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Sekimizu Kazuhisa
Faculty of Pharma-Science Specially Appointed Professor
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Last Updated :2024/03/28
Researcher Information
Affiliation
Faculty of Pharma-Science Specially Appointed Professor
URL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202301016710211380
Research funding number
90126095
J-Global ID
202301016710211380
Research Interests
Drug discoveries with silkworms
Research Activity Information
Published Papers
Molecular Editing Enhances Oxidation Resistance of Mena‐quinone‐Targeting Antibiotics Lysocin E and WAP‐8294A2
Junhao Fu; Yosuke Nakata; Hiroaki Itoh; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue
Chemistry – A European Journal Wiley 0947-6539 2023/06
Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives.
Yosuke Nakata; Junhao Fu; Hiroaki Itoh; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue
Chemistry (Weinheim an der Bergstrasse, Germany) e202301225 2023/05
High molecular weight glucose homopolymer of broccoli (Brassica oleracea var. italica) stimulates both invertebrate and mammalian immune systems
Atsushi Miyashita; Keiko Kataoka; Toshio Tsuchida; Akihiko Ano Ogasawara; Hiroto Nakajima; Megumu Takahashi; Kazuhisa Sekimizu
Frontiers in Food Science and Technology Frontiers Media SA 3 2023/02
選抜ワークショップ5:抗菌性物質、薬剤耐性 新規抗生物質ライソシンEは宿主と微生物の相互作用を利用して高い治療効果を発揮する
浜本 洋; Panthee Suresh; Paudel Atmika; 宮下 惇嗣; 関水 和久
日本細菌学雑誌 日本細菌学会 77 (1) 57 - 57 0021-4930 2022/02
Repurposing the PDMA-approved drugs in Japan using an insect model of staphylococcal infection.
Atsushi Miyashita; Shuhei Mitsutomi; Tohru Mizushima; Kazuhisa Sekimizu
FEMS microbes 3 xtac014 2022
Contribution of rsaC, a small non-coding RNA, towards the pathogenicity of Staphylococcus aureus in a mouse systemic infection model
Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Suguru Ohgi; Kazuhisa Sekimizu
bioRxiv Cold Spring Harbor Laboratory 2021/10
in vivo RNA-Seq解析に基づくCryptococcus neoformansの病原性因子の網羅的探索
浜本 洋; 石島 早苗; スレス・パンシー; アトミカ・パウデル; 関水 和久
日本医真菌学会雑誌 (一社)日本医真菌学会 62 (Suppl.1) 100 - 100 2434-5229 2021/10
Transcriptome change in Staphylococcus aureus in infecting mice
Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Ohgi Suguru; Yutaka Suzuki; Kazuhisa Sekimizu
preprint on ResearchSquare Research Square Platform LLC 2021/07
Purification of immunostimulatory glucose homopolymer from broccoli (Brassica oleracea var. italica)
Atsushi Miyashita; Keiko Kataoka; Toshio Tsuchida; Akihiko Ano Ogasawara; Hiroshi Hamamoto; Megumu Takahashi; Kazuhisa Sekimizu
bioRxiv Cold Spring Harbor Laboratory 2021/05
Activation of innate immunity by neutral polysaccharides from broccoli buds
Atsushi Miyashita; Keiko Kataoka; Kazuhisa Sekimizu
bioRxiv Cold Spring Harbor Laboratory 2021/03
Serum proteins potentiate therapeutic efficacy of lysocin E against S. aureus
Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Kenichi Ishii; Jyunichiro Yasukawa; Su Jie; Hiroaki Itoh; Kotaro Tokumoto; Masayuki Inoue; Kazuhisa Sekimizu
preprint at researchsquare Research Square 2020/11
白癬菌汚染した靴を揮発性の抗菌アロマ成分を用いて除菌する実用法の開発 インソール;靴中敷
石島 早苗; 比留間 政太郎; 大島 浩智; 鈴木 修; 村井 隆; 笠井 庄治; 江澤 邦夫; 関水 和久; 安部 茂
日本医真菌学会雑誌 (一社)日本医真菌学会 61 (Suppl.) 89 - 89 2434-5229 2020/09
Cryptococcus neoformansの病原性因子の網羅的探索
浜本 洋; 石島 早苗; スレス・パンシー; アトミカ・パウデル; 関水 和久
日本医真菌学会雑誌 (一社)日本医真菌学会 61 (Suppl.) 82 - 82 2434-5229 2020/09
酵母加熱死菌によるカイコの自然免疫の過度な活性化と殺傷
石島 早苗; 宮下 惇嗣; 浜本 洋; 関水 和久
日本医真菌学会雑誌 (一社)日本医真菌学会 61 (Suppl.) 86 - 86 2434-5229 2020/09
Candida albicans TIMM1768株の全ゲノム配列の解析
浜本 洋; Panthee Suresh; Paudel Atmika; 石島 早苗; 関水 和久
Medical Mycology Research 帝京大学医真菌研究センター 9 (1) 37 - 40 1883-3195 2018/12
ナノポアシークエンサーを用いたCandida albicans TIMM1768株の全ゲノム解析
浜本 洋; スレス・パンシー; 石島 早苗; 関水 和久
Medical Mycology Journal (一社)日本医真菌学会 59 (Suppl.1) 87 - 87 2185-6486 2018/08
Candida albicans TIMM1768株の酵母形、菌糸形での発現遺伝子解析
石島 早苗; 浜本 洋; 山田 剛; 安部 茂; 関水 和久
Medical Mycology Journal (一社)日本医真菌学会 59 (Suppl.1) 87 - 87 2185-6486 2018/08
ショ糖の摂食による血糖値の上昇を抑制する物質の探索のためのカイコの応用
松本 靖彦; 石井 雅樹; 関水 和久
Medical Mycology Research 帝京大学医真菌研究センター 8 (1) 33 - 38 1883-3195 2017/12
[Refereed]
Silkworm infection models of filamentous fungi for developing antifungal agents
石井 雅樹; 松本 靖彦; 山田 剛; 安部 茂; 関水 和久
Medical mycology research 帝京大学医真菌研究センター 8 (1) 39 - 43 1883-3195 2017
[Refereed]
病原性真菌Cryptococcus neoformansの感染機構の解明のためカイコの利用
松本 靖彦; 石井 雅樹; 関水 和久
Medical Mycology Research 帝京大学医真菌研究センター 7 (1) 21 - 25 1883-3195 2016/12
[Refereed]
新規抗生物質カイコシンEの治療効果の基礎となる分子メカニズム
安川 淳一朗; 浜本 洋; ジー・スー; パウデル・アトミカ; 浦井 誠; 西田 智; 関水 和久
日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 87回 [4T13a - 09] 2014/10
[Refereed]
Impact of psm-mec in the mobile genetic element on the clinical characteristics and outcome of SCCmec-II methicillin-resistant Staphylococcus aureus bacteraemia in Japan
Aoyagi T; Kaito C; Sekimizu K; Omae Y; Saito Y; Mao H; Inomata S; Hatta M; Endo S; Kanamori H; Gu Y; Tokuda K; Yano H; Kitagawa M; Kaku M
Clin Microbiol Infect. WILEY-BLACKWELL 20 (9) 912 - 919 1198-743X 2014/09
[Refereed]
Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents (vol 66, pg 663, 2013)
Atmika Paudel; Keiichi Kaneko; Ayako Watanabe; Shigeki Matsunaga; Motomu Kanai; Hiroshi Hamamoto; Kazuhisa Sekimizu
JOURNAL OF ANTIBIOTICS JAPAN ANTIBIOTICS RESEARCH ASSOC 67 (2) 203 - 203 0021-8820 2014/02
[Refereed]
Evaluation of Innate Immune Stimulating Activity of Polysaccharides Using a Silkworm (Bombyx Mori) Muscle Contraction Assay
Tomoko Fujiyuki; Tadahiro Takeda; Hiroshi Hamamoto; Kenichi Ishii; Makoto Urai; Keiko Kataoka; Shoji Shibata; Kazuhisa Sekimizu
drug discoveries & therapeutics 2 6 (2) 88 - 93 1881-784x 2013
[Refereed]
Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay.
Saphala Dhital; Hiroshi Hamamoto; Makoto Urai; Kenichi Ishii; Kazuhisa Sekimizu
Drug Discoveries & Therapeutics 1 5 (1) 18 - 25 1881-7831 2011/02
[Refereed]
Isolation of mammalian pathogenic bacteria using silkworms
Kaito C; Usui K; Kyuma T; Sekimizu K
Drug Discoveries and Therapeutics 5 (2) 66 - 70 2011
[Refereed]
Hemocytes and humoral factors in silkworm blood are cooperatively involved in sheep erythrocyte aggregation
Katsutoshi Imamura; Kenichi Ishii; Hiroshi Hamamoto; Kazuhisa Sekimizu
Drug Discoveries & Therapeutics 3 5 (3) 125 - 129 1881-784X 2011
[Refereed]
Evaluation of therapeutic effects and pharmacokinetics of antibacterial chromogenic agents in a silkworm model of Staphylococcus aureus infection.
