Tate Naoko

Researcher Information

Affiliation

Faculty of Pharma-Science Professor
Faculty of Pharma-Science Dean

Degree

• (BLANK)（The University of Tokyo）
• (BLANK)（The University of Tokyo）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901053787876999

J-Global ID

• 200901053787876999

Research Interests

• 神経科学   生化学   構造生物学   生物物理学   Biophysics   Biochemistry   

Research Areas

• Life sciences / Neuroscience - general
• Life sciences / Pharmaceuticals - analytical and physicochemistry
• Life sciences / Biophysics
• Life sciences / Structural biochemistry

Academic & Professional Experience

• 2023/04 - Today  Teikyo UniversityFaculty of Pharma-SciencesProfessor, Dean
• 2013/04 - Today  Teikyo University
• 2004/04 - 2013/03  Musashino University
• 1994 - 1998  Kyorin UniversityFaculty of Medicine

Education

• 1980/04 - 1984/03  The University of Tokyo  Faculty of Pharmaceutical Sciences  Department of Pharmacy

Association Memberships

• 日本生化学会   日本生物物理学会   日本薬学会   日本薬学教育学会   THE CHEMICAL SOCIETY OF JAPAN   日本分子生物学会   D-アミノ酸学会   

Research Activity Information

Published Papers

• Overview of the Impact of Pathogenic LRRK2 Mutations in Perkinson’sDisease.

  Genta Ito; Naoko Utsunomiya-Tate

  Biomolecules 13 845  2023/05 [Refereed]
  
• LRRK2-mediated phosphorylation and thermal stability of Rab12 are regulated by bound nucleotide.

  Genta Ito; Taisuke Tomita; Naoko Utsunomiya-Tate

  Biochemical Biophysical Research Communications 667 43 - 49 2023/05 [Refereed]
  
• Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency.

  Takuya Murata; Genta Ito; Naoko Utsunomiya-Tate

  Biochemical and biophysical research communications 654 18 - 25 2023/04 [Refereed]
  
• A tailored tetravarent peptide displays dual functions to inhibit amyloid β production and aggregation.

  Sato W; Watanabe-Takahashi M; Murata T; Utsunomiya-Tate N; Motoyama J; Anzai M; Ishihara, S; Nishioka N; Uchiyama H; Togashi J; Nishihara S; Kawasaki K; Saito T; Saido T. C; Funamoto S; Nishikawa K

  Communcations Biology 6 383  2023/04 [Refereed]
  
• A dementia-inclusive symbiotic society

  Naoko Utsunomiya-Tate; Genta Ito

  Impact : New frontiers in medical technology 33 - 35 2023/04 [Invited]
  
• Adverse drug event profile associated with anti-dementia drugs: analysis of a spontaneous reportoing database.

  E. Kose; T. Yamamoto; N. Tate; A. ANdo; N. Enomoto; N. Yasuno

  Pharmazie 78 42 - 46 2023 [Refereed]
  
• Physicochemical characterization of G51D mutation of α - sinyuclein that is responsible for its severe cytotoxcocoty

  Murata, T; Tochio N; Utsunomiya-Tate, N

  Neuroscience Lett. 760 136077  2021/06 [Refereed]
  
• The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions

  Takuya Murata, Yuka Unnno, Mitsunori, Fukuda and Naoko Utsunomiya-Tate

  Biochemistry and Biophysics Reports 23 100776  2020/06 [Refereed]
  
• Effect of site-specific amino acid D-isomerization on β-sheet transition and fibril formation profiles of Tau microtuble-binding repeat.

  Utsunomiya-Tate, N

  Biochem. Biophys, Res. Commun. 508 184 - 190 2019/01 [Refereed]
  
• The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation.

  Naoko Utsunomiya-Tate

  FEBS Lett. 592 (18) 3082 - 3091 2018 [Refereed]
  
• A docking model of dapsone bound to HLA-B*13:01 explains the risk of dapsone hypersensitivity syndrome

  Hideaki Watanabe; Yurie Watanabe; Yasuya Tashiro; Taisei Mushiroda; Takeshi Ozeki; Hideo Hashizume; Hirohiko Sueki; Toshinori Yamamoto; Naoko Utsunomiya-Tate; Hiroaki Gouda; Yoshio Kusakabe

  Journal of Dermatological Science Elsevier Ireland Ltd 88 (3) 320 - 329 1873-569X 2017/12 [Refereed]
  
• Phosphorylation of syntaxin-3 at Thr 14 negatively regulates exocytosis in RBL-2H3 mast cells

  Satoshi Tadokoro; Tetsuhiro Shibata; Yoshikazu Inoh; Toshiro Amano; Mamoru Nakanishi; Naohide Hirashima; Naoko Utsunomiya-Tate

  CELL BIOLOGY INTERNATIONAL WILEY 40 (5) 589 - 596 1065-6995 2016/05 [Refereed]
  
• Effect of Complexin II on Membrane Fusion between Liposomes Containing Mast Cell SNARE Proteins

  Satoshi Tadokoro; Naohide Hirashima; Naoko Utsunomiya-Tate

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 39 (3) 446 - 449 0918-6158 2016/03 [Refereed]
  
• Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPlase

  Jing Wang; Naoya Tochio; Ryosuke Kawasaki; Yu Tamari; Ning Xu; Jun-ichi Uewaki; Naoko Utsunomiya-Tate; Shin-ichi Tate

