Yasuhara Masato

Researcher Information

Affiliation

Faculty of Pharmaceutical Sciences Specially Appointed Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901017393692535

J-Global ID

• 200901017393692535

Research Interests

• 薬物血中濃度モニタリング   薬力学   薬物動態学   Therapeutic Drug Monitoring   Pharmacodynamics   Pharmacokinetics   地域医療   多職種連携   

Research Areas

• Life sciences / Clinical pharmacy
• Life sciences / Pharmacology
• Life sciences / Pharmaceuticals - health and biochemistry
• Life sciences / Pharmaceuticals - analytical and physicochemistry

Academic & Professional Experience

• 2017 - Today  Teikyo UniversityFaculty of Pharma-Science
• 2014 - 2017  Tokyo Medical and Dental UniversityGraduate School of Medical and Dental Sciences
• 1995 - 2014  Tokyo Medical and Dental UniversityUniversity Hospital of Medicine
• 1990 - 1994  Kyoto UniversityHospital
• 1988 - 1990  Kyoto UniversityHospital
• 1979 - 1988  Kyoto UniversityHospital

Education

•        - 1979  Kyoto University
•        - 1974  Kyoto University  Faculty of Pharmaceutical Sciences

Research Activity Information

Published Papers

• First phase 1 clinical study of olaparib in pediatric patients with refractory solid tumors.

  Masatoshi Takagi; Chitose Ogawa; Tomoko Iehara; Yuki Aoki-Nogami; Eri Ishibashi; Minoru Imai; Toshimi Kimura; Masashi Nagata; Masato Yasuhara; Mitsuko Masutani; Kenichi Yoshimura; Daisuke Tomizawa; Atsushi Ogawa; Kan Yonemori; Aoi Morishita; Satoshi Miyamoto; Junko Takita; Tetsuro Kihara; Kiyoshi Nobori; Kazuhisa Hasebe; Fuyuki Miya; Sadakatsu Ikeda; Yoko Shioda; Kimikazu Matsumoto; Junya Fujimura; Shuki Mizutani; Tomohiro Morio; Hajime Hosoi; Ryuji Koike

  Cancer 128 (15) 2949 - 2957 2022/05 [Refereed]
  
• 1996年から2016年の20年間における薬剤師の就業動向

  安藤崇仁; 井上和男; 木村一紀; 安原眞人

  厚生の指標 66 (1) 34 - 39 2022/01 [Refereed]
  
• Hematopoietic Cell Transplantation with Reduced Intensity Conditioning Using Fludarabine/Busulfan or Fludarabine/Melphalan for Primary Immunodeficiency Diseases

  Akira Nishimura; Yuki Aoki; Yasuyoshi Ishiwata; Takuya Ichimura; Junichi Ueyama; Yuta Kawahara; Takahiro Tomoda; Maiko Inoue; Kazuaki Matsumoto; Kento Inoue; Haruka Hiroki; Shintaro Ono; Motoi Yamashita; Tsubasa Okano; Mari Tanaka-Kubota; Miho Ashiarai; Satoshi Miyamoto; Reiji Miyawaki; Chika Yamagishi; Mari Tezuka; Teppei Okawa; Akihiro Hoshino; Akifumi Endo; Masato Yasuhara; Takahiro Kamiya; Noriko Mitsuiki; Toshiaki Ono; Takeshi Isoda; Masakatsu Yanagimachi; Daisuke Tomizawa; Masayuki Nagasawa; Shuki Mizutani; Michiko Kajiwara; Masatoshi Takagi; Hirokazu Kanegane; Kohsuke Imai; Tomohiro Morio

  Journal of Clinical Immunology Springer Science and Business Media LLC 41 (5) 944 - 957 0271-9142 2021/07 [Refereed]
  
• Population pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass in adult patients undergoing cardiac surgery.

  Mizuho Asada; Masashi Nagata; Tomohiro Mizuno; Tokujiro Uchida; Hiromitsu Takahashi; Koshi Makita; Hirokuni Arai; Shinichi Kijima; Hirotoshi Echizen; Masato Yasuhara

  European journal of clinical pharmacology Springer Science and Business Media LLC 77 (5) 735 - 745 0031-6970 2020/11 [Refereed]
  
• 経口抗がん薬薬物治療におけるプロトコールに基づく副作用管理の試み ～長崎大学病院と長崎県薬剤師会薬局の連携取組～

  手嶋無限; 天本耕一郎; 中村優; 池田理恵; 中村忠博; 山形浩介; 井手陽一; 水崎直文; 宮崎彰宣; 秋吉隆治; 有澤賢二; 宮崎長一郎; 安原眞人; 佐々木均; 田代治幸

  医療薬学 46 (9) 503 - 514 2020/09 [Refereed]
  
• Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol

  Masatoshi Takagi; Chitose Ogawa; Yuki Aoki-Nogami; Tomoko Iehara; Eri Ishibashi; Minoru Imai; Tetsuro Kihara; Kiyoshi Nobori; Kazuhisa Hasebe; Shuki Mizutani; Toshimi Kimura; Masashi Nagata; Masato Yasuhara; Kenichi Yoshimura; Pariko Yorozu; Hajime Hosoi; Ryuji Koike

  BMC Pediatrics Springer Science and Business Media LLC 19 (1) 2019/12 [Refereed]
  
• Effects of cardiopulmonary bypass on the disposition of cefazolin in patients undergoing cardiothoracic surgery

  M. Asada; M. Nagata; T. Mizuno; T. Uchida; N. Kurashima; H. Takahashi; K. Makita; H. Arai; H. Echizen; M. Yasuhara

  Pharmacol. Res. Perspect. (e00440) 1 - 8 2018/10 [Refereed]
  
• Clozapine-induced acute hyperglycemia is accompanied with elevated serum concentrations of adrenaline and glucagon in rats

  M. Nagata; Y. Kimura; Y. Ishiwata; H. Takahashi; M. Yasuhara

  Biol. Pharm. Bull. 41 (8) 1286 - 1290 2018/08 [Refereed]
  
• Population pharmacokinetics of intravenous busulfan in Japanese pediatric patients with primary immunodeficiency diseases

  Y. Ishiwata; M. Nagata; K. Tsuge; H. Takahashi; S. Suzuki; K. Imai; M. Takagi; H. Kanegane; T. Morio; M. Yasuhara

  J. Clin. Pharmacol. 58 (3) 327 - 331 2018 [Refereed]
  
• Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study

  Kazuo Takiguchi; Akihito Uezato; Michio Itasaka; Hidenori Atsuta; Kenji Narushima; Naoki Yamamoto; Akeo Kurumaji; Makoto Tomita; Kazunari Oshima; Kosaku Shoda; Mai Tamaru; Masahito Nakataki; Mitsutoshi Okazaki; Sayuri Ishiwata; Yasuyoshi Ishiwata; Masato Yasuhara; Kunimasa Arima; Tetsuro Ohmori; Toru Nishikawa

  BMC PSYCHIATRY BIOMED CENTRAL LTD 17 (249) 1 - 15 1471-244X 2017/07 [Refereed]
  
• HLA haploidentical hematopoietic cell transplantation using clofarabine and busulfan for refractory pediatric hematological malignancy.

  Masatoshi Takagi; Yasuyoshi Ishiwata; Yuki Aoki; Satoshi Miyamoto; Akihiro Hoshino; Kazuaki Matsumoto; Akira Nishimura; Mari Tanaka; Masakatsu Yanagimachi; Noriko Mitsuiki; Kohsuke Imai; Hirokazu Kanegane; Michiko Kajiwara; Kanako Takikawa; Tsukasa Mae; Osamu Tomita; Junya Fujimura; Masato Yasuhara; Daisuke Tomizawa; Shuki Mizutani; Tomohiro Morio

  Int. J. Hematol. 105 (5) 686 - 691 1865-3774 2017/05 [Refereed]
  
• HLA haploidentical hematopoietic cell transplantation using clofarabine and busulfan for refractory pediatric hematological malignancy

  Masatoshi Takagi; Yasuyoshi Ishiwata; Yuki Aoki; Satoshi Miyamoto; Akihiro Hoshino; Kazuaki Matsumoto; Akira Nishimura; Mari Tanaka; Masakatsu Yanagimachi; Noriko Mitsuiki; Kohsuke Imai; Hirokazu Kanegane; Michiko Kajiwara; Kanako Takikawa; Tsukasa Mae; Osamu Tomita; Junya Fujimura; Masato Yasuhara; Daisuke Tomizawa; Shuki Mizutani; Tomohiro Morio

  INTERNATIONAL JOURNAL OF HEMATOLOGY SPRINGER JAPAN KK 105 (5) 686 - 691 0925-5710 2017/05 [Refereed]
  
• Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study.