Fujiyuki T; Imamura K; Hamamoto H; Sekimizu K
Drug Discoveries & Therapeutics 5 4 (5) 349 - 354 1881-7831 2010/10
[Refereed]
薬剤耐性菌アップデイト 宿主免疫回避におけるサルモネラ薬剤排出ポンプの生理的役割
西野 邦彦; 坂田 博樹; 二階堂 英司; 城阪 郁江; 西野 美都子; 松本 佳巳; 松本 靖彦; 垣内 力; 関水 和久; 山口 明人; 上田 珠美; 田中 真奈美; 中濃 知志
日本細菌学雑誌 日本細菌学会 64 (1) 91 - 91 0021-4930 2009/02
[Refereed]
Pharmacologic action of oseltamivir on the nervous system.
Kenichi Ishii; Hiroshi Hamamoto; Takuya Sasaki; Yuji Ikegaya; Kenzo Yamatsugu; Motomu Kanai; Masakatsu Shibasaki; Kazuhisa Sekimizu
Drug Discoveries & Therapeutics 1 2 (1) 24 - 34 1881-7831 2008/02
[Refereed]
A novel method to suppress the dispersal of Japanese cedar pollen by inducing morphologic changes with weak alkaline solutions.
Kenichi Ishii; Hiroshi Hamamoto; Kazuhisa Sekimizu
Drug Discoveries & Therapeutics 2 1 (2) 124 - 129 1881-7831 2007/10
[Refereed]
Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain
H Takeuchi; E Kage; M Sawata; A Kamikouchi; K Ohashi; M Ohara; T Fujiyuki; T Kunieda; K Sekimizu; S Natori; T Kubo
INSECT MOLECULAR BIOLOGY BLACKWELL SCIENCE LTD 10 (5) 487 - 494 0962-1075 2001/10
[Refereed]
Conference Activities & Talks
Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret.
Hiroshi Hamamoto; Atsushi Miyashita; Koushirou Kamura; Ryo Horie; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2022/12
Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus).
Atsushi Miyashita; Kazuhisa Sekimizu; Chikara Kaito
Drug discoveries & therapeutics 2022/11
Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220.
Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Chikara Kaito; Yutaka Suzuki; Kazuhisa Sekimizu
Heliyon 2022/11
Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.
Geberemichal Geberetsadik; Akane Inaizumi; Akihito Nishiyama; Takehiro Yamaguchi; Hiroshi Hamamoto; Suresh Panthee; Aki Tamaru; Manabu Hayatsu; Yusuke Mizutani; Shaban Amina Kaboso; Mariko Hakamata; Aleksandr Ilinov; Yuriko Ozeki; Yoshitaka Tateishi; Kazuhisa Sekimizu; Sohkichi Matsumoto
Antimicrobial agents and chemotherapy 2022/09
Transcriptome change of Staphylococcus aureus in infected mouse liver.
Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Suguru Ohgi; Yutaka Suzuki; Koichi Makimura; Kazuhisa Sekimizu
Communications biology 2022/07
Peanut triacylglycerols activate innate immunity both in insects and mammals.
Wenyuan Li; Atsushi Miyashita; Kazuhisa Sekimizu
Scientific reports 2022/05
Establishment of a polymerase chain reaction-based method for strain-level management of Enterococcus faecalis EF-2001 using species-specific sequences identified by whole genome sequences.
Hiroshi Hamamoto; Akihiko Ano Ogasawara; Masahiro Iwasa; Kazuhisa Sekimizu
Frontiers in microbiology 2022
An efficient method to screen for the soil bacteria producing therapeutically effective antibiotics.
Hiroshi Hamamoto; Suresh Panthee; Kana Hashimoto; Toshio Tsuchida; Kazuhisa Sekimizu
The Journal of antibiotics 2021/12
YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus.
Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Tom Grunert; Kazuhisa Sekimizu
Virulence 2021/12
Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model.
Suresh Panthee; Hiroshi Hamamoto; Yayoi Nishiyama; Atmika Paudel; Kazuhisa Sekimizu
Journal of fungi (Basel, Switzerland) 2021/11
Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus.
Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Kenichi Ishii; Jyunichiro Yasukawa; Jie Su; Atsushi Miyashita; Hiroaki Itoh; Kotaro Tokumoto; Masayuki Inoue; Kazuhisa Sekimizu
Nature communications 2021/11
A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies.
Hiroto Nakajima; Atsushi Miyashita; Hiroshi Hamamoto; Kazuhisa Sekimizu
Scientific reports 2021/05
Evaluation of pathogenicity and therapeutic effectiveness of antibiotics using silkworm Nocardia infection model.
Kazuhiro Mikami; Kazunari Sonobe; Keiko Ishino; Takumi Noda; Mami Kato; Mami Hanao; Hiroshi Hamamoto; Kazuhisa Sekimizu; Mitsuhiro Okazaki
Drug discoveries & therapeutics 2021/05
Using silkworms to search for lactic acid bacteria that contribute to infection prevention and improvement of hyperglycemia.
Atsushi Miyashita; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2021/05
Complete genome sequence and comparative genomic analysis of Enterococcus faecalis EF-2001, a probiotic bacterium.
Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Akihiko Ano Ogasawara; Toshihiro Iwasa; Jochen Blom; Kazuhisa Sekimizu
Genomics 2021/05
A digital scheme of human trials for the evaluation of functional foods.
Atsushi Miyashita; Kazuyuki Shimomura; Hiroto Nakajima; Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2021/03
Applying the silkworm model for the search of immunosuppressants.
Atsushi Miyashita; Hiroshi Hamamoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2021
Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library.
Yuri Takada; Hiroaki Itoh; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue
Nature communications 2020/10
A simple artificial diet available for research of silkworm disease models.
Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2020/09
Large-Scale Screening and Identification of Novel Pathogenic Staphylococcus aureus Genes Using a Silkworm Infection Model.
Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Yasuhiko Matsumoto; Kazuhisa Sekimizu
The Journal of infectious diseases 2020/05
Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter.
Chikara Kaito; Hirono Yoshikai; Ai Wakamatsu; Atsushi Miyashita; Yasuhiko Matsumoto; Tomoko Fujiyuki; Masaru Kato; Yoshitoshi Ogura; Tetsuya Hayashi; Takao Isogai; Kazuhisa Sekimizu
PLoS pathogens 2020/04
The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus.
Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Anne-Catrin Uhlemann; Kazuhisa Sekimizu
Frontiers in microbiology 2020
Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells.
Yasuhiko Matsumoto; Miki Takahashi; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2020
GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus.
Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu
RSC advances 2019/11
Suppressive effects of whey protein hydrolysate on sucrose-induced hyperglycemia in silkworms.
Yasuhiko Matsumoto; Miki Takahashi; Masahiro Umehara; Masato Asano; Hiroko Maruki-Uchida; Minoru Morita; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2019/11
Identification of 2H phosphoesterase superfamily proteins with 2'-CPDase activity.
Shuhei Mitsutomi; Nobuyoshi Akimitsu; Kazuhisa Sekimizu; Chikara Kaito
Biochimie 2019/10
Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment.
Daniel Don Nwibo; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2019/07
Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E.
Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue
Nature communications 2019/07
Pharmacokinetics of anti-infectious reagents in silkworms.
Hiroshi Hamamoto; Ryo Horie; Kazuhisa Sekimizu
Scientific reports 2019/07
Silkworm as an experimental animal for research on fungal infections.
Yasuhiko Matsumoto; Kazuhisa Sekimizu
Microbiology and immunology 2019/02
Detection of Trichophyton spp. from footwear of patients with tinea pedis.
Sanae A Ishijima; Masataro Hiruma; Kazuhisa Sekimizu; Shigeru Abe
Drug discoveries & therapeutics 2019
Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis.
Suresh Panthee; Atmika Paudel; Jochen Blom; Hiroshi Hamamoto; Kazuhisa Sekimizu
Frontiers in microbiology 2019
Additive effects of Kothala himbutu (Salacia reticulata) extract and a lactic acid bacterium (Enterococcus faecalis YM0831) for suppression of sucrose-induced hyperglycemia in an in vivo silkworm evaluation system.
Masaki Ishii; Yasuhiko Matsumoto; Toshiaki Katada; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2019
Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph.
Hiroki Ryuno; Fuki Nigo; Isao Naguro; Kazuhisa Sekimizu; Chikara Kaito
PloS one 2019
Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans.
