Sugiyama Toru

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Associate Professor
Graduate School of Pharmaceutical Sciences Associate Professor

Degree

• doctor of pharmacy（1992/03 The University of Tokyo）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201101029522639375

J-Global ID

• 201101029522639375

Research Interests

• ペプチド核酸   RecA   PNA   核酸化学   有機化学   ペプチド化学   ビタミンD   

Research Areas

• Life sciences / Pharmaceuticals - chemistry and drug development

Academic & Professional Experience

• 2015/04 - Today  Teikyo UniversityFaculty of Pharmaceutical Sciencesassociate professor

Education

• 1983/04 - 1987/03  The University of Tokyo  Faculty of Pharmaceutical Sciences  Department of Pharmacy

Association Memberships

• The Japanese Peptide Society   THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN   THE CHEMICAL SOCIETY OF JAPAN   THE PHARMACEUTICAL SOCIETY OF JAPAN   

Research Activity Information

Published Papers

• Isolation and identification of the new baicalin target protein to develop flavonoid structure-based therapeutic agents.

  Yoshio Kusakabe; Shun-Suke Moriya; Toru Sugiyama; Yoshiki Miyata

  Bioorganic & medicinal chemistry 90 117362 - 117362 2023/07
• Synthesis and properties of PNA containing a dicationic nucleobase based on N4-benzoylated cytosine.

  Shun-Suke Moriya; Kaoru Funaki; Yosuke Demizu; Masaaki Kurihara; Atsushi Kittaka; Toru Sugiyama

  Bioorganic & medicinal chemistry letters 88 129287 - 129287 2023/04 [Refereed]
  
• PreQ1塩基を持つペプチド核酸の合成とその性質

  森谷 俊介; 米田 有希; 桑田 啓子; 今村 保忠; 出水 庸介; 栗原 正明; 橘高 敦史; 杉山 亨

  日本薬学会年会要旨集 (公社)日本薬学会 142年会 27PO3 - 05 0918-9823 2022/03
• PreQ1 facilitates DNA strand invasion by PNA

  Shun-suke Moriya; Yuki Yoneta; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Atsushi Kittaka; Toru Sugiyama

  Peptide Science 2021 111 - 112 2022/03 [Refereed]
  
• Synthesis and characterization of PNA oligomers containing preQ1 as a positively charged guanine analogue

  Shun-suke Moriya; Hatsune Shibasaki; Misaki Kohara; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Atsushi Kittak; Toru Sugiyama

  Bioorganic and Medicinal Chemistry Letters 39 127850 - 127850 2021/05 [Refereed]
  
  ダウンロード
• Differentiation of Positional Isomers of Halogenated Benzoylindole Synthetic Cannabinoid Derivatives in Serum by Hybrid Quadrupole/Orbitrap Mass Spectrometry Anal. Sci. 37, 329-335 (2021)

  Tomoko Fukuuchi; Shun-suke Moriya; Toru Sugiyama; Hidetsugu Tabata; Kiyoko Kaneko

  Analytical Sciences 37 (2) 329 - 335 2020/09 [Refereed]
  
• ペプチド核酸によるdouble duplex invasionを応用した目視判定可能な一塩基多型検出系の検討

  森谷 俊介; 笹 祐子; 桑田 啓子; 今村 保忠; 出水 庸介; 栗原 雅明; 橘高 敦史; 杉山 亨

  日本薬学会年会要旨集 (公社)日本薬学会 140年会 27P - am008 0918-9823 2020/03
• An approach toward visual detection of single nucleotide polymorphism using pseudocomplementary peptide nucleic acid

  Shun-suke Moriya; Yuko Sasa; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Atsushi Kittaka; Toru Sugiyama

  Peptide Science 2019 173 - 174 2020/03 [Refereed]
  
• Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D3 Analogues.

