama; T Hara; Y Kato; T Yamori; ET Matsuura; K Koike  MOLECULAR CANCER RESEARCH  3-  (1)  14  -20  2005/01
• Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

  A Komuro; T Imamura; M Saitoh; Y Yoshida; T Yamori; K Miyazono; K Miyazawa  ONCOGENE  23-  (41)  6914  -6923  2004/09
• Triterpene saponins from the roots of Clematis chinensis

  Y Mimaki; A Yokosuka; M Hamanaka; C Sakuma; T Yamori; Y Sashida  JOURNAL OF NATURAL PRODUCTS  67-  (9)  1511  -1516  2004/09
• Effect on tumor cells of blocking survival response to glucose deprivation

  HR Park; A Tomida; S Sato; Y Tsukumo; J Yun; T Yamori; Y Hayakawa; T Tsuruo; K Shin-Ya  JOURNAL OF THE NATIONAL CANCER INSTITUTE  96-  (17)  1300  -1310  2004/09
• New cytotoxic oleanane-type triterpenoids from the cones of Liquidamber styraciflua

  K Sakai; Y Fukuda; S Matsunaga; R Tanaka; T Yamori  JOURNAL OF NATURAL PRODUCTS  67-  (7)  1088  -1093  2004/07
• Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA(1)

  K Hama; J Aoki; M Fukaya; Y Kishi; T Sakai; R Suzuki  JOURNAL OF BIOLOGICAL CHEMISTRY  279-  (17)  17634  -17639  2004/04
• Pladienolides, new substances from culture of Streptomyces platensis Mer-11107 III. In vitro and In vivo antitumor activities

  Y Mizui; T Sakai; M Iwata; T Uenaka; K Okamoto; H Shimizu; T Yamori; K Yoshimatsu; M Asada  JOURNAL OF ANTIBIOTICS  57-  (3)  188  -196  2004/03
• Csk defines the ability of integrin-mediated cell adhesion and migration in human colon cancer cells: implication for a potential role in cancer metastasis.

  William Rengifo-Cam; Akio Konishi; Naoki Morishita; Hidetada Matsuoka; Takao Yamori; Shigeyuki Nada; Masato Okada  Oncogene  23-  (1)  289  -97  2004/01
• Production of biologically active taxoids by a callus culture of Taxus cuspidata

  J Bai; M Kitabatake; K Toyoizumi; LW Fu; SJ Zhang; JG Dai; J Sakai; K Hirose; T Yamori; A Tomida; T Tsuruo; M Ando  JOURNAL OF NATURAL PRODUCTS  67-  (1)  58  -63  2004/01
• Synthesis of functional proteins by mixing peptide motifs.

  Saito H; Honma T; Minamisawa T; Yamazaki K; Noda T; Yamori T; Shiba K  Chem Biol  11-  (6)  766  -73  2004
• Spiromarienols A and B: two new 7(8 -> 9)abeo- lanostane-type triterpene lactones from the stem bark of Abies mariesii.

  Tanaka R; Wada S; Aoki H; Matsunaga S; Yamori T  Helvetica Chemica Acta  87-  (1)  240  -9  2004
• Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines

  S Dan; M Shirakawa; Y Mukai; Y Yoshida; K Yamazaki; T Kawaguchi; M Matsuura; Y Nakamura; T Yamori  CANCER SCIENCE  94-  (12)  1074  -1082  2003/12
• Antibacterial and antiproliferative activity of cationic fullerene derivatives

  T Mashino; D Nishikawa; K Takahashi; N Usui; T Yamori; M Seki; T Endo; M Mochizuki  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  13-  (24)  4395  -4397  2003/12
• A large-scale gene expression comparison of microdissected, small-sized endometrial cancers with or without hyperplasia matched to same-patient normal tissue.

  Yuko Sugiyama; Shingo Dan; Yoko Yoshida; Futoshi Akiyama; Kazuo Sugiyama; Yasuo Hirai; Masaaki Matsuura; Satoshi Miyata; Masaru Ushijima; Katsuhiko Hasumi; Takao Yamori  Clinical cancer research : an official journal of the American Association for Cancer Research  9-  (15)  5589  -600  2003/11
• Rapid discovery and identification of a tissue-specific tumor biomarker from 39 human cancer cell lines using the SELDI ProteinChip platform

  M Shiwa; Y Nishimura; R Wakatabe; A Fukawa; H Arikuni; H Ota; Y Kato; T Yamori  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  309-  (1)  18  -25  2003/09
• Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides

  T Bando; H Iida; ZF Tao; A Narita; N Fukuda; T Yamori; H Sugiyama  CHEMISTRY & BIOLOGY  10-  (8)  751  -758  2003/08
• Inhibition of DNA topoisomerases I and II, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide

  K Umemura; K Yanase; M Suzuki; K Okutani; T Yamori; T Andoh  BIOCHEMICAL PHARMACOLOGY  66-  (3)  481  -487  2003/08
• Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics.

  Yamori T  Cancer Chemother Pharmacol  52-  (1)  74  -9  2003
• Development of new topoisomerase II-targeting compounds as candidate anticancer drugs.

  Andoh T; Umemura K; Yanase K; Yamori T  New York: Kluwer Academic/ Plenum Publishers; 2003  2003
• Structural revision of sulfated polysaccharide B-1 isolated from a marine Pseudomonas species and its cytotoxic activity against human cancer cell lines

  M Matsuda; T Yamori; M Naitoh; K Okutani  MARINE BIOTECHNOLOGY  5-  (1)  13  -19  2003/01
• Isolation of Peridinin-Related Norcarotenoids with Cell Growth-Inhibitory Activity from the Cultured Dinoflagellate of Symbiodinium sp., a Symbiont of the Okinawan Soft Coral Clavularia viridis, and Analysis of Fatty Acids of the Dinoflagellate.

