Watanabe Takaki

Researcher Information

Affiliation

Advanced Comprehensive Research Organization (ACRO) Senior Assistant Professor

Degree

• Ph.D.(Doctor of Science)（2014/03 Nagoya University）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201501055244437138

J-Global ID

• 201501055244437138

Research Interests

• シナプス刈り込み   包括脳ネットワーク   チャネル   活動電位   シナプス   プルキンエ細胞   小脳   ゼブラフィッシュ   マウス   分子生物学   神経科学   

Research Areas

• Life sciences / Neuroscience - general

Academic & Professional Experience

• 2023/04 - Today  Advanced Comprehensive Research Organization (ACRO), Teikyo University
• 2018/04 - 2023/03  The University of TokyoGraduate School of Medicine
• 2015/02 - 2018/03  The University of TokyoGraduate School of Medicine
• 2014/04 - 2015/01  The University of TokyoGraduate School of Medicine

Association Memberships

• 日本神経科学学会   北米神経科学会   日本生理学会   

Research Activity Information

Published Papers

• PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum

  Yuto Okuno; Kazuto Sakoori; Kyoko Matsuyama; Miwako Yamasaki; Masahiko Watanabe; Kouichi Hashimoto; Takaki Watanabe; Masanobu Kano

  Frontiers in Molecular Neuroscience Frontiers Media SA 16 2023/06 [Refereed]
  
• mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning

  Maria Harbers; Harumi Nakao; Takaki Watanabe; Kyoko Matsuyama; Shoichi Tohyama; Kazuki Nakao; Yasushi Kishimoto; Masanobu Kano; Atsu Aiba

  Cells MDPI AG 11 (13) 2004 - 2004 2022/06 [Refereed]
  
• Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.

  Kazuya Toriumi; Stefano Berto; Shin Koike; Noriyoshi Usui; Takashi Dan; Kazuhiro Suzuki; Mitsuhiro Miyashita; Yasue Horiuchi; Akane Yoshikawa; Mai Asakura; Kenichiro Nagahama; Hsiao-Chun Lin; Yuki Sugaya; Takaki Watanabe; Masanobu Kano; Yuki Ogasawara; Toshio Miyata; Masanari Itokawa; Genevieve Konopka; Makoto Arai

  Redox biology 45 102057 - 102057 2021/09 [Refereed]
  
• Combining electrophysiology and optogenetics for functional screening of pyramidal neurons in the mouse prefrontal cortex

  Kenichiro Nagahama; Shuhei Fujino; Takaki Watanabe; Naofumi Uesaka; Masanobu Kano

  STAR Protocols Elsevier BV 2 (2) 100469 - 100469 2666-1667 2021/06 [Refereed]
  
• mGluR1 Is a Molecular “Hub” for Synapse Elimination in the Developing Cerebellum

  Masanobu Kano; Takaki Watanabe; Naofumi Uesaka

  Contemporary Clinical Neuroscience Springer Nature 77 - 89 2627-5341 2021
• Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex

  Hiroaki Sacai; Kazuto Sakoori; Kohtarou Konno; Kenichiro Nagahama; Honoka Suzuki; Takaki Watanabe; Masahiko Watanabe; Naofumi Uesaka; Masanobu Kano

  Nature Communications Springer Science and Business Media LLC 11 (1) 2020/12 [Refereed]
  
• AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication

  Kunihiko Yamashiro; Kei Hori; Esther S.K. Lai; Ryo Aoki; Kazumi Shimaoka; Nariko Arimura; Saki F. Egusa; Asami Sakamoto; Manabu Abe; Kenji Sakimura; Takaki Watanabe; Naofumi Uesaka; Masanobu Kano; Mikio Hoshino

  iScience Elsevier BV 101820 - 101820 2589-0042 2020/11 [Refereed]
  
• Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities.