  BIOCHEMISTRY AMER CHEMICAL SOC 54 (33) 5242 - 5253 0006-2960 2015/08 [Refereed]
  
• The C113D Mutation in Human Pin1 Causes Allosteric Structural Changes in the Phosphate Binding Pocket of the PPIase Domain through the Tug of War in the Dual-Histidine Motif

  Ning Xu; Naoya Tochio; Jing Wang; Yu Tamari; Jun-ichi Uewaki; Naoko Utsunomiya-Tate; Kazuhiko Igarashi; Takuma Shiraki; Naohiro Kobayashi; Shin-ichi Tate

  BIOCHEMISTRY AMER CHEMICAL SOC 53 (34) 5568 - 5578 0006-2960 2014/09 [Refereed]
  
• Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-beta

  Toshihiko Sugiki; Naoko Utsunomiya-Tate

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 441 (2) 493 - 498 0006-291X 2013/11 [Refereed]
  
• Preferential domain orientation of HMGB2 determined by the weak intramolecular interactions mediated by the interdomain linker

  Jun-ichi Uewaki; Hironari Kamikubo; Jun-ichi Kurita; Noriteru Hiroguchi; Hiroshi Moriuchi; Michiteru Yoshida; Mikio Kataoka; Naoko Utsunomiya-Tate; Shin-ichi Tate

  CHEMICAL PHYSICS ELSEVIER SCIENCE BV 419 212 - 223 0301-0104 2013/06 [Refereed]
  
• Tetrameric Interaction of the Ectoenzyme CD38 on the Cell Surface Enables Its Catalytic and Raft-Association Activities

  Miki Hara-Yokoyama; Mutsuko Kukimoto-Niino; Kazue Terasawa; Satoru Harumiya; Katarzyna A. Podyma-Inoue; Nobumasa Hino; Kensaku Sakamoto; Satsuki Itoh; Noritaka Hashii; Yoko Hiruta; Nana Kawasaki; Chiemi Mishima-Tsumagari; Yoko Kaitsu; Tomoko Matsumoto; Motoaki Wakiyama; Mikako Shirouzu; Takeshi Kasama; Hiroshi Takayanagi; Naoko Utsunomiya-Tate; Kiyoshi Takatsu; Toshiaki Katada; Yoshio Hirabayashi; Shigeyuki Yokoyama; Masaki Yanagishita

  STRUCTURE CELL PRESS 20 (9) 1585 - 1595 0969-2126 2012/09 [Refereed]
  
• D-Ser-containing humanin shows promotion of fibril formation

  Kanehiro Hayashi; Jumpei Sasabe; Tomohiro Chiba; Sadakazu Aiso; Naoko Utsunomiya-Tate

  AMINO ACIDS SPRINGER 42 (6) 2293 - 2297 0939-4451 2012/06 [Refereed]
  
• Controlled structure and properties of silicate nanoparticle networks for incorporation of biosystem components

  Kumiko Sakai-Kato; Toshiaki Hasegawa; Akio Takaoka; Masaru Kato; Toshimasa Toyo'oka; Naoko Utsunomiya-Tate; Toru Kawanishi

  NANOTECHNOLOGY IOP PUBLISHING LTD 22 (20) 1 - 8 0957-4484 2011/05 [Refereed]
  
• 1P003 Preferential domain orientation of a full length HMGB2 protein and the role of the linker region(Protein:Structure,The 48th Annual Meeting of the Biophysical Society of Japan)

  Uewaki Jun-ichi'; Tate Naoko; Tate Shin-ichi

  Seibutsu Butsuri The Biophysical Society of Japan General Incorporated Association 50 (2) S19  2010
• Collagen racemization and deposition in the lungs of sged rats

  TATE Naoko

  Biochem. Insight 3 25 - 33 2010 [Refereed]
  
• Stability of folding structure of Zic zinc finger proteins

  Kumiko Sakai-Kato; Yoshinori Umezawa; Katsuhiko Mikoshiba; Jun Aruga; Naoko Utsunomiya-Tate

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 384 (3) 362 - 365 0006-291X 2009/07 [Refereed]
  
• 3P-007 D-amino acids are contained in the Alzheimer's disease-related proteins.(Protein:Structure,The 47th Annual Meeting of the Biophysical Society of Japan)

  Kasai Akiko; Tate Naoko

  Seibutsu Butsuri The Biophysical Society of Japan General Incorporated Association 49 S151 - S152 2009
• 2P-016 Preferential domain orientation of a full length HMGB2 protein determined by a novel NMR technique(Protein:Structure,The 47th Annual Meeting of the Biophysical Society of Japan)

  Uewaki Jun-ichi; Moriuchi Hiroshi; Tate Naoko; Tate Shin-ichi

  Seibutsu Butsuri The Biophysical Society of Japan General Incorporated Association 49 S108 - S109 2009
• 3P-052 Analysis of structure stability of HMGB2(Protein:Property,The 47th Annual Meeting of the Biophysical Society of Japan)

  Moriuchi Hiroshi; Tate Shin-ichi; Tate Naoko

  Seibutsu Butsuri The Biophysical Society of Japan General Incorporated Association 49 S159  2009
• Screening system for d-Asp-containing proteins using d-aspartyl endopeptidase and two-dimensional gel electrophoresis

