Kamata Riyo

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Senior Assistant Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201401088213121890

J-Global ID

• 201401088213121890

Research Interests

• がん関連血栓症   乳がん細胞   好中球   がん転移   プロテアーゼ   

Research Areas

• Life sciences / Pharmaceuticals - health and biochemistry

Academic & Professional Experience

• 2020/04 - Today  Teikyo University
• 2008/04 - 2019/03  Teikyo UniversityFaculty of Pharma-Science
• 2006/04 - 2008/03  Teikyo UniversityFaculty of Pharmaceutical SciencesResearch Associate

Association Memberships

• 日本免疫学会   日本癌学会   Society for Leukocyte Biology   THE JAPANESE BIOCHEMICAL SOCIETY   THE PHARMACEUTICAL SOCIETY OF JAPAN   

Research Activity Information

Published Papers

• Tissue Factor Pathway-Driven Initial Thrombin Generation is Associated with Hypercoagulability in Obesity

  Yuichi Kamikubo; Satomi Nagaya; Rina Inoue; Koichi Yamaguchi; Riyo Morimoto-Kamata; Eriko Morishita; Fahumiya Samad; Naoki Ohkura; Kenichi Inoue

  Thrombosis and Haemostasis Georg Thieme Verlag KG 0340-6245 2025/03 [Refereed]
  
• Chemotactic Activity of Products of Elizabethkingia anophelis Derived from Aedes albopictus against RAW264 Murine Macrophage Cell Line.

  Satoru Yui; Norihiko Fujii; Jo Terauchi; Nana Tanabe; Marie Kanno; Kouta Umehara; Ryosuke Iijima; Riyo Kamata; Naoki Ohkura; Seishi Kishimoto; Toshinori Sasaki

  Japanese journal of infectious diseases 78 (1) 35 - 42 2025/01 [Refereed]
  
• Paclitaxel and Vinblastine Increase Plasminogen Activator Inhibitor-1 Production in Human Breast Cancer MCF-7 Cells but Not MDA-MB-231 Cells.

  Riyo Morimoto-Kamata; Naoki Ohkura

  Biological & pharmaceutical bulletin 47 (9) 1494 - 1503 2024 [Refereed]
  
• Antithrombotic Natural Products That Inhibit Plasminogen Activator Inhibitor 1 (PAI-1)

  Naoki Ohkura; Riyo Morimoto-Kamata

  BPB Reports Pharmaceutical Society of Japan 7 (2) 51 - 55 2024 [Refereed]
  
• Hypofibrinolytic phenotype in Tsumura Suzuki Obese Diabetes (TSOD) mice unrelated to hyperglycemia.

  Naoki Ohkura; Riyo Morimoto-Kamata; Yuichi Kamikubo; Yoshihisa Takahashi; Katsutaka Oishi

  Drug discoveries & therapeutics 17 (5) 346 - 350 2023/11 [Refereed]
  
• Supplementation with Ashitaba (Angelica keiskei) Yellow Stem Exudate Prevents Aging-Induced Thrombotic Tendencies and Systemic Inflammation Without Affecting Body Weight Gain in Mice.

  Naoki Ohkura; Riyo Morimoto-Kamata; Katsutaka Oishi; Sayaka Higo-Yamamoto; Aya Fujinami; Ken-Ichi Inoue; Mitsuhiro Ohta

  Journal of medicinal food 26 (11) 843 - 848 2023/11 [Refereed]
  
• Cathepsin G-induced malignant progression of MCF-7 cells involves suppression of PAF signaling through induced expression of PAFAH1B2.

  Kazunari Tanigawa; Mitsuo Kiriya; Yasuhiro Hayashi; Yoshiaki Shinden; Yuko Kijima; Shoji Natsugoe; Takahiro Sumimoto; Riyo Morimoto-Kamata; Satoru Yui; Kotaro Hama; Kazuaki Yokoyama; Yasuhiro Nakamura; Koichi Suzuki; Hisao Nojiri; Keizo Inoue; Ken Karasawa

  Biochimica et biophysica acta. Molecular and cell biology of lipids 1867 (8) 159164 - 159164 2022/04 [Refereed]
  
• Cathepsin G-Induced Cell Aggregation of Breast Cancer MCF-7 Decreases Doxorubicin Sensitivity in a Hypoxia-Inducible Factor-Independent Mechanism.

  Riyo Morimoto-Kamata; Shun Matsuki; Naoki Ohkura; Satoru Yui

  Biological & pharmaceutical bulletin 45 (12) 1772 - 1783 2022 [Refereed]
  
• Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1.