  Yasuyoshi Ishiwata; Masashi Nagata; Takafumi Arai; Misato Makiishi; Maho Yoshikawa; Hiromitsu Takahashi; Hitoshi Kohsaka; Masato Yasuhara

  Ther Drug Monit 38 (6) 717 - 721 1536-3694 2016/12 [Refereed]
  
• Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study

  Yasuyoshi Ishiwata; Masashi Nagata; Takafumi Arai; Misato Makiishi; Maho Yoshikawa; Hiromitsu Takahashi; Hitoshi Kohsaka; Masato Yasuhara

  THERAPEUTIC DRUG MONITORING LIPPINCOTT WILLIAMS & WILKINS 38 (6) 717 - 721 0163-4356 2016/12 [Refereed]
  
• Mechanism Underlying Induction of Hyperglycemia in Rats by Single Administration of Olanzapine.

  Masashi Nagata; Mayumi Nakajima; Yasuyoshi Ishiwata; Yutaka Takahashi; Hiromitsu Takahashi; Kenichi Negishi; Masato Yasuhara

  Biol. Pharm. Bull. 39 (5) 754 - 761 1347-5215 2016/05 [Refereed]
  
• Mechanism Underlying Induction of Hyperglycemia in Rats by Single Administration of Olanzapine

  Masashi Nagata; Mayumi Nakajima; Yasuyoshi Ishiwata; Yutaka Takahashi; Hiromitsu Takahashi; Kenichi Negishi; Masato Yasuhara

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 39 (5) 754 - 761 0918-6158 2016/05 [Refereed]
  
• Haploidentical Bone Marrow Transplantation With Clofarabine and Busulfan Conditioning for a Child With Multiple Recurrent Acute Lymphoblastic Leukemia

  Yuki Aoki; Reiji Miyawaki; Kohsuke Imai; Masatoshi Takagi; Michiko Kajiwara; Yasuyoshi Ishiwata; Masato Yasuhara; Tomohiro Morio; Shuki Mizutani; Daisuke Tomizawa

  JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LIPPINCOTT WILLIAMS & WILKINS 38 (1) E39 - E41 1077-4114 2016/01 [Refereed]
  
• Pharmacokinetic-Pharmacodynamic Analysis of Sunitinib-Induced Thrombocytopenia in Japanese Patients with Renal Cell Carcinoma

  Masashi Nagata; Yasuyoshi Ishiwata; Yutaka Takahashi; Hiromitsu Takahashi; Kazutaka Saito; Yasuhisa Fujii; Kazunori Kihara; Masato Yasuhara

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 38 (3) 402 - 410 0918-6158 2015/03 [Refereed]
  
• Active topical therapy by "Furuta method" for effective pressure ulcer treatment: a retrospective study.

  Katsunori Furuta; Fumihiro Mizokami; Hitoshi Sasaki; Masato Yasuhara

  Journal of pharmaceutical health care and sciences 1 (21) 1 - 9 2015 [Refereed]
  
• Effects of Moxifloxacin on Serum Glucose Concentrations in Rats

  Yasuyoshi Ishiwata; Yutaka Takahashi; Masashi Nagata; Masato Yasuhara

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 36 (4) 686 - 690 0918-6158 2013/04 [Refereed]
  
• Effect of cimetidine on pentamidine induced hyperglycemia in rats

  Toru Arino; Seiji Karakawa; Yasuyoshi Ishiwata; Masashi Nagata; Masato Yasuhara

  EUROPEAN JOURNAL OF PHARMACOLOGY ELSEVIER SCIENCE BV 693 (1-3) 72 - 79 0014-2999 2012/10 [Refereed]
  
• Pharmacodynamics of Cibenzoline-Induced Hypoglycemia in Rats

  Yutaka Takahashi; Yasuyoshi Ishiwata; Yuko Kojima; Masato Yasuhara

  DRUG METABOLISM AND PHARMACOKINETICS JAPANESE SOC STUDY XENOBIOTICS 26 (3) 242 - 247 1347-4367 2011 [Refereed]
  
• Gatifloxacin-induced histamine release and hyperglycemia in rats

  Yasuyoshi Ishiwata; Masato Yasuhara

  EUROPEAN JOURNAL OF PHARMACOLOGY ELSEVIER SCIENCE BV 645 (1-3) 192 - 197 0014-2999 2010/10
• Deficiency of Chemokine Receptor CCR1 Causes Osteopenia Due to Impaired Functions of Osteoclasts and Osteoblasts

  Akiyoshi Hoshino; Tadahiro Iimura; Satoshi Ueha; Sanshiro Hanada; Yutaka Maruoka; Mitsuori Mayahara; Keiko Suzuki; Toshio Imai; Masako Ito; Yoshinobu Manome; Masato Yasuhara; Takaaki Kirino; Akira Yamaguchi; Kouji Matsushima; Kenji Yamamoto

  JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 285 (37) 28826 - 28837 0021-9258 2010/09
• Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement.

  Yusuke Nakauchi; Hiroshi Takase; Sunao Sugita; Manabu Mochizuki; Satoko Shibata; Yasuyoshi Ishiwata; Yuka Shibuya; Masato Yasuhara; Osamu Miura; Ayako Arai

  Int. J. Hematol. 92 (1) 179 - 185 1865-3774 2010/07 [Refereed]
  
• Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement

  Yusuke Nakauchi; Hiroshi Takase; Sunao Sugita; Manabu Mochizuki; Satoko Shibata; Yasuyoshi Ishiwata; Yuka Shibuya; Masato Yasuhara; Osamu Miura; Ayako Arai

  INTERNATIONAL JOURNAL OF HEMATOLOGY SPRINGER TOKYO 92 (1) 179 - 185 0925-5710 2010/07 [Refereed]
  
• Pharmacokinetic monitoring is still required for intravenous busulfan in SCT for small children

  Masayuki Nagasawa; Noriko Mitsuiki; Toshiaki Ono; Masatoshi Takagi; Hiromi Oda; Masato Yasuhara; Shuki Mizutani

  INTERNATIONAL JOURNAL OF HEMATOLOGY SPRINGER TOKYO 91 (4) 728 - 730 0925-5710 2010/05 [Refereed]
  
• GFP expression by intracellular gene delivery of GFP-coding fragments using nanocrystal quantum dots

  HOSHINO A; MANABE N; FUJIOKA K; HANADA S; YASUHARA M; KONDO Akihiko; YAMAMOTO K

  Nanotechnology Vol. 19, No. 49, art.no.495102 (49) 495102 - 495102 2008/12 [Refereed]
  
• MPO-ANCA induces IL-17 production by activated neutrophils in vitro via classical complement pathway-dependent manner

  Akiyoshi Hoshino; Tomokazu Nagao; Noriko Nagi-Miura; Naohito Ohno; Masato Yasuhara; Kenji Yamamoto; Toshinori Nakayama; Kazuo Suzuki

  JOURNAL OF AUTOIMMUNITY ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD 31 (1) 79 - 89 0896-8411 2008/08 [Refereed]
  
• Nanocrystal quantum dot-conjugated anti-myeloperoxidase antibody as the detector of activated neutrophils

  Akiyoshi Hoshino; Tomokazu Nagao; Akira Nakasuga; Akiko Ishida-Okawara; Kazuo Suzuki; Masato Yasuhara; Kenji Yamamoto

  IEEE TRANSACTIONS ON NANOBIOSCIENCE IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC 6 (4) 341 - 345 1536-1241 2007/12 [Refereed]
  
• Separation of murine neutrophils and macrophages by thermoresponsive magnetic nanoparticles

  Akiyoshi Hoshino; Noriyuki Ohnishi; Masato Yasuhara; Kenji Yamamoto; Akihiko Kondo

  BIOTECHNOLOGY PROGRESS AMER CHEMICAL SOC 23 (6) 1513 - 1516 8756-7938 2007/11 [Refereed]
  
• Use of fluorescent quantum dot bioconjugates for cellular imaging of immune cells, cell organelle labeling, and nanomedicine : surface modification regulates biological function, including cytotoxicity

  HOSHINO Akiyoshi; MANABE Noriyoshi; FUJIOKA Kouki; SUZUKI Kazuo; YASUHARA Masato; YAMAMOTO Kenji

  J Artif Organs 3 10 (3) 149 - 157 1434-7229 2007/09
• Effects of acute renal failure and ganciclovir on the pharmacodynamics of levofloxacin-induced seizures in rats

  Yasuyoshi Ishwata; Kishin Son; Yoshie Itoga; Masato Yasuhara

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 30 (4) 745 - 750 0918-6158 2007/04 [Refereed]
  
• Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions

  Akiyoshi Hoshino; Yuki I. Kawamura; Masato Yasuhara; Noriko Toyama-Sorimachi; Kenji Yamamoto; Akihiro Matsukawa; Sergio A. Lira; Taeko Dohi

  JOURNAL OF IMMUNOLOGY AMER ASSOC IMMUNOLOGISTS 178 (8) 5296 - 5304 0022-1767 2007/04
• Trafficking of QD-conjugated MPO-ANCA in Murine Systemic Vasculitis and Glomerulonephritis model mice.