  Fumihiro Kawagoe; Kaori Yasuda; Sayuri Mototani; Toru Sugiyama; Motonari Uesugi; Toshiyuki Sakaki; Atsushi Kittaka

  ACS omega 4 (6) 11332 - 11337 2019/06 [Refereed]
  
• PNA Oligomers Possessing PreQ1 as a Cationic Analogue of Guanine

  Toru Sugiyama; Hatsune Shibasaki; Shun-suke Moriya; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Atsushi Kittaka

  Peptide Science 2018 44  2019/04 [Refereed]
  
• Concise Synthesis of 23-Hydroxylated Vitamin D3 Metabolites

  Fumihiro Kawagoe; Toru Sugiyama; Kaori Yasuda; Motonari Uesugi; Toshiyuki Sakaki; Atsushi Kittaka

  Journal of Steroid Biochemistry and Molecular Biology 186 161 - 168 2018/10 [Refereed]
  
• Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine

  Toru Sugiyama; Misaki Kohara; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Atsushi Kittaka

  Peptide Science 2017 192 - 193 2018/03 [Refereed]
  
• Recent development for introducing a hexafluoroisopropanol unit into the Vitamin D side chain

  Fumihiro Kawagoe; Toru Sugiyama; Motonari Uesugi; Atsushi Kittaka

  Journal of Steroid Biochemistry and Molecular Biology 177 250 - 254 2017/07 [Refereed]
  
• Preparation of new Fmoc 2-thiouracil monomer for the synthesis of pseudo-complementary PNA

  Toru Sugiyama; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Peptide Science 2016 217 - 218 2017/04 [Refereed]
  
• PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA

  Toru Sugiyama; Genki Hasegawa; Chie Niikura; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Atsushi Kittaka

  Bioorganic and Medicinal Chemistry Letters Elsevier Ltd 27 (15) 3337 - 3341 1464-3405 2017 [Refereed]
  
• Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA

  Toru Sugiyama; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Peptide Science 2015 307 - 308 2016/03 [Refereed]
  
• Peptide nucleic acid with a lysine side chain at the β-position: Synthesis and application for DNA cleavage

  Toru Sugiyama; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Chemical and Pharmaceutical Bulletin Pharmaceutical Society of Japan 64 (7) 817 - 823 1347-5223 2016 [Refereed]
  
• Modified deazaguanines for the synthesis of PNA

  Toru Sugiyama; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Peptide Science 2014 87 - 88 2015/03 [Refereed]
  
• A Peptide Nucleic Acid to Reduce Type I Collagen Production by Fibroblast Cells

  Yasutada Imamura; Suzuka Tsuboi; Toru Sugiyama; Atsushi Kittaka; Yonchol Shin

  Open Journal of Medicinal Chemistry 5 (1) 1 - 8 2015/03 [Refereed]
  
• Sequence-specific cleavage of DNA by β-peptide nucleic acid bearing a pendant metal complex

  Toru Sugiyama; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Peptide Science 2013 369 - 370 2014 [Refereed]
  
• Synthesis of β-chiral peptide nucleic acids bearing lysine side chains

  Toru Sugiyama; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Peptide Science 2012 385 - 386 1344-7661 2013/03 [Refereed]
  
• Chiral peptide nucleic acids with a substituent in the N-(2-Aminoethy) glycine backbone

  Toru Sugiyama; Atsushi Kittaka

  Molecules MDPI AG 18 (1) 287 - 310 1420-3049 2013 [Refereed]
  
• Synthesis of β-chiral peptide nucleic acids and their DNA binding properties

  Toru Sugiyama; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Peptide Science 2011 353 - 354 1344-7661 2012/03 [Refereed]
  
• β-PNA: Peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone

  Toru Sugiyama; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Bioorganic & Medicinal Chemistry Letters 21 (24) 7317 - 7320 2011/10 [Refereed]
  
• Synthesis of 4-substituted chiral PNA monomers

  Toru Sugiyama; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Peptide Science 2010 284 - 284 1344-7661 2011/03 [Refereed]
  
• Sequence-specific cleavage of DNA by peptide nucleic acids conjugated with metal complexes

  Toru Sugiyama; Keiko Ninomiya; Yasutada Imamura; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  Peptide Science 2009 425 - 426 2010/03 [Refereed]
  
• Cooperative strand invasion by peptide nucleic acid

  Toru Sugiyama; Yasutada Imamura; Masaaki Kurihara; Atsushi Kittaka

  Peptide Science 2008 481 - 482 1344-7661 2009/03 [Refereed]
  
• Recognition of longer duplex DNA by cooperative strand invasion

  Toru Sugiyama; Yasutada Imamura; Masaaki Kurihara; Atsushi Kittaka

  Nucleic Acids Symposium Series (51) 269 - 270 2007/11 [Refereed]
  
• Sequence-specific recognition of double-stranded DNA by cooperative strand invasion