  Riyo Morimoto-Kamata; Daiki Tsuji; Satoru Yui

  Biological & pharmaceutical bulletin 43 (11) 1678 - 1686 2020 [Refereed]
  
• Breast cancer cell aggregation and metastasis induced by neutrophil

  鎌田理代; 油井聡

  細胞 50 (663) 34 - 37 2018/04 [Invited]
  
• Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells.

  Morimoto-Kamata R; Yui S

  Cancer Sci. 108 (8) 1574 - 1583 1347-9032 2017/08 [Refereed]
  
• Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

  Yoshihiro Akimoto; Mary Miyaji; Riyo Morimoto-Kamata; Yasuhiro Kosaka; Akiko Obinata

  Journal of Developmental Biology MDPI AG 2 (3) 158 - 173 2014/06 [Refereed]
  
• Neutrophil Cathepsin G, but Not Elastase, Induces Aggregation of MCF-7 Mammary Carcinoma Cells by a Protease Activity-Dependent Cell-Oriented Mechanism

  Satoru Yui; Yuuki Osawa; Takeo Ichisugi; Riyo Morimoto-Kamata

  MEDIATORS OF INFLAMMATION 2014 971409  0962-9351 2014 [Refereed]
  
• Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation

  Riyo Morimoto-Kamata; Sei-ichiro Mizoguchi; Takeo Ichisugi; Satoru Yui

  MEDIATORS OF INFLAMMATION 2012 456462  0962-9351 2012 [Refereed]
  
• Overexpression of Hematopoietically Expressed Homeoprotein Induces Nonapoptotic Cell Death in Mouse Prechondrogenic ATDC5 Cells

  Riyo Morimoto; Akiko Obinata

  BIOLOGICAL & PHARMACEUTICAL BULLETIN 34 (10) 1589 - 1595 0918-6158 2011/10 [Refereed]
  
• Functional Characterization of Rat Plasma Membrane Monoamine Transporter in the Blood-Brain and Blood-Cerebrospinal Fluid Barriers

  Takashi Okura; Sayaka Kato; Yusuke Takano; Takenori Sato; Atsushi Yamashita; Riyo Morimoto; Sumio Ohtsuki; Tetsuya Terasaki; Yoshiharu Deguchi

  JOURNAL OF PHARMACEUTICAL SCIENCES 100 (9) 3924 - 3938 0022-3549 2011/09 [Refereed]
  
• Homeoprotein Hex is expressed in mouse developing chondrocytes

  Riyo Morimoto; Akitsugu Yamamoto; Yoshihiro Akimoto; Akiko Obinata

  JOURNAL OF BIOCHEMISTRY 150 (1) 61 - 71 0021-924X 2011/07 [Refereed]
  
• Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium

  Akiko Obinata; Keitarou Osakabe; Mari Yamaguchi; Riyo Morimoto; Yoshihiro Akimoto

  INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 55 (10-12) 933 - 943 0214-6282 2011 [Refereed]
  
• Secretion of L-glutamate from osteoclasts through transcytosis

  Riyo Morimoto; Shunsuke Uehara; Shouki Yatsushiro; Narinobu Juge; Zhaolin Hua; Shigenori Senoh; Noriko Echigo; Mitsuko Hayashi; Toshihide Mizoguchi; Tadashi Ninomiya; Nobuyuki Udagawa; Hiroshi Omote; Akitsugu Yamamoto; Robert H. Edwards; Yoshinori Moriyama

  EMBO JOURNAL 25 (18) 4175 - 4186 0261-4189 2006/09 [Refereed]
  
• Transmembrane topology of vesicular glutamate transporter 2

  SK Jung; R Morimoto; M Otsuka; H Omote

  BIOLOGICAL & PHARMACEUTICAL BULLETIN 29 (3) 547 - 549 0918-6158 2006/03 [Refereed]
  
• Vesicular storage and secretion of L-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells

  S Uehara; SK Jung; R Morimoto; S Arioka; T Miyaji; N Juge; M Hiasa; K Shimizu; A Ishimura; M Otsuka; A Yamamoto; P Maechler; Y Moriyama

  JOURNAL OF NEUROCHEMISTRY 96 (2) 550 - 560 0022-3042 2006/01 [Refereed]
  
• A human transporter protein that mediates the final excretion step for toxic organic cations