  Suzuki M; Watanabe K; Fujiwara S; Kurasawa T; Wakabayashi T; Tsuzuki M; Iguchi K; Yamori T  Chem Pharm Bull (Tokyo)  51-  (6)  724  -7  2003
• Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines.

  Tanabe M; Izumi H; Ise T; Higuchi S; Yamori T; Yasumoto K; Kohno K  Cancer Res  63-  (24)  8592  -5  2003
• Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.

  Yang L; Mashima T; Sato S; Mochizuki M; Sakamoto H; Yamori T; Oh-Hara T; Tsuruo T  Cancer Res  63-  (4)  831  -7  2003
• New marine diterpenoids from the Okinawan soft coral Clavularia koellikeri

  M Iwashima; Y Matsumoto; Y Takenaka; K Iguchi; T Yamori  JOURNAL OF NATURAL PRODUCTS  65-  (10)  1441  -1446  2002/10
• Array-based structure and gene expression relationship study of antitumor Sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide

  T Owa; A Yokoi; K Yamazaki; K Yoshimatsu; T Yamori; T Nagasu  JOURNAL OF MEDICINAL CHEMISTRY  45-  (22)  4913  -4922  2002/10
• Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin

  T Sasaki; K Yamazaki; T Yamori; T Endo  BRITISH JOURNAL OF CANCER  87-  (8)  918  -923  2002/10
• Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

  M Umezu-Goto; Y Kishi; A Taira; K Hama; N Dohmae; K Takio; T Yamori; GB Mills; K Inoue; J Aoki; H Arai  JOURNAL OF CELL BIOLOGY  158-  (2)  227  -233  2002/07
• Screening with COMPARE analysis for telomerase inhibitors.

  Naasani I; Yamori T; Tsuruo T  Methods Mol Biol  191-  197  -207  2002
• An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines.

  Dan S; Tsunoda, T; Kitahara, O; Yanagawa, R; Zembutsu; H. Katagiri, T; Yamazaki ,K; Nakamura, Y; Yamori. T  Cancer Research  62-  1139  -47  2002
• -Hydroxyisovalerylshikonin Is a Novel and Potent Inhibitor of ProteinTyrosine Kinases.

  Hashimoto S; Xu Y; Masuda Y; Aiuchi T; Nakajo S; Uehara Y; Shibuya M; Yamori T; Nakaya K  Jpn J Cancer Res  93-  (8)  944  -51  2002
• New Dolabellane-Type Diterpenoids from the Okinawan Soft Coral of the Genus Clavularia.

  Iguchi K; Sawai H; Nishimura H; Fujita M; Yamori T  Bull Chem Soc Jpn  75-  (1)  131  -6  2002
• Development of cDNA microarray for expression profiling of estrogen-responsive genes.

  Inoue A; Yoshida N; Omoto Y; Oguchi S; Yamori T; Kiyama R; Hayashi S  J Mol Endocrinol  29-  (2)  175  -92  2002
• New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus axinyssa.

  Iwashima M; Terada I; Iguchi K; Yamori T  Chem Pharm Bull (Tokyo)  50-  (9)  1286  -9  2002
• Reduced sialidase expression in highly metastatic variants of mouse colon adenocarcinoma 26 and retardation of their metastatic ability by sialidase overexpression

  M Sawada; S Moriya; S Saito; R Shineha; S Satomi; T Yamori; T Tsuruo; R Kannagi; T Miyagi  INTERNATIONAL JOURNAL OF CANCER  97-  (2)  180  -185  2002/01
• Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group.

  Uesato S; Kitagawa M; Nagaoka Y; Maeda T; Kuwajima H; Yamori T  Bioorg Med Chem Lett  12-  (10)  1347  -9  2002
• Inhibition of DNA topoisomerases II and/or I by pyrazolo[1,5-a]indole derivatives and their growth inhibitory activities.

  Umemura K; Mizushima T; Katayama H; Kiryu Y; Yamori T; Andoh T  Mol Pharmacol  62-  (4)  873  -80  2002
• Leptosins M-N-1, cytotoxic metabolites from a Leptosphaeria species separated from a marine alga. Structure determination and biological activities

  T Yamada; C Iwamoto; N Yamagaki; T Yamanouchi; K Minoura; T Yamori; Y Uehara; T Andoh; K Umemura; A Numata  TETRAHEDRON  58-  (3)  479  -487  2002/01
• In vitro cytotoxicity of the protoberberine-type alkaloids

  K Iwasa; M Moriyasu; T Yamori; T Turuo; DU Lee; W Wiegrebe  JOURNAL OF NATURAL PRODUCTS  64-  (7)  896  -898  2001/07
• Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers

  Y Omoto; Y Kobayashi; K Nishida; E Tsuchiya; H Eguchi; K Nakagawa; Y Ishikawa; T Yamori; H Iwase; Y Fujii; M Warner; JA Gustafsson; S Hayashi  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  285-  (2)  340  -347  2001/07
• In vitro cytotoxicity of the protoberberine-type alkaloids

  K Iwasa; M Moriyasu; T Yamori; T Turuo; DU Lee; W Wiegrebe  JOURNAL OF NATURAL PRODUCTS  64-  (7)  896  -898  2001/07
• Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers

  Y Omoto; Y Kobayashi; K Nishida; E Tsuchiya; H Eguchi; K Nakagawa; Y Ishikawa; T Yamori; H Iwase; Y Fujii; M Warner; JA Gustafsson; S Hayashi  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  285-  (2)  340  -347  2001/07
• Antitumor activity, optimum administration method and pharmacokinetics of 13,14-dihydro-15-deoxy-Delta(7)-prostaglandin A(1) methyl ester (TEI-9826) integrated in lipid microspheres (Lipo TEI-9826)

  S Fukushima; Y Takeuchi; S Kishimoto; S Yamashita; K Uetsuki; S Shirakawa; M Suzuki; K Furuta; R Noyori; H Sasaki; Y Kikuchi; T Kita; T Yamori; J Sawada; M Kojima; A Hazato; S Kurozumi; M Fukushima  ANTI-CANCER DRUGS  12-  (3)  221  -234  2001/03
• An efficient and expeditious synthesis of a novel 5H-naphth[1',2': 5,6][1,4]oxazino[2,3-b]quinoxalin-5-one and its unique inhibitory activity against a panel of human cancer cell lines

  F Miyata; S Yoshida; T Yamori; T Katoh  HETEROCYCLES  54-  (2)  619  -+  2001/02
• Repression of cyclin B1 expression after treatment with adriamycin, but not cisplatin in human lung cancer A549 cells

  S Dan; T Yamori  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  280-  (3)  861  -867  2001/01
• Selective activation of apoptosis program by s-p-bromobenzylglutathione cyclopentyl diester in glyoxalase i-overexpressing human lung cancer cells(共著)

  Clin Cancer Res.  7-  2513  -8  2001
• Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity(共著)

  Cancer Res.  61-  4459  -66  2001
• Antitumor activity, optimum administration method and pharmacokinetics of 13,14-dihydro-15-deoxy-delta7-prostaglandin Al methyl ester(TEI-9826)integrated in lipid microspheres(Lipo TEI-9826)(共著)

  Anticancer Drugs.  12-  (221-234)  2001
• An efficient and expeditious synthesis of a novel 5H-naphth[1',2' : 5,6][1,4]oxazino[2,3-b]quinoxalin-5-one and its unique inhibitory activity against a panel of human cancer cell lines(共著)

  Heterocycles.  54-  619  -622  2001
• The Direct Effect of IL-12 on Tumor Cells ; IL-12 Acts Directly on Tumor Cells to Activate NF-kappaB and Enhance IFN-gamma-Mediated STAT1 Phosphorylation(共著)

  Biochem Biophys Res Commun.  280-  (2)  503  -512  2001
• Repression of cyclin B1 expression after treatment with adriamycin, but not cisplatin in human lung cancer A549 cells

  S. Dan; T. Yamori  Biochemical and Biophysical Research Communications  280-  (3)  861  -867  2001
• Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.

  Komatsu Y; Tomizaki KY; Tsukamoto M; Kato T; Nishino N; Sato S; Yamori T; Tsuruo T; Furumai R; Yoshida M; Horinouchi S; Hayashi H  Cancer Res.  61-  (11)  4459  -66  2001
• Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma.

  Saji H; Koike M; Yamori T; Saji S; Seiki M; Matsushima K; Toi M  Cancer  92-  (5)  1085  -91  2001
• Selective activation of apoptosis program by s-p-bromobenzylglutathione cyclopentyl diester in glyoxalase i-overexpressing human lung cancer cells.

  Sakamoto H; Mashima T; Sato S; Hashimoto Y; Yamori T; Tsuruo T  Clin Cancer Res  7-  (8)  2513  -8  2001
• The Direct Effect of IL-12 on Tumor Cells: IL-12 Acts Directly on Tumor Cells to Activate NF-kappaB and Enhance IFN-gamma-Mediated STAT1 Phosphorylation.

  Su W; Ito T; Oyama T; Kitagawa T; Yamori T; Fujiwara H; Matsuda H  Biochem Biophys Res Commun  280-  (2)  503  -12  2001
• Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis

  T Oyama; Y Miyoshi; K Koyama; H Nakagawa; T Yamori; T Ito; H Matsuda; H Arakawa; Y Nakamura  GENES CHROMOSOMES & CANCER  29-  (1)  9  -15  2000/09
• Galtonioside A, a novel cytotoxic cholestane glycoside from Galtonia candicans

  Minpei Kuroda; Yoshihiro Mimaki; Yutaka Sashida; Takao Yamori; Takashi Tsuruo  Tetrahedron Letters  41-  (2)  251  -255  2000/01
• Galtonioside A, a novel cytotoxic cholestane glycoside from Galtonia candicans

  Minpei Kuroda; Yoshihiro Mimaki; Yutaka Sashida; Takao Yamori; Takashi Tsuruo  Tetrahedron Letters  41-  (2)  251  -255  2000/01
• Candicanoside A, a Novel Cytotoxic Rearranged Cholestane Glycoside from ┣DB Galtonia candicans (/)-┫DB(共著)

  Helvetica Chimica Acta.  83-  (10)  2698  -2704  2000
• Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase (]G0001[)(共著)

  Biol Pharm Bull.  23-  (9)  1036  -1040  2000
• Anti-tumor effect of N-beta-alanyl-5-S-glutathionyldihydroxyphenylalanine(5-S-GAD), a novel anti-bacterial substance from an insect(共著)

  Anticancer Res.  20-  357  -62  2000
• Anticancer and Some Biological Activities of Thiazinotrienomycin B(共著)

  J Antibiot.  53-  (3)  306  -308  2000
• Anti-tumor effect of N-beta-alanyl-5-S-glutathionyldihydroxyphenylalanine (5-S-GAD), a novel anti-bacterial substance from an insect.