  Kenichiro Nagahama; Kazuto Sakoori; Takaki Watanabe; Yusuke Kishi; Keita Kawaji; Michinori Koebis; Kazuki Nakao; Yukiko Gotoh; Atsu Aiba; Naofumi Uesaka; Masanobu Kano

  Cell reports 32 (11) 108126 - 108126 2020/09 [Refereed]
  
• Impairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and schizophrenia-like behavioral deficits

  Kazuya Toriumi; Stefano Berto; Shin Koike; Noriyoshi Usui; Takashi Dan; Kazuhiro Suzuki; Mitsuhiro Miyashita; Yasue Horiuchi; Akane Yoshikawa; Yuki Sugaya; Takaki Watanabe; Mai Asakura; Masanobu Kano; Yuki Ogasawara; Toshio Miyata; Masanari Itokawa; Genevieve Konopka; Makoto Arai

  Cold Spring Harbor Laboratory 2020/07 [Refereed]
  
• A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders.

  Toshimitsu Suzuki; Toshifumi Suzuki; Matthieu Raveau; Noriko Miyake; Genki Sudo; Yoshinori Tsurusaki; Takaki Watanabe; Yuki Sugaya; Tetsuya Tatsukawa; Emi Mazaki; Atsushi Shimohata; Itaru Kushima; Branko Aleksic; Tomoko Shiino; Tomoko Toyota; Yoshimi Iwayama; Kentaro Nakaoka; Iori Ohmori; Aya Sasaki; Ken Watanabe; Shinichi Hirose; Sunao Kaneko; Yushi Inoue; Takeo Yoshikawa; Norio Ozaki; Masanobu Kano; Takeyoshi Shimoji; Naomichi Matsumoto; Kazuhiro Yamakawa

  Annals of clinical and translational neurology 7 (7) 1117 - 1131 2020/07 [Refereed]
  
• Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum

  Yurie Rai; Takaki Watanabe; Kyoko Matsuyama; Kenji Sakimura; Naofumi Uesaka; Masanobu Kano

  Neuroscience Elsevier BV 0306-4522 2020/04 [Refereed]
  
• Developmental synapse remodeling in the cerebellum and visual thalamus

  Masanobu Kano; Takaki Watanabe

  F1000Research F1000 Research Ltd 8 1191 - 1191 2019/07 [Refereed]
  
• Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.

  Kano M; Watanabe T; Uesaka N; Watanabe M

  Cerebellum 2018/07 [Refereed]
  
• Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice.

  Kikuchihara S; Sugio S; Tanaka KF; Watanabe T; Kano M; Yamazaki Y; Watanabe M; Ikenaka K

  J Neurochem 2018/06 [Refereed]
  
• Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.

  Naofumi Uesaka; Manabu Abe; Kohtarou Konno; Maya Yamazaki; Kazuto Sakoori; Takaki Watanabe; Tzu-Huei Kao; Takayasu Mikuni; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano

  Neuron 97 (4) 796 - 805 2018/02 [Refereed]
  
• Coordinated expression of two types of low-threshold K+ channels establishes unique single spiking of mauthner cells among segmentally homologous neurons in the zebrafish hindbrain

  Takaki Watanabe; Takashi Shimazaki; Yoichi Oda

  eNeuro Society for Neuroscience 4 (5) 2373-2822 2017/09 [Refereed]
  
• Alternative splicing in the C-terminal tail of Ca(v)2.1 is essential for preventing a neurological disease in mice

  Tomonori Aikawa; Takaki Watanabe; Taisuke Miyazaki; Takayasu Mikuni; Minoru Wakamori; Miyano Sakurai; Hidenori Aizawa; Nobutaka Ishizu; Masahiko Watanabe; Masanobu Kano; Hidehiro Mizusawa; Kei Watase

  HUMAN MOLECULAR GENETICS 26 (16) 3094 - 3104 0964-6906 2017/08 [Refereed]
  
• Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.

  Kano M; Watanabe T

  F1000Res. 6 (416) 2017/04 [Refereed]
  
• Mechanisms of synapse pruning in the developing cerebellum

  Takaki Watanabe; Naofumi Uesaka; Masanobu Kano

  Seikagaku Japanese Biochemical Society 88 (5) 621 - 629 2189-0544 2016 [Refereed]
  
• Coexpression of auxiliary K-v beta 2 subunits with K(v)1.1 channels is required for developmental acquisition of unique firing properties of zebrafish Mauthner cells

  Takaki Watanabe; Takashi Shimazaki; Aoba Mishiro; Takako Suzuki; Hiromi Hirata; Masashi Tanimoto; Yoichi Oda

  JOURNAL OF NEUROPHYSIOLOGY 111 (6) 1153 - 1164 0022-3077 2014/03 [Refereed]
  
• Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease

  Hiromi Hirata; Takaki Watanabe; Jun Hatakeyama; Shawn M. Sprague; Louis Saint-Amant; Ayako Nagashima; Wilson W. Cui; Weibin Zhou; John Y. Kuwada

  DEVELOPMENT 134 (15) 2771 - 2781 0950-1991 2007/08 [Refereed]
  

MISC

• 小脳の生後発達におけるシナプス刈り込みの分子基盤

  野呂 高之, 渡邉 貴樹, 狩野 方伸  生体の科学  74-  (1)  2023/02
• 発達期シナプス刈り込みの細胞・分子機構

  赤松翼, 鈴木穂香, 渡邉貴樹, 狩野方伸  月刊細胞 (細胞)  50-  (14)  727  -730  2018/12
• 小脳登上線維-プルキンエ細胞間シナプスの精緻化へのグリア細胞の関与

  菊地原 沙織; 杉尾 翔太; 稲村 直子; 渡辺 雅彦; 田中 謙二; 渡邉 貴樹; 狩野 方伸; 山崎 良彦; 池中 一裕  日本生理学雑誌  79-  (1)  23  -23  2017/02
• 生後発達期の小脳におけるシナプス刈り込みのメカニズム

  渡邉 貴樹; 上阪 直史; 狩野 方伸  生化学  88-  (5)  621  -629  2016
• Molecular basis for developmental acquisition of unique firing property of Mauthner cell in zebrafish

  Takaki Watanabe; Takashi Shimazaki; Takako Suzuki; Masashi Tanimoto; Hiromi Hirata; Yoichi Oda  NEUROSCIENCE RESEARCH  71-  E84  -E84  2011
• Molecular basis for unique firing property of Mauthner cell in zebrafish

  Takaki Watanabe; Takako Suzuki; Masashi Tanimoto; Hiromi Hirata; Yoichi Oda  NEUROSCIENCE RESEARCH  68-  E111  -E111  2010
• Molecular basis underlying developmental change in firing properties of zebrafish Mauthner cell

  Takaki Watanabe; Takako Suzuki; Masashi Tanimoto; Hiromi Hirata; Yoichi Oda  NEUROSCIENCE RESEARCH  65-  S137  -S137  2009

Awards & Honors

• 2019/12 「次世代脳プロジェクト」冬のシンポジウム2019 若手優秀発表賞
   

  受賞者: 渡邉 貴樹
• 2018/02 第23回グリアクラブ賞
   

  受賞者: 渡邉 貴樹

Research Grants & Projects

• A role of Pcdh10 in synapse elimination of the developing mouse cerebellum

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2019/04 -2022/03 

  Author : Watanabe Takaki
• Advanced Bioimaging Support

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016 -2021 

  Author : KANO Masanobu; Kano Masanobu; Ueno Naoto; Maruyama Megumi; Mano Shoji; Watanabe Takaki; Hiraoka Yasushi; Komoto Shinya; Miyazawa Atsuo; Sadato Norihiro; Shimanuki Mizuki; Imamura Takeshi; Nonaka Shigenori; Fujimori Toshihiko; Matsuda Michiyuki; Nabekura Junichi; Inaba Kazuo; Higashiyama Tetsuya; Nemoto Tomomi; Okada Yasushi; Furuta Toshiaki; Sugaya Yuki; Nakagaki Toshiyuki; Mitsuoka Kaoru; Sakamoto Hirotaka; Nakamura Kei-ichiro; Koike Masato; Furuse Mikio; Fukazawa Yugo; Watanabe Masahiko; Aoki Shigeki; Kasai Kiyoto; Uchida Seiichi; Yasunaga Takuo; Higaki Takumi; Oda Yoshihisa; Kimori Yoshitaka; Hasezawa Seiichiro
• 小脳全域のプルキンエ細胞特異的CRISPR/Cas9スクリーニング系の確立

  文部科学省：挑戦的萌芽研究

  Date (from‐to) : 2016/04 -2018/03 

  Author : 渡邉 貴樹
• ゼブラフィッシュの逃避行動制御機構の獲得に関する生理学的・分子生物学的研究

  日本学術振興会：特別研究員（DC１）

  Date (from‐to) : 2009 -2012 

  Author : 渡邉 貴樹