  M Otsuka; T Matsumoto; R Morimoto; S Arioka; H Omote; Y Moriyama

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (50) 17923 - 17928 0027-8424 2005/12 [Refereed]
  
• A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from delta-cells of islets of Langerhans

  A Muroyama; S Uehara; S Yatsushiro; N Echigo; R Morimoto; M Morita; M Hayashi; A Yamamoto; DS Koh; Y Moriyama

  DIABETES 53 (7) 1743 - 1753 0012-1797 2004/07 [Refereed]
  
• Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by alpha-cells of islet of Langerhans

  S Uehara; A Muroyama; N Echigo; R Morimoto; M Otsuka; S Yatsushiro; Y Moriyama

  DIABETES 53 (4) 998 - 1006 0012-1797 2004/04 [Refereed]
  
• Expression and localization of vesicular glutamate transporters in pancreatic islets, upper gastrointestinal tract, and testis

  M Hayashi; R Morimoto; A Yamamoto; Y Moriyama

  JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 51 (10) 1375 - 1390 0022-1554 2003/10 [Refereed]
  
• Vesicular inhibitory amino acid transporter is present in glucagon-containing secretory granules in alpha TC6 cells, mouse clonal alpha-cells, and alpha-cells of islets of Langerhans

  M Hayashi; M Otsuka; R Morimoto; A Muroyama; S Uehara; A Yamamoto; Y Moriyama

  DIABETES 52 (8) 2066 - 2074 0012-1797 2003/08 [Refereed]
  
• Secretory granule-mediated co-secretion of L-glutamate and glucagon triggers glutamatergic signal transmission in Islets of Langerhans

  M Hayashi; H Yamada; S Uehara; R Morimoto; A Muroyama; S Yatsushiro; J Takeda; A Yamamoto; Y Moriyama

  JOURNAL OF BIOLOGICAL CHEMISTRY 278 (3) 1966 - 1974 0021-9258 2003/01 [Refereed]
  
• Co-expression of vesicular glutamate transporters (VGLUT1 and VGLUT2) and their association with synaptic-like microvesicles in rat pinealocytes

  R Morimoto; M Hayashi; S Yatsushiro; M Otsuka; A Yamamoto; Y Moriyama

  JOURNAL OF NEUROCHEMISTRY 84 (2) 382 - 391 0022-3042 2003/01 [Refereed]
  

MISC

• 乳がん細胞4T1移植マウスを用いたがん関連血栓症モデルの構築と血栓症早期検出の検討

  鎌田理代; 神窪勇一; 太田尚希; 宗像理紗; 鈴木亮; 影山彩織; 丸山一雄; 大藏直樹  日本薬学会第145年会要旨集 145nd 2025年3月  2025/03
• 初期のトロンビン産生を高感度に検出する新規凝固試験を用いた肥満における凝固亢進状態の解析

  神窪勇一; 鎌田理代; 井上賢一; 大藏直樹  日本血栓止血学会誌  34-  (2)  2023
• PAI-1 release from breast cancer MCF-7 cells after transient treatment with chemotherapeutic agents

  鎌田理代; 石川詩織; 大川原成美; 大藏直樹  日本薬学会年会要旨集(Web)  143rd-  2023
• Screening for antibiotics that affect blood coagulability

  永久保真由; 小川幸愛; 萩原涼太; 前島多絵; 鎌田理代; 板垣文雄; 飯島亮介; 大藏直樹  日本薬学会年会要旨集(Web)  143rd-  2023
• Effect of cathepsin G on blood coagulation factors production from MCF-7 cells

  中原美樹; 鎌田理代; 金子晃大; 大藏直樹  日本薬学会年会要旨集(Web)  143rd-  2023
• Human breast cancer MCF-7 cell aggregates induced by neutrophil cathepsin G is resistant to doxorubicin via P-glycoprotein-independent mechanism

  Riyo Morimoto-Kamata; Naoki Ohkura; Satoru Yui  日本薬学会年会要旨集(Web)  142nd-  2022/03
• 自然発症2型糖尿病モデルマウス(TSODマウス)における血液凝固線溶系

  大藏直樹; 大石勝隆; 神窪勇一; 鎌田理代  日本血栓止血学会誌  33-  (2)  2022
• Exploration of functional substances in black vinegar moromi extract

  大藏直樹; 鎌田理代; 飯島亮介; 藤井暁; 長野正信; 惠谷晋; 梅井瑞希; 谷口雅彦  日本薬学会年会要旨集(Web)  142nd-  2022
• 黒酢濃縮物および黒酢もろみ末抽出物の食品機能の検討(2)