  Toru Sugiyama; Yasutada Imamura; Wataru Hakamata; Masaaki Kurihara; Atsushi Kittaka

  Nucleic Acids Symposium Series (50) 157 - 158 2006/11 [Refereed]
  
• Cooperative strand invasion of double-stranded DNA by peptide nucleic acid

  Toru Sugiyama; Yasutada Imamura; Wataru Hakamata; Masaaki Kurihara; Atsushi Kittaka

  Nucleic Acids Symposium Series (49) 167 - 168 2005/09 [Refereed]
  
• Schiff base formation between 5-formyl-2 '-deoxyuridine and lysine epsilon-amino group at monomer and oligomer levels

  A Kittaka; C Horii; H Tanaka; T Miyasaka; KT Nakamura; R Kuroda; T Sugiyama

  HETEROCYCLES PERGAMON-ELSEVIER SCIENCE LTD 64 367 - 382 0385-5414 2004/12 [Refereed]
  
• Topological stabilization of PNA-DNA invasion complex

  Toru Sugiyama; Reiko Kuroda; Atsushi Kittaka

  Nucleic Acids Symposium Series (48) 39 - 40 2004/11 [Refereed]
  
• Synthesis of PNA using a Fmoc/Boc protecting group strategy

  Toru Sugiyama; Atsushi Kittaka; Yohei Takemoto; Reiko Kuroda

  Peptide Science 2003 447 - 448 1344-7661 2004/03 [Refereed]
  
• Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by Schiff base-mediated crosslinking

  Toru Sugiyama; Atsushi Kittaka; Hiroaki Takayama; Mitsugu Tomioka; Yoshiteru Ida; Reiko Kuroda

  Bioorganic & Medicinal Chemistry Letters 13 (17) 2847 - 2851 2003/06 [Refereed]
  
• Synthesis of PNA using a Fmoc/Boc protecting group strategy

  Toru Sugiyama; Atsushi Kittaka; Yohei Takemoto; Hiroaki Takayama; Mitsugu Tomioka; Reiko Kuroda

  Nucleic Acids Research supplement (2) 145 - 146 2002/11 [Refereed]
  
• Evidence for a Schiff base formation of peptides derived from RecA with single-stranded oligonucleotides containing 5 formyl-2'-deoxyuridine

  Toru Sugiyama; Atsushi Kittaka; Hiroaki Takayama; Reiko Kuroda

  Nucleic Acids Research supplement (1) 175 - 176 2001/11 [Refereed]
  
• Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2 '-deoxyuridine

  T Sugiyama; A Kittaka; H Takayama; M Tomioka; Y Ida; R Kuroda

  NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS MARCEL DEKKER INC 20 (4-7) 1079 - 1083 1525-7770 2001 [Refereed]
  
• Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5 formyl-2'-deoxyuridine

  Toru Sugiyama; Atsushi Kittaka; Hiroaki Takayama; Mitsugu Tomioka; Yoshiteru Ida; Reiko Kuroda

  Nucleic Acids Symposium Series (44) 41 - 42 2000/10 [Refereed]
  
• Novel GG-specific DNA photocleavers: p-Cyanobenzamideterthiazole derivatives

  Keiko Ninomiya; Toru Sugiyama; Reiko Kuroda

  Nucleic Acids Symposium Series (42) 255 - 256 1999 [Refereed]
  
• Photocleavage of DNA by terthiazole-pyrrole-carboxamide hybrid compound

  Keiko Ninomiya; Toru Sugiyama; Reiko Kuroda

  Nucleic Acids Symposium Series (39) 231 - 232 1998 [Refereed]
  
• Mechanism of DNA-cleavage by photoactivated terthiazole-based compounds

  Keiko Ninomiya; Toru Sugiyama; Miho Shinomiya; Reiko Kuroda

  Nucleic Acids Symposium Series (35) 95 - 96 1996 [Refereed]
  
• Photoactivated thiazole-based DNA-cleaving agents: Dramatic change of recognition sequence depending on the number of thiazole units

  Keiko Ninomiya; Hiroshi Satoh; Toru Sugiyama; Miho Shinomiya; Reiko Kuroda

  Chemical Communications Royal Society of Chemistry (15) 1825 - 1826 1359-7345 1996 [Refereed]
  
