Kano Masanobu

Researcher Information

Affiliation

Advanced Comprehensive Research Organization (ACRO) Specially Appointed Professor

Degree

• MD（PhD）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901046364384058

J-Global ID

• 200901046364384058

Research Interests

• 脳プロ   包括脳ネットワーク・将来計画委員会   包括脳ネットワーク・リソース・技術開発委員会   包括脳ネットワーク・包括支援委員会・脳神経回路機能   包括脳ネットワーク   統合脳・神経回路機能   シナプス伝達   calmodulin-dependent protein kinaseII   calmodulin-dependent protein kinase II   カルシウム   protein kinaseA   神経回路   シナプス形成   神経科学   脳・神経   逆行性シグナル   神経活動   海馬   カルシウムチャネル   NMDA受容体   シナプス伝達調節   シナプス除去   マウス   発達   生後発達   長期増強   多重支配   GABA受容体   Ca^<++>   シナプス   小脳スライス   パッチクランプ   抑制性シナプス   登上線維   プルキンエ細胞   小脳   

Research Areas

• Life sciences / Neuroscience - general

Academic & Professional Experience

• 2023/04 - Today  Teikyo UniversityAdvanced Comprehensive Research OrganizationProject Professor
• 2007/09 - 2023/03  Graduate School of Medicine and Faculty of Medicine,The University of TokyoNeurophysiologyProfessor
• 2005/10 - 2007/08  Osaka UniversityGraduate School of Medicine, Division of Physiological Sciences
• 1990/04 - 1995/09  Jichi Medical UniversitySchool of Medicine
• 1986/04 - 1990/03  Jichi Medical UniversitySchool of Medicine

Research Activity Information

Published Papers

• A comprehensive suite for extracting neuron signals across multiple sessions in one-photon calcium imaging

  Pablo Vergara; Yuteng Wang; Sakthivel Srinivasan; Zhe Dong; Yu Feng; Iyo Koyanagi; Deependra Kumar; Yoan Chérasse; Toshie Naoi; Yuki Sugaya; Takeshi Sakurai; Masanobu Kano; Tristan Shuman; Denise Cai; Masashi Yanagisawa; Masanori Sakaguchi

  Nature Communications Springer Science and Business Media LLC 16 (1) 2025/04
• Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning.

  Huu Hoang; Shinichiro Tsutsumi; Masanori Matsuzaki; Masanobu Kano; Keisuke Toyama; Kazuo Kitamura; Mitsuo Kawato

  PLoS computational biology 21 (3) e1012899  2025/03
• Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum.

  Hisako Nakayama; Taisuke Miyazaki; Manabu Abe; Maya Yamazaki; Yoshinobu Kawamura; Myeongjeong Choo; Kohtarou Konno; Shinya Kawata; Naofumi Uesaka; Kouichi Hashimoto; Mariko Miyata; Kenji Sakimura; Masahiko Watanabe; Masanobu Kano

  Communications biology 7 (1) 806 - 806 2024/07 [Refereed]
  
• Layer specific regulation of critical period timing and maturation of mouse visual cortex by endocannabinoids.

  Taisuke Yoneda; Katsuro Kameyama; Takahiro Gotou; Keiko Terata; Masahiro Takagi; Yumiko Yoshimura; Kenji Sakimura; Masanobu Kano; Yoshio Hata

  iScience 27 (6) 110145 - 110145 2024/06 [Refereed]
  
• Delayed gramicidin delivery through an intra-pipette capillary facilitates perforated patch recordings.

  Kosuke Kazashi; Kakeru Miura; Sota Ueda; Kazuhito Utsunomiya; Mari Kiriyama; Motoki Yagisawa; Masayuki Ikeda; Masanobu Kano; Toshihide Tabata

  Neuroscience research 2024/05 [Refereed]
  
• Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components reduces dimensions for reinforcement learning

  Huu Hoang; Shinichiro Tsutsumi; Masanori Matsuzaki; Masanobu Kano; Mitsuo Kawato; Kazuo Kitamura; Keisuke Toyama

  eLife eLife Sciences Publications, Ltd 12 2023/09 [Refereed]
  
• Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice.

  Koji Ikezoe; Naoki Hidaka; Satoshi Manita; Masayoshi Murakami; Shinichiro Tsutsumi; Yoshikazu Isomura; Masanobu Kano; Kazuo Kitamura

  Communications biology 6 (1) 924 - 924 2023/09 [Refereed]
  
• PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum

  Yuto Okuno; Kazuto Sakoori; Kyoko Matsuyama; Miwako Yamasaki; Masahiko Watanabe; Kouichi Hashimoto; Takaki Watanabe; Masanobu Kano

  Frontiers in Molecular Neuroscience Frontiers Media SA 16 2023/06 [Refereed]
  
• Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders

  Kisho Obi-Nagata; Norimitsu Suzuki; Ryuhei Miyake; Matthew L. MacDonald; Kenneth N. Fish; Katsuya Ozawa; Kenichiro Nagahama; Tsukasa Okimura; Shoji Tanaka; Masanobu Kano; Yugo Fukazawa; Robert A. Sweet; Akiko Hayashi-Takagi

  Science Advances American Association for the Advancement of Science (AAAS) 9 (23) 2023/06 [Refereed]
  
• CaliAli, a tool for long-term tracking of neuronal population dynamics in calcium imaging

  Pablo Vergara; Yuteng Wang; Sakthivel Srinivasan; Yoan Cherasse; Toshie Naoi; Yuki Sugaya; Takeshi Sakurai; Masanobu Kano; Masanori Sakaguchi

  Cold Spring Harbor Laboratory 2023/05 [Refereed]
  
• Negative reward-prediction errors of climbing fiber inputs for cerebellar reinforcement learning algorithm

  Huu Hoang; Shinichiro Tsutsumi; Masanori Matsuzaki; Masanobu Kano; Keisuke Toyama; Kazuo Kitamura; Mitsuo Kawato

  Cold Spring Harbor Laboratory 2023/03 [Refereed]
  
• Maturation of GABAergic Synaptic Transmission From Neocortical Parvalbumin Interneurons Involves N-methyl-D-aspartate Receptor Recruitment of Cav2.1 Channels.

  Mahendra Singh; Kiran Sapkota; Kenji Sakimura; Masanobu Kano; Rita M Cowell; Linda Overstreet-Wadiche; John J Hablitz; Kazu Nakazawa

  Neuroscience 513 38 - 53 2023/03 [Refereed]
  
• Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex.

  Chiaki Itami; Naofumi Uesaka; Jui-Yen Huang; Hui-Chen Lu; Kenji Sakimura; Masanobu Kano; Fumitaka Kimura

  Proceedings of the National Academy of Sciences of the United States of America 119 (37) e2122700119  2022/09 [Refereed]
  
• Cerebellar climbing fibers convey behavioral information of multiplex modalities and form functional modules

  Koji Ikezoe; Naoki Hidaka; Satoshi Manita; Masayoshi Murakami; Shinichiro Tsutsumi; Yoshikazu Isomura; Masanobu Kano; Kazuo Kitamura

  Cold Spring Harbor Laboratory 2022/08 [Refereed]
  
• mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning

  Maria Harbers; Harumi Nakao; Takaki Watanabe; Kyoko Matsuyama; Shoichi Tohyama; Kazuki Nakao; Yasushi Kishimoto; Masanobu Kano; Atsu Aiba

  Cells MDPI AG 11 (13) 2004 - 2004 2022/06 [Refereed]
  
• A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo

  Masayuki Sakamoto; Masatoshi Inoue; Atsuya Takeuchi; Shigetaka Kobari; Tatsushi Yokoyama; Shin-ichiro Horigane; Sayaka Takemoto-Kimura; Manabu Abe; Kenji Sakimura; Masanobu Kano; Kazuo Kitamura; Hajime Fujii; Haruhiko Bito

  Cell Reports Methods Elsevier BV 100168 - 100168 2667-2375 2022/02 [Refereed]
  
• Carbon powder-filled microelectrode: An easy-to-fabricate probe for cellular electrochemistry

  Asuka Tsujimura; Yuhi Kamae; Hikaru Kawasaki; Haruki Nagai; Masanobu Kano; Toshihide Tabata

  Analytical Biochemistry Academic Press Inc. 629 1096-0309 2021/09 [Refereed]
  
• Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.

  Kazuya Toriumi; Stefano Berto; Shin Koike; Noriyoshi Usui; Takashi Dan; Kazuhiro Suzuki; Mitsuhiro Miyashita; Yasue Horiuchi; Akane Yoshikawa; Mai Asakura; Kenichiro Nagahama; Hsiao-Chun Lin; Yuki Sugaya; Takaki Watanabe; Masanobu Kano; Yuki Ogasawara; Toshio Miyata; Masanari Itokawa; Genevieve Konopka; Makoto Arai

  Redox biology 45 102057 - 102057 2021/09 [Refereed]
  
• mGluR1 signaling in cerebellar Purkinje cells: Subcellular organization and involvement in cerebellar function and disease.

  Miwako Yamasaki; Atsu Aiba; Masanobu Kano; Masahiko Watanabe

  Neuropharmacology 194 108629 - 108629 2021/08 [Refereed]
  
• Combining electrophysiology and optogenetics for functional screening of pyramidal neurons in the mouse prefrontal cortex

  Kenichiro Nagahama; Shuhei Fujino; Takaki Watanabe; Naofumi Uesaka; Masanobu Kano

  STAR Protocols Elsevier BV 2 (2) 100469 - 100469 2666-1667 2021/06 [Refereed]
  
• Masao Ito-A Visionary Neuroscientist with a Passion for the Cerebellum.

  Soichi Nagao; Hirokazu Hirai; Masanobu Kano; Michisuke Yuzaki

  Neuroscience 462 1 - 3 2021/05 [Refereed]
  
• Calcium imaging of adult-born neurons in freely moving mice.

  Alvaro Carrier-Ruiz; Yuki Sugaya; Deependra Kumar; Pablo Vergara; Iyo Koyanagi; Sakthivel Srinivasan; Toshie Naoi; Masanobu Kano; Masanori Sakaguchi

  STAR protocols 2 (1) 100238 - 100238 2021/03 [Refereed]
  
• mGluR1 Is a Molecular “Hub” for Synapse Elimination in the Developing Cerebellum

  Masanobu Kano; Takaki Watanabe; Naofumi Uesaka

  Contemporary Clinical Neuroscience Springer Nature 77 - 89 2627-5341 2021
• In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors.

  Beomjong Song; Chan Young Kang; Jun Hee Han; Masanobu Kano; Arthur Konnerth; Sangsu Bae

  Computational and structural biotechnology journal 19 2477 - 2485 2021 [Refereed]
  
• Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures.

  Yuki Sugaya; Masanobu Kano

  Frontiers in neural circuits 15 781113 - 781113 2021 [Refereed]
  
• An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum.

  Esther Suk King Lai; Hisako Nakayama; Taisuke Miyazaki; Takanobu Nakazawa; Katsuhiko Tabuchi; Kouichi Hashimoto; Masahiko Watanabe; Masanobu Kano

  Frontiers in neural circuits 15 676891 - 676891 2021 [Refereed]
  
• Improved hyperacuity estimation of spike timing from calcium imaging

  Huu Hoang; Masa-aki Sato; Shigeru Shinomoto; Shinichiro Tsutsumi; Miki Hashizume; Tomoe Ishikawa; Masanobu Kano; Yuji Ikegaya; Kazuo Kitamura; Mitsuo Kawato; Keisuke Toyama

  Scientific Reports Springer Science and Business Media LLC 10 (1) 2020/12 [Refereed]
  
• Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex

  Hiroaki Sacai; Kazuto Sakoori; Kohtarou Konno; Kenichiro Nagahama; Honoka Suzuki; Takaki Watanabe; Masahiko Watanabe; Naofumi Uesaka; Masanobu Kano

  Nature Communications Springer Science and Business Media LLC 11 (1) 2020/12 [Refereed]
  
• AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication

  Kunihiko Yamashiro; Kei Hori; Esther S.K. Lai; Ryo Aoki; Kazumi Shimaoka; Nariko Arimura; Saki F. Egusa; Asami Sakamoto; Manabu Abe; Kenji Sakimura; Takaki Watanabe; Naofumi Uesaka; Masanobu Kano; Mikio Hoshino

  iScience Elsevier BV 101820 - 101820 2589-0042 2020/11 [Refereed]
  
• Traceable stimulus-dependent rapid molecular changes in dendritic spines in the brain.

  Kazuya Kuboyama; Takafumi Inoue; Yuki Hashimotodani; Takuya Itoh; Tohsuke Suzuki; Aya Tetsuzawa; Yosuke Ohtsuka; Ryo Kinoshita; Ren Takara; Tohru Miyazawa; Pooja Gusain; Masanobu Kano; Maki K Yamada

  Scientific reports 10 (1) 15266 - 15266 2020/09 [Refereed]
  
• Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities.

  Kenichiro Nagahama; Kazuto Sakoori; Takaki Watanabe; Yusuke Kishi; Keita Kawaji; Michinori Koebis; Kazuki Nakao; Yukiko Gotoh; Atsu Aiba; Naofumi Uesaka; Masanobu Kano

  Cell reports 32 (11) 108126 - 108126 2020/09 [Refereed]
  
• A test potential booster for fast-scan cyclic voltammetry with an electrophysiological amplifier.

