Suzuki Toshihide

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Professor
Graduate School of Pharmaceutical Sciences Professor

Degree

• (BLANK)（Tohoku University）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901016604667064

J-Global ID

• 200901016604667064

Research Interests

• arsenic compounds   epigenetics   cytotoxicity   Toxicology   酸化ストレス   Free Radical   Oxidative Stress   

Research Areas

• Life sciences / Pharmaceuticals - health and biochemistry
• Life sciences / Molecular biology

Academic & Professional Experience

• 2015/04 - Today  Teikyo UniversityPharma-ScienceProfessor
• 2007/03 - 2015  Teikyo UniversityPharma-ScienceAssociate Professor
• 2000/01 - 2007/03  Teikyo UniversityPharmaceutical SciencesResearch Associate
• 1998/10 - 1999/12  Albany Medical College, Postdoctoral Fellow
• 1993/04 - 1998/10  Teikyo UniversityPharmaceutical SciencesResearch Associate

Education

• 1988/04 - 1993/03  Tohoku University  Graduate School of Agriculture  Food Chemistry
• 1984/04 - 1988/03  Tohoku University  Agriculture  Food Chemistry

Association Memberships

• 日本分子生物学会   生体パーオキサイト研究会   日本過酸化脂質・フリーラジカル学会   日本薬学会   The Japanese Society of Lipid Peroxide and Free Radical Research   The Molecular Biology Society of Japan   The Pharmaceutical Society of Japan   International Society for Free Radical Research   

Research Activity Information

Published Papers

• BubR1 Is Essential for Thio-Dimethylarsinic Acid-Induced Spindle Assembly Checkpoint and Mitotic Cell Death for Preventing the Accumulation of Abnormal Cells

  Kayoko Kita; Yu Imai; Nanami Asaka; Toshihide Suzuki; Takafumi Ochi

  Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 42 (7) 1089 - 1097 0918-6158 2019/07 [Refereed]
  
• Seeds of Centranthus ruber and Valeriana officinalis contain conjugated linolenic acids with reported antitumor effects

  T. Honma; N. Shiratani; Y. Banno; T. Kataoka; R. Kimura; I. Sato; Y. Endo; K. Kita; T. Suzuki; T. Takayanagi

  Journal of Oleo Science 68 (5) 481 - 491 2019/05 [Refereed]
  
• Arsenite-induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells

  Toshihide Suzuki; Hiroshi Watanabe; Kayoko Kita; Taro Honma; Takafumi Ochi

  Journal of Applied Toxicology John Wiley and Sons Ltd 38 (5) 734 - 743 1099-1263 2018/05 [Refereed]
  
• Effects of BubR1, a component of spindle assembly checkpoint protein, on mitotic cell accumulation induced by anti-microtubule agents

  KITA Kayoko; HARADA Yuko; SUZUKI Toshihide; OCHI Takafumi

  Annual Meeting of the Japanese Society of Toxicology The Japanese Society of Toxicology 43 P - 163 2016
• Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines

  Toshihide Suzuki; Kayoko Kita; Takafumi Ochi

  Journal of Applied Toxicology 33 (8) 746 - 755 0260-437X 2013/08 [Refereed]
  
• Diphenylarsinic Acid Promotes Degradation of Glutaminase C by Mitochondrial Lon Protease

  Kayoko Kita; Toshihide Suzuki; Takafumi Ochi

  JOURNAL OF BIOLOGICAL CHEMISTRY 287 (22) 18163 - 18172 0021-9258 2012/05 [Refereed]
  
• Significance of Lutein in Red Blood Cells of Alzheimer's Disease Patients

  Takehiro Kiko; Kiyotaka Nakagawa; Tsuyoshi Tsuduki; Toshihide Suzuki; Hiroyuki Arai; Teruo Miyazawa

  JOURNAL OF ALZHEIMERS DISEASE 28 (3) 593 - 600 1387-2877 2012 [Refereed]
  
• 認知症者における過酸化脂質蓄積赤血球の出現とその生成機構

  宮澤大樹; 仲川清隆; 喜古健敬; 鈴木俊英; 荒井啓行; 宮澤陽夫

  脂質生化学研究 53 66 - 69 2011/04 [Refereed][Invited]
  
• Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells

  Toshihide Suzuki; Koichi Miyazaki; Kayoko Kita; Takafumi Ochi

  TOXICOLOGY AND APPLIED PHARMACOLOGY 241 (3) 275 - 282 0041-008X 2009/12 [Refereed]
  
• Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds

  Kayoko Kita; Motohiro Sato; Toshihide Suzuki; Takafumi Ochi

  TOXICOLOGY 258 (2-3) 157 - 163 0300-483X 2009/04 [Refereed]
  
• Preparation of pure lipid hydroperoxides

  Daigo Ibusuki; Kiyotaka Nakagawa; Akira Asai; Shinichi Oikawa; Yuichi Masuda; Toshihide Suzuki; Teruo Miyazawa

  JOURNAL OF LIPID RESEARCH 49 (12) 2668 - 2677 0022-2275 2008/12 [Refereed]
  
• Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione

  Takafurni Ochi; Kayoko Kita; Toshihide Suzuki; Alice Rumpler; Walter Goessler; Kevin A. Francesconi

  TOXICOLOGY AND APPLIED PHARMACOLOGY 228 (1) 59 - 67 0041-008X 2008/04 [Refereed]
  
• Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents

  Kayoko Kita; Toshihide Suzuki; Takafumi Ochi

  TOXICOLOGY AND APPLIED PHARMACOLOGY 220 (3) 262 - 270 0041-008X 2007/05 [Refereed]
  
• Glutathione plays a role in regulating the formation of toxic reactive intermediates from diphenylarsinic acid

  Kenji Kinoshita; Takafumi Ochi; Toshihide Suzuki; Kayoko Kita; Toshikazu Kaise

  TOXICOLOGY 225 (2-3) 142 - 149 0300-483X 2006/08 [Refereed]
  
• The role of glutathione on the cytotoxic effects and cellular uptake of diphenylarsinic acid, a degradation product of chemical warfare agents

  T Ochi; K Kinoshita; T Suzuki; K Miyazaki; A Noguchi; T Kaise

  ARCHIVES OF TOXICOLOGY 80 (8) 486 - 491 0340-5761 2006/08 [Refereed]
  
• Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5 '-phosphate as the inhibitor

  O Higuchi; K Nakagawa; T Tsuzuki; T Suzuki; S Oikawa; T Miyazawa

  JOURNAL OF LIPID RESEARCH 47 (5) 964 - 974 0022-2275 2006/05 [Refereed]
  
• Evaporative light-scattering analysis of sulforaphane in broccoli samples: Quality of broccoli products regarding sulforaphane contents

  K Nakagawa; T Umeda; O Higuchi; T Tsuzuki; T Suzuki; T Miyazawa

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 54 (7) 2479 - 2483 0021-8561 2006/04 [Refereed]
  
• Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: A dual mechanism approach

  T Eitsuka; K Nakagawa; T Suzuki; T Miyazawa

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1737 (1) 1 - 10 1388-1981 2005/10 [Refereed]
  
• Oxidative damages in isolated rat hepatocytes treated with the organochlorine fungicides captan, dichlofluanid and chlorothalonil

  T Suzuki; H Nojiri; H Isono; T Ochi

  TOXICOLOGY 204 (2-3) 97 - 107 0300-483X 2004/11 [Refereed]
  
• In vitro cytotoxic and genotoxic effects of diphenylarsinic acid, a degradation product of chemical warfare agents

  T Ochi; T Suzuki; H Isono; T Kaise

  TOXICOLOGY AND APPLIED PHARMACOLOGY 200 (1) 64 - 72 0041-008X 2004/10 [Refereed]
  
• A trivalent dimethylarsenic compound, dimethylarsine iodide, induces cellular transformation, aneuploidy, centrosome abnormality and multipolar spindle formation in Syrian hamster embryo cells

  T Ochi; T Suzuki; JC Barrett; T Tsutsui

  TOXICOLOGY 203 (1-3) 155 - 163 0300-483X 2004/10 [Refereed]
  
• Oxidation rate of conjugated linoleic acid and conjugated linolenic acid is slowed by triacylglycerol esterification and alpha-tocopherol

  T Tsuzuki; M Igarashi; T Iwata; Y Yamauchi-Sato; T Yamamoto; K Ogita; T Suzuki; T Miyazawa

  LIPIDS 39 (5) 475 - 480 0024-4201 2004/05 [Refereed]
  
• Induction of structural and numerical changes of chromosome, centrosome abnormality, multipolar spindles and multipolar division in cultured Chinese hamster V79 cells by exposure to a trivalent dimethylarsenic compound

  T Ochi; T Suzuki; H Isono; C Schlagenhaufen; W Goessler; T Tsutsui

  MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 530 (1-2) 59 - 71 0027-5107 2003/09 [Refereed]
  
