Adachi Mimi

Researcher Information

Affiliation

Preclinical Medicine Professor and Chairman
Department of Biochemistry Professor and Chairman
Graduate School of Medicine Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201301002467394200

J-Global ID

• 201301002467394200

Research Interests

• cyclin D1   epigenetics   cellular senescence   aging   細胞増殖   サイクリンD1   心筋細胞   p27   増殖   ユビキチン化   p27^   miRNA   ヘテロクロマチン   核移行   老化   CDK   心筋再生   skp2   サイクリン   細胞周期   ヒストン   siRNA   p27kip1   TGFβ   細胞死   転写仲介因子   クロマチン構造   p300遺伝子   口腔癌   ブロモドメイン   癌抑制遺伝子   

Research Areas

• Life sciences / Cell biology
• Life sciences / Molecular biology
• Life sciences / Medical biochemistry / regeneration
• Life sciences / Metabolism and endocrinology
• Life sciences / Cardiology
• Life sciences / Medical biochemistry / 加齢医学

Academic & Professional Experience

• 2020/04 - Today  Teikyo University School of MedicineDepartment of BiochemistryProfessor
• 2018/12 - Today  Teikyo UniversitySchool of Medicine
• 2013/04 - 2018/11  Teikyo University School of MedicineDepartment of BiochemistryAssociate Professor
• 2013/04 - 2018/11  Teikyo UniversitySchool of Medicine
• 2010/04 - 2013/03  Teikyo University School of MedicineDepartment of BiochemistryLecturer
• 2010/04 - 2013/03  Teikyo UniversitySchool of Medicine
• 2009/01 - 2010/03  Brown UniversityDepartment of Molecular Biology, Cell Biology and Biochemistry Laboratories for Molecular MedicineVisiting Scientist
• 2007/04 - 2010/03  Tokyo Medical and Dental UniversityMedical Research Institute
• 2000/01 - 2010/03  Tokyo Medical and Dental UniversityDepartment of Biochemical Genetics, Medical Research InstituteAssistant Professor
• 2000/01 - 2007/03  Tokyo Medical and Dental UniversityMedical Research Institute
• 1997/04 - 2000/01  Grant-in-Aid for Japan Society for the Promotion of Science (JSPS)Fellow
• 1996/04 - 1997/03  Tokyo Medical and Dental Universitythe 2nd Department of Internal MedicineMedical Doctor
• 1996/04 - 1997/03  Tokyo Medical and Dental University
• 1991/06 - 1992/03  Tsuchiura General Hospitalthe Department of Internal MedicineMedical Doctor
• 1990/05 - 1991/05  Tokyo Medical and Dental Universitythe 2nd Department of Internal MedicineResident
• 1990/05 - 1991/05  Tokyo Medical and Dental University

Education

• 1992/04 - 1996/03  Tokyo Medical and Dental University  Internal Medicine  PhD.
• 1992/04 - 1996/03  Tokyo Medical and Dental University  Graduate School of Medical and Dental Sciences
• 1984/04 - 1990/03  Tokyo Medical and Dental University  M.D.
• 1984/04 - 1990/03  Tokyo Medical and Dental University  Faculty of Medicine  School of Medicine

Research Activity Information

Published Papers

• Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion.

  Noriyuki Okudaira; Mi-Ho Akimoto; Takao Susa; Miho Akimoto; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Julio A Almunia; Noboru Ogiso; Tomoki Okazaki; Mimi Tamamori-Adachi

  Aging cell e14206  2024/05 [Refereed]
  
• Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.

  Miho Akimoto; Takao Susa; Noriyuki Okudaira; Nobuko Koshikawa; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Keizo Takenaga; Tomoki Okazaki; Mimi Tamamori-Adachi

  Proceedings of the National Academy of Sciences of the United States of America 120 (18) e2218033120  2023/05 [Refereed]
  
• A Novel LncRNA PTH-AS Upregulates Interferon-Related DNA damage resistance Signature genes and Promotes Metastasis in Human Breast Cancer Xenografts.

  Miho Akimoto; Takao Susa; Noriyuki Okudaira; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Tomoki Okazaki; Mimi Tamamori-Adachi

  The Journal of biological chemistry 102065 - 102065 2022/05 [Refereed]
  
• Resveratrol blocks retrotransposition of LINE-1 through PPAR α and sirtuin-6.

  Noriyuki Okudaira; Yukihito Ishizaka; Mimi Tamamori-Adachi

  Scientific reports 12 (1) 7772 - 7772 2022/05 [Refereed]
  
• ヒト前立腺癌細胞にてDHTで抑制されるHOXC9はARの阻害因子として機能する

  諏佐 崇生; 秋元 美穂; 奥平 准之; 飯塚 眞由; 岡崎 具樹; 安達 三美

  日本内分泌学会雑誌 (一社)日本内分泌学会 98 (1) 295 - 295 0029-0661 2022/04
• 25(OH)D3 stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated.

