Yasuda Kunihiko

Researcher Information

Affiliation

Department of Occupational Therapy Professor

Degree

• Doctor of Science（2003/01 Kyoto University）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202201001177355019

Research funding number

• 50278446

J-Global ID

• 202201001177355019

Research Interests

• 老化、タンパク質の品質管理、mTORシグナル、アセチル化修飾   

Research Areas

• Life sciences / Nutrition and health science
• Life sciences / Laboratory animal science
• Life sciences / Molecular biology
• Life sciences / Cell biology

Academic & Professional Experience

• Teikyo UniversityFaculty of Fukuoka Medical Technology Department of Occupational Therapy
• Tokai Gakuin UniversityFaculty of Health and Welfare Department of Food and Health
• Nagasaki UniversityGraduate School of Biomedical Sciences
• Kyoto UniversityGraduate School of Biostudies
• Kyoto Pharmaceutical University

Education

•        -   Kyoto University  Graduate School of Science
•        -   Kyoto Pharmaceutical University  Graduate School of Pharmaceutical Sciences
•        -   Kyoto Pharmaceutical University  Pharmaceutical Sciences

Association Memberships

• 日本基礎老化学会   日本生化学会   日本分子生物学会   

Research Activity Information

Published Papers

• Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.

  Sho Kakizawa; Yasushi Kishimoto; Shinichiro Yamamoto; Kazuko Onga; Kunihiko Yasuda; Yoshiaki Miyamoto; Masahiko Watanabe; Ryuichi Sakai; Nozomu Mori

  Scientific reports 10 (1) 14475 - 14475 2020/09
• Involvement of the neuronal phosphotyrosine signal adaptor N-Shc in kainic acid-induced epileptiform activity.

  Shiro Baba; Kazuko Onga; Sho Kakizawa; Kyoji Ohyama; Kunihiko Yasuda; Hiroshi Otsubo; Brian W Scott; W McIntyre Burnham; Takayuki Matsuo; Izumi Nagata; Nozomu Mori

  Scientific reports 6 27511 - 27511 2016/06
• VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast.

  Yohei Ohnuma; Takahiro Takata; Junko Kawawaki; Kunihiko Yasuda; Keiji Tanaka; Yoko Kimura; Akira Kakizuka

  FEBS letters 589 (5) 576 - 80 0014-5793 2015/02
• Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression.

  Kunihiko Yasuda; Mayumi Takahashi; Nozomu Mori

  PloS one 10 (11) e0142943  2015
• Mdm20 stimulates polyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation.

  Kunihiko Yasuda; Kyoji Ohyama; Kazuko Onga; Akira Kakizuka; Nozomu Mori

  PloS one 8 (12) e82523  2013
• Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: Implications for co-operative versus non-co-operative actions of Mdm20 and Nat5

  Kyoji Ohyama; Kunihiko Yasuda; Kazuko Onga; Akira Kakizuka; Nozomu Mori

  Gene Expression Patterns 12 (1-2) 36 - 45 1567-133X 2012/01
• Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells.

  Nobuyuki Yamagishi; Masayasu Yokota; Kunihiko Yasuda; Youhei Saito; Kazuhiro Nagata; Takumi Hatayama

  Biochemical and biophysical research communications 409 (1) 90 - 5 0006-291X 2011/05
• Maintaining ATP levels via the suppression of PERK-mediated rRNA synthesis at ER stress.

  Akihiko Okamoto; Masaaki Koike; Kunihiko Yasuda; Akira Kakizuka

  Biochemical and biophysical research communications 394 (1) 42 - 7 0006-291X 2010/03
• p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.

  Chiho Mori-Konya; Naruyoshi Kato; Ryota Maeda; Kunihiko Yasuda; Naoki Higashimae; Masakatsu Noguchi; Masaaki Koike; Yoko Kimura; Hiroshi Ohizumi; Seiji Hori; Akira Kakizuka

  Genes to cells : devoted to molecular & cellular mechanisms 14 (4) 483 - 97 1356-9597 2009/04
• Targeted disruption of Hsp110/105 gene protects against ischemic stress.

  Junji Nakamura; Motoaki Fujimoto; Kunihiko Yasuda; Kiyoshi Takeda; Shizuo Akira; Takumi Hatayama; Yasushi Takagi; Kazuhiko Nozaki; Nobuko Hosokawa; Kazuhiro Nagata

  Stroke 39 (10) 2853 - 9 0039-2499 2008/10
• Stress protein assay for the evaluation of cytotoxicity of dental amalgam.

  Hiroshi Oshima; Masaaki Nakamura; Kunihiko Yasuda; Nobuyuki Yamagishi; Takumi Hatayama

  Journal of materials science. Materials in medicine 15 (1) 1 - 5 0957-4530 2004/01
• The Kruppel-like factor Zf9 and proteins in the Sp1 family regulate the expression of HSP47, a collagen-specific molecular chaperone.

