Sekimizu Kazuhisa

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Specially Appointed Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202301016710211380

Research funding number

• 90126095

J-Global ID

• 202301016710211380

Research Interests

• Drug discoveries with silkworms   

Research Activity Information

Published Papers

• Human gut associated Bacteroides and Akkermansia bacteria exhibit immunostimulatory activity in the silkworm muscle contraction assay.

  Fumiaki Tabuchi; Chie Kano; Tatsuhiko Hirota; Tomomasa Kanda; Kazuhisa Sekimizu; Atsushi Miyashita

  Drug discoveries & therapeutics 2025/02
• Discovery of new AMR drugs targeting modulators of antimicrobial activity using in vivo silkworm screening systems

  Fumiaki Tabuchi; Kazuhiro Mikami; Masanobu Miyauchi; Kazuhisa Sekimizu; Atsushi Miyashita

  The Journal of Antibiotics Springer Science and Business Media LLC 0021-8820 2024/11
• Molecular Editing Enhances Oxidation Resistance of Mena‐quinone‐Targeting Antibiotics Lysocin E and WAP‐8294A2

  Junhao Fu; Yosuke Nakata; Hiroaki Itoh; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue

  Chemistry – A European Journal Wiley 0947-6539 2023/06
• Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives.

  Yosuke Nakata; Junhao Fu; Hiroaki Itoh; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue

  Chemistry (Weinheim an der Bergstrasse, Germany) e202301225  2023/05
• High molecular weight glucose homopolymer of broccoli (Brassica oleracea var. italica) stimulates both invertebrate and mammalian immune systems

  Atsushi Miyashita; Keiko Kataoka; Toshio Tsuchida; Akihiko Ano Ogasawara; Hiroto Nakajima; Megumu Takahashi; Kazuhisa Sekimizu

  Frontiers in Food Science and Technology Frontiers Media SA 3 2023/02
• 選抜ワークショップ5:抗菌性物質、薬剤耐性 新規抗生物質ライソシンEは宿主と微生物の相互作用を利用して高い治療効果を発揮する

  浜本 洋; Panthee Suresh; Paudel Atmika; 宮下 惇嗣; 関水 和久

  日本細菌学雑誌 日本細菌学会 77 (1) 57 - 57 0021-4930 2022/02
• Repurposing the PDMA-approved drugs in Japan using an insect model of staphylococcal infection.

  Atsushi Miyashita; Shuhei Mitsutomi; Tohru Mizushima; Kazuhisa Sekimizu

  FEMS microbes 3 xtac014  2022
• Contribution of rsaC, a small non-coding RNA, towards the pathogenicity of Staphylococcus aureus in a mouse systemic infection model

  Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Suguru Ohgi; Kazuhisa Sekimizu

  bioRxiv Cold Spring Harbor Laboratory 2021/10
• in vivo RNA-Seq解析に基づくCryptococcus neoformansの病原性因子の網羅的探索

  浜本 洋; 石島 早苗; スレス・パンシー; アトミカ・パウデル; 関水 和久

  日本医真菌学会雑誌 (一社)日本医真菌学会 62 (Suppl.1) 100 - 100 2434-5229 2021/10
• Transcriptome change in Staphylococcus aureus in infecting mice

  Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Ohgi Suguru; Yutaka Suzuki; Kazuhisa Sekimizu

  preprint on ResearchSquare Research Square Platform LLC 2021/07
• Purification of immunostimulatory glucose homopolymer from broccoli (Brassica oleracea var. italica)

  Atsushi Miyashita; Keiko Kataoka; Toshio Tsuchida; Akihiko Ano Ogasawara; Hiroshi Hamamoto; Megumu Takahashi; Kazuhisa Sekimizu

  bioRxiv Cold Spring Harbor Laboratory 2021/05
• Activation of innate immunity by neutral polysaccharides from broccoli buds

  Atsushi Miyashita; Keiko Kataoka; Kazuhisa Sekimizu

  bioRxiv Cold Spring Harbor Laboratory 2021/03
• Serum proteins potentiate therapeutic efficacy of lysocin E against S. aureus

  Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Kenichi Ishii; Jyunichiro Yasukawa; Su Jie; Hiroaki Itoh; Kotaro Tokumoto; Masayuki Inoue; Kazuhisa Sekimizu

  preprint at researchsquare Research Square 2020/11
• 白癬菌汚染した靴を揮発性の抗菌アロマ成分を用いて除菌する実用法の開発 インソール;靴中敷

  石島 早苗; 比留間 政太郎; 大島 浩智; 鈴木 修; 村井 隆; 笠井 庄治; 江澤 邦夫; 関水 和久; 安部 茂

  日本医真菌学会雑誌 (一社)日本医真菌学会 61 (Suppl.) 89 - 89 2434-5229 2020/09
• Cryptococcus neoformansの病原性因子の網羅的探索

  浜本 洋; 石島 早苗; スレス・パンシー; アトミカ・パウデル; 関水 和久

  日本医真菌学会雑誌 (一社)日本医真菌学会 61 (Suppl.) 82 - 82 2434-5229 2020/09
• 酵母加熱死菌によるカイコの自然免疫の過度な活性化と殺傷

  石島 早苗; 宮下 惇嗣; 浜本 洋; 関水 和久

  日本医真菌学会雑誌 (一社)日本医真菌学会 61 (Suppl.) 86 - 86 2434-5229 2020/09
• Candida albicans TIMM1768株の全ゲノム配列の解析

  浜本 洋; Panthee Suresh; Paudel Atmika; 石島 早苗; 関水 和久

  Medical Mycology Research 帝京大学医真菌研究センター 9 (1) 37 - 40 1883-3195 2018/12
• 山椒Zanthoxylum piperitumのCandida albicans菌糸形発育抑制効果

  羽山 和美; 田口 裕基; 関水 和久; 安部 茂

  Medical Mycology Journal (一社)日本医真菌学会 59 (Suppl.1) 91 - 91 2185-6486 2018/08
• リゾチーム-キトサン複合体、LYZOX(リゾックス)及びデカン酸との組み合わせの抗真菌素材としての可能性

  影島 宏紀; 関水 和久; 安部 茂; 山田 剛; 羽山 和美; 高橋 美貴; 村上 洋一; 齊藤 章; 平野 翔一郎

  Medical Mycology Journal (一社)日本医真菌学会 59 (Suppl.1) 94 - 94 2185-6486 2018/08
• ナノポアシークエンサーを用いたCandida albicans TIMM1768株の全ゲノム解析

  浜本 洋; スレス・パンシー; 石島 早苗; 関水 和久

  Medical Mycology Journal (一社)日本医真菌学会 59 (Suppl.1) 87 - 87 2185-6486 2018/08
• Candida albicans TIMM1768株の酵母形、菌糸形での発現遺伝子解析

  石島 早苗; 浜本 洋; 山田 剛; 安部 茂; 関水 和久

  Medical Mycology Journal (一社)日本医真菌学会 59 (Suppl.1) 87 - 87 2185-6486 2018/08
• ショ糖の摂食による血糖値の上昇を抑制する物質の探索のためのカイコの応用

  松本 靖彦; 石井 雅樹; 関水 和久

  Medical Mycology Research 帝京大学医真菌研究センター 8 (1) 33 - 38 1883-3195 2017/12 [Refereed]
  
• Silkworm infection models of filamentous fungi for developing antifungal agents

  石井 雅樹; 松本 靖彦; 山田 剛; 安部 茂; 関水 和久

  Medical mycology research 帝京大学医真菌研究センター 8 (1) 39 - 43 1883-3195 2017 [Refereed]
  
• 病原性真菌Cryptococcus neoformansの感染機構の解明のためカイコの利用

  松本 靖彦; 石井 雅樹; 関水 和久

  Medical Mycology Research 帝京大学医真菌研究センター 7 (1) 21 - 25 1883-3195 2016/12 [Refereed]
  
• 新規抗生物質カイコシンEの治療効果の基礎となる分子メカニズム

  安川 淳一朗; 浜本 洋; ジー・スー; パウデル・アトミカ; 浦井 誠; 西田 智; 関水 和久

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 87回 [4T13a - 09] 2014/10 [Refereed]
  
• Impact of psm-mec in the mobile genetic element on the clinical characteristics and outcome of SCCmec-II methicillin-resistant Staphylococcus aureus bacteraemia in Japan

  Aoyagi T; Kaito C; Sekimizu K; Omae Y; Saito Y; Mao H; Inomata S; Hatta M; Endo S; Kanamori H; Gu Y; Tokuda K; Yano H; Kitagawa M; Kaku M

  Clin Microbiol Infect. WILEY-BLACKWELL 20 (9) 912 - 919 1198-743X 2014/09 [Refereed]
  
• Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents (vol 66, pg 663, 2013)

  Atmika Paudel; Keiichi Kaneko; Ayako Watanabe; Shigeki Matsunaga; Motomu Kanai; Hiroshi Hamamoto; Kazuhisa Sekimizu

  JOURNAL OF ANTIBIOTICS JAPAN ANTIBIOTICS RESEARCH ASSOC 67 (2) 203 - 203 0021-8820 2014/02 [Refereed]
  
• Physiological comparison between mulberry (Morus alba L.) Leaves diet and artificial diet on growth development as well as antibiotic therapeutic response of silkworms

  Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi

  Australian Journal of Crop Science 7 (13) 2029 - 2035 1835-2693 2013
• Evaluation of Innate Immune Stimulating Activity of Polysaccharides Using a Silkworm (Bombyx Mori) Muscle Contraction Assay

  Tomoko Fujiyuki; Tadahiro Takeda; Hiroshi Hamamoto; Kenichi Ishii; Makoto Urai; Keiko Kataoka; Shoji Shibata; Kazuhisa Sekimizu

  drug discoveries & therapeutics 2 6 (2) 88 - 93 1881-784x 2013 [Refereed]
  
• Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay.