  Haruki Nagai; Taichi Yokoi; Masanobu Kano; Toshihide Tabata

  Analytical biochemistry 610 113934 - 113934 2020/09 [Refereed]
  
• Impairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and schizophrenia-like behavioral deficits

  Kazuya Toriumi; Stefano Berto; Shin Koike; Noriyoshi Usui; Takashi Dan; Kazuhiro Suzuki; Mitsuhiro Miyashita; Yasue Horiuchi; Akane Yoshikawa; Yuki Sugaya; Takaki Watanabe; Mai Asakura; Masanobu Kano; Yuki Ogasawara; Toshio Miyata; Masanari Itokawa; Genevieve Konopka; Makoto Arai

  Cold Spring Harbor Laboratory 2020/07 [Refereed]
  
• A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders

  Toshimitsu Suzuki; Toshifumi Suzuki; Matthieu Raveau; Noriko Miyake; Genki Sudo; Yoshinori Tsurusaki; Takaki Watanabe; Yuki Sugaya; Tetsuya Tatsukawa; Emi Mazaki; Atsushi Shimohata; Itaru Kushima; Branko Aleksic; Tomoko Shiino; Tomoko Toyota; Yoshimi Iwayama; Kentaro Nakaoka; Iori Ohmori; Aya Sasaki; Ken Watanabe; Shinichi Hirose; Sunao Kaneko; Yushi Inoue; Takeo Yoshikawa; Norio Ozaki; Masanobu Kano; Takeyoshi Shimoji; Naomichi Matsumoto; Kazuhiro Yamakawa

  Annals of Clinical and Translational Neurology Wiley 7 (7) 1117 - 1131 2328-9503 2020/06 [Refereed]
  
• Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations

  Yasuyuki Nagumo; Yoshifumi Ueta; Hisako Nakayama; Hironobu Osaki; Yuichi Takeuchi; Naofumi Uesaka; Masanobu Kano; Mariko Miyata

  Cell Reports Elsevier BV 31 (12) 107797 - 107797 2211-1247 2020/06 [Refereed]
  
• Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

  Deependra Kumar; Iyo Koyanagi; Alvaro Carrier-Ruiz; Pablo Vergara; Sakthivel Srinivasan; Yuki Sugaya; Masatoshi Kasuya; Tzong-Shiue Yu; Kaspar E. Vogt; Masafumi Muratani; Takaaki Ohnishi; Sima Singh; Catia M. Teixeira; Yoan Chérasse; Toshie Naoi; Szu-Han Wang; Pimpimon Nondhalee; Boran A.H. Osman; Naoko Kaneko; Kazunobu Sawamoto; Steven G. Kernie; Takeshi Sakurai; Thomas J. McHugh; Masanobu Kano; Masashi Yanagisawa; Masanori Sakaguchi

  Neuron Elsevier BV 107 (3) 1 - 14 0896-6273 2020/05 [Refereed]
  
• Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum

  Yurie Rai; Takaki Watanabe; Kyoko Matsuyama; Kenji Sakimura; Naofumi Uesaka; Masanobu Kano

  Neuroscience Elsevier BV 462 36 - 43 0306-4522 2020/04 [Refereed]
  
• A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System

  Erzsébet Farkas; Edina Varga; Balázs Kovács; Anett Szilvásy-Szabó; Antonieta Cote-Vélez; Zoltán Péterfi; Magdalini Matziari; Mónika Tóth; Dóra Zelena; Zsolt Mezriczky; Andrea Kádár; Dóra Kővári; Masahiko Watanabe; Masanobu Kano; Ken Mackie; Balázs Rózsa; Yvette Ruska; Blanka Tóth; Zoltán Máté; Ferenc Erdélyi; Gábor Szabó; Balázs Gereben; Ronald M. Lechan; Jean-Louis Charli; Patricia Joseph-Bravo; Csaba Fekete

  iScience Elsevier BV 23 (3) 100921 - 100921 2589-0042 2020/03 [Refereed]
  
• G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals

  Hakushun Sakairi; Yuji Kamikubo; Masayoshi Abe; Keisuke Ikeda; Arata Ichiki; Toshihide Tabata; Masanobu Kano; Takashi Sakurai

  ACS Chemical Neuroscience American Chemical Society (ACS) 11 (4) 567 - 578 1948-7193 2020/02 [Refereed]
  
• Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus.

  Ryo Saito; Michinori Koebis; Taku Nagai; Kimiko Shimizu; Jingzhu Liao; Bolati Wulaer; Yuki Sugaya; Kenichiro Nagahama; Naofumi Uesaka; Itaru Kushima; Daisuke Mori; Kazuaki Maruyama; Kazuki Nakao; Hiroki Kurihara; Kiyofumi Yamada; Masanobu Kano; Yoshitaka Fukada; Norio Ozaki; Atsu Aiba

  Translational psychiatry Springer Science and Business Media LLC 10 (1) 35 - 35 2020/02 [Refereed]
  
• mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory

  Harumi Nakao; Yasushi Kishimoto; Kouichi Hashimoto; Kazuo Kitamura; Miwako Yamasaki; Kazuki Nakao; Masahiko Watanabe; Masanobu Kano; Yutaka Kirino; Atsu Aiba

  Scientific Reports Springer Science and Business Media LLC 9 (1) 7353  2019/12 [Refereed]
  
• Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells

  Yusuke Sakai; Hidetoshi Kassai; Hisako Nakayama; Masahiro Fukaya; Tatsuya Maeda; Kazuki Nakao; Kouichi Hashimoto; Hiroyuki Sakagami; Masanobu Kano; Atsu Aiba

  Scientific Reports Springer Science and Business Media LLC 9 (1) 2799 - in press 2019/12 [Refereed]
  
• Endocannabinoid Signaling from 2-Arachidonoylglycerol to CB1 Cannabinoid Receptor Facilitates Reward-based Learning of Motor Sequence

  Hayate Tanigami; Mitsugu Yoneda; Yuki Tabata; Ryosuke Echigo; Yui Kikuchi; Maya Yamazaki; Yasushi Kishimoto; Kenji Sakimura; Masanobu Kano; Takako Ohno-Shosaku

  Neuroscience Elsevier BV 421 1 - 16 0306-4522 2019/11 [Refereed]
  
• Modular organization of cerebellar climbing fiber inputs during goal-directed behavior

  Shinichiro Tsutsumi; Naoki Hidaka; Yoshikazu Isomura; Masanori Matsuzaki; Kenji Sakimura; Masanobu Kano; Kazuo Kitamura

  eLife eLife Sciences Publications, Ltd 8 e47021  2019/10 [Refereed]
  
• Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2

  Sara Martínez-Torres; Laura Cutando; Antoni Pastor; Ako Kato; Kenji Sakimura; Rafael de la Torre; Emmanuel Valjent; Rafael Maldonado; Masanobu Kano; Andrés Ozaita

  Brain, Behavior, and Immunity Elsevier BV 81 399 - 409 0889-1591 2019/10 [Refereed]
  
• Developmental synapse remodeling in the cerebellum and visual thalamus

  Masanobu Kano; Takaki Watanabe

  F1000Research F1000 Research Ltd 8 1191 - 1191 2019/07 [Refereed]
  
• Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics

  Masatoshi Inoue; Atsuya Takeuchi; Satoshi Manita; Shin-ichiro Horigane; Masayuki Sakamoto; Ryosuke Kawakami; Kazushi Yamaguchi; Kouhei Otomo; Hiroyuki Yokoyama; Ryang Kim; Tatsushi Yokoyama; Sayaka Takemoto-Kimura; Manabu Abe; Michiko Okamura; Yayoi Kondo; Sean Quirin; Charu Ramakrishnan; Takeshi Imamura; Kenji Sakimura; Tomomi Nemoto; Masanobu Kano; Hajime Fujii; Karl Deisseroth; Kazuo Kitamura; Haruhiko Bito

  Cell Elsevier BV 177 (5) 1346 - 1360.e24 0092-8674 2019/05 [Refereed]
  
• Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.

  Hashimotodani Y; Karube F; Yanagawa Y; Fujiyama F; Kano M

  Cell reports 25 (10) 2704 - 2715.e4 2018/12 [Refereed]
  
• Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice.

  Kikuchihara S; Sugio S; Tanaka KF; Watanabe T; Kano M; Yamazaki Y; Watanabe M; Ikenaka K

  Journal of neurochemistry Wiley 147 (3) 344 - 360 0022-3042 2018/11 [Refereed]
  
• Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB₁ cannabinoid receptor-deficient mice.

  Yoshida K; Kita Y; Tokuoka SM; Hamano F; Yamazaki M; Sakimura K; Kano M; Shimizu T

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 (2) fj201801203R - 2497 0892-6638 2018/09 [Refereed]
  
• Control of excessive neural circuit excitability and prevention of epileptic seizures by endocannabinoid signaling

  Yuki Sugaya; Masanobu Kano

  Cellular and Molecular Life Sciences Birkhauser Verlag AG 75 (15) 2793 - 2811 1420-9071 2018/08 [Refereed]
  
• A mutant HCN4 channel in a family with bradycardia, left bundle branch block, and left ventricular noncompaction.

  Ryosuke Yokoyama; Koshi Kinoshita; Yukiko Hata; Masayoshi Abe; Kenta Matsuoka; Keiichi Hirono; Masanobu Kano; Makoto Nakazawa; Fukiko Ichida; Naoki Nishida; Toshihide Tabata

  Heart and vessels 33 (7) 802 - 819 0910-8327 2018/07 [Refereed]
  
• Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.

  Kano M; Watanabe T; Uesaka N; Watanabe M

  Cerebellum (London, England) 17 (6) 722 - 734 1473-4222 2018/07 [Refereed]
  
• Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.

  Naofumi Uesaka; Manabu Abe; Kohtarou Konno; Maya Yamazaki; Kazuto Sakoori; Takaki Watanabe; Tzu-Huei Kao; Takayasu Mikuni; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano

  Neuron 97 (4) 796 - 805 0896-6273 2018/02 [Refereed]
  
• Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.

  Shuo Chen; Adam Z Weitemier; Xiao Zeng; Linmeng He; Xiyu Wang; Yanqiu Tao; Arthur J Y Huang; Yuki Hashimotodani; Masanobu Kano; Hirohide Iwasaki; Laxmi Kumar Parajuli; Shigeo Okabe; Daniel B Loong Teh; Angelo H All; Iku Tsutsui-Kimura; Kenji F Tanaka; Xiaogang Liu; Thomas J McHugh

  Science (New York, N.Y.) 359 (6376) 679 - 684 0036-8075 2018/02 [Refereed]
  
• Presynaptic Mechanisms Mediating Retrograde Semaphorin Signals for Climbing Fiber Synapse Elimination During Postnatal Cerebellar Development

  Naofumi Uesaka; Masanobu Kano

  Cerebellum Springer New York LLC 17 (1) 17 - 22 1473-4230 2018/02 [Refereed]
  
• Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders

  Hirokazu Hirai; Masanobu Kano

  Current Opinion in Pharmacology Elsevier Ltd 38 51 - 58 1471-4973 2018/02 [Refereed]
  
• Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network

  Jean-Marc Good; Michael Mahoney; Taisuke Miyazaki; Kenji F. Tanaka; Kenji Sakimura; Masahiko Watanabe; Kazuo Kitamura; Masanobu Kano

  CELL REPORTS CELL PRESS 21 (8) 2066 - 2073 2211-1247 2017/11 [Refereed]
  
• Alternative splicing in the C-terminal tail of Ca(v)2.1 is essential for preventing a neurological disease in mice

  Tomonori Aikawa; Takaki Watanabe; Taisuke Miyazaki; Takayasu Mikuni; Minoru Wakamori; Miyano Sakurai; Hidenori Aizawa; Nobutaka Ishizu; Masahiko Watanabe; Masanobu Kano; Hidehiro Mizusawa; Kei Watase

  HUMAN MOLECULAR GENETICS OXFORD UNIV PRESS 26 (16) 3094 - 3104 0964-6906 2017/08 [Refereed]
  
• Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

  Myeongjeong Choo; Taisuke Miyazaki; Maya Yamazaki; Meiko Kawamura; Takanobu Nakazawa; Jianling Zhang; Asami Tanimura; Naofumi Uesaka; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 8 (1) 195  2041-1723 2017/08 [Refereed]
  
• Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells

  Taisuke Miyazaki; Miwako Yamasaki; Kouichi Hashimoto; Kazuhisa Kohda; Michisuke Yuzaki; Keiko Shimamoto; Kohichi Tanaka; Masanobu Kano; Masahiko Watanabe

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 114 (28) 7438 - 7443 0027-8424 2017/07 [Refereed]
  
• Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

  Nobuhiro Nakai; Masatoshi Nagano; Fumihito Saitow; Yasuhito Watanabe; Yoshinobu Kawamura; Akiko Kawamoto; Kota Tamada; Hiroshi Mizuma; Hirotaka Onoe; Yasuyoshi Watanabe; Hiromu Monai; Hajime Hirase; Jin Nakatani; Hirofumi Inagaki; Tomoyuki Kawada; Taisuke Miyazaki; Masahiko Watanabe; Yuka Sato; Shigeo Okabe; Kazuo Kitamura; Masanobu Kano; Kouichi Hashimoto; Hidenori Suzuki; Toru Takumi

  SCIENCE ADVANCES AMER ASSOC ADVANCEMENT SCIENCE 3 (6) e1603001  2375-2548 2017/06 [Refereed]
  
• Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signaling.

  Fukudome Y; Ohno-Shosaku T; Matsui M; Omori Y; Watanabe M; Kano M

  Eur J Nuerosci. 19 (10) 2682 - 2692 2017 [Refereed]
  
• Corrigendum: Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior.

