Oku Naoto

Researcher Information

Affiliation

Faculty of Pharma-Science Specially Appointed Professor

Degree

• Ph.D（1980/11 University of Tokyo）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901090925434555

J-Global ID

• 200901090925434555

Profile

• 東京都世田谷区生まれ，都立戸山高校卒，東京大学薬学部卒・大学院薬学系研究科博士課程修了(薬学博士)．米国ノースウエスタン大学留学後，摂南大学薬学部講師/助教授，静岡県立大学薬学部助教授/教授(薬学部長，副学長，理事，大学院薬食生命科学総合学府長歴任)．元日本薬学会会頭．専門は薬物送達学．

Research Interests

• Drug Delivery System   Life Science   drug delivery Systems   Radiobiochemistry   Medical biochemistry   

Research Areas

• Life sciences / Clinical pharmacy
• Life sciences / Pharmaceuticals - health and biochemistry

Academic & Professional Experience

• 2018/04 - Today  Teikyo UniversityFaculty of Pharma-Science
• 1998 - 2018  University of ShizuokaSchool of Pharmaceutical Sciences
• 1991 - 1998  University of ShizuokaSchool of Pharmaceutical Sciences
• 1991 - 1998  Associate Professor University of Shizuoka
• 1998  - Professor University of Shizuoka
• 1987 - 1991  Setsunan UniversityFaculty of Pharmaceutical Sciences
• 1987 - 1991  Associate Professor Setsunan University
• 1983 - 1987  Setsunan UniversityFaculty of Pharmaceutical Sciences
• 1983 - 1987  Assistant Professor Setsunan University
• 1982 - 1983  Research associate, Northwestern University
• 1981 - 1982  Postdoctoral fellow, Northwestern University
• 1980 - 1981  Research assistant, university of tokyo

Education

• 1975 - 1980  The University of Tokyo  Graduate School of Pharmaceutical Sciences
• 1971 - 1975  The University of Tokyo  Faculty of Pharmaceutical Sciences

Association Memberships

• 日本薬学教育学会   Control Release Society   国際リポソーム学会   日本DDS学会   日本薬学会   

Research Activity Information

Published Papers

• Cooling-induced, localized release of cytotoxic peptides from engineered polymer nanoparticles in living mice for cancer therapy.

  Hiroyuki Koide; Kazuhiro Saito; Keiichi Yoshimatsu; Beverly Chou; Yu Hoshino; Sei Yonezawa; Naoto Oku; Tomohiro Asai; Kenneth J Shea

  Journal of controlled release : official journal of the Controlled Release Society 355 745 - 759 2023/03
• Treatment of PTEN-Null Breast Cancer by a Synthetic Lethal Approach Involving PARP1 Gene Silencing.

  Tomohiro Asai; Masafumi Yokota; Hideki Isomura; Hiroyuki Koide; Naoyuki Sakurai; Ayaka Okamoto; Hidenori Ando; Takehisa Dewa; Naoto Oku

  Journal of pharmaceutical sciences 2023/02
• Easy preparation of a liposome-mediated protein delivery system by freeze-thawing a liposome-protein complex.

  Hiroyuki Koide; Hiroki Ochiai; Hikaru Suzuki; Shinya Hirata; Midori Watanabe; Sei Yonezawa; Takehisa Dewa; Naoto Oku; Tomohiro Asai

  Journal of materials chemistry. B 10 (35) 6768 - 6776 2022/09
• 社会のアンメットニーズに応えるDDS 凍結融解技術を駆使した核酸・タンパク質送達方法の開発

  小出 裕之; 米澤 正; 出羽 毅久; 奥 直人; 浅井 知浩

  日本DDS学会学術集会プログラム予稿集 日本DDS学会 38回 74 - 74 2022/06
• Application and Utility of Liposomal Neuroprotective Agents and Biomimetic Nanoparticles for the Treatment of Ischemic Stroke.

  Tatsuya Fukuta; Naoto Oku; Kentaro Kogure

  Pharmaceutics 14 (2) 2022/02
• Synthetic hydrogel nanoparticles for sepsis therapy.

  Hiroyuki Koide; Anna Okishima; Yu Hoshino; Yuri Kamon; Keiichi Yoshimatsu; Kazuhiro Saito; Ikumi Yamauchi; Saki Ariizumi; Yuqi Zhou; Ting-Hui Xiao; Keisuke Goda; Naoto Oku; Tomohiro Asai; Kenneth J Shea

  Nature communications 12 (1) 5552 - 5552 2021/09
• Design of abiotic polymer ligand-decorated lipid nanoparticles for effective neutralization of target toxins in the blood.

  Hiroyuki Koide; Ikumi Yamauchi; Yu Hoshino; Go Yasuno; Takumi Okamoto; Sotaro Akashi; Kazuhiro Saito; Naoto Oku; Tomohiro Asai

  Biomaterials science 9 (16) 5588 - 5598 2021/08
• Influence of Purification Process on the Function of Synthetic Polymer Nanoparticles

  Go Yasuno; Hiroyuki Koide; Naoto Oku; Tomohiro Asai

  Chemical and Pharmaceutical Bulletin Pharmaceutical Society of Japan 69 (8) 773 - 780 0009-2363 2021/08
• Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine.

  Hiroyuki Koide; Naoki Hayashi; Go Yasuno; Anna Okishima; Yu Hoshino; Hiromichi Egami; Yoshitaka Hamashima; Naoto Oku; Tomohiro Asai

  Biochemical and biophysical research communications 561 1 - 6 2021/07
• Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine

  Hiroyuki Koide; Naoki Hayashi; Go Yasuno; Anna Okishima; Yu Hoshino; Hiromichi Egami; Yoshitaka Hamashima; Naoto Oku; Tomohiro Asai

  Biochemical and Biophysical Research Communications Elsevier BV 561 1 - 6 0006-291X 2021/07
• Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles.

  Hiroyuki Koide; Hikaru Suzuki; Hiroki Ochiai; Hiromichi Egami; Yoshitaka Hamashima; Naoto Oku; Tomohiro Asai

  Biochemical and biophysical research communications 555 32 - 39 2021/05
• New strategy for MS treatment with autoantigen-modified liposomes and their therapeutic effect.

  Kosuke Shimizu; Kazuki Agata; Shohei Takasugi; Shungo Goto; Yudai Narita; Tomohiro Asai; Yasuhiro Magata; Naoto Oku

  Journal of controlled release : official journal of the Controlled Release Society 335 389 - 397 2021/05
• Metastasis of Breast Cancer Promoted by Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice

  Minoru Numata; Akane Hirano; Yukika Yamamoto; Michiko Yasuda; Nobuhiko Miura; Kazutoshi Sayama; Masa-Aki Shibata; Tomohiro Asai; Naoto Oku; Noriyuki Miyoshi; Kayoko Shimoi

  Journal of Circadian Rhythms Ubiquity Press, Ltd. 19 (1) 2 - 2 2021/02
• Influence of Purification Process on the Function of Synthetic Polymer Nanoparticles.

  Go Yasuno; Hiroyuki Koide; Naoto Oku; Tomohiro Asai

  Chemical & pharmaceutical bulletin 69 (8) 773 - 780 2021
• Design of abiotic polymer ligand-decorated lipid nanoparticles for effective neutralization of target toxins in the blood

  Hiroyuki Koide; Ikumi Yamauchi; Yu Hoshino; Go Yasuno; Takumi Okamoto; Sotaro Akashi; Kazuhiro Saito; Naoto Oku; Tomohiro Asai

  Biomaterials Science Royal Society of Chemistry (RSC) 2047-4830 2021
• Engineering of Lipid Nanoparticles by the Multifunctionalization of the Surface with Amino Acid Derivatives for the Neutralization of a Target Toxic Peptide

  Hiroyuki Koide; Satoshi Hirano; Takafumi Ide; Kazuhiro Saito; Hikaru Suzuki; Go Yasuno; Yoshitaka Hamashima; Sei Yonezawa; Naoto Oku; Tomohiro Asai

  ADVANCED FUNCTIONAL MATERIALS WILEY-V C H VERLAG GMBH 31 (3) 1616-301X 2021/01
• 多発性硬化症治療に向けた自己抗原修飾リポソーム製剤の開発

  清水 広介; 高杉 昇平; 阿形 寿規; 成田 雄大; 浅井 知浩; 奥 直人; 間賀田 泰寛

  神経免疫学 日本神経免疫学会 25 (1) 101 - 101 0918-936X 2020/10
• Release rate is a key variable affecting the therapeutic effectiveness of liposomal fasudil for the treatment of cerebral ischemia/reperfusion injury

  Yosuke Yanagida; Mio Namba; Tatsuya Fukuta; Hirokazu Yamamoto; Mitsuaki Yanagida; Miki Honda; Naoto Oku; Tomohiro Asai

  Biochemical and Biophysical Research Communications Elsevier BV 531 (4) 622 - 627 0006-291X 2020/10
• DDSとの融合による分子イメージングの新展開 標的化DDSの利用による動脈硬化巣の非侵襲的光イメージング

  清水 広介; 成田 雄大; 浅井 知浩; 奥 直人; 小川 美香子; 間賀田 泰寛

  日本DDS学会学術集会プログラム予稿集 日本DDS学会 36回 95 - 95 2020/08
• Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery.

  Yusuke Hirai; Ryoko Saeki; Furan Song; Hiroyuki Koide; Naofumi Fukata; Koji Tomita; Noriyuki Maeda; Naoto Oku; Tomohiro Asai

  International journal of pharmaceutics 585 119479 - 119479 2020/07
• 自己抗原認識免疫細胞を標的とする多発性硬化症治療薬の開発

  清水 広介; 高杉 昇平; 阿形 寿規; 成田 雄大; 浅井 知浩; 奥 直人; 間賀田 泰寛

  日本薬剤学会年会講演要旨集 (公社)日本薬剤学会 35年会 171 - 171 2020/05
• Development of tissue factor-targeted liposomes for effective drug delivery to stroma-rich tumors.

  Kosuke Shimizu; Yoshihito Takeuchi; Kazuma Otsuka; Tomoya Mori; Yudai Narita; Shohei Takasugi; Yasuhiro Magata; Yasuhiro Matsumura; Naoto Oku

  Journal of controlled release : official journal of the Controlled Release Society 323 519 - 529 2020/04 [Refereed]
  
• Challenge for oral delivery of middle-molecular drugs: Use of osmolarity-sensitive liposome as a drug carrier in the GI tract

  Keiko Minam; Asuka Takazawa; Yuki Taniguchi; Haruki Higashino; Makoto Kataoka; Tomohiro Asai; Naoto Oku; Shinji Yamashita

  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY ELSEVIER 56 1773-2247 2020/04
• Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions.

  Kikuchi T, Fukuta T, Agato Y, Yanagida Y, Ishii T, Koide H, Shimizu K, Oku N, Asai T.

  J Pharm Sci. 108 (12) 3823 - 3830 2019/12 [Refereed]
  
• Engineering the Binding Kinetics of Synthetic Polymer Nanoparticles for siRNA Delivery.

  Hiroyuki Koide; Tatsuya Fukuta; Anna Okishim; Saki Ariizumi; Chiaki Kiyokawa; Hiroki Tsuchida; Masahiko Nakamoto; Keiichi Yoshimatsu; Hidenori Ando; Takehisa Dewa; Tomohiro Asai; Naoto Oku; Yu Hoshino; Kenneth J Shea

  Biomacromolecules 20 (10) 3648 - 3657 2019/10 [Refereed]
  
• Key determinants of siRNA delivery mediated by unique pH-responsive lipid-based liposomes.

  Sako M, Song F, Okamoto A, Koide H, Dewa T, Oku N, Asai T.

  Int J Pharm. 569 118606  2019/10 [Refereed]
  
• Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus.

  Zang L, Shimada Y, Nakayama H, Chen W, Okamoto A, Koide H, Oku N, Dewa T, Shiota M, Nishimura N.

  Front Genet. 10 693  2019/07 [Refereed]
  
• リポソーム化Fasudilの薬物放出性が脳虚血再灌流障害の治療効果に及ぼす影響

  柳田 洋翼; 福田 達也; 南場 美緒; 本田 美樹; 柳田 光昭; 奥 直人; 浅井 知浩

  日本DDS学会学術集会プログラム予稿集 日本DDS学会 35回 134 - 134 2019/06
• Design of a Novel PEGylated Liposomal Vector for Systemic Delivery of siRNA to Solid Tumors.

  Song F, Sakurai N, Okamoto A, Koide H, Oku N, Dewa T, Asai T.

  Biol Pharm Bull. 42 (6) 996 - 1003 2019/06 [Refereed]
  
• Determination of Dipicolinic Acid in "Natto" by High-Performance Liquid Chromatography Coupled With Postcolumn Photoirradiation With Zinc Acetate.

  Mawatari KI, Atsumi M, Nakamura F, Yasuda M, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K, Oku N.

  Int J Tryptophan Res. 12 1178646919852120 - 1178646919852120 2019/06 [Refereed]
  
• Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques.

  Narita Y, Shimizu K, Ikemoto K, Uchino R, Kosugi M, Maess MB, Magata Y, Oku N, Ogawa M.

  J Control Release. 302 105 - 115 2019/05 [Refereed]
  
• Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule.

  Okishima A, Koide H, Hoshino Y, Egami H, Hamashima Y, Oku N, Asai T.

  Biomacromolecules. 20 (4) 1644 - 1654 2019/04 [Refereed]
  
• Simultaneous Determination of Kynurenine and Kynurenic Acid by High-Performance Liquid Chromatography Photoirradiation System Using a Mobile Phase Containing 18-crown-6.

  Atsumi M, Mawatari KI, Morooka A, Yasuda M, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K, Oku N.

  Int J Tryptophan Res. 12 1178646919834551 - 1178646919834551 2019/03 [Refereed]
  
• Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke.

  Fukuta T, Ishii T, Asai T, Oku N.

  Biol Pharm Bull. 42 (3) 319 - 326 2019/03 [Refereed]
  
• Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle.

  Koide H, Yoshimatsu K, Hoshino Y, Ariizumi S, Okishima A, Ide T, Egami H, Hamashima Y, Nishimura Y, Kanazawa H, Miura Y, Asai T, Oku N, Shea KJ.

  J Control Release. 295 13 - 20 2019/02 [Refereed]
  
• Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA.

  Okamoto A, Koide H, Morita N, Hirai Y, Kawato Y, Egami H, Hamashima Y, Asai T, Dewa T, Oku N.

  J Control Release. 295 87 - 92 2019/02 [Refereed]
  
• Systemic Administration of siRNA with Anti-HB-EGF Antibody-Modified Lipid Nanoparticles for the Treatment of Triple-Negative Breast Cancer

  Ayaka Okamoto; Tomohiro Asai; Yusuke Hirai; Kosuke Shimizu; Hiroyuki Koide; Tetsuo Minamino; Naoto Oku

  Molecular Pharmaceutics American Chemical Society 15 (4) 1495 - 1504 1543-8392 2018/04 [Refereed]
  
• Prediction of the Oral Pharmacokinetics and Food Effects of Gabapentin Enacarbil Extended-Release Tablets Using Biorelevant Dissolution Tests.

  Yamaguchi Ikeuchi S, Kambayashi A, Kojima H, Oku N, Asai T.

  Biol Pharm Bull. 41 (11) 1708 - 1715 2018/01 [Refereed]
  
• Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis

  Tatsuya Fukuta; Yosuke Yanagida; Tomohiro Asai; Naoto Oku

  Biochemical and Biophysical Research Communications Elsevier B.V. 495 (1) 873 - 877 1090-2104 2018/01 [Refereed]
  
• Nobiletin reduces intracellular and extracellular β-amyloid in iPS cell-derived Alzheimer's disease model neurons

  Junko Kimura; Kosuke Shimizu; Koji Kajima; Akihito Yokosuka; Yoshihiro Mimaki; Naoto Oku; Yasushi Ohizumi

  Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 41 (4) 451 - 457 1347-5215 2018 [Refereed]
  
• Involvement of tumor lymphatic system in translocation of intratumorally injected liposomes

  Kosuke Shimizu; Satomi Yamaguchi Ikeuchi; Ai Okajima; Genki Nakamura; Eiichi Muraoka; Naoto Oku

  Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 41 (4) 652 - 656 1347-5215 2018 [Refereed]
  
• Anticancer Efficacy of the Combination of Berberine and PEGylated Liposomal Doxorubicin in Meth A Sarcoma-Bearing Mice.

  Yahuafai J; Asai T; Oku N; Siripong P

  Biological & pharmaceutical bulletin 41 (7) 1103 - 1106 0918-6158 2018 [Refereed]
  
• Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins

  Hiroyuki Koide; Hiroki Tsuchida; Masahiko Nakamoto; Anna Okishima; Saki Ariizumi; Chiaki Kiyokawa; Tomohiro Asai; Yu Hoshino; Naoto Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 268 335 - 342 0168-3659 2017/12 [Refereed]
  
• A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF(165))

  Hiroyuki Koide; Keiichi Yoshimatsu; Yu Hoshino; Shih-Hui Lee; Ai Okajima; Saki Ariizumi; Yudai Narita; Yusuke Yonamine; Adam C. Weisman; Yuri Nishimura; Naoto Oku; Yoshiko Miura; Kenneth J. Shea

  NATURE CHEMISTRY NATURE PUBLISHING GROUP 9 (7) 715 - 722 1755-4330 2017/07 [Refereed]
  
• Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke

  Tatsuya Fukuta; Tomohiro Asai; Yosuke Yanagida; Mio Namba; Hiroyuki Koide; Kosuke Shimizu; Naoto Oku

  FASEB JOURNAL FEDERATION AMER SOC EXP BIOL 31 (5) 1879 - 1890 0892-6638 2017/05 [Refereed]
  
• Process optimization by use of design of experiments: Application for liposomalization of FK506

  Hiroyasu Toyota; Tomohiro Asai; Naoto Oku

  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES ELSEVIER SCIENCE BV 102 196 - 202 0928-0987 2017/05 [Refereed]
  
• Targeted delivery of anticancer drugs to tumor vessels by use of liposomes modified with a peptide identified by phage biopanning with human endothelial progenitor cells

  Tatsuya Fukuta; Tomohiro Asai; Yuri Kiyokawa; Takashi Nakada; Koji Bessyo-Hirashima; Natsuki Fukaya; Kenji Hyodo; Kazuma Takase; Hiroshi Kikuchi; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 524 (1-2) 364 - 372 0378-5173 2017/05 [Refereed]
  
• Amelioration of Citrobacter rodentium proliferation in early stage of infection in mice by pretreatment with Lactobacillus brevis KB290 and verification using in vivo bioluminescence imaging

  Naoko Waki; Yuki Kuwabara; Yuko Yoshikawa; Hiroyuki Suganuma; Hiroyuki Koide; Naoto Oku; Norio Ohashi

  FEMS MICROBIOLOGY LETTERS OXFORD UNIV PRESS 364 (6) 0378-1097 2017/03 [Refereed]
  
• Innovations in Liposomal DDS Technology and Its Application for the Treatment of Various Diseases

  Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 40 (2) 119 - 127 0918-6158 2017/02 [Refereed]
  
• Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect

  Kosuke Shimizu; Haruna Miyauchi; Takeo Urakami; Kanae Yamamura-Ichikawa; Sei Yonezawa; Tomohiro Asai; Naoto Oku

  JOURNAL OF DRUG TARGETING TAYLOR & FRANCIS LTD 24 (9) 890 - 895 1061-186X 2016/11 [Refereed]
  
• Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats

  Keiji Okuda; Hai Ying Fu; Takashi Matsuzaki; Ryo Araki; Shota Tsuchida; Punniyakoti V. Thanikachalam; Tatsuya Fukuta; Tomohiro Asai; Masaki Yamato; Shoji Sanada; Hiroshi Asanuma; Yoshihiro Asano; Masanori Asakura; Haruo Hanawa; Hiroyuki Hao; Naoto Oku; Seiji Takashima; Masafumi Kitakaze; Yasushi Sakata; Tetsuo Minamino

  PLOS ONE PUBLIC LIBRARY SCIENCE 11 (8) e0160944  1932-6203 2016/08 [Refereed]
  
• Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity

  Tatsuya Fukuta; Tomohiro Asai; Takayuki Ishii; Hiroyuki Koide; Chiaki Kiyokawa; Masahiro Hashimoto; Takashi Kikuchi; Kosuke Shimizu; Norihiro Harada; Hideo Tsukada; Naoto Oku

  SCIENTIFIC REPORTS NATURE PUBLISHING GROUP 6 30127  2045-2322 2016/07 [Refereed]
  
• Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil

  Tatsuya Fukuta; Tomohiro Asai; Akihiko Sato; Mio Namba; Yosuke Yanagida; Takashi Kikuchi; Hiroyuki Koide; Kosuke Shimizu; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 506 (1-2) 129 - 137 0378-5173 2016/06 [Refereed]
  
• Ameliorating Effects of Sphingomyelin-Based Liposomes on Sarcopenia in Senescence-Accelerated Mice

  Yuuki Ishida; Yuri Kiyokawa; Tomohiro Asai; Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 39 (5) 786 - 793 0918-6158 2016/05 [Refereed]
  
• Development of nucleic acid delivery system using lipid nanoparticles

  Ayaka Okamoto; Tomohiro Asai; Naoto Oku

  Drug Delivery System Japan Society of Drug Delivery System 31 (1) 54 - 61 1881-2732 2016/04 [Refereed]
  
• Construction of a healthy longevity society through drug delivery systems: Nucleic acid medicines and DDS

  Naoto Oku

  Drug Delivery System Japan Society of Drug Delivery System 31 (1) 7  1881-2732 2016/04 [Refereed]
  
