Tabata Hidestugu

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Associate Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201401086579479833

J-Global ID

• 201401086579479833

Research Interests

• 軸不斉   ビアリール骨格   動的キラリティー   カップリング反応   アトロプ異性体   キラリティー   γ-セクレターゼ阻害薬   ベンゾラクタム   LY-411575   アルツハイマー病治療薬   立体配座異性体   バソプレッシン受容体拮抗薬   ACAT阻害薬   1,4-ベンゾジアゼピン   ジベンゾアゼピン骨格   立体化学   ジベンゾジアゼピノン   ジベンゾアゼピノン   

Research Areas

• Life sciences / Pharmaceuticals - chemistry and drug development

Academic & Professional Experience

• 2019/04 - Today  Teikyo UniversityFaculty of Pharma SciencesAssociate professor
• 2015/04 - 2018/03  Teikyo Unibversitylector
• 2012/10 - 2015/03  Teikyo UniversityFaculty of Pharma-Science
• 2006/10 - 2012/09  Teikyo UniversityFaculty of Pharma-Science

Education

• 2001/04 - 2003/03  Teikyo University
•        -   Teikyo University  School of Pharmaceutical Sciences

Association Memberships

• THE PHARMACEUTICAL SOCIETY OF JAPAN   THE PHARMACEUTICAL SOCIETY OF JAPAN Division of Medicinal Chemistry   THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN   

Research Activity Information

Published Papers

• Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones

  Arisa Chiba; Ryoko Tanaka; Mayuno Hotta; Kayo Nakamura; Kosho Makino; Hidetsugu Tabata; Tetsuta Oshitari; Hideaki Natsugari; Hideyo Takahashi

  Molecules MDPI AG 28 (12) 4734 - 4734 2023/06
• Stereochemical Analysis of Trifluoroacetamide Derivatives Based on Through-Space ¹H–¹⁹F Spin–Spin Couplings

  Yan Li; Chinatsu Ohtake; Mayuno Hotta; Hidetsugu Tabata; Kiriko Hirano; Motoo Iida; Kayo Nakamura; Kosho Makino; Tetsuta Oshitari; Hideaki Natsugari; Takenori Kusumi; Hideyo Takahashi

  The Journal of Organic Chemistry American Chemical Society (ACS) 88 (11) 7026 - 7037 0022-3263 2023/05 [Refereed]
  
• Conversion of Racemic Alkyl Aryl Sulfoxides into Pure Enantiomers Using a Recycle Photoreactor: Tandem Use of Chromatography on Chiral Support and Photoracemization on Solid Support

  Kumi Tozawa; Kosho Makino; Yuki Tanaka; Kayo Nakamura; Akiko Inagaki; Hidetsugu Tabata; Tetsuta Oshitari; Hideaki Natsugari; Noritaka Kuroda; Kunio Kanemaru; Yuji Oda; Hideyo Takahashi

  The Journal of Organic Chemistry American Chemical Society (ACS) 0022-3263 2023/05 [Refereed]
  
• Atropodiastereoselective 5N-Acylation of 1,5-Benzodiazepin-2-ones with (S)-2-Phenylpropanoyl and (S)-2-Phenylbutanoyl Chlorides

  Kaoru Funaki; Hidetsugu Tabata; Yusuke Nakazato; Yuka Takahashi; Tomohiko Tasaka; Hideyo Takahashi; Hideaki Natsugari; Tetsuta Oshitari

  Journal of Organic Chemistry 87 (22) 15289 - 15300 2022/11 [Refereed]
  
• Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood–Brain Barrier

  Toshiki Kurosawa; Yuma Tega; Yasuo Uchida; Kei Higuchi; Hidetsugu Tabata; Takaaki Sumiyoshi; Yoshiyuki Kubo; Tetsuya Terasaki; Yoshiharu Deguchi

  Pharmaceutics 14 (8) 1683 - 1683 2022/08 [Refereed]
  
• Atropisomeric Properties of N-Alkyl/Aryl 5H-Dibenz[b,f]azepines

  Ryoko Tanaka; Ayana Nabae; Koki Yamane; Kosho Makino; Hidetsugu Tabata; Tetsuta Oshitari; Hideaki Natsugari; Hideyo Takahashi

  Chemical and Pharmaceutical Bulletin Pharmaceutical Society of Japan 70 (8) 573 - 579 0009-2363 2022/08 [Refereed]
  
