Aoyama Koji

Researcher Information

Affiliation

Preclinical Medicine Professor
Department of Pharmacology Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201301074152576786

J-Global ID

• 201301074152576786

Research Interests

• アルツハイマー病   グルタチオン   EAAC1   GTRAP3-18   神経変性疾患   MPTP   パーキンソン病   EAAT3   遺伝子破壊マウス   酸化ストレス抵抗性   神経細胞   システイン   遺伝子改変マウス   

Research Areas

• Life sciences / Pharmacology
• Life sciences / Neuroscience - general

Academic & Professional Experience

• 2018/04 - Today  Teikyo UniversitySchool of MedicineProfessor
• 2013/01  Teikyo UniversitySchool of MedicineAssociate Professor
• 2005/09  Teikyo UniversitySchool of MedicineAssistant Professor
• 2002/03 - 2005/08  University of California at San FranciscoVA Medical Center, Department of NeurologyPostdoctoral fellow
• 1995  Shimane Medical University

Education

•        - 2002/03  Shimane Medical University
•        - 1995/03  Shimane Medical University

Association Memberships

• 日本生理学会   THE JAPANESE PHARMACOLOGICAL SOCIETY   JAPANESE SOCIETY OF NEUROLOGY   THE JAPANESE SOCIETY OF INTERNAL MEDICINE   

Research Activity Information

Published Papers

• A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis.

  Nobuko Matsumura; Chisato Kinoshita; Wattanaporn Bhadhprasit; Toshio Nakaki; Koji Aoyama

  Journal of pharmacological sciences 151 (1) 37 - 45 2023/01
• Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review.

  Chisato Kinoshita; Noriko Kubota; Koji Aoyama

  International journal of molecular sciences 23 (23) 2022/12
• Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases

  Chisato Kinoshita; Noriko Kubota; Koji Aoyama

  International Journal of Molecular Sciences 2021/05 [Refereed][Invited]
  
• The development of miR-96-5p gene knock out technique by CRISPR/Cas9 system

  Matsumura Nobuko; Kinoshita Chisato; Nakaki Toshio; Aoyama Koji

  Proceedings for Annual Meeting of The Japanese Pharmacological Society Japanese Pharmacological Society 94 (0) 3 - P1-37 2021
• Increased glutathione via NOVA1 by administration of an inhibitor of the microRNA miR-96-5p

  Kinoshita Chisato; Matsumura Nobuko; Aoyama Koji; Nakaki Toshio

  Proceedings for Annual Meeting of The Japanese Pharmacological Society Japanese Pharmacological Society 94 (0) 1 - P1-34 2021
• [Mechanism of glutathione production in neurons].

  Nobuko Matsumura; Chisato Kinoshita; Koji Aoyama

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 156 (1) 26 - 30 2021
• Glutathione in the brain.

  Aoyama K

  International Journal of Molecular Sciences 22 5010  2021 [Refereed][Invited]
  
• The role of non-coding RNAs in the neuroprotective effects of glutathione.

  Kinoshita C; Aoyama K

  International Journal of Molecular Sciences 22 4245  2021 [Refereed]
  
• Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression.

  Kinoshita C; Kikuchi-Utsumi K; Aoyama K; Suzuki R; Okamoto Y; Matsumura N; Omata D; Maruyama K; Nakaki T

  Communications Biology 4 182  2021 [Refereed]
  
• 特集：中枢神経におけるGSH産生促進を介する神経保護機構

  青山 晃治

  日本薬理学会誌 (公社)日本薬理学会 156 (1) 13 - 25 0015-5691 2021
• 神経細胞におけるグルタチオン産生調節機構

  松村 暢子; 木下 千智; 青山 晃治

  日本薬理学会誌 (公社)日本薬理学会 156 (1) 26 - 30 0015-5691 2021
• Increased GTRAP3-18 expression by miR-96-5p is mediated by a RNA-binding protein

  Kinoshita Chisato; Kikuchi-Utsumi Kazue; Matsumura Nobuko; Nakaki Toshio; Aoyama Koji

  Proceedings for Annual Meeting of The Japanese Pharmacological Society Japanese Pharmacological Society 93 (0) 2 - P-185 2020
• MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities. Sleep Disorders and Neurodegenerative Diseases.