  Jung D; Hwang YJ; Ryu H; Kano M; Sakimura K; Cho J

  Frontiers in behavioral neuroscience 11 242  2017 [Refereed]
  
• Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease

  Masanobu Kano; Takaki Watanabe

  F1000Research Faculty of 1000 Ltd 6 416  1759-796X 2017 [Refereed]
  
• Consensus Paper: Cerebellar Development

  Ketty Leto; Marife Arancillo; Esther B. E. Becker; Annalisa Buffo; Chin Chiang; Baojin Ding; William B. Dobyns; Isabelle Dusart; Parthiv Haldipur; Mary E. Hatten; Mikio Hoshino; Alexandra L. Joyner; Masanobu Kano; Daniel L. Kilpatrick; Noriyuki Koibuchi; Silvia Marino; Salvador Martinez; Kathleen J. Millen; Thomas O. Millner; Takaki Miyata; Elena Parmigiani; Karl Schilling; Gabriella Sekerkova; Roy V. Sillitoe; Constantino Sotelo; Naofumi Uesaka; Annika Wefers; Richard J. T. Wingate; Richard Hawkes

  CEREBELLUM SPRINGER 15 (6) 789 - 828 1473-4222 2016/12 [Refereed]
  
• Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior

  Dahee Jung; Yu J. Hwang; Hoon Ryu; Masanobu Kano; Kenji Sakimura; Jeiwon Cho

  FRONTIERS IN BEHAVIORAL NEUROSCIENCE FRONTIERS MEDIA SA 10 214  1662-5153 2016/11 [Refereed]
  
• LTD-like molecular pathways in developmental synaptic pruning

  Claire Piochon; Masanobu Kano; Christian Hansel

  NATURE NEUROSCIENCE NATURE PUBLISHING GROUP 19 (10) 1299 - 1310 1097-6256 2016/10 [Refereed]
  
• Inhibition promotes long-term potentiation at cerebellar excitatory synapses

  F. Binda; K. Dorgans; S. Reibel; K. Sakimura; M. Kano; B. Poulain; P. Isope

  SCIENTIFIC REPORTS NATURE PUBLISHING GROUP 6 33561  2045-2322 2016/09 [Refereed]
  
• The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus

  Madoka Narushima; Motokazu Uchigashima; Yuki Yagasaki; Takeshi Harada; Yasuyuki Nagumo; Naofumi Uesaka; Kouichi Hashimoto; Atsu Aiba; Masahiko Watanabe; Mariko Miyata; Masanobu Kano

  NEURON CELL PRESS 91 (5) 1097 - 1109 0896-6273 2016/09 [Refereed]
  
• Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum

  Matasha Dhar; Joshua M. Brenner; Kenji Sakimura; Masanobu Kano; Hiroshi Nishiyama

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 7 12938  2041-1723 2016/09 [Refereed]
  
• Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures

  Yuki Sugaya; Maya Yamazaki; Motokazu Uchigashima; Kenta Kobayashi; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano

  CELL REPORTS CELL PRESS 16 (5) 1405 - 1415 2211-1247 2016/08 [Refereed]
  
• Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive

  Yoshiko Matsumoto-Makidono; Hisako Nakayama; Miwako Yamasaki; Taisuke Miyazaki; Kazuto Kobayashi; Masahiko Watanabe; Masanobu Kano; Kenji Sakimura; Kouichi Hashimoto

  CELL REPORTS CELL PRESS 16 (4) 994 - 1004 2211-1247 2016/07 [Refereed]
  
• SCN5A(K817E), a novel Brugada syndrome-associated mutation that alters the activation gating of Na(V)1.5 channel

  Koshi Kinoshita; Hiroyuki Takahashi; Yukiko Hata; Kohki Nishide; Mario Kato; Hiroki Fujita; Sho Yoshida; Kazutaka Murai; Koichi Mizumaki; Kunihiro Nishida; Yoshiaki Yamaguchi; Masanobu Kano; Toshihide Tabata; Naoki Nishida

  HEART RHYTHM ELSEVIER SCIENCE INC 13 (5) 1113 - 1120 1547-5271 2016/05 [Refereed]
  
• Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins

  Keiko Matsuda; Timotheus Budisantoso; Nikolaos Mitakidis; Yuki Sugaya; Eriko Miura; Wataru Kakegawa; Miwako Yamasaki; Kohtarou Konno; Motokazu Uchigashima; Manabu Abe; Izumi Watanabe; Masanobu Kano; Masahiko Watanabe; Kenji Sakimura; A. Radu Aricescu; Michisuke Yuzaki

  NEURON CELL PRESS 90 (4) 752 - 767 0896-6273 2016/05 [Refereed]
  
• Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.

  Nakazawa T; Hashimoto R; Sakoori K; Sugaya Y; Tanimura A; Hashimotodani Y; Ohi K; Yamamori H; Yasuda Y; Umeda-Yano S; Kiyama Y; Konno K; Inoue T; Yokoyama K; Inoue T; Numata S; Ohnuma T; Iwata N; Ozaki N; Hashimoto H; Watanabe M; Manabe T; Yamamoto T; Takeda M; Kano M

  Nature communications 7 11466  2016/04 [Refereed]
  
• Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses

  Romain Ly; Guy Bouvier; German Szapiro; Haydn M. Prosser; Andrew D. Randall; Masanobu Kano; Kenji Sakimura; Philippe Isope; Boris Barbour; Anne Feltz

  JOURNAL OF PHYSIOLOGY-LONDON WILEY-BLACKWELL 594 (4) 915 - 936 0022-3751 2016/02 [Refereed]
  
• Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

  Takanobu Nakazawa; Ryota Hashimoto; Kazuto Sakoori; Yuki Sugaya; Asami Tanimura; Yuki Hashimotodani; Kazutaka Ohi; Hidenaga Yamamori; Yuka Yasuda; Satomi Umeda-Yano; Yuji Kiyama; Kohtarou Konno; Takeshi Inoue; Kazumasa Yokoyama; Takafumi Inoue; Shusuke Numata; Tohru Ohnuma; Nakao Iwata; Norio Ozaki; Hitoshi Hashimoto; Masahiko Watanabe; Toshiya Manabe; Tadashi Yamamoto; Masatoshi Takeda; Masanobu Kano

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 7 10594  2041-1723 2016/02 [Refereed]
  
• Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination

  Ryoichi Ichikawa; Kouichi Hashimoto; Taisuke Miyazaki; Motokazu Uchigashima; Miwako Yamasaki; Atsu Aiba; Masanobu Kano; Masahiko Watanabe

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 113 (8) 2282 - 2287 0027-8424 2016/02 [Refereed]
  
• Genetic inactivation and prolonged pharmacologic inhibition of monoacylglycerol lipase have opposite effects on anesthetic sensitivity to propofol

  Andrey B. Petrenko; Maya Yamazaki; Kenji Sakimura; Masanobu Kano; Hiroshi Baba

  EUROPEAN JOURNAL OF PHARMACOLOGY ELSEVIER SCIENCE BV 765 268 - 273 0014-2999 2015/10 [Refereed]
  
• Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E-2

  Yoshihiro Kita; Kenij Yoshida; Suzumi M. Tokuoka; Fumie Hamano; Maya Yamazaki; Kenji Sakimura; Masanobu Kano; Takao Shimizu

  PLOS ONE PUBLIC LIBRARY SCIENCE 10 (7) e0133663  1932-6203 2015/07 [Refereed]
  
• Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice

  Tomomi Aida; Junichi Yoshida; Masatoshi Nomura; Asami Tanimura; Yusuke Iino; Miho Soma; Ning Bai; Yukiko Ito; Wanpeng Cui; Hidenori Aizawa; Michiko Yanagisawa; Terumi Nagai; Norio Takata; Kenji F. Tanaka; Ryoichi Takayanagi; Masanobu Kano; Magdalena Goetz; Hajime Hirase; Kohichi Tanaka

  NEUROPSYCHOPHARMACOLOGY NATURE PUBLISHING GROUP 40 (7) 1569 - 1579 0893-133X 2015/06 [Refereed]
  
• Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy (vol 16, pg 264, 2015)

  Ivan Soltesz; Bradley E. Alger; Masanobu Kano; Sang-Hun Lee; David M. Lovinger; Takako Ohno-Shosaku; Masahiko Watanabe

  NATURE REVIEWS NEUROSCIENCE NATURE PUBLISHING GROUP 16 (6) 264 - 277 1471-003X 2015/06 [Refereed]
  
• Implicit Memory in Monkeys: Development of a Delay Eyeblink Conditioning System with Parallel Electromyographic and High-Speed Video Measurements

  Yasushi Kishimoto; Shigeyuki Yamamoto; Kazutaka Suzuki; Haruyoshi Toyoda; Masanobu Kano; Hideo Tsukada; Yutaka Kirino

  PLOS ONE PUBLIC LIBRARY SCIENCE 10 (6) e0129828  1932-6203 2015/06 [Refereed]
  
• Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol

  Yasushi Kishimoto; Barbara Cagniard; Maya Yamazaki; Junko Nakayama; Kenji Sakimura; Yutaka Kirino; Masanobu Kano

  FRONTIERS IN BEHAVIORAL NEUROSCIENCE FRONTIERS RESEARCH FOUNDATION 9 134  1662-5153 2015/06 [Refereed]
  
• The Susceptibilities of Human Ether-a-Go-Go-Related Gene Channel with the G487R Mutation to Arrhythmogenic Factors

  Nozomi Hisajima; Yukiko Hata; Koshi Kinoshita; Toshiki Fukushima; Naoki Nishida; Masanobu Kano; Toshihide Tabata

  BIOLOGICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 38 (5) 781 - 784 0918-6158 2015/05 [Refereed]
  
• Retrograde Signaling for Climbing Fiber Synapse Elimination

  Naofumi Uesaka; Motokazu Uchigashima; Takayasu Mikuni; Hirokazu Hirai; Masahiko Watanabe; Masanobu Kano

  CEREBELLUM SPRINGER 14 (1) 4 - 7 1473-4222 2015/02 [Refereed]
  
• Corrigendum: Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism.

  Piochon C; Kloth AD; Grasselli G; Titley HK; Nakayama H; Hashimoto K; Wan V; Simmons DH; Eissa T; Nakatani J; Cherskov A; Miyazaki T; Watanabe M; Takumi T; Kano M; Wang SS; Hansel C

  Nature communications 6 6014  2015/01 [Refereed]
  
• Rational design of a high-affinity, fast, red calcium indicator R-CaMP2

  Masatoshi Inoue; Atsuya Takeuchi; Shin-ichiro Horigane; Masamichi Ohkura; Keiko Gengyo-Ando; Hajime Fujii; Satoshi Kamijo; Sayaka Takemoto-Kimura; Masanobu Kano; Junichi Nakai; Kazuo Kitamura; Haruhiko Bito

  NATURE METHODS NATURE PUBLISHING GROUP 12 (1) 64 - 70 1548-7091 2015/01 [Refereed]
  
• Structure-Function Relationships between Aldolase C/Zebrin II Expression and Complex Spike Synchrony in the Cerebellum

  Shinichiro Tsutsumi; Maya Yamazaki; Taisuke Miyazaki; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano; Kazuo Kitamura

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 35 (2) 843 - 852 0270-6474 2015/01 [Refereed]
  
• Endocannabinoid-mediated retrograde modulation of synaptic transmission

  Takako Ohno-Shosaku; Masanobu Kano

  CURRENT OPINION IN NEUROBIOLOGY CURRENT BIOLOGY LTD 29 1 - 8 0959-4388 2014/12 [Refereed]
  
• Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism

  Claire Piochon; Alexander D. Kloth; Giorgio Grasselli; Heather K. Titley; Hisako Nakayama; Kouichi Hashimoto; Vivian Wan; Dana H. Simmons; Tahra Eissa; Jin Nakatani; Adriana Cherskov; Taisuke Miyazaki; Masahiko Watanabe; Toru Takumi; Masanobu Kano; Samuel S. -H. Wang; Christian Hansel

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 5 5586  2041-1723 2014/11 [Refereed]
  
• Neural circuits: Japan

  Yasuo Kawaguchi; Masanobu Kano

  FRONTIERS IN NEURAL CIRCUITS FRONTIERS RESEARCH FOUNDATION 8 135  1662-5110 2014/11 [Refereed]
  
• Activity-Dependent Gating of Calcium Spikes by A-type K plus Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites

  Yo Otsu; Paikan Marcaggi; Anne Feltz; Philippe Isope; Mihaly Kollo; Zoltan Nusser; Benjamin Mathieu; Masanobu Kano; Mika Tsujita; Kenji Sakimura; Stephane Dieudonne

  NEURON CELL PRESS 84 (1) 137 - 151 0896-6273 2014/10 [Refereed]
  
• Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol

  Audrey B. Petrenko; Maya Yamazaki; Kenji Sakimura; Masanobu Kano; Hiroshi Baba

  BEHAVIOURAL BRAIN RESEARCH ELSEVIER SCIENCE BV 271 51 - 58 0166-4328 2014/09 [Refereed]
  
• Global Scaling Down of Excitatory Postsynaptic Responses in Cerebellar Purkinje Cells Impairs Developmental Synapse Elimination

  Shinya Kawata; Taisuke Miyazaki; Maya Yamazaki; Takayasu Mikuni; Miwako Yamasaki; Kouichi Hashimoto; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano

  CELL REPORTS CELL PRESS 8 (4) 1119 - 1129 2211-1247 2014/08 [Refereed]
  
• Control of synaptic function by endocannabinoid-mediated retrograde signaling

  Masanobu Kano

  PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES JAPAN ACAD 90 (7) 235 - 250 0386-2208 2014/07 [Refereed]
  
• A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo

  Mayumi Tada; Atsuya Takeuchi; Miki Hashizume; Kazuo Kitamura; Masanobu Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE WILEY-BLACKWELL 39 (11) 1720 - 1728 0953-816X 2014/06 [Refereed]
  
• Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases

  Hidetoshi Kassai; Yuki Sugaya; Shoko Noda; Kazuki Nakao; Tatsuya Maeda; Masanobu Kano; Atsu Aiba

