Morikawa Masato

Researcher Information

Affiliation

Advanced Comprehensive Research Organization (ACRO) Associate Professor

Degree

• Ph.D. in Medicine（2011/03 The University of Tokyo）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201601004710108292

Research funding number

• 80775833

Researcher ID

• D-1932-2011

J-Global ID

• 201601004710108292

Research Areas

• Life sciences / Tumor biology
• Life sciences / Medical biochemistry
• Life sciences / Pathobiochemistry
• Life sciences / Experimental pathology

Academic & Professional Experience

• 2022/04 - Today  Teikyo UniversityAdvanced Comprehensive Research OrganizationAssociate Professor
• 2016/01 - 2022/03  The University of TokyoGraduate School of MedicineAssistant Professor
• 2012/04 - 2015/12  Uppsala UniversityLudwig Institute for Cancer ResearchPost-doctoral fellow
• 2011/04 - 2012/03  The University of TokyoGraduate School of MedicineProject Assistant Professor

Education

• 2007/04 - 2011/03  The University of Tokyo  Graduate School of Medicine
• 1998/04 - 2004/03  The University of Tokyo  Faculty of Medicine  School of Medicine

Association Memberships

• 日本内科学会   THE MOLECULAR BIOLOGY SOCIETY OF JAPAN   THE JAPANESE BIOCHEMICAL SOCIETY   THE JAPANESE CANCER ASSOCIATION   

Research Activity Information

Published Papers

• MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes

  Tomohiro Ogami; Yusuke Tamura; Kim Toss; Keiko Yuki; Masato Morikawa; Shuichi Tsutsumi; Hiroyuki Aburatani; Keiji Miyazawa; Kohei Miyazono; Daizo Koinuma

  The Journal of Biochemistry Oxford University Press (OUP) 171 (4) 399 - 410 0021-924X 2022/03 [Refereed]
  
• PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma‐initiating cell properties via DNA methyltransferase 3A

  Ryo Tanabe; Kohei Miyazono; Tomoki Todo; Nobuhito Saito; Caname Iwata; Akiyoshi Komuro; Satoshi Sakai; Erna Raja; Daizo Koinuma; Masato Morikawa; Bengt Westermark; Carl‐Henrik Heldin

  Molecular Oncology Wiley 16 (1) 269 - 288 1574-7891 2022/01 [Refereed]
  
• Preparation of monovalent follistatin-like 3-Fc-fusion protein and evaluation of its effects on muscle mass in mice.

  Masato Morikawa

  STAR protocols 2 (4) 100839  2021/12 [Refereed]
  
• Anti‐pyroptotic function of TGF‐β is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells

  Yusuke Tamura; Masato Morikawa; Ryo Tanabe; Kohei Miyazono; Daizo Koinuma

  Molecular Oncology Wiley 15 (5) 1289 - 1307 1574-7891 2021/05 [Refereed]
  
• Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice

  Takayuki Ozawa; Masato Morikawa; Yasuyuki Morishita; Kazuki Ogikubo; Fumiko Itoh; Daizo Koinuma; Per-Åke Nygren; Kohei Miyazono

  iScience Elsevier {BV} 24 (5) 102488 - 102488 2589-0042 2021/05 [Refereed]
  
• BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

  Yuhei Yahiro; Shingo Maeda; Masato Morikawa; Daizo Koinuma; Go Jokoji; Toshiro Ijuin; Setsuro Komiya; Ryoichiro Kageyama; Kohei Miyazono; Noboru Taniguchi

  Bone Research Springer Science and Business Media LLC 8 (1) 32 - 32 2020/12 [Refereed]
  
• TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness.

  Masato Morikawa

  Oncogene Springer Science and Business Media {LLC} 39 (22) 4436 - 4449 0950-9232 2020/04 [Refereed]
  
• Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer.

  Masato Morikawa

  Molecular oncology Wiley 14 (2) 277 - 293 1574-7891 2019/12 [Refereed]
  
• The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

  Masato Morikawa; Yoshihide Mitani; Katarina Holmborn; Taichi Kato; Daizo Koinuma; Junko Maruyama; Eleftheria Vasilaki; Hirofumi Sawada; Mai Kobayashi; Takayuki Ozawa; Yasuyuki Morishita; Yasumasa Bessho; Shingo Maeda; Johan Ledin; Hiroyuki Aburatani; Ryoichiro Kageyama; Kazuo Maruyama; Carl-Henrik Heldin; Kohei Miyazono