  Takahiro Kikuyama; Takao Susa; Mimi Tamamori-Adachi; Masayoshi Iizuka; Miho Akimoto; Hiroko Okinaga; Yoshihide Fujigaki; Shunya Uchida; Shigeru Shibata; Tomoki Okazaki

  The Journal of steroid biochemistry and molecular biology 199 105593 - 105593 2020/01 [Refereed]
  
• Without 1α-hydroxylation, the gene expression profile of 25(OH)D3 treatment overlaps deeply with that of 1,25(OH)2D3 in prostate cancer cells

  Takao Susa; Masayoshi Iizuka; Hiroko Okinaga; Mimi Tamamori-Adachi; Tomoki Okazaki

  Scientific Reports Nature Publishing Group 8 (1) 9024  2045-2322 2018/12 [Refereed]
  
• DNA damage response induced by Etoposide promotes steroidogenesis via GADD45A in cultured adrenal cells.

  Tamamori-Adachi M; Koga A; Susa T; Fujii H; Tsuchiya M; Okinaga H; Hisaki H; Iizuka M; Kitajima S; Okazaki T

  Scientific reports 8 (1) 9636  2018/06 [Refereed]
  
• ヒト前立腺癌LNCaP細胞における25(OH)D3のビタミンD3活性の評価

  諏佐 崇生; 飯塚 眞由; 安達 三美; 岡崎 具樹

  日本内分泌学会雑誌 (一社)日本内分泌学会 94 (1) 369 - 369 0029-0661 2018/04
• ヒト前立腺癌LNCaP細胞において25(OH)D3は1,25(OH)2D3の標的遺伝子と類似した遺伝子群を制御する

  諏佐 崇生; 飯塚 眞由; 安達 三美; 岡崎 具樹

  生命科学系学会合同年次大会 生命科学系学会合同年次大会運営事務局 2017年度 [2P - 0434] 2017/12
• Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor alpha

  Masayoshi Iizuka; Takao Susa; Mimi Tamamori-Adachi; Hiroko Okinaga; Tomoki Okazaki

  PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 93 (7) 498 - 510 0386-2208 2017/07 [Refereed]
  
• An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.

  Kosuke Uchida; Yuji Tanaka; Hitoshi Ichikawa; Masato Watanabe; Sachiyo Mitani; Koji Morita; Hiroko Fujii; Mayumi Ishikawa; Gen Yoshino; Hiroko Okinaga; Genta Nagae; Hiroyuki Aburatani; Yoshifumi Ikeda; Takao Susa; Mimi Tamamori-Adachi; Toshio Fukusato; Hiroshi Uozaki; Tomoki Okazaki; Masayoshi Iizuka

  Journal of the Endocrine Society 1 (6) 691 - 711 2017/06 [Refereed]
  
• Wild-type and Specific Mutant Androgen Receptor Mediates Transcription via 17 beta-Estradiol in Sex Hormone-sensitive Cancer Cells

  Takao Susa; Reina Ikaga; Takashi Kajitani; Masayoshi Iizuka; Hiroko Okinaga; Mimi Tamamori-Adachi; Tomoki Okazaki

  JOURNAL OF CELLULAR PHYSIOLOGY 230 (7) 1594 - 1606 0021-9541 2015/07 [Refereed]
  
• Marked Cortisol Production by Intracrine ACTH in GIP-Treated Cultured Adrenal Cells in Which the GIP Receptor Was Exogenously Introduced

  Hiroko Fujii; Mimi Tamamori-Adachi; Kousuke Uchida; Takao Susa; Takashi Nakakura; Haruo Hagiwara; Masayoshi Iizuka; Hiroko Okinaga; Yuji Tanaka; Tomoki Okazaki

  PLOS ONE 9 (10) e110543  1932-6203 2014/10 [Refereed]
  
• Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers.

  Masayoshi Iizuka; Takao Susa; Yoshihisa Takahashi; Mimi Tamamori-Adachi; Takashi Kajitani; Hiroko Okinaga; Toshio Fukusato; Tomoki Okazaki

  Cancer science 104 (12) 1647 - 55 1347-9032 2013/12 [Refereed]
  
• Histone acetyltransferase Hbo1 destabilizes estrogen receptor a by ubiquitination and modulates proliferation of breast cancers

  Masayoshi Iizuka; Takao Susa; Yoshihisa Takahashi; Mimi Tamamori-Adachi; Takashi Kajitani; Hiroko Okinaga; Toshio Fukusato; Tomoki Okazaki

  CANCER SCIENCE 104 (12) 1647 - 1655 1349-7006 2013/12 [Refereed]
  
• Primary polydipsia, but not accumulated ceramide, causes lethal renal damage in saposin D-deficient mice

  Harumi Hisaki; Junko Matsuda; Keiko Tadano-Aritomi; Shunya Uchida; Hiroko Okinaga; Makoto Miyagawa; Mimi Tamamori-Adachi; Masayoshi Iizuka; Tomoki Okazaki

  AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 303 (7) F1049 - F1059 1931-857X 2012/10 [Refereed]
  
• Primary polydipsia, but not accumulated ceramide, causes lethal renal damage in saposin D-deficient mice

  Harumi Hisaki; Junko Matsuda; Keiko Tadano-Aritomi; Shunya Uchida; Hiroko Okinaga; Makoto Miyagawa; Mimi Tamamori-Adachi; Masayoshi Iizuka; Tomoki Okazaki

  American Journal of Physiology - Renal Physiology 303 (7) F1049 - F1059 0363-6127 2012/10 [Refereed]
  