  CELL REPORTS CELL PRESS 7 (5) 1626 - 1639 2211-1247 2014/06 [Refereed]
  
• Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain

  Naofumi Uesaka; Motokazu Uchigashima; Takayasu Mikuni; Takanobu Nakazawa; Harumi Nakao; Hirokazu Hirai; Atsu Aiba; Masahiko Watanabe; Masanobu Kano

  SCIENCE AMER ASSOC ADVANCEMENT SCIENCE 344 (6187) 1020 - 1023 0036-8075 2014/05 [Refereed]
  
• Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord

  Eszter Horvath; Stephen G. Woodhams; Rita Nyilas; Christopher M. Henstridge; Masanobu Kano; Kenji Sakimura; Masahiko Watanabe; Istvan Katona

  EUROPEAN JOURNAL OF NEUROSCIENCE WILEY-BLACKWELL 39 (3) 419 - 434 0953-816X 2014/02 [Refereed]
  
• The Synaptic Targeting of mGluR1 by Its Carboxyl-Terminal Domain Is Crucial for Cerebellar Function

  Yoshiaki Ohtani; Mariko Miyata; Kouichi Hashimoto; Toshihide Tabata; Yasushi Kishimoto; Masahiro Fukaya; Daisuke Kase; Hidetoshi Kassai; Kazuki Nakao; Tatsumi Hirata; Masahiko Watanabe; Masanobu Kano; Atsu Aiba

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 34 (7) 2702 - 2712 0270-6474 2014/02 [Refereed]
  
• Synapse elimination in the developing cerebellum

  Kouichi Hashimoto; Masanobu Kano

  CELLULAR AND MOLECULAR LIFE SCIENCES SPRINGER BASEL AG 70 (24) 4667 - 4680 1420-682X 2013/12 [Refereed]
  
• Dendritic calcium signaling in cerebellar Purkinje cell

  Kazuo Kitamura; Masanobu Kano

  NEURAL NETWORKS PERGAMON-ELSEVIER SCIENCE LTD 47 11 - 17 0893-6080 2013/11 [Refereed]
  
• Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development

  Yoshinobu Kawamura; Hisako Nakayama; Kouichi Hashimoto; Kenji Sakimura; Kazuo Kitamura; Masanobu Kano

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 4 2732  2041-1723 2013/11 [Refereed]
  
• Functional Cooperation of Metabotropic Adenosine and Glutamate Receptors Regulates Postsynaptic Plasticity in the Cerebellum

  Yuji Kamikubo; Takeshi Shimomura; Yosuke Fujita; Toshihide Tabata; Taku Kashiyama; Takashi Sakurai; Kenkichi Fukurotani; Masanobu Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 33 (47) 18661 - 18671 0270-6474 2013/11 [Refereed]
  
• Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: Evidence for on-demand biosynthesis of 2-arachidonoylglycerol

  Yuki Hashimotodani; Takako Ohno-Shosaku; Asami Tanimura; Yoshihiro Kita; Yoshikazu Sano; Takao Shimizu; Vincenzo Di Marzo; Masanobu Kano

  Journal of Physiology 591 (19) 4765 - 4776 0022-3751 2013/10 [Refereed]
  
• Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE

  Takashi Kawashima; Kazuo Kitamura; Kanzo Suzuki; Mio Nonaka; Satoshi Kamijo; Sayaka Takemoto-Kimura; Masanobu Kano; Hiroyuki Okuno; Kenichi Ohki; Haruhiko Bito

  NATURE METHODS NATURE PUBLISHING GROUP 10 (9) 889 - + 1548-7091 2013/09 [Refereed]
  
• Disruption of cerebellar microzonal organization in GluD2 (GluR delta 2) knockout mouse

  Miki Hashizume; Taisuke Miyazaki; Kenji Sakimura; Masahiko Watanabe; Kazuo Kitamura; Masanobu Kano

  FRONTIERS IN NEURAL CIRCUITS FRONTIERS RESEARCH FOUNDATION 7 130  1662-5110 2013/08 [Refereed]
  
• Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development

  Masanobu Kano; Hisako Nakayama; Kouichi Hashimoto; Kazuo Kitamura; Kenji Sakimura; Masahiko Watanabe

  JOURNAL OF PHYSIOLOGY-LONDON WILEY-BLACKWELL 591 (13) 3151 - 3158 0022-3751 2013/07 [Refereed]
  
• Diacylglycerol lipase a manipulation reveals developmental roles for intercellular endocannabinoid signaling

  Erik Keimpema; Alan Alpar; Fiona Howell; Katarzyna Malenczyk; Carl Hobbs; Yasmin L. Hurd; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano; Patrick Doherty; Tibor Harkany

  Scientific Reports Nature Publishing Group 3 2093  2045-2322 2013/06 [Refereed]
  
• Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits

  Naosuke Hoshina; Asami Tanimura; Miwako Yamasaki; Takeshi Inoue; Ryoji Fukabori; Teiko Kuroda; Kazumasa Yokoyama; Tohru Tezuka; Hiroshi Sagara; Shinji Hirano; Hiroshi Kiyonari; Masahiko Takada; Kazuto Kobayashi; Masahiko Watanabe; Masanobu Kano; Takanobu Nakazawa; Tadashi Yamamoto

  NEURON CELL PRESS 78 (5) 839 - 854 0896-6273 2013/06 [Refereed]
  
• Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum

  Takayasu Mikuni; Naofumi Uesaka; Hiroyuki Okuno; Hirokazu Hirai; Karl Deisseroth; Haruhiko Bito; Masanobu Kano

  NEURON CELL PRESS 78 (6) 1024 - 1035 0896-6273 2013/06 [Refereed]
  
• Nonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKII alpha and Calcineurin

  Hajime Fujii; Masatoshi Inoue; Hiroyuki Okuno; Yoshikazu Sano; Sayaka Takemoto-Kimura; Kazuo Kitamura; Masanobu Kano; Haruhiko Bito

  CELL REPORTS CELL PRESS 3 (4) 978 - 987 2211-1247 2013/04 [Refereed]
  
• The Endocannabinoid 2-Arachidonoylglycerol Negatively Regulates Habituation by Suppressing Excitatory Recurrent Network Activity and Reducing Long-Term Potentiation in the Dentate Gyrus

  Yuki Sugaya; Barbara Cagniard; Maya Yamazaki; Kenji Sakimura; Masanobu Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 33 (8) 3588 - 3601 0270-6474 2013/02 [Refereed]
  
• Difference in synaptic strengths among competing inputs and absolute synaptic strengths contribute to distinct phase of climbing fiber synapse development in cerebellum

  Kawata Shinya; Hashimoto Kouichi; Yamazaki Maya; Miyazaki Taisuke; Yamasaki Miwako; Mikuni Takayasu; Watanabe Masahiko; Sakimura Kenji; Kano Masanobu

  JOURNAL OF PHYSIOLOGICAL SCIENCES 63 S188  1880-6546 2013 [Refereed]
  
• Spatiotemporal Dynamics of Functional Clusters of Neurons in the Mouse Motor Cortex during a Voluntary Movement

  Riichiro Hira; Fuki Ohkubo; Katsuya Ozawa; Yoshikazu Isomura; Kazuo Kitamura; Masanobu Kano; Haruo Kasai; Masanori Matsuzaki

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 33 (4) 1377 - 1390 0270-6474 2013/01 [Refereed]
  
• Organotypic Coculture Preparation for the Study of Developmental Synapse Elimination in Mammalian Brain

  Naofumi Uesaka; Takayasu Mikuni; Kouichi Hashimoto; Hirokazu Hirai; Kenji Sakimura; Masanobu Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 32 (34) 11657 - 11670 0270-6474 2012/08 [Refereed]
  
• Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression

  Asami Tanimura; Motokazu Uchigashima; Maya Yamazaki; Naofumi Uesaka; Takayasu Mikuni; Manabu Abe; Kouichi Hashimoto; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 109 (30) 12195 - 12200 0027-8424 2012/07 [Refereed]
  
• Activity-Dependent Maturation of Climbing Fiber to Purkinje Cell Synapses during Postnatal Cerebellar Development

  Masanobu Kano; Kouichi Hashimoto

  CEREBELLUM SPRINGER 11 (2) 449 - 450 1473-4222 2012/06 [Refereed]
  
• Endocannabinoids and Retrograde Modulation of Synaptic Transmission

  Takako Ohno-Shosaku; Asami Tanimura; Yuki Hashimotodani; Masanobu Kano

  NEUROSCIENTIST SAGE PUBLICATIONS INC 18 (2) 119 - 132 1073-8584 2012/04 [Refereed]
  
• The p250GAP Gene Is Associated with Risk for Schizophrenia and Schizotypal Personality Traits

  Kazutaka Ohi; Ryota Hashimoto; Takanobu Nakazawa; Takeya Okada; Yuka Yasuda; Hidenaga Yamamori; Motoyuki Fukumoto; Satomi Umeda-Yano; Masao Iwase; Hiroaki Kazui; Tadashi Yamamoto; Masanobu Kano; Masatoshi Takeda

  PLOS ONE PUBLIC LIBRARY SCIENCE 7 (4) e35696  1932-6203 2012/04 [Refereed]
  
• GABAergic Inhibition Regulates Developmental Synapse Elimination in the Cerebellum

  Hisako Nakayama; Taisuke Miyazaki; Kazuo Kitamura; Kouichi Hashimoto; Yuchio Yanagawa; Kunihiko Obata; Kenji Sakimura; Masahiko Watanabe; Masanobu Kano

  NEURON CELL PRESS 74 (2) 384 - 396 0896-6273 2012/04 [Refereed]
  
• Locally Synchronized Synaptic Inputs

  Naoya Takahashi; Kazuo Kitamura; Naoki Matsuo; Mark Mayford; Masanobu Kano; Norio Matsuki; Yuji Ikegaya

  SCIENCE AMER ASSOC ADVANCEMENT SCIENCE 335 (6066) 353 - 356 0036-8075 2012/01 [Refereed]
  
• Ca(v)2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring, Cell Survival, and Cerebellar Biochemical Compartmentalization

  Taisuke Miyazaki; Miwako Yamasaki; Kouichi Hashimoto; Maya Yamazaki; Manabu Abe; Hiroshi Usui; Masanobu Kano; Kenji Sakimura; Masahiko Watanabe

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 32 (4) 1311 - 1328 0270-6474 2012/01 [Refereed]
  
• Climbing fiber synapse elimination in cerebellar Purkinje cells

  Masahiko Watanabe; Masanobu Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE WILEY-BLACKWELL 34 (10) 1697 - 1710 0953-816X 2011/11 [Refereed]
  
• Developmental Switching of Perisomatic Innervation from Climbing Fibers to Basket Cell Fibers in Cerebellar Purkinje Cells

  Ryoichi Ichikawa; Miwako Yamasaki; Taisuke Miyazaki; Kohtarou Konno; Kouichi Hashimoto; Haruyuki Tatsumi; Yoshiro Inoue; Masanobu Kano; Masahiko Watanabe

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 31 (47) 16916 - 16927 0270-6474 2011/11 [Refereed]
  
• Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum

  Kouichi Hashimoto; Mika Tsujita; Taisuke Miyazaki; Kazuo Kitamura; Maya Yamazaki; Hee-Sup Shin; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 108 (24) 9987 - 9992 0027-8424 2011/06 [Refereed]
  
• In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice

  Jun Noguchi; Akira Nagaoka; Satoshi Watanabe; Graham C. R. Ellis-Davies; Kazuo Kitamura; Masanobu Kano; Masanori Matsuzaki; Haruo Kasai

  JOURNAL OF PHYSIOLOGY-LONDON WILEY-BLACKWELL 589 (10) 2447 - 2457 0022-3751 2011/05 [Refereed]
  
• Molecular and Morphological Configuration for 2-Arachidonoylglycerol-Mediated Retrograde Signaling at Mossy Cell-Granule Cell Synapses in the Dentate Gyrus

  Motokazu Uchigashima; Maya Yamazaki; Miwako Yamasaki; Asami Tanimura; Kenji Sakimura; Masanobu Kano; Masahiko Watanabe

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 31 (21) 7700 - 7714 0270-6474 2011/05 [Refereed]
  
• A Role for Myosin Va in Cerebellar Plasticity and Motor Learning: A Possible Mechanism Underlying Neurological Disorder in Myosin Va Disease

  Mariko Miyata; Yasushi Kishimoto; Masahiko Tanaka; Kouichi Hashimoto; Naohide Hirashima; Yoshiharu Murata; Masanobu Kano; Yoshiko Takagishi

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 31 (16) 6067 - 6078 0270-6474 2011/04 [Refereed]
  
• COMPLEMENTARY SYNAPTIC DISTRIBUTION OF ENZYMES RESPONSIBLE FOR SYNTHESIS AND INACTIVATION OF THE ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL IN THE HUMAN HIPPOCAMPUS

  A. Ludanyi; S. -J. Hu; M. Yamazaki; A. Tanimura; D. Piomelli; M. Watanabe; M. Kano; K. Sakimura; Z. Magloczky; K. Mackie; T. F. Freund; I. Katona

  NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD 174 50 - 63 0306-4522 2011/02 [Refereed]
  
• Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus

  Takayuki Yoshida; Motokazu Uchigashima; Miwako Yamasaki; Istvan Katona; Maya Yamazaki; Kenji Sakimura; Masanobu Kano; Mitsuhiro Yoshioka; Masahiko Watanabe

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 108 (7) 3059 - 3064 0027-8424 2011/02 [Refereed]
  
• Neuronal Protease-Activated Receptor 1 Drives Synaptic Retrograde Signaling Mediated by the Endocannabinoid 2-Arachidonoylglycerol