  Kumiko Sakai-Kato; Tadatoshi Kinouchi; Noriko Fujii; Kazuhiro Imai; Naoko Utsunomiya-Tate

  AMINO ACIDS SPRINGER 36 (1) 125 - 129 0939-4451 2009/01 [Refereed]
  
• Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein

  Tatsuhiro Akaishi; Takeo Morimoto; Mami Shibao; Sayaka Watanabe; Kumiko Sakai-Kato; Naoko Utsunomiya-Tate; Kazuho Abe

  NEUROSCIENCE LETTERS ELSEVIER IRELAND LTD 444 (3) 280 - 285 0304-3940 2008/10 [Refereed]
  
• CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA

  Kumiko Sakai-Kato; Akira Ishiguro; Katsuhiko Mikoshiba; Jun Aruga; Naoko Utsunomiya-Tate

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS ELSEVIER SCIENCE BV 1784 (7-8) 1011 - 1019 1570-9639 2008/07 [Refereed]
  
• Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain

  Minoru Hatayama; Tadashi Tomizawa; Kumiko Sakai-Kato; Patrice Bouvagnet; Shingo Kose; Naoko Imamoto; Shigeyuki Yokoyama; Naoko Utsunomiya-Tate; Katsuhiko Mikoshiba; Takanori Kigawa; Jun Aruga

  Human Molecular Genetics 17 (22) 3459 - 3473 0964-6906 2008 [Refereed]
  
• Racemization of the amyloidal beta Asp(1) residue blocks the acceleration of fibril formation caused by racemization of the ASP(23) residue

  Kumiko Sakai-Kato; Megumi Naito; Naoko Utsunomiya-Tate

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 364 (3) 464 - 469 0006-291X 2007/12 [Refereed]
  
• Chimeric structural stabilities in the coiled-coil structure of the NECK domain in human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1)

  Tomoko Ishigaki; Izuru Ohki; Naoko Utsunomiya-Tate; Shin-icih Tate

  JOURNAL OF BIOCHEMISTRY JAPANESE BIOCHEMICAL SOC 141 (6) 855 - 866 0021-924X 2007/06 [Refereed]
  
• Cationic starch derivatives as dynamic coating additives for protein analysis in capillary electrophoresis

  K Sakai-Kato; M Kato; T Nakajima; T Toyo'oka; K Imai; N Utsunomiya-Tate

  JOURNAL OF CHROMATOGRAPHY A ELSEVIER SCIENCE BV 1111 (2) 127 - 132 0021-9673 2006/04 [Refereed]
  
• Creation of a P450 array toward high-throughput analysis

  K Sakai-Kato; M Kato; H Homma; T Toyo'oka; N Utsunomiya-Tate

  ANALYTICAL CHEMISTRY AMER CHEMICAL SOC 77 (21) 7080 - 7083 0003-2700 2005/11 [Refereed]
  
• Molecular-orientation analysis based on alignment-induced TROSY chemical shift changes

  S Tate; H Shimahara; N Utsunomiya-Tate

  JOURNAL OF MAGNETIC RESONANCE ACADEMIC PRESS INC ELSEVIER SCIENCE 171 (2) 284 - 292 1090-7807 2004/12 [Refereed]
  
• Measurement of N-15 chemical shift anisotropy in a protein dissolved in a dilute liquid crystalline medium with the application of magic angle sample spinning

  J Kurita; H Shimahara; N Utsunomiya-Tate; S Tate

  JOURNAL OF MAGNETIC RESONANCE ACADEMIC PRESS INC ELSEVIER SCIENCE 163 (1) 163 - 173 1090-7807 2003/07 [Refereed]
  
• The structure analysis of Zic1 zinc finger region

  TATE Naoko

  Seikagaku 75 859  2003 [Refereed]
  
• Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

  N Utsunomiya-Tate; K Kubo; S Tate; M Kainosho; E Katayama; K Nakajima; K Mikoshiba

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 97 (17) 9729 - 9734 0027-8424 2000/08 [Refereed]
  
• Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

  TATE Naoko

  Soc. Neurisci. Abs 30 25  2000 [Refereed]
  
• Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain

  H Kusuhara; T Sekine; N Utsunomiya-Tate; M Tsuda; R Kojima; SH Cha; Y Sugiyama; Y Kanai; H Endou

  JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 274 (19) 13675 - 13680 0021-9258 1999/05 [Refereed]
  
• Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine

  T Sekine; H Kusuhara; N Utsunomiya-Tate; M Tsuda; Y Sugiyama; Y Kanai; H Endou

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC 251 (2) 586 - 591 0006-291X 1998/10 [Refereed]
  
• C-26 Na^+/グルコーストランスポーターファミリーのヒト腎からのクローニング及び調節因子RS1による機能修飾(一般口演,第26回杏林医学会総会)

  Naoko Utsunomiya-Tate; Yoshikatsu Kanai; Hitoshi Endou

  杏林医学会雑誌 杏林医学会 29 (1) 160 - 161 1998
• Tissue specific variants of glutamate transporter GLT-1

  N UtsunomiyaTate; H Endou; Y Kanai

  FEBS LETTERS ELSEVIER SCIENCE BV 416 (3) 312 - 316 0014-5793 1997/10 [Refereed]
  