• Axial chirality and affinity at the GABAA receptor of triazolobenzodiazepines

  Tanaka, R; Makino, K; Tabata, H; Oshitari, T; Natsugari, H; Takahashi

  Bioorganic & Medicinal Chemistry 64 (15) 116758  2022/04 [Refereed]
  
• Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B2 Catalyst Under Visible Light Irradiation

  Suga, M; Makino, K; Tabata, H; Oshitari, T; Natsugari, H; Takahashi, H

  Pharmaceutical Research Springer Science and Business Media LLC 39 (3) 577 - 586 0724-8741 2022/03 [Refereed]
  
• Rapid Photoracemization of Chiral Alkyl Aryl Sulfoxides

  Makino, K; Tozawa, K; Tanaka, Y; Inagaki, A; Tabata, H; Oshitari, T; Natsugari, H; Takahashi, H

  Journal of Organic Chemistry 86 17249 - 17256 2021/10 [Refereed]
  
• Atropisomeric Properties of 9-Methyl-1,4-benzodiazepin-2-ones.

  Tanaka, R; Makino, K; Tabata, H; Oshitari, T; Natsugari, H; Takahashi, H

  Synthesis 53 2021/08 [Refereed]
  
• Atropisomeric Properties of N-Acyl/N-Sulfonyl 5H-Dibenzo[b,d]azepin-7(6H)-ones.

  Namba, T; Hotta, M; Tabata, H; Makino, K; Oshitari, T; Natsugari, H; Takahashi, H

  Journal of Organic Chemistry 86 7563 - 7578 2021/05 [Refereed]
  
• Conformational Preference of 2'-Fluoro-Substituted Acetophenone Derivatives Revealed by Through-Space 1H-19F and 13C-19F Spin-Spin Couplings.

  Otake, C; Namba, T; Tabata, H; Makino, K; Hirano, K; Oshitari, T; Natsugari, H; Kusumi, T; Takahashi, H

  Journal of Organic Chemistry American Chemical Society (ACS) 86 (6) 4638 - 4645 0022-3263 2021/03 [Refereed]
  
• Differentiation of Positional Isomers of Halogenated Benzoylindole Synthetic Cannabinoid Derivatives in Serum by Hybrid Quadrupole/Orbitrap Mass Spectrometry.

  Tomoko Fukuuchi; Shun-Suke Moriya; Toru Sugiyama; Hidetsugu Tabata; Kiyoko Kaneko

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 37 (2) 329 - 335 2020/09
• Structural Requirements for Uptake of Diphenhydramine Analogs into hCMEC​/D3 Cells Via the Proton-​Coupled Organic Cation Antiporter

  Tega, Yuma; Tabata, Hidetsugu; Kurosawa, Toshiki; Kitamura, Atsushi; Itagaki, Fumio; Oshitari, Tetsuta; Deguchi, Yoshiharu

  Journal of Pharmaceutical Sciences 2020/09 [Refereed]
  
• Conformational properties and M1 antimuscarinic activity of 4-​substituted pirenzepine​/telenzepine analogues

  Kanase, Yuki; Makino, Kosho; Yoshinaga, Takashi; Tabata, Hidetsugu; Oshitari, Tetsuta; Natsugari, Hideaki; Takahashi, Hideyo

  Heterocycles 101 (1) 273 - 283 2020/07 [Refereed]
  
• Chemoselective Demethylation of Methoxypyridine

  Makino, Kosho; Hasegawa, Yumi; Inoue, Takahide; Araki, Koji; Tabata, Hidetsugu; Oshitari, Tetsuta; Ito, Kiyomi; Natsugari, Hideaki; Takahashi, Hideyo

  Synlett Georg Thieme Verlag KG 30 (8) 951 - 954 0936-5214 2019 [Refereed]
  
• Atropisomeric and Conformational Properties of 6N-Benzoyl- and 6N-p-Tosyl-1,6-Benzodiazocines: Comparison with Those of 1,5-Benzodiazepines

  Tabata, Hidetsugu; Murai, Kazuya; Funaki, Kaoru; Takemae, Chihiro; Tasaka, Tomohiko; Oshitari, Tetsuta; Takahashi, Hideyo; Natsugari, Hideaki

  Heterocycles 99 (1) 566 - 581 2019 [Refereed]
  