  Hoshino T; Nagao T; Ito-Ihara T; Ishida-Okawara A; Uno K; Muso E; Nagi-Miura N; Ohno N; Tokunaka K; Naoe S; Hashimoto H; Yasuhara M; Yamamoto K; Suzuki K

  Microbiol Immunol Center for Academic Pub. Japan 51 (5) 551 - 566 0385-5600 2007 [Refereed]
  
• Effect of levofloxacin on serum glucose concentration in rats

  Yasuyoshi Ishiwata; Yoshie Itoga; Masato Yasuhara

  EUROPEAN JOURNAL OF PHARMACOLOGY ELSEVIER SCIENCE BV 551 (1-3) 168 - 174 0014-2999 2006/12
• Effects of gatifloxacin on serum glucose concentration in normal and diabetic rats

  Y Ishiwata; Y Sanada; M Yasuhara

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 29 (3) 527 - 531 0918-6158 2006/03 [Refereed]
  
• Immune cells tracing using quantum dots

  Akiyoshi Hoshino; Kouki Fujioka; Yuki I. Kawamura; Noriko Toyama-Sorimachi; Masato Yasuhara; Taeko Dohi; Kenji Yamamoto

  Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6096 1605-7422 2006 [Refereed]
  
• Simultaneous Multicolor Detection System of the Single-Molecular Microbial Antigen with Total Internal Reflection Fluorescence Microscopy

  HOSHINO Akiyoshi; FUJIOKA Kouki; MANABE Noriyoshi; YAMAYA Shun-ichi; GOTO Yoji; YASUHARA Masato; YAMAMOTO Kenji

  Microbiology and Immunology Center for Academic Pub. Japan 49 (5) 461 - 470 0385-5600 2005/05
• Effect of isoniazid on the pharmacodynamics of cefazolin-induced seizures in rats

  Y. Ishiwata; M. Nagata; M. Yasuhara

  Drug Metab. Pharmacokin. 20 (2) 117 - 120 2005/04 [Refereed]
  
• Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification

  A Hoshino; K Fujioka; T Oku; M Suga; YF Sasaki; T Ohta; M Yasuhara; K Suzuki; K Yamamoto

  NANO LETTERS AMER CHEMICAL SOC 4 (11) 2163 - 2169 1530-6984 2004/11 [Refereed]
  
• Quantum dots targeted to the assigned organelle in living cells.

  Hoshino A; Fujioka K; Oku T; Nakamura S; Suga M; Yamaguchi Y; Suzuki K; Yasuhara M; Yamamoto K

  Microbiology and immunology 12 48 (12) 985 - 994 0385-5600 2004 [Refereed]
  
• Effect of experimental renal failure and hypotonic hyponatremia on the pharmacodynamics of cefazolin-induced seizures in rats

  M Nagata; T Fujichika; M Yasuhara

  PHARMACEUTICAL RESEARCH KLUWER ACADEMIC/PLENUM PUBL 20 (6) 937 - 942 0724-8741 2003/06
• The increased intestinal absorption rate is responsible for the reduced hepatic first-pass extraction of propranolol in rats with cisplatin-induced renal dysfunction

  H Okabe; A Mizukami; M Taguchi; T Aiba; M Yasuhara; Y Hashimoto

  JOURNAL OF PHARMACY AND PHARMACOLOGY ROYAL PHARMACEUTICAL SOC GREAT BRITAIN 55 (4) 479 - 486 0022-3573 2003/04 [Refereed]
  
• Effect of experimental renal failure on the pharmacokinetics of losartan in rats

  T Yoshitani; H Yagi; N Inotsume; M Yasuhara

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 25 (8) 1077 - 1083 0918-6158 2002/08
• Effect of experimental renal failure on the pharmacodynamics of cefoselis-induced seizures in rats

  M Nagata; M Yasuhara

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 24 (9) 1049 - 1052 0918-6158 2001/09 [Refereed]
  
• Quantitative estimation of renal clearance of N-acetylprocainamide in Rats with various experimental acute renal failure

  YL He; N Kitada; M Yasuhara; R Hori

  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES ELSEVIER SCIENCE BV 13 (3) 303 - 308 0928-0987 2001/06 [Refereed]
  
• Effect of experimental renal dysfunction on bioavailability of ajmaline in rats

  Y Hashimoto; T Aiba; M Yasuhara; R Hori

  JOURNAL OF PHARMACY AND PHARMACOLOGY WILEY-BLACKWELL 53 (6) 805 - 813 0022-3573 2001/06 [Refereed]
  
• Pharmacokinetics and pharmacological effect of recombinant human granulocyte colony-stimulating factor conjugated to poly(styrene-co-maleic acid) in rats

  J Kunimasa; Y Itoga; M Yasuhara; R Hori; K Inui

  JOURNAL OF PHARMACY AND PHARMACOLOGY ROYAL PHARMACEUTICAL SOC GREAT BRITAIN 51 (7) 777 - 782 0022-3573 1999/07 [Refereed]
  
• Effect of acute renal failure on the disposition of cefoperazone

  H Katayama; M Yasuhara; R Hori

  JOURNAL OF PHARMACY AND PHARMACOLOGY ROYAL PHARMACEUTICAL SOC GREAT BRITAIN 51 (3) 361 - 366 0022-3573 1999/03 [Refereed]
  
• Population pharmacokinetics of vancomycin in Japanese pediatric patients

  M Yasuhara; T Iga; H Zenda; K Okumura; T Oguma; Y Yano; R Hori

  THERAPEUTIC DRUG MONITORING LIPPINCOTT WILLIAMS & WILKINS 20 (6) 612 - 618 0163-4356 1998/12 [Refereed]
  
• Population pharmacokinetics of vancomycin in Japanese adult patients

  M Yasuhara; T Iga; H Zenda; K Okumura; T Oguma; Y Yano; R Hori

  THERAPEUTIC DRUG MONITORING LIPPINCOTT WILLIAMS & WILKINS 20 (2) 139 - 148 0163-4356 1998/04
• Vancomycinの有効性、安全性に関与する要因の統計解析

  尾熊隆嘉; 矢野義孝; 財前政美; 牡丹義弘; 伊賀立二; 全田 浩; 奥村勝彦; 安原眞人; 堀 了平

  日本化学療法学会雑誌 (公社)日本化学療法学会 45 (12) 987 - 994 1340-7007 1997/12 [Refereed]
  
• バンコマイシンTDMにおける母集団薬物速度論的解析と評価

  矢野義孝; 尾熊隆嘉; 安原眞人; 伊賀立二; 全田 浩; 奥村勝彦; 堀 了平

  TDM研究 (一社)日本TDM学会 14 (3) 231 - 236 0911-1026 1997 [Refereed]
  
• In-vivo Clearance Study of Vancomycin in Rats

  Tsutomu Nakamura; Mikihisa Takano; Masato Yasuhara; Ken-Ichi Inui

  Journal of Pharmacy and Pharmacology Pharmaceutical Press 48 (11) 1197 - 1200 0022-3573 1996/11 [Refereed]
  
• Modulation of organic cation transport and lipid fluidity by benzyl alcohol in rat renal brush-border membranes.

  Tomohiro Nabekura; Mikihisa Takano; Michio Kimura; Masato Yasuhara; Ken-ichi Inui

  Pharmaceutical Research 13 (7) 1069 - 1072 1996/07 [Refereed]
  
• Effect of Cyclosporin Analogues and FK506 on Transcellular Transport of Daunorubicin and Vinblastine via P-glycoprotein

  Kumiko Tanaka; Midori Hirai; Yusuke Tanigawara; Masato Yasuhara; Ryohei Hori; Kazumitsu Ueda; Ken-ichi Inui

  Pharmaceutical Research 13 (7) 1073 - 1077 1996/07 [Refereed]
  
• Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model

  Atsuko Odani; Yukiya Hashimoto; Kazunobu Takayanagi; Yuko Otsuki; Toshiko Koue; Mikihisa Takano; Masato Yasuhara; Haruo Hattori; Kenshi Furusho; Ken-Ichi Inui

  Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 19 (3) 444 - 448 0918-6158 1996/03 [Refereed]
  
• Transport of levofloxacin in a kidney epithelial cell line, LLC-PK1: Interaction with organic cation transporters in apical and basolateral membranes.