• Dietary supplementation with docosahexaenoic acid, but not with eicosapentaenoic acid, reduces host resistance to fungal infection in mice

  M Oarada; T Tsuduki; T Suzuki; T Miyazawa; T Nikawa; G Hong-quan; N Kurita

  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1622 (3) 151 - 160 0304-4165 2003/08 [Refereed]
  
• Glycotherapy for cancer: remodeling of ganglioside pattern as an effective approach for cancer therapy

  H Nojiri; H Yamana; G Shirouzu; T Suzuki; H Isono

  CANCER DETECTION AND PREVENTION 26 (2) 114 - 120 0361-090X 2002 [Refereed]
  
• Mammalian resistance to oxidative stress: A comparative analysis

  T Suzuki; DR Spitz; P Gandhi; HY Lin; DR Crawford

  GENE EXPRESSION 10 (4) 179 - 191 1052-2166 2002 [Refereed]
  
• Maf genes are involved in multiple stress response in human

  T Suzuki; Blank, V; JS Sesay; DR Crawford

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 280 (1) 4 - 8 0006-291X 2001/01 [Refereed]
  
• Simple pretreatment method for monitoring of norephedrine in urine and tyramine in food sample using liquid-liquid extraction

  H Isono; T Suzuki; H Nojiri

  JOURNAL OF HEALTH SCIENCE 46 (5) 351 - 357 1344-9702 2000/10 [Refereed]
  
• Control selection for RNA quantitation

  T Suzuki; PJ Higgins; DR Crawford

  BIOTECHNIQUES 29 (2) 332 - + 0736-6205 2000/08 [Refereed]
  
• Repressing effects of sodium dodecyl sulfate on solvent-gelatinization of urine samples

  H Isono; H Seto; T Suzuki; H Nojiri

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 45 (2) 43 - 52 0013-273X 1999/04 [Refereed]
  
• Deproteinization of urine sample for liquid-liquid extraction of basic chemicals

  H Isono; T Matsuzawa; T Suzuki; H Nojiri

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 43 (5) 261 - 273 0013-273X 1997/10 [Refereed]
  
• Cytotoxicity of organochlorine pesticides and lipid peroxidation in isolated rat hepatocytes

  T Suzuki; M Komatsu; H Isono

  BIOLOGICAL & PHARMACEUTICAL BULLETIN 20 (3) 271 - 274 0918-6158 1997/03 [Refereed]
  
• Cytotoxicity of organochlorine pesticides and lipid peroxidation in rat hepatocytes

  T Suzuki; M Komatsu; H Isono

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 43 (1) P5 - P5 0013-273X 1997/02 [Refereed]
  
• Cytotoxicity of trihalomethanes and lipid peroxidation in isolated rat hepatocytes

  T Suzuki; M Komatsu; H Isono

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 42 (6) 479 - 486 0013-273X 1996/12 [Refereed]
  
• Separation of urinary foaming material by bubbling of urine and by gelatinizing of solvent with foam

  H Isono; M Komatsu; T Suzuki; H Nojiri

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 42 (4) 292 - 300 0013-273X 1996/08 [Refereed]
  
• Age-related change of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide levels in normal human red blood cells

  T Miyazawa; T Suzuki; K Fujimoto; M Kinoshita

  MECHANISMS OF AGEING AND DEVELOPMENT 86 (3) 145 - 150 0047-6374 1996/03 [Refereed]
  
• Cytotoxicity of paraquat and phospholipid peroxidation in rat hepatocytes

  T Suzuki; M Komatsu; H Isono

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 42 (1) P10 - P10 0013-273X 1996/02 [Refereed]
  
• CYTOTOXICITY OF HALOGENATED HYDROCARBONS AND CELLULAR PHOSPHOLIPID PEROXIDATION IN ISOLATED RAT HEPATOCYTES

  T SUZUKI; M KOMATSU; H SASAKI; H ISONO

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 41 (1) P35 - P35 0013-273X 1995/02 [Refereed]
  
• CYTOTOXICITY OF 1,3-DICHLOROPROPENE AND CELLULAR PHOSPHOLIPID PEROXIDATION IN ISOLATED RAT HEPATOCYTES, AND ITS PREVENTION BY ALPHA-TOCOPHEROL

  T SUZUKI; H SASAKI; M KOMATSU; T MIYAZAWA; H ISONO

  BIOLOGICAL & PHARMACEUTICAL BULLETIN 17 (10) 1351 - 1354 0918-6158 1994/10 [Refereed]
  