• Elucidation of the Active Conformation of Antiproliferative Sulfonamides, 5N‑Arylsulfonyl-1,5-benzodiazepin-2-ones

  Hidetsugu Tabata; Kaoru Funaki; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  Journal of Organic Chemistry 84 16338 - 16345 2019 [Refereed]
  
• 4-Substituted carbamazepine derivatives: Conformational analysis and sodium channel-blocking properties

  Yuki Kanase; Takafumi Kitada; Hidetsugu Tabata; Kosho Makino; Tetsuta Oshitari; Hiromi Ohashi; Takashi Yoshinaga; Hideaki Natsugari; Hideyo Takahashi

  Bioorganic and Medicinal Chemistry Elsevier Ltd 26 (9) 2508 - 2513 1464-3391 2018/05 [Refereed]
  
• SYNTHESIS OF 3-AROYLINDOLES AS INTERMEDIATES OF CANNABIMIMETICS AND ELUCIDATION OF THEIR PHYSICOCHEMICAL PROPERTIES

  Araki Koji; Makino Kosho; Tabata Hidetsugu; Nakayama Hiroshi; Zaitsu Kei; Oshitari Tetsuta; Natsugari Hideaki; Takahashi Hideyo

  HETEROCYCLES 96 (5) 914 - 924 0385-5414 2018/05 [Refereed]
  
• Atropisomerism in the 2,3,4,5-Tetrahydro-1H-1,5-benzodiazepine Nucleus: Effects of Central Chirality at C3 on the N-Mesylation Reaction.

  Tabata, Hidetsugu; Tsuji, Yuka; Yoneda, Tetsuya; Tasaka, Tomohiko; Oshitari, Tetsuta; Takahashi, Hideyo; Natsugari, Hideaki

  Synlett 29 (16) 2141 - 2146 2018 [Refereed]
  
• Elucidation of the E-Amide Preference of N-Acyl Azoles

  Yuka Takahashi; Hirotaka Ikeda; Yuki Kanase; Kosho Makino; Hidetsugu Tabata; Tetsuta Oshitari; Satoshi Inagaki; Yuko Otani; Hideaki Natsugari; Hideyo Takahashi; Tomohiko Ohwada

  JOURNAL OF ORGANIC CHEMISTRY AMER CHEMICAL SOC 82 (21) 11370 - 11382 0022-3263 2017/11 [Refereed]
  
• Comprehensive Quantitation Using Two Stable Isotopically Labeled Species and Direct Detection of N-Acyl Moiety of Sphingomyelin

  Kotaro Hama; Yuko Fujiwara; Hidetsugu Tabata; Hideyo Takahashi; Kazuaki Yokoyama

  LIPIDS SPRINGER HEIDELBERG 52 (9) 789 - 799 0024-4201 2017/09 [Refereed]
  
• Catalytic asymmetric S-oxidation of N-benzoyl-1,5-benzothiazepines

  Kosho Makino; Tetsuya Yoneda; Risa Ogawa; Yuki Kanase; Hidetsugu Tabata; Tetsuta Oshitari; Hideaki Natsugari; Hideyo Takahashi

  TETRAHEDRON LETTERS PERGAMON-ELSEVIER SCIENCE LTD 58 (30) 2885 - 2888 0040-4039 2017/07 [Refereed]
  
• Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active Form

  Hidetsugu Tabata; Tetsuya Yoneda; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  JOURNAL OF MEDICINAL CHEMISTRY AMER CHEMICAL SOC 60 (10) 4503 - 4509 0022-2623 2017/05 [Refereed]
  
• Electronic effects on the amide E-/Z-preference of N-benzoyl-carbazole derivatives

  Susumu Kayama; Norihiko Tani; Hidetsugu Tabata; Tetsuta Oshitari; Hideaki Natsugari; Hideyo Takahashi

  TETRAHEDRON LETTERS PERGAMON-ELSEVIER SCIENCE LTD 57 (22) 2395 - 2398 0040-4039 2016/06 [Refereed]
  
• Stereochemistry of N-Benzoyl-5-substituted-1-benzazepines Revisited: Synthesis of the Conformationally Biased Derivatives and Revision of the Reported Structure