  Saphala Dhital; Hiroshi Hamamoto; Makoto Urai; Kenichi Ishii; Kazuhisa Sekimizu

  Drug Discoveries & Therapeutics 1 5 (1) 18 - 25 1881-7831 2011/02 [Refereed]
  
• Isolation of mammalian pathogenic bacteria using silkworms

  Kaito C; Usui K; Kyuma T; Sekimizu K

  Drug Discoveries and Therapeutics 5 (2) 66 - 70 2011 [Refereed]
  
• Hemocytes and humoral factors in silkworm blood are cooperatively involved in sheep erythrocyte aggregation

  Katsutoshi Imamura; Kenichi Ishii; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Drug Discoveries & Therapeutics 3 5 (3) 125 - 129 1881-784X 2011 [Refereed]
  
• Evaluation of therapeutic effects and pharmacokinetics of antibacterial chromogenic agents in a silkworm model of Staphylococcus aureus infection.

  Fujiyuki T; Imamura K; Hamamoto H; Sekimizu K

  Drug Discoveries & Therapeutics 5 4 (5) 349 - 354 1881-7831 2010/10 [Refereed]
  
• 薬剤耐性菌アップデイト 宿主免疫回避におけるサルモネラ薬剤排出ポンプの生理的役割

  西野 邦彦; 坂田 博樹; 二階堂 英司; 城阪 郁江; 西野 美都子; 松本 佳巳; 松本 靖彦; 垣内 力; 関水 和久; 山口 明人; 上田 珠美; 田中 真奈美; 中濃 知志

  日本細菌学雑誌 日本細菌学会 64 (1) 91 - 91 0021-4930 2009/02 [Refereed]
  
• Pharmacologic action of oseltamivir on the nervous system.

  Kenichi Ishii; Hiroshi Hamamoto; Takuya Sasaki; Yuji Ikegaya; Kenzo Yamatsugu; Motomu Kanai; Masakatsu Shibasaki; Kazuhisa Sekimizu

  Drug Discoveries & Therapeutics 1 2 (1) 24 - 34 1881-7831 2008/02 [Refereed]
  
• A novel method to suppress the dispersal of Japanese cedar pollen by inducing morphologic changes with weak alkaline solutions.

  Kenichi Ishii; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Drug Discoveries & Therapeutics 2 1 (2) 124 - 129 1881-7831 2007/10 [Refereed]
  
• Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain

  H Takeuchi; E Kage; M Sawata; A Kamikouchi; K Ohashi; M Ohara; T Fujiyuki; T Kunieda; K Sekimizu; S Natori; T Kubo

  INSECT MOLECULAR BIOLOGY BLACKWELL SCIENCE LTD 10 (5) 487 - 494 0962-1075 2001/10 [Refereed]
  

Conference Activities & Talks

• Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret.

  Hiroshi Hamamoto; Atsushi Miyashita; Koushirou Kamura; Ryo Horie; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2022/12
• Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus).

  Atsushi Miyashita; Kazuhisa Sekimizu; Chikara Kaito

  Drug discoveries & therapeutics  2022/11
• Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220.

  Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Chikara Kaito; Yutaka Suzuki; Kazuhisa Sekimizu

  Heliyon  2022/11
• Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.

  Geberemichal Geberetsadik; Akane Inaizumi; Akihito Nishiyama; Takehiro Yamaguchi; Hiroshi Hamamoto; Suresh Panthee; Aki Tamaru; Manabu Hayatsu; Yusuke Mizutani; Shaban Amina Kaboso; Mariko Hakamata; Aleksandr Ilinov; Yuriko Ozeki; Yoshitaka Tateishi; Kazuhisa Sekimizu; Sohkichi Matsumoto

  Antimicrobial agents and chemotherapy  2022/09
• Transcriptome change of Staphylococcus aureus in infected mouse liver.

  Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Suguru Ohgi; Yutaka Suzuki; Koichi Makimura; Kazuhisa Sekimizu

  Communications biology  2022/07
• Peanut triacylglycerols activate innate immunity both in insects and mammals.

  Wenyuan Li; Atsushi Miyashita; Kazuhisa Sekimizu

  Scientific reports  2022/05
• Establishment of a polymerase chain reaction-based method for strain-level management of Enterococcus faecalis EF-2001 using species-specific sequences identified by whole genome sequences.

  Hiroshi Hamamoto; Akihiko Ano Ogasawara; Masahiro Iwasa; Kazuhisa Sekimizu

  Frontiers in microbiology  2022
• An efficient method to screen for the soil bacteria producing therapeutically effective antibiotics.

  Hiroshi Hamamoto; Suresh Panthee; Kana Hashimoto; Toshio Tsuchida; Kazuhisa Sekimizu

  The Journal of antibiotics  2021/12
• YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus.

  Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Tom Grunert; Kazuhisa Sekimizu

  Virulence  2021/12
• Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model.

  Suresh Panthee; Hiroshi Hamamoto; Yayoi Nishiyama; Atmika Paudel; Kazuhisa Sekimizu

  Journal of fungi (Basel, Switzerland)  2021/11
• Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus.

  Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Kenichi Ishii; Jyunichiro Yasukawa; Jie Su; Atsushi Miyashita; Hiroaki Itoh; Kotaro Tokumoto; Masayuki Inoue; Kazuhisa Sekimizu

  Nature communications  2021/11
• A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies.

  Hiroto Nakajima; Atsushi Miyashita; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Scientific reports  2021/05
• Evaluation of pathogenicity and therapeutic effectiveness of antibiotics using silkworm Nocardia infection model.

  Kazuhiro Mikami; Kazunari Sonobe; Keiko Ishino; Takumi Noda; Mami Kato; Mami Hanao; Hiroshi Hamamoto; Kazuhisa Sekimizu; Mitsuhiro Okazaki

  Drug discoveries & therapeutics  2021/05
• Using silkworms to search for lactic acid bacteria that contribute to infection prevention and improvement of hyperglycemia.

  Atsushi Miyashita; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2021/05
• Complete genome sequence and comparative genomic analysis of Enterococcus faecalis EF-2001, a probiotic bacterium.

  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Akihiko Ano Ogasawara; Toshihiro Iwasa; Jochen Blom; Kazuhisa Sekimizu

  Genomics  2021/05
• A digital scheme of human trials for the evaluation of functional foods.

  Atsushi Miyashita; Kazuyuki Shimomura; Hiroto Nakajima; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2021/03
• Applying the silkworm model for the search of immunosuppressants.

  Atsushi Miyashita; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2021
• Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library.

  Yuri Takada; Hiroaki Itoh; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue

  Nature communications  2020/10
• A simple artificial diet available for research of silkworm disease models.

  Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2020/09
• Large-Scale Screening and Identification of Novel Pathogenic Staphylococcus aureus Genes Using a Silkworm Infection Model.

  Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  The Journal of infectious diseases  2020/05
• Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter.

  Chikara Kaito; Hirono Yoshikai; Ai Wakamatsu; Atsushi Miyashita; Yasuhiko Matsumoto; Tomoko Fujiyuki; Masaru Kato; Yoshitoshi Ogura; Tetsuya Hayashi; Takao Isogai; Kazuhisa Sekimizu

  PLoS pathogens  2020/04
• The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus.

  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Anne-Catrin Uhlemann; Kazuhisa Sekimizu

  Frontiers in microbiology  2020
• Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells.

  Yasuhiko Matsumoto; Miki Takahashi; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2020
• GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus.

  Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu

  RSC advances  2019/11
• Suppressive effects of whey protein hydrolysate on sucrose-induced hyperglycemia in silkworms.

  Yasuhiko Matsumoto; Miki Takahashi; Masahiro Umehara; Masato Asano; Hiroko Maruki-Uchida; Minoru Morita; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2019/11
• Identification of 2H phosphoesterase superfamily proteins with 2'-CPDase activity.

  Shuhei Mitsutomi; Nobuyoshi Akimitsu; Kazuhisa Sekimizu; Chikara Kaito

  Biochimie  2019/10
• Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment.

  Daniel Don Nwibo; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2019/07
• Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E.

  Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue

  Nature communications  2019/07
• Pharmacokinetics of anti-infectious reagents in silkworms.

  Hiroshi Hamamoto; Ryo Horie; Kazuhisa Sekimizu

  Scientific reports  2019/07
• Silkworm as an experimental animal for research on fungal infections.

  Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Microbiology and immunology  2019/02
• Detection of Trichophyton spp. from footwear of patients with tinea pedis.

  Sanae A Ishijima; Masataro Hiruma; Kazuhisa Sekimizu; Shigeru Abe

  Drug discoveries & therapeutics  2019
• Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis.

  Suresh Panthee; Atmika Paudel; Jochen Blom; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Frontiers in microbiology  2019
• Additive effects of Kothala himbutu (Salacia reticulata) extract and a lactic acid bacterium (Enterococcus faecalis YM0831) for suppression of sucrose-induced hyperglycemia in an in vivo silkworm evaluation system.

  Masaki Ishii; Yasuhiko Matsumoto; Toshiaki Katada; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2019
• Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph.

  Hiroki Ryuno; Fuki Nigo; Isao Naguro; Kazuhisa Sekimizu; Chikara Kaito

  PloS one  2019
• Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans.

  Yasuhiko Matsumoto; Masaki Ishii; Setsuo Hasegawa; Kazuhisa Sekimizu

  Communications biology  2019
• Bacterial polysaccharides inhibit sucrose-induced hyperglycemia in silkworms.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2018/09
• Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 1768.