• Degradation of p21(Cip1) through Anaphase-promoting Complex/Cyclosome and Its Activator Cdc20 (APC/C-Cdc20) Ubiquitin Ligase Complex-mediated Ubiquitylation Is Inhibited by Cyclin-dependent Kinase 2 in Cardiomyocytes

  Kazuhiko Yamada; Mimi Tamamori-Adachi; Ikuko Goto; Masayoshi Iizuka; Takashi Yasukawa; Teijiro Aso; Tomoki Okazaki; Shigetaka Kitajima

  JOURNAL OF BIOLOGICAL CHEMISTRY 286 (51) 44057 - 44066 0021-9258 2011/12 [Refereed]
  
• Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay

  Marco De Cecco; Jessie Jeyapalan; Xiaoai Zhao; Mimi Tamamori-Adachi; John M. Sedivy

  AGING-US 3 (10) 955 - 967 1945-4589 2011/10 [Refereed]
  
• Systems Analysis of ATF3 in Stress Response and Cancer Reveals Opposing Effects on Pro-Apoptotic Genes in p53 Pathway

  Yujiro Tanaka; Aya Nakamura; Masaki Suimye Morioka; Shoko Inoue; Mimi Tamamori-Adachi; Kazuhiko Yamada; Kenji Taketani; Junya Kawauchi; Miki Tanaka-Okamoto; Jun Miyoshi; Hiroshi Tanaka; Shigetaka Kitajima

  PLOS ONE 6 (10) e26848  1932-6203 2011/10 [Refereed]
  
• Negative regulation of parathyroid hormone-related protein expression by steroid hormones

  Takashi Kajitani; Mimi Tamamori-Adachi; Hiroko Okinaga; Minoru Chikamori; Masayoshi Iizuka; Tomoki Okazaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 407 (3) 472 - 478 0006-291X 2011/04 [Refereed]
  
• Age-associated increase in heterochromatic marks in murine and primate tissues

  Jill A. Kreiling; Mimi Tamamori-Adachi; Alec N. Sexton; Jessie C. Jeyapalan; Ursula Munoz-Najar; Abigail L. Peterson; Jayameenakshi Manivannan; Elizabeth S. Rogers; Nikolay A. Pchelintsev; Peter D. Adams; John M. Sedivy

  AGING CELL 10 (2) 292 - 304 1474-9718 2011/04 [Refereed]
  
• ビタミンDによる転写抑制機構のheterogeneity

  岡崎 具樹; 安達 三美; 飯塚 眞由; 梶谷 宇

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 (公社)日本生化学会 83回・33回 1P - 0341 2010/12
• Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells

  Keisuke Miyazaki; Shoko Inoue; Kazuhiko Yamada; Masashi Watanabe; Qin Liu; Toshiki Watanabe; Mimi Tamamori Adachi; Yujiro Tanaka; Shigetaka Kitajima

  NUCLEIC ACIDS RESEARCH 37 (5) 1438 - 1451 0305-1048 2009/04 [Refereed]
  
• Skp2 promotes adipocyte differentiation via a p27(Kip1)-independent mechanism in primary mouse embryonic fibroblasts

  Mitsuru Okada; Tamon Sakai; Takehiro Nakamura; Mimi Tamamori-Adachi; Shigetaka Kitajima; Yasushi Matsuki; Eijiro Watanabe; Ryuji Hiramatsu; Hiroshi Sakaue; Masato Kasuga

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379 (2) 249 - 254 0006-291X 2009/02 [Refereed]
  
• Differential regulation of cyclin D1 and D2 in protecting against cardiomyocyte proliferation

  Mimi Tamamori-Adachi; Ikuko Goto; Kazuhiko Yamada; Shigetaka Kitajima

  CELL CYCLE 7 (23) 3768 - 3774 1538-4101 2008/12 [Refereed]
  
• Distinct roles of GSK-3 alpha and GSK-3 beta phosphorylation in the heart under pressure overload

  Takahisa Matsuda; Peiyong Zhai; Yasuhiro Maejima; Chull Hong; Shumin Gao; Bin Tian; Kazumichi Goto; Hiromitsu Takagi; Mimi Tamamori-Adachi; Shigetaka Kitajima; Junichi Sadoshima

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 (52) 20900 - 20905 0027-8424 2008/12 [Refereed]
  
• Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase

  Mimi Tamamori-Adachi; Hiromitsu Takagi; Kimio Hashimoto; Kazumichi Goto; Toshinori Hidaka; Uichi Koshimizu; Kazuhiko Yamada; Ikuko Goto; Yasuhiro Maejima; Mitsuaki Isobe; Keiichi I. Nakayama; Norio Inomata; Shigetaka Kitajima

  CARDIOVASCULAR RESEARCH 80 (2) 181 - 190 0008-6363 2008/11 [Refereed]
  
• PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27(Kip1) expression

  Kyoko Nakamura; Hiroshi Sakaue; Akihiko Nishizawa; Yasushi Matsuki; Hideyuki Gomi; Eijiro Watanabe; Ryuji Hiramatsu; Mimi Tamamori-Adachi; Shigetaka Kitajima; Tetsuo Noda; Wataru Ogawa; Masato Kasuga

  JOURNAL OF BIOLOGICAL CHEMISTRY 283 (25) 17702 - 17711 0021-9258 2008/06 [Refereed]
  
• Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma

  Sin-Ae Lee; Sung-Yul Lee; Ik-Hyun Cho; Min-A Oh; Eun-Sil Kang; Yong-Bae Kim; Woo Duck Seo; Suyong Choi; Ju-Ock Nam; Mimi Tamamori-Adachi; Shigetaka Kitajima; Sang-Kyu Ye; Semi Kim; Yoon-Jin Hwang; In-San Kim; Ki Hun Park; Jung Weon Lee

  JOURNAL OF CLINICAL INVESTIGATION 118 (4) 1354 - 1366 0021-9738 2008/04 [Refereed]
  
• Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A

  K. Miyata; T. Yasukawa; M. Fukuda; T. Takeuchi; K. Yamazaki; K. Sakumi; M. Tamamori-Adachi; Y. Ohnishi; Y. Ohtsuki; Y. Nakabeppu; S. Kitajima; S. Onishi; T. Aso

  CELL DEATH AND DIFFERENTIATION 14 (4) 716 - 726 1350-9047 2007/04 [Refereed]
  
• HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1

  Kino Morikawa-Futamatsu; Susumu Adachi; Yasuhiro Maejima; Mimi Tamamori-Adachi; Jun-ichi Suzuki; Shigetaka Kitajima; Hiroshi Ito; Mitsuaki Isobe

  LIFE SCIENCES 79 (14) 1380 - 1390 0024-3205 2006/08 [Refereed]
  
• Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/6

  Yoshinori Nonomura; Kenji Nagasaka; Hiroyuki Hagiyama; Chiyoko Sekine; Toshihiro Nanki; Mimi Tamamori-Adachi; Nobuyuki Miyasaka; Hitoshi Kohsaka

  ARTHRITIS AND RHEUMATISM 54 (7) 2074 - 2083 0004-3591 2006/07 [Refereed]
  
• A splice variant of stress response gene ATF3 counteracts NF-kappa B-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator

  B Hua; M Tamamori-Adachi; Y Luo; K Tamura; M Morioka; M Fukuda; Y Tanaka; S Kitajima

  JOURNAL OF BIOLOGICAL CHEMISTRY 281 (3) 1620 - 1629 0021-9258 2006/01 [Refereed]
  
• Cyclin A-associated kinase activity is needed for paclitaxel sensitivity

  T Takahashi; F Yamasaki; T Sudo; H Itamochi; S Adachi; M Tamamori-Adachi; NT Ueno

  MOLECULAR CANCER THERAPEUTICS 4 (7) 1039 - 1046 1535-7163 2005/07 [Refereed]
  
• Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

  K Tamura; BY Hua; S Adachi; Guney, I; J Kawauchi; M Morioka; M Tamamori-Adachi; Y Tanaka; Y Nakabeppu; M Sunamori; JM Sedivy; S Kitajima

  EMBO JOURNAL 24 (14) 2590 - 2601 0261-4189 2005/07 [Refereed]
  
• Down-regulation of p27(Kip1) promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin d1 and CDK4-Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation

  M Tamamori-Adachi; K Hayashida; K Nobori; C Omizu; K Yamada; N Sakamoto; T Kamura; K Fukuda; S Ogawa; KI Nakayama; S Kitajima

  JOURNAL OF BIOLOGICAL CHEMISTRY 279 (48) 50429 - 50436 0021-9258 2004/11 [Refereed]
  
• Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons

  P Sumrejkanchanakij; M Tamamori-Adachi; Y Matsunaga; K Eto; MA Ikeda

  ONCOGENE 22 (54) 8723 - 8730 0950-9232 2003/11 [Refereed]
  
• Nitric oxide inhibits ischemia/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity

  Y Maejima; S Adachi; H Ito; K Nobori; M Tamamori-Adachi; M Isobe

  CARDIOVASCULAR RESEARCH 59 (2) 308 - 320 0008-6363 2003/08 [Refereed]
  
• Nitric oxide inhibits ischemia/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity

  Y Maejima; S Adachi; H Ito; K Nobori; M Tamamori-Adachi; M Isobe

  CARDIOVASCULAR RESEARCH 59 (2) 308 - 320 0008-6363 2003/08 [Refereed]
  
• E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53

  KW Ma; K Araki; SJA Ichwan; T Suganuma; M Tamamori-Adachi; MA Ikeda

  MOLECULAR CANCER RESEARCH 1 (6) 438 - 444 1541-7786 2003/04 [Refereed]
  
• Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation

  M Tamamori-Adachi; H Ito; P Sumrejkanchanakij; S Adachi; M Hiroe; M Shimizu; J Kawauchi; M Sunamori; F Marumo; S Kitajima; MA Ikeda

  CIRCULATION RESEARCH 92 (1) E12 - E19 0009-7330 2003/01 [Refereed]
  
• Lipopolysaccharide pretreatment attenuates myocardial infarct size: A possible mechanism involving heat shock protein 70-inhibitory kappa B alpha complex and attenuation of nuclear factor kappa B

  M Shimizu; M Tamamori-Adachi; H Arai; N Tabuchi; H Tanaka; M Sunamori

  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 124 (5) 933 - 941 0022-5223 2002/11 [Refereed]
  
• Lipopolysaccharide pretreatment attenuates myocardial infarct size: A possible mechanism involving heat shock protein 70-inhibitory kappa B alpha complex and attenuation of nuclear factor kappa B