• SYNTHESIS OF CHEMICAL-BIOLOGY TOOLS ENABLING IN VIVO IMAGING AND ANALYSIS OF EPIGALLOCATECHIN GALLATE

  Tomohiro Asakawa; Atsushi Yoshida; Yasuo Hirooka; Takashi Suzuki; Kunihiko Itoh; Kosuke Shimizu; Naoto Oku; Takumi Furuta; Toshiyuki Wakimoto; Makoto Inai; Toshiyuki Kan

  HETEROCYCLES PERGAMON-ELSEVIER SCIENCE LTD 93 (1) 218 - 242 0385-5414 2016/04 [Refereed]
  
• One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing

  Hiroyuki Koide; Ayaka Okamoto; Hiroki Tsuchida; Hidenori Ando; Saki Ariizumi; Chiaki Kiyokawa; Masahiro Hashimoto; Tomohiro Asai; Takehisa Dewa; Naoto Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 228 1 - 8 0168-3659 2016/04 [Refereed]
  
• Bauhinia purprea agglutinin-modified liposomes for human prostate cancer treatment

  Keisuke Ikemoto; Kosuke Shimizu; Kento Ohashi; Yoshihito Takeuchi; Motohiro Shimizu; Naoto Oku

  CANCER SCIENCE WILEY-BLACKWELL 107 (1) 53 - 59 1347-9032 2016/01 [Refereed]
  
• Enhanced Efficacy of Doxorubicin by microRNA-499-Mediated Improvement of Tumor Blood Flow

  Ayaka Okamoto; Tomohiro Asai; Sho Ryu; Hidenori Ando; Noriyuki Maeda; Takehisa Dewa; Naoto Oku

  JOURNAL OF CLINICAL MEDICINE MDPI AG 5 (1) 2077-0383 2016/01 [Refereed]
  
• Development of a liposomal drug delivery system for the treatment of ischemic stroke

  Tatsuya Fukuta; Tomohiro Asai; Naoto Oku

  Drug Delivery System Japan Society of Drug Delivery System 30 (4) 309 - 316 1881-2732 2015/12 [Refereed]
  
• Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions

  Tatsuya Fukuta; Takayuki Ishii; Tomohiro Asai; Akihiko Sato; Takashi Kikuchi; Kosuke Shimizu; Tetsuo Minamino; Naoto Oku

  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS ELSEVIER SCIENCE BV 97 (Pt A) 1 - 7 0939-6411 2015/11 [Refereed]
  
• Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model

  Ryo Kojima; Takatsune Yoshida; Hiroaki Tasaki; Hiroyuki Umejima; Masashi Maeda; Yasuyuki Higashi; Shunsuke Watanabe; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 492 (1-2) 20 - 27 0378-5173 2015/08 [Refereed]
  
• Upregulatory effects of nobiletin, a citrus flavonoid with anti-dementia activity, on the gene expression of mAChR, ChAT, and CBP

  Junko Kimura; Kosuke Shimizu; Jiro Takito; Kiyomitsu Nemoto; Masakuni Degawa; Akihito Yokosuka; Yoshihiro Mimaki; Naoto Oku; Yasushi Ohizumi

  Planta Medica Letters 2 (1) e12 - e14 2015/01 [Refereed]
  
• Formulation Design and Evaluation of Liposomal Sepantronium Bromide (YM155), a Small-Molecule Survivin Suppressant, Based on Pharmacokinetic Modeling and Simulation

  Kohsuke Shakushiro; Hiroki Kawano; Mari Nakata; Aya Kita; Atsushi Maeda; Shunsuke Watanabe; Kazuhiro Sako; Naoto Oku

  PHARMACEUTICAL RESEARCH SPRINGER/PLENUM PUBLISHERS 32 (1) 238 - 247 0724-8741 2015/01 [Refereed]
  
• Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin

  Hiroyuki Koide; Tomohiro Asai; Hiroki Kato; Norihito Yonenaga; Masafumi Yokota; Hidenori Ando; Takehisa Dewa; Mamoru Nango; Noriyuki Maeda; Naoto Oku

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE ELSEVIER SCIENCE BV 11 (1) 185 - 194 1549-9634 2015/01 [Refereed]
  
• Suppression in mice of immunosurveillance against PEGylated liposomes by encapsulated doxorubicin

  Jantana Yahuafai; Tomohiro Asai; Genki Nakamura; Tatsuya Fukuta; Pongpun Siripong; Kenji Hyodo; Hiroshi Ishihara; Hiroshi Kikuchi; Naoto Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 192 167 - 173 0168-3659 2014/10 [Refereed]
  
• Upregulation of N-Methyl-D-aspartate Receptor Subunits and c-Fos Expressing Genes in PC12D Cells by Nobiletin

  Junko Kimura; Kiyomitsu Nemoto; Masakuni Degawa; Akihito Yokosuka; Yoshihiro Mimaki; Kosuke Shimizu; Naoto Oku; Yasushi Ohizumi

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 37 (9) 1555 - 1558 0918-6158 2014/09 [Refereed]
  
• Antitumor efficacy and biodistribution of liposomal sepantronium bromide (YM155), a novel small-molecule survivin suppressant

  Hiroki Kawano; Kohsuke Shakushiro; Mari Nakata; Aya Kita; Atsushi Maeda; Shunsuke Watanabe; Kazuhiro Sako; Naoto Oku

  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS ELSEVIER SCIENCE BV 88 (1) 283 - 289 0939-6411 2014/09 [Refereed]
  
• In vivo molecular imaging techniques for non-invasive atherosclerotic plaque detection

  Mikako Ogawa; Kosuke Shimizu; Huijun Zhu; Yasuhiro Magata; Naoto Oku

  Transactions of Japanese Society for Medical and Biological Engineering Japan Soc. of Med. Electronics and Biol. Engineering 52 60 - SY-61 1347-443X 2014/08 [Refereed]
  
• Real-Time Trafficking of PEGylated Liposomes in the Rodent Focal Brain Ischemia Analyzed by Positron Emission Tomography

  Tatsuya Fukuta; Takayuki Ishii; Tomohiro Asai; Genki Nakamura; Yoshihito Takeuchi; Akihiko Sato; Yurika Agato; Kosuke Shimizu; Shuji Akai; Dai Fukumoto; Norihiro Harada; Hideo Tsukada; Akira T. Kawaguchi; Naoto Oku

  ARTIFICIAL ORGANS WILEY-BLACKWELL 38 (8) 662 - 666 0160-564X 2014/08 [Refereed]
  
• Doxorubicin内封PEG修飾リポソームにおける薬剤放出速度が抗腫瘍効果に及ぼす影響

  濱田 直樹; 福田 達也; 清河 友理; 浅井 知浩; 大河原 賢一; 檜垣 和孝; 兵動 健治; 石原 比呂之; 菊池 寛; 奥 直人

  日本DDS学会学術集会プログラム予稿集 日本DDS学会 30回 152 - 152 2014/07
• ドキソルビシン内封リポソーム製剤の抗腫瘍効果決定因子の解析

  河合 理江; 金只 駿祐; 浅井 知浩; 奥 直人; 兵頭 健治; 石原 比呂之; 菊池 寛; 大河原 賢一; 檜垣 和孝

  日本DDS学会学術集会プログラム予稿集 日本DDS学会 30回 153 - 153 2014/07
• Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF

  Ayaka Okamoto; Tomohiro Asai; Hiroki Kato; Hidenori Ando; Tetsuo Minamino; Eisuke Mekada; Naoto Oku

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 449 (4) 460 - 465 0006-291X 2014/07 [Refereed]
  
• EPC結合性ペプチドを用いた標的化DDSによるがん治療

  清河 友理; 中田 貴志; 平島 幸治; 濱田 直樹; 清水 広介; 浅井 知浩; 兵頭 健治; 石原 比呂之; 菊池 寛; 奥 直人

  日本薬剤学会年会講演要旨集 (公社)日本薬剤学会 29年会 120 - 120 2014/05
• Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499

  Hidenori Ando; Tomohiro Asai; Hiroyuki Koide; Ayaka Okamoto; Noriyuki Maeda; Koji Tomita; Takehisa Dewa; Tetsuo Minamino; Naoto Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 181 32 - 39 0168-3659 2014/05 [Refereed]
  
• Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats

  Nodoka Yasuda; Takayuki Ishii; Dai Oyama; Tatsuya Fukuta; Yurika Agato; Akihiko Sato; Kosuke Shimizu; Tomohiro Asai; Tomohiro Asakawa; Toshiyuki Kan; Shizuo Yamada; Yasushi Ohizumi; Naoto Oku

  BRAIN RESEARCH ELSEVIER 1559 46 - 54 0006-8993 2014/04 [Refereed]
  
• Doxorubicin内封PEG修飾リポソームの抗腫瘍効果における薬剤放出速度の影響

  濱田 直樹; 福田 達也; 清河 友理; 浅井 知浩; 大河原 賢一; 檜垣 和孝; 兵頭 健治; 石原 比呂之; 菊池 寛; 奥 直人

  日本薬学会年会要旨集 (公社)日本薬学会 134年会 (4) 78 - 78 0918-9823 2014/03
• Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery

  Tomohiro Asai; Takuma Tsuzuku; Shoya Takahashi; Ayaka Okamoto; Takehisa Dewa; Mamoru Nango; Kenji Hyodo; Hiroshi Ishihara; Hiroshi Kikuchi; Naoto Oku

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 444 (4) 599 - 604 0006-291X 2014/02 [Refereed]
  
• Systemic Delivery of Small RNA Using Lipid Nanoparticles

  Tomohiro Asai; Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 37 (2) 201 - 205 0918-6158 2014/02 [Refereed]
  
• Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin

  Kosuke Shimizu; Tomohiro Asakawa; Norihiro Harada; Dai Fukumoto; Hideo Tsukada; Tomohiro Asai; Shizuo Yamada; Toshiyuki Kan; Naoto Oku

  PLOS ONE PUBLIC LIBRARY SCIENCE 9 (2) e85520  1932-6203 2014/02 [Refereed]
  
• Visualization of Sialidase Activity in Mammalian Tissues and Cancer Detection with a Novel Fluorescent Sialidase Substrate

  Akira Minami; Tadamune Otsubo; Daisuke Ieno; Kiyoshi Ikeda; Hiroaki Kanazawa; Kosuke Shimizu; Ko Ohata; Tsunehiro Yokochi; Yuuki Horii; Hokuto Fukumoto; Risa Taguchi; Tadanobu Takahashi; Naoto Oku; Takashi Suzuki

  PLOS ONE PUBLIC LIBRARY SCIENCE 9 (1) e81941  1932-6203 2014/01 [Refereed]
  
• Polycation liposomes as a vector for potential intracellular delivery of microRNA

  Hidenori Ando; Ayaka Okamoto; Masafumi Yokota; Tomohiro Asai; Takehisa Dewa; Naoto Oku

  JOURNAL OF GENE MEDICINE WILEY-BLACKWELL 15 (10) 375 - 383 1099-498X 2013/10 [Refereed]
  
• Enhanced Susceptibility to Spontaneous Seizures of Noda Epileptic Rats by Loss of Synaptic Zn2+

  Atsushi Takeda; Masashi Iida; Masaki Ando; Masatoshi Nakamura; Haruna Tamano; Naoto Oku

  PLOS ONE PUBLIC LIBRARY SCIENCE 8 (8) e71372  1932-6203 2013/08 [Refereed]
  
• Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in Rats: Positron Emission Tomography Imaging after Oral Administration of Nonabsorbable Marker, [F-18]Deoxyfluoropoly(ethylene glycol)

  Tadayuki Takashima; Tomotaka Shingaki; Yumiko Katayama; Emi Hayashinaka; Yasuhiro Wada; Makoto Kataoka; Daiki Ozaki; Hisashi Doi; Masaaki Suzuki; Sho Ishida; Kentaro Hatanaka; Yuichi Sugiyama; Shuji Akai; Naoto Oku; Shinji Yamashita; Yasuyoshi Watanabe

  MOLECULAR PHARMACEUTICS AMER CHEMICAL SOC 10 (6) 2261 - 2269 1543-8384 2013/06 [Refereed]
  
• Enhanced Active Targeting via Cooperative Binding of Ligands on Liposomes to Target Receptors

  Tomoki Sugiyama; Tomohiro Asai; Yuki Murase Nedachi; Yasufumi Katanasaka; Kosuke Shimizu; Noriyuki Maeda; Naoto Oku

  PLOS ONE PUBLIC LIBRARY SCIENCE 8 (6) e67550  1932-6203 2013/06 [Refereed]
  
• Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy

  Kanae Ichikawa; Tomohiro Asai; Kosuke Shimizu; Sei Yonezawa; Takeo Urakami; Haruna Miyauchi; Hiroto Kawashima; Tatsuhiro Ishida; Hiroshi Kiwada; Naoto Oku

  Journal of Controlled Release 167 (3) 284 - 289 0168-3659 2013/05 [Refereed]
  
• Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506

  Takayuki Ishii; Tomohiro Asai; Dai Oyama; Yurika Agato; Nodoka Yasuda; Tatsuya Fukuta; Kosuke Shimizu; Tetsuo Minamino; Naoto Oku

  FASEB Journal 27 (4) 1362 - 1370 1530-6860 2013/04 [Refereed]
  
• Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506

  Takayuki Ishii; Tomohiro Asai; Dai Oyama; Yurika Agato; Nodoka Yasuda; Tatsuya Fukuta; Kosuke Shimizu; Tetsuo Minamino; Naoto Oku

  FASEB JOURNAL FEDERATION AMER SOC EXP BIOL 27 (4) 1362 - 1370 0892-6638 2013/04 [Refereed]
  
• Liposomal Amiodarone augments anti-arrhythmic effects and reduces Hemodynamic adverse effects in an ischemia/ reperfusion rat model

  Hiroyuki Takahama; Hirokazu Shigematsu; Tomohiro Asai; Takashi Matsuzaki; Shoji Sanada; Hai Ying Fu; Keiji Okuda; Masaki Yamato; Hiroshi Asanuma; Yoshihiro Asano; Masanori Asakura; Naoto Oku; Issei Komuro; Masafumi Kitakaze; Tetsuo Minamino

  Cardiovascular Drugs and Therapy 27 (2) 125 - 132 0920-3206 2013/04 [Refereed]
  
• Suppression of immune response by antigen-decorated liposomes encapsulating model agents: A novel strategy for the treatment of allergy.

  Ichikawa, K; Asai, T; Shimizu, K; Yonezawa, S; Urakami, T; Miyauchi, H; Kawashima, H; Ishida, T; Kiwada, H; Oku, N

  J. Control. Release 167 (No.3) 284 - 289 1873-4995 2013/02 [Refereed]
  
• Liposomes and nanotechnology in drug development: Focus on ocular targets

  Miki Honda; Tomohiro Asai; Naoto Oku; Yoshihiko Araki; Minoru Tanaka; Nobuyuki Ebihara

  International Journal of Nanomedicine 8 495 - 504 1176-9114 2013/02 [Refereed]
  
• Biomembrane damage caused by exposure to multi-walled carbon nanotubes

  Kosuke Shimizu; Arina Uchiyama; Mina Yamashita; Akihiko Hirose; Tetsuji Nishimura; Naoto Oku

  JOURNAL OF TOXICOLOGICAL SCIENCES JAPANESE SOC TOXICOLOGICAL SCIENCES 38 (1) 7 - 12 0388-1350 2013/02 [Refereed]
  
• Systemic Delivery of Small Interfering RNA by Use of Targeted Polycation Liposomes for Cancer Therapy

  Eriya Kenjo; Tomohiro Asai; Norihito Yonenaga; Hidenori Ando; Takayuki Ishii; Kentaro Hatanaka; Kosuke Shimizu; Yugo Urita; Takehisa Dewa; Mamoru Nango; Hideo Tsukada; Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 36 (2) 287 - 291 0918-6158 2013/02 [Refereed]
  
• Nanoparticles accumulate in ischemic core and penumbra region even when cerebral perfusion is reduced

  Takayuki Ishii; Tatsuya Fukuta; Yurika Agato; Dai Oyama; Nodoka Yasuda; Kosuke Shimizu; Akira T. Kawaguchi; Tomohiro Asai; Naoto Oku

  Biochemical and Biophysical Research Communications 430 (4) 1201 - 1205 0006-291X 2013/01 [Refereed]
  
• Development of a miR-92a delivery system for anti-angiogenesis-based cancer therapy

  Hidenori Ando; Ayaka Okamoto; Masafumi Yokota; Kosuke Shimizu; Tomohiro Asai; Takehisa Dewa; Naoto Oku

  Journal of Gene Medicine 15 (1) 20 - 27 1099-498X 2013/01 [Refereed]
  
• A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion

  Takayuki Ishii; Tomohiro Asai; Tatsuya Fukuta; Dai Oyama; Nodoka Yasuda; Yurika Agato; Kosuke Shimizu; Tetsuo Minamino; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 439 (1-2) 269 - 274 0378-5173 2012/12 [Refereed]
  
• In Vivo Imaging of Liposomal Small Interfering RNA (siRNA) Trafficking by Positron Emission Tomography

  Hidenori Ando; Norihito Yonenaga; Tomohiro Asai; Kentaro Hatanaka; Hiroyuki Koide; Takuma Tsuzuku; Norihiro Harada; Hideo Tsukada; Naoto Oku

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN PHARMACEUTICAL SOC JAPAN 132 (12) 1373 - 1381 0031-6903 2012/12 [Refereed]
  
• Ability of fibrinogen gamma-derived dodecapeptides with different sequences to bind to rat platelets

  Koji Tokutomi; Toshiaki Tagawa; Maki Korenaga; Masatoshi Chiba; Tomohiro Asai; Naohide Watanabe; Shinji Takeoka; Makoto Handa; Yasuo Ikeda; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 438 (1-2) 296 - 301 0378-5173 2012/11 [Refereed]
  
• Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles

  Hiroyuki Koide; Tomohiro Asai; Hiroki Kato; Hidenori Ando; Kouichi Shiraishi; Masayuki Yokoyama; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 432 (1-2) 75 - 79 0378-5173 2012/08 [Refereed]
  
• Inhibitory Effect of Liposomal Rhinacanthin-N Isolated from Rhinacanthus nasutus on Pulmonary Metastasis in Mice

  Pongpun Siripong; Jantana Yahuafai; Suratsawadee Piyaviriyakul; Kwanjai Kanokmedhakul; Hiroyuki Koide; Takayuki Ishii; Kosuke Shimizu; Somsak Ruchirawat; Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 35 (7) 1197 - 1200 0918-6158 2012/07 [Refereed]
  
• RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment

  Norihito Yonenaga; Eriya Kenjo; Tomohiro Asai; Atsushi Tsuruta; Kosuke Shimizu; Takehisa Dewa; Mamoru Nango; Naoto Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 160 (2) 177 - 181 0168-3659 2012/06 [Refereed]
  
• Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer

  Kaoru Nishikawa; Tomohiro Asai; Hirokazu Shigematsu; Kosuke Shimizu; Hisakazu Kato; Yoshihiro Asano; Seiji Takashima; Eisuke Mekada; Naoto Oku; Tetsuo Minamino

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 160 (2) 274 - 280 0168-3659 2012/06 [Refereed]
  
• Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin

  Takayuki Ishii; Tomohiro Asai; Dai Oyama; Tatsuya Fukuta; Nodoka Yasuda; Kosuke Shimizu; Tetsuo Minamino; Naoto Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 160 (1) 81 - 87 0168-3659 2012/05 [Refereed]
  
• Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice

  Atsushi Takeda; Haruka Iwaki; Kazuki Ide; Haruna Tamano; Naoto Oku

  BRAIN RESEARCH BULLETIN PERGAMON-ELSEVIER SCIENCE LTD 87 (6) 551 - 555 0361-9230 2012/04 [Refereed]
  
• Involvement of N-methyl-D-aspartate receptor subunits in zinc-mediated modification of CA1 long-term potentiation in the developing hippocampus

  Atsushi Takeda; Kosuke Itagaki; Masaki Ando; Naoto Oku

  JOURNAL OF NEUROSCIENCE RESEARCH WILEY 90 (3) 551 - 558 0360-4012 2012/03 [Refereed]
  
• Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress

  Atsushi Takeda; Miki Suzuki; Haruna Tamano; Shunsuke Takada; Kazuki Ide; Naoto Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 60 (4) 394 - 399 0197-0186 2012/03 [Refereed]
  
• Unique Induction of CA1 LTP Components After Intake of Theanine, an Amino Acid in Tea Leaves and its Effect on Stress Response

  Atsushi Takeda; Haruna Tamano; Miki Suzuki; Kazuhiro Sakamoto; Naoto Oku; Hidehiko Yokogoshi

  CELLULAR AND MOLECULAR NEUROBIOLOGY SPRINGER/PLENUM PUBLISHERS 32 (1) 41 - 48 0272-4340 2012/01 [Refereed]
  
• Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency

  Atsushi Takeda; Haruna Tamano; Taisuke Ogawa; Shunsuke Takada; Masaki Ando; Naoto Oku; Mitsugu Watanabe

  BEHAVIOURAL BRAIN RESEARCH ELSEVIER SCIENCE BV 226 (1) 259 - 264 0166-4328 2012/01 [Refereed]
  
• Design and Synthesis of High-Avidity Tetravalent Glycoclusters as Probes for Sambucus sieboldiana Agglutinin and Characterization of their Binding Properties

  Makoto Ogata; Megumi Yano; Seiichiro Umemura; Takeomi Murata; Enoch Y. Park; Yuka Kobayashi; Tomohiro Asai; Naoto Oku; Naoki Nakamura; Ichiro Matsuo; Taichi Usui