  Suresh Panthee; Hiroshi Hamamoto; Sanae A Ishijima; Atmika Paudel; Kazuhisa Sekimizu

  Genome biology and evolution  2018/08
• Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.

  Tomohiro Maruyama; Takashi Baba; Yuki Maemoto; Chikako Hara-Miyauchi; Minami Hasegawa-Ogawa; Hirotaka James Okano; Yuki Enda; Kei Matsumoto; Nagisa Arimitsu; Kazuki Nakao; Hiroshi Hamamoto; Kazuhisa Sekimizu; Takayo Ohto-Nakanishi; Hiroki Nakanishi; Takeshi Tokuyama; Shigeru Yanagi; Mitsuo Tagaya; Katsuko Tani

  Cell death & disease  2018/07
• Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic.

  Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue

  The Journal of organic chemistry  2018/07
• Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model.

  Atmika Paudel; Suresh Panthee; Makoto Urai; Hiroshi Hamamoto; Tomohiko Ohwada; Kazuhisa Sekimizu

  Scientific reports  2018/01
• Establishment of a gnotobiotic silkworm model.

  Hiroto Nakajima; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2018
• Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation system.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2018
• [Development of Antibiotics Using Silkworm Bacteria and Fungi Infection Model].

  Hiroshi Hamamoto; Kazuhisa Sekimizu

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  2018
• [Platform Development for Drug Discovery Utilizing Silkworm towards "Novel Industrial Revolution"].

  Kazuhisa Sekimizu; Kohji Itoh

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  2018
• Estimation of lactic acid bacterial cell number by DNA quantification.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2018
• In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms.

  Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi

  Pharmaceutical biology  2017/12
• Evaluation of the innate immune-stimulating activity of amazake using a silkworm muscle contraction assay.

  Hiroko Maruki-Uchida; Masahiko Sai; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2017/11
• Isolation of antibiotic-producing Pseudomonas species with low-temperature cultivation of temperate soil.

  Shuhei Mitsutomi; Kazuhisa Sekimizu; Chikara Kaito

  Drug discoveries & therapeutics  2017/11
• Two-spotted cricket as an animal infection model of human pathogenic fungi.

  Yuto Kochi; Yasuhiko Matsumoto; Kazuhisa Sekimizu; Chikara Kaito

  Drug discoveries & therapeutics  2017/11
• Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from Rhizobium sp. strain M2 screened using a silkworm muscle contraction assay.

  Makoto Urai; Tomoko Aizawa; Katsutoshi Imamura; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2017/11
• Structural analysis of an innate immunostimulant from broccoli, Brassica oleracea var. italica.

  Makoto Urai; Keiko Kataoka; Satoshi Nishida; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2017/11
• An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis.

  Masaki Ishii; Yasuhiko Matsumoto; Tsuyoshi Yamada; Shigeru Abe; Kazuhisa Sekimizu

  Scientific reports  2017/09
• Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions.

  Haruka Fujino; Masanori Nagatomo; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue

  Angewandte Chemie (International ed. in English)  2017/09
• D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus.

  Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu

  The Journal of antibiotics  2017/07
• Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b.

  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Genome announcements  2017/06
• Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus.

  Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu

  The Journal of antibiotics  2017/06
• Genomic analysis of vancomycin-resistant Staphylococcus aureus VRS3b and its comparison with other VRSA isolates.

  Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2017/05
• Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract.

  Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi

  Drug discoveries & therapeutics  2017/05
• Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori).

  Kantaporn Kheawfu; Surachai Pikulkaew; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi

  Drug discoveries & therapeutics  2017/05
• Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis.

  Akiho Yagi; Ryuji Uchida; Hiroshi Hamamoto; Kazuhisa Sekimizu; Ken-Ichi Kimura; Hiroshi Tomoda

  The Journal of antibiotics  2017/05
• Silkworm fungal infection model for identification of virulence genes in pathogenic fungus and screening of novel antifungal drugs.

  Masaki Ishii; Yasuhiko Matsumoto; Ikuko Nakamura; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2017/03
• Decreased sugar concentration in vegetable and fruit juices by growth of functional lactic acid bacteria.

  Masaki Ishii; Yasuhiko Matsumoto; Satoshi Nishida; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2017/03
• Lactic acid bacteria of the Leuconostoc genus with high innate immunity-stimulating activity.

  Masaki Ishii; Satoshi Nishida; Keiko Kataoka; Yayoi Nishiyama; Shigeru Abe; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2017/03
• In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-5.

  Suresh Panthee; Hiroshi Hamamoto; Yutaka Suzuki; Kazuhisa Sekimizu

  The Journal of antibiotics  2017/02
• [A Silkworm Infection Model to Evaluate Antifungal Drugs for Cryptococcosis].

  Yasuhiko Matsumoto; Masaki Ishii; Kiminori Shimizu; Susumu Kawamoto; Kazuhisa Sekimizu

  Medical mycology journal  2017
• A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus.

  Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Keiichi Kaneko; Shigeki Matsunaga; Motomu Kanai; Yutaka Suzuki; Kazuhisa Sekimizu

  Frontiers in microbiology  2017
• [The Usefulness of Silkworms as a Model Animal for Evaluating the Effectiveness of Medicine and Food].

  Kazuhisa Sekimizu

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  2017
• [Development of Novel Antibiotic Lysocin E Identified by Silkworm Infection Model].

  Hiroshi Hamamoto; Kazuhisa Sekimizu

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  2017
• Lactobacillus paraplantarum 11-1 Isolated from Rice Bran Pickles Activated Innate Immunity and Improved Survival in a Silkworm Bacterial Infection Model.

  Satoshi Nishida; Masaki Ishii; Yayoi Nishiyama; Shigeru Abe; Yasuo Ono; Kazuhisa Sekimizu

  Frontiers in microbiology  2017
• Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents.

  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Frontiers in microbiology  2017
• Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection.

  Ikuko Nakamura; Ryuichi Kanasaki; Koji Yoshikawa; Shigetada Furukawa; Akihiko Fujie; Hiroshi Hamamoto; Kazuhisa Sekimizu

  The Journal of antibiotics  2017/01
• Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity.

  Takuya Kaji; Motoki Murai; Hiroaki Itoh; Jyunichiro Yasukawa; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue

  Chemistry (Weinheim an der Bergstrasse, Germany)  2016/11
• A silkworm infection model to investigate Vibrio vulnificus virulence genes.

  Mai Yamamoto; Takashige Kashimoto; Yukihiro Yoshimura; Nao Tachibana; Shiho Kuroda; Yoshiko Miki; Sou Kitabayashi; Ping Tong; Jianbo Xiao; Koichi Tanaka; Hiroshi Hamamoto; Kazuhisa Sekimizu; Koichiro Yamamoto

  Molecular medicine reports  2016/11
• Lysobacter species: a potential source of novel antibiotics.

  Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Kazuhisa Sekimizu

  Archives of microbiology  2016/11
• Novel Nucleoside Diphosphatase Contributes to Staphylococcus aureus Virulence.

  Kenta Imae; Yuki Saito; Hayato Kizaki; Hiroki Ryuno; Han Mao; Atsushi Miyashita; Yutaka Suzuki; Kazuhisa Sekimizu; Chikara Kaito

  The Journal of biological chemistry  2016/09
• A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus.

  Yuto Kochi; Atsushi Miyashita; Kohsuke Tsuchiya; Masao Mitsuyama; Kazuhisa Sekimizu; Chikara Kaito

  FEMS microbiology letters  2016/08
• Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus.

  Atsushi Miyashita; Hayato Kizaki; Kazuhisa Sekimizu; Chikara Kaito

  Biology open  2016/06
• An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia.

  Yasuhiko Matsumoto; Masaki Ishii; Kazuhisa Sekimizu

  Scientific reports  2016/05
• A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus.

  Yasuhiko Matsumoto; Jyunichiro Yasukawa; Masaki Ishii; Yohei Hayashi; Shinya Miyazaki; Kazuhisa Sekimizu

  Scientific reports  2016/03
• Acute oral toxicity test of chemical compounds in silkworms.

  Kimihito Usui; Satoshi Nishida; Takuya Sugita; Takuro Ueki; Yasuhiko Matsumoto; Hidenobu Okumura; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016/02
• Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm.

  Satoshi Nishida; Yasuo Ono; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016/02
• Using silkworms to establish alternative animal models for evaluation of drug-induced tissue injury.

  Yoshinori Inagaki; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016/02
• Using silkworms as a laboratory animal to evaluate medicines and foods.

  Kazuhisa Sekimizu; Hiroshi Hamamoto

  Drug discoveries & therapeutics  2016/02
• Evaluation of anti-diabetic drugs by using silkworm, Bombyx mori.

  Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016/02
• Identification of lysocin E using a silkworm model of bacterial infection.

  Hiroshi Hamamoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016/02
• A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine.

  Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016/02
• Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016/02
• Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins.

  Hirono Yoshikai; Hayato Kizaki; Yuki Saito; Yosuke Omae; Kazuhisa Sekimizu; Chikara Kaito

  The Journal of infectious diseases  2016/01
• An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces.

  Masakazu Nakadai; Shuta Tomida; Kazuhisa Sekimizu

  Scientific reports  2016/01
• Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading.

  Hayato Kizaki; Yosuke Omae; Fumiaki Tabuchi; Yuki Saito; Kazuhisa Sekimizu; Chikara Kaito

  PloS one  2016
• Dividing phase-dependent cytotoxicity profiling of human embryonic lung fibroblast identifies candidate anticancer reagents.