  Science Signaling American Association for the Advancement of Science ({AAAS}) 12 (607) eaay4430 - eaay4430 1945-0877 2019/11 [Refereed]
  
• Tyrosine kinase Eph receptor A6 sensitizes glioma‐initiating cells towards bone morphogenetic protein‐induced apoptosis

  Erna Raja; Masato Morikawa; Jun Nishida; Ryo Tanabe; Kei Takahashi; Howard J. Seeherman; Nobuhito Saito; Tomoki Todo; Kohei Miyazono

  Cancer Science Wiley 110 (11) 3486 - 3496 1347-9032 2019/11 [Refereed]
  
• EGFL7 Mediates BMP9-Induced Sprouting Angiogenesis of Endothelial Cells Derived from Human Embryonic Stem Cells.

  Masato Morikawa

  Stem cell reports Elsevier BV 12 (6) 1250 - 1259 2213-6711 2019/05 [Refereed]
  
• Palbociclib enhances activin-SMAD-induced cytostasis in estrogen receptor-positive breast cancer

  Mayumi Harada; Masato Morikawa; Takayuki Ozawa; Mai Kobayashi; Yusuke Tamura; Kei Takahashi; Masahiko Tanabe; Keiichiro Tada; Yasuyuki Seto; Kohei Miyazono; Daizo Koinuma

  Cancer Science Wiley 110 (1) 209 - 220 1347-9032 2019/01 [Refereed]
  
• TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling

  Natsumi Kawasaki; Kazunobu Isogaya; Shingo Dan; Takao Yamori; Hiroshi Takano; Ryoji Yao; Yasuyuki Morishita; Luna Taguchi; Masato Morikawa; Carl-Henrik Heldin; Tetsuo Noda; Shogo Ehata; Kohei Miyazono; Daizo Koinuma

  Cell Discovery Springer Science and Business Media LLC 4 (1) 1 - 1 2018/12 [Refereed]
  
• Intracellular and extracellular TGF-β signaling in cancer: some recent topics.

  Masato Morikawa

  Frontiers of medicine Springer Science and Business Media LLC 12 (4) 387 - 411 2095-0217 2018/07 [Refereed]
  
• Identification of a novel fusion gene HMGA2-EGFR in glioblastoma

  Akiyoshi Komuro; Erna Raja; Caname Iwata; Manabu Soda; Kazunobu Isogaya; Keiko Yuki; Yasushi Ino; Masato Morikawa; Tomoki Todo; Hiroyuki Aburatani; Hiromichi Suzuki; Melissa Ranjit; Atsushi Natsume; Akitake Mukasa; Nobuhito Saito; Hitoshi Okada; Hiroyuki Mano; Kohei Miyazono; Daizo Koinuma

  International Journal of Cancer Wiley 142 (8) 1627 - 1639 0020-7136 2018/04 [Refereed]
  
• JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

  Masato Morikawa

  Nucleic acids research Oxford University Press (OUP) 46 (3) 1180 - 1195 0305-1048 2018/02 [Refereed]
  
• ZEB1-regulated inflammatory phenotype in breast cancer cells

  Akihiro Katsura; Yusuke Tamura; Satoshi Hokari; Mayumi Harada; Masato Morikawa; Tsubasa Sakurai; Kei Takahashi; Anna Mizutani; Jun Nishida; Yuichiro Yokoyama; Yasuyuki Morishita; Takashi Murakami; Shogo Ehata; Kohei Miyazono; Daizo Koinuma

  Molecular Oncology Wiley 11 (9) 1241 - 1262 1574-7891 2017/09 [Refereed]
  
• Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.

  Masato Morikawa

  Oncogene Springer Science and Business Media LLC 36 (35) 4963 - 4974 0950-9232 2017/05 [Refereed]
  
• Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.

  Masato Morikawa

  Science signaling American Association for the Advancement of Science (AAAS) 9 (442) ra84 - ra84 1945-0877 2016/08 [Refereed]
  
• TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology.

  Masato Morikawa

  Cold Spring Harbor perspectives in biology Cold Spring Harbor Laboratory 8 (5) a021873 - a021873 1943-0264 2016/05 [Refereed]
  
• RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.

  Masato Morikawa

  Oncogene Springer Science and Business Media LLC 35 (38) 5000 - 5009 0950-9232 2016/02 [Refereed]
  
• BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors

  Masato Morikawa; Daizo Koinuma; Anna Mizutani; Natsumi Kawasaki; Katarina Holmborn; Anders Sundqvist; Shuichi Tsutsumi; Tetsuro Watabe; Hiroyuki Aburatani; Carl-Henrik Heldin; Kohei Miyazono

  Stem Cell Reports Elsevier BV 6 (1) 64 - 73 2213-6711 2016/01 [Refereed]
  
• Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells.

