Kita Kayoko

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Associate Professor
Graduate School of Pharmaceutical Sciences Associate Professor

Degree

• pharmacology（Tohoku University）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901083579242974

J-Global ID

• 200901083579242974

Research Interests

• ヒ素化合物   環境汚染物質   arsenic compounds   environmental pollutant   

Research Areas

• Life sciences / Pharmaceuticals - health and biochemistry

Academic & Professional Experience

• 2016/04 - Today  Faculty of Pharmaceutical Sciences, Teikyo UniversityLaboratory of toxicologyassociate professor
• 2010/04 - 2016/03  Faculty of Pharmaceutical Sciences, Teikyo UniversityLaboratory of toxicologyLecturer
• 2007/04 - 2010/03  Faculty of Pharmaceutical Sciences, Teikyo UniversityLaboratory of toxicologyAssistant Professor
• 2005/04 - 2007/03  Faculty of Pharmaceutical Sciences, Teikyo UniversityLaboratory of toxicologyResearch Associate
• 2002/09 - 2005/03  Japanese Food Hygiene Associationresearch resident
• 2002/04 - 2002/08  Tohoku UniversityGraduate School of Pharmaceutical Sciences

Education

• 1999/04 - 2002/03  Tohoku University
•        - 2002  Tohoku University  Graduate School, Division of Pharmaceutical Sciences
• 1996/04 - 1998/03  University of Tsukuba  Master's Program in Health and Sport Sciences
•        - 1998  University of Tsukuba  Graduate School, Division of Physical Education
• 1992/04 - 1996/03  University of Tsukuba  School of Health and Physical Education
•        - 1996  University of Tsukuba  School of Health and Physical Education

Research Activity Information

Published Papers

• Enzyme from <i>Padina arborescens</i> Holmes Synthesizes Parinaric Acid, a Conjugated Tetraenoic Fatty Acid, from α-Linolenic Acid

  Hisaaki Ito; Taro Honma; Hidetsugu Tabata; Tomoyuki Koyama; Shigeaki Ueno; Kayoko Kita; Toshihide Suzuki

  Journal of Oleo Science Japan Oil Chemists' Society 73 (5) 743 - 749 1345-8957 2024
• BubR1 Is Essential for Thio-Dimethylarsinic Acid-Induced Spindle Assembly Checkpoint and Mitotic Cell Death for Preventing the Accumulation of Abnormal Cells

  Kayoko Kita; Yu Imai; Nanami Asaka; Toshihide Suzuki; Takafumi Ochi

  Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 42 (7) 1089 - 1097 0918-6158 2019/07
• Seeds of Centranthus ruber and Valeriana officinalis contain conjugated linolenic acids with reported antitumor effects

  T. Honma; N. Shiratani; Y. Banno; T. Kataoka; R. Kimura; I. Sato; Y. Endo; K. Kita; T. Suzuki; T. Takayanagi

  Journal of Oleo Science 68 (5) 481 - 491 2019/05 [Refereed]
  
• Arsenite-induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells

  Toshihide Suzuki; Hiroshi Watanabe; Kayoko Kita; Taro Honma; Takafumi Ochi

  Journal of Applied Toxicology John Wiley and Sons Ltd 38 (5) 734 - 743 1099-1263 2018/05 [Refereed]
  
• Effects of BubR1, a component of spindle assembly checkpoint protein, on mitotic cell accumulation induced by anti-microtubule agents

  KITA Kayoko; HARADA Yuko; SUZUKI Toshihide; OCHI Takafumi

  Annual Meeting of the Japanese Society of Toxicology The Japanese Society of Toxicology 43 P - 163 2016
• Daily Intake of Arsenic Compounds; its Chemical Form and Carcinogenic Risk

  KITA Kayoko

  Journal of Japan Society of Water Environment 日本水環境学会 ; 1992- 37(A) (11) 392 - 396 0916-8958 2014 [Refereed][Invited]
  
• Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines

  Toshihide Suzuki; Kayoko Kita; Takafumi Ochi

  Journal of Applied Toxicology 33 (8) 746 - 755 0260-437X 2013/08 [Refereed]
  
  ダウンロード
• Diphenylarsinic Acid Promotes Degradation of Glutaminase C by Mitochondrial Lon Protease

  Kayoko Kita; Toshihide Suzuki; Takafumi Ochi

  JOURNAL OF BIOLOGICAL CHEMISTRY 287 (22) 18163 - 18172 0021-9258 2012/05 [Refereed]
  
• Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines.