  Kinoshita C; Okamoto Y; Aoyama K; Nakaki T

  Clocks & Sleep 23 (3) 282 - 307 2020 [Refereed]
  
• Disorders of glutathione metabolism.

  Aoyama K; Kinoshita C; Nakaki T

  In: Rosenberg RN, et al., eds. The Molecular and Genetic Basis of Neurologic and Psychiatric Disease. 6th ed. Boston: Lippincott Williams & Wilkins, a Wolters Kluwer 897 - 908 2020 [Invited]
  
• 尿酸による神経保護作用の可能性

  青山 晃治

  痛風と尿酸・核酸 43 (2) 16  2019
• Course and duration of therapy with Parkinsonian drugs, and withdrawal syndromes.

  Aoyama K

  In: Riederer P, et al., eds. NeuroPsychopharmacotherapy. Springer. 2019 [Refereed][Invited]
  
• Neuroprotective effect of glutathione in the brain

  Koji Aoyama

  Teikyo Medical Journal 41 (6) 211 - 220 2018/11 [Refereed][Invited]
  
• 【神経系のトランスポーター-Up to date】トランスポーターと抗酸化作用 グルタチオン

  青山 晃治; 木下 千智; 中木 敏夫

  Clinical Neuroscience (株)中外医学社 36 (6) 739 - 741 0289-0585 2018/06
• Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs

  Chisato Kinoshita; Koji Aoyama; Toshio Nakaki

  Free Radical Biology and Medicine Elsevier Inc. 119 17 - 33 1873-4596 2018/05 [Refereed]
  
• GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin

  Koji Aoyama; Wattanaporn Bhadhprasit; Masahiko Watabe; Fan Wang; Nobuko Matsumura; Toshio Nakaki

  FASEB Journal FASEB 32 (1) 330 - 341 1530-6860 2018/01 [Refereed]
  
• Novel, Versatile Method for the Production of Pharmacologically Potent Recombinant Membrane Protein

  Oshikane Hiroyuki; Watabe Masahiko; Aoyama Koji; Nakaki Toshio

  JOURNAL OF PHARMACOLOGICAL SCIENCES JAPANESE PHARMACOLOGICAL SOC 130 (3) S182 - S182 1347-8613 2016/03 [Refereed]
  
• Construction trials for PPI-based drug screening system on neurodegenerative diseases

  Oshikane Hiroyuki; Arisaka Fumio; Watabe Masahiko; Aoyama Koji; Nakaki Toshio

  JOURNAL OF PHARMACOLOGICAL SCIENCES JAPANESE PHARMACOLOGICAL SOC 128 (3) S156 - S156 1347-8613 2015/07 [Refereed]
  
• Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1)

  Koji Aoyama; Toshio Nakaki

  MOLECULES MDPI AG 20 (5) 8742 - 8758 1420-3049 2015/05 [Refereed]
  
• microRNA as a new agent for regulating neuronal glutathione synthesis and metabolism

  Kinoshita C; Aoyama K; Nakaki T

  AIMS Molecular Science 2 (2) 124 - 143 2015/04 [Refereed][Invited]
  
• Disorders of Glutathione Metabolism

  Koji Aoyama; Toshio Nakaki

  Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition Elsevier Inc. 687 - 694 2014/11 [Refereed]
  
• Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels

  Chisato Kinoshita; Koji Aoyama; Nobuko Matsumura; Kazue Kikuchi-Utsumi; Masahiko Watabe; Toshio Nakaki

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 5 3823  2041-1723 2014/05 [Refereed]
  
• Impaired glutathione synthesis in neurodegeneration

  Koji Aoyama; Toshio Nakaki

  International Journal of Molecular Sciences 10 14 (10) 21021 - 21044 1661-6596 2013/10 [Refereed]
  
• Involvement of the alpha(1D)-adrenergic Receptor in Methamphetamine-Induced Hyperthermia and Neurotoxicity in Rats

  Kazue Kikuchi-Utsumi; Mami Ishizaka; Nobuko Matsumura; Masahiko Watabe; Koji Aoyama; Nobuyuki Sasakawa; Toshio Nakaki

  NEUROTOXICITY RESEARCH SPRINGER 24 (2) 130 - 138 1029-8428 2013/08 [Refereed]
  
• Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1)

  Koji Aoyama; Toshio Nakaki

  AMINO ACIDS SPRINGER WIEN 45 (1) 133 - 142 0939-4451 2013/07 [Refereed]
  
• Anticonvulsant action of indazole.