  Masato Morikawa

  Cancer science Wiley 105 (8) 974 - 982 1347-9032 2014/07 [Refereed]
  
• Genome-wide mechanisms of Smad binding.

  Masato Morikawa

  Oncogene Springer Science and Business Media LLC 32 (13) 1609 - 1615 0950-9232 2012/05 [Refereed]
  
• Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence.

  Masato Morikawa

  PLoS genetics Public Library of Science (PLoS) 7 (11) e1002359 - e1002359 1553-7390 2011/11 [Refereed]
  
• Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1

  Yasuhiro Yoshimatsu; Tomoko Yamazaki; Hajime Mihira; Taichi Itoh; Junichi Suehiro; Keiko Yuki; Kaori Harada; Masato Morikawa; Caname Iwata; Takashi Minami; Yasuyuki Morishita; Tatsuhiko Kodama; Kohei Miyazono; Tetsuro Watabe

  Journal of Cell Science The Company of Biologists 124 (16) 2753 - 2762 0021-9533 2011/08 [Refereed]
  
• Cell Type-specific Target Selection by Combinatorial Binding of Smad2/3 Proteins and Hepatocyte Nuclear Factor 4α in HepG2 Cells*

  Anna Mizutani; Daizo Koinuma; Shuichi Tsutsumi; Naoko Kamimura; Masato Morikawa; Hiroshi I. Suzuki; Takeshi Imamura; Kohei Miyazono; Hiroyuki Aburatani

  Journal of Biological Chemistry Elsevier BV 286 (34) 29848 - 29860 0021-9258 2011/08 [Refereed]
  
• ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.

  Masato Morikawa

  Nucleic acids research Oxford University Press (OUP) 39 (20) 8712 - 8727 0305-1048 2011/07 [Refereed]
  
• Bone morphogenetic protein receptors and signal transduction

  K. Miyazono; Y. Kamiya; M. Morikawa

  Journal of Biochemistry Oxford University Press (OUP) 147 (1) 35 - 51 0021-924X 2010/01 [Refereed]
  
• Lymphomatoid granulomatosis involving central nervous system successfully treated with rituximab alone.

  Masato Morikawa

  Archives of neurology American Medical Association (AMA) 65 (5) 0003-9942 2008/05 [Refereed]
  
• Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.

  Masato Morikawa

  Journal of virology American Society for Microbiology 78 (13) 7186 - 7198 0022-538X 2004/07 [Refereed]
  

MISC

• エピゲノム変化を介したトリプルネガティブ乳がん高悪性化機構の解明(Elucidation of the mechanisms of epigenetic change-mediated malignant transformation of triple-negative breast cancer)

  荻窪 一貴; 西田 純; 高橋 恵生; 森川 真大; 江幡 正悟; 鯉沼 代造; 宮園 浩平  日本癌学会総会記事  82回-  1604  -1604  2023/09
• エピゲノム変化を介したトリプルネガティブ乳がん高悪性化機構の解明(Elucidation of the mechanisms of epigenetic change-mediated malignant transformation of triple-negative breast cancer)

  荻窪 一貴; 西田 純; 高橋 恵生; 森川 真大; 江幡 正悟; 鯉沼 代造; 宮園 浩平  日本癌学会総会記事  82回-  1604  -1604  2023/09
• Development of FSTL3-based therapeutics as a selective antagonist of activin and myostatin

  森川真大; 宮園浩平  月刊メディカル・サイエンス・ダイジェスト  49-  (11)  2023
• PolyI:C attenuates TGF-β signaling to induce pyroptotic and cytostatic programs in triple-negative breast cancer

  鯉沼代造; 田村佑介; 森川真大; 森川真大; 堤修一; 田邉諒; 田邉諒; 宮園浩平; 宮園浩平  日本癌学会学術総会抄録集(Web)  81st-  2022
• Identification of the mechanisms of malignant progression of triple-negative breast cancer via epigenetic changes

  荻窪一貴; 西田純; 西田純; 高橋恵生; 高橋恵生; 森川真大; 森川真大; 江幡正悟; 江幡正悟; 鯉沼代造; 宮園浩平  日本癌学会学術総会抄録集(Web)  81st-  2022
• トリプルネガティブ乳がんの転移能に寄与する遺伝子とその発現制御機構の同定