  Takeshi Ohtomo; Hideyuki Saito; Nobuo Inotsume; Masato Yasuhara; Ken-ichi Inui

  Journal of Pharmacology and Experimental Therapeutics 276 (3) 1143 - 1148 1996 [Refereed]
  
• Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells.

  Mikihisa Takano; Junya Nagai; Masato Yasuhara; Ken-ichi Inui

  American Journal of Physiology (Renal Fluid Electrolyte Physiology) 271 F469 - F475 1996 [Refereed]
  
• Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein

  M Hirai; K Tanaka; T Shimizu; Y Tanigawara; M Yasuhara; R Hori; Y Kakehi; O Yoshida; K Ueda; T Komano; K Inui

  Journal of Pharmacology and Experimental Therapeutics 275 (1) 73 - 78 1995/10 [Refereed]
  
• Specificity of p-aminohippurate transport system in the OK kidney epithelial cell line

  J Nagai; M Takano; K Hirozane; M Yasuhara; K Inui

  Journal of Pharmacology and Experimental Therapeutics 274 (3) 1161 - 1166 1995/09 [Refereed]
  
• Simulation for population analysis of Michaelis-Menten elimination kinetics

  Yukiya Hashimoto; Toshiko Koue; Yuko Otsuki; Masato Yasuhara; Ryohei Hori; Ken-ichi Inui

  Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers 23 (2) 205 - 216 0090-466X 1995/04 [Refereed]
  
• Pharmacokinetics and pharmacodynamics of FK 506 in pediatric patients receiving living-related donor liver transplantations

  M. Yasuhara; T. Hashida; M. Toraguchi; Y. Hashimoto; M. Kimura; K. Inui; R. Hori; Y. Inomata; K. Tanaka; Y. Yamaoka

  Transplantation Proceedings 27 (1) 1108 - 1110 1995/02 [Refereed]
  
• Transport of oral cephalosporins by the H+/dipeptide cotransporter and distribution of the transport activity in isolated rabbit intestinal epithelial cells

  Y Tomita; M Takano; M Yasuhara; R Hori; K Inui

  Journal of Pharmacology and Experimental Therapeutics 272 (1) 63 - 69 1995/01 [Refereed]
  
• Natriuretic Peptide-Potentiating Actions of Neutral Endopeptidase Inhibition in Rats with Experimental Heart Failure

  Masato Yasuhara; Masayuki Yamaguchi; Hiromasa Shimizu; Yukiya Hashimoto; Norio Hama; Hiroshi Itoh; Kazuwa Nakao; Ryohei Hori

  Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists 11 (12) 1726 - 1730 1573-904X 1994/12 [Refereed]
  
• Functional evidence for an apical ANP receptor in LLC-PK1 kidney epithelial cells

  Yukiya Hashimoto; Junko Ozaki; Masato Yasuhara; Ryohei Hori; Shin-ichi Suga; Hiroshi Itoh; Kazuwa Nakao; Ken-inchi Inui

  European Journal of Pharmacology: Molecular Pharmacology 268 (3) 443 - 445 0922-4106 1994/08 [Refereed]
  
• Differential sensitivity of organic anion transporters in rat renal brush-border membrane to diethyl pyrocarbonate

  Mikihisa Takano; Junya Nagai; Tomonobu Okano; Kiyoshi Hirozane; Masato Yasuhara; Ryohei Hori

  BBA - Biomembranes 1192 (2) 190 - 196 0005-2736 1994/06 [Refereed]
  
• Cellular Toxicity of Aminoglycoside Antibiotics in G418-Sensitive and -Resistant LLC-PK1 Cells

  Mikihisa Takano; Masahiro Okuda; Masato Yasuhara; Ryohei Hori

  Pharmaceutical Research 11 (5) 609 - 615 1994/05 [Refereed]
  
• Simulation for the Analysis of Distorted Pharmacodynamic Data

  Yukiya Hashimoto; Junko Ozaki; Toshiko Koue; Atsuko Odani; Masato Yasuhara; Ryohei Hori

  Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists 11 (4) 545 - 548 1573-904X 1994/04 [Refereed]
  
• Bestatin transport in rabbit intestinal brush-border membrane vesicles

  Mikihisa Takano; Yoshiko Tomita; Toshiya Katsura; Masato Yasuhara; Ken-ichi Inui; Ryohei Hori

  Biochemical Pharmacology 47 (6) 1089 - 1090 0006-2952 1994/03 [Refereed]
  
• Predictive performance of the Bayesian analysis: Effects of blood sampling time, population parameters, and pharmacostatistical model

  Yusuke Tanigawara; Ikuko Yano; Kazuo Kawakatsu; Koichi Nishimura; Masato Yasuhara; Ryohei Hori

  Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers 22 (1) 59 - 71 0090-466X 1994/02 [Refereed]
  
• Transport of gentamicin and fluid-phase endocytosis markers in the LLC-PK1 kidney epithelial cell line

  M Takano; Y Ohishi; M Okuda; M Yasuhara; R Hori

  Journal of Pharmacology and Experimental Therapeutics 268 (2) 669 - 674 1994/02 [Refereed]
  
• POPULATION ANALYSIS OF THE DOSE-DEPENDENT PHARMACOKINETICS OF ZONISAMIDE IN EPILEPTIC PATIENTS

  Y HASHIMOTO; A ODANI; Y TANIGAWARA; M YASUHARA; T OKUNO; R HORI

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 17 (2) 323 - 326 0918-6158 1994/02 [Refereed]
  
• Clearance Mechanisms of Atrial and Brain Natriuretic Peptides in Rats

  Yukiya Hashimoto; Kazuwa Nakao; Norio Hama; Hiroo Imura; Sachiyo Mori; Masayuki Yamaguchi; Masato Yasuhara; Ryohei Hori

  Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists 11 (1) 60 - 64 1573-904X 1994/01 [Refereed]
  
• Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney

  N Okamura; M Hirai; Y Tanigawara; K Tanaka; M Yasuhara; K Ueda; T Komano; R Hori

  Journal of Pharmacology and Experimental Therapeutics 266 (3) 1614 - 1619 1993/09 [Refereed]
  
• TRANSPORT MECHANISM OF CHOLINE IN RAT RENAL BRUSH-BORDER MEMBRANE

  M TAKANO; T KATSURA; Y TOMITA; M YASUHARA; R HORI

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 16 (9) 889 - 894 0918-6158 1993/09 [Refereed]
  
• Nonlinear mixed effect modeling of the pharmacodynamics of natriuretic peptides in rats

  Yukiya Hashimoto; Sachiyo Mori; Norio Hama; Kazuwa Nakao; Hiroo Imura; Masayuki Yamaguchi; Masato Yasuhara; Ryohei Hori

  Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers 21 (3) 281 - 297 0090-466X 1993/06 [Refereed]
  
• Transport of bestatin in rat renal brush-border membrane vesicles

  Hori Ryohei; Tomita Yoshiko; Katsura Toshiya; Yasuhara Masato; Inui Ken-Ichi; Takano Mikihisa

  Biochemical Pharmacology 45 (9) 1763 - 1768 0006-2952 1993/05 [Refereed]
  
• Population pharmacokinetics of theophylline. II. Intravenous infusion to patients with stable chronic airway obstruction

  Ikuko Yano; Yusuke Tanigawara; Masato Yasuhara; Katsuhiko Okumura; Ryohei Hori; Kazuo Kawakatsu; Koichi Nishimura

  Biological and Pharmaceutical Bulletin 16 (5) 501 - 505 1347-5215 1993/05 [Refereed]
  
• Decreased Cellular Toxicity of Neomycin in a Clonal Cell Line Isolated from LLC-PK1

  Ryohei Hori; Masahiro Okuda; Yoshiko Ohishi; Masato Yasuhara; Ken-ichi Inui; Mikihisa Takano

  Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists 10 (4) 573 - 576 1573-904X 1993/04 [Refereed]
  
• Characteristics of organic cation transporter in rat renal basolateral membrane

  Toshiya Katsura; Mikihisa Takano; Yoshiko Tomita; Masato Yasuhara; Ken-ichi Inui; Ryohei Hori

  BBA - Biomembranes 1146 (2) 197 - 202 0005-2736 1993/03 [Refereed]
  
• Population pharmacokinetics of theophylline. I: Intravenous infusion to children in the acute episode of asthma

  Ikuko Yano; Yusuke Tanigawara; Masato Yasuhara; Ryohei Hori; Haruki Mikawa

  Biological and Pharmaceutical Bulletin 16 (1) 59 - 62 1347-5215 1993/01 [Refereed]
  