• D-6 グルタミン酸トランスポーターの基質結合部位に関する検討(一般口演,第25回杏林医学会総会)

  Naoko Utsunomiya-Tate; Yoshikatsu Kanai; Hitoshi Endou

  杏林医学会雑誌 杏林医学会 28 (1) 126 - 126 1997
• D-8 マウス脳からの神経伝達物質トランスポーター類縁蛋白のcDNAクローニング(一般口演,第25回杏林医学会総会)

  Naoko Utsunomiya-Tate; Yoshikatsu Kanai; Hitoshi Endou

  杏林医学会雑誌 杏林医学会 28 (1) 127 - 127 1997
• A novel Na+-dependent amino acid transporter with a high affinity to glutamine

  H Endou; Y Kanai; N UtsunomiyaTate; M Hosoyamada

  NUTRITIONAL AND ACID-BASE ASPECTS OF AMINO ACID METABOLISM KARGER 121 31 - 36 0302-5144 1997 [Refereed]
  
• Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter

  N UtsunomiyaTate; H Endou; Y Kanai

  JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 271 (25) 14883 - 14890 0021-9258 1996/06 [Refereed]
  
• D-4 テラトカルシノーマ細胞PA-1における中性アミノ酸トランスポーターの発現(一般口演,第24回杏林医学会総会)

  Shugyoku Kin; Naoko Utsunomiya-Tate; Yoshikatsu Kanai; Hitoshi Endou

  杏林医学会雑誌 杏林医学会 27 (1) 133 - 134 1996
• D-3 新規中性アミノ酸トランスポーターSNAT 1のcDNAクローニング(一般口演,第24回杏林医学会総会)

  Naoko Utsunomiya-Tate; Yoshikatsu Kanai; Hitoshi Endou

  杏林医学会雑誌 杏林医学会 27 (1) 133 - 133 1996
• Infrared and Raman spectra of N-chloromethylamine

  K Fukumoto; N UtsunomiyaTate; E Masuko; Y Hamada; AY Hirakawa

  CHEMICAL PHYSICS ELSEVIER SCIENCE BV 202 (2-3) 253 - 262 0301-0104 1996/01 [Refereed]
  
• INFRARED AND RAMAN-SPECTRA OF N-CHLOROETHYLAMINE

  N UTSUNOMIYATATE; K FUKUMOTO; E MASUKO; K KANSAKU; AY HIRAKAWA; Y HAMADA; Y AMATATSU

  CHEMICAL PHYSICS ELSEVIER SCIENCE BV 201 (1) 47 - 58 0301-0104 1995/12 [Refereed]
  
• SOLUTION STRUCTURE OF A HUMAN CYSTATIN-A VARIANT, CYSTATIN-A(2-98) M65L, BY NMR-SPECTROSCOPY - A POSSIBLE ROLE OF THE INTERACTIONS BETWEEN THE N-TERMINI AND C-TERMINI TO MAINTAIN THE INHIBITORY ACTIVE FORM OF CYSTATIN-A

  S TATE; T USHIODA; N UTSUNOMIYATATE; K SHIBUYA; Y OHYAMA; Y NAKANO; H KAJI; F INAGAKI; T SAMEJIMA; M KAINOSHO

  BIOCHEMISTRY AMER CHEMICAL SOC 34 (45) 14637 - 14648 0006-2960 1995/11 [Refereed]
  
• RAPID COREPRESSOR EXCHANGE FROM THE TRP-REPRESSOR/OPERATOR COMPLEX - AN NMR-STUDY OF [UL-C-13/N-15]-L-TRYPTOPHAN

  W LEE; M REVINGTON; NA FARROW; A NAKAMURA; N UTSUNOMIYATATE; Y MIYAKE; M KAINOSHO; CH ARROWSMITH

  JOURNAL OF BIOMOLECULAR NMR ESCOM SCI PUBL BV 5 (4) 367 - 375 0925-2738 1995/06 [Refereed]
  
• D-24 エクソヌクレアーゼIIIデリーション法を用いたマウスグルタミン酸トランスポーターcDNAのシークエンシング(一般口演,第23回杏林医学会総会)

  Ouba Hisako; Naoko Utsunomiya-Tate, N. Yoshikatsu Kanai; Hitoshi Endou

  杏林医学会雑誌 杏林医学会 26 (1) 131 - 131 1995
• Comparison of glutamate transporter GLT-1 mRNAs in brain and peripheral tissue

  TATE Naoko

  Soc. Neurisci. Abs 25 215  1995 [Refereed]
  
• Cloning and characterzation of mouse glial cell glutamate transporter GLT-1

  TATE Naoko

  Jpn. I. Pharmacol. 67 231  1995 [Refereed]
  
• Structure determination of recombinant human cyctatin A using heteronuclear multidimensional NMR spectroscopy

  TATE Naoko

  Int. Magnetic resonance in biol. sysytem 30 364  1994 [Refereed]
  
• Cloning of mouse neuronal and glial high affinity glutamate transporter

  TATE Naoko

  Soc. Neurosci. Abs. 24 925  1994 [Refereed]
  
• Structural of adenylate cyclase activating peptide helodremin bound to micelles determined by 2-D NMR and distance geometry calculation

  TATE Naoko

  Int. Biochem. and Molecular Biol. 1 2  1993 [Refereed]
  
