Uezono Takashi

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Associate Professor
Graduate School of Pharmaceutical Sciences Associate Professor

Degree

• Doctor of Pharmaceutical Sciences（Kyoto University）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901078479101180

J-Global ID

• 200901078479101180

Research Interests

• Neurochemistry   神経化学   

Research Areas

• Life sciences / Pharmacology
• Life sciences / Pharmaceuticals - health and biochemistry

Association Memberships

• 日本薬理学会   日本薬学会   

Research Activity Information

Published Papers

• Role of Prostaglandins in Nitric Oxide-Induced Glial Cell-Mediated Vasodilation in Rat Retina

  Asami Mori; Haruka Seki; Satoru Mizukoshi; Takashi Uezono; Kenji Sakamoto

  Biomolecules MDPI AG 12 (10) 1403 - 1403 2022/10
• Anterograde amnesia by the illicit use of benzodiazepines

  Keiko Shimizu; Osamu Saito; Kento Ogawa; Hajime Mizukami; Takashi Uezono; Hiroshi Shiono; Toshio Awaya; Yasuyuki Fujita; Kazuo Matsubara

  Japanese Journal of Forensic Toxicology 19 (2) 122 - 123 0915-9606 2001
• Stereoselective analyses of selegiline metabolites: possible urinary markers for selegiline therapy

  M Hasegawa; K Matsubara; S Fukushima; C Maseda; T Uezono; K Kimura

  FORENSIC SCIENCE INTERNATIONAL 101 (2) 95 - 106 0379-0738 1999/04 [Refereed]
  
• Reduced dorsal hippocampal glutamate release significantly correlates with the spatial memory deficits produced by benzodiazepines and ethanol

  K Shimizu; K Matsubara; T Uezono; K Kimura; H Shiono

  NEUROSCIENCE 83 (3) 701 - 706 0306-4522 1998/04 [Refereed]
  
• Stability of a metabolizable ester bond in radioimmunoconjugates

  Y Arano; K Wakisaka; T Mukai; T Uezono; H Motonari; H Akizawa; C Kairiyama; Y Ohmomo; C Tanaka; M Ishiyama; H Sakahara; J Konishi; A Yokoyama

  NUCLEAR MEDICINE AND BIOLOGY 23 (2) 129 - 136 0883-2897 1996/02 [Refereed]
  
• Stability of a metabolizable ester bond in radioimmunoconjugates

  Yasushi Arano; Kouji Wakisaka; Takahiro Mukai; Takashi Uezono; Hiroshi Motonari; Hiromichi Akizawa; Claudia Kairiyama; Yoshiro Ohmomo; Chiaki Tanaka; Munetaka Ishiyama; Harumi Sakahara; Junji Konishi; Akira Yokoyama

  Nuclear Medicine and Biology Elsevier Inc. 23 (2) 129 - 136 0969-8051 1996
• RADIOLABELED METABOLITES OF PROTEINS PLAY A CRITICAL ROLE IN RADIOACTIVITY ELIMINATION FROM THE LIVER

  Y ARANO; T MUKAI; H AKIZAWA; T UEZONO; H MOTONARI; K WAKISAKA; C KAIRIYAMA; A YOKOYAMA

  NUCLEAR MEDICINE AND BIOLOGY 22 (5) 555 - 564 0883-2897 1995/07 [Refereed]
  
• Radiolabeled metabolites of proteins play a critical role in radioactivity elimination from the liver

  Yasushi Arano; Takahiro Mukai; Hiromichi Akizawa; Takashi Uezono; Hiroshi Motonari; Kouji Wakisaka; Claudia Kairiyama; Akira Yokoyama

  Nuclear Medicine and Biology 22 (5) 555 - 564 0969-8051 1995/07
• Maleimidoethyl 3-(Tri-n-butylstannyl)hippurate: A Useful Radioiodination Reagent for Protein Radiopharmaceuticals To Enhance Target Selective Radioactivity Localization

  Yasushi Arano; Kouji Wakisaka; Yoshiro Ohmomo; Takashi Uezono; Takahiro Mukai; Hiroshi Motonari; Hiromitsu Shiono; Harumi Sakahara; Junji Konishi; Chiaki Tanaka; Akira Yokoyama

  Journal of Medicinal Chemistry 37 (16) 2609 - 2618 0022-2623 1994/08
• A BIOLOGICAL METHOD TO EVALUATE BIFUNCTIONAL CHELATING-AGENTS TO LABEL ANTIBODIES WITH METALLIC RADIONUCLIDES

  Y ARANO; T MUKAI; T UEZONO; K WAKISAKA; H MOTONARI; H AKIZAWA; Y TAOKA; A YOKOYAMA

  JOURNAL OF NUCLEAR MEDICINE 35 (5) 890 - 898 0161-5505 1994/05

MISC

• Captopril enhances cardiac vagal but not sympathetic neurotransmission in pithed rats

  Y Takata; T Arai; S Suzuki; J Kurihara; T Uezono; Y Okubo; H Kato  JOURNAL OF PHARMACOLOGICAL SCIENCES  95-  (3)  390  -393  2004/07
• Simple method of methylation for gas chromatographic analysis of S-benzyl-N-acetylcysteine, a metabolite of toluene, in human urine