  Akiyama N; Hijikata M; Kobayashi A; Yamori T; Tsuruo T; Natori S  Anticancer Res  20-  (1a)  57  -62  2000
• Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I

  Egawa K; Yamori T; Nosaka C; Kunimoto S; Takeuchi T; Nos K  Biol Pharm Bull  23-  (9)  1036  -40  2000
• Anticancer and Some Biological Activities of Thiazinotrienomycin B

  Hosokawa N; Iinuma H; Takeuchi T; Sato S; Yamori T; Tsuchiya SK; Hori M  J Antibiot  53-  306  -8  2000
• Candicanoside A,a Novel Cytotoxic Rearranged Cholestane Glycoside from Galtonia candicans.

  Mimaki Y; Kuroda M; Sashiba Y; Yamori T; Tsuruo T  Helv Chim Acta  83-  (1)  2698  -704  2000
• Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel.

  Yamori T; Matsunaga A; Sato S; Yamazaki K; Komi A; Ishizu K; Mita I; Edatsugi H; Matsuba Y; Takezawa K; Nakanishi O; Kohno H; Nakajima Y; Komatsu H; Andoh T; Tsuruo T  Cancer Res  59-  (16)  4042  -9  1999
• Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors(共著)

  Oncogene.  18-  (3)  813  -822  1999
• FJ5002 : a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis(共著)

  Cancer Res.  59-  4004  -11  1999
• Furanonaphthoquinone analogs possessing preferential antitumor activity compared to normal cells(共著)

  Cancer Detect Prev.  23-  539  -50  1999
• Structure-activity relationships of quaternary protoberberine alkaloids having an antimalarial activity(共著)

  Eur J Med Chem.  34-  (12)  1077  -1083  1999
• A human IAP-family gene, apollon, expressed in human brain cancer cells(共著)

  Biochem Biophys Res Commun.  264-  (3)  847  -854  1999
• Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel(共著)

  Cancer Res.  59-  4042  -9  1999
• A human IAP-family gene, apollon, expressed in human brain cancer cells.

  Chen Z; Naito M; Hori S; Mashima T; Yamori T; Tsuruo T  Biochem Biophys Res Commun  264-  (3)  847  -54  1999
• Furanonaphthoquinone analogs possessing preferential antitumor activity compared to normal cells.

  Hirai KI; Koyama J; Pan J; Simamura E; Shimada H; Yamori T; Sato S; Tagahara K; Tsuruo T  Cancer Detect Prev  23-  (6)  539  -50  1999
• Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors.

  Hoshino R; Chatani Y; Yamori T; Tsuruo T; Oka H; Yoshida O; Shimada Y; Ari-i S; Wada H; Fujimoto J; Kohno M  Oncogene  18-  (3)  813  -22  1999
• Structure-activity relationships of quaternary protoberberine alkaloids having an antimalarial activity.

  Iwasa K; Nishiyama Y; Ichimura M; Moriyasu M; Kim H-S; Wataya Y; Yamori T; Tsuruo T; Lee D-U  Eur J Med Chem  34-  1077  -83  1999
• Up-regulation of p27Kip1 correlates inversely with anchorage-independent growth of human cancer cell lines(共著)

  Jpn J Cancer Res.  89-  110  -5  1998
• Up-regulation of p27Kip1 correlates inversely with anchorage- independent growth of human cancer cell lines.

  Kawada M; Uehara Y; Mizuno S; Yamori T; Tsuruo T  Jpn J Cancer Res  89-  (2)  110  -5  1998
• Isolation of murine and human homologues of the fission-yeast dis3(+) gene encoding a mitotic-control protein and its overexpression in cancer cells with progressive phenotype

  JT Lim; T Kuroki; K Ozaki; H Kohsaki; T Yamori; T Tsuruo; S Nakamori; S Imaoka; M Endo; Y Nakamura  CANCER RESEARCH  57-  (5)  921  -925  1997/03
• Anti-tumor efficacy of paclitaxel against human lung cancer xenografts.

  Yamori T; Sato S; Chikazawa H; Kadota T  Jpn J Cancer Res  88-  (12)  1205  -10  1997
• Novel antitumor metabolites produced by a fungal strain form a Sea Hare(共著)

  Tetrahedron Letters.  38-  (47)  8215  -8218  1997
• Anti-tumor efficacy of paclitaxel against human lung cancer xenografts(共著)

  Jpn. J. Cancer Res.  88-  1205  -1210  1997
• Isolation of a novel gene showing reduced expression in metastatic colorectal carcinoma cell lines and cacinomas(共著)

  Jpn. J. Cancer Res.  88-  725  -731  1997
• Isolation of a novel gene showing reduced expression in metastatic colorectal carcinoma cell lines and cacinomas.

  Fukuda S; Kuroki T; Kohsaki H; Hayashi S; Ozaki K; Yamori T; Tsuruo T; Nakamori S; Imaoka S; Nakamura Y  Jpn J Cancer Res  88-  725  -31  1997
• Isolation of murine and human homologues of the fission-yeast dis3+ gene encoding a mitotic-control protein and its overexpression in cancer cells with progressive phenotype.

  Lim J; Kuroki T; Ozaki K; Kohsaki H; Yamori T; Tsuruo T; Nakamori S; Imaoka S; Endo M; Nakamura Y  Cancer Res  57-  (5)  921  -5  1997
• Novel antitumor metabolites produced by a fungal strain from a Sea Hare.

