Tamura Atsushi

Researcher Information

Affiliation

Preclinical Medicine Associate Professor
Department of Pharmacology Associate Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202001003064405980

J-Global ID

• 202001003064405980

Research Areas

• Life sciences / Cell biology

Research Activity Information

Published Papers

• Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons.

  Gen Shiratsuchi; Satoshi Konishi; Tomoki Yano; Yuichi Yanagihashi; Shogo Nakayama; Tatsuya Katsuno; Hiroka Kashihara; Hiroo Tanaka; Kazuto Tsukita; Koya Suzuki; Elisa Herawati; Hitomi Watanabe; Toyohiro Hirai; Takeshi Yagi; Gen Kondoh; Shimpei Gotoh; Atsushi Tamura; Sachiko Tsukita

  EMBO reports 25 (3) 1176 - 1207 2024/03
• Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice.

  Koya Suzuki; Kosuke Yamaga; Reitaro Tokumasu; Tatsuya Katsuno; Hiroo Tanaka; Shuhei Chiba; Takeshi Yagi; Ichiro Katayama; Atsushi Tamura; Hiroyuki Murota; Sachiko Tsukita

  Annals of the New York Academy of Sciences 1523 (1) 51 - 61 2023/03
• Phase separation of an actin nucleator by junctional microtubules regulates epithelial function.

  Kazuto Tsukita; Manabu Kitamata; Hiroka Kashihara; Tomoki Yano; Ikuko Fujiwara; Timothy F Day; Tatsuya Katsuno; Jaewon Kim; Fumiko Takenaga; Hiroo Tanaka; Sungsu Park; Makoto Miyata; Hitomi Watanabe; Gen Kondoh; Ryosuke Takahashi; Atsushi Tamura; Sachiko Tsukita

  Science advances 9 (7) eadf6358  2023/02
• Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs

  Ko Sato; Ikumi Matsumoto; Koya Suzuki; Atsushi Tamura; Aki Shiraishi; Hiroshi Kiyonari; Jun Kasamatsu; Hideki Yamamoto; Tomomitsu Miyasaka; Daiki Tanno; Anna Miyahara; Tong Zong; Takafumi Kagesawa; Akiho Oniyama; Kotone Kawamura; Yuki Kitai; Aya Umeki; Emi Kanno; Hiromasa Tanno; Keiko Ishii; Sachiko Tsukita; Kazuyoshi Kawakami

  Scientific Reports Springer Science and Business Media LLC 11 (1) 2021/12
• Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules.

  Yoshiyuki Ozono; Atsushi Tamura; Shogo Nakayama; Elisa Herawati; Yukiko Hanada; Kazuya Ohata; Maki Takagishi; Masahide Takahashi; Takao Imai; Yumi Ohta; Kazuo Oshima; Takashi Sato; Hidenori Inohara; Sachiko Tsukita

  Scientific reports 11 (1) 20224 - 20224 2021/10
• Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.

  Shogo Nakayama; Tomoki Yano; Toshinori Namba; Satoshi Konishi; Maki Takagishi; Elisa Herawati; Tomoki Nishida; Yasuo Imoto; Shuji Ishihara; Masahide Takahashi; Ken'ya Furuta; Kazuhiro Oiwa; Atsushi Tamura; Sachiko Tsukita

  The Journal of cell biology 220 (7) 2021/07
• A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction.

  Tomoki Yano; Kazuto Tsukita; Hatsuho Kanoh; Shogo Nakayama; Hiroka Kashihara; Tomoaki Mizuno; Hiroo Tanaka; Takeshi Matsui; Yuhei Goto; Akira Komatsubara; Kazuhiro Aoki; Ryosuke Takahashi; Atsushi Tamura; Sachiko Tsukita

  The EMBO journal 40 (2) e104712  2021/01
• Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair.

  Junichi Matsuo; Daisuke Douchi; Khine Myint; Naing Naing Mon; Akihiro Yamamura; Kazuyoshi Kohu; Dede Liana Heng; Sabirah Chen; Nur Astiana Mawan; Napat Nuttonmanit; Ying Li; Supriya Srivastava; Shamaine Wei Ting Ho; Nicole Yee Shin Lee; Hong Kai Lee; Makoto Adachi; Atsushi Tamura; Jinmiao Chen; Henry Yang; Ming Teh; Jimmy Bok-Yan So; Wei Peng Yong; Patrick Tan; Khay Guan Yeoh; Linda Shyue Huey Chuang; Sachiko Tsukita; Yoshiaki Ito

  Gut 70 (10) 1833 - 1846 2020/12
• Reciprocal Association between the Apical Junctional Complex and AMPK: A Promising Therapeutic Target for Epithelial/Endothelial Barrier Function?

  Kazuto Tsukita; Tomoki Yano; Atsushi Tamura; Sachiko Tsukita

  International journal of molecular sciences 20 (23) 2019/11 [Refereed]
  
• Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.

