Isoo Noriko

Researcher Information

Affiliation

Preclinical Medicine Senior Assistant Professor
Department of Physiology Senior Assistant Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201301017425995872

J-Global ID

• 201301017425995872

Research Interests

• エクソソーム   病原性タンパク伝播   アルツハイマー病   運動ニューロン   GluN2Bサブユニット   NMDA受容体   皮質脊髄路   シナプス除去   シナプス可塑性   シナプス形成   

Research Areas

• Life sciences / Neurology
• Life sciences / Neuroscience - general

Academic & Professional Experience

• 2016/04 - Today  Teikyo UniversitySchool of Medicine

Association Memberships

• Society for Neuroscience   THE JAPANESE SOCIETY OF INTERNAL MEDICINE   JAPAN SOCIETY FOR DEMENTIA RESEARCH   PHYSIOLOGICAL SOCIETY OF JAPAN   THE JAPAN NEUROSCIENCE SOCIETY   JAPANESE SOCIETY OF NEUROLOGY   

Research Activity Information

Published Papers

• Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion.

  Haruaki Sato; Kensaku Kasuga; Noriko Isoo; Toshihiro Hayashi; Takeshi Ikeuchi; Yukiko Hori; Taisuke Tomita

  Neuroscience research 193 63 - 70 2023/03
• Uptake of tau-containing exosomes by neuronal cells(タイトル和訳中)

  Isoo Noriko; Kawata Kentaro; Iso-o Naoyuki; Hori Yukiko; Tomita Taisuke; Hayashi Toshihiro

  The Journal of Physiological Sciences (一社)日本生理学会 72 (Suppl.1) 123 - 123 1880-6546 2022/12
• APP依存的な新規タウ分泌現象の発見

  佐藤 玄謙; 春日 健作; 磯尾 紀子; 林 俊宏; 堀 由起子; 池内 健; 富田 泰輔

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 95回 1P - 358 2022/11
• タウ蛋白質を含むエクソソーム亜集団の同定(Identification of a subpopulation of exosomes containing tau proteins)

  Kawata Kentaro; Isoo Noriko; Iso-o Naoyuki; Hori Yukiko; Tomita Taisuke; Hayashi Toshihiro

  臨床神経学 (一社)日本神経学会 62 (Suppl.) S415 - S415 0009-918X 2022/10
• Malaria Parasites Hijack Host Receptors From Exosomes to Capture Lipoproteins

  Iso-o N; Komatsuya K; Tokumasu F; Isoo N; Ishigaki T; Yasui H; Yotsuyanagi H; Hara M; Kita K

  Frontiers in Cell and Developmental Biology Frontiers Media SA 9 2021/11 [Refereed]
  
• 特定のプール内脊髄運動ニューロンの分離 運動ニューロンにおける遺伝子発現の多様性(Isolation of spinal motoneurons of a defined pool: diversity in gene expressions of motoneurons)

  Isoo Noriko; Murabe Naoyuki; Kameda Hiroshi; Fukuda Satoshi; Ikeda Miki; Teramoto Sayaka; Hayashi Toshihiro; Kwak Shin; Sakurai Masaki

  The Journal of Physiological Sciences (一社)日本生理学会 70 (Suppl.1) S134 - S134 1880-6546 2020/03
• Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal.

  Murabe N; Mori T; Fukuda S; Isoo N; Ohno T; Mizukami H; Ozawa K; Yoshimura Y; Sakurai M

  Scientific reports 8 (1) 16536  2018/11 [Refereed]
  
• The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period

  Noriko Isoo; Takae Ohno; Mutsumi Isowaki; Satoshi Fukuda; Naoyuki Murabe; Hiroaki Mizukami; Keiya Ozawa; Masayoshi Mishina; Masaki Sakurai

  SCIENTIFIC REPORTS 6 34196  2045-2322 2016/09 [Refereed]
  
• Cerebellar tremor.

  Isoo N; Sakurai M

  Neurological Medicine 85 (1) 28 - 32 2016/07 [Invited]
  
• Corticospinal axons make direct synaptic connections with spinal motoneurons innervating forearm muscles early during postnatal development in the rat

  Hitoshi Maeda; Satoshi Fukuda; Hiroshi Kameda; Naoyuki Murabe; Noriko Isoo; Hiroaki Mizukami; Keiya Ozawa; Masaki Sakurai

  JOURNAL OF PHYSIOLOGY-LONDON 594 (1) 189 - 205 0022-3751 2016/01 [Refereed]
  
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• Cerebellar signs and symptoms, and their physiological mechanisms.