  BIOCONJUGATE CHEMISTRY AMER CHEMICAL SOC 23 (1) 97 - 105 1043-1802 2012/01 [Refereed]
  
• The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo

  Yu Hoshino; Hiroyuki Koide; Keiichi Furuya; Walter W. Haberaecker; Shih-Hui Lee; Takashi Kodama; Hiroaki Kanazawa; Naoto Oku; Kenneth J. Shea

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 109 (1) 33 - 38 0027-8424 2012/01 [Refereed]
  
• Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

  Atsushi Takeda; Shunsuke Takada; Masatoshi Nakamura; Miki Suzuki; Haruna Tamano; Masaki Ando; Naoto Oku

  PLOS ONE PUBLIC LIBRARY SCIENCE 6 (12) e28615  1932-6203 2011/12 [Refereed]
  
• Argonaute2 is a potential target for siRNA-based cancer therapy for HT1080 human fibrosarcoma

  Tatsuaki Tagami; Takuya Suzuki; Kiyomi Hirose; Jose Mario Barichello; Naoshi Yamazaki; Tomohiro Asai; Naoto Oku; Tatsuhiro Ishida; Hiroshi Kiwada

  DRUG DELIVERY AND TRANSLATIONAL RESEARCH SPRINGER HEIDELBERG 1 (4) 277 - 288 2190-393X 2011/08 [Refereed]
  
• Agitation during lipoplex formation improves the gene knockdown effect of siRNA

  Jose Mario Barichello; Shinji Kizuki; Tatsuaki Tagami; Tomohiro Asai; Tatsuhiro Ishida; Hiroshi Kikuchi; Naoto Oku; Hiroshi Kiwada

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 410 (1-2) 153 - 160 0378-5173 2011/05 [Refereed]
  
• Inhibition of Akt (ser473) Phosphorylation and Rapamycin-Resistant Cell Growth by Knockdown of Mammalian Target of Rapamycin with Small Interfering RNA in Vascular Endothelial Growth Factor Receptor-1-Targeting Vector

  Hiroyuki Koide; Tomohiro Asai; Keiichi Furuya; Takuma Tsuzuku; Hiroki Kato; Takehisa Dewa; Mamoru Nango; Noriyuki Maeda; Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 34 (5) 602 - 608 0918-6158 2011/05 [Refereed]
  
• Decoration of fibrinogen gamma-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets

  Koji Tokutomi; Toshiaki Tagawa; Maki Korenaga; Masatoshi Chiba; Tomohiro Asai; Naohide Watanabe; Shinji Takeoka; Makoto Handa; Yasuo Ikeda; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 407 (1-2) 151 - 157 0378-5173 2011/04 [Refereed]
  
• Evaluating tamsulosin hydrochloride-released microparticles prepared using single-step matrix coating

  Atsushi Maeda; Tatsuki Shinoda; Naoki Ito; Keizo Baba; Naoto Oku; Takao Mizumoto

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 408 (1-2) 84 - 90 0378-5173 2011/04 [Refereed]
  
• Proapoptotic Action of p53-Tom5 in p53-Resistant A549 Human Non-small Cell Lung Cancer Cells through Direct Mitochondrial Dysfunction

  Takuya Umemoto; Tomohiro Asai; Koji Hirashima; Kosuke Shimizu; Motohiro Mihara; Koji Yamamoto; Koji Kubota; Shin-ichi Miyagawa; Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 34 (4) 551 - 554 0918-6158 2011/04 [Refereed]
  
• Dicetyl Phosphate-Tetraethylenepentamine-Based Liposomes for Systemic siRNA Delivery

  Tomohiro Asai; Saori Matsushita; Eriya Kenjo; Takuma Tsuzuku; Norihito Yonenaga; Hiroyuki Koide; Kentaro Hatanaka; Takehisa Dewa; Mamoru Nango; Noriyuki Maeda; Hiroshi Kikuchi; Naoto Oku

  BIOCONJUGATE CHEMISTRY AMER CHEMICAL SOC 22 (3) 429 - 435 1043-1802 2011/03 [Refereed]
  
• Anti-angiogenic Activity and Intracellular Distribution of Epigallocatechin-3-gallate Analogs

  Suratsawadee Piyaviriyakul; Kosuke Shimizu; Tomohiro Asakawa; Toshiyuki Kan; Pongpun Siripong; Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 34 (3) 396 - 400 0918-6158 2011/03 [Refereed]
  
• Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416.

  Honda M; Asai T; Umemoto T; Araki Y; Oku N; Tanaka M

  Archives of ophthalmology (Chicago, Ill. : 1960) 129 (3) 317 - 321 0003-9950 2011/03 [Refereed]
  
• Education of graduate school of pharmaceutical sciences in new generation: Introduction

  Noriyasu Hirasawa; Naoto Oku

  Yakugaku Zasshi 131 (6) 931  0031-6903 2011 [Refereed]
  
• PET imaging of brain cancer with positron emitter-labeled liposomes

  Naoto Oku; Mina Yamashita; Yurie Katayama; Takeo Urakami; Kentaro Hatanaka; Kosuke Shimizu; Tomohiro Asai; Hideo Tsukada; Shuji Akai; Hiroaki Kanazawa

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 403 (1-2) 170 - 177 0378-5173 2011/01 [Refereed]
  
• Synthesis of Long-Chain [F-18]Deoxyfluoropoly(ethylene glycol) Methyl Ethers and Their Noninvasive Pharmacokinetic Analysis by Positron Emission Tomography

  Shuji Akai; Sho Ishida; Kentaro Hatanaka; Takayuki Ishii; Norihiro Harada; Hideo Tsukada; Naoto Oku

  MOLECULAR PHARMACEUTICS AMER CHEMICAL SOC 8 (1) 302 - 308 1543-8384 2011/01 [Refereed]
  
• Concise synthesis of catechin probes enabling analysis and imaging of EGCg

  Atsushi Yoshida; Yasuo Hirooka; Yusuke Sugata; Mariko Nitta; Tamiko Manabe; Shunsuke Ido; Kouki Murakami; Repon Kumer Saha; Takashi Suzuki; Motohiro Ohshima; Akira Yoshida; Kunihiko Itoh; Kosuke Shimizu; Naoto Oku; Takumi Furuta; Tomohiro Asakawa; Toshiyuki Wakimoto; Toshiyuki Kan

  CHEMICAL COMMUNICATIONS ROYAL SOC CHEMISTRY 47 (6) 1794 - 1796 1359-7345 2011 [Refereed]
  
• PET imaging of nobiletin based on a practical total synthesis

  Tomohiro Asakawa; Aiki Hiza; Miho Nakayama; Makoto Inai; Dai Oyama; Hiroyuki Koide; Kosuke Shimizu; Toshiyuki Wakimoto; Norihiro Harada; Hideo Tsukada; Naoto Oku; Toshiyuki Kan

  CHEMICAL COMMUNICATIONS ROYAL SOC CHEMISTRY 47 (10) 2868 - 2870 1359-7345 2011 [Refereed]
  
• IMPAIRMENT OF RECOGNITION MEMORY AND HIPPOCAMPAL LONG-TERM POTENTIATION AFTER ACUTE EXPOSURE TO CLIOQUINOL

  A. Takeda; S. Takada; M. Ando; K. Itagaki; H. Tamano; M. Suzuki; H. Iwaki; N. Oku

  NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD 171 (2) 443 - 450 0306-4522 2010/12 [Refereed]
  
• Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78

  Yasufumi Katanasaka; Takayuki Ishii; Tomohiro Asai; Hirotaka Naitou; Noriyuki Maeda; Fumiaki Koizumi; Shinichi Miyagawa; Norio Ohashi; Naoto Oku

  INTERNATIONAL JOURNAL OF CANCER JOHN WILEY & SONS INC 127 (11) 2685 - 2698 0020-7136 2010/12 [Refereed]
  
• Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice

  Haruna Tamano; Fumika Kan; Naoto Oku; Atsushi Takeda

  BRAIN RESEARCH BULLETIN PERGAMON-ELSEVIER SCIENCE LTD 83 (6) 351 - 355 0361-9230 2010/11 [Refereed]
  
• Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin

  Masaki Ando; Naoto Oku; Atsushi Takeda

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 57 (5) 608 - 614 0197-0186 2010/11 [Refereed]
  
• Anti-obesity Effect of Phosphatidylinositol on Diet-Induced Obesity in Mice

  Kosuke Shimizu; Tomoko Ida; Haruhito Tsutsui; Tomohiro Asai; Kazumasa Otsubo; Naoto Oku

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY AMER CHEMICAL SOC 58 (21) 11218 - 11225 0021-8561 2010/11 [Refereed]
  
• Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components

  Atsushi Takeda; Miki Suzuki; Haruna Tamano; Masaki Ando; Naoto Oku

  BRAIN RESEARCH ELSEVIER SCIENCE BV 1354 188 - 195 0006-8993 2010/10 [Refereed]
  
• Liposomalization of hydroxyphenyl fluorescein as a reagent for detecting highly reactive oxygen species

  Ikumi Sugiyama; Saki Kojima; Naoto Oku; Yasuyuki Sadzuka

  Colloid and Polymer Science 288 (12-13) 1293 - 1300 0303-402X 2010/08 [Refereed]
  
• INCREASES IN EXTRACELLULAR ZINC IN THE AMYGDALA IN ACQUISITION AND RECALL OF FEAR EXPERIENCE AND THEIR ROLES IN RESPONSE TO FEAR

  A. Takeda; H. Tamano; S. Imano; N. Oku

  NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD 168 (3) 715 - 722 0306-4522 2010/07 [Refereed]
  
• T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes

  Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Shuji Akai; Takayuki Ishii; Eriya Kenjo; Tatsuhiro Ishida; Hiroshi Kiwada; Hideo Tsukada; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 392 (1-2) 218 - 223 0378-5173 2010/06 [Refereed]
  
• Recognition, Neutralization, and Clearance of Target Peptides in the Bloodstream of Living Mice by Molecularly Imprinted Polymer Nanoparticles: A Plastic Antibody

  Yu Hoshino; Hiroyuki Koide; Takeo Urakami; Hiroaki Kanazawa; Takashi Kodama; Naoto Oku; Kenneth J. Shea

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY AMER CHEMICAL SOC 132 (19) 6644 - + 0002-7863 2010/05 [Refereed]
  
• Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapses

  Atsushi Takeda; Haruka Iwaki; Masaki Ando; Kosuke Itagaki; Miki Suzuki; Naoto Oku

  BRAIN RESEARCH ELSEVIER SCIENCE BV 1323 59 - 64 0006-8993 2010/04 [Refereed]
  
• Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography

  Kentaro Hatanaka; Tomohiro Asai; Hiroyuki Koide; Eriya Kenjo; Takuma Tsuzuku; Norihiro Harada; Hideo Tsukada; Naoto Oku

  BIOCONJUGATE CHEMISTRY AMER CHEMICAL SOC 21 (4) 756 - 763 1043-1802 2010/04 [Refereed]
  
• Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion

  Takayuki Ishii; Tomohiro Asai; Takeo Urakami; Naoto Oku

  BRAIN RESEARCH ELSEVIER SCIENCE BV 1321 (1321) 164 - 168 0006-8993 2010/03 [Refereed]
  
• Literature search on the interaction between warfarin and vitamin K

  Tomomi Fujino; Yoshihiko Ito; Yuko Taki; Nozomi Kakizawa; Satomi Onoue; Yasuyuki Imai; Naoto Oku; Hiroshi Noguchi; Kunihiko Itoh; Hirokazu Kobayashi; Norio Ohashi; Toshinao Goda; Naohide Kinae; Keizo Umegaki; Hiroshi Watanabe; Shizuo Yamada

  Japanese Journal of Clinical Pharmacology and Therapeutics (一社)日本臨床薬理学会 41 (1) 43 - 52 0388-1601 2010/01
• 長鎖[18F]デオキシフルオロPEGの合成とPETイメージングによる体内動態解析

  石田 翔; 畑中剣太朗; 石井貴之; 原田典弘; 塚田秀夫; 奥 直人; 赤井周司

  Progress in Drug Delivery System XIX 41 - 46 2010/01
• Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane

  Kosuke Shimizu; Masaaki Osada; Koji Takemoto; Yutaka Yamamoto; Tomohiro Asai; Naoto Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 141 (2) 208 - 215 0168-3659 2010/01 [Refereed]
  
• A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy

  Yuki Murase; Tomohiro Asai; Yasufumi Katanasaka; Tomoki Sugiyama; Kosuke Shimizu; Noriyuki Maeda; Naoto Oku

  CANCER LETTERS ELSEVIER IRELAND LTD 287 (2) 165 - 171 0304-3835 2010/01 [Refereed]
  
• Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation

  Haruna Tamano; Fumika Kan; Mika Kawamura; Naoto Oku; Atsushi Takeda

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 55 (7) 536 - 541 0197-0186 2009/12 [Refereed]
  
• Elucidation of Accelerated Blood Clearance Phenomenon Caused by Repeat Injection of PEGylated Nanocarriers

  Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Kosuke Shimizu; Masayuki Yokoyama; Tatsuhiro Ishida; Hiroshi Kiwada; Naoto Oku

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN PHARMACEUTICAL SOC JAPAN 129 (12) 1445 - 1451 0031-6903 2009/12 [Refereed]
  
• Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus

  Atsushi Takeda; Naomi Sakurada; Masaki Ando; Shingo Kanno; Naoto Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 55 (6) 376 - 382 0197-0186 2009/11 [Refereed]
  
• Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation

  Atsushi Takeda; Masaki Ando; Shingo Kanno; Naoto Oku

  NEUROTOXICOLOGY ELSEVIER SCIENCE BV 30 (4) 712 - 717 0161-813X 2009/07 [Refereed]
  
• Induction of Apoptosis by Rhinacanthone Isolated from Rhinacanthus nasutus Roots in Human Cervical Carcinoma Cells

  Pongpun Siripong; Chariya hahnvajanawong; Jantana Yahuafai; Suratsawadee Piyaviriyakul; Kwanjai Kanokmedhakul; Ngampong Kongkathip; Somsak Ruchirawat; Naoto Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 32 (7) 1251 - 1260 0918-6158 2009/07 [Refereed]
  
• Design of Synthetic Polymer Nanoparticles that Capture and Neutralize a Toxic Peptide

  Yu Hoshino; Takeo Urakami; Takashi Kodama; Hiroyuki Koide; Naoto Oku; Yoshio Okahata; Kenneth J. Shea

  SMALL WILEY-V C H VERLAG GMBH 5 (13) 1562 - 1568 1613-6810 2009/07 [Refereed]
  
• High K+-induced Increase in Extracellular Glutamate in Zinc Deficiency and Endogenous Zinc Action

  Atsushi Takeda; Hiromasa Itoh; Haruna Tamano; Naoto Oku

  JOURNAL OF HEALTH SCIENCE PHARMACEUTICAL SOC JAPAN 55 (3) 405 - 412 1344-9702 2009/06 [Refereed]
  
• Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography

  Takeo Urakami; Koichi Sakai; Tomohiro Asai; Dai Fukumoto; Hideo Tsukada; Naoto Oku

  NUCLEAR MEDICINE AND BIOLOGY ELSEVIER SCIENCE INC 36 (3) 295 - 303 0969-8051 2009/04 [Refereed]
  
• In Vivo Distribution of Liposome-Encapsulated Hemoglobin Determined by Positron Emission Tomography

  Takeo Urakami; Akira T. Kawaguchi; Shuji Akai; Kentaro Hatanaka; Hiroyuki Koide; Kosuke Shimizu; Tomohiro Asai; Dai Fukumoto; Norihiro Harada; Hideo Tsukada; Naoto Oku

  ARTIFICIAL ORGANS WILEY-BLACKWELL PUBLISHING, INC 33 (2) 164 - 168 0160-564X 2009/02 [Refereed]
  
• Identification of melanoma-specific serological markers using proteomic analyses

  Masako Takikawa; Yasuto Akiyama; Tadashi Ashizawa; Akifumi Yamamoto; Naoya Yamazaki; Yoshio Kiyohara; Naoto Oku; Ken Yamaguchi

  Proteomics - Clinical Applications 3 (5) 552 - 562 1862-8346 2009 [Refereed]
  
• POSITIVE MODULATION OF LONG-TERM POTENTIATION AT HIPPOCAMPAL CA1 SYNAPSES BY LOW MICROMOLAR CONCENTRATIONS OF ZINC

  A. Takeda; S. Fuke; M. Ando; N. Oku

  NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD 158 (2) 585 - 591 0306-4522 2009/01 [Refereed]
  
• ANTIANGIOGENIC PHOTODYNAMIC THERAPY WITH TARGETED LIPOSOMES

  Naoto Oku; Takayuki Ishii

  METHODS IN ENZYMOLOGY LIPOSOMES, PT G ELSEVIER ACADEMIC PRESS INC 465 313 - 330 0076-6879 2009 [Refereed]
  
• In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography.

  Urakami T; Kawaguchi AT; Akai S; Hatanaka K; Koide H; Shimizu K; Asai T; Fukumoto D; Harada N; Tsukada H; Oku N

  (53) 709 - 717 2009 [Refereed]
  
• Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan

  Atsushi Takeda; Haruna Tamano; Hiromasa Itoh; Naoto Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 53 (6-8) 230 - 235 0197-0186 2008/12 [Refereed]
  
• Antineovascular Gene Therapy by Ago2 Knockdown

  Kentaro Hatanaka; Kosuke Shimizu; Tomohiro Asai; Naoto Oku

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN PHARMACEUTICAL SOC JAPAN 128 (11) 1567 - 1575 0031-6903 2008/11 [Refereed]
  
• Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416

  Yasufumi Katanasaka; Tomoko Ida; Tomohiro Asai; Kosuke Shimizu; Fumiaki Koizumi; Noriyuki Maeda; Kazuhiko Baba; Naoto Oku

  CANCER LETTERS ELSEVIER IRELAND LTD 270 (2) 260 - 268 0304-3835 2008/11 [Refereed]
  
• Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc

  Atsushi Takeda; Shingo Kanno; Naomi Sakurada; Masaki Ando; Naoto Oku

  JOURNAL OF NEUROSCIENCE RESEARCH WILEY-LISS 86 (13) 2906 - 2911 0360-4012 2008/10 [Refereed]
  
• Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on behavior

  Atsushi Takeda; Hiromasa Itoh; Kohei Yamada; Haruna Tamano; Naoto Oku

  BIOMETALS SPRINGER 21 (5) 545 - 552 0966-0844 2008/10 [Refereed]
  
• Particle size-dependent triggering of accelerated blood clearance phenomenon

  Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Takeo Urakami; Takayuki Ishii; Eriya Kenjo; Masamichi Nishihara; Masayuki Yokoyama; Tatsuhiro Ishida; Hiroshi Kiwada; Naoto Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 362 (1-2) 197 - 200 0378-5173 2008/10 [Refereed]
  
• Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes

  Y. Katanasaka; T. Ida; T. Asai; N. Maeda; N. Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 360 (1-2) 219 - 224 0378-5173 2008/08 [Refereed]
  
• Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC

  Tomohiro Asai; Souichiro Miyazawa; Noriyuki Maeda; Kentaro Hatanaka; Yasufumi Katanasaka; Kosuke Shimizu; Satoshi Shuto; Naoto Oku

  CANCER SCIENCE BLACKWELL PUBLISHING 99 (5) 1029 - 1033 1347-9032 2008/05 [Refereed]
  
• Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency

  Atsushi Takeda; Haruna Tamano; Fumika Kan; Tomoyuki Hanajima; Kohei Yamada; Naoto Oku

  LIFE SCIENCES PERGAMON-ELSEVIER SCIENCE LTD 82 (17-18) 909 - 914 0024-3205 2008/04 [Refereed]
  
• Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown

  Tomohiro Asai; Yuko Suzuki; Saori Matsushita; Sei Yonezawa; Junichi Yokota; Yasufumi Katanasaka; Tatsuhiro Ishida; Takehisa Dewa; Hiroshi Kiwada; Mamoru Nango; Naoto Oku

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 368 (2) 243 - 248 0006-291X 2008/04 [Refereed]
  
• A new approach for drug discovery from glycobiology and phage-displayed peptide library technology

  Takao Taki; Dai Ishikawa; Koichi Ogino; Michinori Tanaka; Naoto Oku; Tomohiro Asai; Iuliana Popa; Jacques Portoukallan

  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS ELSEVIER SCIENCE BV 1780 (3) 497 - 503 0304-4165 2008/03 [Refereed]
  
• Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats

  Atsushi Takeda; Hiromasa Itoh; Haruna Tamano; Mitsutoshi Yuzurihara; Naoto Oku

  NUTRITIONAL NEUROSCIENCE MANEY PUBLISHING 11 (1) 41 - 46 1028-415X 2008/02 [Refereed]
  
• Vulnerability to seizures induced by potassium dyshomeostasis in the hippocampus in aged rats

  Atsushi Takeda; Naomi Sakurada; Shingo Kanno; Masaki Ando; Naoto Oku

  JOURNAL OF HEALTH SCIENCE PHARMACEUTICAL SOC JAPAN 54 (1) 37 - 42 1344-9702 2008/02 [Refereed]
  
• Imaging technology for the research and the development of DDS nanocarriers and nanomedicines

  Takeo Urakami; Naoto Oku

  Drug Delivery System 23 (1) 40 - 48 1881-2732 2008 [Refereed]
  
• Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency

  Atsushi Takeda; Kohei Yamada; Haruna Tamano; Sayuri Fuke; Mika Kawamura; Naoto Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 52 (1-2) 241 - 246 0197-0186 2008/01 [Refereed]
  
• Enhancement of antitumor activity of OK-432 (Picibanil) by Triton X-114 phase partitioning

  Masahito Hashimoto; Katsuhiro Takashige; Maiko Furuyashiki; Keitaro Yoshidome; Ryoko Sano; Yutaka Kawamura; Shinji Ijichi; Hirofumi Morioka; Hiroyuki Koide; Naoto Oku; Yoichiro Moriya; Shoich Kusumoto; Yasuo Suda

  INTERNATIONAL IMMUNOPHARMACOLOGY ELSEVIER SCIENCE BV 8 (1) 12 - 19 1567-5769 2008/01 [Refereed]
  
• Chronopharmacologic cancer treatment with an angiogenic vessel-targeted liposomal drug.

