Researchers Database

Oku Naoto

    Faculty of Pharma-Science Specially Appointed Professor
Last Updated :2023/05/11

Researcher Information


    Faculty of Pharma-Science Specially Appointed Professor


  • Ph.D(1980/11 University of Tokyo)


J-Global ID


  • 東京都世田谷区生まれ,都立戸山高校卒,東京大学薬学部卒・大学院薬学系研究科博士課程修了(薬学博士).米国ノースウエスタン大学留学後,摂南大学薬学部講師/助教授,静岡県立大学薬学部助教授/教授(薬学部長,副学長,理事,大学院薬食生命科学総合学府長歴任).元日本薬学会会頭.専門は薬物送達学.

Research Interests

  • Drug Delivery System   Life Science   drug delivery Systems   Radiobiochemistry   Medical biochemistry   

Research Areas

  • Life sciences / Clinical pharmacy
  • Life sciences / Pharmaceuticals - health and biochemistry

Academic & Professional Experience

  • 2018/04 - Today  Teikyo UniversityFaculty of Pharma-Science
  • 1998 - 2018  University of ShizuokaSchool of Pharmaceutical Sciences
  • 1991 - 1998  University of ShizuokaSchool of Pharmaceutical Sciences
  • 1991 - 1998  Associate Professor University of Shizuoka
  • 1998  - Professor University of Shizuoka
  • 1987 - 1991  Setsunan UniversityFaculty of Pharmaceutical Sciences
  • 1987 - 1991  Associate Professor Setsunan University
  • 1983 - 1987  Setsunan UniversityFaculty of Pharmaceutical Sciences
  • 1983 - 1987  Assistant Professor Setsunan University
  • 1982 - 1983  Research associate, Northwestern University
  • 1981 - 1982  Postdoctoral fellow, Northwestern University
  • 1980 - 1981  Research assistant, university of tokyo


  • 1975 - 1980  The University of Tokyo  Graduate School of Pharmaceutical Sciences
  • 1971 - 1975  The University of Tokyo  Faculty of Pharmaceutical Sciences