  Satoshi Konishi; Tomoki Yano; Hiroo Tanaka; Tomoaki Mizuno; Hatsuho Kanoh; Kazuto Tsukita; Toshinori Namba; Atsushi Tamura; Shigenobu Yonemura; Shimpei Gotoh; Hisako Matsumoto; Toyohiro Hirai; Sachiko Tsukita

  Life science alliance 2 (4) 2019/08 [Refereed]
  
• Morphologic determinant of tight junctions revealed by claudin-3 structures.

  Shun Nakamura; Katsumasa Irie; Hiroo Tanaka; Kouki Nishikawa; Hiroshi Suzuki; Yasunori Saitoh; Atsushi Tamura; Sachiko Tsukita; Yoshinori Fujiyoshi

  Nature communications 10 (1) 816 - 816 2019/02 [Refereed]
  
• The Claudins: From Tight Junctions to Biological Systems.

  Sachiko Tsukita; Hiroo Tanaka; Atsushi Tamura

  Trends in biochemical sciences 44 (2) 141 - 152 0968-0004 2019/02 [Refereed]
  
• Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling.

  Juan-Min Zha; Hua-Shan Li; Qian Lin; Wei-Ting Kuo; Zhi-Hui Jiang; Pei-Yun Tsai; Ning Ding; Jia Wu; Shao-Fang Xu; Yi-Tang Wang; Jian Pan; Xiu-Min Zhou; Kai Chen; Min Tao; Matthew A Odenwald; Atsushi Tamura; Sachiko Tsukita; Jerrold R Turner; Wei-Qi He

  Cellular and molecular gastroenterology and hepatology 7 (2) 255 - 274 2019 [Refereed]
  
• Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection.

  Koya Suzuki; Kazuhiro Sentani; Hiroo Tanaka; Tomoki Yano; Kazuo Suzuki; Masanobu Oshima; Wataru Yasui; Atsushi Tamura; Sachiko Tsukita

  Cellular and molecular gastroenterology and hepatology 8 (1) 119 - 142 2019 [Refereed]
  
• Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice.

  Hiroo Tanaka; Mitsunobu Imasato; Yuji Yamazaki; Kengo Matsumoto; Koshi Kunimoto; Julien Delpierre; Kirstin Meyer; Marino Zerial; Naho Kitamura; Mitsuhiro Watanabe; Atsushi Tamura; Sachiko Tsukita

  Journal of hepatology 69 (6) 1308 - 1316 0168-8278 2018/12 [Refereed]
  
• 胃のおける細胞間接着装置タイトジャンクションの長期障害と胃腫瘍の発生

  鈴木 浩也; 仙谷 和弘; 田中 啓雄; 矢野 智樹; 鈴木 和男; 田村 淳; 月田 早智子

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 91回 [3P - 279] 2018/09
• Claudin-3 Loss Causes Leakage of Sweat from the Sweat Gland to Contribute to the Pathogenesis of Atopic Dermatitis.

  Kosuke Yamaga; Hiroyuki Murota; Atsushi Tamura; Hirofumi Miyata; Masato Ohmi; Junichi Kikuta; Masaru Ishii; Sachiko Tsukita; Ichiro Katayama

  The Journal of investigative dermatology Elsevier B.V. 138 (6) 1279 - 1287 1523-1747 2018/06 [Refereed]
  
• エクリン汗腺の構造と動態観察による発汗制御メカニズムの解明

  室田 浩之; 谷 佐起; 山賀 康右; 小野 慧美; 田村 淳; 菊田 順一; 近江 雅人; 月田 早智子; 石井 優; 関口 清俊; 片山 一朗

  日本皮膚科学会雑誌 128 (5) 1173 - 1173 0021-499X 2018/05 [Refereed]
  
• Apical cytoskeletons and junctional complexes as a combined system in epithelial cell sheets.

  Tomoki Yano; Hatsuho Kanoh; Atsushi Tamura; Sachiko Tsukita

  Annals of the New York Academy of Sciences WILEY 1405 (1) 32 - 43 0077-8923 2017/10 [Refereed]
  
• Site-specific distribution of claudin-based paracellular channels with roles in biological fluid flow and metabolism.

  Hiroo Tanaka; Atsushi Tamura; Koya Suzuki; Sachiko Tsukita

  Annals of the New York Academy of Sciences WILEY 1405 (1) 44 - 52 0077-8923 2017/10 [Refereed]
  
• Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin.

  Reitaro Tokumasu; Atsushi Tamura; Sachiko Tsukita

  Tissue barriers Taylor and Francis Inc. 5 (3) e1336194  2168-8370 2017/07 [Refereed]
  
• IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.

