Yoshioka Noboru

Researcher Information

Affiliation

General Medical Education and Research Center (G-MEC) Associate Professor

Degree

• PhD.（Univ. Tokyo）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901090025668631

J-Global ID

• 200901090025668631

Profile

• 所属: 帝京大学医学部生理学講座

Research Interests

• Cell Therapy   Regeneration of Nervous System   

Research Areas

• Life sciences / Clinical pharmacy / Regeneration of Nervous System
• Life sciences / Physiology / Regeneration of Nervous System

Academic & Professional Experience

• 2015 - Today  Teikyo Univ. Sch. Med.Dept. Physiol.Lecturer
• 2003/04 - 2015/03  Teikyo Univ. Sch. Med.Dept. Physiol.Lecturer
• 2003 - 2015  Teikyo UniversitySchool of Medicine
• 1990 - 2002  Researching Staff, Teijin Institute for Biomedical Research

Association Memberships

• 北米神経科学会   日本神経科学会   日本生理学会   

Research Activity Information

Published Papers

• Live imaging of neuronal developmental processes using fluorescent protein

  Noboru Yoshioka; Masaki Sakurai

  Histocytochemistry 40 (1) 169 - 175 2015/07 [Invited]
  
• Corticospinal tract development and spinal cord innervation differ between cervical and lumbar cord

  Kamiyama T; Kameda H; Murabe N; Fukuda S; Yoshioka N; Mizukami H; Ozawa K; Sakurai M

  Journal of Neuroscience 35 (3) 1181 - 1191 2015/01 [Refereed]
  
• Axonal Regression in Corticospinal Slice Coculture

  YOSHIOKA Noboru

  The Brain & Neural Network Japanese Neural Network Society 20 (1) 19 - 22 1340-766X 2013/03
• Specific involvement of postsynaptic GluN2B-containing NMDA receptors in the developmental elimination of corticospinal synapses.

  Ohno T; Maeda H; Murabe N; Kamiyama T; Yoshioka N; Mishina M; Sakurai M

  PNASS (Proceedings of the National Academy of Sciences of the United States of America) 34 107 15252 - 15257 0027-8424 2010/08 [Refereed]
  
• Regressive Events in Rat Corticospinal Axons During Development in In Vitro Slice Cocultures: Retraction, Amputation, and Degeneration

  Noboru Yoshioka; Naoyuki Murabe; Masaki Sakurai

  JOURNAL OF COMPARATIVE NEUROLOGY 513 (2) 164 - 172 0021-9967 2009/03 [Refereed]
  
• Synapse elimination in the corticospinal projection during the early postnatal period.

  Kamiyama T; Yoshioka N; Sakurai M

  Journal of Neurophysiology 4 95 2304 - 2313 0022-3077 2006/04 [Refereed]
  
• AXONS REGENERATE WITH CORRECT SPECIFICITY IN HORIZONTAL SLICE CULTURE OF THE POSTNATAL RAT ENTORHINO-HIPPOCAMPAL SYSTEM

  D LI; PM FIELD; N YOSHIOKA; G RAISMAN

  EUROPEAN JOURNAL OF NEUROSCIENCE 6 (6) 1026 - 1037 0953-816X 1994/06 [Refereed]
  
• Alzheimer 型痴呆：APPとその異常分解産物

  吉岡 昇; 森 啓

  内科（南江堂） 70 280  1992

Conference Activities & Talks

• Slow, stable, and long-distance retrograde movement of synaptophysin-positive puncta along axons in corticospinal slice coculture

  N. YOSHIOKA; N. ISOO; N. MURABE; H. KAMEDA; I. TAKAHASHI; M. SAKURAI

  Society for Neuroscience  2013/11
• Morphological study on dendritic arborization pattern of motoneurons: Diversity among pools innervating different types of muscles

  S. FUKUDA; H. MAEDA; N. YOSHIOKA; N. MURABE; H. KAMEDA; M. SAKURAI

  Society for Neuroscience  2013/11

MISC

• Developmental shift of NMDA receptor subunits is essential for closing the critical period in corticospinal synapse elimination

  Takae Ohno; Mutsumi Isowaki; Noriko Isoo; Naoyuki Murabe; Hitoshi Maeda; Satoshi Fukuda; Noboru Yoshioka; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E232  -E232  2011
• Dynamics of presynaptic structures and axons in the development of corticospinal innervation in vitro: Analysis by live imaging

  Noriko Isoo; Takae Ohno; Naoyuki Murabe; Noboru Yoshioka; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E334  -E334  2011
• Long-distance retrograde movement and stabilization of synaptophysin-positive puncta along corticospinal axons during the first postnatal week in slice culture

  Noboru Yoshioka; Tomoki Miyazaki; Noriko Isoo; Naoyuki Murabe; Koji Kameda; Ichiro Takahashi; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E119  -E119  2011
• Differential effect of GluN2B KO vs. GluN2A KO in corticospinal synapse elimination during development: Difference in the amount of Ca2+ entry or its downstream signaling mechanism?