  Yoshinori Inagaki; Yasuhiko Matsumoto; Wei Tang; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016
• Menaquinone as a potential target of antibacterial agents.

  Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2016
• No Effect of Body Size on the Frequency of Calling and Courtship Song in the Two-Spotted Cricket, Gryllus bimaculatus.

  Atsushi Miyashita; Hayato Kizaki; Kazuhisa Sekimizu; Chikara Kaito

  PloS one  2016
• 16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus.

  Tatsuhiko Kyuma; Hayato Kizaki; Hiroki Ryuno; Kazuhisa Sekimizu; Chikara Kaito

  Biochimie  2015/12
• Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.

  Kenichi Ishii; Fumiaki Tabuchi; Miki Matsuo; Keita Tatsuno; Tomoaki Sato; Mitsuhiro Okazaki; Hiroshi Hamamoto; Yasuhiko Matsumoto; Chikara Kaito; Tetsuji Aoyagi; Keiichi Hiramatsu; Mitsuo Kaku; Kyoji Moriya; Kazuhisa Sekimizu

  Scientific reports  2015/11
• A novel mutation in the vraS gene of Staphylococcus aureus contributes to reduce susceptibility against daptomycin.

  Jie Su; Maki Iehara; Jyunichiro Yasukawa; Yasuhiko Matsumoto; Hiroshi Hamamoto; Kazuhisa Sekimizu

  The Journal of antibiotics  2015/10
• Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2015/08
• Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies.

  Kenichi Ishii; Hiroshi Hamamoto; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2015/08
• Niemann-Pick disease type C2 protein induces autophagy and inhibits growth in FM3A breast cancer cells.

  Tatsuo Adachi; Yasuhiko Matsumoto; Yoshinori Inagaki; Kazuhisa Sekimizu

  Drug discoveries & therapeutics  2015/08
• Ribosomal RNA methyltransferases contribute to Staphylococcus aureus virulence.

  Tatsuhiko Kyuma; Satoshi Kimura; Yuichi Hanada; Tsutomu Suzuki; Kazuhisa Sekimizu; Chikara Kaito

  The FEBS journal  2015/07

MISC

• カイコを用いた敗血症性サイトカインストーム機構モデルの構築

  関水和久; 三上雄大; YU Yidong; 李文淵; 宮下惇嗣; 石島早苗  日本生化学会大会(Web)  96th-  2023
• Innate immunity to microbial pathogens

  宮下惇嗣; 斎藤優; 藤本ゆかり; 新家一男; 関水和久  日本細菌学雑誌(Web)  78-  (1)  2023
• Construction of septic disseminated intravascular coagulation (DIC) model using the silkworm, Bombyx mori

  関水和久; 宮下惇嗣; LI Wenyuan; 三上雄大; YU Yidong; 浜本洋  日本薬学会年会要旨集(Web)  143rd-  2023
• Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret.

  Hiroshi Hamamoto; Atsushi Miyashita; Koushirou Kamura; Ryo Horie; Kazuhisa Sekimizu  Drug discoveries & therapeutics  16-  (6)  280  -285  2022/12
• Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus).

  Atsushi Miyashita; Kazuhisa Sekimizu; Chikara Kaito  Drug discoveries & therapeutics  16-  (5)  204  -209  2022/11
• Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220.

  Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Chikara Kaito; Yutaka Suzuki; Kazuhisa Sekimizu  Heliyon  8-  (11)  e11376  2022/11
• Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.

  Geberemichal Geberetsadik; Akane Inaizumi; Akihito Nishiyama; Takehiro Yamaguchi; Hiroshi Hamamoto; Suresh Panthee; Aki Tamaru; Manabu Hayatsu; Yusuke Mizutani; Shaban Amina Kaboso; Mariko Hakamata; Aleksandr Ilinov; Yuriko Ozeki; Yoshitaka Tateishi; Kazuhisa Sekimizu; Sohkichi Matsumoto  Antimicrobial agents and chemotherapy  66-  (9)  e0017122  2022/09
• Transcriptome change of Staphylococcus aureus in infected mouse liver.

  Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Suguru Ohgi; Yutaka Suzuki; Koichi Makimura; Kazuhisa Sekimizu  Communications biology  5-  (1)  721  -721  2022/07
• Peanut triacylglycerols activate innate immunity both in insects and mammals.

  Wenyuan Li; Atsushi Miyashita; Kazuhisa Sekimizu  Scientific reports  12-  (1)  7464  -7464  2022/05
• カイコ創薬最前線:ヒトバイオ医薬品生産・ヒト疾患モデル開発への展開 カイコを用いた過剰炎症モデルの作出と創薬研究への展望

  宮下 惇嗣; 関水 和久  日本薬学会年会要旨集  142年会-  S12  -5  2022/03
• 昆虫を用いた創薬プラットフォームの創成

  宮下惇嗣; 関水和久  日本生化学会大会(Web)  95th-  2022
• Cryptococcus neoformansの病原性因子の網羅的探索

  浜本洋; 石島早苗; PANTHEE Suresh; 関水和久  関東医真菌懇話会プログラム・抄録集  41st-  2022
• Cryptococcus neoformansの病原性発揮機構の網羅的な理解

  浜本洋; 石島早苗; 関水和久  日本医真菌学会雑誌  63-  (Supplement 1)  2022
• Establishment of a polymerase chain reaction-based method for strain-level management of Enterococcus faecalis EF-2001 using species-specific sequences identified by whole genome sequences.

  Hiroshi Hamamoto; Akihiko Ano Ogasawara; Masahiro Iwasa; Kazuhisa Sekimizu  Frontiers in microbiology  13-  959063  -959063  2022
• YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus.

  Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Tom Grunert; Kazuhisa Sekimizu  Virulence  12-  (1)  470  -480  2021/12
• An efficient method to screen for the soil bacteria producing therapeutically effective antibiotics.

  Hiroshi Hamamoto; Suresh Panthee; Kana Hashimoto; Toshio Tsuchida; Kazuhisa Sekimizu  The Journal of antibiotics  74-  (12)  850  -855  2021/12
• Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model.

  Suresh Panthee; Hiroshi Hamamoto; Yayoi Nishiyama; Atmika Paudel; Kazuhisa Sekimizu  Journal of fungi (Basel, Switzerland)  7-  (11)  2021/11
• Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus.

  Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Kenichi Ishii; Jyunichiro Yasukawa; Jie Su; Atsushi Miyashita; Hiroaki Itoh; Kotaro Tokumoto; Masayuki Inoue; Kazuhisa Sekimizu  Nature communications  12-  (1)  6364  -6364  2021/11
• A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies.

  Hiroto Nakajima; Atsushi Miyashita; Hiroshi Hamamoto; Kazuhisa Sekimizu  Scientific reports  11-  (1)  10757  -10757  2021/05
• Using silkworms to search for lactic acid bacteria that contribute to infection prevention and improvement of hyperglycemia.

  Atsushi Miyashita; Kazuhisa Sekimizu  Drug discoveries & therapeutics  15-  (2)  51  -54  2021/05
• Evaluation of pathogenicity and therapeutic effectiveness of antibiotics using silkworm Nocardia infection model.

  Kazuhiro Mikami; Kazunari Sonobe; Keiko Ishino; Takumi Noda; Mami Kato; Mami Hanao; Hiroshi Hamamoto; Kazuhisa Sekimizu; Mitsuhiro Okazaki  Drug discoveries & therapeutics  15-  (2)  73  -77  2021/05
• Complete genome sequence and comparative genomic analysis of Enterococcus faecalis EF-2001, a probiotic bacterium.

  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Akihiko Ano Ogasawara; Toshihiro Iwasa; Jochen Blom; Kazuhisa Sekimizu  Genomics  113-  (3)  1534  -1542  2021/05
• A digital scheme of human trials for the evaluation of functional foods.

  Atsushi Miyashita; Kazuyuki Shimomura; Hiroto Nakajima; Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  15-  (1)  9  -13  2021/03
• 転写伸長因子S-IIを標的とした真菌感染症治療薬

  宮下惇嗣; 松本靖彦; 山田剛; 清水公徳; 成瀬啓樹; 本間誠之; 巻秀樹; 川本進; 関水和久  日本医真菌学会雑誌  62-  (Supplement 1)  106  -106  2021
• 生物間相互作用に基づくカイコ創薬

  宮下惇嗣; 関水和久; 関水和久  日本生化学会大会(Web)  94th-  [2S06e  -03]  2021
• Applying the silkworm model for the search of immunosuppressants.

  Atsushi Miyashita; Hiroshi Hamamoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  15-  (3)  139  -142  2021
• Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library.

  Yuri Takada; Hiroaki Itoh; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue  Nature communications  11-  (1)  4935  -4935  2020/10
• A simple artificial diet available for research of silkworm disease models.

  Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  14-  (4)  177  -180  2020/09
• カンジダの発育抑制活性を示すココナッツ油およびリパーゼ含有歯磨き剤開発の試み

  羽山 和美; 二宮 健太郎; 関水 和久; 安部 茂  日本医真菌学会雑誌  61-  (Suppl.)  81  -81  2020/09
• Large-Scale Screening and Identification of Novel Pathogenic Staphylococcus aureus Genes Using a Silkworm Infection Model.

  Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Yasuhiko Matsumoto; Kazuhisa Sekimizu  The Journal of infectious diseases  221-  (11)  1795  -1804  2020/05
• Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter.

  Chikara Kaito; Hirono Yoshikai; Ai Wakamatsu; Atsushi Miyashita; Yasuhiko Matsumoto; Tomoko Fujiyuki; Masaru Kato; Yoshitoshi Ogura; Tetsuya Hayashi; Takao Isogai; Kazuhisa Sekimizu  PLoS pathogens  16-  (4)  e1008469  2020/04
• Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells.