  Pei-Yun Tsai; Bingkun Zhang; Wei-Qi He; Juan-Min Zha; Matthew A Odenwald; Gurminder Singh; Atsushi Tamura; Le Shen; Anne Sailer; Sunil Yeruva; Wei-Ting Kuo; Yang-Xin Fu; Sachiko Tsukita; Jerrold R Turner

  Cell host & microbe CELL PRESS 21 (6) 671 - 681 1931-3128 2017/06 [Refereed]
  
• Claudin-1の発現低下による皮膚恒常性の破綻

  山賀 康右; 室田 浩之; 片山 一朗; 徳増 玲太郎; 山崎 裕自; 鈴木 浩也; 田村 淳; 月田 早智子

  角化症研究会記録集 31 59 - 64 2017/03
• Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

  Kosuke Fujimoto; Makoto Kinoshita; Hiroo Tanaka; Daisuke Okuzaki; Yosuke Shimada; Hisako Kayama; Ryu Okumura; Yoki Furuta; Masashi Narazaki; Atsushi Tamura; Shigetsugu Hatakeyama; Masahito Ikawa; Kiichiro Tsuchiya; Mamoru Watanabe; Atsushi Kumanogoh; Sachiko Tsukita; Kiyoshi Takeda

  Mucosal immunology NATURE PUBLISHING GROUP 10 (2) 446 - 459 1933-0219 2017/03 [Refereed]
  
• Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis.

  Reitaro Tokumasu; Kosuke Yamaga; Yuji Yamazaki; Hiroyuki Murota; Koya Suzuki; Atsushi Tamura; Kana Bando; Yasuhide Furuta; Ichiro Katayama; Sachiko Tsukita

  Proceedings of the National Academy of Sciences of the United States of America NATL ACAD SCIENCES 113 (28) E4061-8 - E4068 0027-8424 2016/07 [Refereed]
  
• 汗腺の構造/機能解析の最前線 Claudin-3が汗腺からの汗の漏出を止める

  山賀 康右; 室田 浩之; 宮田 浩史; 近江 雅人; 菊田 順一; 石井 優; 田村 淳; 月田 早智子; 片山 一朗

  日本発汗学会総会プログラム・抄録集 日本発汗学会 24回 31 - 31 2016/07
• Water-based biological homeostasis in multiple fluid-filled compartments in the higher organisms: Regulation by the paracellular barrier-forming tight junctions of epithelial cell sheets

  Yuji Yamazaki; Atsushi Tamura; Sachiko Tsukita

  Water: The Forgotten Biological Molecule Pan Stanford Publishing Pte. Ltd. 247 - 258 2016/04
• Claudin-21 Has a Paracellular Channel Role at Tight Junctions.

  Hiroo Tanaka; Yasuko Yamamoto; Hiroka Kashihara; Yuji Yamazaki; Kazutoshi Tani; Yoshinori Fujiyoshi; Katsuhiko Mineta; Kosei Takeuchi; Atsushi Tamura; Sachiko Tsukita

  Molecular and cellular biology AMER SOC MICROBIOLOGY 36 (6) 954 - 64 0270-7306 2016/01 [Refereed]
  
• Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells.

  Toru Kamitani; Hirofumi Sakaguchi; Atsushi Tamura; Takenori Miyashita; Yuji Yamazaki; Reitaro Tokumasu; Ryuhei Inamoto; Ai Matsubara; Nozomu Mori; Yasuo Hisa; Sachiko Tsukita

  Scientific reports NATURE PUBLISHING GROUP 5 18402 - 18402 2045-2322 2015/12 [Refereed]
  
• Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice.

  Hiroo Tanaka; Maki Takechi; Hiroshi Kiyonari; Go Shioi; Atsushi Tamura; Sachiko Tsukita

  Gut BMJ PUBLISHING GROUP 64 (10) 1529 - 38 0017-5749 2015/10 [Refereed]
  
• Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice.

  Ryo Hatano; Kaori Akiyama; Atsushi Tamura; Shigekuni Hosogi; Yoshinori Marunaka; Michael J Caplan; Yoshiyuki Ueno; Sachiko Tsukita; Shinji Asano

  Hepatology (Baltimore, Md.) WILEY-BLACKWELL 61 (5) 1660 - 71 0270-9139 2015/05 [Refereed]
  
• Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin.

  Yasunori Saitoh; Hiroshi Suzuki; Kazutoshi Tani; Kouki Nishikawa; Katsumasa Irie; Yuki Ogura; Atsushi Tamura; Sachiko Tsukita; Yoshinori Fujiyoshi

  Science (New York, N.Y.) AMER ASSOC ADVANCEMENT SCIENCE 347 (6223) 775 - 8 0036-8075 2015/02 [Refereed]
  
• Model for the architecture of claudin-based paracellular ion channels through tight junctions.

  Hiroshi Suzuki; Kazutoshi Tani; Atsushi Tamura; Sachiko Tsukita; Yoshinori Fujiyoshi

  Journal of molecular biology ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD 427 (2) 291 - 7 0022-2836 2015/01 [Refereed]
  
• Paracellular barrier and channel functions of TJ claudins in organizing biological systems: advances in the field of barriology revealed in knockout mice.