  Takae Ohno; Hitoshi Maeda; Naoyuki Murabe; Tsutomu Kamiyama; Noboru Yoshioka; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  68-  E86  -E87  2010
• GluR epsilon 2 (NR2B) is specifically involved in the corticospinal synapse elimination during development

  Takae Ohno; Hitoshi Maeda; Naoyuki Murabe; Tsutomu Kamiyama; Noboru Yoshioka; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  65-  S37  -S37  2009
• Retrograde movement of synaptophysin-positive puncta along corticospinal axons during development

  Noboru Yoshioka; Naoyuki Murabe; Masaki Sakurai  NEUROSCIENCE RESEARCH  65-  S37  -S37  2009
• Quantitative analysis of axonal regressions during development in the rat corticospinal slice coculture

  Noboru Yoshioka; Naoyuki Muralbe; Masaki Sakurai  NEUROSCIENCE RESEARCH  61-  S56  -S56  2008
• GluR epsilon 2[28] dependent synapse elimination of corticospinal tract in mice

  Takae Ohno; Noboru Yoshioka; Hitoshi Maeda; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  58-  S50  -S50  2007
• Axonal regressive events in rat corticospinal slice coculture studied with time-lapse confocal imaging of single axons

  Noboru Yoshioka; Takae Ohno; Masaki Sakurai  NEUROSCIENCE RESEARCH  58-  S144  -S144  2007
• Time-lapse imaging of in vitro development of corticospinal axons in slice coculture

  Noboru Yoshioka; Masaki Sakurai  NEUROSCIENCE RESEARCH  55-  S61  -S61  2006
• Post-sqnaptic depolarization in indaction of long-term potentiation in the CAI hipocampus

  Neuroreport  6-  (2)  333  1995
• AXONS REGENERATE WITH CORRECT SPECIFICITY IN HORIZONTAL SLICE CULTURE OF THE POSTNATAL RAT ENTORHINO-HIPPOCAMPAL SYSTEM

  D LI; PM FIELD; N YOSHIOKA; G RAISMAN  EUROPEAN JOURNAL OF NEUROSCIENCE  6-  (6)  1026  -1037  1994/06

Industrial Property Rights

• 特願WO/2001/010433:NEUROPATHY IMPROVERS CONTAINING NITROGENOUS COMPOUNDS AS THE ACTIVE INGREDIENT  
• 特願WO/2003/070730:PYRROLOPYRIMIDINE DERIVATIVE  

Research Grants & Projects

• 脊髄損傷モデル系を用いた嗅神経鞘細胞を含む移植用生体材料の調製法最適化

  Kakenhi：Kakenhi

  Date (from‐to) : 2018/04 -2022/03 

  Author : YOSHIOKA Noboru
• 皮質脊髄路シナプスの形成・可塑性・臨界期とそのメカニズム

  Kakenhi：Kakenhi

  Date (from‐to) : 2011/04 -2014/03
• 皮質脊髄シナプスの生後発達、内嗅野海馬シナプスの生後発達

  総合研究

  Date (from‐to) : 2010 -2012
• 皮質脊髄路シナプスの形成と可塑性:臨界期・シナプス競合・多段階発達

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2005 -2005 

  Author : 桜井 正樹; 吉岡 昇; 前田 仁士
• Synapse formation, development and plasticity of corticspinal synapse : An in vitro slice culture study

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2003 -2004 

  Author : SAKURAI Masaki; YOSHIOKA Noboru; MAEDA Hitoshi
• 皮質脊髄路シナプス形成とその可塑性:活動依存性・臨界期・シナプス競合

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2003 -2003 

  Author : 桜井 正樹; 前田 仁士; 吉岡 昇
• 皮質脊髄路発達

  科学研究費補助金

  Date (from‐to) : 2003
• 皮質脊髄投射

  Date (from‐to) : 2003