  Yasuhiko Matsumoto; Miki Takahashi; Kazuhisa Sekimizu  Drug discoveries & therapeutics  14-  (1)  8  -13  2020
• The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus.

  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Anne-Catrin Uhlemann; Kazuhisa Sekimizu  Frontiers in microbiology  11-  2076  -2076  2020
• GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus.

  Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu  RSC advances  9-  (65)  37889  -37894  2019/11
• Suppressive effects of whey protein hydrolysate on sucrose-induced hyperglycemia in silkworms.

  Yasuhiko Matsumoto; Miki Takahashi; Masahiro Umehara; Masato Asano; Hiroko Maruki-Uchida; Minoru Morita; Kazuhisa Sekimizu  Drug discoveries & therapeutics  13-  (5)  244  -247  2019/11
• Candida albicans発育に及ぼす乳酸菌死菌体と発酵β-グルカン誘導腹腔内細胞の組み合わせの効果

  羽山 和美; 鈴木 基文; 久下 高生; 岩佐 広行; 安部 茂; 関水 和久  日本医真菌学会雑誌  60-  (Suppl.1)  101  -101  2019/10
• 白癬菌汚染した靴を揮発性の抗菌アロマ成分を用いて除菌する実用法の開発(インソール;靴中敷)

  石島 早苗; 比留間 政太郎; 大島 浩智; 鈴木 修; 江澤 邦夫; 関水 和久; 安部 茂  日本医真菌学会雑誌  60-  (Suppl.1)  86  -86  2019/10
• Cryptococcus neoformansのマウス感染状態における網羅的遺伝子発現解析

  浜本 洋; スレス・パンシー; アトミカ・パウデル; 石島 早苗; 関水 和久  日本医真菌学会雑誌  60-  (Suppl.1)  87  -87  2019/10
• Identification of 2H phosphoesterase superfamily proteins with 2'-CPDase activity.

  Shuhei Mitsutomi; Nobuyoshi Akimitsu; Kazuhisa Sekimizu; Chikara Kaito  Biochimie  165-  235  -244  2019/10
• Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment.

  Daniel Don Nwibo; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  13-  (3)  145  -149  2019/07
• Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E.

  Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue  Nature communications  10-  (1)  2992  -2992  2019/07
• Pharmacokinetics of anti-infectious reagents in silkworms.

  Hiroshi Hamamoto; Ryo Horie; Kazuhisa Sekimizu  Scientific reports  9-  (1)  9451  -9451  2019/07
• Silkworm as an experimental animal for research on fungal infections.

  Yasuhiko Matsumoto; Kazuhisa Sekimizu  Microbiology and immunology  63-  (2)  41  -50  2019/02
• Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans.

  Yasuhiko Matsumoto; Masaki Ishii; Setsuo Hasegawa; Kazuhisa Sekimizu  Communications biology  2-  157  -157  2019
• Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph.

  Hiroki Ryuno; Fuki Nigo; Isao Naguro; Kazuhisa Sekimizu; Chikara Kaito  PloS one  14-  (5)  e0217517  2019
• Additive effects of Kothala himbutu (Salacia reticulata) extract and a lactic acid bacterium (Enterococcus faecalis YM0831) for suppression of sucrose-induced hyperglycemia in an in vivo silkworm evaluation system.

  Masaki Ishii; Yasuhiko Matsumoto; Toshiaki Katada; Kazuhisa Sekimizu  Drug discoveries & therapeutics  13-  (3)  133  -136  2019
• Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis.

  Suresh Panthee; Atmika Paudel; Jochen Blom; Hiroshi Hamamoto; Kazuhisa Sekimizu  Frontiers in microbiology  10-  1619  -1619  2019
• Detection of Trichophyton spp. from footwear of patients with tinea pedis.

  Sanae A Ishijima; Masataro Hiruma; Kazuhisa Sekimizu; Shigeru Abe  Drug discoveries & therapeutics  13-  (4)  207  -211  2019
• 乳酸菌加熱死菌体と発酵βグルカン誘導腹腔内細胞の組み合わせによるCandida albicans菌糸形発育の阻止

  羽山 和美; 鈴木 基文; 久下 高生; 岩佐 広行; 関水 和久; 安部 茂  Medical Mycology Research  9-  (1)  3  -8  2018/12
• Bacterial polysaccharides inhibit sucrose-induced hyperglycemia in silkworms.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  12-  (4)  185  -188  2018/09
• Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 1768.

  Suresh Panthee; Hiroshi Hamamoto; Sanae A Ishijima; Atmika Paudel; Kazuhisa Sekimizu  Genome biology and evolution  10-  (8)  2017  -2022  2018/08
• Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.

  Tomohiro Maruyama; Takashi Baba; Yuki Maemoto; Chikako Hara-Miyauchi; Minami Hasegawa-Ogawa; Hirotaka James Okano; Yuki Enda; Kei Matsumoto; Nagisa Arimitsu; Kazuki Nakao; Hiroshi Hamamoto; Kazuhisa Sekimizu; Takayo Ohto-Nakanishi; Hiroki Nakanishi; Takeshi Tokuyama; Shigeru Yanagi; Mitsuo Tagaya; Katsuko Tani  Cell death & disease  9-  (8)  797  -797  2018/07
• Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic.

  Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue  The Journal of organic chemistry  83-  (13)  6924  -6935  2018/07
• Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model.

  Atmika Paudel; Suresh Panthee; Makoto Urai; Hiroshi Hamamoto; Tomohiko Ohwada; Kazuhisa Sekimizu  Scientific reports  8-  (1)  1578  -1578  2018/01
• Estimation of lactic acid bacterial cell number by DNA quantification.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  12-  (2)  88  -91  2018
• [Platform Development for Drug Discovery Utilizing Silkworm towards "Novel Industrial Revolution"].

  Kazuhisa Sekimizu; Kohji Itoh  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  138-  (7)  861  -862  2018
• [Development of Antibiotics Using Silkworm Bacteria and Fungi Infection Model].

  Hiroshi Hamamoto; Kazuhisa Sekimizu  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  138-  (7)  895  -899  2018
• Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation system.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  12-  (3)  122  -125  2018
• Establishment of a gnotobiotic silkworm model.

  Hiroto Nakajima; Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  12-  (5)  291  -294  2018
• 昆虫モデルを用いた緑膿菌感染に対するプロバイオティクス効果の解析

  西田 智; 関水 和久; 斧 康雄  緑膿菌感染症研究会講演記録  51回-  80  -83  2017/12
• 昆虫モデルを用いた緑膿菌感染に対するプロバイオティクス効果の解析

  西田智; 関水和久; 関水和久; 斧康雄  緑膿菌感染症研究会講演記録  51st-  80‐83  -83  2017/12
• In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms.

  Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi  Pharmaceutical biology  55-  (1)  1256  -1262  2017/12
• Structural analysis of an innate immunostimulant from broccoli, Brassica oleracea var. italica.

  Makoto Urai; Keiko Kataoka; Satoshi Nishida; Kazuhisa Sekimizu  Drug discoveries & therapeutics  11-  (5)  230  -237  2017/11
• Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from Rhizobium sp. strain M2 screened using a silkworm muscle contraction assay.

  Makoto Urai; Tomoko Aizawa; Katsutoshi Imamura; Hiroshi Hamamoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  11-  (5)  238  -245  2017/11
• Two-spotted cricket as an animal infection model of human pathogenic fungi.

  Yuto Kochi; Yasuhiko Matsumoto; Kazuhisa Sekimizu; Chikara Kaito  Drug discoveries & therapeutics  11-  (5)  259  -266  2017/11
• Isolation of antibiotic-producing Pseudomonas species with low-temperature cultivation of temperate soil.

  Shuhei Mitsutomi; Kazuhisa Sekimizu; Chikara Kaito  Drug discoveries & therapeutics  11-  (5)  267  -275  2017/11
• Evaluation of the innate immune-stimulating activity of amazake using a silkworm muscle contraction assay.

  Hiroko Maruki-Uchida; Masahiko Sai; Kazuhisa Sekimizu  Drug discoveries & therapeutics  11-  (5)  288  -290  2017/11
• An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis.

  Masaki Ishii; Yasuhiko Matsumoto; Tsuyoshi Yamada; Shigeru Abe; Kazuhisa Sekimizu  Scientific reports  7-  (1)  12289  -12289  2017/09
• Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions.

  Haruka Fujino; Masanori Nagatomo; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue  Angewandte Chemie (International ed. in English)  56-  (39)  11865  -11869  2017/09
• D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus.

  Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu  The Journal of antibiotics  70-  (8)  907  -910  2017/07
• Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus.

  Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu  The Journal of antibiotics  70-  (6)  771  -774  2017/06
• Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b.

  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu  Genome announcements  5-  (22)  2017/06
• Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori).

  Kantaporn Kheawfu; Surachai Pikulkaew; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi  Drug discoveries & therapeutics  11-  (2)  64  -69  2017/05
• Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract.

  Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi  Drug discoveries & therapeutics  11-  (2)  70  -77  2017/05
• Genomic analysis of vancomycin-resistant Staphylococcus aureus VRS3b and its comparison with other VRSA isolates.

  Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Kazuhisa Sekimizu  Drug discoveries & therapeutics  11-  (2)  78  -83  2017/05
• Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis.

  Akiho Yagi; Ryuji Uchida; Hiroshi Hamamoto; Kazuhisa Sekimizu; Ken-Ichi Kimura; Hiroshi Tomoda  The Journal of antibiotics  70-  (5)  685  -690  2017/05
• Lactic acid bacteria of the Leuconostoc genus with high innate immunity-stimulating activity.

