Researchers Database

Oohata Hirokazu

Advanced Comprehensive Research Organization (ACRO) Senior Assistant Professor

Last Updated :2026/09/02

Researcher Information

Affiliation

Advanced Comprehensive Research Organization (ACRO) Senior Assistant Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202201018948246977

J-Global ID

202201018948246977

Research Activity Information

Published Papers

オートファジー活性化による抗がん剤抵抗性獲得機構の解明(Activation of autophagy contributes to the chemoresistance in colon cancer)
大畑広和; 塩川大介; 岡本康司; 岡本康司
日本癌学会総会記事 (一社)日本癌学会 83回 J - 1002 0546-0476 2024/09

Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer
Yutaro Mori; Yoshie Okimoto; Hiroaki Sakai; Yusuke Kanda; Hirokazu Ohata; Daisuke Shiokawa; Mikiko Suzuki; Hiroshi Yoshida; Haruka Ueda; Tomoyuki Sekizuka; Ryo Tamura; Kaoru Yamawaki; Tatsuya Ishiguro; Raul Nicolas Mateos; Yuichi Shiraishi; Yasushi Yatabe; Akinobu Hamada; Kosuke Yoshihara; Takayuki Enomoto; Koji Okamoto
Cell Reports Medicine Elsevier BV 101532 - 101532 2666-3791 2024/04 [Refereed]

Elevated stress response marks deeply quiescent reserve cells of gastric chief cells.
Daisuke Shiokawa; Hiroaki Sakai; Miho Koizumi; Yoshie Okimoto; Yutaro Mori; Yusuke Kanda; Hirokazu Ohata; Hiroaki Honda; Koji Okamoto
Communications biology 6 (1) 1183 - 1183 2023/11 [Refereed]

大腸がん浸潤先端細胞とがん微小環境の相互作用によるがん進展メカニズムの解明(Development of colon cancer invasion front cells via interaction with tumor microenvironment)
塩川大介; 大畑広和; 岡本康司
日本癌学会総会記事 (一社)日本癌学会 82回 1179 - 1179 0546-0476 2023/09

PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway.
Hirokazu Ohata; Daisuke Shiokawa; Hiroaki Sakai; Yusuke Kanda; Yoshie Okimoto; Syuzo Kaneko; Ryuji Hamamoto; Hitoshi Nakagama; Koji Okamoto
Cell reports 42 (6) 112519 - 112519 2023/06 [Refereed]

Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer.
Toshiaki Miyazaki; Suyoun Chung; Hiroaki Sakai; Hirokazu Ohata; Yuuki Obata; Daisuke Shiokawa; Yukihiro Mizoguchi; Takashi Kubo; Hitoshi Ichikawa; Hirokazu Taniguchi; Kazunori Aoki; Tomoyoshi Soga; Hitoshi Nakagama; Koji Okamoto
Cancer science 113 (1) 170 - 181 2022/01 [Refereed]

NF-κB suppression synergizes with E7386, an inhibitor of CBP/β-catenin interaction, to block proliferation of patient-derived colon cancer spheroids.
Yusuke Kanda; Hirokazu Ohata; Toshiaki Miyazaki; Hiroaki Sakai; Yutaro Mori; Daisuke Shiokawa; Akira Yokoi; Takashi Owa; Atsushi Ochiai; Koji Okamoto
Biochemical and biophysical research communications 586 93 - 99 2022/01 [Refereed]

Establishment of in vitro 3D spheroid cell cultivation from human gynecologic cancer tissues.
Haruka Ueda; Yutaro Mori; Kaoru Yamawaki; Tatsuya Ishiguro; Hirokazu Ohata; Ai Sato; Kentaro Sugino; Nozomi Yachida; Manako Yamaguchi; Kazuaki Suda; Ryo Tamura; Kosuke Yoshihara; Koji Okamoto; Takayuki Enomoto
STAR protocols 2 (1) 100354 - 100354 2021/03 [Refereed]

Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer.
Daisuke Shiokawa; Hiroaki Sakai; Hirokazu Ohata; Toshiaki Miyazaki; Yusuke Kanda; Shigeki Sekine; Daichi Narushima; Masahito Hosokawa; Mamoru Kato; Yutaka Suzuki; Haruko Takeyama; Hideki Kambara; Hitoshi Nakagama; Koji Okamoto
Cancer research 80 (20) 4451 - 4464 2020/10 [Refereed]

ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer.
Yutaro Mori; Kaoru Yamawaki; Tatsuya Ishiguro; Kosuke Yoshihara; Haruka Ueda; Ai Sato; Hirokazu Ohata; Yohko Yoshida; Tohru Minamino; Koji Okamoto; Takayuki Enomoto
Stem cell reports 13 (4) 730 - 746 2019/10 [Refereed]

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression.
Hirokazu Ohata; Daisuke Shiokawa; Yuuki Obata; Ai Sato; Hiroaki Sakai; Mayu Fukami; Wakako Hara; Hirokazu Taniguchi; Masaya Ono; Hitoshi Nakagama; Koji Okamoto
Cell reports 28 (5) 1282 - 1295 2019/07 [Refereed]