  Nobuko Matsumura; Kazue Kikuchi-Utsumi; Kentaro Sakamaki; Masahiko Watabe; Koji Aoyama; Toshio Nakaki

  Epilepsy research 3 104 (3) 203 - 16 0920-1211 2013/05 [Refereed]
  
• Inhibition of GTRAP3-18 May Increase Neuroprotective Glutathione (GSH) Synthesis

  Koji Aoyama; Toshio Nakaki

  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES MDPI AG 13 (9) 12017 - 12035 1661-6596 2012/09 [Refereed]
  
• Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice

  Koji Aoyama; Fan Wang; Nobuko Matsumura; Hiroshi Kiyonari; Go Shioi; Karo Tanaka; Chisato Kinoshita; Kazue Kikuchi-Utsumi; Masahiko Watabe; Toshio Nakaki

  NEUROBIOLOGY OF DISEASE ACADEMIC PRESS INC ELSEVIER SCIENCE 45 (3) 973 - 982 0969-9961 2012/03 [Refereed]
  
• Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAP3-18

  Koji Aoyama; Masahiko Watabe; Toshio Nakaki

  AMINO ACIDS SPRINGER WIEN 42 (1) 163 - 169 0939-4451 2012/01 [Refereed]
  
• CAFFEINE AND URIC ACID MEDIATE GLUTATHIONE SYNTHESIS FOR NEUROPROTECTION

  K. Aoyama; N. Matsumura; M. Watabe; F. Wang; K. Kikuchi-Utsumi; T. Nakaki

  NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD 181 206 - 215 0306-4522 2011/05 [Refereed]
  
• カフェインの神経保護作用.

  青山晃治; 中木敏夫

  帝京医学雑誌 34 271 - 277 2011 [Refereed]
  
• Regulation of neuronal glutathione level by GTRAP3-18 via EAAC1 in neurons in vitro and in vivo

  Toshio Nakaki; Koji Aoyama; Masahiko Watabe

  AMINO ACIDS SPRINGER WIEN 37 (1) 18 - 19 0939-4451 2009/07 [Refereed]
  
• Crucial role of EAAC1, a member of glutamate transporter family, in cysteine uptake and glutathione level in the brain

  Koji Aoyama; Raymond A. Swanson; Masahiko Watabe; Toshio Nakaki

  AMINO ACIDS SPRINGER WIEN 37 (1) 18 - 18 0939-4451 2009/07 [Refereed]
  
• Analysis of regulatory mechanism underlying neuronal glutathione content using primary cultured neurons

  Masahiko Watabe; Koji Aoyama; Toshio Nakaki

  JOURNAL OF PHARMACOLOGICAL SCIENCES JAPANESE PHARMACOLOGICAL SOC 109 115P - 115P 1347-8613 2009 [Refereed]
  
• Analysis of regulatory mechanism underlying mouse brain glutathione synthesis

  Koji Aoyama; Masahiko Watabe; Toshio Nakaki

  JOURNAL OF PHARMACOLOGICAL SCIENCES JAPANESE PHARMACOLOGICAL SOC 109 115P - 115P 1347-8613 2009 [Refereed]
  
• Regulation of Neuronal Glutathione Synthesis

  Koji Aoyama; Masahiko Watabe; Toshio Nakaki

  JOURNAL OF PHARMACOLOGICAL SCIENCES JAPANESE PHARMACOLOGICAL SOC 108 (3) 227 - 238 1347-8613 2008/11 [Refereed]
  
• A dominant role of GTRAP3-18 in neuronal glutathione synthesis

  Masahiko Watabe; Koji Aoyama; Toshio Nakaki

  Journal of Neuroscience 38 28 (38) 9404 - 9413 0270-6474 2008/09 [Refereed]
  
• Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction

  Koji Aoyama; Nobuko Matsumura; Masahiko Watabe; Toshio Nakaki

  EUROPEAN JOURNAL OF NEUROSCIENCE WILEY-BLACKWELL 27 (1) 20 - 30 0953-816X 2008/01 [Refereed]
  
• Oxidative stress on EAAC1 in the model of Parkinson's disease

  Koji Aoyama; Nobuko Matsurnura; Masahiko Watabe; Toshio Nakaki

  JOURNAL OF PHARMACOLOGICAL SCIENCES JAPANESE PHARMACOLOGICAL SOC 106 93P - 93P 1347-8613 2008 [Refereed]
  