  荻窪一貴; 田村佑介; 田村佑介; 西田純; 高橋恵生; 高橋恵生; 森川真大; 江幡正悟; 鯉沼代造; 宮園浩平  日本癌学会学術総会抄録集(Web)  80th-  2021
• Therapeutic potency and mechanisms of polyI:C in the treatment of triple negative breast cancer

  田村佑介; 森川真大; 田邉諒; 鯉沼代造; 宮園浩平  日本薬学会年会要旨集(Web)  141st-  2021
• 小細胞肺癌細胞と非小細胞肺癌細胞におけるTTF-1結合領域の比較解析

  穂苅 諭; 田村 佑介; 金田 篤志; 桂 彰宏; 森川 真大; 江幡 正悟; 堤 修一; 石川 雄一; 油谷 浩幸; 菊地 利明; 宮園 浩平; 鯉沼 代造  日本癌学会総会記事  79回-  OJ5  -2  2020/10
• 小細胞肺癌細胞と非小細胞肺癌細胞におけるTTF-1結合領域の比較解析

  穂苅 諭; 田村 佑介; 金田 篤志; 桂 彰宏; 森川 真大; 江幡 正悟; 堤 修一; 石川 雄一; 油谷 浩幸; 菊地 利明; 宮園 浩平; 鯉沼 代造  日本癌学会総会記事  79回-  OJ5  -2  2020/10
• 肺小細胞癌細胞におけるTTF‐1結合領域の網羅的解析

  穂苅諭; 穂苅諭; 森川真大; 桂彰宏; 田村佑介; 村井文彦; 江幡正悟; 菊地利明; 鯉沼代造; 宮園浩平  日本呼吸器学会誌(Web)  8-  162  2019/03
• 肺癌 基礎 肺小細胞癌細胞におけるTTF-1結合領域の網羅的解析

  穂苅 諭; 森川 真大; 桂 彰宏; 田村 佑介; 村井 文彦; 江幡 正悟; 菊地 利明; 鯉沼 代造; 宮園 浩平  日本呼吸器学会誌  8-  (増刊)  162  -162  2019/03
• Tyrosine kinase EPH Receptor A6 sensitizes glioblastoma cells towards Bone Morphogenetic Protein-induced apoptosis

  森川真大; RAJA Erna; 宮園浩平  日本癌学会学術総会抄録集(Web)  78th-  2019
• ホルモン受容体陽性乳がんにおけるPalbociclibのActivin-SMADシグナルへの影響

  原田真悠水; 原田真悠水; 森川真大; 田辺真彦; 西岡琴江; 丹羽隆善; 佐藤綾花; 尾辻和尊; 森園亜里紗; 崎山香奈; 大矢真里子; 小西孝明; 林香菜子; 倉林理恵; 山村純子; 鯉沼代造; 宮園浩平; 瀬戸泰之; 瀬戸泰之  日本乳癌学会学術総会プログラム・抄録集  27th-  2019
• TUFT1-RABAP1を介した小胞輸送制御によるmTORC1シグナルの新規活性化機構の解析

  川崎 夏実; 磯谷 一暢; 旦 慎吾; 矢守 隆夫; 高野 洋志; 八尾 良司; 田口 瑠奈; 森川 真大; 野田 哲生; 江幡 正悟; 宮園 浩平; 鯉沼 代造  日本癌学会総会記事  76回-  J  -2067  2017/09
• TUFT1は核周囲への小胞の集積を促進しmTORC1を活性化する

  川崎 夏実; 磯谷 一暢; 旦 慎吾; 矢守 隆夫; 高野 洋志; 八尾 良司; 田口 瑠奈; 森川 真大; 野田 哲生; 江幡 正悟; 宮園 浩平; 鯉沼 代造  日本癌学会総会記事  75回-  E  -2114  2016/10
• TGF-β誘導性long non-coding RNA-Smad7はマウス乳がん細胞のアポトーシスを抑制する

  荒瀬 麻友; 堀口 華奈; 江幡 正悟; 森川 真大; 堤 修一; 油谷 浩幸; 宮園 浩平; 鯉沼 代造  日本生化学会大会プログラム・講演要旨集  87回-  [4T14a  -06]  2014/10
• 肺腺癌におけるTGF-β標的遺伝子RBM47の発現と作用機構の解析