  Hidetsugu Tabata; Tetsuya Yoneda; Tomohiko Tasaka; Shigekazu Ito; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  JOURNAL OF ORGANIC CHEMISTRY AMER CHEMICAL SOC 81 (8) 3136 - 3148 0022-3263 2016/04 [Refereed]
  
• Axial Chirality Originating in Amide and Sulfonamide Structures: Flexible Stereochemistry of Benzo-Fused Seven-Membered-Ring Heterocycles

  Tabata Hidetsugu; Yoneda Tetsuya; Takahashi Hideyo; Natsugari Hideaki

  Journal of Synthetic Organic Chemistry, Japan The Society of Synthetic Organic Chemistry, Japan 74 (1) 56 - 68 0037-9980 2016/01 [Refereed]
  
• Freezing the Butterfly Motion of Carbamazepine Derivatives

  Yuki Kanase; Mai Kuniyoshi; Hidetsugu Tabata; Yuka Takahashi; Susumu Kayama; Shintaro Wakamatsu; Tetsuta Oshitari; Hideaki Natsugari; Hideyo Takahashi

  SYNTHESIS-STUTTGART GEORG THIEME VERLAG KG 47 (24) 3907 - 3913 0039-7881 2015/12 [Refereed]
  
• Stereochemical properties of N-benzoylated carbazole derivatives

  Susumu Kayama; Hidetsugu Tabata; Yuka Takahashi; Norihiko Tani; Shintaro Wakamatsu; Tetsuta Oshitari; Hideaki Natsugari; Hideyo Takahashi

  TETRAHEDRON PERGAMON-ELSEVIER SCIENCE LTD 71 (38) 7046 - 7053 0040-4020 2015/09 [Refereed]
  
• Isolation of Atropisomers of N-​Benzoylated Pyrroles and Imidazoles

  Takahashi, Yuka; Wakamatsu, Shintaro; Tabata, Hidetsugu; Oshitari, Tetsuta; Natsugari, Hideaki; Takahashi, Hideyo

  SYNTHESIS-STUTTGART 47 (14) 2125 - 2128 2015/06 [Refereed]
  
• N-Benzoyl-1,5-benzothiazepine and Its S-Oxide as Vasopressin Receptor Ligands: Insight into the Active Stereochemistry around the Seven-Membered Ring

  Tetsuya Yoneda; Hidetsugu Tabata; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  JOURNAL OF MEDICINAL CHEMISTRY AMER CHEMICAL SOC 58 (7) 3268 - 3273 0022-2623 2015/04 [Refereed]
  
• Development of a Therapeutic Agent for Menkes Disease: Solubilization of a Copper-Disulfiram Complex

  Yujiro Hoshi; Norihiko Tani; Hidetsugu Tabata; Shintaro Wakamatsu; Mitsutoshi Munakata; Kazuo Maruyama; Hiroko Kodama; Tetsuta Oshitari; Hideaki Natsugari; Hideyo Takahashi

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN PHARMACEUTICAL SOC JAPAN 135 (3) 493 - 499 0031-6903 2015/03 [Refereed]
  
• N-Benzoyl- and N-Sulfonyl-1,5-benzodiazepines: Comparison of Their Atropisomeric and Conformational Properties

  Tetsuya Yoneda; Hidetsugu Tabata; Jun Nakagomi; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  JOURNAL OF ORGANIC CHEMISTRY AMER CHEMICAL SOC 79 (12) 5717 - 5727 0022-3263 2014/06 [Refereed]
  
• Crystallization-​induced diastereomeric transformation of N-​2'-​t-​butyl-​6'-​iodobenzoyl-​3-​bromocarbazole

  Kayama, Susumu; Tani, Norihiko; Takahashi, Yuka; Tabata, Hidetsugu; Wakamatsu, Shintaro; Oshitari, Tetsuta; Natsugari, Hideaki; Takahashi, Hideyo

  CHEMICAL & PHARMACEUTICAL BULLETIN 62 (8) 836 - 838 2014/03 [Refereed]
  
• A Complete Gear System in N-Benzoyl-Carbazole Derivatives

  Hidetsugu Tabata; Susumu Kayama; Yuka Takahashi; Norihiko Tani; Shintaro Wakamatsu; Tomohiko Tasaka; Tetsuta Oshitari; Hideaki Natsugari; Hideyo Takahashi

  ORGANIC LETTERS AMER CHEMICAL SOC 16 (5) 1514 - 1517 1523-7060 2014/03 [Refereed]
  