  M Shimizu; M Tamamori-Adachi; H Arai; N Tabuchi; H Tanaka; M Sunamori

  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 124 (5) 933 - 941 0022-5223 2002/11 [Refereed]
  
• Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription

  J Kawauchi; C Zhang; K Nobori; Y Hashimoto; MT Adachi; A Noda; M Sunamori; S Kitajima

  JOURNAL OF BIOLOGICAL CHEMISTRY 277 (41) 39025 - 39034 0021-9258 2002/10 [Refereed]
  
• ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: A novel cardioprotective role of ATF3

  K Nobori; H Ito; M Tamamori-Adachi; S Adachi; Y Ono; J Kawauchi; S Kitajima; F Marumo; M Isobe

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 34 (10) 1387 - 1397 0022-2828 2002/10 [Refereed]
  
• ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: A novel cardioprotective role of ATF3

  K Nobori; H Ito; M Tamamori-Adachi; S Adachi; Y Ono; J Kawauchi; S Kitajima; F Marumo; M Isobe

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 34 (10) 1387 - 1397 0022-2828 2002/10 [Refereed]
  
• Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy

  M Tamamori-Adachi; H Ito; K Nobori; K Hayashida; J Kawauchi; S Adachi; MA Ikeda; S Kitajima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 296 (2) 274 - 280 0006-291X 2002/08 [Refereed]
  
• An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli

  Y Hashimoto; C Zhang; J Kawauchi; Imoto, I; MT Adachi; J Inazawa; T Amagasa; T Hai; S Kitajima

  NUCLEIC ACIDS RESEARCH 30 (11) 2398 - 2406 0305-1048 2002/06 [Refereed]
  
• Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: colocalization and possible involvement in cell death of vascular endothelial cells

  T Nawa; MT Nawa; MT Adachi; Uchimura, I; R Shimokawa; K Fujisawa; A Tanaka; F Numano; S Kitajima

  ATHEROSCLEROSIS 161 (2) 281 - 291 0021-9150 2002/04 [Refereed]
  
• Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine

  C Zhang; J Kawauchi; MT Adachi; Y Hashimoto; S Oshiro; T Aso; S Kitajima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 289 (3) 718 - 724 0006-291X 2001/12 [Refereed]
  
• Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response

  C Zhang; Y Cai; MT Adachi; S Oshiro; T Aso; RJ Kaufman; S Kitajima

  JOURNAL OF BIOLOGICAL CHEMISTRY 276 (38) 35867 - 35874 0021-9258 2001/09 [Refereed]
  
• Cyclin A/cdk2 activation is involved in hypoxia-induced apoptosis in cardiomyocytes

  S Adachi; H Ito; M Tamamori-Adachi; Y Ono; T Nozato; S Abe; M Ikeda; F Marumo; M Hiroe

  CIRCULATION RESEARCH 88 (4) 408 - 414 0009-7330 2001/03 [Refereed]
  
• Role and relation of p70 S6 and extracellular signal-regulated kinases in the phenotypic changes of hypertrophy of cardiac myocytes

  Y Ono; H Ito; M Tamamori; T Nozato; S Adachi; S Abe; F Marumo; M Hiroe

  JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION 64 (9) 695 - 700 0047-1828 2000/09 [Refereed]
  
• Role and relation of p70 S6 and extracellular signal-regulated kinases in the phenotypic changes of hypertrophy of cardiac myocytes

  Y Ono; H Ito; M Tamamori; T Nozato; S Adachi; S Abe; F Marumo; M Hiroe

  JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION 64 (9) 695 - 700 0047-1828 2000/09 [Refereed]
  
• G1 cyclins are involved in the mechanism of cardiac myocyte hypertrophy induced by angiotensin II

  T Nozato; H Ito; M Tamamori; S Adachi; S Abe; F Marumo; M Hiroe

  JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION 64 (8) 595 - 601 0047-1828 2000/08 [Refereed]
  
• Cell cycle inhibitors (p27(Kip1) and p21(CIP1)) cause hypertrophy in LLC-PK1 cells

  Y Terada; S Inoshita; O Nakashima; M Tamamori; H Ito; M Kuwahara; S Sasaki; F Marumo

  KIDNEY INTERNATIONAL 56 (2) 494 - 501 0085-2538 1999/08 [Refereed]
  
• Thermal preconditioning protects rat cardiac muscle cells from doxorubicin-induced apoptosis

  H Ito; T Shimojo; H Fujisaki; M Tamamori; S Ishiyama; S Adachi; S Abe; F Marumo; M Hiroe

  LIFE SCIENCES 64 (9) 755 - 761 0024-3205 1999/01 [Refereed]
  
• Essential roles for G1 cyclin-dependent kinase activity in development of cardiomyocyte hypertrophy.