• Regulation of glutathione synthesis via interaction between glutamate transport-associated protein 3-18 (GTRAP3-18) and excitatory amino acid carrier-1 (EAAC1) at plasma membrane

  Masahiko Watabe; Koji Aoyama; Toshio Nakaki

  MOLECULAR PHARMACOLOGY AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS 72 (5) 1103 - 1110 0026-895X 2007/11 [Refereed]
  
• Zinc inhibits astrocyte glutamate uptake by activation of poly(ADP-ribose) polymerase-1

  Sang Won Suh; Koji Aoyama; Conrad C. Alano; Christopher M. Anderson; Aaron M. Hamby; Raymond A. Swanson

  MOLECULAR MEDICINE FEINSTEIN INST MED RES 13 (7-8) 344 - 349 1076-1551 2007/07 [Refereed]
  
• Aging and oxidative stress in progressive supranuclear palsy

  K Aoyama; K Matsubara; S Kobayashi

  EUROPEAN JOURNAL OF NEUROLOGY BLACKWELL PUBLISHING 13 (1) 89 - 92 1351-5101 2006/01 [Refereed]
  
• Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

  K Aoyama; SW Suh; AM Hamby; JL Liu; WY Chan; YM Chen; RA Swanson

  NATURE NEUROSCIENCE NATURE PUBLISHING GROUP 9 (1) 119 - 126 1097-6256 2006/01 [Refereed]
  
• GTRAP3-18を介した細胞内グルタチオン濃度の調節機構.

  渡部正彦; 青山晃治; 中木敏夫

  帝京医学雑誌 帝京大学医学部 29 (4) 227 - 230 0387-5547 2006 [Refereed]
  
• Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury

  Y Matsumori; SM Hong; K Aoyama; Y Fan; T Kayama; RA Sheldon; ZS Vexler; DM Ferriero; PR Weinstein; JL Liu

  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM LIPPINCOTT WILLIAMS & WILKINS 25 (7) 899 - 910 0271-678X 2005/07 [Refereed]
  
• Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment

  SW Suh; K Aoyama; Y Matsumori; JL Liu; RA Swanson

  DIABETES AMER DIABETES ASSOC 54 (5) 1452 - 1458 0012-1797 2005/05 [Refereed]
  
• Acidosis causes endoplasmic reticulum stress and caspase-12-mediated astrocyte death

  K Aoyama; DM Burns; SW Suh; P Garnier; Y Matsumori; H Shiina; RA Swanson

  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM NATURE PUBLISHING GROUP 25 (3) 358 - 370 0271-678X 2005/03 [Refereed]
  
• Zinc release contributes to hypoglycemia-induced neuronal death

  SW Suh; P Garnier; K Aoyama; YM Chen; RA Swanson

  NEUROBIOLOGY OF DISEASE ACADEMIC PRESS INC ELSEVIER SCIENCE 16 (3) 538 - 545 0969-9961 2004/08 [Refereed]
  
• Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia

  SW Suh; K Aoyama; YM Chen; P Garnier; Y Matsumori; E Gum; JL Liu; RA Swanson

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 23 (33) 10681 - 10690 0270-6474 2003/11 [Refereed]
  
• Meningeal involvement of chronic myelomonocytic leukemia

  K Aoyama; H Ishikura; H Tsumura; T Watanabe; N Suyama; S Kumakura; S Kobayashi

  JOURNAL OF NEUROLOGY DR DIETRICH STEINKOPFF VERLAG 250 (8) 993 - 994 0340-5354 2003/08 [Refereed]
  
• N-methylation underlying Parkinson's disease

  K Matsubara; K Aoyama; M Suno; T Awaya

  NEUROTOXICOLOGY AND TERATOLOGY PERGAMON-ELSEVIER SCIENCE LTD 24 (5) 593 - 598 0892-0362 2002/09 [Refereed]
  
• Beta-carbolines and N-methylation underlying Parkinson’s disease.