• A NOVEL N-15-LABELING METHOD TO SELECTIVELY OBSERVE (NH2)-N-15 RESONANCES OF PROTEINS IN H-1-DETECTED HETERONUCLEAR CORRELATION SPECTROSCOPY

  S TATE; NU TATE; MW RAVERA; M JAYE; F INAGAKI

  FEBS LETTERS ELSEVIER SCIENCE BV 297 (1-2) 39 - 42 0014-5793 1992/02 [Refereed]
  
• RECOGNITION OF THE SELF IDIOTYPE BY T-CELLS - INDUCTION OF A RAPID INCREASE IN CYTOPLASMIC FREE CALCIUM IN T-CELLS RECOGNIZING A VARIABLE L-CHAIN DETERMINANT

  N UTSUNOMIYA-TATE; M NAKANISHI; Y ARATA; H SUGIYAMA; ME VERAANTOLA; H FUJIO; N SAKATO

  MICROBIOLOGY AND IMMUNOLOGY CENTER ACADEMIC PUBL JAPAN 36 (4) 407 - 418 0385-5600 1992 [Refereed]
  
• ANALYSIS OF THE MOLECULAR REQUIREMENTS FOR T-CELL RECOGNITION AND ACTIVATION BY USING LA-CONTAINING LIPID VESICLES AND STOPPED-FLOW FLUOROMETRY

  C ODAKA; N UTSUNOMIYA; M NAKANISHI; Y ARATA; S MANABE; T YASUDA; T TADAKUMA

  INTERNATIONAL IMMUNOLOGY OXFORD UNIV PRESS UNITED KINGDOM 2 (6) 509 - 514 0953-8178 1990/06 [Refereed]
  
• DIFFERENTIAL SENSITIVITY OF ANTI-IGM-INDUCED AND NAF-INDUCED INOSITOL PHOSPHOLIPID-METABOLISM TO SERINE PROTEASE INHIBITORS IN BAL17 B-LYMPHOMA CELLS

  J MIZUGUCHI; N UTSUNOMIYA; M NAKANISHI; Y ARATA; H FUKAZAWA

  BIOCHEMICAL JOURNAL PORTLAND PRESS 263 (3) 641 - 646 0264-6021 1989/11 [Refereed]
  
• The Research of mechanism of T cell antigen recognition

  TATE Naoko

  University of Tokyo 1989/03 [Refereed]
  
• CELL-MEMBRANE MOLECULE I-J TRANSDUCES A NEGATIVE SIGNAL FOR EARLY T-CELL ACTIVATION INDUCED VIA THE TCR

  Y ASANO; T NAKAYAMA; H KISHIMOTO; T KOMURO; K SANO; N UTSUNOMIYA; M NAKANISHI; T TADA

  IMMUNOLOGICAL RECOGNITION, PTS 1 AND 2 COLD SPRING HARBOR LABORATORY PRESS 54 683 - 688 1989 [Refereed]
  
• CELL-MEMBRANE MOLECULE I-J TRANSDUCES A NEGATIVE SIGNAL FOR EARLY T-CELL ACTIVATION INDUCED VIA THE TCR

  Y ASANO; T NAKAYAMA; H KISHIMOTO; T KOMURO; K SANO; N UTSUNOMIYA; M NAKANISHI; T TADA

  COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY COLD SPRING HARBOR LAB PRESS 54 (2) 683 - 688 0091-7451 1989 [Refereed]
  
• Essential role of trptophan121 of Interleukin2 on the activation of T-lymphocute

  TATE Naoko

  J. Pharmacobio-Dyn 10 132  1989 [Refereed]
  
• T-CELL-MEDIATED RECOGNITION OF FOREIGN ANTIGEN AND THE IA MOLECULE OBSERVED BY STOPPED-FLOW FLUOROMETRY

  N UTSUNOMIYA; M NAKANISHI; Y ARATA; T YASUDA; S SAITO; K KOYAMA; T TADAKUMA

  JOURNAL OF IMMUNOLOGY AMER ASSOC IMMUNOLOGISTS 141 (5) 1471 - 1475 0022-1767 1988/09 [Refereed]
  
• Phorbol myristate acetate inhibits increases in membrane fluidity induced by anti-IgM in B cells

  J. Mizuguchi; N. Utsunomiya; M. Nakanishi; Y. Arata

  Journal of Immunology 140 (8) 2495 - 2499 0022-1767 1988 [Refereed]
  
• EXPRESSION OF CHIMERIC RECEPTOR COMPOSED OF IMMUNOGLOBULIN-DERIVED V-RESIONS AND T-CELL RECEPTOR-DERIVED C-REGIONS

  Y KUWANA; Y ASAKURA; N UTSUNOMIYA; M NAKANISHI; Y ARATA; S ITOH; F NAGASE; Y KUROSAWA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS 149 (3) 960 - 968 0006-291X 1987/12 [Refereed]
  
• EARLY TRANSMEMBRANE EVENTS IN TUMOR-NECROSIS-FACTOR AND LYMPHOTOXIN-INDUCED CYTOTOXICITY

  Y KOBAYASHI; N UTSUNOMIYA; M NAKANISHI; T OSAWA

  IMMUNOLOGY LETTERS ELSEVIER SCIENCE BV 15 (1) 53 - 57 0165-2478 1987/05 [Refereed]
  