• Chemistry of amide-based axial chirality: Elucidation of the active conformation recognized by enzymes and receptors

  Hidetsugu Tabata

  Yakugaku Zasshi 133 (8) 857 - 866 1347-5231 2013/08 [Refereed]
  
• Stereochemistry of 1,5-Benzothiazepin-4-one S-Oxide: Insight into the Stereogenic Elements at the Sulfur Atom and Axis

  Hidetsugu Tabata; Tetsuya Yoneda; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  JOURNAL OF ORGANIC CHEMISTRY AMER CHEMICAL SOC 78 (12) 6264 - 6270 0022-3263 2013/06 [Refereed]
  
• Conformation and atropisomeric properties of indometacin derivatives

  Shintaro Wakamatsu; Yuka Takahashi; Hidetsugu Tabata; Tetsuta Oshitari; Norihiko Tani; Isao Azumaya; Yukiteru Katsumoto; Takeyuki Tanaka; Shinzo Hosoi; Hideaki Natsugari; Hideyo Takahashi

  Chemistry - A European Journal 19 (22) 7056 - 7063 0947-6539 2013/05 [Refereed]
  
• Synthesis of monofluoromethylcyclopropanes from alkenes without using freons: Novel synthesis of chlorofluoromethyl phenyl sulfide and its application in cyclopropanation

  Masayuki Kirihara; Tomomi Ogata; Atsushi Itou; Sayuri Naito; Mari Kishida; Kento Yamazaki; Hidetsugu Tabata; Hideyo Takahashi

  Chemistry Letters 42 (11) 1377 - 1379 0366-7022 2013 [Refereed]
  
• Isolation and Characterization of Atropisomers of Seven-Membered-Ring Benzolactams

  Hidetsugu Tabata; Naoya Wada; Yuko Takada; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  JOURNAL OF ORGANIC CHEMISTRY AMER CHEMICAL SOC 76 (12) 5123 - 5131 0022-3263 2011/06 [Refereed]
  
• Atropisomerism Observed in Indometacin Derivatives

  Hideyo Takahashi; Shintaro Wakamatsu; Hidetsugu Tabata; Tetsuta Oshitari; Ayako Harada; Keizo Inoue; Hideaki Natsugari

  ORGANIC LETTERS AMER CHEMICAL SOC 13 (4) 760 - 763 1523-7060 2011/02 [Refereed]
  
• Atropisomerism in the Vaptan Class of Vasopressin Receptor Ligands: The Active Conformation Recognized by the Receptor

  Hidetsugu Tabata; Jun Nakagomi; Daisuke Morizono; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION WILEY-V C H VERLAG GMBH 50 (13) 3075 - 3079 1433-7851 2011 [Refereed]
  
• Active Conformation of Seven-Membered-Ring Benzolactams as New ACAT Inhibitors: Latent Chiralityat N5 in the 1,5-Benzodiazepin-2-one Nucleus.

  Hidetsugu Tabata; Naoya Wada; Yuko Takada; Jun Nakagomi; Tomohiro Miike; Hiroaki Shirahase; Tetsuta Oshitari; Hideyo Takahashi; Natsugari Hideaki

  Chemistry A European Journal 18 (6) 1572 - 1576 2011 [Refereed]
  
• Atropisomeric Properties of 7-, 8-, and 9-Membered-Ring Dibenzolactams: Conformation, Thermal Stability, and Chemical Reactivity

  Hidetsugu Tabata; Hiroyuki Suzuki; Kumi Akiba; Hideyo Takahashi; Hideaki Natsugari

  JOURNAL OF ORGANIC CHEMISTRY AMER CHEMICAL SOC 75 (17) 5984 - 5993 0022-3263 2010/09 [Refereed]
  
• Axial chirality and affinity at the GABA(A) receptor of pyrimido[1,2-a][1,4]benzodiazepines and related compounds

  Shoukou Lee; Tomonori Kamide; Hidetsugu Tabata; Hideyo Takahashi; Motoo Shiro; Hideaki Natsugari

  BIOORGANIC & MEDICINAL CHEMISTRY PERGAMON-ELSEVIER SCIENCE LTD 16 (21) 9519 - 9523 0968-0896 2008/11 [Refereed]
  