• EVALUATION OF INTERACTION OF PARAQUAT WITH LECITHIN OR CASEIN BY PARAMECIUM

  H ISONO; H SASAKI; T SUZUKI

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 40 (2) 132 - 139 0013-273X 1994/04 [Refereed]
  
• CYTOTOXICITY OF CHLORINATED HYDROCARBONS AND LIPID-PEROXIDATION IN ISOLATED RAT HEPATOCYTES

  T SUZUKI; H SASAKI; H ISONO

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 40 (1) P28 - P28 0013-273X 1994/02 [Refereed]
  
• CYTOTOXICITY OF CHLORINATED HYDROCARBONS AND LIPID-PEROXIDATION IN ISOLATED RAT HEPATOCYTES

  T SUZUKI; K NEZU; H SASAKI; T MIYAZAWA; H ISONO

  BIOLOGICAL & PHARMACEUTICAL BULLETIN 17 (1) 82 - 86 0918-6158 1994/01 [Refereed]
  
• ELIMINATION OF PLASMA PHOSPHATIDYLCHOLINE HYDROPEROXIDE BY A SELENOORGANIC COMPOUND, EBSELEN

  T MIYAZAWA; T SUZUKI; K FUJIMOTO; M KINOSHITA

  JOURNAL OF BIOCHEMISTRY 114 (4) 588 - 591 0021-924X 1993/10 [Refereed]
  
• AGE-DEPENDENT ACCUMULATION OF PHOSPHATIDYLCHOLINE HYDROPEROXIDE IN THE BRAIN AND LIVER OF THE RAT

  T MIYAZAWA; T SUZUKI; K FUJIMOTO

  LIPIDS 28 (9) 789 - 793 0024-4201 1993/09 [Refereed]
  
• AGE-RELATED ACCUMULATION OF PHOSPHATIDYLCHOLINE HYDROPEROXIDE IN CULTURED HUMAN-DIPLOID CELLS AND ITS PREVENTION BY ALPHA-TOCOPHEROL

  T SUZUKI; T MIYAZAWA; K FUJIMOTO; M OTSUKA; M TSUTSUMI

  LIPIDS 28 (8) 775 - 778 0024-4201 1993/08 [Refereed]
  
• CHEMILUMINESCENT DETECTION OF THYMINE HYDROPEROXIDES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

  R SAEKI; H INABA; T SUZUKI; T MIYAZAWA

  JOURNAL OF CHROMATOGRAPHY 606 (2) 187 - 193 0021-9673 1992/08 [Refereed]
  
• CHEMILUMINESCENT SIMULTANEOUS DETERMINATION OF PHOSPHATIDYLCHOLINE HYDROPEROXIDE AND PHOSPHATIDYLETHANOLAMINE HYDROPEROXIDE IN THE LIVER AND BRAIN OF THE RAT

  T MIYAZAWA; T SUZUKI; K FUJIMOTO; K YASUDA

  JOURNAL OF LIPID RESEARCH 33 (7) 1051 - 1058 0022-2275 1992/07 [Refereed]
  
• PHOSPHOLIPID HYDROPEROXIDE ACCUMULATION IN LIVER OF RATS INTOXICATED CARBON-TETRACHLORIDE AND ITS PREVENTION BY ALPHA-TOCOPHEROL

  T MIYAZAWA; T SUZUKI; K FUJIMOTO

  OXIDATIVE DAMAGE & REPAIR 82 - 86 1991 [Refereed]
  
• PHOSPHOLIPID HYDROPEROXIDE ACCUMULATION IN LIVER OF RATS INTOXICATED WITH CARBON-TETRACHLORIDE AND ITS INHIBITION BY DIETARY ALPHA-TOCOPHEROL

  T MIYAZAWA; T SUZUKI; K FUJIMOTO; T KANEDA

  JOURNAL OF BIOCHEMISTRY 107 (5) 689 - 693 0021-924X 1990/05 [Refereed]
  

Books etc

• 衛生薬学 第3版

  鈴木俊英 (Joint work電離放射線と非電離放射線)朝倉書店 2013 pp. 389-402
• 食品の機能化学

  鈴木俊英 (Joint work脂質の酸化)アイ・ケイ コーポレーション 2010 pp. 95-115
• 環境・健康科学事典

  鈴木俊英 (Joint work)丸善株式会社 2005
• Methods in Molecular Biology

  Dana R. Crawford; Toshihide Suzuki; Jan Sesay; Kelvin J.A. Davies (Joint workAnalysis of gene expression following oxidative stress.)Humana Press 2002 pp. 155-162
• Antioxidant and Redox Regulation of Genes