  大藏直樹; 鎌田理代; 飯島亮介; 藤井暁; 赤瀬智子; 神窪勇一; 長野正信; 谷口雅彦  日本未病学会学術総会抄録集  29th-  2022
• Human breast cancer MCF-7 cell aggregates induced by neutrophil cathepsin G is resistant to doxorubicin via P-glycoprotein-independent mechanism

  Riyo Morimoto-Kamata  第80回 日本癌学会学術総会 要旨集  2021/10
• Molecular mechanism of cathepsin G-induced elevation of insulin-like growth factor-1 in the medium of breast cancer MCF-7

  鎌田理代; 辻大貴; 油井聡  日本薬学会年会要旨集(Web)  141st-  2021
• アシタバ黄汁を長期摂取した高齢マウスは加齢による血栓形成傾向が抑制される

  大藏直樹; 鎌田理代; 大石勝隆; 井上賢一; 谷口雅彦  日本未病学会学術総会抄録集  28th-  2021
• 好中球カテプシンGで誘導したヒト乳がん細胞株MCF-7の細胞凝集体は低酸素誘導因子非依存的メカニズムでドキソルビシン耐性を示す

  鎌田理代; 油井聡  日本癌学会学術総会抄録集(Web)  80th-  2021
• Cathepsin G-induced insulin-like growth factor (IGF) elevation in MCF-7 medium is caused by proteolysis of IGF binding protein (IGFBP)-2 but not that of IGF-1

  Riyo Morimoto-Kamata; Satoru Yui  第79回 日本癌学会学術総会  2020/10
• Mechanism of insulin-like growth factor-1 release by neutrophil cathepsin G in the medium of breast cancer MCF-7 cells

  Riyo Morimoto-Kamata; Daiki Tsuji; Satoru Yui  日本薬学会年会要旨集(Web)  140th-  2020/03
• Cathepsin G-induced insulin-like growth factor elevation in MCF-7 medium is caused by IGF binding protein-2 proteolysis

  鎌田理代; 油井聡  日本癌学会学術総会抄録集(Web)  79th-  2020
• Expression of hypoxia inducible factor and resistant to doxorubicin in cathepsin G-induced breast cancer cell aggregates

  鎌田(森本)理代; 油井聡  日本癌学会学術総会抄録集(Web)  78th-  2019
• カテプシンG誘導乳がん細胞凝集体における低酸素誘導因子の発現とドキソルビシンに対する抵抗性の検討

  鎌田理代; 野口友里; 江藤彩奈; 宮崎和穂; 山本知佳; 油井聡  日本薬学会年会要旨集(CD-ROM)  139th-  2019
• 好中球プロテアーゼで形成された乳がん細胞凝集体は低酸素状態になる

  鎌田理代; 油井聡  日本薬学会年会要旨集(CD-ROM)  138th-  2018
• 好中球カテプシンGの乳がん細胞MCF-7に対する結合と細胞内取り込み

  佐久間裕; 幕内真央; 鎌田理代; 油井聡  日本薬学会年会要旨集(CD-ROM)  136th-  2016
• カテプシンGにより惹起される乳がん細胞株MCF-7細胞凝集と細胞内型PAF-アセチルヒドロラーゼの発現誘導

  谷川和也; 鎌田理代; 油井聡; 中村康宏; 原田史子; 唐澤健; 井上圭三  脂質生化学研究  56-  2014
• 乳がん細胞凝集を誘導する好中球由来カテプシンGに対する結合分子の同定

  鎌田(森本)理代; 油井聡  日本薬学会年会要旨集(CD-ROM)  133rd-  2013

Research Grants & Projects

• 好中球カテプシンGをターゲットとした新規乳がん悪性化機序の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2023/04 -2026/03 

  Author : 鎌田 理代
• Elusidation of the mechanism of neutrophil cathepsin G induces breast cancer cell aggregation and metastasis

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2015/04 -2018/03 

  Author : Morimoto-Kamata Riyo
• The function of the homeobox gene Hex in chondrogenesis

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2007 -2009 

  Author : MORIMOTO Riyo
• グルタミン酸作動性付与因子・小胞型グルタミン酸輸送体の構造と機能に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2004 -2005 

  Author : 森本 理代

Teaching Experience

Comprehensive pharmacy lectureComprehensive pharmacy lecture Teikyo University

Others

• 2000/05 - Today 薬剤師免許