• Atropisomeric Properties of the Dibenzo[b,d]azepin-6-one Nucleus

  Hidetsugu Tabata; Kumi Akiba; Shoukou Lee; Hideyo Takahashi; Hideaki Natsugari

  ORGANIC LETTERS AMER CHEMICAL SOC 10 (21) 4871 - 4874 1523-7060 2008/11 [Refereed]
  
• A recyclable catalytic system based on a temperature-responsive catalyst

  H Hamamoto; Y Suzuki; YMA Yamada; H Tabata; H Takahashi; S Ikegami

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION WILEY-V C H VERLAG GMBH 44 (29) 4536 - 4538 1433-7851 2005 [Refereed]
  
• Oxidation of allylic alcohols, amines, and sulfides mediated by assembled triphase catalyst of phosphotungstate and non-cross-linked amphiphilic copolymer

  YMA Yamada; H Tabata; M Ichinohe; H Takahashi; S Ikegami

  TETRAHEDRON PERGAMON-ELSEVIER SCIENCE LTD 60 (18) 4087 - 4096 0040-4020 2004/04 [Refereed]
  
• Oxidation of amines and sulfides catalyzed by an assembled complex of phosphotungstate and non-cross-linked amphiphilic polymer

  YMA Yamada; H Tabata; H Takahashi; S Ikegami

  SYNLETT GEORG THIEME VERLAG KG (12) 2031 - 2034 0936-5214 2002/12 [Refereed]
  

Conference Activities & Talks

• Atropodiastereoselective N-acylation of 1,5-benzodizepinones: Control of axial chirality by stereogenic center

  Hidetsugu Tabata; Kaoru Funaki; Yusuke Nakazato; Yuka Takahashi; Tomohiko Tasaka; Hideyo Takahashi; Hideaki Natsugari; Tetsuta Oshitari

  14th AFMC International Medicinal Chemistry Symposium  2023/06
• 中心不斉の導入による1,5-ベンゾジアゼピン誘導体の軸不斉制御

  舟木かおる; 田畑英嗣; 中里友亮; 髙橋由佳; 田坂友彦; 高橋秀依; 忍足鉄太; 夏苅英昭

  日本薬学会141年会  2021/03
• (S)-2-フェニルプロピオン酸塩化物を用いるN-アシル化反応による1,5-ベンゾジアゼピン誘導体の軸不斉選択的合成

  舟木かおる; 中里友亮; 田畑 英嗣; 髙橋由佳; 田坂友彦; 高橋秀依; 忍足鉄太; 夏苅英昭

  日本薬学140年会  2020/03
• 1,5-ベンゾジアゼピン誘導体の軸不斉と中心不斉に基づく立体化学

  舟木かおる; 田畑英嗣; 高橋由佳; 高橋秀依; 忍足鉄太; 夏苅英昭

  第78回有機合成化学協会関東支部シンポジウム  2019/11
• Conformational properties based on axial chirality of 6N-benzoyl- and 6N-p-tosyl-1,6-benzodiazocines: Comparison with these 1,5-benzodiazepines

  Hidetsugu Tabata*; Kaoru Funaki; Kazuya Murai; Chihiro Takemae; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  27th International Society of Heterocyclic Chemistry Congres  2019/09
• Stereochemistry and antiproliferative activity against cancer cells of 5N-sulfonyl-3-methyl-1,5-benzodiazepinones

  Hidetsugu Tabata*; Yuka Tsuji; Kaoru Funaki; Tetusya Yoneda; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  The Pharmaceutical Society of Japan, 139th Annual Meeting  2019/03
• Stereochemistry and antiproliferative activity against cancer cells of 5N-sulfonyl-3-methyl-1,5-benzodiazepin-2-ones

  Hidetsugu Tabata*; Yuka Tsuji; Kaoru Funaki; Tetsuya Yoneda; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  36th Medicinal Chemistry Symposium  2018/11
• 5N-Sulfonyl-1,5-benzodiazepin-2-ones: Atropisomeric properties and antiproliferation activity against cancer cells

  Hidetsugu Tabata*; Tetsuya Yoneda; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  第74回有機合成化学協会関東支部シンポジウム  2017/11
• N-Sulfonyl-1,5-benzodiazepin-2-ones: Atropisomeric properties and antiproliferation activity against cancer cells