Yasuhiko Matsumoto; Masaki Ishii; Setsuo Hasegawa; Kazuhisa Sekimizu
Communications biology 2019
Bacterial polysaccharides inhibit sucrose-induced hyperglycemia in silkworms.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2018/09
Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 1768.
Suresh Panthee; Hiroshi Hamamoto; Sanae A Ishijima; Atmika Paudel; Kazuhisa Sekimizu
Genome biology and evolution 2018/08
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.
Tomohiro Maruyama; Takashi Baba; Yuki Maemoto; Chikako Hara-Miyauchi; Minami Hasegawa-Ogawa; Hirotaka James Okano; Yuki Enda; Kei Matsumoto; Nagisa Arimitsu; Kazuki Nakao; Hiroshi Hamamoto; Kazuhisa Sekimizu; Takayo Ohto-Nakanishi; Hiroki Nakanishi; Takeshi Tokuyama; Shigeru Yanagi; Mitsuo Tagaya; Katsuko Tani
Cell death & disease 2018/07
Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic.
Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue
The Journal of organic chemistry 2018/07
Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model.
Atmika Paudel; Suresh Panthee; Makoto Urai; Hiroshi Hamamoto; Tomohiko Ohwada; Kazuhisa Sekimizu
Scientific reports 2018/01
Establishment of a gnotobiotic silkworm model.
Hiroto Nakajima; Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2018
Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation system.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2018
[Development of Antibiotics Using Silkworm Bacteria and Fungi Infection Model].
Hiroshi Hamamoto; Kazuhisa Sekimizu
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2018
[Platform Development for Drug Discovery Utilizing Silkworm towards "Novel Industrial Revolution"].
Kazuhisa Sekimizu; Kohji Itoh
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2018
Estimation of lactic acid bacterial cell number by DNA quantification.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2018
In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms.
Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi
Pharmaceutical biology 2017/12
Evaluation of the innate immune-stimulating activity of amazake using a silkworm muscle contraction assay.
Hiroko Maruki-Uchida; Masahiko Sai; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2017/11
Isolation of antibiotic-producing Pseudomonas species with low-temperature cultivation of temperate soil.
Shuhei Mitsutomi; Kazuhisa Sekimizu; Chikara Kaito
Drug discoveries & therapeutics 2017/11
Two-spotted cricket as an animal infection model of human pathogenic fungi.
Yuto Kochi; Yasuhiko Matsumoto; Kazuhisa Sekimizu; Chikara Kaito
Drug discoveries & therapeutics 2017/11
Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from Rhizobium sp. strain M2 screened using a silkworm muscle contraction assay.
Makoto Urai; Tomoko Aizawa; Katsutoshi Imamura; Hiroshi Hamamoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2017/11
Structural analysis of an innate immunostimulant from broccoli, Brassica oleracea var. italica.
Makoto Urai; Keiko Kataoka; Satoshi Nishida; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2017/11
An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis.
Masaki Ishii; Yasuhiko Matsumoto; Tsuyoshi Yamada; Shigeru Abe; Kazuhisa Sekimizu
Scientific reports 2017/09
Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions.
Haruka Fujino; Masanori Nagatomo; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue
Angewandte Chemie (International ed. in English) 2017/09
D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus.
Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu
The Journal of antibiotics 2017/07
Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b.
Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu
Genome announcements 2017/06
Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus.
Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu
The Journal of antibiotics 2017/06
Genomic analysis of vancomycin-resistant Staphylococcus aureus VRS3b and its comparison with other VRSA isolates.
Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2017/05
Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract.
Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi
Drug discoveries & therapeutics 2017/05
Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori).
Kantaporn Kheawfu; Surachai Pikulkaew; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi
Drug discoveries & therapeutics 2017/05
Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis.
Akiho Yagi; Ryuji Uchida; Hiroshi Hamamoto; Kazuhisa Sekimizu; Ken-Ichi Kimura; Hiroshi Tomoda
The Journal of antibiotics 2017/05
Silkworm fungal infection model for identification of virulence genes in pathogenic fungus and screening of novel antifungal drugs.
Masaki Ishii; Yasuhiko Matsumoto; Ikuko Nakamura; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2017/03
Decreased sugar concentration in vegetable and fruit juices by growth of functional lactic acid bacteria.
Masaki Ishii; Yasuhiko Matsumoto; Satoshi Nishida; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2017/03
Lactic acid bacteria of the Leuconostoc genus with high innate immunity-stimulating activity.
Masaki Ishii; Satoshi Nishida; Keiko Kataoka; Yayoi Nishiyama; Shigeru Abe; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2017/03
In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-5.
Suresh Panthee; Hiroshi Hamamoto; Yutaka Suzuki; Kazuhisa Sekimizu
The Journal of antibiotics 2017/02
[A Silkworm Infection Model to Evaluate Antifungal Drugs for Cryptococcosis].
Yasuhiko Matsumoto; Masaki Ishii; Kiminori Shimizu; Susumu Kawamoto; Kazuhisa Sekimizu
Medical mycology journal 2017
A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus.
Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Keiichi Kaneko; Shigeki Matsunaga; Motomu Kanai; Yutaka Suzuki; Kazuhisa Sekimizu
Frontiers in microbiology 2017
[The Usefulness of Silkworms as a Model Animal for Evaluating the Effectiveness of Medicine and Food].
Kazuhisa Sekimizu
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2017
[Development of Novel Antibiotic Lysocin E Identified by Silkworm Infection Model].
Hiroshi Hamamoto; Kazuhisa Sekimizu
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2017
Lactobacillus paraplantarum 11-1 Isolated from Rice Bran Pickles Activated Innate Immunity and Improved Survival in a Silkworm Bacterial Infection Model.
Satoshi Nishida; Masaki Ishii; Yayoi Nishiyama; Shigeru Abe; Yasuo Ono; Kazuhisa Sekimizu
Frontiers in microbiology 2017
Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents.
Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu
Frontiers in microbiology 2017
Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection.
Ikuko Nakamura; Ryuichi Kanasaki; Koji Yoshikawa; Shigetada Furukawa; Akihiko Fujie; Hiroshi Hamamoto; Kazuhisa Sekimizu
The Journal of antibiotics 2017/01
Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity.
Takuya Kaji; Motoki Murai; Hiroaki Itoh; Jyunichiro Yasukawa; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue
Chemistry (Weinheim an der Bergstrasse, Germany) 2016/11
A silkworm infection model to investigate Vibrio vulnificus virulence genes.
Mai Yamamoto; Takashige Kashimoto; Yukihiro Yoshimura; Nao Tachibana; Shiho Kuroda; Yoshiko Miki; Sou Kitabayashi; Ping Tong; Jianbo Xiao; Koichi Tanaka; Hiroshi Hamamoto; Kazuhisa Sekimizu; Koichiro Yamamoto
Molecular medicine reports 2016/11
Lysobacter species: a potential source of novel antibiotics.
Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Kazuhisa Sekimizu
Archives of microbiology 2016/11
Novel Nucleoside Diphosphatase Contributes to Staphylococcus aureus Virulence.
Kenta Imae; Yuki Saito; Hayato Kizaki; Hiroki Ryuno; Han Mao; Atsushi Miyashita; Yutaka Suzuki; Kazuhisa Sekimizu; Chikara Kaito
The Journal of biological chemistry 2016/09
A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus.
Yuto Kochi; Atsushi Miyashita; Kohsuke Tsuchiya; Masao Mitsuyama; Kazuhisa Sekimizu; Chikara Kaito
FEMS microbiology letters 2016/08
Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus.
Atsushi Miyashita; Hayato Kizaki; Kazuhisa Sekimizu; Chikara Kaito
Biology open 2016/06
An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia.
Yasuhiko Matsumoto; Masaki Ishii; Kazuhisa Sekimizu
Scientific reports 2016/05
A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus.
Yasuhiko Matsumoto; Jyunichiro Yasukawa; Masaki Ishii; Yohei Hayashi; Shinya Miyazaki; Kazuhisa Sekimizu
Scientific reports 2016/03
Acute oral toxicity test of chemical compounds in silkworms.
Kimihito Usui; Satoshi Nishida; Takuya Sugita; Takuro Ueki; Yasuhiko Matsumoto; Hidenobu Okumura; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016/02
Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm.
Satoshi Nishida; Yasuo Ono; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016/02
Using silkworms to establish alternative animal models for evaluation of drug-induced tissue injury.
Yoshinori Inagaki; Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016/02
Using silkworms as a laboratory animal to evaluate medicines and foods.
Kazuhisa Sekimizu; Hiroshi Hamamoto
Drug discoveries & therapeutics 2016/02
Evaluation of anti-diabetic drugs by using silkworm, Bombyx mori.
Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016/02
Identification of lysocin E using a silkworm model of bacterial infection.
Hiroshi Hamamoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016/02
A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine.
Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016/02
Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016/02
Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins.
Hirono Yoshikai; Hayato Kizaki; Yuki Saito; Yosuke Omae; Kazuhisa Sekimizu; Chikara Kaito
The Journal of infectious diseases 2016/01
An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces.
Masakazu Nakadai; Shuta Tomida; Kazuhisa Sekimizu
Scientific reports 2016/01
Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading.
Hayato Kizaki; Yosuke Omae; Fumiaki Tabuchi; Yuki Saito; Kazuhisa Sekimizu; Chikara Kaito
PloS one 2016
Dividing phase-dependent cytotoxicity profiling of human embryonic lung fibroblast identifies candidate anticancer reagents.
Yoshinori Inagaki; Yasuhiko Matsumoto; Wei Tang; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016
Menaquinone as a potential target of antibacterial agents.
Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2016
No Effect of Body Size on the Frequency of Calling and Courtship Song in the Two-Spotted Cricket, Gryllus bimaculatus.
Atsushi Miyashita; Hayato Kizaki; Kazuhisa Sekimizu; Chikara Kaito
PloS one 2016
16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus.
Tatsuhiko Kyuma; Hayato Kizaki; Hiroki Ryuno; Kazuhisa Sekimizu; Chikara Kaito
Biochimie 2015/12
Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.
Kenichi Ishii; Fumiaki Tabuchi; Miki Matsuo; Keita Tatsuno; Tomoaki Sato; Mitsuhiro Okazaki; Hiroshi Hamamoto; Yasuhiko Matsumoto; Chikara Kaito; Tetsuji Aoyagi; Keiichi Hiramatsu; Mitsuo Kaku; Kyoji Moriya; Kazuhisa Sekimizu
Scientific reports 2015/11
A novel mutation in the vraS gene of Staphylococcus aureus contributes to reduce susceptibility against daptomycin.
Jie Su; Maki Iehara; Jyunichiro Yasukawa; Yasuhiko Matsumoto; Hiroshi Hamamoto; Kazuhisa Sekimizu
The Journal of antibiotics 2015/10
Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2015/08
Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies.
Kenichi Ishii; Hiroshi Hamamoto; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2015/08
Niemann-Pick disease type C2 protein induces autophagy and inhibits growth in FM3A breast cancer cells.
Tatsuo Adachi; Yasuhiko Matsumoto; Yoshinori Inagaki; Kazuhisa Sekimizu
Drug discoveries & therapeutics 2015/08
Ribosomal RNA methyltransferases contribute to Staphylococcus aureus virulence.
Tatsuhiko Kyuma; Satoshi Kimura; Yuichi Hanada; Tsutomu Suzuki; Kazuhisa Sekimizu; Chikara Kaito
The FEBS journal 2015/07
MISC
Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret.
Hiroshi Hamamoto; Atsushi Miyashita; Koushirou Kamura; Ryo Horie; Kazuhisa Sekimizu Drug discoveries & therapeutics 16- (6) 280 -285 2022/12
Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus).
Atsushi Miyashita; Kazuhisa Sekimizu; Chikara Kaito Drug discoveries & therapeutics 16- (5) 204 -209 2022/11
Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220.
Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Chikara Kaito; Yutaka Suzuki; Kazuhisa Sekimizu Heliyon 8- (11) e11376 2022/11
Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.
Geberemichal Geberetsadik; Akane Inaizumi; Akihito Nishiyama; Takehiro Yamaguchi; Hiroshi Hamamoto; Suresh Panthee; Aki Tamaru; Manabu Hayatsu; Yusuke Mizutani; Shaban Amina Kaboso; Mariko Hakamata; Aleksandr Ilinov; Yuriko Ozeki; Yoshitaka Tateishi; Kazuhisa Sekimizu; Sohkichi Matsumoto Antimicrobial agents and chemotherapy 66- (9) e0017122 2022/09
Transcriptome change of Staphylococcus aureus in infected mouse liver.
Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Suguru Ohgi; Yutaka Suzuki; Koichi Makimura; Kazuhisa Sekimizu Communications biology 5- (1) 721 -721 2022/07
Peanut triacylglycerols activate innate immunity both in insects and mammals.
Wenyuan Li; Atsushi Miyashita; Kazuhisa Sekimizu Scientific reports 12- (1) 7464 -7464 2022/05
カイコ創薬最前線:ヒトバイオ医薬品生産・ヒト疾患モデル開発への展開 カイコを用いた過剰炎症モデルの作出と創薬研究への展望
宮下 惇嗣; 関水 和久 日本薬学会年会要旨集 142年会- S12 -5 2022/03
Cryptococcus neoformansの病原性因子の網羅的探索
浜本洋; 石島早苗; PANTHEE Suresh; 関水和久 関東医真菌懇話会プログラム・抄録集 41st- 2022
Cryptococcus neoformansの病原性発揮機構の網羅的な理解
浜本洋; 石島早苗; 関水和久 日本医真菌学会雑誌 63- (Supplement 1) 2022
Establishment of a polymerase chain reaction-based method for strain-level management of Enterococcus faecalis EF-2001 using species-specific sequences identified by whole genome sequences.
Hiroshi Hamamoto; Akihiko Ano Ogasawara; Masahiro Iwasa; Kazuhisa Sekimizu Frontiers in microbiology 13- 959063 -959063 2022
YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus.
Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Tom Grunert; Kazuhisa Sekimizu Virulence 12- (1) 470 -480 2021/12
An efficient method to screen for the soil bacteria producing therapeutically effective antibiotics.
Hiroshi Hamamoto; Suresh Panthee; Kana Hashimoto; Toshio Tsuchida; Kazuhisa Sekimizu The Journal of antibiotics 74- (12) 850 -855 2021/12
Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model.
Suresh Panthee; Hiroshi Hamamoto; Yayoi Nishiyama; Atmika Paudel; Kazuhisa Sekimizu Journal of fungi (Basel, Switzerland) 7- (11) 2021/11
Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus.
Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Kenichi Ishii; Jyunichiro Yasukawa; Jie Su; Atsushi Miyashita; Hiroaki Itoh; Kotaro Tokumoto; Masayuki Inoue; Kazuhisa Sekimizu Nature communications 12- (1) 6364 -6364 2021/11
A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies.
Hiroto Nakajima; Atsushi Miyashita; Hiroshi Hamamoto; Kazuhisa Sekimizu Scientific reports 11- (1) 10757 -10757 2021/05
Using silkworms to search for lactic acid bacteria that contribute to infection prevention and improvement of hyperglycemia.
Atsushi Miyashita; Kazuhisa Sekimizu Drug discoveries & therapeutics 15- (2) 51 -54 2021/05
Evaluation of pathogenicity and therapeutic effectiveness of antibiotics using silkworm Nocardia infection model.
Kazuhiro Mikami; Kazunari Sonobe; Keiko Ishino; Takumi Noda; Mami Kato; Mami Hanao; Hiroshi Hamamoto; Kazuhisa Sekimizu; Mitsuhiro Okazaki Drug discoveries & therapeutics 15- (2) 73 -77 2021/05
Complete genome sequence and comparative genomic analysis of Enterococcus faecalis EF-2001, a probiotic bacterium.
Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Akihiko Ano Ogasawara; Toshihiro Iwasa; Jochen Blom; Kazuhisa Sekimizu Genomics 113- (3) 1534 -1542 2021/05
A digital scheme of human trials for the evaluation of functional foods.
Atsushi Miyashita; Kazuyuki Shimomura; Hiroto Nakajima; Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 15- (1) 9 -13 2021/03
転写伸長因子S-IIを標的とした真菌感染症治療薬
宮下惇嗣; 松本靖彦; 山田剛; 清水公徳; 成瀬啓樹; 本間誠之; 巻秀樹; 川本進; 関水和久 日本医真菌学会雑誌 62- (Supplement 1) 106 -106 2021
生物間相互作用に基づくカイコ創薬
宮下惇嗣; 関水和久; 関水和久 日本生化学会大会(Web) 94th- [2S06e -03] 2021
Applying the silkworm model for the search of immunosuppressants.
Atsushi Miyashita; Hiroshi Hamamoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 15- (3) 139 -142 2021
Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library.
Yuri Takada; Hiroaki Itoh; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue Nature communications 11- (1) 4935 -4935 2020/10
A simple artificial diet available for research of silkworm disease models.
Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 14- (4) 177 -180 2020/09
カンジダの発育抑制活性を示すココナッツ油およびリパーゼ含有歯磨き剤開発の試み
羽山 和美; 二宮 健太郎; 関水 和久; 安部 茂 日本医真菌学会雑誌 61- (Suppl.) 81 -81 2020/09
Large-Scale Screening and Identification of Novel Pathogenic Staphylococcus aureus Genes Using a Silkworm Infection Model.
Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Yasuhiko Matsumoto; Kazuhisa Sekimizu The Journal of infectious diseases 221- (11) 1795 -1804 2020/05
Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter.
Chikara Kaito; Hirono Yoshikai; Ai Wakamatsu; Atsushi Miyashita; Yasuhiko Matsumoto; Tomoko Fujiyuki; Masaru Kato; Yoshitoshi Ogura; Tetsuya Hayashi; Takao Isogai; Kazuhisa Sekimizu PLoS pathogens 16- (4) e1008469 2020/04
Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells.
Yasuhiko Matsumoto; Miki Takahashi; Kazuhisa Sekimizu Drug discoveries & therapeutics 14- (1) 8 -13 2020
The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus.
Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Anne-Catrin Uhlemann; Kazuhisa Sekimizu Frontiers in microbiology 11- 2076 -2076 2020
GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus.
Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu RSC advances 9- (65) 37889 -37894 2019/11
Suppressive effects of whey protein hydrolysate on sucrose-induced hyperglycemia in silkworms.
Yasuhiko Matsumoto; Miki Takahashi; Masahiro Umehara; Masato Asano; Hiroko Maruki-Uchida; Minoru Morita; Kazuhisa Sekimizu Drug discoveries & therapeutics 13- (5) 244 -247 2019/11
Candida albicans発育に及ぼす乳酸菌死菌体と発酵β-グルカン誘導腹腔内細胞の組み合わせの効果
羽山 和美; 鈴木 基文; 久下 高生; 岩佐 広行; 安部 茂; 関水 和久 日本医真菌学会雑誌 60- (Suppl.1) 101 -101 2019/10
白癬菌汚染した靴を揮発性の抗菌アロマ成分を用いて除菌する実用法の開発(インソール;靴中敷)
石島 早苗; 比留間 政太郎; 大島 浩智; 鈴木 修; 江澤 邦夫; 関水 和久; 安部 茂 日本医真菌学会雑誌 60- (Suppl.1) 86 -86 2019/10
Cryptococcus neoformansのマウス感染状態における網羅的遺伝子発現解析
浜本 洋; スレス・パンシー; アトミカ・パウデル; 石島 早苗; 関水 和久 日本医真菌学会雑誌 60- (Suppl.1) 87 -87 2019/10
Identification of 2H phosphoesterase superfamily proteins with 2'-CPDase activity.
Shuhei Mitsutomi; Nobuyoshi Akimitsu; Kazuhisa Sekimizu; Chikara Kaito Biochimie 165- 235 -244 2019/10
Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment.
Daniel Don Nwibo; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 13- (3) 145 -149 2019/07
Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E.
Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue Nature communications 10- (1) 2992 -2992 2019/07
Pharmacokinetics of anti-infectious reagents in silkworms.
Hiroshi Hamamoto; Ryo Horie; Kazuhisa Sekimizu Scientific reports 9- (1) 9451 -9451 2019/07
Silkworm as an experimental animal for research on fungal infections.
Yasuhiko Matsumoto; Kazuhisa Sekimizu Microbiology and immunology 63- (2) 41 -50 2019/02
Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans.
Yasuhiko Matsumoto; Masaki Ishii; Setsuo Hasegawa; Kazuhisa Sekimizu Communications biology 2- 157 -157 2019
Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph.
Hiroki Ryuno; Fuki Nigo; Isao Naguro; Kazuhisa Sekimizu; Chikara Kaito PloS one 14- (5) e0217517 2019
Additive effects of Kothala himbutu (Salacia reticulata) extract and a lactic acid bacterium (Enterococcus faecalis YM0831) for suppression of sucrose-induced hyperglycemia in an in vivo silkworm evaluation system.
Masaki Ishii; Yasuhiko Matsumoto; Toshiaki Katada; Kazuhisa Sekimizu Drug discoveries & therapeutics 13- (3) 133 -136 2019
Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis.
Suresh Panthee; Atmika Paudel; Jochen Blom; Hiroshi Hamamoto; Kazuhisa Sekimizu Frontiers in microbiology 10- 1619 -1619 2019
Detection of Trichophyton spp. from footwear of patients with tinea pedis.
Sanae A Ishijima; Masataro Hiruma; Kazuhisa Sekimizu; Shigeru Abe Drug discoveries & therapeutics 13- (4) 207 -211 2019
乳酸菌加熱死菌体と発酵βグルカン誘導腹腔内細胞の組み合わせによるCandida albicans菌糸形発育の阻止
羽山 和美; 鈴木 基文; 久下 高生; 岩佐 広行; 関水 和久; 安部 茂 Medical Mycology Research 9- (1) 3 -8 2018/12
Bacterial polysaccharides inhibit sucrose-induced hyperglycemia in silkworms.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 12- (4) 185 -188 2018/09
Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 1768.
Suresh Panthee; Hiroshi Hamamoto; Sanae A Ishijima; Atmika Paudel; Kazuhisa Sekimizu Genome biology and evolution 10- (8) 2017 -2022 2018/08
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.
Tomohiro Maruyama; Takashi Baba; Yuki Maemoto; Chikako Hara-Miyauchi; Minami Hasegawa-Ogawa; Hirotaka James Okano; Yuki Enda; Kei Matsumoto; Nagisa Arimitsu; Kazuki Nakao; Hiroshi Hamamoto; Kazuhisa Sekimizu; Takayo Ohto-Nakanishi; Hiroki Nakanishi; Takeshi Tokuyama; Shigeru Yanagi; Mitsuo Tagaya; Katsuko Tani Cell death & disease 9- (8) 797 -797 2018/07
Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic.
Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue The Journal of organic chemistry 83- (13) 6924 -6935 2018/07
Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model.
Atmika Paudel; Suresh Panthee; Makoto Urai; Hiroshi Hamamoto; Tomohiko Ohwada; Kazuhisa Sekimizu Scientific reports 8- (1) 1578 -1578 2018/01
Estimation of lactic acid bacterial cell number by DNA quantification.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 12- (2) 88 -91 2018
[Platform Development for Drug Discovery Utilizing Silkworm towards "Novel Industrial Revolution"].
Kazuhisa Sekimizu; Kohji Itoh Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 138- (7) 861 -862 2018
[Development of Antibiotics Using Silkworm Bacteria and Fungi Infection Model].
Hiroshi Hamamoto; Kazuhisa Sekimizu Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 138- (7) 895 -899 2018
Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation system.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 12- (3) 122 -125 2018
Establishment of a gnotobiotic silkworm model.
Hiroto Nakajima; Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 12- (5) 291 -294 2018
昆虫モデルを用いた緑膿菌感染に対するプロバイオティクス効果の解析
西田 智; 関水 和久; 斧 康雄 緑膿菌感染症研究会講演記録 51回- 80 -83 2017/12
昆虫モデルを用いた緑膿菌感染に対するプロバイオティクス効果の解析
西田智; 関水和久; 関水和久; 斧康雄 緑膿菌感染症研究会講演記録 51st- 80‐83 -83 2017/12
In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms.
Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi Pharmaceutical biology 55- (1) 1256 -1262 2017/12
Structural analysis of an innate immunostimulant from broccoli, Brassica oleracea var. italica.
Makoto Urai; Keiko Kataoka; Satoshi Nishida; Kazuhisa Sekimizu Drug discoveries & therapeutics 11- (5) 230 -237 2017/11
Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from Rhizobium sp. strain M2 screened using a silkworm muscle contraction assay.
Makoto Urai; Tomoko Aizawa; Katsutoshi Imamura; Hiroshi Hamamoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 11- (5) 238 -245 2017/11
Two-spotted cricket as an animal infection model of human pathogenic fungi.
Yuto Kochi; Yasuhiko Matsumoto; Kazuhisa Sekimizu; Chikara Kaito Drug discoveries & therapeutics 11- (5) 259 -266 2017/11
Isolation of antibiotic-producing Pseudomonas species with low-temperature cultivation of temperate soil.
Shuhei Mitsutomi; Kazuhisa Sekimizu; Chikara Kaito Drug discoveries & therapeutics 11- (5) 267 -275 2017/11
Evaluation of the innate immune-stimulating activity of amazake using a silkworm muscle contraction assay.
Hiroko Maruki-Uchida; Masahiko Sai; Kazuhisa Sekimizu Drug discoveries & therapeutics 11- (5) 288 -290 2017/11
An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis.
Masaki Ishii; Yasuhiko Matsumoto; Tsuyoshi Yamada; Shigeru Abe; Kazuhisa Sekimizu Scientific reports 7- (1) 12289 -12289 2017/09
Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions.
Haruka Fujino; Masanori Nagatomo; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue Angewandte Chemie (International ed. in English) 56- (39) 11865 -11869 2017/09
D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus.
Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu The Journal of antibiotics 70- (8) 907 -910 2017/07
Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus.
Fumiaki Tabuchi; Yasuhiko Matsumoto; Masaki Ishii; Keita Tatsuno; Mitsuhiro Okazaki; Tomoaki Sato; Kyoji Moriya; Kazuhisa Sekimizu The Journal of antibiotics 70- (6) 771 -774 2017/06
Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b.
Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu Genome announcements 5- (22) 2017/06
Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori).
Kantaporn Kheawfu; Surachai Pikulkaew; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi Drug discoveries & therapeutics 11- (2) 64 -69 2017/05
Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract.
Pimporn Anantaworasakul; Hiroshi Hamamoto; Kazuhisa Sekimizu; Siriporn Okonogi Drug discoveries & therapeutics 11- (2) 70 -77 2017/05
Genomic analysis of vancomycin-resistant Staphylococcus aureus VRS3b and its comparison with other VRSA isolates.
Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Kazuhisa Sekimizu Drug discoveries & therapeutics 11- (2) 78 -83 2017/05
Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis.
Akiho Yagi; Ryuji Uchida; Hiroshi Hamamoto; Kazuhisa Sekimizu; Ken-Ichi Kimura; Hiroshi Tomoda The Journal of antibiotics 70- (5) 685 -690 2017/05
Lactic acid bacteria of the Leuconostoc genus with high innate immunity-stimulating activity.
Masaki Ishii; Satoshi Nishida; Keiko Kataoka; Yayoi Nishiyama; Shigeru Abe; Kazuhisa Sekimizu Drug discoveries & therapeutics 11- (1) 25 -29 2017/03
Decreased sugar concentration in vegetable and fruit juices by growth of functional lactic acid bacteria.
Masaki Ishii; Yasuhiko Matsumoto; Satoshi Nishida; Kazuhisa Sekimizu Drug discoveries & therapeutics 11- (1) 30 -34 2017/03
Silkworm fungal infection model for identification of virulence genes in pathogenic fungus and screening of novel antifungal drugs.
Masaki Ishii; Yasuhiko Matsumoto; Ikuko Nakamura; Kazuhisa Sekimizu Drug discoveries & therapeutics 11- (1) 1 -5 2017/03
In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-5.
Suresh Panthee; Hiroshi Hamamoto; Yutaka Suzuki; Kazuhisa Sekimizu The Journal of antibiotics 70- (2) 204 -207 2017/02
Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection.
Ikuko Nakamura; Ryuichi Kanasaki; Koji Yoshikawa; Shigetada Furukawa; Akihiko Fujie; Hiroshi Hamamoto; Kazuhisa Sekimizu The Journal of antibiotics 70- (1) 41 -44 2017/01
Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents.
Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu Frontiers in microbiology 8- 373 -373 2017
Lactobacillus paraplantarum 11-1 Isolated from Rice Bran Pickles Activated Innate Immunity and Improved Survival in a Silkworm Bacterial Infection Model.
Satoshi Nishida; Masaki Ishii; Yayoi Nishiyama; Shigeru Abe; Yasuo Ono; Kazuhisa Sekimizu Frontiers in microbiology 8- 436 -436 2017
[Development of Novel Antibiotic Lysocin E Identified by Silkworm Infection Model].
Hiroshi Hamamoto; Kazuhisa Sekimizu Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 137- (4) 389 -392 2017
[The Usefulness of Silkworms as a Model Animal for Evaluating the Effectiveness of Medicine and Food].
Kazuhisa Sekimizu Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 137- (5) 551 -562 2017
A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus.
Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Keiichi Kaneko; Shigeki Matsunaga; Motomu Kanai; Yutaka Suzuki; Kazuhisa Sekimizu Frontiers in microbiology 8- 712 -712 2017
[A Silkworm Infection Model to Evaluate Antifungal Drugs for Cryptococcosis].
Yasuhiko Matsumoto; Masaki Ishii; Kiminori Shimizu; Susumu Kawamoto; Kazuhisa Sekimizu Medical mycology journal 58- (4) E131-E137 2017
昆虫を用いた緑膿菌感染モデルにおける乳酸菌による感染死抑制効果
西田智; 斧康雄; 関水和久; 関水和久 緑膿菌感染症研究会講演記録 50回- 112 -118 2016/12
Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity.
Takuya Kaji; Motoki Murai; Hiroaki Itoh; Jyunichiro Yasukawa; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue Chemistry (Weinheim an der Bergstrasse, Germany) 22- (47) 16912 -16919 2016/11
Lysobacter species: a potential source of novel antibiotics.
Suresh Panthee; Hiroshi Hamamoto; Atmika Paudel; Kazuhisa Sekimizu Archives of microbiology 198- (9) 839 -45 2016/11
A silkworm infection model to investigate Vibrio vulnificus virulence genes.
Mai Yamamoto; Takashige Kashimoto; Yukihiro Yoshimura; Nao Tachibana; Shiho Kuroda; Yoshiko Miki; Sou Kitabayashi; Ping Tong; Jianbo Xiao; Koichi Tanaka; Hiroshi Hamamoto; Kazuhisa Sekimizu; Koichiro Yamamoto Molecular medicine reports 14- (5) 4243 -4247 2016/11
Novel Nucleoside Diphosphatase Contributes to Staphylococcus aureus Virulence.
Kenta Imae; Yuki Saito; Hayato Kizaki; Hiroki Ryuno; Han Mao; Atsushi Miyashita; Yutaka Suzuki; Kazuhisa Sekimizu; Chikara Kaito The Journal of biological chemistry 291- (36) 18608 -18619 2016/09
A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus.
Yuto Kochi; Atsushi Miyashita; Kohsuke Tsuchiya; Masao Mitsuyama; Kazuhisa Sekimizu; Chikara Kaito FEMS microbiology letters 363- (15) 2016/08
Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus.
Atsushi Miyashita; Hayato Kizaki; Kazuhisa Sekimizu; Chikara Kaito Biology open 5- (6) 770 -6 2016/06
An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia.
Yasuhiko Matsumoto; Masaki Ishii; Kazuhisa Sekimizu Scientific reports 6- 26354 -26354 2016/05
乳酸菌によるカイコの細菌感染死の抑制
西田 智; 斧 康雄; 関水 和久 感染症学雑誌 90- (3) 434 -435 2016/05
A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus.
Yasuhiko Matsumoto; Jyunichiro Yasukawa; Masaki Ishii; Yohei Hayashi; Shinya Miyazaki; Kazuhisa Sekimizu Scientific reports 6- 22894 -22894 2016/03
Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (1) 9 -13 2016/02
A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine.
Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (1) 14 -8 2016/02
Identification of lysocin E using a silkworm model of bacterial infection.
Hiroshi Hamamoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (1) 24 -9 2016/02
Evaluation of anti-diabetic drugs by using silkworm, Bombyx mori.
Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (1) 19 -23 2016/02
Using silkworms as a laboratory animal to evaluate medicines and foods.
Kazuhisa Sekimizu; Hiroshi Hamamoto Drug discoveries & therapeutics 10- (1) 1 -2 2016/02
Using silkworms to establish alternative animal models for evaluation of drug-induced tissue injury.
Yoshinori Inagaki; Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (1) 40 -3 2016/02
Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm.
Satoshi Nishida; Yasuo Ono; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (1) 49 -56 2016/02
Acute oral toxicity test of chemical compounds in silkworms.
Kimihito Usui; Satoshi Nishida; Takuya Sugita; Takuro Ueki; Yasuhiko Matsumoto; Hidenobu Okumura; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (1) 57 -61 2016/02
Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins.
Hirono Yoshikai; Hayato Kizaki; Yuki Saito; Yosuke Omae; Kazuhisa Sekimizu; Chikara Kaito The Journal of infectious diseases 213- (2) 295 -304 2016/01
An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces.
Masakazu Nakadai; Shuta Tomida; Kazuhisa Sekimizu Scientific reports 6- 18543 -18543 2016/01
No Effect of Body Size on the Frequency of Calling and Courtship Song in the Two-Spotted Cricket, Gryllus bimaculatus.
Atsushi Miyashita; Hayato Kizaki; Kazuhisa Sekimizu; Chikara Kaito PloS one 11- (1) e0146999 2016
Menaquinone as a potential target of antibacterial agents.
Atmika Paudel; Hiroshi Hamamoto; Suresh Panthee; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (3) 123 -8 2016
Dividing phase-dependent cytotoxicity profiling of human embryonic lung fibroblast identifies candidate anticancer reagents.
Yoshinori Inagaki; Yasuhiko Matsumoto; Wei Tang; Kazuhisa Sekimizu Drug discoveries & therapeutics 10- (4) 195 -200 2016
Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading.