  Dana R. Crawford; Toshihide Suzuki; Kelvin J.A. Davies (Joint workRedox Regulation of gene expression)Academic press 2000 pp. 21-45
• 活性酸素と医食同源

  鈴木俊英; 宮澤陽夫 (Joint work食物とビタミンE)共立出版株式会社 1996 pp. 188-194
• 活性酸素と栄養

  鈴木俊英; 宮澤陽夫 (Joint work活性酸素の生体物質への反応)光生館 1995 pp. 91-140
• Methods in Enzymology (Oxygen Radicals in Biological Systems Part C), Vol 233

  Teruo Miyazawa; Kenshiro Fujimoto; Toshihide Suzuki; Keiichi Yasuda (Joint workDetermination of phospholipid hydroperoxides using luminol chemiluminescence-high performance liquid chromatography)Academic Press 1994 pp. 324-332

MISC

• 認知症者における老化赤血球の出現と食品キサントフィルの効能

  宮澤 大樹; 喜古 健敬; 仲川 清隆; 荒井 啓行; 鈴木 俊英; 宮澤 陽夫  ビタミン  85-  (4)  235  -235  2011/04
• 血液脳関門におけるカチオン性薬物トランスポーターの機能および輸送分子の解析

  出口芳春; 黄倉崇; 服部麻美; 鈴木俊英; 寺崎哲也  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan  67-  2007/05
• Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: a dual mechanism approach.

  Takahiro Eitsuka; Kiyotaka Nakagawa; Toshihide Suzuki; Teruo Miyazawa  Biochimica et biophysica acta  1737-  (1)  1  -10  2005/10
• オーロラＢはがん細胞の増殖に関与する？

  鈴木俊英  ファルマシア  41-  792  -793  2005  [Invited]
  
• A trivalent dimethylarsenic compound, dimetrylarsine iodide, induces cellular transformation, aneuploidy, centrosome abnormality and multipolar spindle formation in Syrian hamster embryo cells

  T Ochi; T Suzuki; H Isono; T Tsutsui  TOXICOLOGY AND APPLIED PHARMACOLOGY  197-  (3)  202  -202  2004/06
• The genetic basis of mammalian resistance to oxidative stress

  T Suzuki; DR Spitz; P Gandhi; DR Crawford  FREE RADICAL BIOLOGY AND MEDICINE  31-  S52  -S52  2001
• 細胞の酸化ストレス耐性獲得と遺伝子発現

  鈴木俊英  化学と生物  39-  (5)  283  -285  2001  [Invited]
  
• Ganglioside as a determinant of cell fate : Regulation of cell cycle and induction of terminal differentiation and apoptosis by a particular ganglioside in human cancer cells

  NOJIRI Hisao; SUZUKI Toshihide; ISONO Hideo  日本分子生物学会年会プログラム・講演要旨集  21-  577  -577  1998/12
• オゾン層を破壊する臭化メチルの生成要因

  鈴木俊英  ファルマシア  32-  435  -436  1996  [Invited]
  
• Evaluation of Interaction of Paraquat with Lecithin or Casein by Paramecium

  ISONO H.; SASAKI HARUYO; SUZUKI TOSHIHIDE  Journal of health science  40-  (2)  p132  -139  1994/04
• DETERMINATION OF PHOSPHOLIPID HYDROPEROXIDES USING LUMINOL CHEMILUMINESCENCE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

  T MIYAZAWA; K FUJIMOTO; T SUZUKI; K YASUDA  OXYGEN RADICALS IN BIOLOGICAL SYSTEMS, PT C  233-  324  -332  1994
• フラボノイド

  鈴木俊英; 宮澤陽夫  活性酸素・フリーラジカル  2-  (2)  239  -245  1991

Research Grants & Projects

• ヒ素化合物によるヒストン修飾の多様性とその意義の解明

  文部科学省：科学研究費補助金 基盤研究(C)

  Date (from‐to) : 2011/04 

  Author : 鈴木俊英
• 酸化ストレス耐性獲得に関与する遺伝子の検索とその作用機序の解明

  文部科学省：科学研究費補助金 基盤研究(C)

  Date (from‐to) : 2004/04 -2006/03 

  Author : 鈴木俊英
• 農薬類の細胞毒性発現への細胞膜リン脂質過酸化の関与について

  文部科学省：科学研究費補助金 奨励研究(A)

  Date (from‐to) : 1996/04 -1997/03 

  Author : 鈴木俊英