  Tamamori M; Ito H; Hiroe M; Terada Y; Marumo F; Ikeda MA

  The American journal of physiology 275 (6 Pt 2) H2036 - 40 0002-9513 1998/12 [Refereed]
  
• Skeletal and smooth muscle alpha-actin mRNA in endomyocardial biopsy samples of dilated cardiomyopathy patients

  S Adachi; H Ito; M Tamamori; M Tanaka; F Marumo; M Hiroe

  LIFE SCIENCES 63 (20) 1779 - 1791 0024-3205 1998/10 [Refereed]
  
• Cyclin D1, p16, and retinoblastoma gene regulate mitogenic signaling of endothelin in rat mesangial cells

  Y Terada; S Inoshita; O Nakashima; T Yamada; M Tamamori; H Ito; S Sasaki; F Marumo

  KIDNEY INTERNATIONAL 53 (1) 76 - 83 0085-2538 1998/01 [Refereed]
  
• Calcitonin gene-related peptide (CGRP) increases cell surface area and induces expression of skeletal alpha-actin and ANP mRNA in hypertrophying neonatal cardiomyocytes

  D Bell; M Tamamori; F Marumo; M Hiroe; BJ McDermott; H Ito

  REGULATORY PEPTIDES 71 (1) 1 - 7 0167-0115 1997/07 [Refereed]
  
• Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides

  M Tamamori; H Ito; M Hiroe; F Marumo; RI Hata

  CELL BIOLOGY INTERNATIONAL 21 (3) 175 - 180 1065-6995 1997/03 [Refereed]
  
• Overexpression of cell cycle inhibitors (p16(INK4) and p21(Cip1)) and cyclin D1 using adenovirus vectors regulates proliferation of rat mesangial cells

  Y Terada; T Yamada; O Nakashima; M Tamamori; H Ito; S Sasaki; F Marumo

  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 8 (1) 51 - 60 1046-6673 1997/01 [Refereed]
  
• Calcitonin gene-related peptide (CGRP) and hypertrophy of cardiomyocytes

  H Ito; D Bell; M Tamamori; T Nozato; T Shimojo; S Adachi; S Abe; F Marumo; M Hiroe

  HEART AND VESSELS Suppl 12 15 - 17 0910-8327 1997 [Refereed]
  
• Mild hypoxia induces hypertrophy of cultured neonatal rat cardiomyocytes: A possible endogenous endothelin-1 mediated mechanism

  H Ito; S Adachi; M Tamamori; H Fujisaki; M Tanaka; MH Lin; H Akimoto; F Marumo; M Hiroe

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 28 (6) 1271 - 1277 0022-2828 1996/06 [Refereed]
  
• Heparin and heparan sulfate block angiotensin II-induced hypertrophy in cultured neonatal rat cardiomyocytes - A possible role of intrinsic heparin-like molecules in regulation of cardiomyocyte hypertrophy

  H Akimoto; H Ito; M Tanaka; S Adachi; M Hata; MH Lin; H Fujisaki; F Marumo; M Hiroe

  CIRCULATION 93 (4) 810 - 816 0009-7322 1996/02 [Refereed]
  
• Cicletanine inhibits endothelin-1-induced hypertrophy of rat cardiomyocytes.

  Lin M; Ito H; Akimoto H; Tamamori M; Fujisaki H; Adachi S; Marumo F; Hiroe M

  Pharmacometrics 51 (1) 1 - 6 0300-8533 1996 [Refereed]
  
• Endothelin-3 induces hypertrophy of cardiomyocytes by the endogenous endothelin-1-mediated mechanism

  M Tamamori; H Ito; S Adachi; H Akimoto; F Marumo; M Hiroe

  JOURNAL OF CLINICAL INVESTIGATION 97 (2) 366 - 372 0021-9738 1996/01 [Refereed]
  
• NATRIURETIC PEPTIDES INHIBIT ANGIOTENSIN-II-INDUCED PROLIFERATION OF RAT CARDIAC FIBROBLASTS BY BLOCKING ENDOTHELIN-1 GENE-EXPRESSION

  H FUJISAKI; H ITO; Y HIRATA; M TANAKA; M HATA; MH LIN; S ADACHI; H AKIMOTO; F MARUMO; M HIROE

  JOURNAL OF CLINICAL INVESTIGATION 96 (2) 1059 - 1065 0021-9738 1995/08 [Refereed]
  
• 2 ISOFORMS OF A CHLORIDE CHANNEL PREDOMINANTLY EXPRESSED IN THICK ASCENDING LIMB OF HENLE LOOP AND COLLECTING DUCTS OF RAT-KIDNEY

  S ADACHI; S UCHIDA; H ITO; M HATA; M HIROE; F MARUMO; S SASAKI

  JOURNAL OF BIOLOGICAL CHEMISTRY 269 (26) 17677 - 17683 0021-9258 1994/07 [Refereed]
  

Books etc

• 実験医学2013年12月増刊号 老化・寿命研究の最前線

  安達(玉盛)三美; 岡崎 具樹; Kleiling JA; Sedivy JM (Contributor個体でみられる細胞老化)羊土社 2013
• 心筋症を識る・診る・治す

  安達三美 (ContributorTopics 心筋細胞の再分裂誘導は可能か)文光堂 2007
• キーワードで理解する細胞周期イラストマップ

  安達 三美; 北嶋 繁孝 (Contributor再生と細胞周期)羊土社 2005
• 分子細胞治療

  安達 三美; 北嶋 繁孝 (Contributor心筋細胞の再生を目指した細胞周期機構の解明)先端医学社 2004
• 発生における細胞増殖制御

  池田正明; 安達三美 (Contributor心筋の増殖停止機構)シュプリンガー・フェアラーク東京 2004
• 「実験医学」Vol. 21 No. 5（増刊）

  池田正明; 安達 三美 (ContributorサイクリンD1の核移行制御と心筋細胞の増殖)羊土社 2003
• 心臓における生命現象の分子生物学

  玉盛三美; 伊藤 宏 (Contributor心筋細胞と細胞周期)メディカルレビュー社 2001
• 細胞外マトリックス研究法（４）

  玉盛三美; 伊藤 宏 (Contributor組織からの細胞分離と培養系の確立、心筋細胞、心線維芽細胞)コラーゲン技術研修会 1999

MISC

• Dynamic expression changes of energy metabolism-related genes in mouse liver with aging.