• Inhibition of Apical Membrane Enzyme Activities and Protein Synthesis by Gentamicin in a Kidney Epithelial Cell Line LLC-PK

  Masahiro Okuda; Mikihisa Takano; Masato Yasuhara; Ryohei Hori

  Chemical and Pharmaceutical Bulletin 40 (12) 3307 - 3310 1347-5223 1992/12 [Refereed]
  
• Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1)

  Y Tanigawara; N Okamura; M Hirai; M Yasuhara; K Ueda; N Kioka; T Komano; R Hori

  Journal of Pharmacology and Experimental Therapeutics 263 (2) 840 - 845 1992/11 [Refereed]
  
• Effect of leukotriene C4 on theophylline disposition in guinea pigs

  Y. Tanigawara; I. Yano; M. Yasuhara; R. Hori

  American Review of Respiratory Disease 146 (3) 616 - 620 0003-0805 1992/09 [Refereed]
  
• Transport of procainamide in a kidney epithelial cell line LLC-PK1

  Mikihisa Takano; Miyako Kato; Akira Takayama; Masato Yasuhara; Ken-ichi Inui; Ryohei Hori

  BBA - Biomembranes 1108 (2) 133 - 139 0005-2736 1992/07
• Mechanisms of Pharmacokinetic Interaction between Propranolol and Quinidine in Rats.

  YAMADA Kazushi; YASUHARA Masato; YATSUZUKA Atsushi; OKUMURA Katsuhiko; SAKURAI Tsunetaro; KAWAI Chuichi; HORI Ryohei

  Chemical and Pharmaceutical Bulletin The Pharmaceutical Society of Japan 40 (7) 1876 - 1879 0009-2363 1992/07 [Refereed]
  
• Surface binding and intracellular uptake of gentamicin in the cultured kidney epithelial cell line (LLC-PK1)

  R Hori; M Okuda; Y Ohishi; M Yasuhara; M Takano

  Journal of Pharmacology and Experimental Therapeutics 261 (3) 1200 - 1205 1992/06 [Refereed]
  
• Pharmacokinetics of brain natriuretic peptide in rats

  Yukiva Hashimoto; Kazuwa Nakao; Norio Hama; Masashi Mukoyama; Hiroo Imura; Masato Yasuhara; Ryohei Hori

  Chemical and Pharmaceutical Bulletin 40 (6) 1650 - 1652 1347-5223 1992/06 [Refereed]
  
• Expression of renal organic cation transporter in Xenopus laevis oocytes

  R. Hori; M. Hirai; T. Katsura; M. Takano; M. Yasuhara; S. Kaneko; M. Satoh

  Biochemical Journal 283 (2) 409 - 411 0264-6021 1992/04 [Refereed]
  
• A comparative study on immunosuppressive effects of cyclosporin A and FK506 on peripheral blood lymphocytes in dogs

  K Takaori; Y Nio; K Inoue; T Tun; M Fukumoto; T Hashida; M Yasuhara; R Hori; T Tobe

  Biotherapy 4 129 - 137 1992 [Refereed]
  
• Effects of FK 506 on in vivo immunity in comparison to cyclosporine

  K Takaori; Y Nio; K Inoue; T Aung; T Tun; T Hashida; M Yasuhara; R Hori; T Tobe

  Transplantation Proceedings 23 (6) 2948 - 2949 1991/12 [Refereed]
  
• Effect of folinic acid on tissue residence and excretion of methotrexate in rats

  Y L He; Y Tanigawara; M Yasuhara; R Hori

  Drug Metabolism and Disposition 19 (4) 729 - 734 1991/07 [Refereed]
  
• Alteration of Propranolol Pharmacokinetics and Pharmacodynamics by Quinidine in Man

  Masato Yasuhara; Atsushi Yatsuzuka; Kazushi Yamada; Katsuhiko Okumura; Ryohei Hori; Tsunetaro Sakurai; Chuichi Kawai

  Journal of Pharmacobio-Dynamics 13 (11) 681 - 687 0386-846X 1990/11
• Effect of protein binding on the disposition of cephalexin and cefazolin in a simultaneous perfusion system of rat liver and kidney.

  Katsuhiko OKUMURA; Hirokazu KATAYAMA; Masato YASUHARA; Ryohei HORI

  Chemical and Pharmaceutical Bulletin The Pharmaceutical Society of Japan 37 (11) 3150 - 3152 0009-2363 1989/11 [Refereed]
  
• Pharmacokinetics and dromotropic activity of ajmaline in rats with hyperthyroidism

  Yukiya Hashimoto; Masato Yasuhara; Akira Kamiya; Katsuhiko Okumura; Ryohei Hori

  British Journal of Pharmacology 96 (1) 163 - 169 1476-5381 1989/01
• Caffeine as a potential risk factor for theophylline neurotoxicity

  M Yasuhara; G Levy

  Journal of Pharmaceutical Sciences 77 (9) 745 - 747 1988/09 [Refereed]
  
• Kinetics of drug action in disease states XXVIII: Effect of acute hypovolemia on theophylline-induced neurotoxicity in rats

  Masato Yasuhara; Gerhard Levy

  Journal of Pharmaceutical Sciences 77 (8) 729 - 730 1988/08 [Refereed]
  
• Kinetics of drug action in disease states. XXVII. Effect of experimental renal failure on the pharmacodynamics of zoxazolamine and chlorzoxazone

  M Yasuhara; G Levy

  Journal of Pharmacology and Experimental Therapeutics 246 (1) 165 - 169 1988/07
• Pharmacodynamics of Zoxazolamine and Chlorzoxazone in Rats

  Masato Yasuhara; Gerhard Levy

  Pharmaceutical Research 5 (7) 401 - 407 1988/07 [Refereed]
  
• Effect of Age on Neurotoxicity of Theophylline

  Masato Yasuhara; Gerhard Levy

  Journal of Pharmaceutical Sciences 77 (7) 645 - 646 1988/07 [Refereed]
  
• Kinetics of drug action in disease states. XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats

  M Yasuhara; G Levy

  Journal of Pharmaceutical Sciences 77 (7) 569 - 570 1988/07 [Refereed]
  
• Rapid Development of Functional Tolerance to Caffeine-Induced Seizures in Rats

  Masato Yasuhara; Gerhard Levy

  Proc Soc Exp Biol Med 188 (2) 185 - 190 1988/06 [Refereed]
  
• Regional myocardial ajmaline concentration and antiarrhythmic activity for ischaemia‐ and reperfusion‐induced arrhythmias in rats

  Katsuhiko Okumura; Yukiya Hashimoto; Masato Yasuhara; Ryohei Hori

  British Journal of Pharmacology 93 (4) 827 - 832 1476-5381 1988/04 [Refereed]
  
• Kinetics of drug action in disease states. XIX. Effect of experimental liver disease on the neurotoxicity of theophylline in rats

  I M Ramzan; M Yasuhara; G Levy

  Journal of Pharmacology and Experimental Therapeutics 241 (1) 236 - 238 1987/04 [Refereed]
  
• Kinetics of ajmaline disposition and pharrnacologic response in beagle dogs

  Masato Yasuhara; Yukiya Hashimoto; Katsuhiko Okumura; Ryohei Hori; Tsunetaro Sakurai; Chuichi Kawai

  Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers 15 (1) 39 - 55 0090-466X 1987/02 [Refereed]
  
• Pharmacokinetics and antiarrhythmic activity of ajmaline in rats subjected to coronary artery occlusion

  Yukiya Hashimoto; Ryohei Hori; Katsuhiko Okumura; Masato Yasuhara

  British Journal of Pharmacology 88 (1) 71 - 77 1476-5381 1986/05 [Refereed]
  
• Mechanisms of pharmacokinetic interaction between ajmaline and quinidine in rats.