  Atsushi Tamura; Sachiko Tsukita

  Seminars in cell & developmental biology ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD 36 177 - 85 1084-9521 2014/12 [Refereed]
  
• Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice.

  Kengo Matsumoto; Mitsunobu Imasato; Yuji Yamazaki; Hiroo Tanaka; Mitsuhiro Watanabe; Hidetoshi Eguchi; Hiroaki Nagano; Hayato Hikita; Tomohide Tatsumi; Tetsuo Takehara; Atsushi Tamura; Sachiko Tsukita

  Gastroenterology 147 (5) 1134 - 45 0016-5085 2014/11 [Refereed]
  
• Crystal structure of a claudin provides insight into the architecture of tight junctions.

  Hiroshi Suzuki; Tomohiro Nishizawa; Kazutoshi Tani; Yuji Yamazaki; Atsushi Tamura; Ryuichiro Ishitani; Naoshi Dohmae; Sachiko Tsukita; Osamu Nureki; Yoshinori Fujiyoshi

  Science (New York, N.Y.) AMER ASSOC ADVANCEMENT SCIENCE 344 (6181) 304 - 7 0036-8075 2014/04 [Refereed]
  
• Ezrin mediates neuritogenesis via down-regulation of RhoA activity in cultured cortical neurons.

  Yosuke Matsumoto; Masatoshi Inden; Atsushi Tamura; Ryo Hatano; Sachiko Tsukita; Shinji Asano

  PloS one PUBLIC LIBRARY SCIENCE 9 (8) e105435  1932-6203 2014 [Refereed]
  
• Fetal growth retardation and lack of hypotaurine in ezrin knockout mice.

  Tomohiro Nishimura; Kei Higuchi; Yoshimichi Sai; Yuki Sugita; Yuko Yoshida; Masatoshi Tomi; Masami Wada; Tomohiko Wakayama; Atsushi Tamura; Sachiko Tsukita; Tomoyoshi Soga; Emi Nakashima

  PloS one PUBLIC LIBRARY SCIENCE 9 (8) e105423  1932-6203 2014 [Refereed]
  
• The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK.

  Tomoki Yano; Takeshi Matsui; Atsushi Tamura; Masami Uji; Sachiko Tsukita

  The Journal of cell biology ROCKEFELLER UNIV PRESS 203 (4) 605 - 14 0021-9525 2013/11 [Refereed]
  
• Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition.

  Masami Wada; Atsushi Tamura; Nobuyuki Takahashi; Sachiko Tsukita

  Gastroenterology W B SAUNDERS CO-ELSEVIER INC 144 (2) 369 - 80 0016-5085 2013/02 [Refereed]
  
• Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3.

  Hisayoshi Hayashi; Atsushi Tamura; Devishree Krishnan; Sachiko Tsukita; Yuichi Suzuki; Hetal S Kocinsky; Peter S Aronson; John Orlowski; Sergio Grinstein; R Todd Alexander

  PloS one 8 (2) e55623  1932-6203 2013 [Refereed]
  
• EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.

  Zili Lei; Takako Maeda; Atsushi Tamura; Tetsuya Nakamura; Yuji Yamazaki; Hidetaka Shiratori; Kenta Yashiro; Sachiko Tsukita; Hiroshi Hamada

  Developmental biology ACADEMIC PRESS INC ELSEVIER SCIENCE 371 (2) 136 - 45 0012-1606 2012/11 [Refereed]
  
• Claudin-based paracellular proton barrier in the stomach.

  Atsushi Tamura; Yuji Yamazaki; Daisuke Hayashi; Koya Suzuki; Kazuhiro Sentani; Wataru Yasui; Sachiko Tsukita

  Annals of the New York Academy of Sciences BLACKWELL SCIENCE PUBL 1258 108 - 14 0077-8923 2012/07 [Refereed]
  
• Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice.

  Daisuke Hayashi; Atsushi Tamura; Hiroo Tanaka; Yuji Yamazaki; Shin Watanabe; Koya Suzuki; Kazuo Suzuki; Kazuhiro Sentani; Wataru Yasui; Hiromi Rakugi; Yoshitaka Isaka; Sachiko Tsukita

  Gastroenterology W B SAUNDERS CO-ELSEVIER INC 142 (2) 292 - 304 0016-5085 2012/02 [Refereed]
  
• Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet.

  Koshi Kunimoto; Yuji Yamazaki; Tomoki Nishida; Kyosuke Shinohara; Hiroaki Ishikawa; Toshiaki Hasegawa; Takeshi Okanoue; Hiroshi Hamada; Tetsuo Noda; Atsushi Tamura; Shoichiro Tsukita; Sachiko Tsukita

  Cell CELL PRESS 148 (1-2) 189 - 200 0092-8674 2012/01 [Refereed]
  
• Claudin-18の欠損はマウスのparacellar proton leak、IL-1の上昇、萎縮性胃炎を引き起こす(Deficiency of Claudin-18 cause paracellular proton leak,up-regulation IL-1and atrophic gastritis in mice)

  林 大祐; 田村 淳; 田中 啓雄; 山崎 裕自; 渡辺 慎; 鈴木 浩也; 鈴木 和男; 仙谷 和弘; 安井 弥; 猪阪 善隆; 楽木 宏実; 月田 早智子

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 84回 3P - 0565 2011/09
• Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine.