  Matsubara K; Aoyama K

  In: Nagatsu T, Nabeshima T, McCarty R, Goldstein DS, eds. Catecholamine Research: From Molecular Insights to Clinical Medicine. Advances in Behavioral Biology, London: Kluwer Academic/Plenum Publishers KLUWER ACADEMIC/PLENUM PUBL 53 459 - 462 0099-9962 2002 [Refereed]
  
• Carrier-mediated processes in blood-brain barrier penetration and neural uptake of paraquat

  K Shimizu; K Ohtaki; K Matsubara; K Aoyama; T Uezono; O Saito; M Suno; K Ogawa; N Hayase; K Kimura; H Shiono

  BRAIN RESEARCH ELSEVIER SCIENCE BV 906 (1-2) 135 - 142 0006-8993 2001/07 [Refereed]
  
• Carrier-mediated processes in blood-brain barrier penetration and neural uptake of paraquat

  K Shimizu; K Ohtaki; K Matsubara; K Aoyama; T Uezono; O Saito; M Suno; K Ogawa; N Hayase; K Kimura; H Shiono

  BRAIN RESEARCH ELSEVIER SCIENCE BV 906 (1-2) 135 - 142 0006-8993 2001/07 [Refereed]
  
• Guillain-Barre syndrome complicated with hemolytic anemia in association with antiganglioside GM3 antibody

  K Aoyama; H Ishikura; S Mishima; M Murai; H Tsumura; S Kumakura; S Kobayashi

  AMERICAN JOURNAL OF MEDICINE EXCERPTA MEDICA INC 110 (5) 399 - 400 0002-9343 2001/04 [Refereed]
  
• Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease

  K Aoyama; K Matsubara; M Kondo; Y Murakawa; M Suno; K Yamashita; S Yamaguchi; S Kobayashi

  NEUROSCIENCE LETTERS ELSEVIER IRELAND LTD 298 (1) 78 - 80 0304-3940 2001/01 [Refereed]
  
• Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases

  K Aoyama; K Matsubara; Y Fujikawa; Y Nagahiro; K Shimizu; N Umegae; N Hayase; H Shiono; S Kobayashi

  ANNALS OF NEUROLOGY LIPPINCOTT WILLIAMS & WILKINS 47 (4) 524 - 527 0364-5134 2000/04 [Refereed]
  
• N-methylation ability for azaheterocyclic amines is higher in Parkinson's disease: nicotinamide loading test

  K Aoyama; K Matsubara; K Okada; S Fukushima; K Shimizu; S Yamaguchi; T Uezono; M Satomi; N Hayase; S Ohta; H Shiono; S Kobayashi

  JOURNAL OF NEURAL TRANSMISSION SPRINGER-VERLAG WIEN 107 (8-9) 985 - 995 0300-9564 2000 [Refereed]
  
• Relationship between silent brain infarction， periventricular hyperintensity and blood pressure.

  Yamashita K; Kobayashi S; Iijima K; Aoyama K; Watanabe Y; Yamaguchi S

  Japanese journal of Stroke The Japan Stroke Society 22 (4) 585 - 589 0912-0726 2000 [Refereed]
  
• A case of cyclosporin responsive myasthenia gravis with an invasive thymoma

  Koji Aoyama; Nobuyuki Umegae; Kazuo Takahashi; Youko Murakawa; Kazunori Okada; Shotai Kobayashi

  Clinical Neurology 38 (5) 465 - 467 0009-918X 1998/05 [Refereed]
  
• Influence of apathy and depressive state on the cognitive functions of stroke patients.

  Aoyama K; Kobayashi S; Okada K; Bokura H; Yamaguchi S

  Japanese Journal of Stroke 20 (2) 239 - 243 1998 [Refereed]
  

Books etc

• Course and duration of therapy with Parkinsonian drugs, and withdrawal syndromes. In: Riederer P, et al., eds. NeuroPsychopharmacotherapy.

  Koji Aoyama (Contributor)Springer 2019/11
• eReview薬理学

  青山晃治 (Contributor)エルゼビア・ジャパン 2019
• Clinical Neuroscience

  Koji Aoyama; Chisato Kinoshita; Toshio Nakaki (Joint workGlutathione)中外医学社 2018/06
• Lippincott Illustrated Reviews Pharmacology

  Koji Aoyama (Joint translation化学療法薬 タンパク質合成阻害薬)丸善出版 2016/12
• 集中講義 薬理学

  青山晃治 (Contributor中枢神経作用薬)株式会社メジカルビュー社 2015/02
• Disorders of glutathione metabolism. In: Rosenberg RN, et al., eds. The Molecular and Genetic Basis of Neurologic and Psychiatric Disease. 5th ed. Boston: Lippincott Williams & Wilkins, a Wolters Kluwer