  S Takahashi; T Uezono; A Akane; S Takahashi'  JOURNAL OF ANALYTICAL TOXICOLOGY  26-  (4)  189  -192  2002/05
• Simultaneous analyses of hypoglycemic agents and C-peptide are essential in a homicide case with the combined dosing insulin and insulin-releasing drug

  Takashi Uezono; Hiroshi Shiono; Keiko Shimizu; Kento Ogawa; Osamu Saito; Masatsugu Yoshida; Hajime Mizukami; Kazuo Matsubara  Legal Medicine  4-  (1)  34  -36  2002
• Carrier-mediated processes in blood-brain barrier penetration and neural uptake of paraquat

  K Shimizu; K Ohtaki; K Matsubara; K Aoyama; T Uezono; O Saito; M Suno; K Ogawa; N Hayase; K Kimura; H Shiono  BRAIN RESEARCH  906-  (1-2)  135  -142  2001/07
• L-deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP+ and beta-carbolinium: a microdialysis study in rats

  K Matsubara; T Senda; T Uezono; T Awaya; S Ogawa; K Chiba; K Shimizu; N Hayase; K Kimura  NEUROSCIENCE LETTERS  302-  (2-3)  65  -68  2001/04
• Glutamate is not involved in the MPP+-induced dopamine overflow in the striatum of freely moving C57BL/6 mice

  T Uezono; K Matsubara; K Shimizu; H Mizukami; K Ogawa; O Saito; N Hayase; H Eto; K Kimura; H Shiono  JOURNAL OF NEURAL TRANSMISSION  108-  (8-9)  899  -908  2001
• Norharman, an indoleamine-derived beta-carboline, but not Trp-P-2, a gamma-carboline, induces apoptotic cell death in human neuroblastoma SH-SY5Y cells

  T Uezono; W Maruyama; K Matsubara; M Naoi; K Shimizu; O Saito; K Ogawa; H Mizukami; N Hayase; H Shiono  JOURNAL OF NEURAL TRANSMISSION  108-  (8-9)  943  -953  2001
• The tissue distribution of lidocaine in acute death due to overdosing

  Keiko Shimizu; Hiroshi Shiono; Kazuo Matsubara; Toshio Awaya; Tomoyuki Takahashi; Osamu Saito; Kento Ogawa; Hajime Mizukami; Takashi Uezono; Hiroaki Akutsu  Legal Medicine  2-  (2)  101  -105  2000
• N-methylation ability for azaheterocyclic amines is higher in Parkinson's disease: nicotinamide loading test

  K Aoyama; K Matsubara; K Okada; S Fukushima; K Shimizu; S Yamaguchi; T Uezono; M Satomi; N Hayase; S Ohta; H Shiono; S Kobayashi  JOURNAL OF NEURAL TRANSMISSION  107-  (8-9)  985  -995  2000
• Forensic diagnosis of death from cold

  Hajime Mizukami; Keiko Shimizu; Hiroshi Shiono; Takashi Uezono; Masahiro Sasaki  Legal Medicine  1-  (4)  204  -209  1999
• Renal metabolism of In-111-DTPA-D-Phe(1)-octreotide in vivo

  H Akizawa; Y Arano; T Uezono; M Ono; Y Fujioka; T Uehara; A Yokoyama; K Akaji; Y Kiso; M Koizumi; H Saji  BIOCONJUGATE CHEMISTRY  9-  (6)  662  -670  1998/11
• Structural significance of azaheterocyclic amines related to Parkinson's disease for dopamine transporter

  K Matsubara; T Senda; T Uezono; S Fukushima; S Ohta; K Igarashi; M Naoi; Y Yamashita; K Ohtaki; N Hayase; S Akutsu; K Kimura  EUROPEAN JOURNAL OF PHARMACOLOGY  348-  (1)  77  -84  1998/05
• Endogenously occurring beta-carboline induces parkinsonism in nonprimate animals: A possible causative protoxin in idiopathic Parkinson's disease

  K Matsubara; T Gonda; H Sawada; T Uezono; Y Kobayashi; T Kawamura; K Ohtaki; K Kimura; A Akaike  JOURNAL OF NEUROCHEMISTRY  70-  (2)  727  -735  1998/02
• A novel chemical strategy to reduce renal radioactivity levels of antibody fragments.

  Y Arano; K Wakisaka; H Akizawa; T Uezono; M Ono; H Saji; T Saga; H Sakahara; J Konishi  JOURNAL OF NUCLEAR MEDICINE  38-  (5)  103  -103  1997/05
• Conventional and high-yield synthesis of DTPA-conjugated peptides: Application of a monoreactive DTPA to DTPA-D-Phe(1)-octreotide synthesis

  Y Arano; H Akizawa; T Uezono; K Akaji; M Ono; S Funakoshi; M Koizumi; A Yokoyama; Y Kiso; H Saji  BIOCONJUGATE CHEMISTRY  8-  (3)  442  -446  1997/05
• A Novel Radioiodination Reagent for Protein Radiopharmaceuticals with L-Lysine as a Plasma-Stable Metabolizable Linkage to Liberate meta-Iodohippuric Acid after Lysosomal Proteolysis.