Association Memberships

  • 日本薬学教育学会   Control Release Society   国際リポソーム学会   日本DDS学会   日本薬学会   

Research Activity Information

Published Papers

Books etc

  • Shimizu K, Oku N: "Liposomes conjugated with a pilot molecule." pp. 187-216.
    “Cancer drug delivery systems based on the tumor microenvironment.” (Matsumura Y, Tarin D. eds.) Springer Japan. 2019
  • Koide H, Asai T, Shimizu K, Oku N: "Drug carrier systems for anticancer agents." pp. 153-169.
    “Polymeric Biomaterials: Medical and Pharmaceutical Applications, Volume 2” (Dumitriu S, Popa V. Eds.) CRC Press, Taylor and Francis Group, Boca Raton, FL. 2013
  • Shimizu K, Oku N: "Brain tumor diagnosis using PET with angiogenic vessel-targeting liposomes." pp. 169-176.
    “Tumor of the central nervous system, Volume 3” (Hayat MA. ed.) Springer, New York, NY. 2011
  • Asai T, Oku N: "Angiogenic vessel-targeting DDS by liposomalized oligapeptides." pp.335-347.
    “Liposomes Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers” (Weissig V. ed.) Methods in Molecular Biology 605, Humana Press, Totowa, NJ 2010
  • Oku N, Ishii T: "Antiangiogenic Photodynamic Therapy with Targeted Liposomes." pp. 313-330.
    “Liposomes, Part G” (Düzgüneș N. ed.) Methods in Enzymology 465, Elsevier Academic Press, San Diego CA. 2009
  • Shimizu K, Akizawa T, Asai T, Oku N: "Anti-angiogenic effect of green tea catechin through inhibition of membrane-type I matrix metalloproteinase, MTI-MMP." pp. 41-50.
    “Beneficial Health Effects of Green Tea” (Isemura M. ed.) Research Signpost, Kerala, India. 2008
  • Yonezawa S, Asai T, Oku N: "Dorsal air sac model." pp. 229-238.
    “Angiogenesis Assays” (Staton CA, Lewis C, Bicknell R. eds.) John Wiley & Sons, Ltd. West Sussex, England 2006
  • Oku N; Asai T: "Imaging cell trafficking." pp.349-364.
    “Molecular Imaging of the Lungs” (Schuster DP, Blackwell TS. eds.) Taylor and Francis Group, Boca Raton, FL 2005
  • Oku N; Namba Y: "Glucuronate-modified, long-circulating liposomes for the delivery of anticancer agents." 145-162.
    “Liposomes, Part E” (Düzgüneș N. ed.) Methods in Enzymology 391, Elsevier Academic Press, San Diego, CA 2005
  • Taki T; Oku N ”Inhibition of tumor metastasis by liposomes containing glyco-replica peptides.” pp.219-231
    “Liposome Methods and Protocols” (Basu SC, Basu M. eds.) Method in Molecular Biology 199, Humana Press, Totowa, NJ 2002
  • Oku N: Chapter 18 "Tumor imaging with long circulating liposomes." pp. 257-266.
    "Long Circulating Liposomes: Old Drugs, New Therapeutics." (Woodle MC, Storm G. eds.) Springer-Verlag, Berlin 1998
  • Liao J, Oku N, Suda Y, Ottenbrite RM: Chapter 8 "Hydrophobic modification of poly (MA-CDA) to enhance biological activity." pp. 247-265.
    "Functional Monomers and Polymeric Materials" (Takemoto K, Ottenbrite RM, Kamachi M. eds.) Marcel Dekker Inc. New York, NY 1997
  • Oku N, Ottenbrite RM, Suda Y: Chapter 14, "Hydrophobization of polyanionic polymers to achieve higher biological activity." pp. 179-188.
    "Handbook of Engineering Polymeric Materials" (Cheremisinoff, NP. ed.) Marcel Dekker, Inc. New York, NY 1997
  • リポソームの作成と実験法 (科学と生物実験ライン27)
    奥 直人 広川書店 1994
  • Suda Y; Kusumoto, S; Oku N: "Enhancement of cell membrane affinity and biological activity of polyanionic polymers." pp.149-162
    "Polymeric Drugs and Drug Administration" (Ottenbrite RM. ed.) ACS Symposium Series 545, American Chemical Society. 1994
  • Oku N, Koike C, Sugawra M, Tsukada H, Irimura T, Okada S: "Imaging of metastatic tumor cell trafficking." pp. 79-81
    Oku N, Koike C, Sugawra M, Tsukada H, Irimura T, Okada S: "Imaging of metastatic tumor cell trafficking." pp. 79-81 "Clinical PET in Oncology" (Matsuzawa T. ed.) World Scientific Publishing Co. 1994
  • Tsujimoto M; Oku N: Chap. 7. "Regulations of TNF receptors." pp. 149-160.
    "Tumor Necrosis Factors: Structure, Function, and Mechanisms of Action" (Aggarwal BB, Vilcek J. eds.) Immunology Series 56, Marcel Dekker, Inc. NY. 1991
  • Oku N: Chap. 3. "Liposomes." pp. 24-33.
    ”Polymeric Drugs and Drug Delivery Systems" (Dunn RL, Ottenbrite RM. eds.) ACS Symposium Series 469, American Chemical Society ACS Symposium Series 1991
  • MacDonald RC; Oku N; MacDonald RI "Liposome formation re-visited." pp. 63-72
    "Liposome Letters" (Bangham AD. ed.) Academic Press, Inc. London 1983


Industrial Property Rights

Awards & Honors

  • 2019/09 Liposome Research Days The Alec D. Bangham, MD, FRS Achievement Award for Lifetime Contributions in Liposome Researvch
    受賞者: Naoto Oku
  • 2016 日本薬学会賞 受賞
    受賞者: 奥 直人
  • 2015 日本薬剤学会タケル・アヤ・ヒグチ記念賞 受賞
    受賞者: 奥 直人
  • 2012 日本DDS学会永井賞 受賞
    受賞者: 奥 直人
  • 1995 日本薬学会奨励賞 受賞
    受賞者: 奥直人

Research Grants & Projects

  • ポジトロンCTを用いる癌転移機構の研究
  • リポソームの薬物送達システムへの応用
  • Study on Metastasis using Positron Emission Tomography
  • Application of Liposomes for Drug Delivery System