  Suzuki T; Kita K; Ochi T

  Journal of applied toxicology : JAT 33 (8) 746 - 55 0260-437X 2012/02 [Refereed]
  
• Diphenylarsinic acid produces behavioral effects in mice relevant to symptoms observed in citizens who ingested polluted well water

  Toyoshi Umezu; Kunichika Nakamiya; Kayoko Kita; Takafumi Ochi; Yasuyuki Shibata; Masatoshi Morita

  NEUROTOXICOLOGY AND TERATOLOGY 34 (1) 143 - 151 0892-0362 2012/01 [Refereed]
  
• siRNA-mediated AMPK alpha 1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells

  Gi-Wook Hwang; Mayumi Tobita; Tsutomu Takahashi; Shusuke Kuge; Kayoko Kita; Akira Naganuma

  JOURNAL OF TOXICOLOGICAL SCIENCES 35 (4) 601 - 604 0388-1350 2010/08 [Refereed]
  
• Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells

  Toshihide Suzuki; Koichi Miyazaki; Kayoko Kita; Takafumi Ochi

  TOXICOLOGY AND APPLIED PHARMACOLOGY 241 (3) 275 - 282 0041-008X 2009/12 [Refereed]
  
• Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds

  Kayoko Kita; Motohiro Sato; Toshihide Suzuki; Takafumi Ochi

  TOXICOLOGY 258 (2-3) 157 - 163 0300-483X 2009/04 [Refereed]
  
• c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

  Ping Gao; Irina Tchernyshyov; Tsung-Cheng Chang; Yun-Sil Lee; Kayoko Kita; Takafumi Ochi; Karen I. Zeller; Angelo M. De Marzo; Jennifer E. Van Eyk; Joshua T. Mendell; Chi V. Dang

  NATURE 458 (7239) 762 - U100 0028-0836 2009/04 [Refereed]
  
• Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione

  Takafurni Ochi; Kayoko Kita; Toshihide Suzuki; Alice Rumpler; Walter Goessler; Kevin A. Francesconi

  TOXICOLOGY AND APPLIED PHARMACOLOGY 228 (1) 59 - 67 0041-008X 2008/04 [Refereed]
  
• siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells

  Gi Wook Hwang; Tatsuya Hayashi; Kayoko Kita; Tsutomu Takahashi; Shusuke Kuge; Akira Naganuma

  Journal of Toxicological Sciences 5 32 (5) 581 - 583 0388-1350 2007/12 [Refereed]
  
• Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents

  Kayoko Kita; Toshihide Suzuki; Takafumi Ochi

  TOXICOLOGY AND APPLIED PHARMACOLOGY 220 (3) 262 - 270 0041-008X 2007/05 [Refereed]
  
• Potential effect on cellular response to cadmium of a single-nucleotide A -> G polymorphism in the promoter of the human gene for metallothionein IIA

  Kayoko Kita; Nobuhiko Miura; Minoru Yoshida; Kentaro Yamazaki; Takayoshi Ohkubo; Yutaka Imai; Akira Naganuma

  HUMAN GENETICS 120 (4) 553 - 560 0340-6717 2006/11 [Refereed]
  
• Glutathione plays a role in regulating the formation of toxic reactive intermediates from diphenylarsinic acid

  Kenji Kinoshita; Takafumi Ochi; Toshihide Suzuki; Kayoko Kita; Toshikazu Kaise

  TOXICOLOGY 225 (2-3) 142 - 149 0300-483X 2006/08 [Refereed]
  
• Genetic diversity of HIV type 1 in Likasi, southeast of the Democratic Republic of Congo.

  Kayoko Kita; Nicaise Ndembi; Michel Ekwalanga; Eiji Ido; Rigobert Kazadi; Blaise Bikandou; Jun Takehisa; Taichiro Takemura; Seiji Kageyama; Junji Tanaka; Henri Joseph Parra; Masanori Hayami; Hiroshi Ichimura

  AIDS research and human retroviruses 20 (12) 1352 - 7 0889-2229 2004/12
• Original MRE-binding transcription factor gene in normal humans is ZRF, not MTF-1

  Kayoko Kita; Nobuhiko Miura; Minoru Yoshida; Mitsunobu Matsubara; Yutaka Imai; Akira Naganuma

  Journal of health science 47 (6) 587 - 590 1344-9702 2001/09 [Refereed]
  
• Is allantoin in serum and urine a useful indicator of exercise-induced oxidative stress in humans?