  Masaki Ishii; Satoshi Nishida; Keiko Kataoka; Yayoi Nishiyama; Shigeru Abe; Kazuhisa Sekimizu  Drug discoveries & therapeutics  11-  (1)  25  -29  2017/03
• Decreased sugar concentration in vegetable and fruit juices by growth of functional lactic acid bacteria.

  Masaki Ishii; Yasuhiko Matsumoto; Satoshi Nishida; Kazuhisa Sekimizu  Drug discoveries & therapeutics  11-  (1)  30  -34  2017/03
• Silkworm fungal infection model for identification of virulence genes in pathogenic fungus and screening of novel antifungal drugs.

  Masaki Ishii; Yasuhiko Matsumoto; Ikuko Nakamura; Kazuhisa Sekimizu  Drug discoveries & therapeutics  11-  (1)  1  -5  2017/03
• In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-5.

  Suresh Panthee; Hiroshi Hamamoto; Yutaka Suzuki; Kazuhisa Sekimizu  The Journal of antibiotics  70-  (2)  204  -207  2017/02
• Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection.

  Ikuko Nakamura; Ryuichi Kanasaki; Koji Yoshikawa; Shigetada Furukawa; Akihiko Fujie; Hiroshi Hamamoto; Kazuhisa Sekimizu  The Journal of antibiotics  70-  (1)  41  -44  2017/01
• Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents.

  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu  Frontiers in microbiology  8-  373  -373  2017
• Lactobacillus paraplantarum 11-1 Isolated from Rice Bran Pickles Activated Innate Immunity and Improved Survival in a Silkworm Bacterial Infection Model.

  Satoshi Nishida; Masaki Ishii; Yayoi Nishiyama; Shigeru Abe; Yasuo Ono; Kazuhisa Sekimizu  Frontiers in microbiology  8-  436  -436  2017
• [Development of Novel Antibiotic Lysocin E Identified by Silkworm Infection Model].

  Hiroshi Hamamoto; Kazuhisa Sekimizu  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  137-  (4)  389  -392  2017
• [The Usefulness of Silkworms as a Model Animal for Evaluating the Effectiveness of Medicine and Food].

  Kazuhisa Sekimizu  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  137-  (5)  551  -562  2017
• A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus.

  Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Keiichi Kaneko; Shigeki Matsunaga; Motomu Kanai; Yutaka Suzuki; Kazuhisa Sekimizu  Frontiers in microbiology  8-  712  -712  2017
• [A Silkworm Infection Model to Evaluate Antifungal Drugs for Cryptococcosis].

  Yasuhiko Matsumoto; Masaki Ishii; Kiminori Shimizu; Susumu Kawamoto; Kazuhisa Sekimizu  Medical mycology journal  58-  (4)  E131-E137  2017
• 昆虫を用いた緑膿菌感染モデルにおける乳酸菌による感染死抑制効果

  西田智; 斧康雄; 関水和久; 関水和久  緑膿菌感染症研究会講演記録  50回-  112  -118  2016/12
• Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity.

  Takuya Kaji; Motoki Murai; Hiroaki Itoh; Jyunichiro Yasukawa; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue  Chemistry (Weinheim an der Bergstrasse, Germany)  22-  (47)  16912  -16919  2016/11
• Lysobacter species: a potential source of novel antibiotics.

  Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Kazuhisa Sekimizu  Archives of microbiology  198-  (9)  839  -45  2016/11
• A silkworm infection model to investigate Vibrio vulnificus virulence genes.

  Mai Yamamoto; Takashige Kashimoto; Yukihiro Yoshimura; Nao Tachibana; Shiho Kuroda; Yoshiko Miki; Sou Kitabayashi; Ping Tong; Jianbo Xiao; Koichi Tanaka; Hiroshi Hamamoto; Kazuhisa Sekimizu; Koichiro Yamamoto  Molecular medicine reports  14-  (5)  4243  -4247  2016/11
• Novel Nucleoside Diphosphatase Contributes to Staphylococcus aureus Virulence.

  Kenta Imae; Yuki Saito; Hayato Kizaki; Hiroki Ryuno; Han Mao; Atsushi Miyashita; Yutaka Suzuki; Kazuhisa Sekimizu; Chikara Kaito  The Journal of biological chemistry  291-  (36)  18608  -18619  2016/09
• A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus.

  Yuto Kochi; Atsushi Miyashita; Kohsuke Tsuchiya; Masao Mitsuyama; Kazuhisa Sekimizu; Chikara Kaito  FEMS microbiology letters  363-  (15)  2016/08
• Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus.

  Atsushi Miyashita; Hayato Kizaki; Kazuhisa Sekimizu; Chikara Kaito  Biology open  5-  (6)  770  -6  2016/06
• An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia.

  Yasuhiko Matsumoto; Masaki Ishii; Kazuhisa Sekimizu  Scientific reports  6-  26354  -26354  2016/05
• 乳酸菌によるカイコの細菌感染死の抑制

  西田 智; 斧 康雄; 関水 和久  感染症学雑誌  90-  (3)  434  -435  2016/05
• A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus.

  Yasuhiko Matsumoto; Jyunichiro Yasukawa; Masaki Ishii; Yohei Hayashi; Shinya Miyazaki; Kazuhisa Sekimizu  Scientific reports  6-  22894  -22894  2016/03
• Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (1)  9  -13  2016/02
• A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine.

  Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (1)  14  -8  2016/02
• Identification of lysocin E using a silkworm model of bacterial infection.

  Hiroshi Hamamoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (1)  24  -9  2016/02
• Evaluation of anti-diabetic drugs by using silkworm, Bombyx mori.

  Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (1)  19  -23  2016/02
• Using silkworms as a laboratory animal to evaluate medicines and foods.

  Kazuhisa Sekimizu; Hiroshi Hamamoto  Drug discoveries & therapeutics  10-  (1)  1  -2  2016/02
• Using silkworms to establish alternative animal models for evaluation of drug-induced tissue injury.

  Yoshinori Inagaki; Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (1)  40  -3  2016/02
• Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm.

  Satoshi Nishida; Yasuo Ono; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (1)  49  -56  2016/02
• Acute oral toxicity test of chemical compounds in silkworms.

  Kimihito Usui; Satoshi Nishida; Takuya Sugita; Takuro Ueki; Yasuhiko Matsumoto; Hidenobu Okumura; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (1)  57  -61  2016/02
• Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins.

  Hirono Yoshikai; Hayato Kizaki; Yuki Saito; Yosuke Omae; Kazuhisa Sekimizu; Chikara Kaito  The Journal of infectious diseases  213-  (2)  295  -304  2016/01
• An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces.

  Masakazu Nakadai; Shuta Tomida; Kazuhisa Sekimizu  Scientific reports  6-  18543  -18543  2016/01
• No Effect of Body Size on the Frequency of Calling and Courtship Song in the Two-Spotted Cricket, Gryllus bimaculatus.

  Atsushi Miyashita; Hayato Kizaki; Kazuhisa Sekimizu; Chikara Kaito  PloS one  11-  (1)  e0146999  2016
• Menaquinone as a potential target of antibacterial agents.

  Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (3)  123  -8  2016
• Dividing phase-dependent cytotoxicity profiling of human embryonic lung fibroblast identifies candidate anticancer reagents.

  Yoshinori Inagaki; Yasuhiko Matsumoto; Wei Tang; Kazuhisa Sekimizu  Drug discoveries & therapeutics  10-  (4)  195  -200  2016
• Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading.

  Hayato Kizaki; Yosuke Omae; Fumiaki Tabuchi; Yuki Saito; Kazuhisa Sekimizu; Chikara Kaito  PloS one  11-  (10)  e0164523  2016
• 16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus.

  Tatsuhiko Kyuma; Hayato Kizaki; Hiroki Ryuno; Kazuhisa Sekimizu; Chikara Kaito  Biochimie  119-  166  -74  2015/12
• Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.

  Kenichi Ishii; Fumiaki Tabuchi; Miki Matsuo; Keita Tatsuno; Tomoaki Sato; Mitsuhiro Okazaki; Hiroshi Hamamoto; Yasuhiko Matsumoto; Chikara Kaito; Tetsuji Aoyagi; Keiichi Hiramatsu; Mitsuo Kaku; Kyoji Moriya; Kazuhisa Sekimizu  Scientific reports  5-  17092  -17092  2015/11
• A novel mutation in the vraS gene of Staphylococcus aureus contributes to reduce susceptibility against daptomycin.

  Jie Su; Maki Iehara; Jyunichiro Yasukawa; Yasuhiko Matsumoto; Hiroshi Hamamoto; Kazuhisa Sekimizu  The Journal of antibiotics  68-  (10)  646  -8  2015/10
• Niemann-Pick disease type C2 protein induces autophagy and inhibits growth in FM3A breast cancer cells.

  Tatsuo Adachi; Yasuhiko Matsumoto; Yoshinori Inagaki; Kazuhisa Sekimizu  Drug discoveries & therapeutics  9-  (4)  282  -8  2015/08
• Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies.

  Kenichi Ishii; Hiroshi Hamamoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  9-  (4)  238  -46  2015/08
• Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity.

  Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu  Drug discoveries & therapeutics  9-  (4)  234  -7  2015/08
• Ribosomal RNA methyltransferases contribute to Staphylococcus aureus virulence.