  小原幸弘; 諏佐崇生; 秋元美穂; 奥平准之; 久樹晴美; 飯塚眞由; 岡崎具樹; 安達三美  日本分子生物学会年会プログラム・要旨集(Web)  45th-  2022
• ヒト前立腺癌LNCaP細胞における25(OH)D3のビタミンD3活性の評価

  諏佐 崇生; 飯塚 眞由; 安達 三美; 岡崎 具樹  日本内分泌学会雑誌  94-  (1)  369  -369  2018/04
• Marked Cortisol Production By Intracrine ACTH in Gip-Treated Cultured Adrenal Cells in Which Gip Receptor Was Exogenously Introduced

  Hiroko Fujii; Mimi Tamamori-Adachi; Takao Susa; Masayoshi Iizuka; Yuji Tanaka; Tomoki Okazaki  ENDOCRINE REVIEWS  35-  (3)  2014/06
• Aberrant, but Physiological, Interactions Between the Non-Mutated Androgen Receptor and E2 in Several Sex Hormone-Responsive Cancer Cells

  Takao Susa; Reina Ikaga; Takashi Kajitani; Masayoshi Iizuka; Mimi Tamamori-Adachi; Tomoki Okazaki  ENDOCRINE REVIEWS  35-  (3)  2014/06
• Serine 21 Phosphorylation of GSK-3 alpha Mediates Myocyte Proliferation through CyclinD1/E2F Pathway under Pressure Overload

  Takahisa Matsuda; Pelyong Zhai; Chull Hong; Shumin Gao; Bin Tian; Kazumichi Goto; Mimi Tamamori-Adachi; Hiromitsu Takagi; Junichi Sadoshima  CIRCULATION  118-  (18)  S327  -S327  2008/10
• Important Role of Basic Fibroblast Growth Factor Signaling and p27kip1 in Adult Cardiomyocyte Cell Cycle Regulation

  Yasuhiro Maejima; Mimi Tamamori-Adachi; Kazuhiko Yamada; Susumu Adachi; Shigetaka Kitajima; Mitsuaki Isobe  CIRCULATION  118-  (18)  S429  -S429  2008/10
• Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

  S Kitajima; K Tamura; H Bayin; S Adachi; Guney, I; MT Adachi; Y Tanaka; JM Sedivy  FASEB JOURNAL  20-  (4)  A37  -A37  2006/03
• Nuclear localization signal-tagged cyclin D1/cdk4/skp2 gene transfer prevents left ventricular dysfunction and heart failure after myocardial infarction in rats

  H Takagi; T Hidaka; U Koshimizu; N Inomata; M Tamamori-Adachi; J Kawauchi; S Kitajima  CIRCULATION  112-  (17)  U145  -U145  2005/10
• CyclinD1 and CDK4 induce hypertrophy through phosphorylation of RNA polymerase II C-terminal domain in neonatal rat cardiomyocytes

  K Nobori; M Tamamori-Adachi; H Ito; K Hayashida; J Kawauchi; S Adachi; M Isobe; S Kitajima  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY  35-  (11)  A27  -A27  2003/11
• Nitric oxide inhibits hypoxia/reoxygenation-induced myocardial apoptosis by modulating cyclin A-associated kinase activity

  Y Maejima; S Adachi; K Morikawa; K Nobori; M Tamamori-Adachi; M Isobe; H Ito  CIRCULATION  108-  (17)  64  -64  2003/10
• Overexpression of ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes

  K Nobori; H Ito; M Tamamori-Adachi; S Adachi; Y Ono; Y Maejima; J Kawauchi; S Kitajima; M Isobe  CIRCULATION  106-  (19)  92  -93  2002/11
• Induction of cardiac muscle cell proliferatrion by transport of cyclin D1/CDK4 to nucleus

  M Tamamori-Adachi; H Ito; S Adachi; M Hiroe; J Kawauchi; M Shimizu; S Kitajima; M Ikeda  CIRCULATION  106-  (19)  204  -204  2002/11
• Transcriptional repressor ATF3 protects human umbilical vein endothelial cells from TNF-alpha-induced apoptosis through down-regulation of p53 transcription

  J Kawauchi; K Nobori; M Tamamori-Adachi; M Sunamori; S Kitajima  CIRCULATION  106-  (19)  288  -288  2002/11
• Expression of transcriptional repressor ATF3 in human atherosclerosis: Co-localization and significance in cell death of vascular endothelial cells

  T Nawa; MT Nawa; MT Adachi; Uchimura, I; K Fujisawa; A Tanaka; F Numano; S Kitajima  DIABETES  50-  A162  -A162  2001/06
• Endothelin-1 supresses nitric oxide induced caspase-3 activation and antagonizes apoptosis in cardiomyocytes