  Shimizu K; Sawazaki Y; Tanaka T; Asai T; Oku N

  Biol. Pharm. Bull. (31) 95 - 98 2008 [Refereed]
  
• Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake.

  Imanaka H; Koide H; Shimizu K; Asai T; Kinouchi Shimizu N; Ishikado A; Makino T; Oku N

  Biol. Pharm. Bull (31) 400 - 404 2008 [Refereed]
  
• Enhanced experimental tumor metastasis with age in senescence-accelerated mouse.

  Shimizu K; Kinouchi Shimizu N; Asai T; Tsukada H; Oku N

  Biol. Pharm. Bull. (31) 847 - 851 2008 [Refereed]
  
• Negative modulation of presynaptic activitv by zinc released from Schaffer collaterals

  Atsushi Takeda; Sayuri Fuke; Wataru Tsutsumi; Naoto Oku

  JOURNAL OF NEUROSCIENCE RESEARCH WILEY 85 (16) 3666 - 3672 0360-4012 2007/12 [Refereed]
  
• Novel amphiphilic probes for [F-18]-radiolabeling preformed liposomes and determination of liposomal trafficking by positron emission tomography

  Takeo Urakami; Shuji Akai; Yurie Katayama; Norihiro Harada; Hideo Tsukada; Naoto Oku

  JOURNAL OF MEDICINAL CHEMISTRY AMER CHEMICAL SOC 50 (26) 6454 - 6457 0022-2623 2007/12 [Refereed]
  
• Dorsal Air Sac Model

  Sei Yonezawa; Tomohiro Asai; Naoto Oku

  Angiogenesis Assays: A Critical Appraisal of Current Techniques John Wiley & Sons, Ltd 229 - 238 2007/09 [Refereed]
  
• Decline in glutathione peroxidase activity is a reason for brain senescence: Consumption of green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain

  Takahiro Kishido; Keiko Unno; Hirotoshi Yoshida; Daisuke Choba; Rie Fukutomi; Shunsuke Asahina; Kazuaki Iguchi; Naoto Oku; Minoru Hoshino

  Biogerontology 8 (4) 423 - 430 1389-5729 2007/08 [Refereed]
  
• Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release

  Atsushi Takeda; Sayuri Fuke; Akira Minami; Naoto Oku

  JOURNAL OF NEUROSCIENCE RESEARCH WILEY-LISS 85 (6) 1310 - 1317 0360-4012 2007/05 [Refereed]
  
• Enhanced desensitization efficacy by liposomal conjugation of a specific antigen

  K. Ichikawa; T. Urakami; S. Yonezawa; H. Miyauchi; K. Shimizu; T. Asai; N. Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 336 (2) 391 - 395 0378-5173 2007/05 [Refereed]
  
• Daily consumption of green tea catechin delays memory regression in aged mice

  Keiko Unno; Fumiyo Takabayashi; Hirotoshi Yoshida; Daisuke Choba; Rie Fukutomi; Naomi Kikunaga; Takahiro Kishido; Naoto Oku; Minoru Hoshino

  Biogerontology 8 (2) 89 - 95 1389-5729 2007/04 [Refereed]
  
• Effective tumor regression by anti-neovascular therapy in hypovascular orthotopic pancreatic tumor model

  Sei Yonezawa; Tomohiro Asai; Naoto Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 118 (3) 303 - 309 0168-3659 2007/04 [Refereed]
  
• Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma

  Chiaki Fuse; Yuuki Ishida; Tomoya Hikita; Tomohiro Asai; Naoto Oku

  JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 282 (11) 8276 - 8283 0021-9258 2007/03 [Refereed]
  
• Anxiety-like behavior of young rats after 2-week zinc deprivation

  Atsushi Takeda; Haruna Tamano; Fumika Kan; Hiromasa Itoh; Naoto Oku

  BEHAVIOURAL BRAIN RESEARCH ELSEVIER SCIENCE BV 177 (1) 1 - 6 0166-4328 2007/02 [Refereed]
  
• Analysis of brain muscarinic receptor binding after administration of anticholinergic agents for the treatment of overactive bladder, in conscious rhesus monkey by positron emission tomography (PET)

  Shuji Maruyama; Hideo Tsukada; Shingo Nishiyama; Norihiro Harada; Takeharu Kakiuchi; Hiroyuki Ohba; Dai Fukumoto; Naoto Oku; Shizuo Yamada

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN PHARMACEUTICAL SOC JAPAN 127 133 - 136 0031-6903 2007 [Refereed]
  
• Effect of long-term tea catechin-intake on experimental metastatic potential

  Naoto Oku; Kosuke Shimizu; Naomi Kinouchi Shimizu; Hideo Tsukada

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN PHARMACEUTICAL SOC JAPAN 127 43 - 45 0031-6903 2007 [Refereed]
  
• Response of hippocampal mossy fiber zinc to excessive glutamate release

  Atsushi Takeda; Akira Minami; Naomi Sakurada; Satoko Nakajima; Naoto Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 50 (2) 322 - 327 0197-0186 2007/01 [Refereed]
  
• Proteomic characterization of angiogenic endothelial cells stimulated with cancer cell-conditioned medium.

  Katanasaka Y; Asai T; Naitou H; Ohashi N; Oku N

  Biol. Pharm. Bull. (30) 2300 - 2307 2007 [Refereed]
  
• Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation

  Atsushi Takeda; Hiromasa Itoh; Sachie Imano; Naoto Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 49 (8) 746 - 750 0197-0186 2006/12 [Refereed]
  
• Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortex

  Atsushi Takeda; Sachie Imano; Hiromasa Itoh; Naoto Oku

  BRAIN RESEARCH ELSEVIER SCIENCE BV 1118 52 - 57 0006-8993 2006/11 [Refereed]
  
• Responsiveness to kainate in young rats after 2-week zinc deprivation

  Atsushi Takeda; Hiromasa Itoh; Haruna Tamano; Naoto Oku

  BIOMETALS SPRINGER 19 (5) 565 - 572 0966-0844 2006/10 [Refereed]
  
• Response of extracelluar zinc in the ventral hippocampus against novelty stress

  Atsushi Takeda; Naomi Sakurada; Shingo Kanno; Akira Minami; Naoto Oku

  JOURNAL OF NEUROCHEMISTRY WILEY 99 (2) 670 - 676 0022-3042 2006/10 [Refereed]
  
• Zinc release from Schaffer collaterals and its significance

  A Takeda; S Nakajima; S Fuke; N Sakurada; A Minami; N Oku

  BRAIN RESEARCH BULLETIN PERGAMON-ELSEVIER SCIENCE LTD 68 (6) 442 - 447 0361-9230 2006/02 [Refereed]
  
• Antiproliferative naphthoquinone esters from Rhinacanthus nasutus kurz. roots on various cancer cells

  Pongpun Siripong; Kwanjai Kanokmedakul; Suratsawadee Piyaviriyagul; Jantana Yahuafai; Rittichai Chanpai; Somsak Ruchirawat; Naoto Oku

  Journal of Traditional Medicines 23 (5) 166 - 172 1881-3747 2006 [Refereed]
  
• Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation

  A Minami; N Sakurada; S Fuke; K Kikuchi; T Nagano; N Oku; A Takeda

  JOURNAL OF NEUROSCIENCE RESEARCH WILEY-LISS 83 (1) 167 - 176 0360-4012 2006/01 [Refereed]
  
• Enhancement of anticancer activity in antineovascular therapy is based on the intratumoral distribution of the active targeting carrier for anticancer drugs.

  Maeda N; Miyazawa S; Shimizu K; Asai T; Yonezawa S; Kitazawa S; Namba Y; Tsukada H; Oku N

  Biol. Pharm. Bull. (29) 1936 - 1940 2006 [Refereed]
  
• Induction of apoptosis in tumor cells by three naphthoquinone esters isolated from thai medicinal plant: Rhinacanthus nasutus KURZ.

  Siripong P; Yahuafai J; Shimizu K; Ichikawa K; Yonezawa S; Asai T; Kanokmedakul K; Ruchirawat S; Oku N

  Biol. Pharm. Bull. (29) 2070 - 2076 2006 [Refereed]
  
• Antitumor activity of liposomal naphthoquinone esters isolated from thai medicinal plant: Rhinacanthus nasutus Kurz

  Siripong P; Yahuafai J; Shimizu K; Ichikawa K; Yonezawa S; Asai T; Kanokmedakul K; Ruchirawat S; Oku N

  Biol. Pharm. Bull (29) 2279 - 2283 2006 [Refereed]
  
• Increase in hippocampal cell death after treatment with kainate in zinc deficiency

  A Takeda; H Tamano; A Nagayoshi; K Yamada; N Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 47 (8) 539 - 544 0197-0186 2005/12 [Refereed]
  
• Involvement of unusual glutamate release in kainate-induced seizures in zinc-deficient adult rats

  A Takeda; H Tamano; N Oku

  EPILEPSY RESEARCH ELSEVIER SCIENCE BV 66 (1-3) 137 - 143 0920-1211 2005/08 [Refereed]
  
• Antiangiogenic photodynamic therapy (PDT) by using long-circulating liposomes modified with peptide specific to angiogenic vessels

  K Ichikawa; T Hikita; N Maeda; S Yonezawa; Y Takeuchi; T Asai; Y Namba; N Oku

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES ELSEVIER SCIENCE BV 1669 (1) 69 - 74 0005-2736 2005/05 [Refereed]
  
• Applicability of anti-neovascular therapy to drug-resistant tumor: Suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin

  K Shimizu; T Asai; C Fuse; Y Sadzuka; T Sonobe; K Ogino; T Taki; T Tanaka; N Oku

  INTERNATIONAL JOURNAL OF PHARMACEUTICS ELSEVIER SCIENCE BV 296 (1-2) 133 - 141 0378-5173 2005/05 [Refereed]
  
• A new and known cytotoxic aryltetralin-type lignans from stems of Bursera graveolens

  Tsutomu Nakanishi; Yuka Inatomi; Hiroko Murata; Kaori Shigeta; Naoki Iida; Akira Inada; Jin Murata; Miguel Angel Perez Farrera; Munekazu Iinuma; Toshiyuki Tanaka; Shogo Tajima; Naoto Oku

  Chemical and Pharmaceutical Bulletin 53 (2) 229 - 231 0009-2363 2005/02 [Refereed]
  
• Zinc homeostasis in the hippocampus of zinc-deficient young adult rats

  A Takeda; H Tamano; M Tochigi; N Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 46 (3) 221 - 225 0197-0186 2005/02 [Refereed]
  
• Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency

  A Takeda; K Yamada; A Minami; T Nagano; N Oku

  EPILEPSY RESEARCH ELSEVIER SCIENCE BV 63 (2-3) 77 - 84 0920-1211 2005/02 [Refereed]
  
• Antineovascular therapy, a novel antiangiogenic approach

  K Shimizu; T Asai; N Oku

  EXPERT OPINION ON THERAPEUTIC TARGETS ASHLEY PUBLICATIONS LTD 9 (1) 63 - 76 1472-8222 2005/02 [Refereed]
  
• Functional analysis of junctional adhesion molecule (JAM) in cancer metastasis

  T Hikita; Y Ishida; C Fuse; A Turuta; T Asai; N Oku

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN PHARMACEUTICAL SOC JAPAN 125 74 - 75 0031-6903 2005 [Refereed]
  
• Glucuronate-modified, long-circulating liposomes for the delivery of anticancer agents

  N Oku; Y Namba

  LIPOSOMES, PT E ELSEVIER ACADEMIC PRESS INC 391 145 - + 0076-6879 2005 [Refereed]
  
• Liposomalized oligopeptides in cancer therapy

  T Asai; N Oku

  LIPOSOMES, PT E ELSEVIER ACADEMIC PRESS INC 391 163 - + 0076-6879 2005 [Refereed]
  
• Proteomic analysis of membrane proteins of angiogenic endothelial cells

  Y Katanasaka; T Asai; H Naitou; N Ohashi; N Oku

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN PHARMACEUTICAL SOC JAPAN 125 72 - 73 0031-6903 2005
• Novel polyamine-dialkyl phosphate conjugates for gene carriers. facile synthetic route via an unprecedented dialkyl phosphate

  Takehisa Dewa; Yukari Ieda; Kazuyuki Morita; Li Wang; Robert C. MacDonald; Kouji Iida; Keiji Yamashita; Naoto Oku; Mamoru Nango

  Bioconjugate Chemistry 15 (4) 824 - 830 1043-1802 2004/07 [Refereed]
  
• Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10)

  Keiko Unno; Fumiyo Takabayashi; Takahiro Kishido; Naoto Oku

  Experimental Gerontology 39 (7) 1027 - 1034 0531-5565 2004/07 [Refereed]
  
• (-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis

  S Yamakawa; T Asai; T Uchida; M Matsukawa; T Akizawa; N Oku

  CANCER LETTERS ELSEVIER SCI IRELAND LTD 210 (1) 47 - 55 0304-3835 2004/07 [Refereed]
  
• Suppressed permeation of linoleic acid in a liposomal formulation through reconstructed skin tissue

  Y Shigeta; H Imanaka; S Yonezawa; N Oku; N Baba; T Makino

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 27 (6) 879 - 882 0918-6158 2004/06 [Refereed]
  
• Intracellular target for photo sensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome

  Y Takeuchi; K Ichikawa; S Yonezawa; K Kurohane; T Koishi; M Nango; Y Namba; N Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 97 (2) 231 - 240 0168-3659 2004/06 [Refereed]
  
• In vivo trafficking of endothelial progenitor cells and their possible involvement in tumor neovascularization

  M Tamura; K Unno; S Yonezawa; K Hattori; E Nakashima; H Tsukada; M Nakajima; N Oku

  LIFE SCIENCES PERGAMON-ELSEVIER SCIENCE LTD 75 (5) 575 - 584 0024-3205 2004/06
• Cancer anti-angiogenic therapy

  K Shimizu; N Oku

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 27 (5) 599 - 605 0918-6158 2004/05 [Refereed]
  
• Skin whitening effect of linoleic acid is enhanced by liposomal formulations

  Yasutami Shigeta; Hiromichi Imanaka; Hideya Ando; Atsuko Ryu; Naoto Oku; Naomichi Baba; Taketoshi Makino

  Biological and Pharmaceutical Bulletin 27 (4) 591 - 594 0918-6158 2004/04 [Refereed]
  
• Elimination of zinc-65 from the brain under kainate-induced seizures

  A Takeda; M Hirate; N Oku

  BIOMETALS SPRINGER 17 (2) 141 - 144 0966-0844 2004/04 [Refereed]
  
• Release of amino acids by zinc in the hippocampus

  A Takeda; A Minami; Y Seki; S Nakajima; N Oku

  BRAIN RESEARCH BULLETIN PERGAMON-ELSEVIER SCIENCE LTD 63 (3) 253 - 257 0361-9230 2004/04 [Refereed]
  
• Involvement of amygdalar extracellular zinc in rat behavior for passive avoidance

  A Takeda; A Minami; R Yamaide; N Oku

  NEUROSCIENCE LETTERS ELSEVIER IRELAND LTD 358 (2) 119 - 122 0304-3940 2004/03 [Refereed]
  
• Antiangiogenic photodynamic therapy (PDT) using Visudyne causes effective suppression of tumor growth

  K Ichikawa; Y Takeuchi; S Yonezawa; T Hikita; K Kurohane; Y Namba; N Oku

  CANCER LETTERS ELSEVIER IRELAND LTD 205 (1) 39 - 48 0304-3835 2004/03 [Refereed]
  
• Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate

  Noriyuki Maeda; Yoshito Takeuchi; Miki Takada; Yukihiro Namba; Naoto Oku

  Bioorganic and Medicinal Chemistry Letters Elsevier Ltd 14 (4) 1015 - 1017 0960-894X 2004/02 [Refereed]
  
• Improvement in brain function and oxidative damage of aged senescence-accelerated mice by green tea catechins

  Keiko Unno; Fumiyo Takabayashi; Naoto Oku

  International Congress Series 1260 (C) 409 - 412 0531-5131 2004/02 [Refereed]
  
• Anti-neovascular therapy by targeted liposomes

  Tomohiro Asai; Naoto Oku

  Drug Delivery System 19 (6) 488 - 494 1881-2732 2004 [Refereed]
  
• Novel polycationic phospholipid conjugates for gene carriers

  Takehisa Dewa; Yukari Ieda; Kazuyuki Morita; Kiyotaka Yoshida; Li Wang; Robert C. MacDonald; Kouji Iida; Keiji Yamashita; Naoto Oku; Mamoru Nango

  Kobunshi Ronbunshu Society of Polymer Science 61 (12) 634 - 639 0386-2186 2004 [Refereed]
  
• Possible mechanism of polycation liposome (PCL)-mediated gene transfer

  M Sugiyama; M Matsuura; Y Takeuchi; J Kosaka; M Nango; N Oku

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES ELSEVIER SCIENCE BV 1660 (1-2) 24 - 30 0005-2736 2004/01 [Refereed]
  
• Differential effects of Zinc on Glutamatergic and GABAergic neurotransmitter systems in the hippocampus

  A Takeda; A Minami; Y Seki; N Oku

  JOURNAL OF NEUROSCIENCE RESEARCH WILEY 75 (2) 225 - 229 0360-4012 2004/01 [Refereed]
  
• Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase

  M Kondo; T Asai; Y Katanasaka; Y Sadzuka; H Tsukada; K Ogino; T Taki; K Baba; N Oku

  INTERNATIONAL JOURNAL OF CANCER WILEY-LISS 108 (2) 301 - 306 0020-7136 2004/01 [Refereed]
  
• Inhibitory function of zinc against excitation of hippocampal glutamatergic neurons

  A Takeda; A Minami; Y Seki; N Oku

  EPILEPSY RESEARCH ELSEVIER SCIENCE BV 57 (2-3) 169 - 174 0920-1211 2003/12 [Refereed]
  
• Polycation liposome enhances the endocytic uptake of photosensitizer into cells in the presence of serum

  Y Takeuchi; K Kurohane; K Ichikawa; S Yonezawa; H Ori; T Koishi; M Nango; N Oku

  BIOCONJUGATE CHEMISTRY AMER CHEMICAL SOC 14 (4) 790 - 796 1043-1802 2003/07 [Refereed]
  
• Polycation liposome-mediated gene transfer in vivo

  M Matsuura; Y Yamazaki; M Sugiyama; M Kondo; H Ori; M Nango; N Oku

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES ELSEVIER SCIENCE BV 1612 (2) 136 - 143 0005-2736 2003/06 [Refereed]
  
• Susceptibility to kainate-induced seizures under dietary zinc deficiency

  A Takeda; M Hirate; H Tamano; D Nisibaba; N Oku

  JOURNAL OF NEUROCHEMISTRY WILEY 85 (6) 1575 - 1580 0022-3042 2003/06 [Refereed]
  
• Release of glutamate and GABA in the hippocampus under zinc deficiency

  A Takeda; M Hirate; H Tamano; N Oku

  JOURNAL OF NEUROSCIENCE RESEARCH WILEY 72 (4) 537 - 542 0360-4012 2003/05 [Refereed]
  
• Zinc movement in the brain under kainate-induced seizures

  A Takeda; M Hirate; H Tamano; N Oku

  EPILEPSY RESEARCH ELSEVIER SCIENCE BV 54 (2-3) 123 - 129 0920-1211 2003/05 [Refereed]
  
• Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity

  S Minato; K Iwanaga; M Kakemi; S Yamashita; N Oku

  JOURNAL OF CONTROLLED RELEASE ELSEVIER SCIENCE BV 89 (2) 189 - 197 0168-3659 2003/04 [Refereed]
  
• Induction of intensive tumor suppression by antiangiogenic photodynamic therapy using polycation-modified liposomal photosensitizer

  Y Takeuchi; K Kurohane; K Ichikawa; S Yonezawa; M Nango; N Oku

  CANCER JOHN WILEY & SONS INC 97 (8) 2027 - 2034 0008-543X 2003/04 [Refereed]
  
• Alteration of zinc concentrations in the brain implanted with C6 glioma

  A Takeda; H Tamano; N Oku

  BRAIN RESEARCH ELSEVIER SCIENCE BV 965 (1-2) 170 - 173 0006-8993 2003/03 [Refereed]
  
• Influence of manganese on the release of neurotransmitters in rat striatum

  A Takeda; N Sotogaku; N Oku

  BRAIN RESEARCH ELSEVIER SCIENCE BV 965 (1-2) 279 - 282 0006-8993 2003/03 [Refereed]
  
• Increased expression of Hsp70 for resistance to deuterium oxide in a yeast mutant cell line

  Keiko Unno; Takahiro Kishido; Mizue Morioka; Shoji Okada; Naoto Oku

  Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 26 (6) 799 - 802 0918-6158 2003 [Refereed]
  
• In vivo recognition of cyclopentadienyltricarbonylrhenium (CpTR) derivatives

  Tomoya Uehara; Miho Koike; Hideo Nakata; Shigehiko Miyamoto; Shoji Motoishi; Kazuyuki Hashimoto; Naoto Oku; Morio Nakayama; Yasushi Arano

  Nuclear Medicine and Biology Elsevier Inc. 30 (3) 327 - 334 0969-8051 2003 [Refereed]
  
• Anti-neovascular therapy by use of liposomes targeted to angiogenic vessels

  N Oku; T Asai; K Watanabe; K Kuromi; K Ogino; T Taki

  JOURNAL OF LIPOSOME RESEARCH MARCEL DEKKER INC 13 (1) 25 - 27 0898-2104 2003 [Refereed]
  
• Neuromodulatory action of zinc in the release of neurotransmitters.