  Tatsuhiko Kyuma; Satoshi Kimura; Yuichi Hanada; Tsutomu Suzuki; Kazuhisa Sekimizu; Chikara Kaito  The FEBS journal  282-  (13)  2570  -84  2015/07
• カイコを利用する創薬イノベーションと未来 カイコモデルを用いた治療効果を有する新規抗菌薬の同定と開発

  浜本 洋; 石井 健一; 安川 淳一朗; 西田 智; 関水 和久  日本薬学会年会要旨集  135年会-  (1)  150  -150  2015/03
• 黄色ブドウ球菌のHMG-CoAレダクターゼのペプチドグリカン合成における役割

  松本靖彦; 安川淳一郎; 石井雅樹; 林陽平; 宮崎真也; 関水和久  日本ブドウ球菌研究会プログラム・講演要旨集  60th-  2015
• 糖尿病宿主に対する病原性因子であるHdvAタンパク質はHbpタンパク質と複合体を形成し,黄色ブドウ球菌のGlcNAc-malを脱アセチル化する

  石井雅樹; 松本靖彦; 林陽平; 宮崎真也; 坂上徹; 垣内力; 関水和久  微生物シンポジウム講演要旨集  27th-  2015
• カイコをモデル宿主とする自然免疫・感染症研究の最前線:─昆虫サイトカインParalytic peptideの機能解明を中心に─

  石井 健一; 浜本 洋; 関水 和久  Journal of Insect Biotechnology and Sericology  84-  (3)  3_173  -3_179  2015
• カイコを用いた創薬研究

  松本靖彦; 浜本洋; 西田智; 関水和久  生体の科学  65-  (6)  613  -620  2014/12  [Invited]
  
• 新規抗生物質カイコシンEの治療効果の基礎となる分子メカニズム

  安川淳一朗; 浜本洋; ジー スー; パウデル アトミカ; 浦井誠; 西田智; 関水和久  日本生化学会大会(Web)  87th-  4T13A-09(3P-023) (WEB ONLY)  -09]  2014/10
• 血清因子による新規抗生物質カイコシンの抗菌活性促進

  安川淳一朗; 浜本洋; SU Jie; ATMIKA Paudel; 浦井誠; 石井健一; 安達健朗; 西田智; 関水和久  日本細菌学雑誌  69-  (1)  135  -135  2014/02
• 糖尿病宿主に対する黄色ブドウ球菌の感染におけるグルコース応答機構の役割

  石井雅樹; 松本靖彦; 林陽平; 宮崎真也; 坂上徹; 垣内力; 関水和久  日本細菌学雑誌  69-  (1)  2014
• 糖尿病宿主環境に適応するための黄色ブドウ球菌のヘム取り込み機構の役割

  松本靖彦; 宮崎真也; 林陽平; 石井雅樹; 坂上徹; 垣内力; 関水和久  微生物シンポジウム講演要旨集  26th-  2014
• 黄色ブドウ球菌のGlcNAc-mal脱アセチル化酵素は高血糖宿主に対する病原性に必要である

  石井雅樹; 松本靖彦; 林陽平; 宮崎真也; 坂上徹; 垣内力; 関水和久  日本生化学会大会(Web)  87th-  2014
• 黄色ブドウ球菌のGlcNAc-mal脱アセチル化活性は高血糖宿主に対する病原性に必要である

  石井雅樹; 松本靖彦; 林陽平; 宮崎真也; 坂上徹; 垣内力; 関水和久  日本ブドウ球菌研究会プログラム・講演要旨集  59th-  2014
• Evaluation of lactic acid bacteria activating innate immunity using silkworm

  NISHIDA Satoshi; ISHII Kennichi; HAMAMOTO Hiroshi; SEKIMIZU Kazuhisa; SEKIMIZU Kazuhisa  Alternatives to Animal Testing and Experimentation  19-  (Supplement)  2014
• 黄色ブドウ球菌の病原性に寄与する新規ヌクレオシド二リン酸分解酵素の同定

  宮下惇嗣; 今江健太; 木崎速人; 斎藤祐樹; 毛瀚; 関水和久; 垣内力  日本生化学会大会(Web)  87th-  [4T08p  -04]  2014
• rRNAのメチル化による翻訳忠実性の維持が黄色ブドウ球菌の病原性に寄与する

  久間 達彦; 木村 聡; 鈴木 勉; 関水 和久; 垣内 力  日本生化学会大会プログラム・講演要旨集  86回-  3T14a  -13  2013/09
• カイコ細菌感染モデルを用いた治療有効な新規抗生物質カイコシンの作用機序解析

  安川淳一朗; 浜本洋; SU Jie; PAUDEL Atmika; 浦井誠; 西田智; 関水和久  日本生化学会大会(Web)  86回-  2T19a  -05  2013/09
• 新規機能性RNA psm-mecはagrA遺伝子の翻訳を抑制してメチシリン耐性黄色ブドウ球菌の病原性を抑制する

  幾尾 真理子; 齋藤 裕樹; 大前 陽輔; 毛 瀚; 長野 源太郎; 藤幸 知子; 沼田 俊介; 韓 笑; 小幡 佳津明; 長谷川 節雄; 山口 博樹; 猪口 孝一; 伊藤 輝代; 平松 啓一; 伊藤 孝司; 関水 和久; 垣内 力  日本生化学会大会プログラム・講演要旨集  86回-  3T14a  -14  2013/09
• カイコを用いた新規医薬品と評価システムの開発 カイコ病態モデルを利用した医薬品の探索研究

  浜本 洋; 石川 繭子; 瀬筒 秀樹; 坪田 拓也; 片岡 啓子; 松本 靖彦; 垣内 力; 関水 和久  日本薬学会年会要旨集  133年会-  (1)  178  -178  2013/03
• 黄色ブドウ球菌のグルコース応答を介した病原性調節機構

  石井雅樹; 松本靖彦; 林陽平; 宮崎真也; 坂上徹; 垣内力; 関水和久  日本ブドウ球菌研究会プログラム・講演要旨集  58th-  2013
• 黄色ブドウ球菌のグルコース応答システムを介した病原性発揮機構

  石井雅樹; 松本靖彦; 林陽平; 宮崎真也; 坂上徹; 垣内力; 関水和久  次世代を担う若手ファーマ・バイオフォーラム講演要旨集  12th-  2013
• Niemann-Рick disease type C2タンパク質は脂肪蓄積を促進する

  安達健朗; 石井健一; 松本靖彦; 林陽平; 浜本洋; 関水和久  生体膜と薬物の相互作用シンポジウム講演要旨集  35th-  2013
• Development of an alternative method of acute oral toxicity tests using silkworm Part 2

  SUGITA Takuya; YAMAMOTO Yutaka; UEKI Takuro; NISHIDA Satoshi; HAMAMOTO Hiroshi; MATSUMOTO Yasuhiko; SEKIMIZU Kazuhisa; SEKIMIZU Kazuhisa; OKUMURA Hidenobu  Alternatives to Animal Testing and Experimentation  18-  (Supplement)  2013
• 無脊椎動物における適応免疫機構

  宮下惇嗣; 川崎清史; 関水和久; 垣内力  日本生化学会大会(Web)  86th-  1T18p  -02  2013
• カイコにおいてリポ多糖を認識するブースター反応が感染防御に寄与する

  宮下惇嗣; 関水和久; 垣内力  日本細菌学雑誌  68-  (1)  204  -204  2013
• LPSトランスポーターの変異による大腸菌の高病原性化

  吉海周; 若松愛; 若松愛; 宮下惇嗣; 松本靖彦; 磯貝隆夫; 関水和久; 垣内力  日本生化学会大会(Web)  86th-  1T18p  -01  2013
• 高血糖カイコ感染モデルによる糖尿病宿主に対する病原性に必要な細菌の遺伝子の同定

  宮崎 真也; 松本 靖彦; 林 陽平; 坂上 徹; 垣内 力; 龍野 桂太; 岡崎 充宏; 奥川 周; 森屋 恭爾; 関水 和久  日本細菌学雑誌  67-  (1)  105  -105  2012/02
• 黄色ブドウ球菌のHMG-CoAレダクターゼの活性は基質によるアロステリック制御を受ける

  安川淳一朗; 松本靖彦; 林陽平; 宮崎真也; 関水和久  日本生化学会大会(Web)  85th-  2012
• 黄色ブドウ球菌のヘム取り込み機構は,糖尿病状態の宿主に感染するために必要である

  松本靖彦; 宮崎真也; 林陽平; 石井雅樹; 坂上徹; 垣内力; 関水和久  日本ブドウ球菌研究会プログラム・講演要旨集  57th-  2012
• none

  Keigo UENO; Yasuhiko MATSUMOTO; Kazuhisa SEKIMIZU; Yuki KINJO; Hiroji CHIBANA  KAGAKU TO SEIBUTSU  50-  (5)  320  -321  2012  [Invited]
  
• セラチア菌のO抗原によるカイコ血球細胞の細胞死誘導

  石井健一; 臼井公人; 今村亮俊; 浜本洋; 鈴木一史; 渡邉剛志; 関水和久  生化学  2010
• Evaluation of anti-diabetic drugs using silkworm, Bombyx mori.