  Atsushi Tamura; Hisayoshi Hayashi; Mitsunobu Imasato; Yuji Yamazaki; Asuka Hagiwara; Masami Wada; Tetsuo Noda; Mitsuhiro Watanabe; Yuichi Suzuki; Sachiko Tsukita

  Gastroenterology W B SAUNDERS CO-ELSEVIER INC 140 (3) 913 - 23 0016-5085 2011/03 [Refereed]
  
• Novel expression of claudin-5 in glomerular podocytes.

  Ryo Koda; Linning Zhao; Eishin Yaoita; Yutaka Yoshida; Sachiko Tsukita; Atsushi Tamura; Masaaki Nameta; Ying Zhang; Hidehiko Fujinaka; Sameh Magdeldin; Bo Xu; Ichiei Narita; Tadashi Yamamoto

  Cell and tissue research SPRINGER 343 (3) 637 - 48 0302-766X 2011/03 [Refereed]
  
• Predicted expansion of the claudin multigene family.

  Katsuhiko Mineta; Yasuko Yamamoto; Yuji Yamazaki; Hiroo Tanaka; Yukiyo Tada; Kuniaki Saito; Atsushi Tamura; Michihiro Igarashi; Toshinori Endo; Kosei Takeuchi; Sachiko Tsukita

  FEBS letters ELSEVIER SCIENCE BV 585 (4) 606 - 12 0014-5793 2011/02 [Refereed]
  
• Water-based biological homeostasis in multiple fluid-filled compartments in the higher organisms: Regulation by the paracellular barrier-forming tight junctions of epithelial cell sheets

  Yuji Yamazaki; Atsushi Tamura; Sachiko Tsukita

  Water: The Forgotten Biological Molecule Pan Stanford Publishing Pte. Ltd. 247 - 258 2010/11 [Refereed]
  
• Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats.

  Kei Higuchi; Hisashi Iizasa; Yoshimichi Sai; Satomi Horieya; Kyeong-Eun Lee; Masami Wada; Masayuki Deguchi; Tomohiro Nishimura; Tomohiko Wakayama; Atsushi Tamura; Sachiko Tsukita; Noriko Kose; Young-Sook Kang; Emi Nakashima

  Biological & pharmaceutical bulletin PHARMACEUTICAL SOC JAPAN 33 (8) 1400 - 6 0918-6158 2010 [Refereed]
  
• Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function.

  Sachiko Tsukita; Tatsuya Katsuno; Yuji Yamazaki; Kazuaki Umeda; Atsushi Tamura; Shoichiro Tsukita

  Annals of the New York Academy of Sciences WILEY-BLACKWELL 1165 44 - 52 0077-8923 2009/05 [Refereed]
  
• ケラチン結合蛋白質Trichopleinの中心体における機能解析(Trichoplein, a keratin binding protein, is a functional component of centrosomes)

  大室 有紀[松山]; 鄒 鵬; 猪子 誠人; 衣斐 美歩; 米村 重信; 林 裕子; 森 大輔; 広常 真治; 田村 淳; 月田 早智子; 稲垣 昌樹

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 (公社)日本生化学会 81回・31回 4T12 - 6 2008/11
• Tight junction-based epithelial microenvironment and cell proliferation

  S. Tsukita; Y. Yamazaki; T. Katsuno; A. Tamura; S. Tsukita

  ONCOGENE NATURE PUBLISHING GROUP 27 (55) 6930 - 6938 0950-9232 2008/11 [Refereed]
  
• ケラチン結合タンパク質Trichopleinの中心体における機能解析(Trichoplein, a keratin binding protein, is a functional component of centrosomes)

  衣斐 美歩; 鄒 鵬; 猪子 誠人; 大室 有紀[松山]; 米村 重信; 林 裕子; 森 大輔; 広常 真治; 田村 淳; 月田 早智子; 稲垣 昌樹

  日本細胞生物学会大会講演要旨集 (一社)日本細胞生物学会 60回 122 - 122 2008/06
• Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.

  Tatsuya Katsuno; Kazuaki Umeda; Takeshi Matsui; Masaki Hata; Atsushi Tamura; Masahiko Itoh; Kosei Takeuchi; Toshihiko Fujimori; Yo-ichi Nabeshima; Tetsuo Noda; Shoichiro Tsukita; Sachiko Tsukita

  Molecular biology of the cell AMER SOC CELL BIOLOGY 19 (6) 2465 - 75 1059-1524 2008/06 [Refereed]
  
• Megaintestine in claudin-15-deficient mice.