  Takeda A; Minami A; Oku N

  Biomedical Research on Trace Elements 14 287 - 289 2003 [Refereed]
  
• Possible involvement of plasma histidine in differential brain permeability to zinc and cadmium

  A Takeda; M Suzuki; N Oku

  BIOMETALS KLUWER ACADEMIC PUBL 15 (4) 371 - 375 0966-0844 2002/12 [Refereed]
  
• Influence of iron-saturation of plasma transferrin in iron distribution in the brain

  A Takeda; K Takatsuka; N Sotogaku; N Oku

  NEUROCHEMISTRY INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD 41 (4) 223 - 228 0197-0186 2002/10 [Refereed]
  
• Distribution of trace elements in the brain of EL (epilepsy) mice

  M Hirate; A Takeda; H Tamano; S Enomoto; N Oku

  EPILEPSY RESEARCH ELSEVIER SCIENCE BV 51 (1-2) 109 - 116 0920-1211 2002/09 [Refereed]
  
• Preferential uptake of zinc, manganese, and rubidium in rat brain tumor

  H Tamano; S Enomoto; N Oku; A Takeda

  NUCLEAR MEDICINE AND BIOLOGY ELSEVIER SCIENCE INC 29 (4) 505 - 508 0969-8051 2002/05 [Refereed]
  
• Manganese influences the levels of neurotransmitters in synapses in rat brain

  A Takeda; N Sotogaku; N Oku

  NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD 114 (3) 669 - 674 0306-4522 2002 [Refereed]
  
• Cancer antineovascular therapy

  N Oku; T Asai; K Kurohane; K Watanabe; K Kuromi; Y Namba; K Ogino; T Taki

  CELLULAR & MOLECULAR BIOLOGY LETTERS CELLULAR & MOLECULAR BIOLOGY LETTERS 7 (2) 247 - 248 1425-8153 2002 [Refereed]
  
• Intensive tumor suppression by anti-angiogenic photodynamic therapy with polycation-modified liposomal photosensitizer.

  Takeuchi Y; Kurohane K; Nango M; Oku N

  Cellular & molecular biology letters 7 (2) 301  1425-8153 2002 [Refereed]
  
• Zinc functions in synapses in the brain.

  Minami A; Takeda A; Oku N

  Biomedical Research on Trace Elements 12 263 - 264 2001 [Refereed]
  
• Enhanced susceptibility to epileptic seizures under zinc deficiency.

  Takeda A; Hirate M; Minami A; Oku N

  Neuroscience Research S25,S164  2001 [Refereed]
  
• Cadmium action in synapses in the brain.

  Minami A; Takeda A; Nishibaba D; Takefuta S; Oku N

  Riken Review 35 59 - 63 2001 [Refereed]
  
• Liposomes modified with a synthetic Arg-Gly-Asp mimetic inhibit lung metastasis of B16BL6 melanoma cells

  K Kurohane; Y Namba; N Oku

  LIFE SCIENCES PERGAMON-ELSEVIER SCIENCE LTD 68 (3) 273 - 281 0024-3205 2000/12 [Refereed]
  
• Usefulness of positron emission tomographic visualization for examination of in vivo susceptibility to metastasis

  H Kikkawa; H Tsukada; N Oku

  CANCER WILEY-BLACKWELL 89 (7) 1626 - 1633 0008-543X 2000/10 [Refereed]
  
• Development of a simple cell invasion assay system

  Satoru Yamakawa; Yukihiro Furuyama; Naoto Oku

  Biological and Pharmaceutical Bulletin Pharmaceutical Society of Japan 23 (10) 1264 - 1266 0918-6158 2000 [Refereed]
  
• Transport and action of cadmium and zinc in rat brain

  S Takefuta; A Takeda; H Ijiro; M Ohnuma; J Sawashita; S Okada; N Oku

  JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH PHARMACEUTICAL SOC JAPAN 45 (1) P14 - P14 0013-273X 1999/02 [Refereed]
  
• Transport and Action of Cadmium and Zinc in Rat Brain

  Sachiyo Takefuta; Atsushi Takeda; Hiromi Ijiro; Miho Ohnuma; Jinko Sawashita; Shoji Okada; Naoto Oku

  Journal of Health Science 45 (1) 14  1347-5207 1999 [Refereed]
  
• Role of sialylglycoconjugate(s) in the initial phase of metastasis of liver-metastatic RAW117 lymphoma cells

  H Kikkawa; D Miyamoto; H Imafuku; C Koike; Y Suzuki; S Okada; H Tsukada; T Irimura; N Oku

  JAPANESE JOURNAL OF CANCER RESEARCH ELSEVIER SCI IRELAND LTD 89 (12) 1296 - 1305 0910-5050 1998/12 [Refereed]
  
• Antitumor activity of res-avoiding liposomal 5′-dipalmitoylphosphatidyl 2′-C-Cyano-2′-deoxy-1-β-D-arabino-pentofuranosylcytosine(DPP-CNDAC)

  Tomohiro Asai; Naoto Oku; Kohta Kurohane; Yukino Yuyama; Shoji Okada; Satoshi Shuto; Hirokazu Awano; Akira Matsuda

  Drug Delivery System 13 (5) 341 - 346 1881-2732 1998 [Refereed]
  
• TRANSPORT MECHANISMS OF MONOCARBOXYLIC ACID DRUGS THROUGH THE LIPID BILAYER

  TAKAGI Masanori; YAMASHITA Shinji; TAKI Yoko; SAKANE Toshiyasu; SEZAKI Hitoshi; NADAI Tanekazu; NISHI Masatoshi; SUGIHARA Masahisa; OKU Naoto

  Drug Metabolism and Pharmacokinetics The Japanese Society for the Study of Xenobiotics 12 72 - 73 0916-1139 1997/10
• IMPROVEMENT OF GASTROINTESTINAL ABSORPTION OF PEPTIDE DRUGS BY USING SURFACE COATING LIPOSOMES

  IWANAGA Kazunori; ONO Satoshi; NARIOKA Kohji; MORIMOTO Kazuhiro; KAKEMI Masawo; YAMASHITA Shinji; OKU Naoto

  Drug Metabolism and Pharmacokinetics The Japanese Society for the Study of Xenobiotics 12 86 - 87 0916-1139 1997
• Involvement of metabolic methylation in arsenic-induced mutagenesis for mammalian cells

  O. Misawa; K. Kato; K. Yamanaka; A. Hasegawa; N. Oku; S. Okada

  Japanese Journal of Toxicology and Environmental Health Pharmaceutical Society of Japan 43 (1) P11  0013-273X 1997 [Refereed]
  
• Effect of serum protein binding on real-time trafficking of liposomes with different charges analyzed by positron emission tomography

  Naoto Oku; Yoshihiro Tokudome; Yukihiro Namba; Nobuko Saito; Masae Endo; Yoko Hasegawa; Mayumi Kawai; Hideo Tsukada; Shoji Okada

  Biochimica et Biophysica Acta - Biomembranes Elsevier B.V. 1280 (1) 149 - 154 0005-2736 1996/04 [Refereed]
  
• 転移性癌細胞の生体内動態におけるインテグリンの関与 PETを用いた解析

  滝口 綾乃; 小池 千恵子; 奥 直人; 岡田 昌二; 松浦 成昭; 入村 達郎; 塚田 秀夫; 垣内 岳春

  日本薬学会年会要旨集 (公社)日本薬学会 116年会 (3) 122 - 122 0918-9823 1996/03
• Antitumor activity of vincristine encapsulated in glucuronide-modified long-circulating liposomes in mice bearing Meth A sarcoma

  Y Tokudome; N Oku; K Doi; Y Namba; S Okada

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES ELSEVIER SCIENCE BV 1279 (1) 70 - 74 0005-2736 1996/02 [Refereed]
  
• Liposomal trafficking in normal and tumor-bearing mice determined by use of positron emission tomography

  N Oku; Y Tokudome; H Tsukada; Y Namba; S Okada

  23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS CONTROLLED RELEASE SOCIETY 93 - 94 1022-0178 1996 [Refereed]
  
• Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties.

  C Koike; N Oku; M Watanabe; H Tsukada; T Kakiuchi; T Irimura; S Okada

  Biochimica et biophysica acta 1238 (2) 99 - 106 0006-3002 1995/09
• Cell-nuclear accumulation of stress protein (Hsp72) induced by dimethylarsenics

  K. Kato; K. Yamanaka; A. Hasegawa; M. Nakano; N. Oku; S. Okada

  Japanese Journal of Toxicology and Environmental Health Pharmaceutical Society of Japan 41 (1) P48  0013-273X 1995 [Refereed]
  
• Mode of gene damage induced by exposure to UVB and some radical species

  T. Sato; E. Iida; K. Kawaguchi; K. Yamanaka; T. Mori; N. Oku; S. Okada

  Japanese Journal of Toxicology and Environmental Health Pharmaceutical Society of Japan 41 (1) P17  0013-273X 1995 [Refereed]
  
• Tyrosine phosphorylation of βcatenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells

  Sayumi Shibamoto; Makio Hayakawa; Kenji Takeuchi; Takamitsu Hori; Naoto Oku; Keiji Miyazawa; Naomi Kitanfura; Masatoshi Takeichi; Fumiaki Ito

  Cell Communication and Adhesion Informa Healthcare 1 (4) 295 - 305 1541-9061 1994 [Refereed]
  
• Interaction between dimethylarsenics and active oxygen species in the induction of gene damage

  K. Kawaguchi; T. Sato; K. Yamanaka; N. Oku; S. Okada

  Japanese Journal of Toxicology and Environmental Health Pharmaceutical Society of Japan 40 (1) P24  0013-273X 1994 [Refereed]
  
• ENHANCEMENT OF CELL-MEMBRANE AFFINITY AND BIOLOGICAL-ACTIVITY OF POLYANIONIC POLYMERS

  Y SUDA; S KUSUMOTO; N OKU; RM OTTENBRITE

  POLYMERIC DRUGS AND DRUG ADMINISTRATION AMER CHEMICAL SOC 545 149 - 162 0097-6156 1994 [Refereed]
  
• Tumor imaging with technetium-99m-DTPA encapsulated in RES-avoiding liposomes

  Naoto Oku; Yukihiro Namba; Atsushi Takeda; Shoji Okada

  Nuclear Medicine and Biology 20 (4) 407 - 412 0969-8051 1993 [Refereed]
  
• MODIFIED POLYANIONIC POLYMERS FOR ENHANCED CELL-MEMBRANE INTERACTION

  Y SUDA; S KUSUMOTO; N OKU; H YAMAMOTO; M SUMI; F ITO; RM OTTENBRITE

  JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS SAGE PUBLICATIONS LTD 7 (3) 275 - 287 0883-9115 1992/07 [Refereed]
  
• Tumor accumulation of novel RES-avoiding liposomes

  Naoto Oku; Yukihiro Namba; Shoji Okada

  Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1126 (3) 255 - 260 0005-2760 1992/06 [Refereed]
  
• PREPARATION OF RES-AVOIDING LIPOSOMES

  N OKU; A TAKEDA; T TOYOTA; Y NAMBA; T SAKAKIBARA; F ITO; S OKADA

  JOURNAL OF PHARMACOBIO-DYNAMICS PHARMACEUTICAL SOC JAPAN 15 (6) S69 - S69 0386-846X 1992/06 [Refereed]
  
• Electron microscopic study on the interaction of Sendai virus with liposomes containing glycophorin

  Naoto Oku; Keizo Inoue; Shoshichi Nojima; Takashi Sekiya; Yoshinori Nozawa

  BBA - Biomembranes 691 (1) 91 - 96 0005-2736 1982/09 [Refereed]
  
• Studies on the interaction of sendai virus with liposomal membranes Sendai virus-induced agglutination of liposomes containing glycophorin

  Naoto Oku; Shoshichi Nojima; Keizo Inoue

  BBA - Biomembranes 646 (1) 36 - 42 0005-2736 1981/08 [Refereed]
  

Books etc

• Shimizu K, Oku N: "Liposomes conjugated with a pilot molecule." pp. 187-216.

  “Cancer drug delivery systems based on the tumor microenvironment.” (Matsumura Y, Tarin D. eds.) Springer Japan. 2019
• Koide H, Asai T, Shimizu K, Oku N: "Drug carrier systems for anticancer agents." pp. 153-169.

  “Polymeric Biomaterials: Medical and Pharmaceutical Applications, Volume 2” (Dumitriu S, Popa V. Eds.) CRC Press, Taylor and Francis Group, Boca Raton, FL. 2013
• Shimizu K, Oku N: "Brain tumor diagnosis using PET with angiogenic vessel-targeting liposomes." pp. 169-176.

  “Tumor of the central nervous system, Volume 3” (Hayat MA. ed.) Springer, New York, NY. 2011
• Asai T, Oku N: "Angiogenic vessel-targeting DDS by liposomalized oligapeptides." pp.335-347.

  “Liposomes Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers” (Weissig V. ed.) Methods in Molecular Biology 605, Humana Press, Totowa, NJ 2010
• Oku N, Ishii T: "Antiangiogenic Photodynamic Therapy with Targeted Liposomes." pp. 313-330.

  “Liposomes, Part G” (Düzgüneș N. ed.) Methods in Enzymology 465, Elsevier Academic Press, San Diego CA. 2009
• Shimizu K, Akizawa T, Asai T, Oku N: "Anti-angiogenic effect of green tea catechin through inhibition of membrane-type I matrix metalloproteinase, MTI-MMP." pp. 41-50.

  “Beneficial Health Effects of Green Tea” (Isemura M. ed.) Research Signpost, Kerala, India. 2008
• Yonezawa S, Asai T, Oku N: "Dorsal air sac model." pp. 229-238.

  “Angiogenesis Assays” (Staton CA, Lewis C, Bicknell R. eds.) John Wiley & Sons, Ltd. West Sussex, England 2006
• Oku N; Asai T: "Imaging cell trafficking." pp.349-364.

  “Molecular Imaging of the Lungs” (Schuster DP, Blackwell TS. eds.) Taylor and Francis Group, Boca Raton, FL 2005
• Oku N; Namba Y: "Glucuronate-modified, long-circulating liposomes for the delivery of anticancer agents." 145-162.

  “Liposomes, Part E” (Düzgüneș N. ed.) Methods in Enzymology 391, Elsevier Academic Press, San Diego, CA 2005
• Taki T; Oku N ”Inhibition of tumor metastasis by liposomes containing glyco-replica peptides.” pp.219-231

  “Liposome Methods and Protocols” (Basu SC, Basu M. eds.) Method in Molecular Biology 199, Humana Press, Totowa, NJ 2002
• Oku N: Chapter 18 "Tumor imaging with long circulating liposomes." pp. 257-266.

  "Long Circulating Liposomes: Old Drugs, New Therapeutics." (Woodle MC, Storm G. eds.) Springer-Verlag, Berlin 1998
• Liao J, Oku N, Suda Y, Ottenbrite RM: Chapter 8 "Hydrophobic modification of poly (MA-CDA) to enhance biological activity." pp. 247-265.

  "Functional Monomers and Polymeric Materials" (Takemoto K, Ottenbrite RM, Kamachi M. eds.) Marcel Dekker Inc. New York, NY 1997
• Oku N, Ottenbrite RM, Suda Y: Chapter 14, "Hydrophobization of polyanionic polymers to achieve higher biological activity." pp. 179-188.

  "Handbook of Engineering Polymeric Materials" (Cheremisinoff, NP. ed.) Marcel Dekker, Inc. New York, NY 1997
• リポソームの作成と実験法 (科学と生物実験ライン27）

  奥 直人 広川書店 1994
• Suda Y; Kusumoto, S; Oku N: "Enhancement of cell membrane affinity and biological activity of polyanionic polymers." pp.149-162

  "Polymeric Drugs and Drug Administration" (Ottenbrite RM. ed.) ACS Symposium Series 545, American Chemical Society. 1994
• Oku N, Koike C, Sugawra M, Tsukada H, Irimura T, Okada S: "Imaging of metastatic tumor cell trafficking." pp. 79-81

  Oku N, Koike C, Sugawra M, Tsukada H, Irimura T, Okada S: "Imaging of metastatic tumor cell trafficking." pp. 79-81 "Clinical PET in Oncology" (Matsuzawa T. ed.) World Scientific Publishing Co. 1994
• Tsujimoto M; Oku N: Chap. 7. "Regulations of TNF receptors." pp. 149-160.

  "Tumor Necrosis Factors: Structure, Function, and Mechanisms of Action" (Aggarwal BB, Vilcek J. eds.) Immunology Series 56, Marcel Dekker, Inc. NY. 1991
• Oku N: Chap. 3. "Liposomes." pp. 24-33.

  ”Polymeric Drugs and Drug Delivery Systems" (Dunn RL, Ottenbrite RM. eds.) ACS Symposium Series 469, American Chemical Society ACS Symposium Series 1991
• MacDonald RC; Oku N; MacDonald RI "Liposome formation re-visited." pp. 63-72

  "Liposome Letters" (Bangham AD. ed.) Academic Press, Inc. London 1983

MISC

• Design of multi-functionalized liposomes for adsorbing and neutralizing target molecules in vivo

  Satoshi Hirano; Hiroyuki Koide; Takahumi Ide; Yoshitaka Hamashima; Naoto Oku; Tomohiro Asai  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  258-  2019/08
• Development of a plastic antibody that captures vascular endothelial growth factor (VEGF) for anticancer therapy

  Hiroyuki Koide; Yu Hoshino; Yuri Nishimura; Yoshiko Miura; Naoto Oku; Kenneth Shea; Tomohiro Asai  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  258-  2019/08
• Development of polymer nanoparticles adsorbing alpha-glucosidase for diabetes treatment

  Ayaka Masuda; Hiroyuki Koide; Hiromichi Egami; Yoshitaka Hamashima; Naoto Oku; Tomohiro Asai  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  258-  2019/08
• Advantages of antibody usage in liposomal DDS for cancer chemotherapy

  清水広介; 奥直人  Drug Delivery System  34-  (1)  22‐28  2019/01
• Tissue factor標的化リポソームを用いたがんマルチターゲティング

  森 智哉; 大塚 和摩; 竹内 祥人; 成田 雄大; 清水 広介; 松村 保広; 奥 直人  日本薬学会年会要旨集  138年会-  (4)  74  -74  2018/03
• Usefulness of Liposomal Neuroprotectants for the Treatment of Ischemic Stroke

  福田 達也; 浅井 知浩; 奥 直人  オレオサイエンス  17-  (8)  359  -366  2017/08
• Tissue factorを標的としたがんマルチターゲティングDDS製剤の開発

  大塚 和摩; 竹内 祥人; 成田 雄大; 清水 広介; 松村 保広; 奥 直人  日本薬学会年会要旨集  137年会-  (4)  89  -89  2017/03
• ノビレチンの大量合成法確立とケミカルバイオロジー研究への展開

  稲井誠; 浅川倫宏; 浅川倫宏; 清水広介; 清水広介; 奥直人; 砂川陽一; 森本達也; 菅敏幸  創薬懇話会講演要旨集  2017-  2017
• ノビレチンの大量合成法確立とケミカルバイオロジー研究への展開

  菅敏幸; 浅川倫宏; 浅川倫宏; 稲井誠; 清水広介; 清水広介; 奥直人; 砂川陽一; 森本達也  メディシナルケミストリーシンポジウム講演要旨集  35th-  2017
• Chemical biological study of Nobiletin

  浅川倫宏; 浅川倫宏; 稲井誠; 清水広介; 清水広介; 奥直人; 砂川陽一; 森本達也; 菅敏幸  天然有機化合物討論会講演要旨集(Web)  59th-  2017
• ノビレチンのAβ分解酵素発現上昇作用における作用機序解析

  木村純子; 嘉島康二; 丸山浩司; 横須賀章人; 三巻祥浩; 奥直人; 大泉康; 大泉康; 大泉康  応用薬理  92-  (5-6)  2017
• Lipid Nanoparticle-mediated Delivery of Small Interfering RNA for Cancer Therapy

  浅井 知浩; 出羽 毅久; 奥 直人  オレオサイエンス  16-  (6)  271  -278  2016/06
• がんマルチターゲティングDDSに向けた抗TF抗体修飾リポソームの開発

  清水 広介; 竹内 祥人; 大塚 和摩; 成田 雄大; 松村 保広; 奥 直人  JSMI Report  9-  (2)  164  -164  2016/04
• Tissue factor標的リポソームによるがんマルチターゲティングDDS製剤の開発

  大塚 和摩; 竹内 祥人; 成田 雄大; 清水 広介; 松村 保広; 奥 直人  日本薬学会年会要旨集  136年会-  (4)  68  -68  2016/03
• ノビレチンの抗認知症効果の分子メカニズム-病態モデル神経細胞を用いたAβ分解促進作用の解析-

  木村純子; 清水広介; 嘉島康二; 横須賀章人; 三巻祥浩; 奥直人; 大泉康; 大泉康; 大泉康  応用薬理  90-  (5-6)  2016
• がんマルチターゲィテングDDSを目指した抗TF抗体修飾リポソームの開発

  清水 広介; 竹内 祥人; 成田 雄大; 松村 保広; 奥 直人  日本薬剤学会年会講演要旨集  30年会-  123  -123  2015/05
• ヒトiPS細胞由来神経細胞におけるノビレチンの記憶形成関連遺伝子発現亢進作用の解析

  木村純子; 清水広介; 嘉島康二; 横須賀章人; 三巻祥浩; 奥直人; 大泉康; 大泉康  応用薬理  89-  (1-2)  2015
• A Novel Therapy for Giant-cell Myocarditis with Nanotechnology

  Keiji Okuda; Hai Ying Fu; Shota Tsuchida; Takashi Matsuzaki; Tomohiro Asai; Naoto Oku; Haruo Hanawa; Masafumi Kitakaze; Yasushi Sakata; Tetsuo Minamino  JOURNAL OF CARDIAC FAILURE  20-  (10)  S144  -S145  2014/10
• Synthetic polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF)

  Hiroyuki Koide; Yu Hoshino; Yuri Nishimura; Yoshiko Miura; Naoto Oku; Kenneth J. Shea  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  248-  2014/08
• Development of anti-high mobility group box-1 synthetic polymer nanoparticles for the treatment of cerebral ischemia-reperfusion injury

  Tatsuya Fukuta; Hiroyuki Koide; Yu Hoshino; Yoshiko Miura; Kenneth J. Shea; Naoto Oku  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  248-  2014/08
• カテキンプローブの合成と分子イメージング 緑茶の有効成分カテキンを光らせる

  菅敏幸; 浅川倫宏; 奥直人; 清水広介; 山田静雄; 原田典弘; 塚田秀夫  化学  69-  (3)  38  -42  2014/03
• 柑橘類果皮含有抗認知症成分ノビレチンの記憶障害改善作用メカニズムの解析

  木村純子; 清水広介; 根本清光; 出川雅邦; 横須賀章人; 三巻祥浩; 奥直人; 大泉康; 大泉康  応用薬理  87-  (1-2)  2014
• RNA干渉効率の向上を目指した抗体修飾脂質ナノ粒子の開発

  岡田憲明; 岡本彩香; 清水広介; 浅井知浩; 南野哲男; 目加田英輔; 奥直人  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集  24th-2014-  2014
• カテキンプローブの効率的合成と分子イメージングによる動態解析

  菅敏幸; 浅川倫宏; 奥直人; 清水広介; 塚田秀夫  Chem Times  2014-  (1)  18  -23  2014/01
• Development of Novel Therapy for Autoimmune Myocarditis with Nanotechnology

  Haiying Fu; Keiji Okuda; Shota Tsuchida; Takashi Matsuzaki; Tomohiro Asai; Naoto Oku; Haruo Hanawa; Issei Komuro; Masafumi Kitakaze; Tetsuo Minamino  JOURNAL OF CARDIAC FAILURE  19-  (10)  S131  -S131  2013/10
• アミロイドβ投与による視床下部-下垂体-副腎皮質系の機能亢進と周辺症状様行動.