• On the mechanism of enzymatic inactivation of bleomycin. The β-aminoalaninamide moiety as an enzyme-dependent molecular switch

  Toru Sugiyama; Masaji Ohno; Masakatsu Shibasaki; Masami Otsuka; Yukio Sugiura; Susumu Kobayashi; Kenji Maeda

  Bioorganic & Medicinal Chemistry Letters 4 (5) 705 - 710 1994/01 [Refereed]
  
• TRANSITION-METAL BINDING-SITE OF BLEOMYCIN - SIGNIFICANCE OF THE BETA-AMINOALANINAMIDE APPENDAGE IN REGULATING OXYGEN ACTIVATION

  T SUGIYAMA; M OHNO; M SHIBASAKI; M OTSUKA; Y SUGIURA; S KOBAYASHI; K MAEDA

  HETEROCYCLES PERGAMON-ELSEVIER SCIENCE LTD 37 (1) 275 - 282 0385-5414 1994/01 [Refereed]
  
• OXIDATION OF ALKENES BY A CHIRAL NON-PORPHYRINIC OXIDIZING CATALYST BASED ON THE BLEOMYCIN-FE(II) COMPLEX

  A SUGA; T SUGIYAMA; M OTSUKA; M OHNO; Y SUGIURA; K MAEDA

  TETRAHEDRON PERGAMON-ELSEVIER SCIENCE LTD 47 (7) 1191 - 1204 0040-4020 1991/02 [Refereed]
  
• Synthetic study toward the elucidation of the antitumor mechanism of bleomycin. –Role of the axial ligand and the linker moiety

  Takashi Owa; Toru Sugiyama; Akira Suga; Toshiyuki Nishio; Tetsuta Oshitari; Masami Otsuka; Susumu Kobayashi; Nobuo Tomioka; Akiko Itai; Masaji Ohno

  33rd symposium on the chemistry of natural products symposium paper Symposium on the chemistry of natural products (33) 321 - 328 1991 [Refereed]
  
• SYNTHETIC STUDIES ON ANTITUMOR ANTIBIOTIC BLEOMYCIN .30. A MODEL STUDY ON THE MECHANISM OF THE AUTOXIDATION OF BLEOMYCIN

  T OWA; T SUGIYAMA; M OTSUKA; M OHNO; K MAEDA

  TETRAHEDRON LETTERS PERGAMON-ELSEVIER SCIENCE LTD 31 (42) 6063 - 6066 0040-4039 1990 [Refereed]
  
• Transition-Metal Binding Site of Bleomycin. A Synthetic Analogue Superior to Bleomycin in Dioxygen-Activating Capability

  Akira Suga; Toru Sugiyama; Yuichi Sugano; Atsushi Kittaka; Masami Otsuka; Masaji Ohno; Yukio Sugiura; Kenji Maeda

  SYNLETT GEORG THIEME VERLAG KG (1) 70 - 71 0936-5214 1989 [Refereed]
  
• 71 DESIGN OF DNA CLEAVING MOLECULES BASED ON BLEOMYCIN : ENANTIOSELECTIVE SYNTHESIS OF NOVEL AMINO ACID CONSTITUENTS

  Owa T.; Haupt A.; Masuda T.; Kaku Y.; Sugiyama T.; Suga A.; Otsuka M.; Ohno M.; Sugiura Y.; Umezawa K.; Maeda K.

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (30) 548 - 555 1988/09

Conference Activities & Talks

• 新規カチオン性グアニンアナログをもつPNAオリゴマー

  森谷俊介; 柴崎初音; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史; 杉山 亨

  日本薬学会第１３９年会  2019/03
• PNA Oligomers Possessing PreQ1 as a Cationic Analogue of Guanine

  Toru Sugiyama; Hatsune Shibasaki; Shun-suke Moriya; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Atsushi Kittaka

  10th International Peptide Symposium  2018/12
• 正電荷を帯びたグアニン誘導体をもつPNAオリゴマーの合成

  杉山 亨; 柴崎初音; 森谷俊介; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史

  第３６回メディシナルケミストリーシンポジウム  2018/11
• β-アミノ酸を組み込んだ新規コラーゲン模倣物の創製

  下田 茜; 伊東未祐; 上村 光; 杉山 亨; 橘高敦史; 須原義智

  第３６回メディシナルケミストリーシンポジウム  2018/11
• 電荷を帯びたグアニンアナログをもつPNAオリゴマーの合成

  杉山 亨; 柴崎初音; 森谷俊介; 栗原正明; 橘高敦史

  第６２回日本薬学会関東支部大会  2018/09
• Synthesis of collagen mimetic incorporated β-amino acid