  Atsushi Tamura; Yuka Kitano; Masaki Hata; Tatsuya Katsuno; Kazumasa Moriwaki; Hiroyuki Sasaki; Hisayoshi Hayashi; Yuichi Suzuki; Tetsuo Noda; Mikio Furuse; Shoichiro Tsukita; Sachiko Tsukita

  Gastroenterology W B SAUNDERS CO-ELSEVIER INC 134 (2) 523 - 34 0016-5085 2008/02 [Refereed]
  
• 細胞間接着における細胞膜 細胞骨格のインターフェースとしてのZO-1

  勝野 達也; 梅田 一彰; 山崎 裕自; 三宅 由華; 和田 真実; 松井 毅; 田村 淳; 池ノ内 順一; 古瀬 幹夫; 月田 承一郎; 月田 早智子

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 (公社)日本生化学会 80回・30回 4S15 - 3 2007/11
• Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3

  Kanehisa Fukumoto; Shojiro Kikuchi; Norio Itoh; Atsushi Tamura; Masaki Hata; Hisakazu Yamagishi; Shoichiro Tsukita; Sachiko Tsukita

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE ELSEVIER SCIENCE BV 1772 (3) 298 - 306 0925-4439 2007/03 [Refereed]
  
• Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3.

  Kanehisa Fukumoto; Shojiro Kikuchi; Norio Itoh; Atsushi Tamura; Masaki Hata; Hisakazu Yamagishi; Shoichiro Tsukita; Sachiko Tsukita

  Biochimica et biophysica acta 1772 (3) 298 - 306 0006-3002 2007/03 [Refereed]
  
• Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells.

  Atsushi Tamura; Shojiro Kikuchi; Masaki Hata; Tatsuya Katsuno; Takeshi Matsui; Hisayoshi Hayashi; Yuichi Suzuki; Tetsuo Noda; Shoichiro Tsukita; Sachiko Tsukita

  The Journal of cell biology ROCKEFELLER UNIV PRESS 169 (1) 21 - 8 0021-9525 2005/04 [Refereed]
  
• Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues

  A Inoko; M Itoh; A Tamura; M Matsuda; M Furuse; S Tsukita

  GENES TO CELLS WILEY-BLACKWELL 8 (11) 837 - 845 1356-9597 2003/11 [Refereed]
  
• Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes.

  Shojiro Kikuchi; Masaki Hata; Kanehisa Fukumoto; Yukari Yamane; Takeshi Matsui; Atsushi Tamura; Shigenobu Yonemura; Hisakazu Yamagishi; Dietrich Keppler; Shoichiro Tsukita; Sachiko Tsukita

  Nature genetics NATURE PUBLISHING GROUP 31 (3) 320 - 5 1061-4036 2002/07 [Refereed]
  
• Structural conversion between open and closed forms of radixin: Low-angle shadowing electron microscopy

  H Ishikawa; A Tamura; T Matsui; H Sasaki; T Hakoshima; S Tsukita; S Tsukita

  JOURNAL OF MOLECULAR BIOLOGY ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD 310 (5) 973 - 978 0022-2836 2001/07 [Refereed]
  

MISC

• Claudin-3の結晶構造が明らかにするタイトジャンクション形態の決定要素

  中村駿; 中村駿; 入江克雅; 入江克雅; 田中啓雄; 田村淳; 月田早智子; 藤吉好則; 藤吉好則  日本細胞生物学会大会(Web)  71st-  2019
• Down-regulation of Claudin-1 demonstrates the pathology of atopic dermatitis

  山賀 康右; 徳増 玲太郎; 室田 浩之; 田村 淳; 片山 一朗; 月田 早智子  臨床免疫・アレルギー科 = Clinical immunology & allergology  67-  (6)  599  -605  2017/06
• タイトジャンクションによる上皮細胞間バリア機能：クローディンを軸とした生体システム構築

  鈴木浩也; 田中啓雄; 田村淳; 月田早智子  実験医学  2017/04  [Invited]
  
• Claudin-3 is expressed in sweat glands and prevents the leakage of sweat

  K. Yamaga; H. Murota; A. Tamura; S. Tsukita; I. Katayama  JOURNAL OF INVESTIGATIVE DERMATOLOGY  136-  (5)  S120  -S120  2016/05
• Regulation of epithelial barrier function by a TJ-associated actin-binding protein.

  S. Konishi; M. Uji; T. Mizuno; K. Tateishi; H. Kanoh; T. Yano; A. Tamura; S. Tsukita  MOLECULAR BIOLOGY OF THE CELL  27-  2016
• TJ-MAP4 up-regulate MLC-phosphorylation by binding to MLC, ZO1 and tubulin at tight junction.