Hayato Kizaki; Yosuke Omae; Fumiaki Tabuchi; Yuki Saito; Kazuhisa Sekimizu; Chikara Kaito PloS one 11- (10) e0164523 2016
16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus.
Tatsuhiko Kyuma; Hayato Kizaki; Hiroki Ryuno; Kazuhisa Sekimizu; Chikara Kaito Biochimie 119- 166 -74 2015/12
Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.
Kenichi Ishii; Fumiaki Tabuchi; Miki Matsuo; Keita Tatsuno; Tomoaki Sato; Mitsuhiro Okazaki; Hiroshi Hamamoto; Yasuhiko Matsumoto; Chikara Kaito; Tetsuji Aoyagi; Keiichi Hiramatsu; Mitsuo Kaku; Kyoji Moriya; Kazuhisa Sekimizu Scientific reports 5- 17092 -17092 2015/11
A novel mutation in the vraS gene of Staphylococcus aureus contributes to reduce susceptibility against daptomycin.
Jie Su; Maki Iehara; Jyunichiro Yasukawa; Yasuhiko Matsumoto; Hiroshi Hamamoto; Kazuhisa Sekimizu The Journal of antibiotics 68- (10) 646 -8 2015/10
Niemann-Pick disease type C2 protein induces autophagy and inhibits growth in FM3A breast cancer cells.
Tatsuo Adachi; Yasuhiko Matsumoto; Yoshinori Inagaki; Kazuhisa Sekimizu Drug discoveries & therapeutics 9- (4) 282 -8 2015/08
Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies.
Kenichi Ishii; Hiroshi Hamamoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 9- (4) 238 -46 2015/08
Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity.
Masaki Ishii; Yasuhiko Matsumoto; Kazuhisa Sekimizu Drug discoveries & therapeutics 9- (4) 234 -7 2015/08
Ribosomal RNA methyltransferases contribute to Staphylococcus aureus virulence.
Tatsuhiko Kyuma; Satoshi Kimura; Yuichi Hanada; Tsutomu Suzuki; Kazuhisa Sekimizu; Chikara Kaito The FEBS journal 282- (13) 2570 -84 2015/07
カイコを利用する創薬イノベーションと未来 カイコモデルを用いた治療効果を有する新規抗菌薬の同定と開発
浜本 洋; 石井 健一; 安川 淳一朗; 西田 智; 関水 和久 日本薬学会年会要旨集 135年会- (1) 150 -150 2015/03
カイコをモデル宿主とする自然免疫・感染症研究の最前線:─昆虫サイトカインParalytic peptideの機能解明を中心に─
石井 健一; 浜本 洋; 関水 和久 Journal of Insect Biotechnology and Sericology 84- (3) 3_173 -3_179 2015
カイコを用いた創薬研究
松本靖彦; 浜本洋; 西田智; 関水和久 生体の科学 65- (6) 613 -620 2014/12
[Invited]
新規抗生物質カイコシンEの治療効果の基礎となる分子メカニズム
安川淳一朗; 浜本洋; ジー スー; パウデル アトミカ; 浦井誠; 西田智; 関水和久 日本生化学会大会(Web) 87th- 4T13A-09(3P-023) (WEB ONLY) -09] 2014/10
血清因子による新規抗生物質カイコシンの抗菌活性促進
安川淳一朗; 浜本洋; SU Jie; ATMIKA Paudel; 浦井誠; 石井健一; 安達健朗; 西田智; 関水和久 日本細菌学雑誌 69- (1) 135 -135 2014/02
Evaluation of lactic acid bacteria activating innate immunity using silkworm
NISHIDA Satoshi; ISHII Kennichi; HAMAMOTO Hiroshi; SEKIMIZU Kazuhisa; SEKIMIZU Kazuhisa Alternatives to Animal Testing and Experimentation 19- (Supplement) 2014
黄色ブドウ球菌の病原性に寄与する新規ヌクレオシド二リン酸分解酵素の同定
宮下惇嗣; 今江健太; 木崎速人; 斎藤祐樹; 毛瀚; 関水和久; 垣内力 日本生化学会大会(Web) 87th- [4T08p -04] 2014
rRNAのメチル化による翻訳忠実性の維持が黄色ブドウ球菌の病原性に寄与する
久間 達彦; 木村 聡; 鈴木 勉; 関水 和久; 垣内 力 日本生化学会大会プログラム・講演要旨集 86回- 3T14a -13 2013/09
カイコ細菌感染モデルを用いた治療有効な新規抗生物質カイコシンの作用機序解析
安川淳一朗; 浜本洋; SU Jie; PAUDEL Atmika; 浦井誠; 西田智; 関水和久 日本生化学会大会(Web) 86回- 2T19a -05 2013/09
新規機能性RNA psm-mecはagrA遺伝子の翻訳を抑制してメチシリン耐性黄色ブドウ球菌の病原性を抑制する
幾尾 真理子; 齋藤 裕樹; 大前 陽輔; 毛 瀚; 長野 源太郎; 藤幸 知子; 沼田 俊介; 韓 笑; 小幡 佳津明; 長谷川 節雄; 山口 博樹; 猪口 孝一; 伊藤 輝代; 平松 啓一; 伊藤 孝司; 関水 和久; 垣内 力 日本生化学会大会プログラム・講演要旨集 86回- 3T14a -14 2013/09
カイコを用いた新規医薬品と評価システムの開発 カイコ病態モデルを利用した医薬品の探索研究
浜本 洋; 石川 繭子; 瀬筒 秀樹; 坪田 拓也; 片岡 啓子; 松本 靖彦; 垣内 力; 関水 和久 日本薬学会年会要旨集 133年会- (1) 178 -178 2013/03
Development of an alternative method of acute oral toxicity tests using silkworm Part 2
SUGITA Takuya; YAMAMOTO Yutaka; UEKI Takuro; NISHIDA Satoshi; HAMAMOTO Hiroshi; MATSUMOTO Yasuhiko; SEKIMIZU Kazuhisa; SEKIMIZU Kazuhisa; OKUMURA Hidenobu Alternatives to Animal Testing and Experimentation 18- (Supplement) 2013
無脊椎動物における適応免疫機構
宮下惇嗣; 川崎清史; 関水和久; 垣内力 日本生化学会大会(Web) 86th- 1T18p -02 2013
カイコにおいてリポ多糖を認識するブースター反応が感染防御に寄与する
宮下惇嗣; 関水和久; 垣内力 日本細菌学雑誌 68- (1) 204 -204 2013
LPSトランスポーターの変異による大腸菌の高病原性化
吉海周; 若松愛; 若松愛; 宮下惇嗣; 松本靖彦; 磯貝隆夫; 関水和久; 垣内力 日本生化学会大会(Web) 86th- 1T18p -01 2013
高血糖カイコ感染モデルによる糖尿病宿主に対する病原性に必要な細菌の遺伝子の同定
宮崎 真也; 松本 靖彦; 林 陽平; 坂上 徹; 垣内 力; 龍野 桂太; 岡崎 充宏; 奥川 周; 森屋 恭爾; 関水 和久 日本細菌学雑誌 67- (1) 105 -105 2012/02
none
Keigo UENO; Yasuhiko MATSUMOTO; Kazuhisa SEKIMIZU; Yuki KINJO; Hiroji CHIBANA KAGAKU TO SEIBUTSU 50- (5) 320 -321 2012
[Invited]
Evaluation of anti-diabetic drugs using silkworm, Bombyx mori.