  Numata A; Iritani M; Yamada T; Minoura K; Matsumura E; Yamori T; Tsuruo T  Tetrahedron Lett  38-  (47)  8215  -8  1997
• Expression of carbohydrate-binding protein p33/41 in human tumor cell lines

  A Satoh; E Takayama; K Kojima; H Ogawa; T Yamori; S Sato; T Kawaguchi; T Tsuruo; Y Katsura; T Kina; Matsumoto, I  JOURNAL OF BIOCHEMISTRY  119-  (2)  346  -353  1996/02
• Establihment of a hepatocyte cell line producing growth-promoting factors for liver-colonizing tumor cells.

  Yamori T; Shimada K; Kanda H; Nishizuru Y; Komi A; Yamazaki K; Asanoma K; Ogawa M; Nomura K; Nemoto N; Kumada K; Tsuruo T  Jpn J Caner Res  87-  146  -52  1996
• Establihment of a hepatocyte cell line producing growth-promoting factors for liver-colonizing tumor cells(共著)

  Jpn. J. Caner Res.  87-  146  -152  1996
• Identification of interleukin-6 as a factor that induces neurite outgrowth by PC12 cells primed with NGF(共著)

  J Biochem.  120-  865  -868  1996
• A novel differentiation factor for PC cells from culture supernatant of mouse hepatocyte cell line MLE-15A2(共著)

  Sayoko IHARA; Tohru NISHIKAWA; Koutarou KIMURA; Toshihide FUJIYOSHI; Toshiyuki SHIRAI; Akiko KOMI; Hiroaki KANDA; Takao YAMORI; Yasuhisa FUKUI  Biosci. Biotech. Biochem.  60-  (8)  1339  -1345  1996
• Identification of interleukin-6 as a factor that induces neurite outgrowth by PC12 cells primed with NGF.

  Ihara S; Iwamatsu A; Fujiyoshi T; Komi A; Yamori T; Fukui Y  J Biochem  120-  (5)  865  -8  1996
• A novel differentiation factor for PC cells from culture supernatant of mouse hepatocyte cell line MLE-15A2.

  Ihara S; Nishikawa T; Kimura K; Fujiyoshi T; Shirai T; Komi A; Kanda H; Yamori T; Fukui Y  Biosci Biotech Biochem  60-  (8)  1339  -45  1996
• Expression of Carbohydrate-binding protein p33/41 human tumor cell lines.

  Satoh A; Takayama E; Kojima K; Ogawa H; Yamori T; Sato S; Kawaguchi T; Tsuruo T; Yoshimoto K; Kine T; Matsumoto I  J Biochem  119-  346  -53  1996
• PURIFICATION AND CHARACTERIZATION OF THE PLATELET-AGGREGATING SIALOGLYCOPROTEIN GP44 EXPRESSED BY HIGHLY METASTATIC VARIANT CELLS OF MOUSE COLON ADENOCARCINOMA-26

  M TOYOSHIMA; M NAKAJIMA; T YAMORI; T TSURUO  CANCER RESEARCH  55-  (4)  767  -773  1995/02
• Expression of sulfomucins in normal mucosae, colorectal adenocarcinomas, and metastases(共著)

  Jpn. J. Cancer Res.  86-  1060  -1067  1995
• Histochemical detection of sugar residues by joint of specific antibodies and lectins(共著)

  Hayayo Kawakami; Yoshiakira Kanai; Takao Yamori; Takashi Tsuruo; Hiroshi Hirano  Acta Histochem Cytochem.  28-  (2)  191  -192  1995
• Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of phosphatidylinositol 3-kinase: use of the antibodies in recognition of mutant p85.

  Daduang S; Nagata S; Matsuda M; Yamori T; Onodera K; Fukui Y  Immunol Cell Biol  73-  (2)  134  -9  1995
• Histochemical detection of sugar residues by joint of specific antibodies and lectins.

  Kawakami H; Kanai Y; Yamori T; Tsuruo T; Hirano H  Acta Histochem Cytochem  28-  (2)  191  -2  1995
• Expression of sulfomucins in normal mucosae, colorectal adenocarcinomas, and metastases.

  Matsushita Y; Yamamoto N; Shirahama H; Tanaka S; Yonezawa S; Yamori T; Irimura T; Sato E  Jpn J Cancer Res  86-  1060  -7  1995
• Purification and characterization of the platelet-aggregating sialoglycoprotein gp44 expressed by highly metastatic variant cells of mouse colon adenocarcinoma 26.

  Toyoshima M; Nakajima M; Yamori T; Tsuruo T  Cancer Res  55-  (4)  767  -73  1995
• EVALUATION OF ANTITUMOR-ACTIVITY OF NAVELBINE (VINORELBINE DITARTRATE) AGAINST HUMAN BREAST-CARCINOMA XENOGRAFTS BASED ON ITS PHARMACOKINETICS IN NUDE-MICE

  T TSURUO; M INABA; T TASHIRO; T YAMORI; Y OHNISHI; T ASHIZAWA; T SAKAI; S KOBAYASHI; K GOMI  ANTI-CANCER DRUGS  5-  (6)  634  -640  1994/12
• EXPRESSION OF INSULIN-RECEPTOR SUBSTRATE-1 IN HEPATOCYTES - AN INVESTIGATION USING MONOCLONAL-ANTIBODIES

  A FURUSAKA; M NISHIYAMA; K OHKAWA; T YAMORI; T TSURUO; K YONEZAWA; M KASUGA; SI HAYASHI; T TANAKA  CANCER LETTERS  84-  (1)  85  -92  1994/08
• INHIBITORY EFFECTS OF TUMOR INVASION-INHIBITING FACTOR-2 AND ITS CONJUGATE ON DISSEMINATING TUMOR-CELLS

  A ISOAI; H GOTOTSUKAMOTO; T YAMORI; T OHHARA; T TSURUO; S SILLETTI; A RAZ; H WATANABE; H AKEDO; H KUMAGAI  CANCER RESEARCH  54-  (5)  1264  -1270  1994/03
• Production of monoclonal antibodies specific to the carboxyl terminal region of the 85kDa subunit of phosphatidylinositol 3-kinase ; Use of the antibodies in recognition of mutant p85(共著)

  Immunol. Cell Biol.  73-  1  -6  1994
• Inhibitory effects of tumor invasion-inhibiting factor 2 and its conjugate on disseminating tumor cells.