  Koji Aoyama; Toshio Nakaki 2014/11
• Beta-carbolines and N-methylation underlying Parkinson’s disease. In: Nagatsu T, Nabeshima T, McCarty R, Goldstein DS, eds. Catecholamine Research: From Molecular Insights to Clinical Medicine. Advances in Behavioral Biology

  Kazuo Matsubara; Koji Aoyama Kluwer Academic/Plenum Publishers 2002

MISC

• 日内リズムを呈するmicroRNAによる神経グルタチオンの制御メカニズム

  木下千智; 中木敏夫; 青山晃治  日本分子生物学会年会プログラム・要旨集(Web)  42nd-  2019
• Structure-dependent action of caffeine derivatives on cysteine uptake in mouse hippocampus slice

  Matsumura Nobuko; Aoyama Koji; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  133-  (3)  S175  -S175  2017/03  [Refereed]
  
• Effects of caffeine metabolites on the ability of cysteine uptake in brain slice

  Matsumura Nobuko; Aoyama Koji; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  130-  (3)  S193  -S193  2016/03  [Refereed]
  
• Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels

  Kinoshita Chisato; Aoyama Koji; Matsumura Nobuko; Kikuchi-Utsumi Kazue; Watabe Masahiko; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  128-  (3)  S87  -S87  2015/07  [Refereed]
  
• Feeding behavior in mice influences glutathione synthesis in the hippocampus

  Koji Aoyama; Wattanaporn Sumida; Hiroyuki Oshikane; Toshio Nakaki  JOURNAL OF PHARMACOLOGICAL SCIENCES  124-  122P  -122P  2014
• Effects of alpha 1-adrenergic receptor antagonists on methamphetamine-induced dopaminergic neurotoxicity in rats

  Kikuchi-Utsumi Kazue; Ishizaka Mami; Matsumura Nobuko; Watabe Masahiko; Aoyama Koji; Sasakawa Nobuyuki; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  121-  221P  -221P  2013  [Refereed]
  
• A behavioral study of learning and memory function in GTRAP3-18-deficient mice

  Aoyama Koji; Wang Fan; Matsumura Nobuko; Kiyonari Hiroshi; Shioi Go; Tanaka Karo; Kinoshita Chisato; Kikuchi-Utsumi Kazue; Watabe Masahiko; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  121-  122P  2013  [Refereed]
  
• ラットのメタンフェタミン誘発性ドパミン神経毒性におけるα１アドレナリン受容体拮抗薬の効果

  内海計; 石坂真美; 松村暢子; 渡部正彦; 青山晃治; 笹川展幸; 中木敏夫  日本薬理学会大会プログラム・要旨集  2013
• GTRAP3-18欠損マウスにおける記憶学習能力の行動学的解析

  青山晃治; 王凡; 松村暢子; 清成寛; 塩井剛; 田中かろ; 木下千智; 内海計; 渡部正彦; 中木敏夫  日本薬理学会大会プログラム・要旨集  2013
• ラットにおけるメタンフェタミン神経毒性へのα1Dアドレナリン受容体の関与

  内海計; 石坂真美; 松村暢子; 渡部正彦; 青山晃治; 笹川展幸; 中木敏夫  日本薬理学会北部会プログラム・抄録集  63rd-  38  2012
• ラット線条体おけるα1Dアドレナリン受容体を介したメタンフェタミン神経毒性

  内海計; 石坂真美; 松村暢子; 渡部正彦; 青山晃治; 笹川展幸; 中木敏夫  日本薬理学会関東部会口演要旨集  127th-  35  2012
• Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in rats: involvement of alpha 1D-adrenergic receptor

  Kikuchi-Utsumi Kazue; Ishizaka Mami; Matsumura Nobuko; Watabe Masahiko; Aoyama Koji; Sasakawa Nobuyuki; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  118-  144P  -144P  2012  [Refereed]
  
• A study of glutathione synthesis in GTRAP3-18-deficient mice

  Aoyama Koji; Wang Fan; Matsumura Nobuko; Kiyonari Hiroshi; Shioi Go; Tanaka Karo; Kinoshita Chisato; Utsumi Kazue; Watabe Masahiko; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  118-  103P  2012  [Refereed]
  