Yasuhiko Matsumoto; Eriko Sumiya; Takuya Sugita; Kazuhisa Sekimizu YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 128- 87 -87 2008
哺乳動物細胞における,DNA topoisomerase IIαの活性低下によるアポトーシスの誘導
嘉村 格士郎; 秋光 信佳; 刀祢 重信; 阪口 亜矢子; 菊池 韶彦; 浜本 洋; 関水 和久 日本薬学会年会要旨集 123年会- (3) 132 -132 2003/03
ノックアウトマウスを用いたグライコフォリンAの生体内機能に関する研究
有光 なぎさ; 秋光 信佳; 浜本 洋; 関水 和久 日本薬学会年会要旨集 121年会- (4) 21 -21 2001/03
黄色ブドウ球菌DnaA蛋白質の精製に関する研究
嘉村 格士郎; 秋光 信佳; 片山 秀樹; 松尾 美記; 関水 和久 日本薬学会年会要旨集 121年会- (4) 51 -51 2001/03
赤血球へのマウスマラリア原虫の侵入におけるDuffy蛋白質の役割に関する研究
福間 信子; 秋光 信佳; 金 惠淑; 小野 華奈子; 有光 なぎさ; 浜本 洋; 綿矢 有佑; 関水 和久 日本薬学会年会要旨集 121年会- (4) 78 -78 2001/03
黄色ブドウ球菌dnaB遺伝子の温度感受性変異株の分離
垣内 力; 井上 隆一; 田邊 舞子; Hossain Muktadir Shahid; 洞田 佳範; 秋光 信佳; 関水 和久 日本薬学会年会要旨集 121年会- (4) 52 -52 2001/03
P176 Study of essential erythroid proteins for rodent malaria invasion
AKIMITSU Nobuyoshi; KIM Hye-Sook; FUKUMA Nobuko; ARIMITSU Nagisa; ONO Kanako; HAMAMOTO Hiroshi; WATAYA Yusuke; SEKIMIZU Kazuhisa Med. Entomol. Zool. 52- (0) 121 -121 2001
ヒト末梢血白血球におけるHSP70の誘導に関する研究
下山 真智子; 秋光 信佳; 浜本 洋; 関水 和久 日本薬学会年会要旨集 120年会- (4) 79 -79 2000/03
細胞接触によるES細胞のアポトーシスの抑制に関する研究
大場 暁子; 秋光 信佳; 関水 和久 生化学 70- (8) 943 -943 1998/08
MRSAの消毒剤耐性変異の獲得によるβ-ラクタム系抗生物質に対する耐性度の上昇
庄子 幹郎; 浜本 洋; 竹森 紘一; 濱崎 直孝; 赤峰 昭文; 秋光 信佳; 関水 和久 日本薬学会年会要旨集 118年会- (3) 158 -158 1998/03
Research Grants & Projects
食品由来の強力な自然免疫活性化能を示す新規物質の作用機序解析
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2021/04 -2024/03
Author :
関水 和久; 宮下 惇嗣; 浜本 洋
Comprehensive analysis of pathogenic ncRNA in host environment
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2017/10 -2020/03
Author :
関水 和久; PANTHEE SURESH
Platform for the identification of novel therapeutically effective antimicrobial agents
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2015/05 -2020/03
Author :
Kazuhisa Sekimizu
Comprehensive understanding of bacterial adaptation mechanism in diabetic host
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2014/04 -2017/03
Author :
Matsumoto Yasuhiko; SEKIMIZU KAZUHISA
治療効果を指標に同定された新規抗菌薬の作用機序解析
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2013/04 -2015/03
Author :
関水 和久; PAUDEL Atmika
新規リポペプチド系抗生物質カイコシンの標的同定
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2012/04 -2014/03
Author :
関水 和久
Establishment of screening system for antifungal drugs using silkworm fungus infection model
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2012/04 -2014/03
Author :
SEKIMIZU Kazuhisa; HAMAMOTO Hiroshi
Understanding of host-pathogen interaction by using silkworm infection model
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2011/04 -2014/03
Author :
SEKIMIZU Kazuhisa; KAITO Chikara; MATSUMOTO Yasuhiko
Development of novel molecular-targeted medicine against aminopeptidase
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2009 -2011
Author :
KARAKO Takashi; KOKUDO Norihiro; SEKIMIZU Kazuhisa; NAKATA Munehiro
新規病原性遺伝子群を基盤とする病原性発現コアシステムの把握
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2009 -2010
Author :
関水 和久
Elucidation of bacterial pathogenesis system based on a silkworm infection model
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2008 -2010
Author :
SEKIMIZU Kazuhisa; KAITO Chikara
肝細胞がん特有の進行メカニズムに着目した新規化学療法剤の開発
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2008 -2009
Author :
唐子 堯; 國土 典宏; 関水 和久; 中田 宗宏
カイコ感染モデルを用いたグラム陽性細菌に保存された病原性発現機構の解明
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2007 -2008
Author :
関水 和久; 垣内 力
黄色ブドウ球菌の滑走能低下を指標とした抗菌治療薬に関する研究
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2007 -2007
Author :
関水 和久; 伊藤 貴浩; 垣内 力
カイコ幼虫における薬物動態に関する研究
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2005 -2006
Author :
関水 和久
ヒトに対する病原性細菌の感染モデルとしてのカイコ幼虫の有用性に関する研究
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2003 -2003
Author :
関水 和久
Functions of transcription elongation factor S-II for cell stress response and development
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2002 -2003
Author :
SEKIMIZU Kazuhisa; ITOH Takahiro
マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2002 -2003
Author :
関水 和久; 伊藤 貴浩; 黒川 健児; 秋光 信佳
マウス初期胚におけるDNAトポイソメラーゼII依存チェックポイント機能低下の可能性
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2002 -2002
Author :
関水 和久; 秋光 信佳
マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2001 -2001
Author :
関水 和久; 秋光 信佳
消毒剤耐性変異の獲得に伴うMRSAのβラクタム系抗生物質耐性の上昇
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
2000 -2001
Author :
関水 和久; 久保 健雄
Development of antibiotics by monitoring the inhibition of the ATP-binding to DnaA, the initiator protein of chromosomal DNA replication in bacteria
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
2000 -2001
Author :
SEKIMIZU Kazuhisa
Study of the regulatory mechanism of DnaA protein, the initiator of DNA replication in Escherichia coli.
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1999 -2000
Author :
SEKIMIZU Kazuhisa; KUBO Takeo
Interaction between the replicational initiator DnaA and the DNA polymerase components
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1998 -1999
Author :
KATAYAMA Tsutomu; MIKI Takeyoshi; SEKIMIZU Kazuhisa
Development of Anti-malarial Drug and it's Molecular Target
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1996 -1999
Author :
WATAYA Yusuke; KITA Kiyoshi; ITAI Akiko; MATSUDA Akira; SEKIMIZU Kazuhisa; KIMURA Masatsugu; MORIYAMA Yoshiuori
Molecular design of inhibitors for DNA replication in Escherichia coli
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1997 -1998
Author :
SEKIMIZU Kazuhisa; MIKI Takeyoshi; SASAKI Shigeki
マウス個体レベルでの分子シャペロンのDNA超ら旋構造調節に関する分子
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1997 -1997
Author :
関水 和久; 勝木 元也
染色体の複製開始の頻度と同時性の制御装置
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1997 -1997
Author :
片山 勉; 三木 健良; 関水 和久
ストレス誘導性のDNAトポロジー変化のヒト細胞での解析
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1996 -1997
Author :
関水 和久; 早川 浩
Changes of DNA supercoiling in Escherichia coli induced by stress
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1996 -1997
Author :
SEKIMIZU Kazuhisa
大腸菌DnaAタンパク質機能の制御装置の分子機構
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1996 -1996
Author :
片山 勉; 水島 徹; 関水 和久
Screening of inhibitors of DNA replication by using the oriC plasmid replication system of Escherichia coli
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1994 -1996
Author :
SEKIMIZU Kazuhisa; KOBAYAKAWA Takahiro; SASAKI Shigetaka; MIKI Takeyoshi
Biochemical and genetic study of the regulatory mechanism of the chromosomal DNA replication in Escherichia coli
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1994 -1995
Author :
SEKIMIZU Kazuhisa; MIKI Takeyoshi
Principle of Stress Response
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1993 -1995
Author :
YAHARA Ichiro; SEKIMIZU Kazuhisa; NAKAMURA Yoshikazu; SHINAGAWA Hideo; ITO Koreaki; ISHIHAMA Akira
Screaning of E.coli Genes That Participate in the Partitioning of F Plasmid DNA
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1993 -1994
Author :
MIKI Takeyoshi; SEKIMIZU Kazuhisa
A study of the topological change of DNA in Escherichia coli induced by heat shock.
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1992 -1993
Author :
SEKIMIZU Kazuhisa
Studies on the conformation and functions of ras-related low Mr GTP-binding proteins.
Japan Society for the Promotion of Science:
Grants-in-Aid for Scientific Research
Date (from‐to) :
1991 -1992
Author :
NOZAWA Yoshinori; MATSUMOTO Kunihiro; YAMAMOTO Masayuki; NARUMIYA Shuh; KATADA Toshiaki; TAKAI Yoshimi
大学における研究設備の整備充実に関する調査研究
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1991 -1991
Author :
久城 育夫; 小宮山 進; 関水 和久; 塩田 邦郎; 脊山 洋右; 岸尾 光二
X線構造解析のためのDNA複製開始系蛋白質dnaAの結晶化
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1990 -1990
Author :
佐藤 能雅; 関水 和久
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1990 -1990
Author :
花岡 文雄; 田矢 洋一; 野瀬 清; 関水 和久; 井出 利憲; 西島 正弘
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1989 -1989
Author :
花岡 文雄; 田矢 洋一; 野瀬 清; 関水 和久; 井出 利憲; 西島 正弘
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
日本学術振興会:
科学研究費助成事業
Date (from‐to) :
1988 -1988
Author :
花岡 文雄; 井出 利憲; 関水 和久; 野瀬 清; 田矢 洋一; 西島 正弘