  YAMADA KAZUSHI; YATSUZUKA ATSUSHI; YASUHARA MASATO; OKUMURA KATSUHIKO; HORI RYOHEI; SAKURAI TSUNETARO; KAWAI CHUICHI

  Journal of Pharmacobio-Dynamics The Pharmaceutical Society of Japan 9 (4) 347 - 351 0386-846X 1986/04 [Refereed]
  
• An analysis program MULTI(ELS) based on extended nonlinear least squares method for microcomputers

  K. Yamaoka; H. Tanaka; K. Okumura; M. Yasuhara; R. Hori

  Journal of Pharmacobio-Dynamics 9 (2) 161 - 173 1986/02 [Refereed]
  
• Effect of altered plasma protein binding on pharmacokinetics and pharmacodynamics of propranolol in rats after surgery: role of alpha-1-acid glycoprotein

  M Yasuhara; J Fujiwara; S Kitade; H Katayama; K Okumura; R Hori

  Journal of Pharmacology and Experimental Therapeutics 235 (2) 513 - 520 1985/11 [Refereed]
  
• Identification of the major binding protein of salmon calcitonin in the rat

  Yoshihiro Saito; Masato Yasuhara; Katsuhiko Okumura; Ryohei Hori

  Biochemical Pharmacology 34 (19) 3543 - 3546 0006-2952 1985/10 [Refereed]
  
• Reduced hepatic uptake of propranolol in rats with acute renal failure

  Ryohei Hori; Katsuhiko Okumura; Masato Yasuhara; Hirokazu Katayama

  Biochemical Pharmacology 34 (15) 2679 - 2683 0006-2952 1985/08 [Refereed]
  
• Influence of acute renal failure on pharmacokinetics of phenolsulfonphthalein in rats: A comparative study in vivo and in the simultaneous perfusion system of liver and kidney.

  YASUHARA MASATO; KATAYAMA HIROKAZU; FUJIWARA JUNKO; OKUMURA KATSUHIKO; HORI RYOHEI

  Journal of Pharmacobio-Dynamics The Pharmaceutical Society of Japan 8 (5) 377 - 384 0386-846X 1985/05 [Refereed]
  
• A nonlinear multiple regression program, MULT12 (BAYES), based on bayesian algorithm for microcomputers.

  YAMAOKA KIYOSHI; NAKAGAWA TERUMICHI; TANAKA HISASHI; YASUHARA MASATO; OKUMURA KATSUHIKO; HORI RYOHEI

  Journal of Pharmacobio-Dynamics The Pharmaceutical Society of Japan 8 (4) 246 - 256 0386-846X 1985/04 [Refereed]
  
• High molecular weight derivative of salmon calcitonin with prolonged hypocalcemic activity

  Yoshihiro Saito; Masato Yasuhara; Katsuhiko Okumura; Ryohei Hori

  Journal of Pharmaceutical Sciences 74 (3) 345 - 347 1520-6017 1985/03 [Refereed]
  
• Characterization of high molecular weight forms of peptide drugs in vivo

  Katsuhiko Okumura; Yoshihiro Saito; Masato Yasuhara; Ryohei Hori

  Journal of Pharmacobio-Dynamics 7 (12) 917 - 922 0386-846X 1984/12 [Refereed]
  
• In vivo conversion of peptide drugs into high molecular weight forms

  Ryohei Hori; Yoshihiro Saito; Masato Yasuhara; Katsuhiko Okumura

  Journal of Pharmacobio-Dynamics 7 (12) 910 - 916 0386-846X 1984/12 [Refereed]
  
• Drug elimination function of rat small intestine: Metabolism and intraluminal excretion

  Masato Yasuhara; Yuji Kurosaki; Toshikiro Kimura; Hitoshi Sezaki

  Biochemical Pharmacology 33 (20) 3131 - 3136 0006-2952 1984/10 [Refereed]
  
• Increased availability of propranolol in rats with uranyl nitrate-induced acute renal failure

  Hirokazu Katayama; Junko Fujiwara; Masato Yasuhara; katsuhiko Okumura; Ryohei Hori

  Journal of Pharmacobio-Dynamics 7 (8) 536 - 544 0386-846X 1984/08 [Refereed]
  
• Quinidine‐induced rise in ajmaline plasma concentration

  Ryohei Hori; Katsuhiko Okumura; Ken‐Ichi Inui; Masato Yasuhara; Kazushi Yamada; Tsunetaro Sakurai; Chuichi Kawai

  Journal of Pharmacy and Pharmacology 36 (3) 202 - 204 2042-7158 1984/03
• Transport Characteristics of p-Acetamidobenzoic Acid in Brush Border Membrane of Rat Small Intestine

  MASATO YASUHARA; TOSHIKIRO KIMURA; HITOSHI SEZAKI

  Journal of Pharmacobio-Dynamics 6 (11) 888 - 891 0386-846X 1983/11 [Refereed]
  
• The use of liposomes as a model for drug absorption: β-lactam antibiotics

  Toshikiro Kimura; Michiyo Yoshikawa; Masato Yasuhara; Hitoshi Sezaki

  Journal of Pharmacy and Pharmacology 32 (1) 394 - 398 1980/09 [Refereed]
  
• EFFECT OF SURFACTANTS ON THE ABSORPTION OF p-AMINOBENZOIC ACID FROM THE RAT INTESTINE

  MASATO YASUHARA; TOSHIO YOSHINO; TOSHIKIRO KIMURA; SHOZO MURANISHI; HITOSHI SEZAKI

  Journal of Pharmacobio-Dynamics 2 (4) 251 - 256 1979/08 [Refereed]
  
• COMPARATIVE STUDIES ON THE ABSORPTION MECHANISM OF p-AMINOBENZOIC ACID AND p-ACETAMIDOBENZOIC ACID FROM THE RAT INTESTINE

  MASATO YASUHARA; HIROYUKI KOBAYASHI; YUJI KUROSAKI; TOSHIKIRO KIMURA; SHOZO MURANISHI; HITOSHI SEZAKI

  Journal of Pharmacobio-Dynamics 2 (3) 177 - 186 1979/06 [Refereed]
  
• ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT SMALL INTESTINE IN SITU

  MASATO YASUHARA; HIROYUKI KOBAYASHI; TOSHIKIRO KIMURA; SHOZO MURANISHI; HITOSHI SEZAKI

  Journal of Pharmacobio-Dynamics 1 (2) 122 - 131 1978/04 [Refereed]
  
• ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT INTESTINE IN VITRO

  MASATO YASUHARA; HIROYUKI KOBAYASHI; SHOZO MURANISHI; HITOSHI SEZAKI; TOSHIKIRO KIMURA

  Journal of Pharmacobio-Dynamics 1 (2) 114 - 121 1978/04 [Refereed]
  
• Catalytic effect of cationic surfactants on degradation of cephalexin in aqueous solution

  Masato Yasuhara; Fumiko Sato; Toshikiro Kimura; Shozo Muranishi; Hitoshi Sezaki

  Journal of Pharmacy and Pharmacology 29 (1) 638 - 640 1977/09 [Refereed]
  
• Intestinal Absorption Aspect of Non-lipophilic Low Molecular Weight Drugs : A Case of Cephalexin and Cefazolin

  M. Yasuhara; Y. Miyoshi; A. Yuasa; T. Kimura; S. Muranishi; H. Sezaki

  Chemical and Pharmaceutical Bulletin 25 (4) 675 - 679 1977/04 [Refereed]
  
• Role of Membrane Components, Glycocalyx and Lipid in Absorption of Water-soluble Dyes from the Rat Small Intestine

  J. Nakamura; Y. Yoshizaki; M. Yasuhara; T. Kimura; S. Muranishi; H. Sezaki

  Chemical and Pharmaceutical Bulletin 24 (4) 691 - 697 1976/04 [Refereed]
  
• Mechanisms of the Absorption of Water-soluble Dyes from the Rat Small Intestine

  JUNZO NAKAMURA; YAEKO YOSHIZAKI; MASATO YASUHARA; TOSHIKIRO KIMURA; SHOZO MURANISHI; HITOSHI SEZAKI

  Chemical and Pharmaceutical Bulletin 24 (4) 683 - 690 1976/04 [Refereed]
  

MISC

• Issuance of Recommendation Entitled “Profession and Lifelong Learning of Pharmacists Responsible for Sustainable Medical Care” by Science Council of Japan and Subsequent Response

  Masato Yasuhara  YAKUGAKU ZASSHI  142-  (9)  929  -935  2022/09  [Refereed][Invited]
  
• Present and Future of the Japanese Pharmacopoeia in the Clinical Setting and Pharmacy Education

  Masato Yasuhara  YAKUGAKU ZASSHI  140-  (6)  767  -771  2020/06
• Cultivation of sensitivity to reverse translational research through pharmacy education

  Masato Yasuhara  Journal of Asian Association of Schools of Pharmacy  7-  21  -23  2018/12  [Refereed]
  
• プロトコールに基づく医療機関と薬局間の連携による経口抗がん薬治療管理

  安原眞人; 有澤賢二; 遠藤一司; 大塚昌孝; 奥田真弘; 片倉法明; 佐々木均; 下村直樹; 高橋弘充; 立松三千子; 長久保久仁子; 永田将司; 縄田修一; 松井礼子; 村田勇人; 山本弘史  日本薬学会年会要旨集(CD-ROM)  138th-  (4)  ROMBUNNO.27F‐pm23  -58  2018/03
• P0367-21-PM 小児におけるブスルファン血中濃度モニタリング : 低用量試験投与の有用性について(TDM・投与設計,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

