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Ono Takae

    Preclinical Medicine Associate Professor
    Department of Physiology Associate Professor
Last Updated :2026/09/05

Researcher Information

Affiliation

    Preclinical Medicine Associate Professor
    Department of Physiology Associate Professor
    Graduate School of Medicine Associate Professor

URL

J-Global ID

Research Interests

  • red nucleus   rubro-olivary pathway   rubro-thalamic pathway   corticorubal synapse   tissue clearing   retrograde synaptic transfer   optogenetics   corticospinal synapse   GluN2B   GliN2A   spinal motoneuron   whole cell recording   synaptic plasticity   live imaging   LTP   synapse elimination   knockout mice   LTD   

Research Areas

  • Life sciences / Neuroscience - general

Academic & Professional Experience

  • 2017/04 - Today  Teikyo UniversitySchool of Medicine

Association Memberships

  • 日本神経心理学会   THE PHYSIOLOGICAL SOCIETY OF JAPAN   THE JAPAN NEUROSCIENCE SOCIETY   日本神経内科学会   THE JAPANESE SOCIETY OF INTERNAL MEDICINE   Society for Neuroscience   

Research Activity Information

Published Papers

Books etc

  • ブレインサイエンス・レビュー2013
    大野孝恵 (Joint work皮質脊髄路シナプス除去の分子メカニズ)2013/03

Conference Activities & Talks

  • Developmental synapse elimination in cortico-motoneuronal synapse
    Takae Ohno
    The 44th Annual Meeting of the Japan Neuroscience Society, Kobe  2121/07
  • Red nucleus and its neuronal networks
    Takae Ohno
    Neuroscience 2025, San Diego  2025/11
  • The red nucleus and its networks
    Takae Ohno
    The 48th Annual Meeting of the Japan Neuroscience Society, Niigata
  • The red nucleus and its networks
    Takae Ohno
    Neuroscience 2024, Chicago
  • The red nucleus and its circuit network: cell identification through a target-selective approach utilizing retrograde vectors
    Takae Ohno
    Neuroscinece 2023, Washington, D.C.
  • The red nucleus and its networks: a selective approach to the target cells using retrograde vectors
    Takae Ohno
    The 46th Annual Meeting of the Japan Neuroscience Society, Sendai  2023/08
  • New approach of cell types and their networks of red nucleus
    Takae Ohno
    The 100th Annual Meeting of the Physiological Society of Japan, Kyoto  2023/03
  • The elimination of cortico-motoneuronal synapses during development: involvement of GluN2B containing NMDA receptor
    Takae Ohno
    The 99th Annual Meeting of the Physiological Society of Japan, Sendai
  • Involvement of GluN2B-containing NMDA receptors in the elimination of cortico-motoneuronal synapses during development
    Takae Ohno
    Society for Neuroscience 2021, Chicago  2021/11
  • developmental regression of corticomotoneuronal direct connection in mice
    Takae Ohno
    The 43rd Annual Meeting of the Japan Neuroscience Society, Kobe  2020/07
  • Temporal profile of transient corticomotoneuronal direct connection in the rodent
    Society for Neuroscience 2012, Chicago  2019/10
  • Temporal profile of developmental change in corticomotoneuronal direct connection in rodents
    Takae Ohno
    The 41st Annual Meeting of the Japan Neuroscience Society, Kobe, Japan  2018/07
  • Manipulating “critical period” by controlling synaptic GluN2B expression
    Takae Ohno
    43th Annual Meeting of Society for Neuroscience  2013/11
  • Manipulating “critical period” by regulating the synaptic GluN2B expression
    Takae Ohno
    第36回日本神経科学大会  2013/06
  • Is it possible to manipulate the “critical period” ?
    Takae Ohno
    第35回日本神経科学大会  2012/09
  • Developmental decline of 2B subunit containing NMDA receptor is essential for closing the critical period plasticity window in mouse corticospinal synapse elimination
    Takae Ohno
    41th Annual Meeting of Society for Neuroscience  2011/11
  • Developmental shift of NMDA receptor subunits is essential for closing the critical period plasticity window in mouse corticospinal synapse elimination
    Takae Ohno
    第34回日本神経科学大会  2011/09
  • Differential effect of GluN2B KO vs. GluN2A KO in corticospinal synapse elimination during development
    Takae Ohno
    40th Annual Meeting of Society for Neuroscience  2010/11
  • Differential effect of GluN2B KO vs. GluN2A KO in corticospinal synapse elimination during development:Difference in the amount of Ca2+ entry or its downstream signaling mechanism?
    Takae Ohno
    第33回日本神経科学大会  2010
  • GluRε2 (NR2B)-containing NMDA receptors are specifically involved in the corticospinal synapse elimination during development
    Takae Ohno
    39th Annual Meeting of Society for Neuroscience, Chicago  2009/10
  • GluN2B (GluRε2) is specifically involved in the corticospinal synapse elimination during development
    Takae Ohno
    第32回日本神経科学大会  2009/09
  • GluRε2(NR2B)dependent elimination of corticospinal synapsesin mice
    Takae Ohno
    37th Annual Meeting of Society for Neuroscience, San Diego  2007/11
  • マウス皮質脊髄路におけるGluRε2(2B)依存的シナプス除去
    大野孝恵
    第30回日本神経科学大会  2007/09
  • Competitive relationship between the dorsal and ventral spinal cord in the corticospinal synapse formation
    Takae Ohno
    35th Annual Meeting of Society for Neuroscience, Washington,DC  2007
  • マウススライス共培養系における皮質脊髄シナプスの活動依存的発達
    大野孝恵
    第29回日本神経科学大会  2006/07
  • 発達期皮質脊髄路シナプス除去の臨界期はNMDA 受容体サブユニットのシフトによって説明されるか？
    大野孝恵
    第28回日本神経科学大会  2005/07
  • In vitro model of critical period during development: Corticospinal synapse elimination in slice culture.
    Takae Ohno
    Society for Neuroscience 34th Annual Meeting, San Diego  2004/10
  • 皮質脊髄路シナプス除去過程における臨界期のin vitroモデル
    大野孝恵
    第27回日本神経科学大会  2004/09
  • Developmental plasticity of corticospinal synapses in vitro: Activity-dependent synpase elimination and its critical period
    Takae Ohno
    The 6th IBRO World Congress of Neuroscience, Prague  2003/07
  • 皮質脊髄路シナプス形成におけるシナプス競合
    大野孝恵
    第26回神経科学大会  2003/07