• ラット線条体のメタンフェタミン誘発性神経毒性におけるα1Dアドレナリン受容体の関与

  内海計; 石坂真美; 松村暢子; 渡部正彦; 青山晃治; 笹川展幸; 中木敏夫  日本薬理学会関東部会口演要旨集  124th-  (4)  51  -5P  2011/10
• EAAC1-mediated neuronal glutathione synthesis

  Koji Aoyama  AMINO ACIDS  41-  S79  -S79  2011/07
• Involvement of alpha 1D-adrenergic receptors in the neurotoxicity induced by methamphetamine in rats

  Kikuchi-Utsumi Kazue; Ishizaka Mami; Matsumura Nobuko; Watabe Masahiko; Aoyama Koji; Sasakawa Nobuyuki; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  115-  191P  -191P  2011  [Refereed]
  
• A study of glutathione synthesis induced by purine derivatives in the mouse brain

  Aoyama Koji; Matsumura Nobuko; Watabe Masahiko; Wang Fan; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  115-  77P  -77P  2011  [Refereed]
  
• インダゾールの抗痙攣作用機序に関するアイソボログラム解析

  松村暢子; 内海計; 青山晃治; 中木敏夫  日本薬理学会大会プログラム・要旨集  2011
• GTRAP3‐18阻害による神経細胞グルタチオン増加

  青山晃治; 渡部正彦; 木下千智; 松村暢子; 内海計; 中木敏夫  日本薬理学雑誌  135-  (1)  9P  -9P  2010/01
• Characterization of indazole effects on dopamine metabolism in mouse brain

  Matsumura Nobuko; Kikuchi-Utsumi Kazue; Watabe Masahiko; Aoyama Koji; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  112-  183P  -183P  2010  [Refereed]
  
• A study of cysteine uptake induced by purine derivatives in the mouse brain

  Aoyama Koji; Matsumura Nobuko; Watabe Masahiko; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  112-  83P  -83P  2010  [Refereed]
  
• マウス脳組織を用いたプリン誘導体によるシステイン取り込みに関する研究

  青山晃治; 松村暢子; 渡部正彦; 中木敏夫  日本薬理学会大会プログラム・要旨集  2010
• GTRAP3‐18阻害による神経細胞グルタチオン増加

  青山晃治; 渡部正彦; 飯高千智; 松村暢子; 内海計; 中木敏夫  日本薬理学会関東部会口演要旨集  121st-  26  2009
• Anticonvulsant property of indazole

  Nobuko Matsumura; Kazue Kikuchi-Utsumi; Koji Aoyama; Toshio Nakaki  JOURNAL OF PHARMACOLOGICAL SCIENCES  109-  194P  -194P  2009  [Refereed]
  
• インダゾールの抗痙攣作用

  松村暢子; 内海計; 青山晃治; 中木敏夫  日本薬理学会大会プログラム・要旨集  2009
• SaposinD欠損多飲マウスの病態解析―飲水制限によって劇的に改善される運動障害

  久樹晴美; 只野(有冨)桂子; 青山晃治; 松村暢子; 中木敏夫; 内田俊也; 松田純子; 岡崎具樹  生化学  3P-1193  2008
• パーキンソン病モデルにおけるEAAC1の酸化ストレス障害

  青山晃治; 松村暢子; 渡部正彦; 中木敏夫  日本薬理学会大会プログラム・要旨集  2008
• Oxidative Stress on EAAC1 involved in MPTP-induced glutathione depletion and motor deficit.

  Aoyama K; Matsumura N; Watabe M; Nakaki T  Society for Neuroscience Meeting  2007/11
• Dysfunction of EAAC1 in MPTP-induced mouse model of Parkinson's disease.

  Aoyama Koji; Matsumura Nobuko; Watabe Masahiko; Nakaki Toshio  JOURNAL OF PHARMACOLOGICAL SCIENCES  103-  87P  2007  [Refereed]
  
• マウスMPTPパーキンソン病モデルにおけるグルタミン酸トランスポーターEAAC1の機能障害

  青山晃治; 松村暢子; 渡部正彦; 中木敏夫  日本薬理学会大会プログラム・要旨集  2007
• Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

  K Aoyama; SW Suh; AM Hamby; YM Chen; RA Swanson; T Nakaki  JOURNAL OF PHARMACOLOGICAL SCIENCES  100-  97P  -97P  2006
• パーキンソン病発症と関連する感受性遺伝子変異の検索