• Expression of chimeric receptor composed of immunoglobulin-derived V regions and receptor-derived C region

  TATE Naoko

  Biochem.Biophys.Res. Commun. 149 969 - 974 1987 [Refereed]
  
• A SERINE PROTEASE TRIGGERS THE INITIAL STEP OF TRANSMEMBRANE SIGNALING IN CYTOTOXIC T-CELLS

  N UTSUNOMIYA; M NAKANISHI

  JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 261 (35) 6514 - 6517 0021-9258 1986/12 [Refereed]
  
• INITIAL PROCESSES OF CYTOTOXIC LYMPHOCYTE-T RESPONSES TO TARGET TUMOR-CELLS

  N UTSUNOMIYA; M TSUBOI; M NAKANISHI

  JOURNAL OF PHARMACOBIO-DYNAMICS PHARMACEUTICAL SOC JAPAN 9 (9) S125 - S125 0386-846X 1986/09 [Refereed]
  
• INTERLEUKIN-2 INCREASES LYMPHOCYTE-T MEMBRANE MOBILITY BEFORE THE RISE IN CYTOSOLIC CALCIUM-CONCENTRATION

  N UTSUNOMIYA; M TSUBOI; M NAKANISHI

  BIOCHEMISTRY AMER CHEMICAL SOC 25 (9) 2582 - 2584 0006-2960 1986/05 [Refereed]
  
• ATTENUATION OF THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS BY CHRONIC ORAL-ADMINISTRATION OF EICOSAPENTAENOIC ACID

  Y KASUYA; N UTSUNOMIYA; N MATSUKI

  JOURNAL OF PHARMACOBIO-DYNAMICS PHARMACEUTICAL SOC JAPAN 9 (3) 239 - 243 0386-846X 1986/03 [Refereed]
  
• ATTENUATION OF THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS BY CHRONIC ORAL-ADMINISTRATION OF EICOSAPENTAENOIC ACID

  Y KASUYA; N UTSUNOMIYA; N MATSUKI

  JOURNAL OF PHARMACOBIO-DYNAMICS PHARMACEUTICAL SOC JAPAN 9 (3) 239 - 243 0386-846X 1986/03 [Refereed]
  
• Early transmenbrane events in tumour cell responses observed by stopped-flow fluorometry

  Naoko Utsunomiya

  Proc. Natl. Acad. Sci. USA 83 1877 - 1880 1986 [Refereed]
  
• IL2 increses T lymphocyte membrane mobility before the rise in cytotoxic T cells

  TATE Naoko

  Biochemistry 25 250 - 254 1986 [Refereed]
  
• Early transmembrane events in tumour cell responses observed by stopped-flow fluorometry

  TATE Naoko

  Proc. Natl. Acad. Sci. USA 83 1877 - 1880 1986 [Refereed]
  
• EARLY TRANSMEMBRANE EVENTS IN TUMOR-CELL RESPONSES OBSERVED BY STOPPED-FLOW FLUOROMETRY

  N UTSUNOMIYA; M TSUBOI; M NAKANISHI

  FEBS LETTERS ELSEVIER SCIENCE BV 187 (2) 245 - 248 0014-5793 1985 [Refereed]
  

Books etc

• 医療コミュニケーション 第2版

  楯 直子 (Editor全般)京都廣川書店 2022/03
• 薬学生の物理化学

  楯, 直子; 平嶋, 尚英(共編) 培風館 2021/09 9784563085681 vi, 269p
• 薬学生を対象としたメンタルヘルスファーストエイド教育の導入とその評価

  斎藤百枝美、村上勇、中村英里、安藤嵩仁、土屋雅勇、楯 直子、栗原順一 日本薬学教育学会 2018/10
• 医療コミュニケーション

  楯 直子 (Editor全般)京都廣川書店 2018/07
• 患者中心の医療を実現するためのコミュニケーション教育

  楯 直子 (Joint workMIL (Mission in Life) 65号：P7.~P.11)エニイクリエイティブ 2015/10
• 帝京大学医療系全学部の初年次におけるコミュニケーション教育

  楯 直子 日本ヘルスコミュニケーション学会雑誌(2015) 6, 68-78 2015
• 薬学生のための基礎シリーズ7 基礎化学

  楯 直子 (Joint editor全般)培風館 2014
• アミロイドβペプチドの凝集に及ぼすD-アスパラギン酸の影響

  楯 直子 (Joint work京都大学原子炉研究所レポート)2010
• 講義室「恩師 坪井正道先生」

  楯 直子 (Single work日本薬学会 44巻 P,224)日本薬学会 ファルマシア 44巻 P.224 2008
• 医薬品の陰の立役者「物理化学」を学ぶ

  楯 直子 (Single workリクルート進学ネット)リクルート進学ネット リクルート 2008
• 薬学教育支援システム：専門教材：コアカリキュラム教材

  楯 直子 (Single workコンピュータソフト)アルプ社 2006
• Encapusulated biomolecules using sol-gel reaction for high-throughput screening

  TATE Naoko (Joint workFrontiers in Drug Design and Discovery 3, 279-293)2006
• 化学平衡

  楯 直子 (Joint work日本薬学会編 物理系薬学Ⅱ 化学物質の分析)東京化学同人 2005
• 研究手法の原理と具体的方法：cDNAクローニングにより遺伝子が得られたら何を調べるか―変異導入