MISC

  • The red nucleus and its circuit network: cell identification through a target-selective approach utilizing retrograde vectors
    T. Ohno; H. Miyake; N. Murabe; S. Fukuda; S. Takai; T. Yoshida; K. Nakajima; T. Hayashi  2023/11
  • The red nucleus and its networks: a selective approach to the target cells using retrograde vectors
    Takae Ohno; Satoshi Fukuda; Naoyuki Murabe; Hideo Miyake; Shu Takai; Toshihiro Hayashi  The 46th Annual Meeting of the Japan Neuroscience Society, Sendai, Japan  2023/08
  • 赤細胞群核とその回路網探究の新たな試み
    大野孝恵; 福田諭; 村部直之; 三宅英雄; 高井秀; 林俊宏  日本生理学会第100回記念大会  2023/03
  • The elimination of cortico-motoneuronal synapses during development: involvement of GluN2B containing NMDA receptor
    Ohno T; Fukuda S; Murabe N; Sakimura K; Hayashi T; Sakurai M  The 99th Annual Meeting of the Physiological Society of Japan, Sendai  2022/03
  • Involvement of GluN2B-containing NMDA receptors in the elimination of cortico-motoneuronal synapses during development
    Ohno T; Fukuda S; Murabe N; Sakimura K; Hayashi T; Sakurai M  Society for Neuroscience, Chicago  2021/11
  • Developmental synapse elimination in cortico-motoneuronal synapse
    Ohno T; Fukuda S; Hayashi T; Sakurai M  The 44ｔｈ Annual Meeting of the Japan Neuroscience Society, Kobe, Japan  2021/07
  • Developmental elimination of cortico-motoneuronal direct connection in mice
    Ohno T; Fukuda S; Hayashi T; Sakurai M  The 43rd Annual Meeting of the Japan Neuroscience Society, Kobe  2020/07
  • Temporal profile of transient corticomotoneuronal direct connection in the rodent.
    Ohno, T; Fukuda, S; Murabe, N; Mizukami, H; Ozawa, K; Hayashi, T; Sakurai, M  Society for Neuroscience  2019/10
  • Transient synapse formation and regression of direct cortico-motoneuronal synapses during development in rodents.
    Fukuda, S; Ohno, T; Murabe, N; Niido, M; Mizukami, H; Ozawa, K; Hayashi, T; Sakurai, M  The 42st Annual Meeting of the Japan Neuroscience Society  2019/07
  • Temporal profile of developmental change in corticomotoneuronal direct connection in rodents.
    Ohno, T; Fukuda, S; Niido, M; Murabe, N; Mizukami, H; Ozawa, K; Hayashi, T; Sakurai, M  The 41st Annual Meeting of the Japan Neuroscience Society  2018/07
  • Quantitative study of distal-proximal distribution of target muscles innervated by motoneurons which receive direct connections from corticospinal axons in juvenile rodent.
    Fukuda, S; Ohno, T; Niido, M; Murabe, N; Mizukami, H; Ozawa, K; Hayashi, T; Sakurai, M  The 41st Annual Meeting of the Japan Neuroscience Society  2018/07
  • Takae Ohno; Mutsumi Isowaki; Noriko Isoo; Naoyuki Murabe; Hitoshi Maeda; Satoshi Fukuda; Noboru Yoshioka; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E232  -E232  2011
  • Noriko Isoo; Takae Ohno; Naoyuki Murabe; Noboru Yoshioka; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E334  -E334  2011
  • Mutsumi Isowaki; Takae Ohno; Noriko Iso-o; Hitoshi Maeda; Satoshi Fukuda; Takakazu Kobayashi; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E133  -E133  2011
  • Takae Ohno; Hitoshi Maeda; Naoyuki Murabe; Tsutomu Kamiyama; Noboru Yoshioka; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  68-  E86  -E87  2010
  • Takae Ohno; Hitoshi Maeda; Naoyuki Murabe; Tsutomu Kamiyama; Noboru Yoshioka; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  65-  S37  -S37  2009
  • Takae Ohno; Noboru Yoshioka; Hitoshi Maeda; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  58-  S50  -S50  2007
  • Noboru Yoshioka; Takae Ohno; Masaki Sakurai  NEUROSCIENCE RESEARCH  58-  S144  -S144  2007
  • Takae Ohno; Masaki Sakurai  NEUROSCIENCE RESEARCH  55-  S61  -S61  2006
  • 皮質脊髄路シナプスにおける活動依存性除去には臨界期が存在する
    大野 孝恵; 辻 省次; 桜井 正樹  臨床神経学  43-  (12)  966  -966  2003/12
  • 左視床梗塞にて失行性失書を呈した1例
    大野 孝恵; 板東 充秋; 名倉 博史; 山之内 博; 石井 賢二  神経心理学  15-  (4)  269  -269  1999/12
  • 左視床梗塞にて失行性失書を呈した1例
    大野 孝恵; 板東 充秋; 名倉 博史; 山之内 博; 石井 賢二  臨床神経学  39-  (8)  887  -887  1999/08