  H. Kanoh; T. Yano; M. Uji; A. Tamura; S. Tsukita  MOLECULAR BIOLOGY OF THE CELL  27-  2016
• タイトジャンクションをターゲットとした消化管疾患治療の可能性

  田村淳; 田中啓雄; 鈴木浩也; 月田早智子  G.I.Research  2015/12  [Invited]
  
• Regulation of epithelial morphorgenesis by a tight junction (TJ)-apical complex.

  S. Tsukita; T. Yano; H. Kanoh; A. Tamura  MOLECULAR BIOLOGY OF THE CELL  25-  2014/12
• Loss of Occludin caused mucociliary clearance defect with reduced number of multiciliated cells in mouse.

  E. Herawati; H. Tanaka; K. Tateishi; A. Tamura; S. Tsukita  MOLECULAR BIOLOGY OF THE CELL  25-  2014/12
• 胆管細胞におけるイオン輸送体の膜発現及び機能制御におけるezrinの役割

  波多野 亮; 秋山 香織; 田村 淳; 細木 誠之; 丸中 良典; 上野 義之; Caplan Michael; 月田 早智子; 浅野 真司  日本生化学会大会プログラム・講演要旨集  87回-  [2T14p  -07]  2014/10
• Casein Kinase 2 (CK2) Inhibition Limits Damage-Induced and Immune-Mediated Colitis by Distinct Mechanisms

  Ekaterina A. Khramtsova; Guohua Liang; Christopher R. Weber; Atsushi Tamura; Le Shen; Sachiko Tsukita; Jerrold R. Turner  GASTROENTEROLOGY  146-  (5)  S80  -S80  2014/05
• Stomach-type claudin18-deficient mouse spontaneously develops chronic gastritis, and associated with a part of carcinogenesis

  K. Suzuki; A. Tamura; S. Tsukita  MOLECULAR BIOLOGY OF THE CELL  24-  2013
• Cingulin-mediated association of microtubules with tight junctions and its regulation by AMPK

  T. Yano; T. Matsui; A. Tamura; M. Uji; S. Tsukita  MOLECULAR BIOLOGY OF THE CELL  24-  2013
• 腎リン酸再吸収におけるEzrinの生理的役割について

  波多野亮; 田村淳; 瀬川博子; 松原光伸; 宮本賢一; 月田早智子; 浅野真司  生化学  84回-  ROMBUNNO.3P-0277  -0277  2011/09
• Ezrinの腎リン酸再吸収における生理的役割

  波多野亮; 藤井詠子; 安倍真美; 田村淳; 月田早智子; 瀬川博子; 松原光伸; 浅野真司  日本薬学会年会要旨集  131st-  (3)  135  -135  2011/03
• Loss of basal feet on Odf2 deletion perturbs polarization of basal bodies.

  K. Kunimoto; Y. Yamazaki; T. Nishida; K. Shinohara; H. Ishikawa; T. Hasegawa; T. Okanoue; H. Hamada; T. Noda; A. Tamura; S. Tsukita; S. Tsukita  MOLECULAR BIOLOGY OF THE CELL  22-  2011
• 新規クローディン候補遺伝子群の予測と機能推定

  峯田克彦; 山本康子; 山本康子; 田中啓雄; 山崎裕自; 斎藤邦明; 田村淳; 武内恒成; 遠藤俊徳; 月田早智子  生化学  2010
• The role of paracellular Na+ permeability for Na+ -coupled glucose absorption

  Hisayoshi Hayashi; Kenta Nozaki; Atsushi Tamura; Sachiko Tsukita; Yuichi Suzuki  JOURNAL OF PHYSIOLOGICAL SCIENCES  60-  S59  -S59  2010
• PARACELLULAR CHANNEL-LIKE ROLE OF CLAUDINS : KNOCKOUT-MICE ANALYSES

  Sachiko Tsukita; Atsushi Tamura; Shoichiro Tsukita  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  86  -86  2009
• THE SODIUM ABSORPTION ASSOCIATED WITH ACTIVE GLUCOSE ABSORPTION IN PERFUSED MOUSE JEJUNUM IN VIVO

  Kenta Nozaki; Hisayoshi Hayashi; Atsushi Tamura; Sachiko Tsukita; Yuichi Suzuki  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  248  -248  2009
• EFFECTS OF PROSTONES ON TIGHT JUNCTIONS

  Atsushi Tamura; Ryuji Ueno; Sachiko Tsukita  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  88  -88  2009
• ERM(Ezrin/Radixin/Moesin)タンパク質におけるタンパク質間相互作用 (タンパク質間相互作用)

  田村 淳; 月田 早智子  生体の科学  58-  (5)  448  -450  2007/09
• 妊娠経過に伴う胎盤のezrin発現レベルと局在の変動

  樋口 慧; 和田 真実; 崔 吉道; 巨勢 典子; 田村 淳; 月田 早智子; 若山 友彦; 中島 恵美  薬剤学: 生命とくすり  67-  (Suppl.)  403  -403  2007/05
• ラット胎盤における妊娠経過に伴うezrinの発現量及び局在変動とP-gpの細胞内局在化への関与