The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells.
Daisuke Shiokawa; Ai Sato; Hirokazu Ohata; Michihiro Mutoh; Shigeki Sekine; Mamoru Kato; Tatsuhiro Shibata; Hitoshi Nakagama; Koji Okamoto
Cell reports 19 (5) 981 - 994 2017/05 [Refereed]

Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications.
Tatsuya Ishiguro; Hirokazu Ohata; Ai Sato; Kaoru Yamawaki; Takayuki Enomoto; Koji Okamoto
Cancer science 108 (3) 283 - 289 2017/03 [Refereed]

TNIK inhibition abrogates colorectal cancer stemness.
Mari Masuda; Yuko Uno; Naomi Ohbayashi; Hirokazu Ohata; Ayako Mimata; Mutsuko Kukimoto-Niino; Hideki Moriyama; Shigeki Kashimoto; Tomoko Inoue; Naoko Goto; Koji Okamoto; Mikako Shirouzu; Masaaki Sawa; Tesshi Yamada
Nature communications 7 12586 - 12586 2016/08 [Refereed]

Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.
Tatsuya Ishiguro; Ai Sato; Hirokazu Ohata; Yoshinori Ikarashi; Ryou-U Takahashi; Takahiro Ochiya; Masayuki Yoshida; Hitoshi Tsuda; Takashi Onda; Tomoyasu Kato; Takahiro Kasamatsu; Takayuki Enomoto; Kenichi Tanaka; Hitoshi Nakagama; Koji Okamoto
Cancer research 76 (1) 150 - 60 2016/01 [Refereed]

APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint.
Ryo Kikuchi; Hirokazu Ohata; Nobumichi Ohoka; Atsushi Kawabata; Mikihiko Naito
The Journal of biological chemistry 289 (6) 3457 - 67 2014/02 [Refereed]

Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system.
Takuro Horii; Sumiyo Morita; Mika Kimura; Ryouhei Kobayashi; Daiki Tamura; Ryou-U Takahashi; Hironobu Kimura; Isao Suetake; Hirokazu Ohata; Koji Okamoto; Shoji Tajima; Takahiro Ochiya; Yumiko Abe; Izuho Hatada
PeerJ 1 e230 2013/12 [Refereed]

NuMA is required for the selective induction of p53 target genes.
Hirokazu Ohata; Makoto Miyazaki; Ryo Otomo; Yuko Matsushima-Hibiya; Chihiro Otsubo; Takahiro Nagase; Hirofumi Arakawa; Jun Yokota; Hitoshi Nakagama; Yoichi Taya; Masato Enari
Molecular and cellular biology 33 (12) 2447 - 57 2013/06 [Refereed]

Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells.
Hirokazu Ohata; Tatsuya Ishiguro; Yuki Aihara; Ai Sato; Hiroaki Sakai; Shigeki Sekine; Hirokazu Taniguchi; Takayuki Akasu; Shin Fujita; Hitoshi Nakagama; Koji Okamoto
Cancer research 72 (19) 5101 - 10 2012/10 [Refereed]

miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.
Koji Okamoto; Tatsuya Ishiguro; Yutaka Midorikawa; Hirokazu Ohata; Masashi Izumiya; Naoto Tsuchiya; Ai Sato; Hiroaki Sakai; Hitoshi Nakagama
The EMBO journal 31 (7) 1752 - 63 2012/04 [Refereed]

Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.
Yoshimi Arima; Hidemi Hayashi; Mikako Sasaki; Mari Hosonaga; Takaaki M Goto; Tatsuyuki Chiyoda; Shinji Kuninaka; Tatsuhiro Shibata; Hirokazu Ohata; Hitoshi Nakagama; Yoichi Taya; Hideyuki Saya
The Journal of biological chemistry 287 (11) 7896 - 906 2012/03 [Refereed]

Differential expression of nanog1 and nanogp8 in colon cancer cells.
Tatsuya Ishiguro; Ai Sato; Hirokazu Ohata; Hiroaki Sakai; Hitoshi Nakagama; Koji Okamoto
Biochemical and biophysical research communications 418 (2) 199 - 204 2012/02 [Refereed]

Identification of a function-specific mutation of clathrin heavy chain (CHC) required for p53 transactivation.
Hirokazu Ohata; Nobuyuki Ota; Mikako Shirouzu; Shigeyuki Yokoyama; Jun Yokota; Yoichi Taya; Masato Enari
Journal of molecular biology 394 (3) 460 - 71 2009/12 [Refereed]

Monomeric but not trimeric clathrin heavy chain regulates p53-mediated transcription.
K Ohmori; Y Endo; Y Yoshida; H Ohata; Y Taya; M Enari
Oncogene 27 (15) 2215 - 27 2008/04 [Refereed]

Regulation of clathrin-mediated endocytosis by p53.
Yoshie Endo; Atsumi Sugiyama; Shun-Ai Li; Kazuji Ohmori; Hirokazu Ohata; Yusuke Yoshida; Masabumi Shibuya; Kohji Takei; Masato Enari; Yoichi Taya
Genes to cells : devoted to molecular & cellular mechanisms 13 (4) 375 - 86 2008/04 [Refereed]

Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function.
Yanyan Hao; Keiko Sekine; Atsushi Kawabata; Hitoshi Nakamura; Toshiyasu Ishioka; Hirokazu Ohata; Ryohei Katayama; Chizuko Hashimoto; Xiaodong Zhang; Tetsuo Noda; Takashi Tsuruo; Mikihiko Naito
Nature cell biology 6 (9) 849 - 60 1465-7392 2004/09 [Refereed]

3-methylcholanthrene activates human immunodeficiency virus type 1 replication via aryl hydrocarbon receptor.
Hirokazu Ohata; Toshifumi Tetsuka; Hidetoshi Hayashi; Kikuo Onozaki; Takashi Okamoto
Microbiology and immunology 47 (5) 363 - 70 0385-5600 2003 [Refereed]

MISC

Identification of a novel molecular regulator of chemoresistance in colorectal cancer
Hirokazu Ohata; Daisuke Shiokawa; Yusuke Kanda; Koji Okamoto CANCER SCIENCE 117- 1862 -1862 2026/01

Activation of autophagy contributes to the chemoresistance in colon cancer
大畑広和; 塩川大介; 岡本康司日本癌学会学術総会抄録集(Web) 83rd- 2024

シングルセルレベルでの遺伝子発現解析技術のがん研究への応用
塩川大介; 酒井宏明; 大畑広和; 神田裕介; 中釜斉; 岡本康司がんと代謝研究会プログラム&抄録集 9th- 2023

Development of colon cancer invasion front cells via interaction with tumor microenvironment
塩川大介; 大畑広和; 岡本康司日本癌学会学術総会抄録集(Web) 82nd- 2023

PROX1 induction by autophagy provide a persister-like state via repression of NOX1-mTORC1 pathway in colon cancer cells.
大畑広和; 塩川大介; 岡本康司日本癌学会学術総会抄録集(Web) 81st- 2022

Elucidation of chemoresistant niches of ovarian clear cell carcinoma via single-cell analyses & spatial transcriptomics
森裕太郎; 岡本康司; 神田裕介; 石黒竜也; 吉原弘祐; 榎本隆之; 山脇芳; 大畑広和; 塩川大介日本癌学会学術総会抄録集(Web) 81st- 2022

Crucial roles of quiescent cancer stem-like cells in colon carcinogenesis and tumor recurrence
塩川大介; 大畑広和; 岡本康司日本癌学会学術総会抄録集(Web) 78th- 2019

NOX1 induces mTORC1 activation and proliferation of colon cancer stem cells via interaction with Ca2+-binding proteins
Hirokazu Ohata; Daisuke Shiokawa; Koji Okamoto CANCER SCIENCE 109- 700 -700 2018/12

The slow-growing sub-population of Lgr5-positive colon tumor stem cells is resistant to an anti-cancer drug treatment
Daisuke Shiokawa; Hirokazu Ohata; Koji Okamoto CANCER SCIENCE 109- 185 -185 2018/12

The long isoform of Tcf1 is essential for the tumor-initiating activity of Lgr5-positive colon tumor stem cells
Daisuke Shiokawa; Hirokazu Ohata; Koji Okamoto CANCER SCIENCE 109- 438 -438 2018/01

mTORC1 activation by co-localized NADPH oxidase in colon cancer stem cells
Hirokazu Ohata; Daisuke Shiokawa; Koji Okamoto CANCER SCIENCE 109- 882 -882 2018/01

Wntシグナル遮断による大腸がん幹細胞根絶を目的としたTNIK阻害剤の開発
増田万里; 宇野佑子; 大畑広和; 森山英樹; 後藤尚子; 岡本康司; 澤匡明; 山田哲司日本癌学会総会記事 75回- IS2 -6 2016/10

Stra6は大腸がんの肝転移を抑制する
高橋賢太; 高橋賢太; 酒井宏晃; 佐藤愛; 大畑広和; 塩川大介; 村上康文; 岡本康司日本分子生物学会年会プログラム・要旨集(Web) 39th- 2016

Human ovarian cancer stem cells: In vitro cultivation and characterization
Tatsuya Ishiguro; Hirokazu Ohata; Hitoshi Nakagama; Koji Okamoto; Kenichi Tanaka; Takayuki Enomoto CANCER RESEARCH 74- (19) 2014/10

Research Grants & Projects

抗がん剤抵抗性を示す休止型大腸がん幹細胞を標的にした治療戦略の構築
日本学術振興会：科学研究費助成事業
Date (from‐to) : 2023/04 -2026/03
Author : 大畑広和

オートファジーによる静止期大腸がん幹細胞の維持機構の解明
日本学術振興会：科学研究費助成事業
Date (from‐to) : 2020/04 -2023/03
Author : 大畑広和

Identification of functional potassium channels in colon cancer stem cells
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2016/04 -2018/03
Author : Ohata Hirokazu

Analysis of mechanism of maintaining the stemness properties in human colon cancer stem cells using innovative spheroid culture system
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2012/04 -2014/03
Author : OHATA Hirokazu