  石渡 泰芳; 永田 将司; 瀧川 加奈子; 高橋 弘充; 今井 耕輔; 高木 正稔; 金兼 弘和; 森尾 友宏; 安原 眞人  日本医療薬学会年会講演要旨集  25-  327  -327  2015/10
• P0074-22-AM 病棟常駐薬剤師による定時処方の事前確認の試行と評価(病棟薬剤業務1,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

  藤田 早織; 早船 彩花; 竹節 七美; 永田 将司; 高橋 弘充; 安原 眞人  日本医療薬学会年会講演要旨集  25-  278  -278  2015/10
• P1106-23-AM Antimicrobial Stewardshipに向けたICT業務の検討(感染制御(治療薬)2,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

  相曽 啓史; 森 美奈子; 佐瀬 裕子; 永田 将司; 貫井 陽子; 高橋 弘充; 安原 眞人  日本医療薬学会年会講演要旨集  25-  450  -450  2015/10
• P0222-22-AM 抗菌薬適正使用に向けたDPCデータを利用した抗菌薬使用状況調査(使用状況調査・意識調査1,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

  杉井 麻耶; 大迫 朗子; 鶴見 彩; 萩原 奈央; 八田部 良子; 相曽 啓史; 森 美奈子; 永田 将司; 高橋 弘充; 安原 眞人  日本医療薬学会年会講演要旨集  25-  302  -302  2015/10
• 28-P4PM-073 小児急性白血病の移植前処置におけるブスルファン1日1回投与後の血中濃度モニタリング(TDM・投与設計2,一般演題(ポスター),新時代を拓く医療薬学フロンティア)

  石渡 泰芳; 永田 将司; 高橋 弘充; 富澤 大輔; 青木 由貴; 宮脇 零士; 森尾 友宏; 安原 眞人  日本医療薬学会年会講演要旨集  24-  439  -439  2014/08
• P1-045 整形外科病棟における薬剤師常駐の試行と評価(薬剤管理指導・病棟薬剤業務,ポスター,一般演題,岐路に立つ医療〜千年紀の目覚め〜よみがえれ!ニッポン!薬の改革は我らが手で!)

  成田 早織; 日高 由加里; 有野 徹; 青柳 繁; 吉田 浩美; 永田 将司; 根津 雅和; 安原 眞人; 大川 淳  日本医療薬学会年会講演要旨集  22-  274  -274  2012/10
• P-0841 ラットにおけるブスルファンによる痙攣のファーマコダイナミックス(一般演題 ポスター発表,薬物病態(基礎),Enjoy Pharmacists' Lifestyles)

  磯崎 亮輔; 石渡 泰芳; 永田 将司; 安原 眞人  日本医療薬学会年会講演要旨集  21-  322  -322  2011/09
• P2-232 ラットにおけるクロルフェニラミンによる痙攣のファーマコダイナミックス(一般演題 ポスター発表,薬物動態・TDM・投与設計,臨床から学び臨床へと還元する医療薬学)

  小坂 貴子; 石渡 泰芳; 安原 眞人  日本医療薬学会年会講演要旨集  20-  428  -428  2010/10
• Delivery of gene-expressing fragments using quantum dot

  Akiyoshi Hoshino; Noriyoshi Manabe; Sanshiro Hanada; Kouki Fujioka; Masato Yasuhara; Akihiko Kondo; Kenji Yamamoto  COLLOIDAL QUANTUM DOTS FOR BIOMEDICAL APPLICATIONS IV  7189-  71890V  -71890V  2009  [Refereed]
  
• Experience of phamacokinetically guided topotecan administration for chemotherapy resistant Wilms tumor

  Aoki Yuki; Takagi Masatoshi; Maeda Yoshitika; Arai Hiromi; Takahashi Mayumi; Shibata Satoko; Isoda Takeshi; Mitsuiki Noriko; Nagasawa Masayuki; Morio Tomohiro; Yasuhara Masato; Mizutani Shuki  小児がん : 小児悪性腫瘍研究会記録  46-  (3)  337  -342  2009
• 21-P1-179 調剤薬局からフィードバックされた院外処方箋の修正内容に関する分析(薬薬連携,来るべき時代への道を拓く)

  高橋 裕; 吉田 浩美; 有野 徹; 石渡 泰芳; 成田 美代子; 武田 浩文; 成田 早織; 大山 由夏理; 谷 瑛子; 孫 希心; 宮田 貴代; 柴田 聡子; 遠藤 靖子; 加藤 能子; 松尾 次平; 片倉 義介; 根津 雅和; 安原 眞人  日本医療薬学会年会講演要旨集  18-  404  -404  2008/09
• 30-P2-42 モキシフロキサシンのラット血糖値に及ぼす影響(副作用・有害事象,社会の期待に応える医療薬学を)

  石渡 泰芳; 高橋 裕; 安原 眞人  日本医療薬学会年会講演要旨集  17-  331  -331  2007/09
• 01-D-10 レボフロキサシンによるラット血糖値上昇のメカニズム(有害事象・副作用(基礎と臨床),医療薬学の扉は開かれた)

  石渡 泰芳; 糸賀 禎恵; 安原 眞人  日本医療薬学会年会講演要旨集  16-  336  -336  2006/09
• P-176 レボフロキサシンによる痙攣のファーマコダイナミクスに及ぼすガンシクロビルの影響(7.薬物相互作用(基礎と臨床)1,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)

  糸賀 禎恵; 孫 希心; 石渡 泰芳; 安原 眞人  日本医療薬学会年会講演要旨集  15-  272  -272  2005/09
• Simultaneous multicolor detection system of the single-molecular microbial antigen by total internal reflection fluorescence microscopy with Fluorescent nanocrystal quantum dots

  Akiyoshi Hoshino; Kouki Fujioka; Mayu Yamamoto; Noriyoshi Manabe; Masato Yasuhara; Kazuo Suzuki; Kenji Yamamoto  Proceedings of SPIE - The International Society for Optical Engineering  6009-  60090P  -60090P  2005  [Refereed]
  
• Fluorescent labeling of cells and biomolecules with nanocrystal quantum dots

  A Hoshino; K Fujioka; M Suga; YF Sasaki; T Ohta; M Yasuhara; T Dohi; K Suzuki; K Yamamoto  Nanobiophotonics and Biomedical Applications II  5705-  263  -271  2005  [Refereed]
  
• P-168 ラットにおけるレボフロキサシンの中枢毒性に関するファーマコダイナミックスと腎障害の影響(9.薬物動態(基礎と臨床),"薬剤師がつくる薬物治療"-薬・薬・学の連携-)

  孫 希心; 石渡 泰芳; 安原 眞人  日本医療薬学会年会講演要旨集  14-  258  -258  2004/09
• O-119 診療情報データを利用したチクロピジンの適性使用状況および副作用に関する調査

  高橋 弘充; 廣瀬 藍子; 安原 眞人; 高瀬 浩造; 平田 浩司  日本医療薬学会年会講演要旨集  11-  108  -108  2001/09
• P-167 電子化パスシステムを利用した抗がん剤のプロトコールチェックとその評価

  松井 美奈子; 鏑木 真理子; 高橋 弘充; 安原 眞人; 神山 潤  日本医療薬学会年会講演要旨集  11-  152  -152  2001/09
• セフォセリス及びセファゾリンによる中枢毒性のファーマコダイナミックスと腎障害の影響

  永田 将司; 藤近 拓弥; 安原 眞人  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan  61-  143  -143  2001/03
• P-303 「治験実施管理システム Ver.2」と治験情報交換のための電子化標準書式 V2.0

  高橋 弘充; 安原 眞人; 高瀬 浩造; 折井 孝男; 伊賀 立二  日本病院薬学会年会講演要旨集  10-  306  -306  2000/09
• Effect of acute renal failure on the disposition of cefoperazone

  Katayama Hirokazu; Yasuhara Masato; Hori Ryohei  Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University  18-  95  -96  2000
• 25-03-07 治験実施管理システムにおける MedDRA/J を組み込んだ有害事象報告システム

  高橋 弘充; 高瀬 浩造; 安原 眞人; 折井 孝男; 伊賀 立二  日本病院薬学会年会講演要旨集  9-  60  -60  1999/08
• 26-03-14 自動注射薬払い出しシステム導入とその評価

  松井 美奈子; 高橋 弘充; 葛西 久仁子; 青柳 繁; 日置 絵里香; 佐瀬 裕子; 猪爪 信夫; 小林 悟; 安原 眞人  日本病院薬学会年会講演要旨集  9-  140  -140  1999/08
• 腎不全患者における高リン血症に対する炭酸カルシウムの効果