  楯 直子 (Single work腎と透析 45巻増刊 P.106-110)東京医学社 1998
• シナプス―構造と機能；トランスポーター作用薬

  楯 直子 (Joint work臨床神経科学 14巻、P.936-937)中外医学社 1996
• 糖―その多様性を探る―2次元NMRによる解析

  楯 直子 (Joint workP.133-142)化学同人 1992
• 蛍光スップト・フロー法

  楯 直子 (Joint work)化学同人 1989

MISC

• Flavonoids inhibit or promote formation of amyloid beta fibrils in vitro

  Tatsuhiro Akaishi; Takeo Morimoto; Mami Shibao; Kumiko Sakai-Kato; Naoko Tate; Kazuho Abe  JOURNAL OF PHARMACOLOGICAL SCIENCES  106-  184P  -184P  2008
• D-Aspartyl Endopeptidaseを利用したD-アスパラギン酸含有タンパク質の網羅的スクリーニング法の開発

  加藤(酒井)くみ子; 木野内忠稔; 藤井紀子; 今井洋一; 楯直子  第4回D-アミノ酸研究会学術講演会  2008
• 3P035 The conformational and physicochemical characteristics of Zic proteins(Proteins-structure and structure-function relationship,Poster Presentations)

  Sakai-Kato Kumiko; Kasai Akiko; Ishiguro AKira; Mikoshiba Katsuhiko; Aruga Jun; Utsunomiya-Tate Naoko  Seibutsu Butsuri  47-  (0)  S211  2007
• 3P036 A structural dynamics of Zic family proteins, C2H2-type zinc finger proteins, and their relationships with Gli/Glis family proteins(Proteins-structure and structure-function relationship,Poster Presentations)

  Sakai-Kato Kumiko; Ishiguro Akira; Aruga Jun; Utsunomiya-Tate Naoko  Seibutsu Butsuri  47-  (0)  S212  2007
• Encapsulated biomolecules using sol-gel reaction for high-throughput screening

  Kumik Sakai-Kato; Masaru Kato; Naoko Utsunomiya-Tate; Toshimasa Toyo'oka  Frontiers in Drug Design and Discovery  2-  (1)  273  -294  2006/03
• Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

  N Utsunomiya-Tate; K Kubo; S Tate; M Kainosho; E Katayama; K Nakajima; K Mikoshiba  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  97-  (17)  9729  -9734  2000/08
• Tissue specific variants of glutamate transporter GLT-1

  N UtsunomiyaTate; H Endou; Y Kanai  FEBS LETTERS  416-  (3)  312  -316  1997/10
• Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter

  N UtsunomiyaTate; H Endou; Y Kanai  JOURNAL OF BIOLOGICAL CHEMISTRY  271-  (25)  14883  -14890  1996/06
• Infrared and Raman spectra of N-chloroethylamine

  Naoko Utsunomiya-Tate; Kikuko Fukumoto; Ei-ichi Masuko; Koji Kansaku; Akiko Y. Hirakawa; Yoshiaki Hamada; Yoshiaki Amatatsu  Chemical Physics  201-  (1)  47  -58  1995/12
• D-28 神経細胞型およびグリア細胞型グルタミン酸トランスポーターのマウス脳からのcDNAクローニング(一般口演,第23回杏林医学会総会)

  楯 直子; 細山田 真; 菅野 賢吉; 大羽 尚子; 金井 好克; 遠藤 仁  杏林医学会雑誌  26-  (1)  133  -133  1995/03
• Structural Analysis of cystatin A with NMR.

  NAKANO YASUHIRO; USHIODA TOSHIO; TATE SHIN'ICHI; TATE NAOKO; KAJI HIROYUKI; INAGAKI FUYUHIKO; SAMEJIMA TATSUYA; KAINOSHO MASATSUNE  日本生物物理学会年会講演予稿集  32nd-  S148  1994/09
• RECOGNITION OF THE SELF IDIOTYPE BY T-CELLS - INDUCTION OF A RAPID INCREASE IN CYTOPLASMIC FREE CALCIUM IN T-CELLS RECOGNIZING A VARIABLE L-CHAIN DETERMINANT

  N UTSUNOMIYATATE; M NAKANISHI; Y ARATA; H SUGIYAMA; ME VERAANTOLA; H FUJIO; N SAKATO  MICROBIOLOGY AND IMMUNOLOGY  36-  (4)  407  -418  1992
• Unidirectional inhibition of early signal transduction of helper T cells by cloned suppressor T cells

  Naoko Utsunomiya; Mamoru Nakanishi; Yoji Arata; Masato Kubo; Yoshlhiro Asano; Tomio Tada  International Immunology  1-  (4)  460  -463  1989/09
• T-CELL-MEDIATED RECOGNITION OF FOREIGN ANTIGEN AND THE IA MOLECULE OBSERVED BY STOPPED-FLOW FLUOROMETRY

  N UTSUNOMIYA; M NAKANISHI; Y ARATA; T YASUDA; S SAITO; K KOYAMA; T TADAKUMA  JOURNAL OF IMMUNOLOGY  141-  (5)  1471  -1475  1988/09
• A SERINE PROTEASE TRIGGERS THE INITIAL STEP OF TRANSMEMBRANE SIGNALING IN CYTOTOXIC T-CELLS