  T Mikami; K Kita; S Tomita; GJ Qu; Y Tasaki; A Ito

  FREE RADICAL RESEARCH 32 (3) 235 - 244 1071-5762 2000 [Refereed]
  
• The antioxidant effects of urte and generation of allantoin during exhaustive exercise

  K Kita; T Mikami; GJ Qu; Y Tasaki; A Ito

  JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE 48 (1) 187 - 199 0039-906X 1999/02 [Refereed]
  

Conference Activities & Talks

• Relationship between chromosomal aberrations and centrosome maturation inhibition by Thio-DMA

  重留夏海; 北加代子; 本間太郎; 鈴木俊英

  メタルバイオサイエンス研究会2018  2018/11  Sendai  Biometals Specialty Section, The Japanese Society of Toxicology
  
• Effects of glutathione on the thio-dimethylarsinic acid-induced spindle assembly checkpoint

  北 加代子; 櫛原 理子; 関口 匠; 重留 夏海; 鈴木 俊英

  第44回日本毒性学会学術年会  2017/07
• チオ-ジメチルアルシン酸によるアポトーシス誘導に対する紡錘体チェックポイントタンパクBubR1の影響

  北 加代子; 安積 奈々美; 鈴木 俊英; 越智 崇文

  フォーラム2015 衛生薬学・環境トキシコロジー  2015/09

MISC

• c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism

  Ping Gao; Irina Tchernyshyov; Tsung-Cheng Chang; Yun-Sil Lee; Kayoko Kita; Takafumi Ochi; Karen Zeller; Angelo De Marzo; Jennifer Van Eyk; Joshua Mendell; Chi Dang  CANCER RESEARCH  69-  2009/05
• siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells.

  Gi-Wook Hwang; Tatsuya Hayashi; Kayoko Kita; Tsutomu Takahashi; Shusuke Kuge; Akira Naganuma  J.Toxico.Sci.  32-  (5)  581  -583  2007
• Potential effect on cellular response to cadmium of a single-nucleotide A -> G polymorphism in the promoter of the human gene for metallothionein IIA

  Kayoko Kita; Nobuhiko Miura; Minoru Yoshida; Kentaro Yamazaki; Takayoshi Ohkubo; Yutaka Imai; Akira Naganuma  HUMAN GENETICS  120-  (4)  553  -560  2006/11
• Protective effects of metallothioneln against cadmium-induced toxicity and polymorphisms of its gene(Molecular Mechanism for Toxicity of Metals, Proceedings of the 32nd Annual Meeting)

  Kita Kayoko  Journal of toxicological sciences  30-  S25  2005/10
• Original MRE-binding transcriptional factor gene in normal humans is ZRF, not MTF-1

  K Kita; N Miura; M Yoshida; M Matsubara; Y Imai; A Naganuma  JOURNAL OF HEALTH SCIENCE  47-  (6)  587  -590  2001/12
• Is allantoin in serum and urine a useful indicator of exercise-induced oxidative stress in humans?

  T Mikami; K Kita; S Tomita; GJ Qu; Y Tasaki; A Ito  FREE RADICAL RESEARCH  32-  (3)  235  -244  2000
• The antioxidant effects of urte and generation of allantoin during exhaustive exercise

  K Kita; T Mikami; GJ Qu; Y Tasaki; A Ito  JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE  48-  (1)  187  -199  1999/02

Awards & Honors

• 2011/10 The Pharmaceutical Society of Japan Specialty Section on Pharmaceutical Health Science and Environmental Toxicology Specialty Section on Pharmaceutical Health Science and Environmental Toxicology
   Regulation of the glutaminase C expression in the cells exposed to diphenylarsinic acid. japan_society 

  受賞者: KITA Kayoko
• 2007/09 メタロチオネインおよびメタルバイオサイエンス研究会 Study prize for encouragement
   Potential effect on cellular response to cadmium of a single-nucleotide A→G polymorphism in the promoter of the human gene for metallothionein IIA JPN japan_society 

  受賞者: Kayoko Kita

Research Grants & Projects

• ヒ素のメチル化代謝物が染色体の数の異常を引き起こす分子機構の解明

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2019/04 -2023/03 

  Author : 北 加代子
• Effects of diphenylarsinic acid on the cerebellar glutaminase activity

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

  Date (from‐to) : 2008 -2009 

  Author : KITA Kayoko
• 腎臓中のカドミウム蓄積量とメタロチオネイン濃度の関係

  その他の研究制度

  Date (from‐to) : 1999 -2005
• Relationship of Cadmium contents and metallothionein concentration in kidney

  The Other Research Programs

  Date (from‐to) : 1999 -2005
• 地下水ヒ素汚染物質ジフェニルアルシン酸による健康被害とその毒性メカニズムの解明

  その他の研究制度

  Date (from‐to) : 2005
• Search for target molecules of diphenylarsinic acid-induced toxicity

  The Other Research Programs

  Date (from‐to) : 2005