  M Hiroe; M Shichiri; S Ishiyama; T Shimojo; S Abe; S Adachi; M Tamamori; H Ito; Y Hirata; F Marumo  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY  35-  (2)  170A  -170A  2000/02
• Angiotensin II- or endothelin-1-induced cardiomyocyte hypertrophy is regulated by G1 cyclin-cdk complex via Rb phosphorylation

  T Nozato; H Ito; M Tamamori; Y Ono; T Shimojo; S Adachi; S Abe; F Marumo; M Hiroe  CIRCULATION  100-  (18)  353  -353  1999/11
• Overexpression of cdk inhibitor p16(INK4) by adenovirus vector inhibits cardiac hypertrophy induced by aortic banding in rats

  H Ito; M Watatanbe; T Nozato; M Tamamori; S Adachi; H Tanaka; M Sunamori; F Marumo; M Hiroe  CIRCULATION  100-  (18)  688  -689  1999/11
• Cyclin D1 is a key factor in hypertrophy of cardiomyocytes

  T Notato; H Ito; M Tamamori; S Adachi; S Abe; F Marumo; M Hiroe  CIRCULATION  98-  (17)  626  -626  1998/10
• Involvement of G1 cell cycle regulators in the development of cardiomyocyte hypertrophy

  M Tamamori; H Ito; M Ikeda; S Adachi; S Abe; H Akimoto; F Marumo; M Hiroe  CIRCULATION  94-  (8)  910  -910  1996/10
• ROLE OF HEPARIN-LIKE MOLECULES IN THE REGULATION OF CARDIAC-HYPERTROPHY

  H AKIMOTO; H ITO; S ADACHI; H FUJISAKI; M TANAKA; M HATA; F MARUMO; M HIROE  CIRCULATION  92-  (8)  299  -299  1995/10
• MILD HYPOXIA-INDUCED HYPERTROPHY OF CARDIAC MYOCYTES IS INHIBITED BY RECEPTOR ANTAGONIST FOR ENDOTHELIN BUT NOT FOR ANGIOTENSIN

  H ITO; M HIROE; M TANAKA; S ADACHI; H AKIMOTO; M HATA; MH LIN; F MARUMO  CIRCULATION  90-  (4)  371  -371  1994/10

Awards & Honors

• 2004/04 東京医科歯科大学 東京医科歯科大学研究奨励賞
   

  受賞者: 安達三美

Research Grants & Projects

• 副腎の老化の制御による個体老化のコントロールと健康長寿を目指す研究

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2022/04 -2025/03 

  Author : 安達 三美
• 糖質コルチコイド制御による、老化のコントロールを目指す研究

  科研費：基盤研究C

  Date (from‐to) : 2019/04 -2022/03 

  Author : 安達三美
• 加齢による糖質コルチコイド合成系の変化と老化への影響の解析

  科研費：基盤研究C

  Date (from‐to) : 2015 -2018 

  Author : 安達三美
• 老化組織におけるヘテロクロマチン構造の解析と新規バイオマーカーの探索

  科研費：基盤研究C

  Date (from‐to) : 2011 -2014 

  Author : 安達三美
• 細胞周期制御因子による心筋再生療法の開発を目指した研究

  科研費：基盤研究C

  Date (from‐to) : 2007 -2008 

  Author : 安達三美
• bZip型転写抑制因子ATF3の細胞増殖と細胞死デコードシステムの解析

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2006 -2007 

  Author : 北嶋 繁孝; 安達 三美
• c-Myc標的遺伝子ATF3の細胞増殖と発がんに関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2006 -2007 

  Author : 北嶋 繁孝; 安達 三美
• サイクリンD1の心筋特異的核内発現によるヒト心筋細胞再生法の開発

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2005 -2006 

  Author : 北嶋 繁孝; 砂盛 誠; 磯部 光章; 安達 三美
• 心筋再分裂誘導の分子機構と再生治療への応用に関する研究

  科研費：基盤研究C

  Date (from‐to) : 2005 -2006 

  Author : 安達三美
• 心筋の再生を目指した細胞周期機構の解明

  科研費：基盤研究C

  Date (from‐to) : 2003 -2004 

  Author : 安達三美
• Alternations of Transcriptional Regulation in Oral Cancers and Analysis of Tumor Suppressive functions of p300 Transcriptional Co-activator

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2001 -2003 

  Author : IKEDA Masa-aki; IKEDA Yayoi; ADACHI Mimi
• 心筋細胞の増殖抑制メカニズムの解明：心筋再生を目指して

  財団法人武田化学振興財団：報彰基金研究奨励

  Date (from‐to) : 2003 

  Author : 安達三美
• 心筋細胞における細胞周期の解明；心筋細胞の再生を目指して

  科研費：奨励研究A

  Date (from‐to) : 2001 -2002 

  Author : 安達三美
• Alternations of the Transcriptional Co-activator p300 in Oral Cancers and Its Novel Role in Tumor Suppression

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1998 -2000 

  Author : IKEDA Masa-aki; IKEDA Yayoi; ADACHI Mimi
• 心筋細胞肥大における細胞周期制御機構の関与について

  科研費：特別研究員奨励費

  Date (from‐to) : 1997 -1999 

  Author : 安達三美