  N UTSUNOMIYA; M NAKANISHI  JOURNAL OF BIOLOGICAL CHEMISTRY  261-  (35)  6514  -6517  1986/12
• EARLY TRANSMEMBRANE EVENTS IN ALLOIMMUNE CYTOTOXIC LYMPHOCYTE-T ACTIVATION AS REVEALED BY STOPPED-FLOW FLUOROMETRY

  N UTSUNOMIYA; M TSUBOI; M NAKANISHI  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  83-  (6)  1877  -1886  1986/03

Research Grants & Projects

• 認知症との共生社会構築

  帝京大学先端総合研究機構：チーム研究

  Date (from‐to) : 2021/04 -2026/03 

  Author : 代表:楯 直子; 林 俊宏; 磯尾紀子; 伊藤弦太; 村田拓哉; 安野伸浩; 斉藤史明; 渡邊清高; 上野公子他
• The analysis of the pathogenic effect by aging of amyloid β peptide

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2021/04 -2024/03 

  Author : 楯 直子
• 病原性タンパク質タウの生物物理学的特性に基づくアルツハイマー病進展メカニズムの解明

  帝京大学先端総合研究機構：連携研究

  Date (from‐to) : 2020/04 -2021/03 

  Author : 代表:楯 直子; 林 俊宏; 磯尾紀子; 村田拓哉
• タンパク質の構造解析のための大量培養・精製システムの確立

  文部科学省：研究用備申請（私学助成）私立大学等研究施設等設備費

  Date (from‐to) : 2016/04 

  Author : 楯 直子
• 気道上皮細胞修復をターゲットとした高齢者難治性喘息の治療法の探索

  日本学術振興会：科学研究費 基盤研究（C）

  Date (from‐to) : 2010/04 -2012/03
• D-アミノ酸により誘導されるアミロイド凝集機構の抗アルツハイマー病薬の開発

  文部科学省：科学研究費 基盤研究(C)

  Date (from‐to) : 2009/04 -2011/03 

  Author : 楯 直子
• 老年性疾患に関する分子基盤研究と治療法に関する研究

  文部科学省：ハイテクリサーチセンター整備事業

  Date (from‐to) : 2004/04 -2008/03 

  Author : 今井 一洋、楯 直子
• 生体内に存在する異性化D-アミノ酸含有蛋白質と関連疾患に関する研究

  科学研究費補助金

  Date (from‐to) : 2004
• 脳内の神経細胞位置決定分子リーリンの会合体形成機構の解明と神経疾患の治療への応用

  文部科学省：科学研究費 基盤研究(C)

  Date (from‐to) : 2001/04 -2003/03 

  Author : 楯 直子
• 腎特異性有機陰イオン薬物トランスポーターの遺伝子クローニングと機能発現

  文部科学省：科学研究費 基盤研究(B)

  Date (from‐to) : 1997/04 -1999/03 

  Author : 遠藤 仁; 楯 直子
• グルタミン酸トランスポーターファミリーの基質透過とチャネル形成の分子機構

  文部省：科学研究費 重点領域研究

  Date (from‐to) : 1997/04 -1998/03 

  Author : 金井 好克、楯 直子
• 神経細胞保護因子としてのアミノ酸トランスポーターの病態学的及び薬理学的意義の検討

  文部省：科学研究費 国際学術研究

  Date (from‐to) : 1997/04 -1998/03 

  Author : 金井好克; 楯 直子
• T細胞機能の酸化還元的制御に関わるアミノ酸トランスポーターの同定

  文部省：奨励研究(A)

  Date (from‐to) : 1997/04 -1998/03 

  Author : 楯 直子
• グルタミン酸トランスポーターファミリーの構造機能相関の解析

  文部省：科学研究費 重点領域研究

  Date (from‐to) : 1996/04 -1997/03 

  Author : 金井 好克; 楯 直子
• 腫瘍細胞アミノ酸トランスポーターのクローニング及びその薬物感受性に検討

  文部省：科学研究費 奨励研究(A)

  Date (from‐to) : 1996/04 -1997/03 

  Author : 楯 直子
• シスチン・グルタミン酸交換輸送体の分子的実体―酸化的ストレスからの細胞保護因子

  文部省：科学研究費 基盤研究(C)

  Date (from‐to) : 1995/04 -1997/03 

  Author : 金井好克; 楯 直子
• 神経系におけるグルタミン酸トランスポーターの機能的役割の解明

  文部省：科学研究費 国際学術研究

  Date (from‐to) : 1995/04 -1996/03 

  Author : 金井好克; 楯 直子
• 新規制がん物質の単離、精製と作用機構の解明

  公益信託 林女性自然科学者研究助成基金：研究補助金

  Date (from‐to) : 1990/04 -1992/03 

  Author : 楯 直子
• ストップト・フロー法による免疫応答機構の解析

  文部省：科学研究費 奨励研究(A)

  Date (from‐to) : 1988/04 -1989/03 

  Author : 楯(宇都宮) 直子
• 脳・神経系の機能蛋白質および病因蛋白質に関する構造生物学的研究

  科学研究費補助金
• Biostructural Study on Functional Protein of Brain

  Grant-in-Aid for Scientific Research

  Author : Naoko Utsunomiya-Tate