  Shimoda, Akane; Ito, Miyu; Uemura, Hikari; Sugiyama, Toru; Kittaka, Atsushi; Suhara, Yoshitomo

  256th ACS National Meeting & Exposition  2018/08
• グアニンPNAモノマーの新規カチオン性アナログ

  杉山 亨; 小原美咲; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史

  日本薬学会第１３８年会  2018/03
• 再生医療を指向したβ-アミノ酸を含む新規コラーゲン模倣物の創製

  下田 茜; 伊東未祐; 上村 光; 杉山 亨; 橘高敦史; 須原義智

  日本薬学会第１３８年会  2018/03
• Peptide Nucleic Acid possessing PreQ1 as a Cationic Analogue of Guanine

  杉山 亨; 小原美咲; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史

  第５４回ペプチド討論会  2017/11
• 正電荷を帯びたグアニン誘導体をもつPNAの合成

  杉山 亨; 小原美咲; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史

  第３５回メディシナルケミストリーシンポジウム  2017/10
• 電荷を帯びたグアニンアナログをもつPNAの合成

  杉山 亨; 小原美咲; 栗原正明; 橘高敦史

  第６１回日本薬学会関東支部大会  2017/09
• 標準的Fmoc法固相合成のための2-チオウラシルPNAモノマー

  杉山 亨; 長谷川元気; 新倉千絵; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史

  日本薬学会第１３７年会  2017/03
• Fmoc法による擬似相補的PNAの合成

  杉山 亨; 長谷川元気; 新倉千絵; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 高野真史; 橘高敦史

  第３４回メディシナルケミストリーシンポジウム  2016/11
• CF3TMSを用いたファレカルシトリオール誘導体の合成

  川越文裕; 高野真史; 杉山 亨; 上杉志成; 橘高敦史

  第３４回メディシナルケミストリーシンポジウム  2016/11
• New Fmoc 2-thiouracil monomer for the synthesis of pseudo-complementary PNA

  Toru Sugiyama

  第５３回ペプチド討論会  2016/10
• 機能性分子を目指した修飾デアザグアニンのペプチド核酸への導入

  杉山 亨; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 高野真史; 橘高敦史

  第４６回複素環化学討論会  2016/09
• Fmoc固相合成法のための擬似相補的PNAモノマーの開発

  杉山 亨; 長谷川元気; 新倉千絵; 栗原正明; 橘高敦史

  第６０回日本薬学会関東支部大会  2016/09
• デアザグアニン誘導体を持つPNAの合成

  杉山 亨; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 高野真史; 橘高敦史

  日本薬学会第１３６年会  2016/03
• 25-ヒドロキシビタミンD3ラクトン代謝産物と異性体の合成研究

  樋口恵理香; 杉山 亨; 高野真史; 上杉志成; 橘高敦史

  日本薬学会第１３６年会  2016/03
• 22-ヒドロキシ-2-メチリデン-19, 23, 24, 25, 26, 27-へキサノルビタミンD3と異性体の合成

  川越文裕; 高野真史; 松本洋太郎; 杉山 亨; 上杉志成; 橘高敦史

  日本薬学会第１３６年会  2016/03
• 修飾デアザグアニン含有PNAオリゴマーの合成

  杉山 亨; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 高野真史; 橘高敦史

  第３３回メディシナルケミストリーシンポジウム  2015/11
• Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA

  Toru Sugiyama

  第５２回ペプチド討論会  2015/11
• Incorporation of a peptide nucleic acid into a normal human fibroblast cell reduced type I collagen production

  Yasutada Imamura; Suzuka Tsuboi; Toru Sugiyama; Atsushi Kittaka; Yonchol Shin

  9th International Conference on Proteoglycans and 10th Pan Pacific Connective Tissue Societies Symposium  2015/08
• Sequence-Specific Cleavage of DNA by β-Peptide Nucleic Acid Bearing a Pendant Metal Complex

  Toru Sugiyama; Keiko Kuwata; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  4th Asia-Pacific International Peptide Symposium / 50th Japanese Peptide Symposium  2013/11
• Synthesis and DNA binding properties of β-chiral peptide nucleic acid