  Yasuhiko Matsumoto; Eriko Sumiya; Takuya Sugita; Kazuhisa Sekimizu  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN  128-  87  -87  2008
• 哺乳動物細胞における,DNA topoisomerase IIαの活性低下によるアポトーシスの誘導

  嘉村 格士郎; 秋光 信佳; 刀祢 重信; 阪口 亜矢子; 菊池 韶彦; 浜本 洋; 関水 和久  日本薬学会年会要旨集  123年会-  (3)  132  -132  2003/03
• ノックアウトマウスを用いたグライコフォリンAの生体内機能に関する研究

  有光 なぎさ; 秋光 信佳; 浜本 洋; 関水 和久  日本薬学会年会要旨集  121年会-  (4)  21  -21  2001/03
• 黄色ブドウ球菌DnaA蛋白質の精製に関する研究

  嘉村 格士郎; 秋光 信佳; 片山 秀樹; 松尾 美記; 関水 和久  日本薬学会年会要旨集  121年会-  (4)  51  -51  2001/03
• 赤血球へのマウスマラリア原虫の侵入におけるDuffy蛋白質の役割に関する研究

  福間 信子; 秋光 信佳; 金 惠淑; 小野 華奈子; 有光 なぎさ; 浜本 洋; 綿矢 有佑; 関水 和久  日本薬学会年会要旨集  121年会-  (4)  78  -78  2001/03
• 黄色ブドウ球菌dnaB遺伝子の温度感受性変異株の分離

  垣内 力; 井上 隆一; 田邊 舞子; Hossain Muktadir Shahid; 洞田 佳範; 秋光 信佳; 関水 和久  日本薬学会年会要旨集  121年会-  (4)  52  -52  2001/03
• P176 Study of essential erythroid proteins for rodent malaria invasion

  AKIMITSU Nobuyoshi; KIM Hye-Sook; FUKUMA Nobuko; ARIMITSU Nagisa; ONO Kanako; HAMAMOTO Hiroshi; WATAYA Yusuke; SEKIMIZU Kazuhisa  Med. Entomol. Zool.  52-  (0)  121  -121  2001
• ヒト末梢血白血球におけるHSP70の誘導に関する研究

  下山 真智子; 秋光 信佳; 浜本 洋; 関水 和久  日本薬学会年会要旨集  120年会-  (4)  79  -79  2000/03
• 細胞接触によるES細胞のアポトーシスの抑制に関する研究

  大場 暁子; 秋光 信佳; 関水 和久  生化学  70-  (8)  943  -943  1998/08
• MRSAの消毒剤耐性変異の獲得によるβ-ラクタム系抗生物質に対する耐性度の上昇

  庄子 幹郎; 浜本 洋; 竹森 紘一; 濱崎 直孝; 赤峰 昭文; 秋光 信佳; 関水 和久  日本薬学会年会要旨集  118年会-  (3)  158  -158  1998/03

Research Grants & Projects

• 食品由来の強力な自然免疫活性化能を示す新規物質の作用機序解析

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2021/04 -2024/03 

  Author : 関水 和久; 宮下 惇嗣; 浜本 洋
• Comprehensive analysis of pathogenic ncRNA in host environment

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2017/10 -2020/03 

  Author : 関水 和久; PANTHEE SURESH
• Platform for the identification of novel therapeutically effective antimicrobial agents

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2015/05 -2020/03 

  Author : Kazuhisa Sekimizu
• Comprehensive understanding of bacterial adaptation mechanism in diabetic host

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2014/04 -2017/03 

  Author : Matsumoto Yasuhiko; SEKIMIZU KAZUHISA
• 治療効果を指標に同定された新規抗菌薬の作用機序解析

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2013/04 -2015/03 

  Author : 関水 和久; PAUDEL Atmika
• 新規リポペプチド系抗生物質カイコシンの標的同定

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2012/04 -2014/03 

  Author : 関水 和久
• Establishment of screening system for antifungal drugs using silkworm fungus infection model

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2014/03 

  Author : SEKIMIZU Kazuhisa; HAMAMOTO Hiroshi
• Understanding of host-pathogen interaction by using silkworm infection model

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011/04 -2014/03 

  Author : SEKIMIZU Kazuhisa; KAITO Chikara; MATSUMOTO Yasuhiko
• Development of novel molecular-targeted medicine against aminopeptidase

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2009 -2011 

  Author : KARAKO Takashi; KOKUDO Norihiro; SEKIMIZU Kazuhisa; NAKATA Munehiro
• 新規病原性遺伝子群を基盤とする病原性発現コアシステムの把握

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2009 -2010 

  Author : 関水 和久
• Elucidation of bacterial pathogenesis system based on a silkworm infection model

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2008 -2010 

  Author : SEKIMIZU Kazuhisa; KAITO Chikara
• 肝細胞がん特有の進行メカニズムに着目した新規化学療法剤の開発

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2008 -2009 

  Author : 唐子 堯; 國土 典宏; 関水 和久; 中田 宗宏
• カイコ感染モデルを用いたグラム陽性細菌に保存された病原性発現機構の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2007 -2008 

  Author : 関水 和久; 垣内 力
• 黄色ブドウ球菌の滑走能低下を指標とした抗菌治療薬に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2007 -2007 

  Author : 関水 和久; 伊藤 貴浩; 垣内 力
• カイコ幼虫における薬物動態に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2005 -2006 

  Author : 関水 和久
• ヒトに対する病原性細菌の感染モデルとしてのカイコ幼虫の有用性に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2003 -2003 

  Author : 関水 和久
• Functions of transcription elongation factor S-II for cell stress response and development

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2002 -2003 

  Author : SEKIMIZU Kazuhisa; ITOH Takahiro
• マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2002 -2003 

  Author : 関水 和久; 伊藤 貴浩; 黒川 健児; 秋光 信佳
• マウス初期胚におけるDNAトポイソメラーゼII依存チェックポイント機能低下の可能性

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2002 -2002 

  Author : 関水 和久; 秋光 信佳
• マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2001 -2001 

  Author : 関水 和久; 秋光 信佳
• 消毒剤耐性変異の獲得に伴うMRSAのβラクタム系抗生物質耐性の上昇

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2000 -2001 

  Author : 関水 和久; 久保 健雄
• Development of antibiotics by monitoring the inhibition of the ATP-binding to DnaA, the initiator protein of chromosomal DNA replication in bacteria

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2000 -2001 

  Author : SEKIMIZU Kazuhisa
• Study of the regulatory mechanism of DnaA protein, the initiator of DNA replication in Escherichia coli.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1999 -2000 

  Author : SEKIMIZU Kazuhisa; KUBO Takeo
• Interaction between the replicational initiator DnaA and the DNA polymerase components

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1998 -1999 

  Author : KATAYAMA Tsutomu; MIKI Takeyoshi; SEKIMIZU Kazuhisa
• Development of Anti-malarial Drug and it's Molecular Target

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1996 -1999 

  Author : WATAYA Yusuke; KITA Kiyoshi; ITAI Akiko; MATSUDA Akira; SEKIMIZU Kazuhisa; KIMURA Masatsugu; MORIYAMA Yoshiuori
• Molecular design of inhibitors for DNA replication in Escherichia coli

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1997 -1998 

  Author : SEKIMIZU Kazuhisa; MIKI Takeyoshi; SASAKI Shigeki
• マウス個体レベルでの分子シャペロンのDNA超ら旋構造調節に関する分子

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1997 -1997 

  Author : 関水 和久; 勝木 元也
• 染色体の複製開始の頻度と同時性の制御装置

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1997 -1997 

  Author : 片山 勉; 三木 健良; 関水 和久
• ストレス誘導性のDNAトポロジー変化のヒト細胞での解析

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1996 -1997 

  Author : 関水 和久; 早川 浩
• Changes of DNA supercoiling in Escherichia coli induced by stress

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1996 -1997 

  Author : SEKIMIZU Kazuhisa
• 大腸菌DnaAタンパク質機能の制御装置の分子機構

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1996 -1996 

  Author : 片山 勉; 水島 徹; 関水 和久
• Screening of inhibitors of DNA replication by using the oriC plasmid replication system of Escherichia coli

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1994 -1996 

  Author : SEKIMIZU Kazuhisa; KOBAYAKAWA Takahiro; SASAKI Shigetaka; MIKI Takeyoshi
• Biochemical and genetic study of the regulatory mechanism of the chromosomal DNA replication in Escherichia coli

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1994 -1995 

  Author : SEKIMIZU Kazuhisa; MIKI Takeyoshi
• Principle of Stress Response

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1993 -1995 

  Author : YAHARA Ichiro; SEKIMIZU Kazuhisa; NAKAMURA Yoshikazu; SHINAGAWA Hideo; ITO Koreaki; ISHIHAMA Akira
• Screaning of E.coli Genes That Participate in the Partitioning of F Plasmid DNA

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1993 -1994 

  Author : MIKI Takeyoshi; SEKIMIZU Kazuhisa
• A study of the topological change of DNA in Escherichia coli induced by heat shock.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1992 -1993 

  Author : SEKIMIZU Kazuhisa
• Studies on the conformation and functions of ras-related low Mr GTP-binding proteins.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1991 -1992 

  Author : NOZAWA Yoshinori; MATSUMOTO Kunihiro; YAMAMOTO Masayuki; NARUMIYA Shuh; KATADA Toshiaki; TAKAI Yoshimi
• 大学における研究設備の整備充実に関する調査研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1991 -1991 

  Author : 久城 育夫; 小宮山 進; 関水 和久; 塩田 邦郎; 脊山 洋右; 岸尾 光二
• X線構造解析のためのDNA複製開始系蛋白質dnaAの結晶化

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1990 -1990 

  Author : 佐藤 能雅; 関水 和久
• 細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1990 -1990 

  Author : 花岡 文雄; 田矢 洋一; 野瀬 清; 関水 和久; 井出 利憲; 西島 正弘
• 細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1989 -1989 

  Author : 花岡 文雄; 田矢 洋一; 野瀬 清; 関水 和久; 井出 利憲; 西島 正弘
• 細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1988 -1988 

  Author : 花岡 文雄; 井出 利憲; 関水 和久; 野瀬 清; 田矢 洋一; 西島 正弘