  久 昌勝; 青柳 繁; 高橋 弘充; 猪爪 信夫; 安原 眞人; 田村 博之; 秋葉 隆; 丸茂 文昭; 越前 宏俊  日本薬学会年会要旨集  119年会-  (4)  155  -155  1999/03
• アザセトロンの立体選択的測定法の開発

  猪爪 信夫; 大伴 武司; 安原 眞人  日本薬学会年会要旨集  116年会-  (4)  239  -239  1996/03
• VmaxおよびKmの推定偏差:シミュレーションによる母集団解析モデルの評価

  大槻 祐子; 橋本 征也; 高野 幹久; 乾 賢一; 安原 眞人; 堀 了平  薬物動態 = Xenobiotic metabolism and disposition  10-  357  -357  1995/10
• Studies of Improvement on the Preparation of Disinfectants Development of the Open-top Screw-cap

  TAKAYAMA AKIRA; KUNIMASA JUN-ICHI; ODANI ATSUKO; YASUHARA MASATO; KIMURA MICHIO; HORI RYOHEI  病院薬学  19-  (5)  458  -463  1993
• TRANSPORT MECHANISMS OF BESTATIN IN INTESTINAL AND RENAL BRUSH-BORDER MEMBRANES

  TOMITA Yoshiko; KATSURA Toshiya; OKANO Tomonobu; TAKANO Mikihisa; YASUHARA Masato; INUI Kenichi; HORI Ryohei  Journal of pharmacobio-dynamics  14-  (3)  "s  -60"  1991/03
• MEAN RESIDENCE TIME IN ORGANS IN TOXICOKINETIC STUDIES

  TANIGAWARA Yusuke; HE YanLing; AIBA Tetsuya; YASUHARA Masato; HORI Ryohei; HIROUCHI Yasukuni; NAGANUMA Hideo; KAWAHARA Yukinori; OKADA Ryuzo  Journal of pharmacobio-dynamics  14-  (2)  "s  -40"  1991/02
• PROTECTIVE EFFECT OF N-ACYL AMINO ACID DERIVATIVES ON CEPHALORIDINE NEPHROTOXICITY IN RABBITS

  HIROUCHI Yasukuni; NAGANUMA Hideo; KAWAHARA Yukinori; OKADA Ryuzo; OHOKA Koh; TANIGAWARA Yusuke; YASUHARA Masato; KAMIYA Akira; INUI Kenichi; HORI Ryohei  Journal of pharmacobio-dynamics  13-  (4)  "s  -79"  1990/04
• 2B3-14 ACTH療法によるバルプロ酸血中濃度の変動について

  伊藤 正利; 奥野 武彦; 三河 春樹; 安原 真人; 矢野 育子; 谷川原 祐介; 堀 了平  日本てんかん学会プログラム・抄録集  (24)  214  -214  1990
• Pharmacodynamic Aspects of Therapeutic Drug Monitoring

  YASUHARA MASATO; HORI RYOHEI  病院薬学  16-  (2)  71  -80  1990
• PHARMACOKINETICS AND PHARMACODYNAMICS OF AJMALINE IN DISEASE STATES

  YASUHARA Masato; HASHIMOTO Yukiya; OKUMURA Katsuhiko; HORI Ryohei  Journal of pharmacobio-dynamics  12-  (3)  "s  -40"  1989/03
• Reduced Hepatic Uptake of Propranolol in Rats With Acute Renal Failure(Abstracts of the Reports Published in 1986)

  HORI Ryohei; OKAUMURA Katsuhiko; YASUHARA Masato; KATAYAMA Hirokazu  Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University  4-  101  -102  1986
• Influenceof Acute Renal Failure on Pharmacokinetics of Phenolsulfonphthalein in Rats : A Comparative Study in vivo and in the Simultaneous Perfusion System of Liver and Kidney(Abstracts of the Reports Published in 1986)

  YASUHARA Masato; KATAYAMA Hirokazu; FUJIWARA Junko; OKUMURA Katsuhiko; HORI Ryohei  Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University  4-  99  -100  1986
• Population Pharmacokineticsに基づく薬物血中濃度の予測と処方設計 : 「薬物の体液中濃度測定と処方設計」(<特集>病院薬局協議会)

  安原 眞人; 橋田 亨; 越川 富雄; 奥村 勝彦; 堀 了平  病院薬学  11-  (2)  171  -174  1985
• PHARMACOKINETIC DRUG-INTERACTIONS IN ANTIARRHYTHMIC DRUG-THERAPY

  R HORI; K OKUMURA; M YASUHARA  PHARMACY INTERNATIONAL  6-  (2)  37  -40  1985
• POTENTIATION MECHANISM OF AJMALINE AND PROPRANOLOL ACTION BY QUINIDINE COADMINISTRATION

  YASUHARA MASATO; YATSUZUKA ATSUSHI; YAMADA KAZUSHI; OKUMURA KATSUHIKO; HORI RYOHEI; SAKURAI TSUNETARO; KAWAI CHUICHI  Journal of pharmacobio-dynamics  6-  (4)  "s  -77"  1983/04
• IN VIVO FORMATION OF HIGH MOLECULAR WEIGHT COMPONENTS FROM PEPTIDE DRUGS

  SAITO YOSHIHIRO; YASUHARA MASATO; OKUMURA KATSUHIKO; HORI RYOHEI  Journal of pharmacobio-dynamics  5-  (5)  "S  -72"  1982/05
• 1-II-10 α-Tocopherolの静脈内投与に関する研究 : 日本ビタミン学会第33回大会研究発表要旨

  谷村 弘; 加藤 仁司; 三木 毅一郎; 小林 辰章; 日笠 頼則; 安原 真人; 岩崎 優子; 北沢 式文; 堀 了平  ビタミン  55-  (7)  331  -332  1981/07

Awards & Honors

• 2015 日本医療薬学会 功績賞
   

  受賞者: 安原 眞人
• 2012 日本薬剤学会賞
   

  受賞者: 安原 眞人
• 1992 日本薬物動態学会奨励賞
   JPN

Research Grants & Projects

• Kinetics of drug-induced dysglycemia

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2015/03 

  Author : YASUHARA Masato; NAGATA Masashi
• Kinetics of Dysglycemia Induced by New Quinolone Antibiotics

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2009 -2011 

  Author : YASUHARA Masato
• Research on Organ Correlation of Drug Metabolic Activities by Gene Technology

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1999 -2000 

  Author : YASUHARA Masato
• Kinetics of Renal Disposition and Action of Bioactive Peptides

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1997 -1998 

  Author : YASUHARA Masato
• ドラッグデリバリーの空間的・時間的制御

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1996 -1996 

  Author : 橋田 充; 片岡 一則; 井上 正康; 安原 眞人; 寺崎 哲也; 前田 浩
• Population Analysis of Pharmacokinetics and Pharmacodynamics of an Immunosuppresive Agent

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1994 -1995 

  Author : YASUHARA Masato; HASHIMOTO Yukiya
• ドラッグデリバリーの空間的・時間的制御

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1994 -1994 

  Author : 橋田 満; 井上 正康; 安原 眞人; 寺崎 哲也; 前田 浩; 中尾 一和
• Kinetics of Rena1 Dispositon and Pharmacological Effect of Peptides

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1992 -1993 

  Author : YASUHARA Masato; OKUDA Masahiro; HE Yan-Ling
• Scientific Basis of Drug Disposition in the Kidney and its Application to Clinical Dosage Regimens.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1991 -1992 

  Author : HORI Ryohei; HE Yan-ling; TAKANO Mikihisa; TANIGAWARA Yusuke; YASUHARA Masato
• Pharmacokinetics and Pharmacodynamics of Antiarrhythmic Drugs in Disease State

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1987 -1989 

  Author : HORI Ryohei; SAKURAI Tunetaro; TANIGAWARA Yusuke; YASUHARA Masato; KAMIYA Akira; INUI Ken-ichi
• Application of population pharmacokinetics to the individualization of drug dosage regimen.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1985 -1986 

  Author : HORI Ryohei; TANIGAWARA Yusuke; IWAKAWA Seigo; YASUHARA Masato; KAMIYA Akira; OKUMURA Katsuhiko
• 病態による受容体レベルの変動とβ-遮断薬の薬効

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1984 -1984 

  Author : 安原 眞人
• 受容体レベルを指標とするβ‐遮断薬の Pharmacodynamics

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1983 -1983 

  Author : 安原 眞人
• 治療薬物モニタリングに基づく臨床薬物動態解析
• 病態時における薬物体内動態と薬効
• Pharmacokinetics and Pharmacodynamics in Disease States