  和田 真実; 崔 吉道; 巨勢 典子; 田村 淳; 月田 早智子; 若山 友彦; 上家 潤一; 大槻 純男; 寺崎 哲也; 中島 恵美  日本薬学会年会要旨集  127年会-  (3)  122  -122  2007/03
• Clarification of intracellular localization of CLP36 and ezrin in syncytiotroph oblast and their relevance to polar distribution of transporters in the placenta

  Yoshimichi Sai; Satomi Horieya; Masami Wada; Hisashi Iizasa; Noriko Kose; Emi Nakashima; Tomohiko Wakayama; Atsushi Tamura; Sachiko Tsukita; Kyeong-Eun Lee; Young-Sook Kang  DRUG METABOLISM REVIEWS  38-  63  -64  2006
• Ezrin ノックダウンマウスにおける無酸症の解析 : gastric pareital cell 機能不全について(胃・十二指腸25, 第60回日本消化器外科学会総会)

  菊池 正二郎; 田村 淳; 落合 登志哉; 岡山 徳成; 北川 昌洋; 小西 啓夫; 田儀 知之; 月田 承一郎; 月田 早智子; 山岸 久一  日本消化器外科学会雑誌  38-  (7)  1083  -1083  2005/07
• Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells

  Atsushi Tamura; Shojiro Kitkuchi; Masaki Hata; Tatsuya Katsuno; Tetsuo Noda; Takeshi Matsui; Hisayoshi Hayashi; Yuichi Suzuki; Shoichiro Tsukita; Sachiko Tsukita  CELL STRUCTURE AND FUNCTION  30-  58  -58  2005/06
• Structural conversion between open and closed forms of radixin: Low-angle shadowing electron microscopy

  H Ishikawa; A Tamura; T Matsui; H Sasaki; T Hakoshima; S Tsukita; S Tsukita  MOLECULAR BIOLOGY OF THE CELL  12-  448A  -448A  2001/11

Research Grants & Projects

• グリア系細胞におけるタイトジャンクションの意義と神経病態への関与

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2021/04 -2024/03 

  Author : 佐々木 勉; 田村 淳; 松村 成暢
• Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2019/04 -2024/03 

  Author : 月田 早智子; 田村 淳; Danev Radostin; 後藤 慎平; 田中 啓雄; 中村 駿; 柏原 宏香; 足立 誠; 鈴木 貴; 矢野 智樹; 入江 克雅
• タイトジャンクションは、腫瘍形成を如何にオーガナイズするか？

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2019/04 -2022/03 

  Author : 田村 淳
• Molecular physiology of tight junction Claudin-family based on structural analysis

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016/04 -2019/03 

  Author : Tamura Atsushi
• The role of apical cytoskeletons in transition between centrosomes and ciliary basal bodies.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/06 -2017/03 

  Author : Tsukita Sachiko; YAMAZAKI Yuji; TAMURA Atsushi
• How reciprocal regulation of the cell-cell adhesion and the apical membrane defines a unified epithelial system via the cytoskeleton and cell signaling in epithelial cell sheets

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2016/03 

  Author : Tsukita Sachiko; Yamazaki Yuji; TAMURA Atsushi; Takeuchi Kosei; Mineta Katsuhiko; Ito Masahiko
• The membrane potential and signal transduction of non excitable epithelial cells.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2014/04 -2015/03 

  Author : TAMURA Atsushi
• タイトジャンクションが決める炎症特性とがん

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2013/04 -2015/03 

  Author : 田村 淳
• Electrolytes gradient dependent nutritional absorption.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011 -2013 

  Author : TAMURA Atsushi
• A novel approach to cell adhesion/cytoskeleton research for exploring the epithelia cell system

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2007 -2012 

  Author : TSUKITA Sachiko; MATSUI Takeshi; SASAKI Hiroyuki; TAKEUCHI Kosei; YAMAZAKI Yuji; TAMURA Atsushi
• 細胞接着関連因子による上皮細胞間バリアーの形成とバリアー内イオンチャンネル形成機構

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2008 -2009 

  Author : 月田 早智子; 田村 淳
• 炎症/発癌の下地形成における上皮細胞間バリアー機能不全

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2008 -2009 

  Author : 月田 早智子; 田村 淳
• The analysis of cell-cell barrier function in intestine

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2007 -2009 

  Author : TAMURA Atsushi
• Molecular mechanisms of cell-cell adhesion in cancer cells

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2005 -2009 

  Author : FURUSE Mikio; TSUKITA Sachiko; ADACHI Makoto; KUBO Akiharu; TAMURA Atsushi; ODA Yukako; SASAKI Hiroyuki
• 上皮細胞における膜インターフェイスとしての細胞間接着関連分子群

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2007 -2008 

  Author : 月田 早智子; 田村 淳; 佐々木 博之