  櫻井 翼; 鯉沼 代造; 磯谷 一暢; 坂井 慧; 森川 真大; 森下 保幸; 江幡 正悟; 宮園 浩平  日本生化学会大会プログラム・講演要旨集  87回-  [4T14a  -07]  2014/10
• 網羅解析からの血管研究アプローチ 5 血管構成細胞におけるBMPシグナルの網羅解析

  森川真大; 鯉沼代造; 宮園浩平  血管医学  14-  (4)  385  -390  2014/02
• サイトカインシグナル伝達機構 Smad経路を介したTGF‐βファミリー分子のシグナル伝達機構

  森川真大; 宮園浩平  医学のあゆみ  234-  (5)  331  -336  2010/07
• Rituximab単剤投与が有効と思われた中枢神経病変を有するLymphomatoid Granulomatosis(LYG)

  森川真大; 賀古真一; 渡辺卓郎; 伊豆津宏二; 浅井隆司; 佐藤博之; 細谷紀子; 半下石明; 神田善伸; 千葉滋; 本倉徹; 黒川峰夫; 石浦浩之; 濱田雅; 郭伸; 後藤順; 辻省次  臨床血液  47-  (5)  406  2006/05

Awards & Honors

• 2024/10 内藤記念科学振興財団 2024年度内藤記念科学奨励金・研究助成
   

  受賞者: 森川 真大
• 2023/11 Takeda Science Foundation Research Grant
   

  受賞者: 森川 真大
• 2023/11 Mochida Memorial Foundation for Medical and Pharmaceutical Research Research Grant
   

  受賞者: 森川 真大
• 2021/07 virtual FASEB Science Research Conference, The TGF-β Superfamily Conference: Signaling in Development and Disease Award for the Best Short Talk
   

  受賞者: Masato Morikawa
• 2014/05 TGF-β meeting in Leiden 2014 Best Poster Award
   

  受賞者: Masato Morikawa
• 2013/04 佐賀県 ITO Genboku and SAGARA Chian Memorial Scholarship
   

  受賞者: 森川 真大
• 2012/08 TGF-β meeting in Leiden 2012 Best Poster Award
   

  受賞者: Masato Morikawa
• 2011/05 9th Hereditary Hemorrhagic Telangiectasia (HHT) Scientific Conference Award for the Best Oral Presentation by a Young Investigator
   

  受賞者: Masato Morikawa
• 2011/02 Kanae Foundation Research Abroad
   

  受賞者: 森川 真大

Research Grants & Projects

• アクチビン・ミオスタチン阻害剤FSTL3製剤の筋萎縮症モデルでの評価

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2022/04 -2025/03 

  Author : 森川 真大
• Development of a selective inhibitor of Activin and its application in a cancer-bearing mouse model

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2019/04 -2023/03 

  Author : 森川 真大
• Molecular mechanisms of cell differentiation and diversity by TGF-beta family members

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2017/06 -2022/03 

  Author : 宮園 浩平; 鯉沼 代造; 森川 真大; 江幡 正悟
• Roles of bone morphogenetic protein (BMP) in pluripotency and tumorigenesis

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2017/04 -2019/03 

  Author : Morikawa Masato
• Exploring the role of BMP signaling in cell differentiation/cell-fate decision and plasticity

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016/08 -2018/03 

  Author : 森川 真大

Media Coverage

• ミオスタチン阻害薬をめぐる攻防、アカデミアはどこまで創薬に迫れるか

  Date : 2021/11/16

  Program, newspaper magazine: 日経バイオテク

  Internet
• 研究成果掲載：副作用なく筋肉増やす 東大など 新薬剤動物実験で確認

  Date : 2021/05/17

  Program, newspaper magazine: 読売新聞夕刊

  Paper
• 研究成果掲載：筋⾁増やす新薬、東⼤チームが開発…⾼齢者の筋⼒低下防げる可能性

  Date : 2021/05/15

  Program, newspaper magazine: 読売新聞 オンライン

  Internet
• 研究成果掲載：東⼤、新規ミオスタチン阻害薬である1価FSTL3-Fcを開発

  Date : 2021/05/15

  Program, newspaper magazine: 日本経済新聞 電子版

  Internet
• 研究成果掲載：肺高血圧症の新規治療法開発へ期待

  Date : 2019/11/29

  Program, newspaper magazine: 科学新聞

  Paper
• 研究成果掲載：東大と三重大など、肺動脈性肺高血圧症の疾患関連遺伝子 ATOH8を同定

  Date : 2019/11/19

  Program, newspaper magazine: 日本経済新聞 電子版

  Internet