  Yuki Hashimotodani; Takako Ohno-Shosaku; Maya Yamazaki; Kenji Sakimura; Masanobu Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 31 (8) 3104 - 3109 0270-6474 2011/02 [Refereed]
  
• Glutamate transporter GLAST is essential for cytodifferentiation of Bergmann glia and maintenance of excitatory synaptic wiring in the cerebellum

  Taisuke Miyazaki; Miwako Yamasaki; Kouichi Hashimoto; Keiko Shimamoto; Kazuhisa Kohda; Michisuke Yuzaki; Kohichi Tanaka; Masanobu Kano; Masahiko Watanabe

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 71 E63 - E63 0168-0102 2011 [Refereed]
  
• Invaginating inhibitory synapse with particularly rich endocannabinoid signaling machinery in the basal nucleus of the amygdala

  Yoshida Takayuki; Uchigashima Motokazu; Yamasaki Miwako; Katona Istvan; Yamazaki Maya; Sakimura Kenji; Kano Masanobu; Yoshioka Mitsuhiro; Watanabe Masahiko

  NEUROSCIENCE RESEARCH 71 E93 - E94 0168-0102 2011 [Refereed]
  
• TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum

  Maya Yamazaki; Masahiro Fukaya; Kouichi Hashimoto; Miwako Yamasaki; Mika Tsujita; Makoto Itakura; Manabu Abe; Rie Natsume; Masami Takahashi; Masanobu Kano; Kenji Sakimura; Masahiko Watanabe

  EUROPEAN JOURNAL OF NEUROSCIENCE WILEY-BLACKWELL 31 (12) 2204 - 2220 0953-816X 2010/06 [Refereed]
  
• A new multiple-drug applicator with minimal drug cross-talk, leakage, and consumption

  Yosuke Fujita; Takeshi Shimomura; Masafumi Hosoguchi; Masanobu Kano; Kenkichi Fukurotani; Toshihide Tabata

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 66 (4) 412 - 414 0168-0102 2010/04 [Refereed]
  
• Role of pre- and postsynaptic activity in thalamocortical axon branching

  Akito Yamada; Naofumi Uesaka; Yasufumi Hayano; Toshihide Tabata; Masanobu Kano; Nobuhiko Yamamoto

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 107 (16) 7562 - 7567 0027-8424 2010/04 [Refereed]
  
• The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase alpha Mediates Retrograde Suppression of Synaptic Transmission

  Asami Tanimura; Maya Yamazaki; Yuki Hashimotodani; Motokazu Uchigashima; Shinya Kawata; Manabu Abe; Yoshihiro Kita; Kouichi Hashimoto; Takao Shimizu; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano

  NEURON CELL PRESS 65 (3) 320 - 327 0896-6273 2010/02 [Refereed]
  
• TARPs gamma-2 and gamma-7 are functional components of cerebellar AMPA receptor

  Yamazaki Maya; Fukaya Masahiro; Hashimoto Kouichi; Yamasaki Miwako; Itakura Makoto; Takahashi Masami; Kano Masanobu; Watanabe Masahiko; Sakimura Kenji

  NEUROSCIENCE RESEARCH 68 E223 - E224 0168-0102 2010 [Refereed]
  
• P/Q type voltage dependent Ca2+ channel is crucial for early postnatal development of climbing fiber to Purkinje cell synapse

  Hashimoto Kouichi; Tsujita Mika; Kitamura Kazuo; Miyazaki Taisuke; Yamazaki Maya; Shin Hee-Sup; Watanabe Masahiko; Sakimura Kenji; Kano Masanobu

  NEUROSCIENCE RESEARCH 68 E37 - E38 0168-0102 2010 [Refereed]
  
• Angiotensin Receptor Blocker Prevented beta-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

  Shuko Takeda; Naoyuki Sato; Daisuke Takeuchi; Hitomi Kurinami; Mitsuru Shinohara; Kazue Niisato; Masanobu Kano; Toshio Ogihara; Hiromi Rakugi; Ryuichi Morishita

  HYPERTENSION LIPPINCOTT WILLIAMS & WILKINS 54 (6) 1345 - U125 0194-911X 2009/12 [Refereed]
  
• Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

  Sachiko Taniguchi; Takanobu Nakazawa; Asami Tanimura; Yuji Kiyama; Tohru Tezuka; Ayako M. Watabe; Norikazu Katayama; Kazumasa Yokoyama; Takeshi Inoue; Hiroko Izumi-Nakaseko; Shigeru Kakuta; Katsuko Sudo; Yoichiro Iwakura; Hisashi Umemori; Takafumi Inoue; Niall P. Murphy; Kouichi Hashimoto; Masanobu Kano; Toshiya Manabe; Tadashi Yamamoto

  EMBO JOURNAL JOHN WILEY & SONS LTD 28 (23) 3717 - 3729 0261-4189 2009/12 [Refereed]
  
• INFLUENCE OF PARALLEL FIBER-PURKINJE CELL SYNAPSE FORMATION ON POSTNATAL DEVELOPMENT OF CLIMBING FIBER-PURKINJE CELL SYNAPSES IN THE CEREBELLUM

  K. Hashimoto; T. Yoshida; K. Sakimura; M. Mishina; M. Watanabe; M. Kano

  NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD 162 (3) 601 - 611 0306-4522 2009/09 [Refereed]
  
• Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents

  Asami Tanimura; Shinya Kawata; Kouichi Hashimoto; Masanobu Kano

  NEUROPHARMACOLOGY PERGAMON-ELSEVIER SCIENCE LTD 57 (2) 157 - 163 0028-3908 2009/08 [Refereed]
  
• Functional Coupling between mGluR1 and Ca(v)3.1 T-Type Calcium Channels Contributes to Parallel Fiber-Induced Fast Calcium Signaling within Purkinje Cell Dendritic Spines

  Michael E. Hildebrand; Philippe Isope; Taisuke Miyazaki; Toshitaka Nakaya; Esperanza Garcia; Anne Feltz; Toni Schneider; Juergen Hescheler; Masanobu Kano; Kenji Sakimura; Masahiko Watanabe; Stephane Dieudonne; Terrance P. Snutch

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 29 (31) 9668 - 9682 0270-6474 2009/08 [Refereed]
  
• Validation of A beta 1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease

  Shuko Takeda; Naoyuki Sato; Kazue Niisato; Daisuke Takeuchi; Hitomi Kurinami; Mitsuru Shinohara; Hiromi Rakugi; Masanobu Kano; Ryuichi Morishita

  BRAIN RESEARCH ELSEVIER SCIENCE BV 1280 137 - 147 0006-8993 2009/07 [Refereed]
  
• Translocation of a "Winner" Climbing Fiber to the Purkinje Cell Dendrite and Subsequent Elimination of "Losers" from the Soma in Developing Cerebellum

  Kouichi Hashimoto; Ryoichi Ichikawa; Kazuo Kitamura; Masahiko Watanabe; Masanobu Kano

  NEURON CELL PRESS 63 (1) 106 - 118 0896-6273 2009/07 [Refereed]
  
• Synapse elimination in the central nervous system

  Masanobu Kano; Kouichi Hashimoto

  CURRENT OPINION IN NEUROBIOLOGY CURRENT BIOLOGY LTD 19 (2) 154 - 161 0959-4388 2009/04 [Refereed]
  
• Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice

  Toshiya Sato; Masami Miura; Mitsunori Yamada; Takayuki Yoshida; Jonathan D. Wood; Ikuru Yazawa; Masao Masuda; Takeo Suzuki; Ryong-Moon Shin; Hau-Jie Yau; Fu-Chin Liu; Takayoshi Shimohata; Osamu Onodera; Christopher A. Ross; Motoya Katsuki; Hitoshi Takahashi; Masanobu Kano; Toshihiko Aosaki; Shoji Tsuji

  HUMAN MOLECULAR GENETICS OXFORD UNIV PRESS 18 (4) 723 - 736 0964-6906 2009/02 [Refereed]
  
• Endocannabinoid-Mediated Control of Synaptic Transmission

  Masanobu Kano; Takako Ohno-Shosaku; Yuki Hashimotodani; Motokazu Uchigashima; Masahiko Watanabe

  PHYSIOLOGICAL REVIEWS AMER PHYSIOLOGICAL SOC 89 (1) 309 - 380 0031-9333 2009/01 [Refereed]
  
• Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination

  Masanobu Kano; Kouichi Hashimoto; Toshihide Tabata

  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES ROYAL SOC 363 (1500) 2173 - 2186 0962-8436 2008/06 [Refereed]
  
• Roles of metabotropic glutamate receptor subtype-1 in the adult cerebellum

  Nakao Harumi; Hashimoto Kouichi; Yamasaki Miwako; Nakao Kazuki; Watanabe Masahiko; Kano Masanobu; Ailba Atsu

  NEUROSCIENCE RESEARCH 61 S147  0168-0102 2008
• ERK is required for developmental synapse elimination in the cerebellum

  Takeshi Harada; Yoshie Hirai; Miwako Yamasaki; Kouichi Hashimoto; Harumi Nakao; Toshihide Tabata; Masahiko Watanabe; Masanobu Kano; Atsu Aiba

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 61 S57 - S57 0168-0102 2008 [Refereed]
  
• Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release

  Yuki Hashimotodani; Takako Ohno-Shosaku; Takashi Maejima; Kiyoko Fukami; Masanobu Kano

  NEUROPHARMACOLOGY PERGAMON-ELSEVIER SCIENCE LTD 54 (1) 58 - 67 0028-3908 2008/01 [Refereed]
  
• Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo

  Kazuo Kitamura; Benjamin Judkewitz; Masanobu Kano; Winfried Denk; Michael Hausser

  NATURE METHODS NATURE PUBLISHING GROUP 5 (1) 61 - 67 1548-7091 2008/01 [Refereed]
  
• Postsynaptic GABA(B) receptor signalling enhances LTD in mouse cerebellar Purkinje cells

  Yuji Kamikubo; Toshihide Tabata; Sho Kakizawa; Daisuke Kawakami; Masahiko Watanabe; Akihiko Ogura; Masamitsu Iino; Masanobu Kano

  JOURNAL OF PHYSIOLOGY-LONDON BLACKWELL PUBLISHING 585 (2) 549 - 563 0022-3751 2007/12 [Refereed]
  
• Endocannabinoid signalling triggered by NMDA receptor-mediated calcium entry into rat hippocampal neurons

  Takako Ohno-Shosaku; Yuki Hashimotodani; Masato Ano; Sachi Takeda; Hiroshi Tsubokawa; Masanobu Kano

  JOURNAL OF PHYSIOLOGY-LONDON BLACKWELL PUBLISHING 584 (2) 407 - 418 0022-3751 2007/10 [Refereed]
  
• Roles of phospholipase C beta and NMDA receptor in activity-dependent endocannabinoid release

  Yuki Hashimotodani; Takako Ohno-Shosaku; Masahiko Watanabe; Masanobu Kano

  JOURNAL OF PHYSIOLOGY-LONDON BLACKWELL PUBLISHING 584 (2) 373 - 380 0022-3751 2007/10 [Refereed]
  
• Conditioned eyebilink learning is formed and stored without cerebellar granule cell transmission

  Norio Wada; Yasushi Kishimoto; Dai Watanabe; Masanobu Kano; Tomoo Hirano; Kazuo Funabiki; Shigetada Nakanishi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 104 (42) 16690 - 16695 0027-8424 2007/10 [Refereed]
  
• Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression

  Shin-ichiro Kina; Tohru Tezuka; Shinji Kusakawa; Yasushi Kishimoto; Sho Kakizawa; Koichi Hashimoto; Miho Ohsugi; Yuji Kiyama; Reiko Horai; Katsuko Sudo; Shigeru Kakuta; Yoichiro Iwakura; Masamitsu Iino; Masanobu Kano; Toshiya Manabe; Tadashi Yamamoto

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING 26 (8) 2269 - 2278 0953-816X 2007/10 [Refereed]
  
• Motor discoordination of transgenic mice overexpressing a microtubule destabilizer, stathmin, specifically in Purkinje cells

  Noriaki Ohkawa; Kouichi Hashimoto; Toshiaki Hino; Rika Migishima; Minesuke Yokoyama; Masanobu Kano; Kaoru Inokuchi

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 59 (1) 93 - 100 0168-0102 2007/09 [Refereed]
  
• G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells

  Toshihide Tabata; Daisuke Kawakami; Kouichi Hashimoto; Hidetoshi Kassai; Takayuki Yoshida; Yuki Hashimotodani; Bertil B. Fredholm; Yuko Sekino; Atsu Aiba; Masanobu Kano

  JOURNAL OF PHYSIOLOGY-LONDON WILEY-BLACKWELL PUBLISHING, INC 581 (2) 693 - 708 0022-3751 2007/06 [Refereed]
  
• Ca2+-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities

  Yuki Hashimotodani; Takako Ohno-Shosaku; Masanobu Kano

  CURRENT OPINION IN NEUROBIOLOGY CURRENT BIOLOGY LTD 17 (3) 360 - 365 0959-4388 2007/06 [Refereed]
  
• Diminished climbing fiber innervation of purkinje cells in the cerebellum of myosin Va mutant mice and rats

  Yoshiko Takagishi; Kouichi Hashimoto; Tetsuro Kayahara; Masahiko Watanabe; Hiroyuki Otsuka; Akira Mizoguchi; Masanobu Kano; Yoshiharu Murata

  DEVELOPMENTAL NEUROBIOLOGY JOHN WILEY & SONS INC 67 (7) 909 - 923 1932-8451 2007/06 [Refereed]
  
• Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum

  Harumi Nakao; Kazuki Nakao; Masanobu Kano; Atsu Aiba

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 57 (4) 538 - 543 0168-0102 2007/04 [Refereed]
  
• Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity

  Sho Kakizawa; Yasushi Kishimoto; Kouichi Hashimoto; Taisuke Miyazaki; Kazuharu Furutani; Hidemi Shimizu; Masahiro Fukaya; Miyuki Nishi; Hiroyuki Sakagami; Atsushi Ikeda; Hisatake Kondo; Masanobu Kano; Masahiko Watanabe; Masamitsu Iino; Hiroshi Takeshima

  EMBO JOURNAL NATURE PUBLISHING GROUP 26 (7) 1924 - 1933 0261-4189 2007/04 [Refereed]
  
• Endocannabinoids and synaptic function in the CNS

  Yuki Hashimotodani; Takako Ohno-Shosaku; Masanobu Kano

  NEUROSCIENTIST SAGE PUBLICATIONS INC 13 (2) 127 - 137 1073-8584 2007/04 [Refereed]
  
• Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum

  Motokazu Uchigashima; Madoka Narushima; Masahiro Fukaya; Istvan Katona; Masanobu Kano; Masahiko Watanabe

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 27 (14) 3663 - 3676 0270-6474 2007/04 [Refereed]
  
• Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling in the striatum

  Motokazu Uchigashima; Madoka Narushima; Masahiro Fukaya; Istven Katona; Masanobu Kano; Masahiko Watanabe

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 58 S75 - S75 0168-0102 2007 [Refereed]
  
• Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum

  Madoka Narushima; Motokazu Uchigashima; Masahiro Fukaya; Minoru Matsui; Toshiya Manabe; Kouichi Hashimoto; Masahiko Watanabe; Masanobu Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 27 (3) 496 - 506 0270-6474 2007/01 [Refereed]
  
• Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus

  Yuki Hashimotodani; Takako Ohno-Shosaku; Masanobu Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 27 (5) 1211 - 1219 0270-6474 2007/01 [Refereed]
  
• Depolarization-induced suppression of inhibition mediated by endocannabinoids at synapses from fast-spiking interneurons to medium spiny neurons in the striatum

  Madoka Narushima; Motokazu Uchigashima; Kouichi Hashimoto; Masahiko Watanabe; Masanobu Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING 24 (8) 2246 - 2252 0953-816X 2006/10 [Refereed]
  
• Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites

  Masahiro Fukaya; Mika Tsujita; Maya Yamazaki; Etsuko Kushiya; Manabu Abe; Kaori Akashi; Rie Natsume; Masanobu Kano; Haruyuki Kamiya; Masahiko Watanabe; Kenji Sakimura

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING 24 (8) 2177 - 2190 0953-816X 2006/10 [Refereed]
  
• Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning

  Yasushi Kishimoto; Masanobu Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 26 (34) 8829 - 8837 0270-6474 2006/08 [Refereed]
  
• Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family

  Taisuke Miyazaki; Kouichi Hashimoto; Atsushi Uda; Hiroyuki Sakagami; Yoshitaka Nakamura; Shin-ya Saito; Miyuki Nishi; Hideaki Kume; Akira Tohgo; Izumi Kaneko; Hisatake Kondo; Kohji Fukunaga; Masanobu Kano; Masahiko Watanabe; Hiroshi Takeshima

  FEBS LETTERS ELSEVIER SCIENCE BV 580 (17) 4057 - 4064 0014-5793 2006/07 [Refereed]
  
• GABA(B) receptor-mediated modulation of glutamate signaling in cerebellar Purkinje cells

  Toshihide Tabata; Masanobu Kano

  CEREBELLUM TAYLOR & FRANCIS LTD 5 (2) 127 - 133 1473-4222 2006/06 [Refereed]
  
• Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor

  T Yoshida; M Fukaya; M Uchigashima; E Miura; H Kamiya; M Kano; M Watanabe

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 26 (18) 4740 - 4751 0270-6474 2006/05 [Refereed]
  
• Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum

  M Narushima; K Hashimoto; M Kano

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 54 (3) 159 - 164 0168-0102 2006/03 [Refereed]
  
• The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum

  Y Kawamura; M Fukaya; T Maejima; T Yoshida; E Miura; M Watanabe; T Ohno-Shosaku; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 26 (11) 2991 - 3001 0270-6474 2006/03 [Refereed]
  
• Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response

  Y Kishimoto; K Nakazawa; S Tonegawa; Y Kirino; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 26 (5) 1562 - 1570 0270-6474 2006/02 [Refereed]
  
• Morphological analysis of multiple climbing fiber innervation in PKC gamma-deficient mouse

  Yamasaki Miwako; Hashimoto Kouichi; Miyazaki Taisuke; Watanabe Masahiko; Kano Masanobu

  NEUROSCIENCE RESEARCH 55 S174  0168-0102 2006 [Refereed]
  
• Spine targeting of endocannabinoid synthesizing enzyme, diacylglycerol lipase-alpha in the cerebllum and hippocampus

  Takayuki Yoshida; Masahiro Fukaya; Motokazu Uchigashima; Eriko Miura; Haruyuki Kamiya; Masanobu Kano; Masahiko Watanabe

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 55 S77 - S77 0168-0102 2006 [Refereed]
  
• Distribution of TARP Gamma-8 on hippocampal neurons and its key role in synaptic and extrasynaptic expression for AMPA receptors

  Fukaya Masahiro; Tsujita Mika; Yamazaki Maya; Kushiya Etsuko; Abe Manabu; Akashi Kaori; Kano Masanobu; Kamiya Haruyuki; Sakimura Kenji; Watanabe Masahiko

  NEUROSCIENCE RESEARCH 55 S172  0168-0102 2006 [Refereed]
  
• Miniature synaptic events elicited by presynaptic Ca2+ rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells

  M Yamasaki; K Hashimoto; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 26 (1) 86 - 95 0270-6474 2006/01 [Refereed]
  
• Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain

  S Kakizawa; T Miyazaki; D Yanagihara; M Iino; M Watanabe; M Kano

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 102 (52) 19180 - 19185 0027-8424 2005/12 [Refereed]
  
• Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum

  K Hashimoto; M Kano

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 53 (3) 221 - 228 0168-0102 2005/11 [Refereed]
  
• Calcium signaling and synaptic modulation: Regulation of endocannabinoid-mediated synaptic modulation by calcium

  T Ohno-Shosaku; Y Hashimotodani; T Maejima; M Kano

  CELL CALCIUM CHURCHILL LIVINGSTONE 38 (3-4) 369 - 374 0143-4160 2005/09 [Refereed]
  
• Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase C beta 4 signaling cascade in the cerebellum

  T Maejima; S Oka; Y Hashimotodani; T Ohno-Shosaku; A Aiba; DQ Wu; K Waku; T Sugiura; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 25 (29) 6826 - 6835 0270-6474 2005/07 [Refereed]
  
• GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells

  T Tabata; S Haruki; H Nakayama; M Kano

  JOURNAL OF PHYSIOLOGY-LONDON WILEY 563 (2) 443 - 457 0022-3751 2005/03 [Refereed]
  
• Phospholipase C beta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal

  Y Hashimotodani; T Ohno-Shosaku; H Tsubokawa; H Ogata; K Emoto; T Maejima; K Araishi; HS Shin; M Kano

  NEURON CELL PRESS 45 (2) 257 - 268 0896-6273 2005/01 [Refereed]
  
• A novel action of stargazin as an enhancer of AMPA receptor activity

  M Yamazaki; T Ohno-Shosaku; M Fukaya; M Kano; M Watanabe; K Sakimura

  NEUROSCIENCE RESEARCH ELSEVIER SCI IRELAND LTD 50 (4) 369 - 374 0168-0102 2004/12 [Refereed]
  
• Signaling complex formation of phospholipase C beta 4 with metabotropic glutamate receptor type 1 alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain

  M Nakamura; K Sato; M Fukaya; K Araishi; A Aiba; M Kano; M Watanabe

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING LTD 20 (11) 2929 - 2944 0953-816X 2004/12 [Refereed]
  
• Ca2+ activity at GABA(B) receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA

  T Tabata; K Araishi; K Hashimoto; Y Hashimotodani; H van der Putten; B Bettler; M Kano

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 101 (48) 16952 - 16957 0027-8424 2004/11 [Refereed]
  
• Altered agonist sensitivity and desensitization of neuronal mGluR1 responses in knock-in mice by a single amino acid substitution at the PKC phosphorylation site

  M Sato; T Tabata; K Hashimoto; K Nakamura; K Nakao; M Katsuki; J Kitano; K Moriyoshi; M Kano; S Nakanishi

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING LTD 20 (4) 947 - 955 0953-816X 2004/08 [Refereed]
  
• Calcium dependence of native metabotropic glutamate receptor signaling in central neurons

  T Tabata; M Kano

  MOLECULAR NEUROBIOLOGY HUMANA PRESS INC 29 (3) 261 - 270 0893-7648 2004/06 [Refereed]
  
• Distinct roles of G alpha(q) and G alpha(11) for Purkinje cell signaling and motor behavior

  J Hartmann; R Blum; Y Kovalchuk; H Adelsberger; R Kuner; GM Durand; M Miyata; M Kano; S Offermanns; A Konnerth

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 24 (22) 5119 - 5130 0270-6474 2004/06 [Refereed]
  
• Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M-2-mediated direct suppression and M-1/M-3-mediated indirect suppression through endocannabinoid signalling

  Y Fukudome; T Ohno-Shosaku; M Matsui; Y Omori; M Fukaya; H Tsubokawa; MM Taketo; M Watanabe; T Manabe; M Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING LTD 19 (10) 2682 - 2692 0953-816X 2004/05 [Refereed]
  
• [Synaptic differentiation in the developing cerebellum]

  Hashimoto K; Kano M

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 3 Suppl 49 384 - 390 0039-9450 2004/02 [Refereed]
  
• ORP150/HSP12A regulates Purkinje cell survival: A role for endoplasmic reticulum stress in cerebellar development

  Y Kitao; K Hashimoto; T Matsuyama; H Iso; T Tamatani; O Hori; DM Stern; M Kano; K Ozawa; S Ogawa

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 24 (6) 1486 - 1496 0270-6474 2004/02 [Refereed]
  
• P/Q-type Ca2+ channel alpha 1A regulates synaptic competition on developing cerebellar Purkinje cells

  T Miyazaki; K Hashimoto; HS Shin; M Kano; M Watanabe

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 24 (7) 1734 - 1743 0270-6474 2004/02 [Refereed]
  
• Retrograde modulation of synaptic transmission mediated by endogenous cannabinoids

  M. Kano; T. Ohno-Shosaku; T. Maejima; T. Yoshida; K. Hashimoto

  Current Neuropharmacology 2 (1) 49 - 57 1570-159X 2004/01 [Refereed]
  
• Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup

  Y Takeda; K Akasaka; S Lee; S Kobayashi; H Kawano; S Murayama; N Takahashi; K Hashimoto; M Kano; M Asano; K Sudo; Y Iwakura; K Watanabe

  JOURNAL OF NEUROBIOLOGY JOHN WILEY & SONS INC 56 (3) 252 - 265 0022-3034 2003/09 [Refereed]
  
• Postsynaptic M-1 and M-3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus

  T Ohno-Shosaku; M Matsui; Y Fukudome; J Shosaku; H Tsubokawa; MM Taketo; T Manabe; M Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING LTD 18 (1) 109 - 116 0953-816X 2003/07 [Refereed]
  
• Functional differentiation of multiple climbing fiber inputs during synapse elimination in the developing cerebellum

  K Hashimoto; M Kano

  NEURON CELL PRESS 38 (5) 785 - 796 0896-6273 2003/06 [Refereed]
  
• Insulin-like growth factor-I as a promoting factor for cerebellar Purkinje cell development

  Y Fukudome; T Tabata; T Miyoshi; S Haruki; K Araishi; S Sawada; M Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING LTD 17 (10) 2006 - 2016 0953-816X 2003/05 [Refereed]
  
• Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar development

  S Kakizawa; K Yamada; M Iino; M Watanabe; M Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING LTD 17 (3) 545 - 554 0953-816X 2003/02 [Refereed]
  
• mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning

  Y Kishimoto; R Fujimichi; K Araishi; S Kawahara; M Kano; A Aiba; Y Kirino

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING LTD 16 (12) 2416 - 2424 0953-816X 2002/12 [Refereed]
  
• Group I metabotropic glutamate receptor signaling via G alpha q/G alpha 11 secures the induction of long-term potentiation in the hippocampal area CA1

  M Miura; M Watanabe; S Offermanns; MI Simon; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 22 (19) 8379 - 8390 0270-6474 2002/10 [Refereed]
  
• Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2

  R Ichikawa; T Miyazaki; M Kano; T Hashikawa; H Tatsumi; K Sakimura; M Mishina; Y Inoue; M Watanabe

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 22 (19) 8487 - 8503 0270-6474 2002/10 [Refereed]
  
• A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration

  K Watase; EJ Weeber; BS Xu; B Antalffy; L Yuva-Paylor; K Hashimoto; M Kano; R Atkinson; YL Sun; DL Armstrong; JD Sweatt; HT Orr; R Paylor; HY Zoghbi

  NEURON CELL PRESS 34 (6) 905 - 919 0896-6273 2002/06 [Refereed]
  
• Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses

  T Ohno-Shosaku; H Tsubokawa; Mizushima, I; N Yoneda; A Zimmer; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 22 (10) 3864 - 3872 0270-6474 2002/05 [Refereed]
  
• Extracellular calcium controls the dynamic range of neuronal metabotropic glutamate receptor responses

  T Tabata; A Aiba; M Kano

  MOLECULAR AND CELLULAR NEUROSCIENCE ACADEMIC PRESS INC ELSEVIER SCIENCE 20 (1) 56 - 68 1044-7431 2002/05 [Refereed]
  