  Isoai A; Goto-Tsukamoto H; Yamori T; Oh-hara T; Tsuruo T; Silletti S; Raz A; Watanabe H; Akedo H; Kumagai H  Cancer Res  54-  1264  -70  1994
• Evaluation of antitumor activity of navelbine (vinorelbine ditartrate) against human breast carcinoma xenografts based on its pharmacokinetics in nude mice.

  Tsuruo T; Inaba M; Tashiro T; Yamori T; Ohnishi Y; Ashizawa T; Sakai T; Kobayashi S; Gomi K  Anticancer Drugs  5-  634  -40  1994
• Identification of HS1 protein as major substrate of protein-tyrosine kinase(s)upon B-cell antigen receptor-mediated signaling(共著)

  Proc. Natl. Acad. Sci. USA.  90-  (8)  3631  -3635  1993
• Control of Apoptosis and Growth of Malignant T Lymphoma Cells by Lymph Node Stromal Cell, Exp.(共著)

  Cell Res.  207-  (2)  271  -276  1993
• Control of Apoptosis and Growth of Malignant T Lymphoma Cells by Lymph Node Stromal Cell.

  Kataoka S; Naito M; Fujita N; Ishii H; Ishii S; Yamori T; Nakajima M; Tsuruo T  Exp Cell Res  207-  271  -6  1993
• Identification of HS1 protein as major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.

  Yamanashi Y; Okada, M; Semba, T; Yamori T; Umemori, H; Tsunasawa, S; Toyoshima, K; Kitamura, D; Watanabe, T; Yamamoto, T  Proc Natl Acad Sci USA  90-  3631  -5  1993
• Anticancer activities of orally administered menogaril against human stomach and breast cancers implanted in mude mice(共著)

  Anticancer Res.  12-  1953  -1956  1992
• Anticancer activities of orally administered menogaril against human stomach and breast cancers implanted in mude mice.

  Inaba M; Sato S; Yamori T; Tashiro T; Ohnishi Y; Maruo K; Ueyama Y; Tsuruo T  Anticancer Res  12-  1953  -6  1992
• FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis.

  Naasani I; Seimiya H; Yamori T; Tsuruo T  Cancer Res  59-  (16)  4004  -11  1991
• Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metstatic mouse colon carcinoma 26 NL-17 cells.

  Yamori T; Iizuka Y; Takayama Y; Nishiya S; Iwashita S; Yamazaki A; Takatori T; Tsuruo T  Cancer Res  51-  5859  -65  1991
• Ectopic expression of mucins in colorectal cancer metastasis(共著)

  Semin Cancer Biol.  2-  129  -39  1991
• Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metstatic mouse colon carcinoma 16 NL-17 cells(共著)

  Cancer Res.  51-  5859  -5865  1991
• Ectopic expression of mucins in colorectal cancer metastasis.

  Irimura T; Matsushita Y; Hoff SD; Yamori T; Nakamori S; Frazier ML; Giacco GG; Cleary KR; Ota DM  Semin Cancer Biol  2-  (2)  129  -39  1991
• Inhibition of lung colonization of mouse colon 26 adenocarcinoma by recombinant mouse interferon b through a modification of platelet function.(共著)

  Clin. Expl. Metastasis.  8-  203  -213  1990
• Low metastatic potential of clone from murine colon adenocarcinoma 26 increased by transfection of activated c-erB-2 gene(共著)

  J. Natl. Cancer Inst.  82-  1633  -1636  1990
• Inhibition of lung colonization of mouse colon 26 adenocarcinoma by recombinant mouse interferon  through a modification of platelet function.

  Tsuruo T; Saito H; Watanabe M; Sugimoto Y; Yamori T; Oh-hara T  Clin Expl Metastasis  8-  203  -13  1990
• Low metastatic potential of clone from murine colon adenocarcinoma 26 increased by transfection of activated c-erB-2 gene.

  Yusa K; Sugimoto Y; Yamori T; Yamamoto T; Toyoshima K; Tsuruo T  J Natl Cancer Inst.  82-  1633  -6  1990
• MONOCLONAL-ANTIBODY AGAINST HUMAN COLONIC SULFOMUCIN - IMMUNOCHEMICAL DETECTION OF ITS BINDING-SITES IN COLONIC MUCOSA, COLORECTAL PRIMARY-CARCINOMA, AND METASTASES

  T YAMORI; DM OTA; KR CLEARY; S HOFF; LG HAGER; T IRIMURA  CANCER RESEARCH  49-  (4)  887  -894  1989/02
• Monoclonal antibody against human colonic sulfomucin: Immunochemical detection of its binding sites in colonic mucosa, colorectal primary carcinoma, and metastases.

  Yamori T; Ota DM; Cleary KR; Hoff S; Hager LG; Irimura T  Cancer Research  49-  887  -94  1989
• Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma.