  Toru Sugiyama; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  8th AFMC International Medicinal Chemistry Symposium  2011/12
• Synthesis of 4-substituted chiral PNA monomers

  Toru Sugiyama; Yasutada Imamura; Yosuke Demizu; Masaaki Kurihara; Masashi Takano; Atsushi Kittaka

  5th International peptide Symposium  2010/12
• Recognition of longer duplex DNA by cooperative strand invasion

  Toru Sugiyama; Yasutada Imamura; Masaaki Kurihara; Atsushi Kittaka

  5th International Symposium on Nucleic Acids Chemistry  2007/11
• Cooperative strand invasion of double-stranded DNA by peptide nucleic acid

  Toru Sugiyama; Yasutada Imamura; Wataru Hakamata; Masaaki Kurihara; Atsushi Kittaka

  4th International Symposium on Nucleic Acids Chemistry  2005/09
• Interactions of peptides derived from E.coli RecA protein with single-stranded oligonucleotides containing 5-formyl-2’-deoxyuridine

  Toru Sugiyama; Atsushi Kittaka; Hiroaki Takayama; Mitsugu Tomioka; Yoshiteru Ida; Reiko Kuroda

  18th International Congress of Heterocyclic Chemistry  2001/07
• Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2’-deoxyuridine

  Toru Sugiyama; Atsushi Kittaka; Hiroaki Takayama; Mitsugu Tomioka; Yoshiteru Ida; Reiko Kuroda

  International Round Table Symposium XIV: Nucleosides, Nucleotides and Their Biological Applications  2000/09

MISC

• Cationic cytosine analogue of peptide nucleic acid monomer for enhanced DNA hybridization stability

  森谷俊介; 大石真菜; 出水庸介; 栗原正明; 橘高敦史; 杉山亨  日本薬学会年会要旨集(Web)  144th-  2024
• Synthesis of Dicationic Cytosine Derivative for Peptide Nucleic Acid

  MORIYA Shun-suke; YONEZU Misaki; KONDO Yuzu; DEMIZU Yosuke; KURIHARA Masaaki; KITTAKA Atsushi; SUGIYAMA Toru  Peptide Science  2022-  2023
• Synthesis of dicationic cytosine derivative for strand invasion with peptide nucleic acids

  森谷俊介; 米津実咲; 近藤有寿; 出水庸介; 栗原正明; 橘高敦史; 杉山亨  日本薬学会年会要旨集(Web)  143rd-  2023
• Synthesis and properties of peptide nucleic acid consisting of preQ₁

  森谷俊介; 米田有希; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史; 杉山亨  日本薬学会年会要旨集(Web)  142nd-  2022
• Strand-invasion of duplex DNA by peptide nucleic acid oligomers containing cationic guanine analogues

  森谷俊介; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史; 杉山亨  日本薬学会年会要旨集(Web)  141st-  2021
• 7-Aminomethy1-7-deazaguanineをもつPNAの合成

  森谷俊介; 柴崎初音; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史; 杉山亨  反応と合成の進歩シンポジウム講演要旨集  45th-  2019
• 標準的Fmoc法固相合成のための2‐チオウラシルPNAモノマー

  杉山亨; 長谷川元気; 新倉千絵; 桑田啓子; 今村保忠; 出水庸介; 栗原正明; 橘高敦史  日本薬学会年会要旨集(CD-ROM)  137th-  (2)  ROMBUNNO.25PA‐pm119  -182  2017/03
• 短い側鎖を有する19-ノルビタミンD誘導体の合成と生物活性評価

  川越文裕; 川越文裕; 高野真史; 松本洋太郎; 松本洋太郎; 竹内明子; 杉山亨; 上杉志成; 上杉志成; 橘高敦史; 橘高敦史  ビタミン  90-  (4)  2016
• SYNTHETIC STUDY TOWARD MAN-MADE BLEOMYCINS BY DEEPLY CONTRIBUTING TO THE ANTICANCER MECHANISM OF NATURAL BLEOMYCINS

  T OWA; T SUGIYAMA; A SUGA; M OTSUKA; M OHNO  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN  48-  (3)  194  -205  1990/03
• 二酸化炭素の光化学的固定

  杉山 亨  ファルマシア  25-  (12)  1253  -1253  1989/12

Research Grants & Projects

• Molecular design and synthesis of pseudo-complementary peptide nucleic acids capable of strand invasion without restriction