  Ide K; Tamano H; Ando M; Oku N; Takeda A  日本薬学会 第133年会.  2013/03
• ノビレチンの脳梗塞障害治療効果

  奥 直人; 安田 和; 石井 貴之; 尾山 大; 福田 達也; 上戸 由里佳; 浅井 知浩; 清水 広介; 菅 敏幸; 山田 静雄; 大泉 康  応用薬理  84-  (1)  34  -34  2013/02
• Social isolation-induced aggressive behavior of zinc-deficient mice and effect of yokukansan.

  Ide K; Iwaki H; Tamano H; Oku N; Takeda A  ICPF2012  2012/11
• Isolation-induced aggressive behavior and object recognition memory of amyloid β protein-injected mice.

  Ide K; Takada S; Tamano H; Oku N; Takeda A  35th Annual Meeting of Japan Neuroscience Society.  2012/11
• アミロイドβタンパク質の脳室内等よによる認知症周辺症状モデルの確立.

  Ide K; Takada S; Tamano H; Oku N; Takeda A  フォーラム2012: 衛生薬学・環境トキシコロジー.  2012/10
• グルタミン酸神経系の調節を介した抑肝散の攻撃行動抑制効果.

  Ide K; Iwaki H; Tamano H; Oku N; Takeda A  第58回 日本薬学会東海支部 総会・大会.  2012/07
• 亜鉛不足による隔離飼育マウスの攻撃性増大メカニズムと抑肝散の効果.

  Ide K; Iwaki H; Tamano H; Takeda A; Oku N  フォーラム2011: 衛生薬学・環境トキシコロジー  2011/10
• 前立腺がんを標的としたレクチン修飾リポソームの開発

  清水広介; 大橋健人; 奥直人  杉山産業化学研究所年報  2010-  57  -69  2011/04
• Luminescence-fluorescence in vivo imaging system

  ASAI Tomohiro; OKU Naoto  Drug delivery system  26-  (2)  141  -143  2011/03
• Design of polymer nanoparticles that are capable of neutralizing toxicity of fetal proteins

  Yu Hoshino; Hiroyuki Koide; Dai Oyama; Yusuke Yonamine; Shih-Hui Lee; Naoto Oku; Kenneth J. Shea  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  241-  2011/03
• Depression-like behavior and object recognition memory in zinc deficiency; involvement of glucocorticoid

  Haruna Tamano; Taisuke Ogawa; Shunsuke Takada; Masaki Ando; Naoto Oku; Tomomi Hagiwara; Mitsugu Watanabe; Atsushi Takeda  NEUROSCIENCE RESEARCH  71-  E368  -E368  2011
• Impairment of learning and memory by transient reduction of synaptic zinc in the hippocampus

  Shunsuke Takada; Atsushi Takeda; Masatoshi Nakamura; Masaki Ando; Naoto Oku  NEUROSCIENCE RESEARCH  71-  E277  -E277  2011
• Enhancement of seizure susceptibility of Noda epileptic rat (NER) by zinc chelators

  Masashi Iida; Atsushi Takeda; Masaki Ando; Syunsuke Takada; Masatoshi Nakamura; Naoto Oku  NEUROSCIENCE RESEARCH  71-  E295  -E295  2011
• ナノマテリアルの健康影響評価手法の総合的開発および体内動態を含む基礎的有害性情報の集積に関する研究 ナノマテリアルによる細胞内酸化ストレス評価法の開発に関する研究

  奥直人; 清水広介  ナノマテリアルの健康影響評価手法の総合的開発および体内動態を含む基礎的有害性情報の集積に関する研究 平成22年度 総括・分担研究報告書  62  -68  2011
• Recognition and neutralization of a toxic peptide in vivo by polymer nanoparticles

  Yu Hoshino; Hiroyuki Koide; Takeo Urakami; Hiroaki Kanazawa; Takashi Kodama; Naoto Oku; Shea J. Kenneth  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  239-  2010/03
• Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components

  Miki Suzuki; Haruna Tamano; Masaki Ando; Atsushi Takeda; Naoto Oku  NEUROSCIENCE RESEARCH  68-  E338  -E338  2010
• Attenuation of forskolin-induced mossy fiber long-term potentiation by zinc

  Masaki Ando; Atsushi Takeda; Shingo Kanno; Naomi Sakurada; Naoto Oku  NEUROSCIENCE RESEARCH  68-  E338  -E338  2010
• Differential action of zinc in hippocampal CA1 long-term potentiation between 3-week-old and 6-week-old rats

  Kosuke Itagaki; Atsushi Takeda; Masaki Ando; Naoto Oku  NEUROSCIENCE RESEARCH  68-  E339  -E339  2010
• ANGIOGENIC VESSEL-TARGETED LIPOSOMES FOR IN VIVO DELIVERY OF SIRNA

  Tomohiro Asai; Naoto Oku  JOURNAL OF GENE MEDICINE  11-  (12)  1149  -1149  2009/12
• COLL 273-Design of polymer nanoparticles to capture and neutralize the toxic peptide melittin

  Yu Hoshino; Hiroyuki Koide; Takashi Kodama; Takeo Urakami; Naoto Oku; Yoshio Okahata; Kenneth J. Shea  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  238-  2009/08
• siRNA体内動態のPET解析と新規ベクターの開発

  浅井 知浩; 奥 直人  Drug delivery system  24-  (3)  258  -258  2009/06
• HB‐EGF標的化リポソームによる新規ターゲティングDDSの開発

  重松宏和; 浅井知浩; 南野哲男; 朝野仁裕; 高島成二; 目加田英輔; 奥直人  Drug Delivery System  24-  (3)  316  2009/06
• Bladder selectivity of novel anticholinergic agents based on in vivo drug-receptor binding characteristics

  Shizuo Yamada; Shuji Maruyama; Hideo Tsukada; Naoto Oku; Yoshihiko Ito  JOURNAL OF PHARMACOLOGICAL SCIENCES  109-  35P  -35P  2009
• Tissue distribution of fullerene C60 in rat after oral and tail-vein administration by LC-MS/MS

  Reiji Kubota; Maiko Tahara; Klmik Shimizu; Akihiko Hirose; Kosuke Shimizu; Naoto Oku; Tetsuji Nishimura  TOXICOLOGY LETTERS  180-  S223  -S223  2008/10
• Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc

  Atsushi Takeda; Masaki Ando; Shingo Kanno; Naomi Sakurada; Naoto Oku  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN  128-  26  -26  2008
• Cancer gene therapy with mitochondria-targeting p53 gene

  Takuya Umemoto; Koji Hirashima; Tomohiro Asai; Motohiro Mihara; Shin-ichi Miyagawa; Naoto Oku  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN  128-  101  -102  2008
• Development of a novel immune disease therapy by reverse targeting DDS

  Sho Ikai; Haruna Miyauchi; Tomohiro Asai; Naoto Oku  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN  128-  105  -106  2008
• IN VIVO ANALYSIS OF BRAIN MUSCARINIC RECEPTOR OCCUPANCY AFTER ORAL OXYBUTYNIN IN CONSCIOUS RHESUS MONKEY BY USING POSITRON EMISSION TOMOGRAPHY (PET)

  Shuji Maruyama; Hideo Tsukada; Shingo Nishiyama; Takeharu Kakiuchi; Dai Fukumoto; Naoto Oku; Shizuo Yamada  DRUG METABOLISM REVIEWS  40-  179  -179  2008
• 腫瘍新生血管標的化リポソーム (特集 抗がん剤のDrug Delivery System)

  浅井 知浩; 米澤 正; 奥 直人  Mebio oncology  4-  (2)  48  -57  2007/06
• In Vitro Efficacy of a Sterically Stabilized Immunoliposomes Targeted to Membrane Type 1 Matrix Metalloproteinase (MT1-MMP)(Biopharmacy)

  ATOBE Kazutaka; ISHIDA Tatsuhiro; ISHIDA Emi; HASHIMOTO Kouichi; KOBAYASHI Hideo; YASUDA Jyunko; AOKI Takanori; OBATA Ken-ichi; KIKUCHI Hiroshi; AKITA Hidetaka; ASAI Tomohiro; HARASHIMA Hideyoshi; OKU Naoto; KIWADA Hiroshi  Biological & pharmaceutical bulletin  30-  (5)  972  -978  2007/05
• 新戦略Reverse Targeting DDSを用いた新規免疫疾患治療法の開発

  宮内春奈; 市川香苗; 浦上武雄; 米澤正; 清水広介; 浅井知浩; 奥直人  日本薬学会年会要旨集  127th-  (3)  2007
• 標的化ポリカチオンリポソームによるsiRNAの導入:がん治療を目的として

  米澤正; 鈴木佑子; 浅井知浩; 石田竜弘; 際田弘志; 出羽毅久; 南後守; 奥直人  日本薬学会年会要旨集  127th-  (1)  2007
• Novel engineering technology to formulate siRNA medicine

  Atsushi Tsuruta; Eriya Kenjo; Tomohiro Asai; Noriyuki Maeda; Naoto Oku  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN  127-  173  -174  2007
• Unique response of extracelluar zinc in the ventral hippocampus against novelty stress

  Atsushi Takeda; Shingo Kannno; Masaki Ando; Naomi Sakurada; Akira Minami; Naoto Oku  NEUROSCIENCE RESEARCH  58-  S164  -S164  2007
• Functional analysis of junctional adhesion molecule-C (JAM-C) in cancer metastasis

  Yuuki Ishida; Chiaki Fuse; Tomoya Hikita; Kosuke Shimizu; Tomohiro Asai; Naoto Oku  CLINICAL & EXPERIMENTAL METASTASIS  24-  (4)  255  -255  2007
• 0312 胃癌腹膜播種に対する化学療法とBiopanningを用いた標的化(胃診断6(腹膜播種),一般演題,第61回日本消化器外科学会定期学術総会)

  秋田 倫幸; 丸田 福門; 石曽根 聡; 久保 直樹; 浅井 知浩; 奥 直人; 中山 淳; 宮川 眞一  日本消化器外科学会雑誌  39-  (7)  1075  -1075  2006/07
• Zinc action in hippocampal mossy fiber long-term potentiation

  SAKURADA Naomi; TAKEDA Atsushi; FUKE Sayuri; MINAMI Akira; OKU Naoto  Biomedical research on trace elements  17-  (2)  179  -179  2006/07
• Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortex

  IMANO Sachie; TAKEDA Atsushi; ITOH Hiromasa; OKU Naoto  Biomedical research on trace elements  17-  (2)  180  -180  2006/07
• 光増感剤封入ポリカチオンリポソームを用いた新生血管標的光線力学療法

  竹内良人; 黒羽子孝太; 市川香苗; 米沢正; 南後守; 奥直人  日本薬学会年会要旨集  123rd-  (4)  2003
• 光増感剤封入ポリカチオンリポソームを用いた新生血管標的がん光線力学療法

  竹内良人; 黒羽子孝太; 市川香苗; 米沢正; 南後守; 奥直人  日本癌学会総会記事  62nd-  2003
• がん光線力学療法とその細胞死機構の解析

  米沢正; 市川香苗; 疋田智也; 竹内良人; 黒羽子孝太; 難波幸弘; 今井浩孝; 中川靖一; 奥直人  生体膜と薬物の相互作用シンポジウム講演要旨集  25th-  2003
• Topical application of liposomal linoleic acid: Enhancement of long-lasting effect in the epidermis

  Y Shigeta; H Imanaka; H Ando; T Makino; K Kurohane; N Oku; N Baba  JOURNAL OF LIPOSOME RESEARCH  13-  (1)  85  -85  2003
• Intensive tumor suppression by anti-angiogenic photodynamic therapy with polycation-modified liposomal photosensitizer

  Y Takeuchi; K Kurohane; North, JR; Y Namba; M Nango; N Oku  JOURNAL OF LIPOSOME RESEARCH  13-  (1)  88  -88  2003
• Establishment of anti-neovascular therapy by using novel liposomal formulation modified with MT1-MMP-targeted peptides

  A Kondo; T Asai; K Ogino; T Taki; H Tsukada; K Baba; N Oku  JOURNAL OF LIPOSOME RESEARCH  13-  (1)  72  -72  2003
• Cancer therapy by liposomal TAS-103, a novel anti-tumor agent

  M Takada; K Shimizu; K Kuromi; T Asai; K Baba; N Oku  JOURNAL OF LIPOSOME RESEARCH  13-  (1)  87  -87  2003
• Liposomalization of TOP-53

  K Shimizu; T Asai; M Takada; K Baba; Y Namba; N Oku  JOURNAL OF LIPOSOME RESEARCH  13-  (1)  85  -86  2003
• Inhibitory Effect of Green Tea Polyphenols on Membrane-Type 1 Matrix Metalloproteinase, MT1-MMP.

  Oku, N; Matsukawa, M; Yamakawa, S; Asai, T; Yahara, S; Hashimoto, F; Akizawa, T  Biol. Pharm. Bull.  26-  (9)  1235  -1238  2003  [Refereed]
  
• Cancer Chemotherapy by liposomal 6-[[2-(Dimethylamion)ethyl]-3-hydroxy-7H-indeno[2, 1-c]quinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. [共著]

  Biol. Pharm. Bull.  25, 1385-1387-  2002
• Molecular assembly of Zinc-Nickel hybrid porphyrin dimer using synthetic 4a-Helix polypeptides. [共著]

  Chem. Lett.  2002, 848-849-  2002
• A new bioassay of environmental chemicals based on their effects on tumor cell invasion. [共著]

  J. Health Sci.  48, 310-316-  2002
• Stress response caused by chronic alcohol intake in aged rat brain. [共著]

  Clin. Exp. Res.  26, 1017-1023-  2002
• Relationship between zinc and neurotransmitters released into the amygdalar extracellular space. [共著]

  Brain Research.  936, 91-94-  2002
• Isolation of novel peptide homing to tumor-derived neovasculature that suppresses tumor growth. [共著]

  Biol. Pharm. Bull.  25-  (7)  904  -906  2002
• ･Hydrophobic modification of poly (MA-CDA) to enhance biological activity. [共著]

  J. Macromol. Sci. Polym. Rev.  C42, 291-306-  2002
• Anti-neovascular therapy by liposomal DPP-CNDAC targeted to angiogenic vessels. [共著]

  FEBS Lett.  520, 167-170-  2002
• Potential usage of liposomal ab- aminoalky1-4'-O-demethy1-4- desoxypodophyllotoxin (TOP-53) for cancer chemotherapy. [共著]

  Biol. Pharm. Bull.  25-  (6)  783  -786  2002
• Anti-neovasular therapy using novel peptides homing to angiogenic vessels. [共著]

  Oncogene.  21, 2662-2669-  2002
• Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels. [共著]

  FEBS Lett.  510, 206-210-  2002
• Abnormal iron delivery to born marrow in neonatal hypotransferrinemic mice. [共著]

  BioMetals  15, 33-36-  2002
• A new bioassay of environmental chemicals based on their effects on tumor cell invasion.

  J. Health Sci.  48, 310-316-  2002
• Cancer Chemotherapy by liposomal 6-[[2-(Dimethylamion)ethyl]-3-hydroxy-7H-indeno[2, 1-c]quinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. [共著]

  Biol. Pharm. Bull.  25, 1385-1387-  2002
• Molecular assembly of Zinc-Nickel hybrid porphyrin dimer using synthetic 4a-Helix polypeptides. [共著]

  Chem. Lett.  2002, 848-849-  2002
• A new bioassay of environmental chemicals based on their effects on tumor cell invasion. [共著]

  J. Health Sci.  48, 310-316-  2002
• Stress response caused by chronic alcohol intake in aged rat brain. [共著]

  Clin. Exp. Res.  26, 1017-1023-  2002
• Relationship between zinc and neurotransmitters released into the amygdalar extracellular space. [共著]

  Brain Research.  936, 91-94-  2002
• Isolation of novel peptide homing to tumor-derived neovasculature that suppresses tumor growth. [共著]

  Tomohiro Asai; Hideto Fukatsu; Koichi Kuromi; Koichi Ogino; Michinori Tanaka; Naoto Oku; Takao Taki  Biol. Pharm. Bull.  25-  (7)  904  -906  2002
• ･Hydrophobic modification of poly (MA-CDA) to enhance biological activity. [共著]

  J. Macromol. Sci. Polym. Rev.  C42, 291-306-  2002
• Anti-neovascular therapy by liposomal DPP-CNDAC targeted to angiogenic vessels. [共著]

  FEBS Lett.  520, 167-170-  2002
• Potential usage of liposomal ab- aminoalky1-4'-O-demethy1-4- desoxypodophyllotoxin (TOP-53) for cancer chemotherapy. [共著]

  Kosuke Shimizu; Miki Takada; Tomohiro Asai; Kenji Irimura; Kazuhiko Baba; Naoto Oku  Biol. Pharm. Bull.  25-  (6)  783  -786  2002
• Anti-neovasular therapy using novel peptides homing to angiogenic vessels. [共著]

  Oncogene.  21, 2662-2669-  2002
• Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels. [共著]

  FEBS Lett.  510, 206-210-  2002
• Abnormal iron delivery to born marrow in neonatal hypotransferrinemic mice. [共著]

  BioMetals  15, 33-36-  2002
• Physiological Function of Zinc in Synapses

  MINAMI Akira; TAKEDA Atsushi; OKU Naoto  Biomedical research on trace elements  12-  (4)  263  -264  2001/12
• Metabolic fate of (-)-[4-H-3]epigallocatechin gallate in rats after oral administration

  T Kohri; N Matsumoto; M Yamakawa; M Suzuki; F Nanjo; Y Hara; N Oku  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY  49-  (8)  4102  -4112  2001/08
• Photodynamic therapy targeted to tumor-induced angiogenic vessels

  K Kurohane; A Tominaga; K Sato; North, JR; Y Namba; N Oku  CANCER LETTERS  167-  (1)  49  -56  2001/06
• Anti-angiogenic effect of EGCG through inhibition of matrix metalloproteinases. [共著]

  Proceedings of 2001 International Conference on O-CHA(tea) Culture and Science Ⅲ.  130-133-  2001
• Effect of green tea catechin on learning and memory in senescence-accelerated mice. [共著]

  Proceedings of 2001 International Conference on O-CHA(tea) Culture and Science Ⅲ.  170-172-  2001
• Abnormal iron accumulation in the brain of neonatal hypotransferrinemic mice. [共著]

  Brain Res.  912, 154-161-  2001
• A novel non-viral gene transfer system, polycation liposomes. [共著]

  Adv, Drug Delivry  52, 209-218-  2001
• Determination of pyrimethamine in animal tissue and egg by liquid chromatography with fluorescence detection. [共著]

  J. AOAC Int.  84, 1031-1034-  2001
• Antitumor effect of photodynamic therapy targeted to tumor-induced angiogenic vessels. [共著]

  Progress in Drug Delivery System X.  53-62-  2001
• Zinc-65 imaging of rat brain tumors. [共著]

  Cancer Res.  61, 5065-5069-  2001
• 腫瘍新生血管を標的とした光線力学的療法によるがん治療。[共著]

  Progress in Drug Delivery System X.  53-62-  2001
• がん光線力学的療法〔共著〕

  化学と薬学の教室  141-  17  -19  2001
• 癌転移初期過程のPET解析

  8-  71  -79  2001
• Anti-angiogenic effect of EGCG through inhibition of matrix metalloproteinases. [共著]

  Proceedings of 2001 International Conference on O-CHA(tea) Culture and Science Ⅲ.  130-133-  2001
• Effect of green tea catechin on learning and memory in senescence-accelerated mice. [共著]

  Proceedings of 2001 International Conference on O-CHA(tea) Culture and Science Ⅲ.  170-172-  2001
• Abnormal iron accumulation in the brain of neonatal hypotransferrinemic mice. [共著]

  Brain Res.  912, 154-161-  2001
• A novel non-viral gene transfer system, polycation liposomes. [共著]

  Adv, Drug Delivry  52, 209-218-  2001
• Determination of pyrimethamine in animal tissue and egg by liquid chromatography with fluorescence detection. [共著]

  J. AOAC Int.  84, 1031-1034-  2001
• Antitumor effect of photodynamic therapy targeted to tumor-induced angiogenic vessels. [共著]

  Progress in Drug Delivery System X.  53-62-  2001
• Zinc-65 imaging of rat brain tumors. [共著]

  Cancer Res.  61, 5065-5069-  2001
• Overexpression of the Csk homologous kinase(Chk tyrosine kinase)induces multinucleation : A possible role for chromosome-associated Chk in chromosome dynamics.〔共著〕

  J. Cell Sci.  114-  1631  -1641  2001
• Zinc homeostasis in the brain of adult rats fed zinc-deficient diet.〔共著〕

  J. Neurosci. Res.  63-  447  -452  2001
• Cadmium toxicity in synaptic neurotransmission in the brain.〔共著〕

  Brain Res.  894-  (2)  336  -339  2001
• Cancer Photodynamic Therapy

  141-  17  -19  2001
• PET analysis of early metastatic processes.