  Hidetsugu Tabata*; Tetsuya Yoneda; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  The 35th Medicinal Chemistry Symposium  2017/10
• Stereochemistry and biological activity of 5-substituted N-benzoyl-1-benzazepines as vasopressin receptor antagonists

  Hidetsugu Tabata*; Tetsuya Yoneda; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  Chirality 2017  2017/07
• Stereochemistry and biological activity of 1,5-benzodiazepines as vasopressin receptor antagonists

  Hidetsugu Tabata*; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  The 34th Medicinal Chemistry Symposium  2016/11
• Stereochemistry and Vasopressin receptor inhibitory activity of Benzazepins

  Hidetsugu Tabata*; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  第72回有機合成化学協会関東支部シンポジウム  2016/11
• Stereochemistry and biological activity of N-acyl-1-benzazepine derivatives as vasopressin receptor antagonists

  Hidetsugu Tabata*; Tetsuya Yoneda; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  43th Symposium on Progress  2016/11
• Stereocheistry on N-benzoyl-1-benzoazepines

  Hidetsugu Tabata*; Tetsuya Yoneda; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  109th Symposium on Organic Synethesis  2016/06
• Stereochemistry and biological activity of 5-substituted N-acyl-1-benzazepine derivatives as vasopressin receptor antagonists

  Hidetsugu Tabata*; Tetsuya Yoneda; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  The 25th French-Japanese Symposium on Medicinal and Fine Chemistry  2016/05
• Stereochemistry and biological activity of 5-substituted N-acyl-1-benzazepine derivatives as vasopressin receptor antagonists

  Hidetsugu Tabata*; Tetsuya Yoneda; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  The 136th Annual Meeting of the Phaemaceutical Society of Japan  2016/03
• Stereochemistry and biological activity of 5-substituted N-acyl-1-bennzazepine derivatives as vasopressin receptor antagonists

  Hidetsugu Tabata*; Tetsuya Yoneda; Tomohiko Tasaka; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  The 33th Medicinal Chemistry Symposium  2015/11
• Stereochemistry of C5-substituted N-benzoyl-1-benzazepins

  Hidetsugu Tabata; Tetsuya Yoneda; Tetsuta Oshitari; Hideyo Takahashi; Hideaki Natsugari

  第70回有機合成化学協会関東支部シンポジウム  2015/11
• 7員環ベンゾラクタム類の軸性キラリティーと酵素（ACAT）阻害作用：1,5-ベンゾジアゼピン-2-オンのN5における隠れたキラリティー

  田畑英嗣

  第30回メディシナルケミストリーシンポジウム  2012/11
• アミド軸不斉の化学-生物活性発現に寄与する立体構造の解明研究-

  田畑英嗣

  第56回日本薬学会関東支部大会  2012/10

MISC

• Membrane permeability of diphenhydramine derivatives via H⁺/organic cation antiporter

  手賀悠真; 田畑英嗣; 黒澤俊樹; 北村敦; 板垣文雄; 忍足鉄太; 出口芳春  日本薬学会年会要旨集(CD-ROM)  140th-  2020
• ヒト血液脳関門におけるH⁺/有機カチオン交換輸送体の基質認識性についての検討

  手賀悠真; 田畑英嗣; 黒澤俊樹; 北村敦; 板垣文雄; 忍足鉄太; 出口芳春  日本薬剤学会年会講演要旨集(Web)  34th-  2019
• ヒト血液脳関門におけるH⁺/有機カチオン交換輸送体の基質探索研究

  手賀悠真; 田畑英嗣; 黒澤俊樹; 北村敦; 板垣文雄; 忍足鉄太; 出口芳春  日本薬学会関東支部大会講演要旨集  63rd-  2019
• 合成カンナビノイド誘導体の合成とGC-MS/MSによる位置異性体識別

  荒木拡嗣; 牧野宏章; 松本謙吾; 草野麻衣子; 財津桂; 田畑英嗣; 忍足鉄太; 夏苅英昭; 高橋秀依  日本薬学会関東支部大会講演要旨集  62nd-  2018
• Menkes病治療薬を志向した銅錯体の合成と物性

  谷紀彦; 田畑英嗣; 関むつみ; 鈴木亮; 丸山一雄; 宗形光敏; 廣木伴子; 児玉浩子; 夏苅英昭; 高橋秀依  日本DDS学会学術集会プログラム予稿集  30th-  2014
• 銅-ジスルフィラム錯体の可溶化