Awards & Honors

  • 2019/06 第５回(平成31年度)基礎医学研究助成 渡辺慶子賞
     発達期マウスにおける一過性皮質脊髄運動ニューロン直接結合：その除去メカニズムと個体・系統発生的意義 
    受賞者: 大野孝恵
  • 2011/09 第34回日本神経科学学会 第25回ブレインサイエンス振興財団研究助成
     皮質脊髄路シナプス除去の分子メカニズム 
    受賞者: 大野孝恵

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2026/06 -2028/03 
    Author : 大野 孝恵; 福田 諭; 林 俊宏; 加藤 成樹; 渡邉 貴樹; 吉田 崇将
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2025/03 
    Author : 福田 諭; 大野 孝恵
  • 日本学術振興会：科学研究費助成事業 基盤研究(C)
    Date (from‐to) : 2022/04 -2025/03 
    Author : 大野 孝恵; 福田諭
  • 発達に伴う皮質運動ニューロン連関の可塑性変化-運動ニューロンは学習するのか？-
    科学研究費：基盤研究(Ｃ)
    Date (from‐to) : 2018/04 -2022/03 
    Author : 大野孝恵; 福田諭
  • 発達期マウスにおける一過性皮質脊髄運動ニューロン直接結：その除去メカニズムと個体・系統発生的意義
    基礎医学研究助成 渡辺慶子賞
    Date (from‐to) : 2020/04 -2021/03
  • in vitroスライス培養系におけるシナプス除去とその分子メカニズム
    科学研究費：基盤研究(Ｃ)
    Date (from‐to) : 2010/04 -2013/03 
    Author : 大野孝恵
  • 皮質脊髄路シナプス除去の分子メカニズム
    ブレインサイエンス振興財団：研究助成金
    Date (from‐to) : 2011/04 -2012/03 
    Author : 大野孝恵
  • 発達期皮質脊髄路シナプスの活動依存的除去とNMDA受容体サブタイプ
    科学研究費：若手研究(スタートアップ)
    Date (from‐to) : 2008/04 -2011/03 
    Author : 大野孝恵
  • 皮質脊髄路シナプスの発達と可塑性
    科学研究費：特別研究員奨励費
    Date (from‐to) : 2005/04 -2008/03 
    Author : 大野孝恵
  • 皮質脊髄路シナプスの発達と可塑性
    中島記念国際交流財団：日本人若手研究者助成金
    Date (from‐to) : 2005/04 -2006/03 
    Author : 大野孝恵

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