  Isoo N; Sakurai M

  Neurological Medicine 78 (6) 674 - 682 2013/06 [Invited]
  
• Single Chain Variable Fragment against Nicastrin Inhibits the gamma-Secretase Activity

  Ikuo Hayashi; Sho Takatori; Yasuomi Urano; Hiroko Iwanari; Noriko Isoo; Satoko Osawa; Maiko A. Fukuda; Tatsuhiko Kodama; Takao Hamakubo; Tong Li; Philip C. Wong; Taisuke Tomita; Takeshi Iwatsubo

  JOURNAL OF BIOLOGICAL CHEMISTRY 284 (41) 27838 - 27847 0021-9258 2009/10 [Refereed]
  
• A beta 42 overproduction associated with structural changes in the catalytic pore of gamma-secretase - Common effects of Pen-2 N-terminal elongation and fenofibrate

  Noriko Isoo; Chihiro Sato; Hiroyuki Miyashita; Mitsuru Shinohara; Nobumasa Takasugi; Yuichi Morohashi; Shoji Tsuji; Taisuke Tomita; Takeshi Iwatsubo

  JOURNAL OF BIOLOGICAL CHEMISTRY 282 (17) 12388 - 12396 0021-9258 2007/04 [Refereed]
  
• Association of active gamma-secretase complex with lipid rafts

  Y Urano; Hayashi, I; N Isoo; PC Reid; Y Shibasaki; N Noguchi; T Tomita; T Iwatsubo; T Hamakubo; T Kodama

  JOURNAL OF LIPID RESEARCH 46 (5) 904 - 912 0022-2275 2005/05 [Refereed]
  
• Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions

  M Niimura; N Isoo; N Takasugi; M Tsuruoka; K Ui- Tei; K Saigo; Y Morohashi; T Tomita; T Iwatsubo

  JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13) 12967 - 12975 0021-9258 2005/04 [Refereed]
  
• Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

  Hayashi, I; Y Urano; R Fukuda; N Isoo; T Kodama; T Hamakubo; T Tomita; T Iwatsubo

  JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36) 38040 - 38046 0021-9258 2004/09 [Refereed]
  
• Functional analysis of the presenilin complex and gamma-secretase activity

  T Tomita; N Takasugi; M Tsuruoka; M Niimura; Hayashi, I; Y Takahashi; Y Morohashi; N Isoo; S Tanaka; C Sato; T Iwatsubo

  Molecular Neurobiology of Alzheimer Disease and Related Disorders 84 - 93 2004 [Refereed]
  
• Noise-induced sensitization of human brain: Toward the neurological application of stochastic resonance

  Y Yamamoto; R Soma; Hidaka, I; D Nozaki; N Iso-o; S Kwak

  UNSOLVED PROBLEMS OF NOISE AND FLUCTUATIONS 665 234 - 241 0094-243X 2003 [Refereed]
  
• Noise-induced sensitization of human brain

  Y Yamamoto; Hidaka, I; D Nozaki; N Iso-o; R Soma; S Kwak

  PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 314 (1-4) 53 - 60 0378-4371 2002/11 [Refereed]
  
• Noise-induced compensation for postural hypotension in primary autonomic failure

  Y Yamamoto; Hidaka, I; N Iso-o; A Komai; R Soma; S Kwak

  BRAIN RESEARCH 945 (1) 71 - 78 0006-8993 2002/07 [Refereed]
  
• Hemiparkinsonism associated with a mesencephalic tumor

  M Yoshimura; T Yamamoto; N Iso-o; Imafuku, I; T Momose; Shirouzu, I; S Kwak; Kanazawa, I

  JOURNAL OF THE NEUROLOGICAL SCIENCES 197 (1-2) 89 - 92 0022-510X 2002/05 [Refereed]
  

MISC

• APP依存的な新規タウ分泌現象の発見

  佐藤 玄謙; 春日 健作; 磯尾 紀子; 林 俊宏; 堀 由起子; 池内 健; 富田 泰輔  日本生化学会大会プログラム・講演要旨集  95回-  1P  -358  2022/11
• アルツハイマー病におけるエクソソームの輸送機構の解明-治療への応用とバイオマーカー探索

  磯尾紀子; 林俊宏; 富田泰輔; 磯尾直之  三井住友海上福祉財団研究結果報告書集  25-  2021
• Isolation of defined spinal motoneuron for profiling gene expression.