  星佑次郎; 谷紀彦; 田畑英嗣; 関むつみ; 鈴木亮; 丸山一雄; 宗形光敏; 児玉浩子; 忍足鉄太; 夏苅英昭; 高橋秀依  日本薬学会年会要旨集(CD-ROM)  134th-  2014
• Menkes病治療薬としての銅錯体の創出

  白承婀; 星祐次郎; 谷紀彦; 田畑英嗣; 関むつみ; 鈴木亮; 丸山一雄; 宗形光敏; 廣木伴子; 児玉浩子; 夏苅英昭; 高橋秀依  日本薬学会関東支部大会講演要旨集  57th-  2013
• Chemistry of Amide-based Axial Chirality: Elucidation of the Active Conformation Recognized by Enzymes and Receptors

  Tabata Hidetsugu  YAKUGAKU ZASSHI  133-  (8)  857  -866  2013
• A Recyclable Catalytic System Based on a Temperature-Responsive Catalyst

  Hiromi Hamamoto; Yachiyo Suzuki; Yoichi Yamada; Hidetsugu Tabata; Hideyo Takahashi; Shiro Ikegami  Angewandte Chemie, International Edition  44-  (29)  4536  -4538  2009
• γ-セクレターゼ阻害薬LY-411575のスキャフォルド,ジベンゾ[b,d]アゼピン-6-オン骨格の軸不斉の化学

  田畑英嗣; 秋葉久美; LEE Shoukou; 高橋宴子; 富田泰輔; 高橋秀依; 岩坪威; 夏苅英昭  メディシナルケミストリーシンポジウム講演要旨集  26th-  2007

Awards & Honors

• 2023/06 AIMECS2023 Best Poster Presentation Award
   Atropodiastereoselective N-acylation of 1,5-benzodizepinones: Control of axial chirality by stereogenic center
• 2012/10 The Pharmaceutical Society of Japan Kanto Branch incentive award
   アミド軸不斉の化学 -生物活性発現に寄与する立体構造の解明研究- 

  受賞者: Hidetsugu Tabata
• 2010/11 日本薬学会医薬化学部会 MCS merit award
   ベンゾアゼピノン誘導体の軸性キラリティーとACAT阻害活性―CDスペクトルは絶対配置の決め手になるか― 

  受賞者: Hidetsugu Tabata;Naoya Wada;Yuko Takada;Tetsuta Oshitari;Hideyo Takahashi;Tomohiro Miike;Masanori Kasai;Hiroaki Shirahase;Hideaki Natsugari
• 2007/05 Molecular Chirality 2007 merit award
   軸不斉を有するジベンゾアゼピノン誘導体の立体化学の解明 

  受賞者: Hidetsug Tabata;Kumi Akiba;Shoukou Lee;Hideyo Takahshi;Hideaki Natsugari

Research Grants & Projects

• Elucidation of axial chirality in sulfonamide and development of novel medicinal compounds

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016/04 -2020/03 

  Author : Tabata Hidetsugu
• Synthetic study on polymethoxyflavones: separation and enhancing of their biological activities

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2015/04 -2018/03 

  Author : Oshitari Tetsuta; Miyata Yoshiki; Tabata Hidetsugu
• Basic Research on Amide-based Axial Chirality and Development to Medicinal Chemistry

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2013/04 -2017/03 

  Author : Natsugari Hideaki; TABATA HIDETSUGU
• Stereochemistry based on the axial chirality and development of novel bioactive compounds

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2013/04 -2015/03 

  Author : TABATA Hidetsugu
• Synthesis and structure-activity relationships of polymethoxyflavones aimed at application to medical therapy of eye disease

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2015/03 

  Author : OSHITARI Tetsuta; KOSANO Hiroshi; MIYATA Yoshiki; TABATA Hidetsugu
• Elucidation of axial chirality and its application to medicinal chemistry

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2009 -2011 

  Author : NATSUGARI Hideaki; TABATA Hidetsugu
• Control of axial chirality and development of novel bioactive compounds with asymmetric axes.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2009 -2010 

  Author : TABATA Hidetsugu
• Basic Research on Dynamic Chirality and Its Application to Medicinal Chemistry

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2007 -2008 

  Author : NATSUGARI Hideaki; TABATA Hidetsugu