  須野 学; 松原 和夫; 箭原 修; 青山 晃治; 小林 祥泰; 粟屋 敏雄; 山田 武宏; 藤丸 サヤカ; 田崎 嘉一  日本薬学会年会要旨集  125年会-  (2)  87  -87  2005/03
• Neuronal death and cognitive impairment caused by severe hypoglycemia can be prevented by delayed administration of poly(ADP-ribose) polymerase inhibitors

  RA Swanson; SW Suh; K Aoyama; JL Liu; YM Chen; P Garnier  ANNALS OF NEUROLOGY  54-  (6)  847  -847  2003/12
• Detection of Nicotinamide N-methyltransferase (NNMT) 5' franking region (-228A/T) polymorphism based on the polymerase chain reaction in 187 non-parkinsonian Japanese

  SUNO Manabu; AWAYA Toshio; OHTAKI Ko-ichi; MASTUBARA Kazuo; AOYAMA Koji  DNA多型 = DNA polymorphism  11-  209  -211  2003/06
• 海馬神経細胞のシステイン取り込み機構におけるカフェイン代謝物の作用

  松村 暢子; 木下 千智; 内海 計; 中木 敏夫; 青山 晃治  日本薬理学会大会プログラム・要旨集 2019年

Industrial Property Rights

• 特願2020-128453:miR-96-5pインヒビターとそれを含有する医薬組成物  2020年/07/29

  中木 敏夫, 青山 晃治, 木下 千智, 松村 暢子, 内海 計, 杉山 亨, 森谷 俊介
• 特許第4785919号:グルタチオン増加物質のスクリーニング方法  2011/07/22

  中木 敏夫, 渡部 正彦, 青山 晃治  学校法人帝京大学  201303017525175497
• WO2007-129598:グルタチオン増加物質のスクリーニング方法  2007/11/15

  中木 敏夫, 渡部 正彦, 青山 晃治  学校法人帝京大学  200903081176580343

Awards & Honors

• 2019/03 35th International Symposium on Microscale Separations and Bioanalysis. Oregon State University, USA. Award of Excellence for an outstanding poster presentation.
   Measurement of neuronal glutathione levels in the brain. USA international_society 

  受賞者: Koji Aoyama

Research Grants & Projects

• Analysis of novel peptide nucleic acids against neurodegeneration

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2023/04 -2026/03 

  Author : 青山 晃治; 木下 千智; 松村 暢子; 杉山 亨
• マイクロバブル超音波法を用いた核酸薬経鼻投与による神経変性疾患の新規治療戦略

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2021/04 -2024/03 

  Author : 木下 千智; 青山 晃治; 鈴木 亮; 松村 暢子
• プリン体および尿酸の骨髄幹細胞活性に与える影響

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2020/04 -2023/03 

  Author : 松村 暢子; 青山 晃治; 木下 千智
• 核酸薬を用いた肥満・高血糖を伴う認知機能低下に対する治療戦略

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2020/04 -2023/03 

  Author : 青山 晃治
• グルタチオン産生促進物質の経鼻投与による神経変性疾患治療法の開発

  文部科学省：科学研究費補助金(基盤研究(C))

  Date (from‐to) : 2016/04 -2020/03 

  Author : 青山晃治
• micro RNA as the master key for protection of oxidative stress

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2015/04 -2018/03 

  Author : Nakaki Toshio
• A study on mice with hypoglycemia and high cognitive ability

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012 -2014 

  Author : Nakaki Toshio; AOYAMA Koji
• Loss of the gene for a neuronal glutamate transporter-binding protein induces glutathione synthesis and better cognitive performances in mice.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011 -2013 

  Author : AOYAMA KOJI
• A study on CNS oxidative stress-resistant mouse

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(基盤研究(C))

  Date (from‐to) : 2009 -2011 

  Author : Toshio NAKAKI; Koji AOYAMA
• A novel mechanism of glutathione synthesis in neuron

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(基盤研究(C))

  Date (from‐to) : 2008 -2010 

  Author : Koji AOYAMA
• パーキンソン病動物モデルにおける神経型グルタミン酸トランスポーターの役割

  文部科学省：科学研究費補助金(若手研究(B))

  Date (from‐to) : 2006 -2007 

  Author : 青山 晃治