  Isoo, N; Murabe, N; Fukuda, S; Teramoto, S; Hayashi, T; Kwak, S; Sakurai, M  60th Annual Meeting of the Japanese Society of Neurology,  59-  (Suppl.)  S394  -S394  2019/05
• Developmental shift of NMDA receptor subunits is essential for closing the critical period in corticospinal synapse elimination

  Takae Ohno; Mutsumi Isowaki; Noriko Isoo; Naoyuki Murabe; Hitoshi Maeda; Satoshi Fukuda; Noboru Yoshioka; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E232  -E232  2011
• Dynamics of presynaptic structures and axons in the development of corticospinal innervation in vitro: Analysis by live imaging

  Noriko Isoo; Takae Ohno; Naoyuki Murabe; Noboru Yoshioka; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E334  -E334  2011
• Developmental shift of NMDA receptor subunit component in corticospinal synapses

  Mutsumi Isowaki; Takae Ohno; Noriko Iso-o; Hitoshi Maeda; Satoshi Fukuda; Takakazu Kobayashi; Masayoshi Mishina; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E133  -E133  2011
• Long-distance retrograde movement and stabilization of synaptophysin-positive puncta along corticospinal axons during the first postnatal week in slice culture

  Noboru Yoshioka; Tomoki Miyazaki; Noriko Isoo; Naoyuki Murabe; Koji Kameda; Ichiro Takahashi; Masaki Sakurai  NEUROSCIENCE RESEARCH  71-  E119  -E119  2011
• Pen-2のN末端の延長によりAβ42産生上昇を来す機構

  磯尾 紀子; 佐藤 千尋; 宮下 紘幸; 篠原 充; 高杉 展正; 諸橋 雄一; 辻 省次; 富田 泰輔; 岩坪 威  臨床神経学  47-  (12)  1077  -1077  2007/12
• Pen-2がAβのC末端長に及ぼす影響の解析

  磯尾 紀子; 宮下 紘幸; 林 幾雄; 篠原 充; 辻 省次; 富田 泰輔; 岩坪 威  臨床神経学  46-  (12)  1132  -1132  2006/12
• ショウジョウバエ細胞を用いたγセクレターゼ構成因子及び制御因子の解析

  富田泰輔; 篠原充; 新村学; 磯尾紀子; 千々岩かりな; 一色隼人; 諸橋雄一; 岩坪威  日本痴呆学会誌  19-  (2)  2005
• Pen-2のN末端がγセクレターゼ活性に及ぼす影響の検討

  磯尾紀子; 新村学; 篠原充; 諸橋雄一; 辻省次; 富田泰輔; 岩坪威  日本神経学会総会プログラム・抄録集  46th-  2005
• γセクレターゼ構成蛋白Nicastrin,PEN-2の機能解析

  磯尾紀子; 富田泰輔; 宮岸真; 多比良和誠; 辻省次; 岩坪威  日本神経学会総会プログラム・抄録集  45th-  2004
• γセクレターゼ構成蛋白Nicastrin,PEN-2の機能解析

  磯尾紀子; 富田泰輔; 宮岸真; 多比良和誠; 辻省次; 岩坪威  臨床神経学  44-  (12)  2004
• Functional analysis of presenilin complex and gamma-secretase activity

  T Tomita; Y Takahashi; Hayashi, I; Y Morohashi; S Tanaka; N Isoo; T Watabiki; M Tsuruoka; N Takasugi; T Iwatsubo  NEUROBIOLOGY OF AGING  23-  (1)  S276  -S277  2002/07
• Effects of heart rate and blood pressure variabilities on the central baroreflex mechanisms in humans

  YAMAMOTO Yoshiharu; SOMA Rika; HIDAKA Ichiro; ISO-O Noriko; KWAK Shin  自律神経 = The Autonomic nervous system  39-  (2)  176  -183  2002/04
• γセクレターゼによる膜内配列切断におけるプレセニリン複合体の役割

  富田泰輔; 高橋宴子; 林幾雄; 鶴岡牧子; 田中さやか; 磯尾紀子; 諸橋雄一; 高杉展正; 岩坪威  生化学  74-  (8)  2002
• ショウジョウバエプレセニリン(Psn)のγ-セクレターゼ活性及び高分子量複合体形成機構に関する研究

  高杉展正; 鶴岡牧子; 田中さやか; 磯尾紀子; 諸橋雄一; 富田泰輔; 岩坪威  生化学  74-  (8)  2002

Awards & Honors

• 2019/11 武田薬品工業株式会社 COCKPI-T Funding
  
• 2019/10 帝京大学医学部 2018年度Best Teacher Award
  
• 2018/11 三井住友海上福祉財団 研究助成
  

Research Grants & Projects

• エクソソームの輸送先選択性に基づきタウの伝播阻止を目指すアルツハイマー病治療

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2022/04 -2025/03 

  Author : 磯尾 紀子
• The effect of locus coeruleus-noradrenergic dysfunction on brain environment in Alzheimer's disease

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2020/04 -2023/03 

  Author : 林 俊宏; 磯尾 紀子
• Development, plasticity, and its critical period of the corticospinal synapses

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011/04 -2014/03 

  Author : SAKURAI Masaki; YOSHIOKA Noboru; ISOO Noriko; FUKUDA Satoshi