  WAKISAKA K; ARANO Y; UEZONO T; AKIZAWA H; ONO M; KAWAI K; OHOMOMO Y; NAKAYAMA M; SAJI H  J. Med. Chem.  40-  (16)  2643  -2652  1997
• Reassessment of diethylenetriaminepentaacetic acid (DTPA) as a chelating agent for indium-111 labeling of polypeptides using a newly synthesized monoreactive DTPA derivative

  Y Arano; T Uezono; H Akizawa; M Ono; K Wakisaka; M Nakayama; H Sakahara; J Konishi; A Yokoyama  JOURNAL OF MEDICINAL CHEMISTRY  39-  (18)  3451  -3460  1996/08
• Selective release of iodohippuric acid from a covalently conjugated protein in lysosomes by a plasma-stable metabolizable amide linkage.

  Y Arano; K Wakisaka; T Uezono; H Akizawa; M Ono; Y Iida; A Yokoyama  JOURNAL OF NUCLEAR MEDICINE  37-  (5)  17  -17  1996/05
• Assessment of radiochemical design of antibodies using an ester bond as the metabolizable linkage: Evaluation of maleimidoethyl 3-(tri-n-butylstannyl)hippurate as a radioiodination reagent of antibodies for diagnostic and therapeutic applications

  Yasushi Arano; Kouji Wakisaka; Yoshiro Ohmono; Takashi Uezono; Hiromichi Akizawa; Morio Nakayama; Harumi Sakahara; Chiaki Tanaka; Junji Konishi; Akira Yokoyama  Bioconjugate Chemistry  7-  (6)  628  -637  1996
• BIOLOGICAL COMPARISON OF BENZYL-EDTA DERIVATIVES FOR IN-111 LABELING OF MABS AND PEPTIDES

  Y ARANO; T MUKAI; H MOTONARI; H AKIZAWA; T UEZONO; A YOKOYAMA  JOURNAL OF NUCLEAR MEDICINE  35-  (5)  P259  -P259  1994/05
• A novel radioiodination reagent for antibodies with an ester bond to release an iodohippuric acid

  Y. Arano; K. Wakisaka; Y. Ohmomo; T. Mukai; T. Uezono; H. Motonari; H. Sakahara; J. Konishi; C. Tanaka; A. Yokoyama  Journal of Labelled Compounds and Radiopharmaceuticals  35-  368  -370  1994/01
• Biological comparison of DTPA and SCN-benzyl-EDTA as chelating agents for indium-labeling of antibodies

  Y. Arano; T. Mukai; T. Uezono; H. Motonari; K. Wakisaka; A. Yokoyama  Journal of Labelled Compounds and Radiopharmaceuticals  35-  381  -383  1994
• A NOVEL BIOLOGICAL METHOD TO EVALUATE CHELATING-AGENTS FOR LABELING ANTIBODIES WITH METALLIC RADIONUCLIDES

  Y ARANO; T MUKAI; T UEZONO; Y TAOKA; A YOKOYAMA  JOURNAL OF NUCLEAR MEDICINE  34-  (5)  P59  -P59  1993/05

Research Grants & Projects

• The Establishment of diagnosis and the forensic pathological study on death in the cold.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2001 -2003 

  Author : SHIONO Hiroshi; SHIMIZU Keiko
• Initiating and preventing factors in neurodegeneration underlying Parkinson's disease

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2000 -2002 

  Author : MATSUBARA Kazuo; SHIMIZU Keiko
• 一酸化炭素(CO)曝露による神経細胞死の新機構の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2000 -2001 

  Author : 上園 崇
• Polymorphism of Microsatellite Markers on Human Sex Chromosomes and analysis of mutation rate in the same individual.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1999 -2000 

  Author : SHIONO Hiroshi; UEZONO Takashi; SHIMIZU Keiko
• Age-Related Change in Blood-Brain Barrier Penetration of Drugs

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1998 -1999 

  Author : MATSUBARA Kazuo; UEZONO Takashi; SHIMIZU Keiko
• ANALYSIS OF β-PHENYLETHYLAMINE AND CHANGES OF ITS LEVEL IN THE BRAIN AFTER ADMINISTRATION OF METHAMPHETAMINE

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1998 -1999 

  Author : KIMURA Kojiro; YAKABE Tomohiro; ETO Hideaki; TAKAHASHI Setsunori
• The underlying mechanism of delayed degenerative alteration in the basal ganglia after carbon monoxide poisoning

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1997 -1998 

  Author : UEZONO Takashi; MATSUBARA Kazuo; KIMURA Kojiro
• POSTMORTEM CHANGES OF VOLATILE COMPOUNDS DETECTED IN DECOMPOSED TISSUES

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1996 -1997 

  Author : KIMURA Kojiro; UEZONO Takashi; TAKAHASHI Setsunori; MATSUBARA Kazuo
• 神経細胞死に関する研究

  その他の研究制度
• Study on neuronal cell death

  The Other Research Programs