  Surgery Frontier  8-  71  -79  2001
• Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-B-D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.〔共著〕

  Cancer Lett  162-  49  -56  2001
• LEARNING AND BEHAVIOR UNDER ZINC DEFICIENCY

  TAKEDA A; HANAJIMA T; TAKEFUTA S; MINAMI A; OKU N  Biomedical research on trace elements  11-  (4)  397  -398  2000/12
• Evaluation of drug targeting strategies and liposomal trafficking

  N Oku; Y Tokudome; T Asai; H Tsukada  CURRENT PHARMACEUTICAL DESIGN  6-  (16)  1669  -1691  2000/11
• Polycation liposomes, a novel nonviral gene transfer system, constructed from cetylated polyethylenimine

  Y Yamazaki; M Nango; M Matsuura; Y Hasegawa; M Hasegawa; N Oku  GENE THERAPY  7-  (13)  1148  -1155  2000/07
• Potential usage of thermosensitive liposomes for site-specific delivery of cytokines

  Y Yuyama; M Tsujimoto; Y Fujimoto; N Oku  CANCER LETTERS  155-  (1)  71  -77  2000/07
• Possible role of immune surveillance at the initial phase of metastasis produced by B16BL6 melanoma cells

  H Kikkawa; H Imafuku; H Tsukuda; N Oku  FEBS LETTERS  467-  (2-3)  211  -216  2000/02
• 低分子ペプチドリガンドの簡単な探索法とDDSへの応用〔共著〕

  化学と薬学の教室  140-  15  -17  2000
• 新生血管を標的としたリポソーム製剤の開発〔共著〕

  9-  1  -11  2000
• 生体内分子標的化におけるペプチド工学・リポソーム工学の応用

  16-  (8)  64  -65  2000
• 臨界とは何か、なぜ臨界事故が起こったのか?

  化学と薬学の教室  137-  12  -14  2000
• ファージディスプレイペプチドライブラリー: 標的化のための低分子プローブの簡単な作成法。[共著]

  分析  2000-  (2)  99  -100  2000
• Simple selection of low molecular weight peptide ligands and their applications for DDS.

  140-  15  -17  2000
• Liposomal drug against tumor angiogenic vessels

  Progr. Drug Delivery Syst.  9-  1  -11  2000
• Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70(Hsc70)in aged rat brain.〔共著〕

  ┣DBJ.(/)-┫DB ┣DBGerontology.(/)-┫DB  55A-  B329-335  2000
• Application of peptide and liposome engineering on in vivo molecular targeting.

  Boundary  16-  (8)  64  -65  2000
• Manganese concentration in mouse brain after intravenous injection. [共著]

  J. Neurosci. Res.  61-  350  -356  2000
• What is the critical phase in nuclear reaction.

  137-  12  -14  2000
• Hepatic zinc response via metallothionein induction after tumor transplantation. [共著]

  Biochem. Biophys. Res Commun.  270-  (3)  1140  -1143  2000
• Relationship between brain zinc metabolism and transient learning impairment of adult rats fed zinc-deficient diet. [共著]

  Brain Res.  859-  352  -357  2000
• Influence of histidine on zinc transport into rat brain. [共著]

  J. Health Sci.  46-  (3)  209  -213  2000
• ⁶⁵Zn Iocalizaiton in rat brain after intracerebroventricular injection of ⁶⁵Zn-histidine. [共著]

  Brain Res.  863-  241  -244  2000
• Brain manganese and neural function. [共著]

  Metal Ions in Bioloby and Medicine  6-  440  -442  2000
• Tumor growth after subcutaneous injection is affected by hepatic zinc-metallotionein level. [共著]

  Metal Ions in Bioloby and Medicine  6-  218  -220  2000
• Iron accumulation in hypotransferrinemic mouse brain. [共著]

  Metal lons in Bioloby and Medicine  6-  123  -125  2000
• Rapid determination of nosiheptide in meat and egg by liquid chromatography with fluorescence detection. [共著]

  J. AOAC Int.  83-  17  -19  2000
• A simple technique to prepare small molecular probe for targeting.

  2000-  (2)  99  -100  2000
• Suppression of GD1 alpha ganglioside-mediated tumor metastasis by liposomalized WHW-peptide

  M Takikawa; H Kikkawa; T Asai; N Yamaguchi; D Ishikawa; M Tanaka; K Ogino; T Taki; N Oku  FEBS LETTERS  466-  (2-3)  381  -384  2000/01
• Magnetic resonance lymphography of profundus lymph nodes with liposomal gadolinium-diethylenetriamine pentaacetic Acid.

  Yoshiko FUJIMOTO; Yoshitaka OKUHATA; Shia TYNGI; Yukihiro NAMBA; Naoto OKU  Biol. Pharm. Bull.  23-  (1)  97  -100  2000
• POSSIBLE ROLE OF MANGANESE IN RAT OLFACTROY SYSTEM

  TAKEDA A; ISHIWATARI S; SOTOGAKU N; OKADA S; OKU N  Biomedical research on trace elements  10-  (3)  249  -250  1999/12
• ROLE OF ZINC ON SYNAPTIC NEUROTRANSMISSION

  TAKEDA A; TAKEFUTA S; TOCHIGI M; SAWASHITA J; HANAJIMA T; OKADA S; OKU N  Biomedical research on trace elements  10-  (3)  247  -248  1999/12
• MANGANESE ACCUMULATION IN THE BASAL GANGLIA IN MOUSE BRAIN

  SOTOGAKU N; TAKEDA A; ISHIWATARI S; OKADA S; OKU N  Biomedical research on trace elements  10-  (3)  215  -216  1999/12
• RELEASE OF ZINC FROM THE BRAIN OF El (EPILEPSY) MICE DURING SEIZURE INDUCTION

  TAKEDA A; HANAJIMA T; IJIRO H; OKADA S; OKU N  Biomedical research on trace elements  10-  (3)  149  -150  1999/12
• Anticancer therapy using glucuronate modified long-circulating liposomes

  N Oku  ADVANCED DRUG DELIVERY REVIEWS  40-  (1-2)  63  -73  1999/11
• (109)Cd transport in rat brain

  A Takeda; S Takefuta; H Ijiro; S Okada; N Oku  BRAIN RESEARCH BULLETIN  49-  (6)  453  -457  1999/08
• Delivery of contrast agents for positron emission tomography imaging by liposomes

  N Oku  ADVANCED DRUG DELIVERY REVIEWS  37-  (1-3)  53  -61  1999/05
• GD1 alpha-replica peptides functionally mimic GD1 alpha, an adhesion molecule of metastatic tumor cells, and suppress the tumor metastasis (vol 441, pg 20, 1999)

  D Ishikawa; H Kikkawa; K Ogino; Y Hirabayashi; N Oku; T Taki  FEBS LETTERS  444-  (2-3)  296  -296  1999/02
• PCL: 新規非ウイルス系遺伝子導入システム[共著]

  8-  41  -51  1999
• リポソーム化CNDACリン脂質誘導体による肺転移癌治療[共著]

  浅井 知浩; 黒羽子 孝太; 岡田 昌二; 周東 智; 粟野 博一; 松田 彰; 塚田 秀夫; 奥 直人  Drug Delivery System  14-  (2)  103  -108  1999
• 接着heterophilic(癌細胞と組織/血球)

  16-  (2)  16  -23  1999
• PCL : Novel non-viral gene transfer system.

  Progr. Drug Delivery Syst.  8-  41  -51  1999
• Application of surface-coated liposomes for oral delivery of peptide : Effects of coating the liposome's surface on the GI transit of insulin. [共著]

  J. Pharmaceut. Sci.  88-  (2)  248  -252  1999
• Release of zinc from the brain of El (epilepsy) mice during seazure induction. [共著]

  Brain Res.  828-  (1/2)  174  -178  1999
• Effect of Histidine on Zinc Transport into Brain

  TAKEDA A.; SUZUKI M.; KAWAI M.; OKU N.; OKADA S.  Biomedical research on trace elements  9-  (3)  131  -132  1998/12
• RELATIONSHIP BETWEEN ZINC METABOLISM IN RAT BRAIN AND LEARNING

  TAKEDA A; TAKEFUTA S; TOCHIGI M; SAWASHITA J; OKU N; OKADA S  Biomedical research on trace elements  9-  (3)  133  -134  1998/12
• Role of Transferrin in Manganese Transport into Rat Brain

  TAKEDA A; ISHIWATARI S; OKU N; OKADA S  Biomedical research on trace elements  9-  (3)  75  -76  1998/12
• Antitumor activity of 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-β-D-arabino-pentofuranosylcytosine is enhanced by long-circulationg liposomatlization.

  Tomohiro ASAI; Kohta KUROHANE; Satoshi SHUTO; Hirokazu AWANO; Akira MATSUDA; Hideo TSUKADA; Yukihiro NAMBA; Shoji OKADA; Naoto OKU  Bio Pharm. Bull  21-  (7)  766  -771  1998
• RGD構造類似体アルギニルアミノヘキサン酸およびその修飾リポソームによるがん転移抑制[共著]

  黒羽子 孝太; 奥 直人; 宮本 大誠; 鈴木 康夫; 岡田 昌二; 難波 幸弘  Drug Delivery System  13-  (6)  401  -406  1998
• CNDACリン脂質誘導体含有RES回避リポソームによる肺転移がん治療[共著]

  7-  19  -28  1998
• 生化学辞典 第3版

  東京化学同人  1998
• 機能性リポソームの臨床応用

  総合臨床  47-  2793  -2794  1998
• 転移性癌細胞の細胞交通[共著]

  実験医学  16-  2069  -2075  1998
• CNDACリン脂質誘導体含有RES回避リポソームの抗腫瘍効果[共著]

  13-  341  -346  1998
• PETで観察する細胞の動態

  放射線科学  41-  319  -327  1998
• 放射線教育入門テキスト.[共著]

  日本アイソトープ協会  1998
• Role of Sialylglycoconjugate(s) in the initial Phase of Metastasis of Liver-metastatic RAW117 Lymphoma Cells. [共著]

  Drug Development through Biopharmaceuticol Sciences. Proceedings.  89  -94  1998
• GD1α-replica Peptides Functionally Mimic GD1α, an adhesion molecule of metastatic tumor cells, and suppress the tumor metastasis. [共著]

  FEBS Lett.  441-  (1)  20  -24  1998
• Design of the Functionalized Liposomes Using the Molecules Having Saturted Isoprenoid Chains Derived from Archaebacterial Lipids. [共著]

  Recent Res. Devel. in Pure&Applied Chem.  2-  239  -245  1998
• β-Thujaplicin Zinc Chelate linduces Apoptosis in Mouse High Metastatic Melanoma Bl6 BL6 Cells. [共著]

  Daisei MIYAMOTO; Naoko ENDO; Naoto OKU; Yaeno ARIMA; Takashi SUZUKI; Yasuo SUZUKI  Biol. Pharm. Bull.  21-  (12)  1258  -1262  1998
• A New Interpretation of Salicylic Acid Transport across the Lipid Bilayer : Implications of pH-Dependent but not Carrier-Medicated Absorption from Gastrointestinal Tract. [共著]

  J. Pharmacol. Exp. Therapeut  285-  1175  -1180  1998
• Antitumor Activity of 5'-O-Dipalmitoylphosphatidyl2'-C-Cyano-2'-deoxy-1-β-D-arabiono-pentofuranosylcytosine Is Enhanced by Long-circulating Liposomalization. [共著]

  J. Pharmacol. Exp. Therapeut.  285-  1175  -1180  1998
• How Platelet Aggregation Affects B16BL6 Melanoma Cell Trafficking. [共著]

  FEBS Lett.  427-  (2)  286  -290  1998
• Tumor cells with organ-specific metastatic ability show distinctive trafficking in vivo: Analyses by positron emission tomography and bioimaging

  C Koike; M Watanabe; N Oku; H Tsukada; T Irimura; S Okada  CANCER RESEARCH  57-  (16)  3612  -3619  1997/08
• 医薬におけるリポソームの応用と皮膚への作用.[共著]

  奥 直人; 岩永 一範; 山下 伸二  日本化粧品技術者会誌  31-  (3)  254  -262  1997
• 鼻腔内局所作用を目的とした薬物のための経鼻投与製剤の設計.[共著]

  6-  33  -41  1997
• Arg-Gly-Aspの構造類似体およびその修飾リポソームによる癌転移抑制.[共著]

  6-  11  -21  1997
• 機能性リポソームの医薬への応用

  日本病院薬剤師会雑誌  33-  735  -737  1997
• PETによりがんの転移過程を観察する[共著]

  奥 直人; 岡田 昌二  原子力工業  43-  (6)  74  -79  1997
• 知っておきたい200ワード:現代医学用語集

  医学のあゆみ  181-  860  -861  1997
• リポソーム化RGDによる癌転移抑制[共著]

  奥 直人; 徳留 嘉寛; 小池 千恵子; 岡田 昌二; 西川 尚之; 森 英登; 済木 育夫  DDS  12-  (1)  13  -18  1997
• Metabolic Methylation Is a Possible Genotoxicity-enhancing Process of Inorganic Arsenics. [共著]

  Mutat. Res.  394-  95  -101  1997
• Oral Delivery of Insulin by Using Surface Coating Liposomes. Improvement of Stability of Insulin in GI Tract. [共著]

  Int. J. Pharm.  157-  (1)  73  -80  1997
• Application of Long-circulating Liposomes to Cancer Photodynamic Therapy. [共著]

  Biol. Pharm. Bull.  20-  (6)  670  -673  1997
• Cell-nuclear Accumulation of 72-kDa Stress Protein Induced by Dimethylated Arsenics. [共著]

  Koichi KATO; Kenzo YAMANAKA; Masayuki NAKANO; Akira HASEGAWA; Naoto OKU; Shoji OKADA  Biol. Pharm. Bull.  20-  (4)  364  -369  1997
• Application of Liposomes for Cancer Metastasis. [共著]

  Adv. Drug Delivery Rev.  24-  215  -223  1997
• DNA Single-strand Breaks in L-132 Cells Resulting from Inhibition of Repair Polymerization Shortly after Exposure to Dimethylarsinic Acid. [共著]

  Kenzo YAMANAKA; Hirotaka HAYASHI; Koichi KATO; Akira HASEGAWA; Naoto OKU; Shoji OKADA  Biol. Pharm. Bull.  20-  (2)  163  -167  1997
• 転移性癌細胞の生体内動態におけるインテグリンの関与 : PETを用いた解析

  小池 千恵子; 滝口 綾乃; 奥 直人; 岡田 昌二; 入村 達郎; 塚田 秀夫; 二ツ橋 昌実; 松浦 茂昭  日本分子生物学会年会プログラム・講演要旨集  19-  648  -648  1996/08
• Exo-vivo cytokine inducing activity of hydrophobized poly(maleic acid-alt-7,12-dioxaspiro-[5,6]-dodec-9-ene) [poly(MA-CDA)]

  Y Suda; M Hashimoto; JI Yasuoka; S Kusumoto; N Oku; JL Ding; RM Ottenbrite  JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS  11-  (2)  100  -109  1996/04
• Functional role of sialyl lewis X and fibronectin-derived RGDS peptide analogue on tumor cell arrest in lungs followed by extravasation.

  Ikuo Saiki; Chieko Koike; Aya Obata; Hideki Fujii; Jun Murata Makoto Kiso; Akira Hasegawa; Hiroyuki Komazawa; Hideo Tsukada; Ichiro Azuma; Shoji Okada; Naoto Oku.  Collected papers from the Institute of Immunological Science Hokkaido University  19-  166  -172  1996
• 機能性リポソームの開発と医薬への応用

  医学のあゆみ  178-  236  -237  1996
• Basic Study on Functional Liposomes and Their Application.

  Cellular and Molecular Biology Letters  1-  417  -427  1996
• Induction of Gene Damage by Dimethylarsenics, Main Metabolites of Inorganic Arsenics, throught the Interacton with Oxygen. [共著]

  3rd Internet World Congress.  1996
• Sulfatide Binds to Human and Animal Influenza A Viruses, and Inhibits the Viral Infection. [共著]

  Biochem. J.  318-  389  -393  1996
• Effect of Freeze-thawing on Phospholipid/Surfactant Mixed Bilayers. [共著]

  Naoto OKU; Junko TSUDERA; Kohta KUROHANE; Shoji OKADA  Chem. Pharm. Bull.  44-  (10)  1928  -1930  1996
• Application of Long-circulating Liposomes on Cancer Photodynamic Therapy.[共著]

  Progress in drug Delivery System  5-  133  -136  1996
• Trafficking of Various Long-circulating Liposomes in Tumor-bearing Mice Determined by Positron Emission Tomography.[共著]

  Biopharm. Drug Disposition  17-  435  -441  1996
• Liposomal Arg-Gly-Asp Analogs Effectively Inhibit Metastatic B16 Melanoma Colonization in Murine Lungs.[共著]

  Life Sci.  58-  (24)  2263  -2270  1996
• Differential Effect of UV-B and UV-C on DNA Damage in L-132 Cells.[共著]

  Biol. Pharm. Bull.  19-  (5)  721  -725  1996
• Effect of Serum Protein Binding on Real-time Trafficking of Liposomes with Different Charges Analyzed by Positron Emission Tomography.[共著]

  Biochim. Biophys. Acta  1280-  (1)  149  -154  1996
• Functional Role of Sialyl Lewis X and Fibrocectin-derived RGDS Peptide Analogue on Tumor Cell Arrest in Lungs Followed by Extravasation.[共著]

  Int. J. Cancer  65-  (6)  833  -839  1996
• Dimethylarsenics Reveal DNA Damage Induced by Superoxide Anion Radicals.[共著]

  Kenji KAWAGUCHI; Naoto OKU; Ken RIN; Kenzo YAMANAKA; Shoji OKADA  Biol. Pharm. Bull.  19-  (4)  551  -553  1996
• PET Can Image Cell Trafficking in Vivo : An approach for the Study on Tumor Metastasis.[共著]

  Proceedings of the Fifth International Conference: Peace through Mind/Brain Science  20  -26  1996
• Antitumor Activity of Vincristine Encapsulated in Glucuronide-modified Long-circulating Liposomes in Mice Bearing Meth A Sarcoma.[共著]

  Biochim. Biophys. Acta  1279-  (1)  70  -74  1996
• PEI(6), A NEW BASIC SECRETAGOGUE IN RAT PERITONEAL MAST-CELLS - CHARACTERISTICS OF POLYETHYLENIMINE PEI(6) RESEMBLE THOSE OF COMPOUND-48/80

  T SUZUKINISHIMURA; N OKU; M NANGO; MK UCHIDA  GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM  26-  (6)  1171  -1178  1995/10
• REAL-TIME ANALYSIS OF LIPOSOMAL TRAFFICKING IN TUMOR-BEARING MICE BY USE OF POSITRON EMISSION TOMOGRAPHY

  N OKU; Y TOKUDOME; H TSUKADA; S OKADA  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES  1238-  (1)  86  -90  1995/08
• 癌の転移が起きるまで[共著]

  化学と医学の教室  120-  32  -35  1995
• サポニンの好中球活性化 [共著]

  薬学雑誌  115-  (7)  528  -536  1995
• 機能性リポソームの基礎と応用に関する研究

  薬学雑誌  115-  (7)  483  -498  1995
• 高分子デリバリーを目的とした温度感受性リポソームの開発 [共著]

  奥 直人; 藤本 佳子; 鳴瀬 諒子; 土井 香苗子; 湯山 ゆきの; 岡田 昌二  Drug Delivery System  10-  (2)  99  -104  1995
• Permeability Change of the Liposomal Membrane Induced by Interleukin-1α[共著]

  J. Biochem.  118-  832  -835  1995
• Real-time PET Analysis of Metastatic Tumor Cell Trafficking in Vivo and Its Relation to Adhesion Properties.[共著]

  Biochim. Biophys. Acta  1238-  99  -106  1995
• Real-time Analysis of Liposomal Trafficking.[共著]

  Progress in Drug Delivery System  4-  1  -8  1995
• Real-time Analysis of Liposomal Trafficking in Tumor-bearing Mice by Use of Positron Emission Tomography.[共著]

  Biochim. Biophys. Acta  1238-  (1)  86  -90  1995
• Site-specific Protein Synthesis in Liver Regeneration Determined by PET. [共著]

  J. Nucl. Med.  36-  (4)  628  -631  1995
• Chaperonin-Repairable Subtle Incompleteness of Protein Assembly Induced by a Substitution of Hydrogen with Deuterium : Effect of GroE on Deuterated Ribulose 1,5-Bisphosphate Carboxylase.[共著]

  Plant Cell Physiol.  36-  (3)  419  -423  1995
• Therapeutic Efficacy of 5-fluorouracil prodrugs Using Endogenous Serum Proteins as Drug Carriers : A new Strategy in Drug Delivery System.[共著]

  Biol. Pharm. Bull.  18-  (1)  181  -184  1995
• DNA-strand Breaks Induced by Dimethylarsinic Acid, a Metabolite of Inorganic Arsenics, Are Strongly Enhanced by Superoxide Anion Radicals.[共著]

  Biol. Pharm. Bull.  18-  (1)  45  -48  1995
• EX-VIVO BIOLOGICAL-ACTIVITY OF SYNTHETIC POLYCARBOXYLIC POLYANIONS

  Y SUDA; S KUSUMOTO; N OKU  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  208-  213  -POLY  1994/08
• POSITRON EMISSION TOMOGRAPHY ANALYSIS OF METASTATIC TUMOR-CELL TRAFFICKING

  N OKU; C KOIKE; M SUGAWARA; H TSUKADA; T IRIMURA; S OKADA  CANCER RESEARCH  54-  (10)  2573  -2576  1994/05
• ARACHIDONIC ACID-SELECTIVE PHOSPHOLIPASE-A2 IS CRUCIAL IN THE CYTOTOXIC ACTION OF TUMOR-NECROSIS-FACTOR

  M HAYAKAWA; N ISHIDA; K TAKEUCHI; S SHIBAMOTO; T HORI; N OKU; F ITO; M TSUJIMOTO  JOURNAL OF CELLULAR BIOCHEMISTRY  47  -47  1994
• リポソーム化製剤の経口投与への応用[共著]

  3-  89  -97  1994
• 腫瘍壊死因子の腫瘍細胞傷害活性の解析と抗癌剤への応用 [共著]

  薬学研究の進歩  10-  55  -66  1994
• Application of RES-avoiding liposomes encapsulated adriamycin for cancer therapy.