  Kunihiko Yasuda; Kazunori Hirayoshi; Hiromi Hirata; Hiroshi Kubota; Nobuko Hosokawa; Kazuhiro Nagata

  The Journal of biological chemistry 277 (47) 44613 - 22 0021-9258 2002/11
• Phosphorylation of the 105-kDa heat shock proteins, HSP105α and HSP105β, by casein kinase II

  Keiichi Ishihara; Kunihiko Yasuda; Takumi Hatayama

  Biochemical and Biophysical Research Communications 270 (3) 927 - 931 0006-291X 2000/04
• Separate cis-acting DNA elements control cell type- and tissue-specific expression of collagen binding molecular chaperone HSP47

  Hiromi Hirata; Isao Yamamura; Kunihiko Yasuda; Akio Kobayashi; Norihiro Tada; Misao Suzuki; Kazunori Hirayoshi; Nobuko Hosokawa; Kazuhiro Nagata

  Journal of Biological Chemistry 274 (50) 35703 - 35710 0021-9258 1999/12
• Genomic cloning and promoter analysis of the mouse 105-kDa heat shock protein (HSP105) gene

  Kunihiko Yasuda; Keiichi Ishihara; Kazuo Nakashima; Takumi Hatayama

  Biochemical and Biophysical Research Communications 256 (1) 75 - 80 0006-291X 1999/03
• Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105

  Keiichi Ishihara; Kunihiko Yasuda; Takumi Hatayama

  Biochimica et Biophysica Acta - Gene Structure and Expression 1444 (1) 138 - 142 0167-4781 1999/01
• Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells

  Takumi Hatayama; Kiyoko Yasuda; Kunihiko Yasuda

  Biochemical and Biophysical Research Communications 248 (2) 395 - 401 0006-291X 1998/07
• Cloning and expression of murine high molecular mass heat shock proteins, HSP105

  Kunihiko Yasuda; Akira Nakai; Takumi Hatayama; Kazuhiro Nagata

  Journal of Biological Chemistry 270 (50) 29718 - 29723 0021-9258 1995/12
• Characterization of High-Molecular-Mass Heat Shock Proteins and 42°C-Specific Heat Shock Proteins of Murine Cells

  Takumi Hatayama; Kunihiko Yasuda; Eiji Nishiyama

  Biochemical and Biophysical Research Communications 204 (1) 357 - 365 0006-291X 1994/10
• Cellular Localization of High-Molecular-Mass Heat Shock Proteins in Murine Cells

  Takumi Hatayama; Eiji Nishiyama; Kunihiko Yasuda

  Biochemical and Biophysical Research Communications 200 (3) 1367 - 1373 0006-291X 1994/05

MISC

• Regulation of Intracellular Calcium Store by a Phosphotyrosine Adaptor ShcB in Cerebellar Purkinje Cells

  Sho Kakizawa; Yasushi Kishimoto; Shinichiro Yamamoto; Kazuko Onga; Kunihiko Yasuda; Ryuichi Sakai; Hiroshi Takeshima; Nozomu Mori  JOURNAL OF PHARMACOLOGICAL SCIENCES  121-  100P  -100P  2013

Research Grants & Projects

• マルチオミクスを用いた生体レジリエンスにおける老化統括制御分子の包括的解析

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2023/04 -2026/03 

  Author : 安田 邦彦
• アセチル化修飾によるmTORシグナルの陰陽制御機構と老化制御

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2019/04 -2022/03 

  Author : 安田 邦彦
• Regulation of neuronal ageing through the mTOR signaling by acetylation

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2014/04 -2018/03 

  Author : YASUDA KUNIHIKO; NAGATA Kazuhiro; OHYAMA Kyoji; NAKAYAMA Yuji; SAITO Yohei; MORI Nozomu
• Positive and negative regulations of cytoskeletal dynamism and neuronal lifespan

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

  Date (from‐to) : 2010/04 -2013/03 

  Author : MORI Nozomu; MASAHIKO Sibazaki; SHO Kakizawa; KYOJI Ohyama; KUNIHIKO Yasuda; YOKO Hiraishi-yamaguchi
• 神経変性疾患における巨胞形成と神経細胞死の分子機構の解明について

  日本学術振興会：科学研究費助成事業 特別研究員奨励費

  Date (from‐to) : 2003 -2005 

  Author : 安田 邦彦
• ジーンターゲッティング法によるストレスタンパク質HSP105の機能解析

  日本学術振興会：科学研究費助成事業 特別研究員奨励費

  Date (from‐to) : 1999 -2000 

  Author : 安田 邦彦
• Roles of stress protein hsp105 during mouse embryo development.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 1997 -1998 

  Author : HATAYAMA Takumi; YAMAGISHI Nobuyuki; YASUDA Kunihiko
• 高分子量ストレス蛋白質の構造と機能

  日本学術振興会：科学研究費助成事業 重点領域研究

  Date (from‐to) : 1995 -1995 

  Author : 畑山 巧; 安田 邦彦; 若槻 徹

Social Contribution

• 作業的サークルによる地域在住高齢者へのスマホ講座

  Date (from-to) : 2022/05/21-2022/07/09

  Category : Others
• 第３回東海地区理科研究発表会

  Date (from-to) : 2018/12

  Category : Seminar
• 「にんじんの生化学」（各務原市生涯学習・まちづくり出前講座2018（東海学院大学産官学連携「各務原にんじん」講座）））

  Date (from-to) : 2018

  Category : Visiting lecture
• 第2回東海地区理科研究発表会

  Date (from-to) : 2017/11

  Category : Seminar
• 第１回東海地区理科研究発表会

  Date (from-to) : 2016/11

  Category : Seminar
• 「ヒトの体の成り立ちと栄養素」（東海学院大学オープンキャンパス内）

  Date (from-to) : 2016/06

  Category : Visiting lecture
• AACL市民公開講座 in奈良国際奈良学セミナーハウス旧世尊院

  Date (from-to) : 2015/03

  Category : Seminar
• 日本基礎老化学会第36回大会

  Date (from-to) : 2013/06

  Category : Seminar
• 長崎市民講演会「老いをみつめる科学」

  Date (from-to) : 2011/11

  Category : Seminar