  Hoff SD; Matsushita Y; Ota DM; Cleary KR; Yamori T; Hakomori S; Irimura T  Cancer Res  49-  6883  -8  1989
• Insulin and insulin like growth factor (]G0001[) stimulate proliferation of metastatic variants of colon carcinoma 26.(共著)

  Jpn. J. Cancer Res.  80-  51  -58  1989
• Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma(共著)

  Cancer Res.  49-  6883  -8  1989
• Insulin and insulin like growth factor I stimulate proliferation of metastatic variants of colon carcinoma 26.

  Koenuma M; Yamori T; Tsuruo T  Jpn J Cancer Res  80-  51  -8  1989
• DIFFERENTIAL EXPRESSION OF A SIALOGLYCOPROTEIN WITH AN APPROXIMATE MOLECULAR-WEIGHT OF 900,000 ON METASTATIC HUMAN-COLON CARCINOMA-CELLS GROWING IN CULTURE AND IN TUMOR-TISSUES

  T IRIMURA; DA CARLSON; J PRICE; T YAMORI; R GIAVAZZI; DM OTA; KR CLEARY  CANCER RESEARCH  48-  (9)  2353  -2360  1988/05
• INCREASED CONTENT OF CHONDROITIN SULFATE PROTEOGLYCAN IN HUMAN COLORECTAL-CARCINOMA METASTASES COMPARED WITH THE PRIMARY TUMOR AS DETERMINED BY AN ANTI-CHONDROITIN-SULFATE MONOCLONAL-ANTIBODY

  T YAMORI; DM OTA; KR CLEARY; T IRIMURA  JOURNAL OF CELLULAR BIOCHEMISTRY  36-  (4)  405  -416  1988/04
• Growth stimulating activity of lung extract on lung-colonizing colon 26 clones and its partial characterization.

  Yamori T; Iida H; Tsukagoshi S; Tsuruo T  Clin Expl Metastasis  6-  131  -9  1988
• Differential expression of a sialoglycoprotein with an approximate molecular weight of 900,000 on metastatic human colon carcinoma cells growing in culture and in tumor tissues.

  Irimura T; Carlson DA; Yamori T; Giavazzi R; Ota DM; Cleary KR  Cancer Res  48-  2353  -60  1988
• Development of lymphosarcoma lines with high metastatic ability to lymph nodes and visceral organs in BALB/c mice.(共著)

  Clin. Expl. Metastasis.  6-  141  -152  1988
• Increased content of chondroitin sulfate proteoglycan in human colorectal carcinoma metastases compared with the primary tumor as determined by and anti-chondroitin sulfate monoclonal antibody.(共著)

  J. Cellular Biochemistry.  36-  (4)  405  -416  1988
• Growth stimulating activity of lung extract on lung-colonizing colon 26 clones and its partial characterization.(共著)

  Clin. Expl. Metastasis.  6-  131  -139  1988
• Development of lymphosarcoma lines with high metastatic ability to lymph nodes and visceral organs in BALB/c mice.

  Tsuruo T; Ishikawa T; Oh-hara T; Yamori T; Tsukagoshi S; Sugano H  Clin Expl Metastasis  6-  141  -52  1988
• THE RELATIONSHIP OF COLLAGENOLYTIC ACTIVITY TO STAGE OF HUMAN COLORECTAL-CARCINOMA

  T IRIMURA; T YAMORI; SC BENNETT; DM OTA; KR CLEARY  INTERNATIONAL JOURNAL OF CANCER  40-  (1)  24  -31  1987/07
• DIFFERENTIAL PRODUCTION OF HIGH-MOLECULAR-WEIGHT SULFATED GLYCOPROTEINS IN NORMAL COLONIC MUCOSA, PRIMARY COLON-CARCINOMA, AND METASTASES

  T YAMORI; H KIMURA; K STEWART; DM OTA; KR CLEARY; T IRIMURA  CANCER RESEARCH  47-  (10)  2741  -2747  1987/05
• Differential production of high molecular weight sulfated glycoproteins in normal colonic mucosa, primary colon carcinoma, and metastases.

  Yamori T; Kimura H; Stewart K; Ota DM; Cleary KR; Irimura T  Cancer Res  47-  2741  -7  1987
• Glycoconjugates and tumor metastasis. In : A. M. (ed.), Molecular Immunology of Complex Carbohydrates.(共著)

  New York ; Prenum Press  677  -704  1987
• Acquisition of metastatic ability in hybridomas between two low metastatic clones of colon adenocarcinoma 26 defective in either platelet-aggregating activity or in vivo growth potential.(共著)

  Cancer Res.  47-  4396  -4401  1987
• The relationship of collagenolytic activity to stage of human colorectal carcinoma.(共著)

  Int. J. Cancer.  40-  24  -31  1987
• Glycoconjugates and tumor metastasis. In: A. M. Wu (ed.), Molecular Immunology of Complex Carbohydrates.

  Irimura T; Nakajima M; Yamori T; Ota DM; R. CK; Nicolson GL  New York: Prenum Press  677  -704  1987
• Acquisition of metastatic ability in hybridomas between two low metastatic clones of colon adenocarcinoma 26 defective in either platelet-aggregating activity or in vivo growth potential.