  Oku Naoto; Doi Kanako  Drug Delivery System  9-  (2)  89  -95  1994
• Long circulating liposomes [共著]

  Crit. Rev. in therapeut. Drug Carrier Syst.  11-  231  -270  1994
• New macromolecules for targeting of bioactive compounds. [共著]

  Macromolecular Reports  A31-  1077  -1083  1994
• Potential usage of thermosensitive liposomes for macromolecule delivery.[共著]

  Biochim. Biophys. Acta  1191-  389  -391  1994
• TYROSINE PHOSPHORYLATION OF BETA-CATENIN AND PLAKOGLOBIN ENHANCED BY HEPATOCYTE GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR IN HUMAN CARCINOMA-CELLS

  S SHIBAMOTO; M HAYAKAWA; K TAKEUCHI; T HORI; N OKU; K MIYAZAWA; N KITAMURA; M TAKEICHI; F ITO  CELL ADHESION AND COMMUNICATION  1-  (4)  295  -305  1994
• Therapeutic effect of reticuloendothelial system(RES)-Avoiding liposomes containing a phospholipid analogue of 5-fluorouracil, dipalmitoylphosphatidylfluorouridine, in Meth A sarcoma-bearing mice.[共著]

  Biol. Pharm. Bull.  17-  (10)  1414  -1416  1994
• Utilization of liposome for oral dosage form

  Progress in Drug Delivery System  3-  89  -97  1994
• Therapeutic effect of adriamycin encapsulated in long-circulating liposomes on Meth-A-sarcoma-bearing mice [共著]

  Int. J. Cancer  58-  (3)  415  -419  1994
• Study on the cytotoxic action of tumor necrosis factor

  10-  55  -66  1994
• Application of RES-avoiding liposomes encapsulated adriamycin for cancer therapy

  Naoto Oku; Kanako Doi  Drug Delivery Systems  9-  (2)  89  -95  1994
• Liposomes : The Long-term Stability and the Topical Effect to the Skin.[共著]

  J. Soc. Consmet. Chem. Jpn.  27,216-226-  1993
• Liposomal Applications to Cancer Therapy. [共著]

  J. Bioact. Compat. Polymers.  8,158-177-  1993
• The synthesis and Their in Vitro and in Vivo Stability of 5-Fluorouracil Prodrugs which Possess Serum Albumin Binding Potency. [共著]

  Biol. Pharm. Bull.  16,876-878-  1993
• Stimulation of Prostaglandin Production by Hepatocyte Growth Factor in Human Gastric Carcinoma Cells. [共著]

  FEBS Lett.  334,331-334-  1993
• Arachidonic Acid-selective Cytosolic Phospholipase A2 Is Crucial in the Cytotoxic Action of Tumor Necrosis Factor. [共著]

  J. Biol. Chem.  268,11290-11295-  1993
• Tumor Imaging with Technetium-99m-DTPA Encapsulated in RES-avoiding Liposomes. [共著]

  Nucl. Med. Biol.  20,407-412-  1993
• TUMOR ACCUMULATION OF NOVEL RES-AVOIDING LIPOSOMES

  N OKU; Y NAMBA; S OKADA  BIOCHIMICA ET BIOPHYSICA ACTA  1126-  (3)  255  -260  1992/06
• Liposomal Application in DDS : Preparation of RES-avoiding Liposomes.

  Applied Cell Biology  9,53-61-  1992
• Liposomes : The Long-term Stability and the Topical Effect to the Skin. [共著]

  17th IFSCC International Congress Yokohama  1,172-192-  1992
• Tumor Accumulation of Glucuronide-modified RES-avoiding Liposomes.[共著]

  Progress in Drug Delivery System  1,31-42-  1992
• Modified Polyanionic Polymers(1) : Grafting of Hydrophobic Group onto Poly(maleic acid-alt-3,4-dihydroxyphenylprop-1-ene)to improve the Affinity for Cell Membranes. [共著]

  J. Bioact. Compat. Polymers  7,15-24-  1992
• LIPOSOMAL MODIFICATION WITH URONATE, WHICH ENDOWS LIPOSOMES WITH LONG CIRCULATION INVIVO, REDUCES THE UPTAKE OF LIPOSOMES BY J774-CELLS INVITRO

  Y NAMBA; N OKU; F ITO; T SAKAKIBARA; S OKADA  LIFE SCIENCES  50-  (23)  1773  -1779  1992
• Hepatocyte Growth Factor and Transforming Growth Facytor-beta Stimulate both Cell Growth and Migration of Human Gastric Adenocarcinoma Cells. [共著]

  Cell Struct. Funct.  17,185-190-  1992
• Modified Polyanionic Polymers for Enhanced Cell Membrane Interaction. [共著]

  J. Bioact. Compat. Polymers  7,275-287-  1992
• Solubilization of Human Placental Tumor Necrosis Factor Receptors as a Complex with a Guanine Nucleotide-binding Protein. [共著]

  Arch. Biochem. Biophys.  286,323-329-  1991
• Involvement of Prostaglandin-Producting Pathway in the Cytotoxic Action of Tumor Necrosis Factor. [共著]

  Cell Struct. Funct.  16,333-340-  1991
• Molecular Recognition Systems on the Plasma Membrane : Roles Membrane Lipids.

  Shibamoto Sayumi; Oku Naoto  Membrane  16-  (1)  15  -25  1991
• Liposomal Membrane.

  Rinsyobyori  91,225-237-  1991
• Phospholipids in Clinical Applications.

  Namba Yukihiro; Oku Naoto  Drug Delivery System  6,339-348-  (5)  339  -348  1991
• Prostaglandins Antagonize Fibroblast Proliferation Stimulated by Tumor Necrosis Factor. [共著]

  Biochem. Biophys. Res. Commun.  174,758-766-  1991
• Inhibitory Effect of Local Anesthetics on Na⁺/H⁺ Antiporter-reconstituted Vesicles.

  Hiroshima J. Anesthesia,  26-  (2)  215  -218  1990
• Glucuronate-Modified Liposomes with Prolonged Circulation Time. [共著]

  Chem. Pharm. Bull.  38,1663-1666-  1990
• Growth Inhibition of Human Fibroblasts by Epidermal Growth Factor in the Presence of Arachidonic Acid. [共著]

  Biochem. Biophys. Res. Commun.  169,959-965-  1990
• Effect of Local Anesthetics on Na⁺/H⁺ Antiporter in Brush Border Membrane-Reconstituted Vesicles. [共著]

  Life Sci.  47,1129-1133-  1990
• Liposomes and DDS. [共著]

  Bio-Industry.  7,508-516-  1990
• Synthetic Polycations, Polyethylenimines and Polyallylamines Release Histamine from Rat Cells. [共著]

  Jpn. J. Pharmacol.  51,279-290-  1989
• Tumor Necrosis Factor Is Cytotoxic to Human Fibroblasts in the Presence of Exogenous Arachidonic Acid. [共著]

  Exp. Cell Res.  185,41-49-  1989
• Possible Role of Prostaglandins as Negative Regulators in Growth Stimulation by Tumor Necrosis Factor and Epidermal Growth Factor in Human Fibroblasts. [共著]

  J. Cell. Physiol.  141,275-280-  1989
• The Effect of Local Anesthetics on Na⁺/H⁺ Antiporter-reconstituted Vesicles.

  Hiroshima J. Anesthesia.  25,301-303-  1989
• 1-O-Palmity-D-glucuronate Endows Liposomes with Long Half-life In Vivo. [共著]

  Chem. Lett.  1989,2145-2148-  1989
• Cancer Chemotherapy Administered by Activated Carbon Particles and Liposomes. [共著]

  Crit. Rev. Oncol. /Hematol.  9,319-350-  1989
• Effects of Tumor Necrosis Factor on Cell Growth and Expression of Transferrin Receptors in Human Fibrolasts. [共著]

  Cell Struct. Funct.  13,425-433-  1988
• Reconstitution of Na⁺/H⁺ Antiporter : A New Method for the Determination of H⁺ Efflux from Na⁺ Antiporter-reconstituted Vesicles. [共著]

  J. Pharmacobio-Dyn.  11,669-673-  1988
• A Study on the Interaction of Local Anesthetics with Liposomal Membrane

  Hiroshima J. Anesthesia  24,169-175-  1988
• PROTON-INDUCED MEMBRANE-FUSION OF LIPOSOMES CONTAINING PH-SENSITIVE POLYMER

  N OKU; K TAKAO; S SHIBAMOTO; F ITO; H GONDO; M NANGO  JOURNAL OF PHARMACOBIO-DYNAMICS  10-  (5)  S134  -S134  1987/05
• HISTAMINE-RELEASE FROM RAT MAST-CELLS BY THE SYNTHETIC POLYCATIONS INDUCING LIPOSOMAL MEMBRANE-FUSION

  T SUZUKI; N OKU; M NANGO; MK UCHIDA  JAPANESE JOURNAL OF PHARMACOLOGY  43-  P177  -P177  1987
• Applications of Liposomes as Microcapsules for Drug Delivery : Effects of Freezing and Drying on Liposomal Properties.

  Jpn. J. Freezing and Drying.  33,13-19-  1987
• Distinct Effects of Na⁺ and Li⁺ on the Induction of Morphological Changes in A431 Cells Mediated by Epidermal Growth Factor. [共著]

  Cell Struct. Funct.  12,23-33-  1987
• pH-Dependent Fusion of Lipid Vesicles Induced by Proton-Sensitive Polymer. [共著]

  Chem. Lett.  1987,1699-1702-  1987
• Tumor Necrosis Factro-Induced Permeability Increase of Negatively Charged Phospholipid Vesicles. [共著]

  J. Biochem.  102,1303-1310-  1987
• Low pH-Induced Membrane Fusion of Lipid Vesicles Containing Proton-Sensitive Polymer.[共著]

  Biochemistry  26,8145-8150-  1987
• Transmembrane Electron Transfer as Catalyzed by Poly-(ethylenimine)-Linked Manganese Porphyrins. [共著]

  J. Am. Chem. Soc  108,5865-5871-  1986
• The Fusogenic Effect of Synthetic Polycations on Negatively Charged Lipid Bilayers. [共著]

  J. Biochem.  100,935-944-  1986
• EGF-INDUCED MORPHOLOGICAL-CHANGES IN HUMAN EPIDERMOID CARCINOMA CELL LINE-A431 - EFFECT OF LI+ ON THE SIGNAL TRANSDUCTION

  N EMURA; N YAMAGUCHI; S SHIBAMOTO; N OKU; F ITO  CELL STRUCTURE AND FUNCTION  10-  (4)  482  -482  1985/12
• Artificial Membrane : Progress in Liposome Techonology'

  Fragrance J.  64,103-111-  1984
• Differential Effects of Alkali Metal Chlorides on Formation of Giant Liposomes by Freezing and Thawing and Dialysis. [共著]

  Biochemistry  22,855-863-  1983
• Solubilization of Phospholipids by Chaotropic Ion Solutions. [共著]

  J. Biol. Chem.  258,8733-8738-  1983
• Formation of Giant Liposomes form Lipids in Chaotropic Ion Solutions.[共著]

  Biochim. Biophys. Acta,  734,54-61-  1983
• Studies on the Interaction of HVJ(Sendai Virus) with Liposomal Membranes. HVJ-Induced Permeability Increase of Liposomes Containing Glycophorin. [共著]

  Virology  116,419-427-  1982
• Electron Microscopic Study on the Interaction of Sendai Virus with Liposomes Containing Glycophorin. [共著]

  Biochim. Biophys. Acta  691,91-96-  1982
• A Simple Procedure for the Determination of the trapped Volume of Liposomes. [共著]

  Biochim. Biophys. Acta  691,332-340-  1982
• Preparation of Giant Liposomes.[共著]

  Biochim. Biophys. Acta  692,384-388-  1982
• Studies on the Interaction of Sendai Virus with Liposomal Membranes. Sendai Virus-Induced Agglutination of Liposomes Containing Glycophorin. [共著]

  Biochim. Biophys. Acta  646,36-42-  1981
• Artificial Membranes, a model of Biomembranes.

  Taishya  18,81-89-  1981
• Selective Release of Nonelectrolytes from Liposomes upon Perturbation of Bilayers by Temperature Change or Polyene Antibiotics. [共著]

  Biochim. Biophys. Acta  595,277-290-  1980
• 機能性リポソームの基礎と応用に関する研究

  11-  (6)  723  -729

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• 特許第5299922号:HB−EGF結合性タンパク質複合体  2013/06/28

  南野 哲男, 目加田 英輔, 浅井 知浩, 高島 成二, 朝野 仁裕, 奥 直人  国立大学法人大阪大学, 静岡県公立大学法人  201303013133177810
• 特許第5004464号:糖鎖修飾リポソーム  2012/06/01

  奥 直人, 南部 由利  大塚化学株式会社  201303038027147432
• 特許第4989241号:[18F]標識化合物及びその製造方法、並びに[18F]標識リポソーム及び[18F]標識リポソーム製剤の製造方法  2012/05/11

  塚田 秀夫, 原田 典弘, 奥 直人, 赤井 周司, 浦上 武雄  静岡県公立大学法人, 浜松ホトニクス株式会社  201303081112373290
• 特許第4881327号:抗腫瘍活性物質のリポソーム製剤  2011/12/09

  奥 直人  大鵬薬品工業株式会社  201303019478365595
• WO2010-090222:HB−EGF結合性タンパク質複合体  2010/08/12

  南野 哲男, 目加田 英輔, 浅井 知浩, 高島 成二, 朝野 仁裕, 奥 直人  国立大学法人大阪大学, 静岡県公立大学法人  201203068293535471
• 特許第4502368号:有機リン酸エステル無水物の製造方法  2010/04/30

  南後 守, 出羽 毅久, 田中 俊樹, 山下 啓司, 家田 由佳利, 吉田 清貴, 森田 一行, 奥 直人, 近藤 勝義  竹本油脂株式会社  201103028046484857
• 特許第4442864号:リン脂質誘導体及び遺伝子導入キャリア  2010/01/22

  南後 守, 出羽 毅久, 田中 俊樹, 山下 啓司, 家田 由佳利, 吉田 清貴, 森田 一行, 奥 直人, 近藤 勝義  竹本油脂株式会社  201103016748979031
• 特許第4439120号:新生血管特異的ペプチド  2010/01/15

  奥 直人, 荻野 晃一, 石川 大, 田中 理紀, 瀧 孝雄  大塚製薬株式会社  201103044247301853
• WO2009-125858:2−インドリノン誘導体を含有する脂質分散体製剤  2009/10/15

  奥 直人, 馬場 一彦  静岡県公立大学法人, 大鵬薬品工業株式会社  201103003369090146
• 特開2008-184412:[18F]標識化合物及びその製造方法、並びに[18F]標識リポソーム及び[18F]標識リポソーム製剤の製造方法  2008/08/14

  塚田 秀夫, 原田 典弘, 奥 直人, 赤井 周司, 浦上 武雄  奥 直人, 赤井 周司, 浜松ホトニクス株式会社  200903055378796576
• WO2008-026781:逆標的化脂質小胞体  2008/03/06

  奥 直人, 浅井 知浩, 浦上 武雄  奥 直人, アステラス製薬株式会社  201003072957477760
• WO2007-088952:抗腫瘍活性物質のリポソーム製剤  2007/08/09

  奥 直人  大鵬薬品工業株式会社  200903083163228635
• 特開2007-153787:糖鎖修飾リポソーム  2007/06/21

  奥 直人, 南部 由利  大塚化学株式会社  200903080348083936
• WO2006-095798:フィトステロールを含んだリポソームを含有する抗癌用経口組成物、該リポソームによる癌の予防又は治療  2006/09/14

  今中 宏真, 石角 篤, 奥 直人  サンスター株式会社  200903023592157280
• 特開2005-247751:有機リン酸エステル無水物の製造方法  2005/09/15

  南後 守, 出羽 毅久, 田中 俊樹, 山下 啓司, 家田 由佳利, 吉田 清貴, 森田 一行, 奥 直人, 近藤 勝義  竹本油脂株式会社  200903088469043282
• 特開2005-247750:リン脂質誘導体及び遺伝子導入キャリア  2005/09/15

  南後 守, 出羽 毅久, 田中 俊樹, 山下 啓司, 家田 由佳利, 吉田 清貴, 森田 一行, 奥 直人, 近藤 勝義  竹本油脂株式会社  200903015544653353
• 特開2004-331630:PEG結合ペプチド  2004/11/25

  前田 典之, 奥 直人  日本精化株式会社  200903021622533351
• 特開2003-221336:抗悪性腫瘍剤  2003/08/05

  奥 直人, 馬場 一彦  大鵬薬品工業株式会社  200903021935479110
• WO2000-023476:新生血管特異的ペプチド  2000/04/27

  奥 直人, 荻野 晃一, 石川 大, 田中 理紀, 瀧 孝雄  大塚製薬株式会社  200903034406303524
• WO1999-043752:負電荷物質を輸送するための組成物  1999/09/02

  奥 直人, 南後 守, 宮崎 秀樹, 榊原 裕幸  株式会社ディナベック研究所  200903048257613133
• 特開平11-199488:抗腫瘍薬のリポソーム化製剤  1999/07/27

  奥 直人, 周東 智, 松田 彰  三共株式会社  200903007736440881
• 特許第2700276号:リポソーム  1997/10/03

  難波 幸弘, 榊原 敏之, 奥 直人  日本精化株式会社  201103014664767125
• 特開平8-225457:癌転移抑制用組成物  1996/09/03

  森 英登, 西川 尚之, 小島 政芳, 奥 直人  富士写真フイルム株式会社  200903044047090272
• 特開平6-122634:リポソームを用いるガン診断薬およびガン治療薬  1994/05/06

  難波 幸弘, 榊原 敏之, 奥 直人  日本精化株式会社  200903048194298283

Awards & Honors

• 2019/09 Liposome Research Days The Alec D. Bangham, MD, FRS Achievement Award for Lifetime Contributions in Liposome Researvch
   

  受賞者: Naoto Oku
• 2016 日本薬学会賞 受賞
   

  受賞者: 奥 直人
• 2015 日本薬剤学会タケル・アヤ・ヒグチ記念賞 受賞
   

  受賞者: 奥 直人
• 2012 日本DDS学会永井賞 受賞
   

  受賞者: 奥 直人
• 1995 日本薬学会奨励賞 受賞
   JPN 

  受賞者: 奥直人

Research Grants & Projects

• ポジトロンCTを用いる癌転移機構の研究
• リポソームの薬物送達システムへの応用
• Study on Metastasis using Positron Emission Tomography
• Application of Liposomes for Drug Delivery System