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2023/04 -2027/03 

  Author : 杉山 亨; 森谷 俊介; 出水 庸介
• Analysis of novel peptide nucleic acids against neurodegeneration

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2023/04 -2026/03 

  Author : 青山 晃治; 木下 千智; 松村 暢子; 杉山 亨
• アンチジーン法における配列制限の克服を目指したペプチド核酸の医薬分子設計

  日本学術振興会：科学研究費補助金 基盤研究（Ｃ）

  Date (from‐to) : 2018/04 -2021/03 

  Author : 杉山亨
• Study and development of a 14-epi-tachysterol skeleton and enhancing bone formation via flexibility of ligand binding domain of vitamin D receptor

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2015/03 

  Author : KITTAKA Atsushi; TAKANO Masashi; SAWADA Daisuke; SUGIYAMA Toru; SAKAKI Toshiyuki
• アンチジーン医薬を指向した光学活性ペプチド核酸の医薬分子設計

  日本学術振興会：科学研究費補助金 基盤研究（Ｃ）

  Date (from‐to) : 2012/04 -2015/03 

  Author : 杉山亨
• ストランドインベージョンを機序とするアンチジーン分子の医薬分子設計

  日本学術振興会：科学研究費補助金 基盤研究（Ｃ）

  Date (from‐to) : 2008/04 -2011/03 

  Author : 杉山亨
• Study on structural development of novel 14-epi-19-norprevitamin D type seco-steroids working on bone formation

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2009 -2011 

  Author : KITTAKA Atsushi; TAKANO Masashi; SAWADA Daisuke; SUGIYAMA Toru
• 14-epi-Previtamin D Analogs : Design and Synthesis of Selective Ligands for Nuclear Receptor and Membrane Receptor

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2007 -2008 

  Author : KITTAKA Atsushi; SAWADA Daisuke; TAKANO Masashi; SUGIYAMA Toru
• Development of selective nuclear receptor modulators with a 2,25-modified seco-steroidal skeleton

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2005 -2006 

  Author : KITTAKA Atsushi; SAITO Nozomi; TAKANO Masashi; SUGIYAMA Toru
• RecAタンパク質の相同性認識機構に学んだ人工リプレッサーの医薬分子設計

  日本学術振興会：科学研究費補助金 若手研究（B）

  Date (from‐to) : 2002/04 -2004/03 

  Author : 杉山亨
• Design and Synthesis of Vitamin D Receptor Antagonists : Remedy for Pagets Desease

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2003 -2004 

  Author : KITTAKA Atsushi; SAITO Nozomi; HONZAWA Shinobu; ARAI Midori; SUGIYAMA Toru
• DMA Lesions on the Specific Site in the Transcription Factor Binding Domain with RecA-Oligonucleotide Complexes

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2001 -2002 

  Author : KITTAKA Atsushi; NOZOMI Saito; SUHARA Yoshitomo; FUJISHIMA Toshie; SUGIYAMA Toru
• 任意の二重らせんDNAを標的とできる人工リプレッサーの医薬分子設計

  日本学術振興会：科学研究費補助金 奨励研究（A）

  Date (from‐to) : 2000/04 -2001/03 

  Author : 杉山亨
• 任意の二重らせんDNAを配列特異的に切断する人工ヌクレアーゼの医薬分子設計

  日本学術振興会：科学研究費補助金 奨励研究（A）

  Date (from‐to) : 1996/04 -1997/03 

  Author : 杉山亨
• 有機金属化合物によるDNA塩基配列の認識

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1995 -1995 

  Author : 黒田 玲子; 杉山 亨
• 腫瘍をターゲットとした新規ランタノイド化合物の開発

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1995 -1995 

  Author : 黒田 玲子; 杉山 亨
• Novel metal complex oligomer which forms triple helix with DNA

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1994 -1995 

  Author : KURODA Reiko; SUGIYAMA Toru
• 有機金属化合物によるDNA塩基配列の認識-機構の解明と新化合物の開発

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1994 -1994 

  Author : 黒田 玲子; 杉山 亨
• The chirality of metal complexes recognized by DNA and its significance towards biological activities

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1991 -1993 

  Author : KURODA Reiko; SUGIYAMA Toru; MATSUSHITA Nobuyuki