  Sugimoto Y; Oh-hara T; Watanabe M; Saito H; Yamori T; Tsuruo T  Cancer Res  47-  4396  -401  1987
• Tumor induced platelet aggregation and growth promoting factors as determinants for successful tumor metastasis.(共著)

  Clin. Expl. Metastasis,  4-  25  -33  1986
• TUMOR-INDUCED PLATELET-AGGREGATION AND GROWTH-PROMOTING FACTORS AS DETERMINANTS FOR SUCCESSFUL TUMOR-METASTASIS

  T TSURUO; H KAWABATA; H IIDA; T YAMORI  CLINICAL & EXPERIMENTAL METASTASIS  4-  (1)  25  -33  1986/01
• INHIBITION OF SPONTANEOUS AND EXPERIMENTAL TUMOR-METASTASIS BY THE CALCIUM-ANTAGONIST VERAPAMIL

  T TSURUO; H IIDA; F MAKISHIMA; T YAMORI; H KAWABATA; S TSUKAGOSHI; Y SAKURAI  CANCER CHEMOTHERAPY AND PHARMACOLOGY  14-  (1)  30  -33  1985
• Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil.

  Tsuruo T; Iida H; Makishima F; Yamori T; Kawabata H; Tsukagoshi S; Sakurai Y  Cancer Chemother Pharmacol  14-  30  -3  1985
• Metastasis after intravenous inoculation of highly metastatic variant of mouse tumors and the effect of several antitumor drugs on the tumors.

  Tsuruo T; Yamori T; Naganuma K; Hori K; Kawabata H; Tsukagoshi S; Sakurai Y  Gann  75-  193  -8  1984
• METASTASIS AFTER INTRAVENOUS INOCULATION OF HIGHLY METASTATIC VARIANTS OF MOUSE-TUMORS AND THE EFFECTS OF SEVERAL ANTITUMOR DRUGS ON THE TUMORS

  T TSURUO; T YAMORI; K NAGANUMA; K HORI; H KAWABATA; S TSUKAGOSHI; Y SAKURAI  GANN  75-  (2)  193  -198  1984
• Spontaneous metastatic variants of mouse tumor and the effect of drugs on the metastasis.(共著)

  Gann.  75-  557  -563  1984
• ISOLATION AND CHARACTERIZATION OF HIGHLY AND RARELY METASTATIC CLONES FROM MURINE COLON ADENOCARCINOMA-26

  T YAMORI; T TSURUO; K NAGANUMA; S TSUKAGOSHI; Y SAKURAI  INVASION & METASTASIS  4-  (2)  84  -97  1984
• Spontaneous metastatic variants of mouse tumor and the effect of drugs on the metastasis.

  Tsuruo T; Naganuma K; Yamori T; Kabawata H; Oh-hara T; Iida H; Tsukagoshi S; Sakurai Y  Gann  75-  557  -63  1984
• CHARACTERIZATION OF METASTATIC CLONES DERIVED FROM A METASTATIC VARIANT OF MOUSE COLON ADENOCARCINOMA-26

  T TSURUO; T YAMORI; K NAGANUMA; S TSUKAGOSHI; Y SAKURAI  CANCER RESEARCH  43-  (11)  5437  -5442  1983
• Characterization of metasttic clones derived from a metastatic variant of mouse colon adnocarcinoma 26.

  Tsuruo T; Yamori T; Naganuma K; Tsukagoshi S; Sakurai Y  Cancer Res  43-  5437  -42  1983
• Inhibition of lymph node metastasis of P388 leukemia by bestatin in mice.

  Tsuruo T; Naganuma K; Iida H; Yamori T; Tsukagoshi S; Sakurai Y  J Antibiot (Tokyo)  34-  (9)  1206  -1209  1981
• Inhibition of lymph node metastasis of P388 leukemia by bestatin in mice.(共著)

  TAKASHI TSURUO; KUNIKO NAGANUMA; HARUMI IIDA; TAKAO YAMORI; SHIGERU TSUKAGOSHI; YOSHIO SAKURAI  J. Antibiot. (Tokyo).  34-  (9)  1206  -1209  1981
• Enhanced cytocidal action of methotrexate by conjugation to concanavalin A.

  Tsuruo T; Yamori T; Tsukagoshi S; Sakurai Y  Int J Cancer  26-  655  -9  1980
• Enhanced cytocidal action fo methotrexate by conjugation to concanavalin A(共著)

  Int. J. Cancer  26-  655  -659  1980
• Antitumor efficacy of aclacinomycin A(共著)

  SHIGERU TSUKAGOSHI; TAKASHI TSURUO; TAKAO YAMORI; HARUMI IIDA; KUNIKO NAGANUMA; YOSHIO SAKURAI  J. Pharmaco-Biodymanics.  3-  (10)  532  -536  1980
• Antitumor efficacy of aclacinomycin A.

  Tsukagoshi S; Tsuruo T; Yamori T; Iida H; Naganuma K; Sakurai Y  J Pharmaco-Biodymanics  3-  532  -6  1980

Awards & Honors

• 2008 財団法人癌研究会学術賞
   

  受賞者: 矢守 隆夫
• 1993 日本癌学会奨励賞
   JPN

Research Grants & Projects

• がん研究分野の特性等を踏まえた支援活動

  科学研究費補助金

  Date (from‐to) : 2010 -2015
• 薬理活性の評価

  科学研究費補助金

  Date (from‐to) : 2010 -2012
• Cancer Cell Informaticsによる革新的分子標的薬の創薬研究

  科学研究費補助金

  Date (from‐to) : 2010 -2012
• 生物情報科学的手法による抗がん剤の分子薬理学研究
• がん転移の分子機構
• 新規抗がん剤の探索と評価
• Study of Molecular Pharmacology of Anticancer Drugs by a Bioinformatic Approach
• Molecular Mechanism of Cancer Metastasis
• Discovery and evaluation of New Anticancer drugs