• The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells

  T Yoshida; K Hashimoto; A Zimmer; T Maejima; K Araishi; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 22 (5) 1690 - 1697 0270-6474 2002/03 [Refereed]
  
• Motor discoordination in mutant mice lacking junctophilin type 3

  M Nishi; K Hashimoto; K Kuriyama; S Komazaki; M Kano; S Shibata; H Takeshima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 292 (2) 318 - 324 0006-291X 2002/03 [Refereed]
  
• Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation

  T Ohno-Shosaku; J Shosaku; H Tsubokawa; M Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL PUBLISHING LTD 15 (6) 953 - 961 0953-816X 2002/03 [Refereed]
  
• Heterogeneous intrinsic firing properties of vertebrate retinal ganglion cells

  T Tabata; M Kano

  JOURNAL OF NEUROPHYSIOLOGY AMER PHYSIOLOGICAL SOC 87 (1) 30 - 41 0022-3077 2002/01 [Refereed]
  
• Retrograde signaling at central synapses via endogenous cannabinoids

  M Kano; T Ohno-Shosaku; T Maejima

  MOLECULAR PSYCHIATRY NATURE PUBLISHING GROUP 7 (3) 234 - 235 1359-4184 2002 [Refereed]
  
• Roles of glutamate receptor delta 2 subunit (GluR delta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development

  K Hashimoto; R Ichikawa; H Takechi; Y Inoue; A Aiba; K Sakimura; M Mishina; T Hashikawa; A Konnerth; M Watanabe; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 21 (24) 9701 - 9712 0270-6474 2001/12 [Refereed]
  
• Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors

  T Maejima; K Hashimoto; T Yoshida; A Aiba; M Kano

  NEURON CELL PRESS 31 (3) 463 - 475 0896-6273 2001/08 [Refereed]
  
• Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals

  T Maejima; T Ohno-Shosaku; M Kano

  NEUROSCIENCE RESEARCH ELSEVIER SCI IRELAND LTD 40 (3) 205 - 210 0168-0102 2001/07 [Refereed]
  
• PSD-93 Knock-Out Mice Reveal That Neuronal MAGUKs Are Not Required for Development or Function of Parallel Fiber Synapses in Cerebellum

  Aaron W. McGee; J. Rick Topinka; Kouichi Hashimoto; Ronald S. Petralia; Sho Kakizawa; Frederick Kauer; Andrea Aguilera-Moreno; Robert J. Wenthold; Masanobu Kano; David S. Bredt

  The Journal of Neuroscience Society for Neuroscience 21 (9) 3085 - 3091 0270-6474 2001/05 [Refereed]
  
• Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta 4 mutant mice

  M Miyata; HT Kim; K Hashimoto; TK Lee; SY Cho; HP Jiang; YP Wu; KS Jun; DQ Wu; M Kano; HS Shin

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL SCIENCE LTD 13 (10) 1945 - 1954 0953-816X 2001/05 [Refereed]
  
• PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum

  AW McGee; Topinka, JR; K Hashimoto; RS Petralia; S Kakizawa; F Kauer; A Aguilera-Moreno; RJ Wenthold; M Kano; DS Bredt

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 21 (9) 3085 - 3091 0270-6474 2001/05 [Refereed]
  
• Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals

  T Ohno-Shosaku; T Maejima; M Kano

  NEURON CELL PRESS 29 (3) 729 - 738 0896-6273 2001/03 [Refereed]
  
• Roles of phospholipase C beta 4 in synapse elimination and plasticity in developing and mature cerebellum

  K Hashimoto; M Miyata; M Watanabe; M Kano

  MOLECULAR NEUROBIOLOGY HUMANA PRESS INC 23 (1) 69 - 82 0893-7648 2001/02 [Refereed]
  
• A reliable method for culture of dissociated mouse cerebellar cells enriched for Purkinje neurons

  Toshihide Tabata; Satsuki Sawada; Keiko Araki; Yukiko Bono; Shigeki Furuya; Masanobu Kano

  Journal of Neuroscience Methods 104 (1) 45 - 53 0165-0270 2000/12 [Refereed]
  
• L-Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons

  Shigeki Furuya; Toshihide Tabata; Junya Mitoma; Keiko Yamada; Miwako Yamasaki; Asami Makino; Toshifumi Yamamoto; Masahiko Watanabe; Masanobu Kano; Yoshio Hirabayashi

  Proceedings of the National Academy of Sciences of the United States of America 97 (21) 11528 - 11533 0027-8424 2000/10 [Refereed]
  
• Local calcium release in dendritic spines required for long-term synaptic depression

  M Miyata; EA Finch; L Khiroug; K Hashimoto; S Hayasaka; SI Oda; M Inouye; Y Takagishi; GJ Augustine; M Kano

  NEURON CELL PRESS 28 (1) 233 - 244 0896-6273 2000/10 [Refereed]
  
• Critical period for activity-dependent synapse elimination in developing cerebellum

  S Kakizawa; M Yamasaki; M Watanabe; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 20 (13) 4954 - 4961 0270-6474 2000/07 [Refereed]
  
• Calcium-dependent persistent facilitation of spike backpropagation in the CA1 pyramidal neurons

  H Tsubokawa; S Offermanns; M Simon; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 20 (13) 4878 - 4884 0270-6474 2000/07 [Refereed]
  
• mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination

  T Ichise; M Kano; K Hashimoto; D Yanagihara; K Nakao; R Shigemoto; M Katsuki; A Aiba

  SCIENCE AMER ASSOC ADVANCEMENT SCIENCE 288 (5472) 1832 - 1835 0036-8075 2000/06 [Refereed]
  
• Formation of hippocampal synapses on patterned substrates of a laminin-derived synthetic peptide

  M Matsuzawa; T Tabata; W Knoll; M Kano

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL SCIENCE LTD 12 (3) 903 - 910 0953-816X 2000/03 [Refereed]
  
• Gq protein alpha subunits G alpha q and G alpha 11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells

  J Tanaka; S Nakagawa; E Kushiya; M Yamasaki; M Fukaya; T Iwanaga; MI Simon; K Sakimura; M Kano; M Watanabe

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL SCIENCE LTD 12 (3) 781 - 792 0953-816X 2000/03 [Refereed]
  
• Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene

  K Kobayashi; Y Noda; N Matsushita; K Nishii; H Sawada; T Nagatsu; D Nakahara; R Fukabori; Y Yasoshima; T Yamamoto; M Miura; M Kano; T Mamiya; Y Miyamoto; T Nabeshima

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 20 (6) 2418 - 2426 0270-6474 2000/03 [Refereed]
  
• Corticotropin-releasing factor induces long-lasting depression of parallel fiber to Purkinje cell synaptic transmission in rat cerebellum.

  Miyata M (CA; Hashimoto.K; Kano M; Ito M

  J. Physiol (Paris) 90 419 - 421 2000 [Refereed]
  
• Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving G alpha q and phospholipase C beta 4

  K Hashimoto; M Watanabe; H Kurihara; S Offermanns; H Jiang; Y Wu; K Jun; HS Shin; Y Inoue; D Wu; MI Simon; M Kano

  CEREBELLAR MODULES: MOLECULES, MORPHOLOGY, AND FUNCTION ELSEVIER SCIENCE BV 124 31 - 48 0079-6123 2000 [Refereed]
  
• Heterosynaptic expression of depolarization-induced suppression of inhibition (DSI) in rat hippocampal cultures

  T Ohno-Shosaku; S Sawada; M Kano

  NEUROSCIENCE RESEARCH ELSEVIER SCI IRELAND LTD 36 (1) 67 - 71 0168-0102 2000/01 [Refereed]
  
• Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer

  K Hashimoto; M Fukaya; XX Qiao; K Sakimura; M Watanabe; M Kano

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 19 (14) 6027 - 6036 0270-6474 1999/07 [Refereed]
  
• Elevation of intracellular Na+ induced by hyperpolarization at the dendrites of pyramidal neurones of mouse hippocampus

  H Tsubokawa; M Miura; M Kano

  JOURNAL OF PHYSIOLOGY-LONDON WILEY 517 (1) 135 - 142 0022-3751 1999/05 [Refereed]
  
• Corticotropin-releasing factor plays a permissive role in cerebellar long-term depression

  M Miyata; D Okada; K Hashimoto; M Kano; M Ito

  NEURON CELL PRESS 22 (4) 763 - 775 0896-6273 1999/04 [Refereed]
  
• Phospholipase C beta 4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum

  M Kano; K Hashimoto; M Watanabe; H Kurihara; S Offermanns; HP Jiang; YP Wu; K Jun; HS Shin; Y Inoue; MI Simon; DQ Wu

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 95 (26) 15724 - 15729 0027-8424 1998/12 [Refereed]
  
• Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination

  D Watanabe; H Inokawa; K Hashimoto; N Suzuki; M Kano; R Shigemoto; T Hirano; K Toyama; S Kaneko; M Yokoi; K Moriyoshi; M Suzuki; K Kobayashi; T Nagatsu; RJ Kreitman; Pastan, I; S Nakanishi

  CELL CELL PRESS 95 (1) 17 - 27 0092-8674 1998/10 [Refereed]
  
• Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase C beta in mouse brain

  M Watanabe; M Nakamura; K Sato; M Kano; MI Simon; Y Inoue

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL SCIENCE LTD 10 (6) 2016 - 2025 0953-816X 1998/06 [Refereed]
  
• Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice

  K Watase; K Hashimoto; M Kano; K Yamada; M Watanabe; Y Inoue; S Okuyama; T Sakagawa; S Ogawa; N Kawashima; S Hori; M Takimoto; K Wada; K Tanaka

  EUROPEAN JOURNAL OF NEUROSCIENCE BLACKWELL SCIENCE LTD 10 (3) 976 - 988 0953-816X 1998/03 [Refereed]
  
• Presynaptic origin of paired-pulse depression at climbing fibre Purkinje cell synapses in the rat cerebellum

  K Hashimoto; M Kano

  JOURNAL OF PHYSIOLOGY-LONDON CAMBRIDGE UNIV PRESS 506 (2) 391 - 405 0022-3751 1998/01 [Refereed]
  
• Cerebellar motor learning and synaptic plasticity

  M Kano; K Hashimoto

  JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY JAPANESE SOC NEUROPSYCHOPHARMACOLOGY-JSNP 19 (12) 1137 - 1143 1340-2544 1997/12 [Refereed]
  
• Impaired parallel fiber->Purkinje cell synapse stabilization during cerebellar development of mutant mice lacking the glutamate receptor delta 2 subunit

  H Kurihara; K Hashimoto; M Kano; C Takayama; K Sakimura; M Mishina; Y Inoue; M Watanabe

  JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 17 (24) 9613 - 9623 0270-6474 1997/12 [Refereed]
  
• Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking G alpha q

  S Offermanns; K Hashimoto; M Watanabe; W Sun; H Kurihara; RF Thompson; Y Inoue; M Kano; MI Simon

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 94 (25) 14089 - 14094 0027-8424 1997/12 [Refereed]
  
• Cerebellar motor learning and synaptic plasticity

  M. Kano; K. Hashimoto

  Japanese Journal of Neuropsychopharmacology 19 (12) 1137 - 1143 0388-7588 1997
• The Gαq isoform of heterotrimeric G protein and the phospholipase C β4 are required for climbing fiber synapse elimination during postnatal cerebellar development

  Masanobu Kano; Kouichi Hashimoto; Stefan Offermanns; Melvin I. Simon; Masahiko Watanabe; Hideo Kurihara; Yoshiro Inoue; Huiping Jiang; Yanping Wu; Ki-Su Jun; Dianqing Wu; Hee-SUP Shin

  Keio Journal of Medicine 46 A108 - A119 1880-1293 1997 [Refereed]
  
• Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1

  M Kano; K Hashimoto; H Kurihara; M Watanabe; Y Inoue; A Aiba; S Tonegawa

  NEURON CELL PRESS 18 (1) 71 - 79 0896-6273 1997/01 [Refereed]
  
• Ca2+-induced rebound potentiation of gamma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II

  M Kano; M Kano; K Fukunaga; A Konnerth

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA NATL ACAD SCIENCES 93 (23) 13351 - 13356 0027-8424 1996/11 [Refereed]
  
• Long-lasting potentiation of GABAergic inhibitory synaptic transmission in cerebellar Purkinje cells: Its properties and possible mechanisms

  M Kano

  BEHAVIORAL AND BRAIN SCIENCES CAMBRIDGE UNIV PRESS 19 (3) 354 - & 0140-525X 1996/09 [Refereed]
  
• New players for cerebellar long-term depression

  M Kano

  BEHAVIORAL AND BRAIN SCIENCES CAMBRIDGE UNIV PRESS 19 (3) 462 - & 0140-525X 1996/09 [Refereed]
  
• A bridge between cerebellar long-term depression and discrete motor learning: Studies on gene knockout mice - Response

  M Kano

  BEHAVIORAL AND BRAIN SCIENCES CAMBRIDGE UNIV PRESS 19 (3) 488 - & 0140-525X 1996/09 [Refereed]
  
• Corticotropin releasing factor (CRF) induces longlasting depression of parallel fiber to Purkinje cell synaptic transmission in rat cerebellum

  M. Miyata; K. Hashimoto; M. Kano; M. Ito

  Journal of Physiology Paris Elsevier Masson SAS 90 (5-6) 419 - 420 0928-4257 1996 [Refereed]
  
• Fractional calcium current through neuronal AMPA-receptor channels with a low calcium permeability

  F Tempia; M Kano; R Schneggenburger; C Schirra; O Garaschuk; T Plant; A Konnerth

  JOURNAL OF NEUROSCIENCE OXFORD UNIV PRESS INC 16 (2) 456 - 466 0270-6474 1996/01 [Refereed]
  
• Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice

  C Chen; M Kano; A Abeliovich; L Chen; SW Bao; JJ Kim; K Hashimoto; RF Thompson; S Tonegawa

  CELL CELL PRESS 83 (7) 1233 - 1242 0092-8674 1995/12 [Refereed]
  
• Impaired synapse elimination during cerebellar development in PKC gamma mutant mice

  M Kano; K Hashimoto; C Chen; A Abeliovich; A Aiba; H Kurihara; M Watanabe; Y Inoue; S Tonegawa

  CELL CELL PRESS 83 (7) 1223 - 1231 0092-8674 1995/12 [Refereed]
  
• Depolarization-induced calcium signals in the somata of cerebellar Purkinje neurons

  M Kano; R Schneggenburger; A Verkhratsky; A Konnerth

  NEUROSCIENCE RESEARCH ELSEVIER SCI IRELAND LTD 24 (1) 87 - 95 0168-0102 1995/12 [Refereed]
  
• RYANODINE RECEPTOR-MEDIATED INTRACELLULAR CALCIUM-RELEASE IN RAT CEREBELLAR PURKINJE NEURONS

  M KANO; O GARASCHUK; A VERKHRATSKY; A KONNERTH

  JOURNAL OF PHYSIOLOGY-LONDON CAMBRIDGE UNIV PRESS 487 (1) 1 - 16 0022-3751 1995/08 [Refereed]
  
• PLASTICITY OF INHIBITORY SYNAPSES IN THE BRAIN - A POSSIBLE MEMORY MECHANISM THAT HAS BEEN OVERLOOKED

  M KANO

  NEUROSCIENCE RESEARCH ELSEVIER SCI PUBL IRELAND LTD 21 (3) 177 - 182 0168-0102 1995/01 [Refereed]
  
• DEFICIENT CEREBELLAR LONG-TERM DEPRESSION AND IMPAIRED MOTOR LEARNING IN MGLUR1 MUTANT MICE

  A AIBA; M KANO; C CHEN; ME STANTON; GD FOX; K HERRUP; TA ZWINGMAN; S TONEGAWA

  CELL CELL PRESS 79 (2) 377 - 388 0092-8674 1994/10 [Refereed]
  
• LONG-LASTING REBOUND POTENTIATION OF GABA-MEDIATED INHIBITORY SYNAPTIC CURRENTS IN CEREBELLAR PURKINJE-CELLS

  M KANO

  BIOMEDICAL RESEARCH-TOKYO BIOMED RES FOUND 15 69 - 72 0388-6107 1994 [Refereed]
  
• CALCIUM-INDUCED LONG-LASTING POTENTIATION OF GABAERGIC CURRENTS IN CEREBELLAR PURKINJE-CELLS

  M KANO

  JAPANESE JOURNAL OF PHYSIOLOGY CENTER ACAD PUBL JAPAN 44 S131 - S136 0021-521X 1994 [Refereed]
  
• POTENTIATION OF GABA-MEDIATED CURRENTS BY CAMP-DEPENDENT PROTEIN-KINASE

  M KANO; A KONNERTH

  NEUROREPORT RAPID SCIENCE PUBLISHERS 3 (7) 563 - 566 0959-4965 1992/07 [Refereed]
  
• SYNAPTIC EXCITATION PRODUCES A LONG-LASTING REBOUND POTENTIATION OF INHIBITORY SYNAPTIC SIGNALS IN CEREBELLAR PURKINJE-CELLS

  M KANO; U REXHAUSEN; J DREESSEN; A KONNERTH

  NATURE MACMILLAN MAGAZINES LTD 356 (6370) 601 - 604 0028-0836 1992/04 [Refereed]
  
• INTRADENDRITIC RELEASE OF CALCIUM INDUCED BY GLUTAMATE IN CEREBELLAR PURKINJE-CELLS

  LLANO, I; J DREESSEN; M KANO; A KONNERTH

  NEURON CELL PRESS 7 (4) 577 - 583 0896-6273 1991/10 [Refereed]
  
• BINOCULAR INTERACTION AND SIGNAL COMPONENTS OF OPTOKINETIC RESPONSES OF CLIMBING FIBER AFFERENTS IN THE CEREBELLAR FLOCCULUS AND NODULUS OF THE PIGMENTED RABBIT

  M KANO; M KANO; K MAEKAWA

  NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 12 (1) 151 - 159 0168-0102 1991/10 [Refereed]
  
• SIMPLE SPIKE MODULATION OF PURKINJE-CELLS IN THE CEREBELLAR NODULUS OF THE PIGMENTED RABBIT TO OPTOKINETIC STIMULATION

  M KANO; MS KANO; K MAEKAWA

  NEUROSCIENCE LETTERS ELSEVIER SCI IRELAND LTD 128 (1) 101 - 104 0304-3940 1991/07 [Refereed]
  
• FUNCTIONAL REORGANIZATION OF ADULT CAT SOMATOSENSORY CORTEX IS DEPENDENT ON NMDA RECEPTORS

  M KANO; K IINO; M KANO

  NEUROREPORT RAPID SCIENCE PUBLISHERS 2 (2) 77 - 80 0959-4965 1991/02 [Refereed]
  
• OPTOKINETIC RESPONSE OF CELLS IN THE NUCLEUS-RETICULARIS TEGMENTI PONTIS OF THE PIGMENTED RABBIT

  M KANO; K IINO; K MAEKAWA; MS KANO

  EXPERIMENTAL BRAIN RESEARCH SPRINGER VERLAG 87 (2) 239 - 244 0014-4819 1991 [Refereed]
  
• OPTOKINETIC RESPONSE OF SIMPLE SPIKES OF PURKINJE-CELLS IN THE CEREBELLAR FLOCCULUS AND NODULUS OF THE PIGMENTED RABBIT

  M KANO; MS KANO; K MAEKAWA

  EXPERIMENTAL BRAIN RESEARCH SPRINGER VERLAG 87 (3) 484 - 496 0014-4819 1991 [Refereed]
  
• RECEPTIVE-FIELD ORGANIZATION OF CLIMBING FIBER AFFERENTS RESPONDING TO OPTOKINETIC STIMULATION IN THE CEREBELLAR-NODULUS AND FLOCCULUS OF THE PIGMENTED RABBIT

  MS KANO; M KANO; K MAEKAWA

  EXPERIMENTAL BRAIN RESEARCH SPRINGER VERLAG 82 (3) 499 - 512 0014-4819 1990 [Refereed]
  
• NATURE OF OPTOKINETIC RESPONSE AND ZONAL ORGANIZATION OF CLIMBING FIBER AFFERENTS IN THE VESTIBULOCEREBELLUM OF THE PIGMENTED RABBIT .1. THE FLOCCULUS

  M KUSUNOKI; M KANO; MS KANO; K MAEKAWA

  EXPERIMENTAL BRAIN RESEARCH SPRINGER VERLAG 80 (2) 225 - 237 0014-4819 1990 [Refereed]
  
• NATURE OF OPTOKINETIC RESPONSE AND ZONAL ORGANIZATION OF CLIMBING FIBER AFFERENTS IN THE VESTIBULOCEREBELLUM OF THE PIGMENTED RABBIT .2. THE NODULUS

  M KANO; MS KANO; M KUSUNOKI; K MAEKAWA

  EXPERIMENTAL BRAIN RESEARCH SPRINGER VERLAG 80 (2) 238 - 251 0014-4819 1990 [Refereed]
  
• STIMULATION PARAMETERS INFLUENCING CLIMBING FIBER INDUCED LONG-TERM DEPRESSION OF PARALLEL FIBER SYNAPSES

  CF EKEROT; M KANO

  NEUROSCIENCE RESEARCH ELSEVIER SCI IRELAND LTD 6 (3) 264 - 268 0168-0102 1989/02 [Refereed]
  
• MODE OF INDUCTION OF LONG-TERM DEPRESSION AT PARALLEL FIBER PURKINJE-CELL SYNAPSES IN RABBIT CEREBELLAR CORTEX

  M KANO; M KATO

  NEUROSCIENCE RESEARCH ELSEVIER SCI IRELAND LTD 5 (6) 544 - 556 0168-0102 1988/08 [Refereed]
  
• THE GLUTAMATE RECEPTOR SUBTYPE MEDIATING PARALLEL FIBER PURKINJE-CELL TRANSMISSION IN RABBIT CEREBELLAR CORTEX

  M KANO; M KATO; HS CHANG

  NEUROSCIENCE RESEARCH ELSEVIER SCI IRELAND LTD 5 (4) 325 - 337 0168-0102 1988/04 [Refereed]
  
• QUISQUALATE RECEPTORS ARE SPECIFICALLY INVOLVED IN CEREBELLAR SYNAPTIC PLASTICITY

  M KANO; M KATO

  NATURE MACMILLAN MAGAZINES LTD 325 (6101) 276 - 279 0028-0836 1987/01 [Refereed]
  
• Synaptic organization of the cerebello-thalamo-cerebral pathway in the cat. III. Cerebellar input to corticofugal neurons destined for different subcortical nuclei in areas 4 and 6

  Takahiro Futami; Masanobu Kano; Seishiro Sento; Yoshikazu Shinoda

  Neuroscience Research 3 (4) 321 - 344 0168-0102 1986 [Refereed]
  
• LONG-TERM DEPRESSION OF PARALLEL FIBER SYNAPSES FOLLOWING STIMULATION OF CLIMBING FIBERS

  CF EKEROT; M KANO

  BRAIN RESEARCH ELSEVIER SCIENCE BV 342 (2) 357 - 360 0006-8993 1985 [Refereed]
  
• LONG-LASTING DEPRESSION OF PARALLEL FIBER PURKINJE-CELL TRANSMISSION INDUCED BY CONJUNCTIVE STIMULATION OF PARALLEL FIBERS AND CLIMBING FIBERS IN THE CEREBELLAR CORTEX

  M ITO; M KANO

  NEUROSCIENCE LETTERS ELSEVIER SCI IRELAND LTD 33 (3) 253 - 258 0304-3940 1982 [Refereed]
  

MISC

• NMDA receptor-dependent molecular plasticity in dendritic spines of the cerebral cortex after somatosensory stimulation

  KUBOYAMA Kazuya; INOUE Takafumi; HASHIMOTODANI Yuki; ITOH Takuya; SUZUKI Tohsuke; TETSUZAWA Aya; KINOSHITA Ryo; OHTSUKA Yosuke; TAKARA Ren; MIYAZAWA Tohru; GUSAIN Pooja; TAWATA Masakiyo; KANO Masanobu; YAMADA Maki  日本薬理学会年会要旨集(Web)  93rd-  2020
• AiCEマウスを用いた片側感覚刺激後における左右半球比較による樹状突起スパインの可塑的変化の観察

  宮澤徹; 久保山和哉; 井上貴文; 橋本谷祐輝; 伊藤拓矢; 鈴木東介; 鉄澤愛彩; 木下諒; 大塚庸介; 高良廉; POOJA Gusain; 多和田真聖; 狩野方伸; 山田麻紀  日本薬理学雑誌  155-  (Supplement)  2020
• 小脳神経回路の生後発達

  渡邉貴樹; 鈴木穂香; 狩野方伸  Brain and Nerve  71-  1373  -1383  2019
• 脳機能を支えるシナプスの機能発達、可塑性および伝達修飾の研究

  狩野 方伸  日本医師会雑誌  147-  (9)  1844  -1847  2018  [Refereed][Invited]
  
• 発達期シナプス刈り込みの細胞・分子機構

  狩野 方伸  細胞  50 (14)-  13(727)  -16(730)  2018  [Refereed][Invited]
  
• マリファナ類似伝達物質 内因性カンナビノイドの役割と意義．DOJIN BIOSCIENCE SERIES 28 脳神経科学－脳はいま化学の言葉でどこまで語れるか．森 泰生、尾藤晴彦／編

  橋本谷祐輝; 菅谷佑樹; 狩野方伸  化学同人  104  -112  2018  [Refereed][Invited]
  
• GLUD1 deficient mouse as a model animal of depressionlike behavior

  K. Sakimura; C. Nakamoto; M. Abe; M. Kawamura; H. Uchida; M. Watanabe; M. Kano  JOURNAL OF NEUROCHEMISTRY  142-  203  -203  2017/08
• 小脳登上線維-プルキンエ細胞間シナプスの精緻化へのグリア細胞の関与

  菊地原 沙織; 杉尾 翔太; 稲村 直子; 渡辺 雅彦; 田中 謙二; 渡邉 貴樹; 狩野 方伸; 山崎 良彦; 池中 一裕  日本生理学雑誌  79-  (1)  23  -23  2017/02
• Synaptogenesis and synapse elimination in developing cerebellum

  Kouichi Hashimoto; Masahiko Watanabe; Masanobu Kano  Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students  18-  161  -165  2016/01  [Refereed][Invited]
  
• Mechanisms of synapse pruning in the developing cerebellum

  Watanabe T; Uesaka N; Kano M  Seikagaku. The Journal of Japanese Biochemical Society  88-  (5)  621  -629  2016  [Refereed][Invited]
  
• Rational design of a high-affinity, fast, red calcium indicator R-CaMP2 (vol 12, pg 64, 2015)

  Masatoshi Inoue; Atsuya Takeuchi; Shin-ichiro Horigane; Masamichi Ohkura; Keiko Gengyo-Ando; Hajime Fujii; Satoshi Kamijo; Sayaka Takemoto-Kimura; Masanobu Kano; Junichi Nakai; Kazuo Kitamura; Haruhiko Bito  NATURE METHODS  12-  (9)  893  -893  2015/09
• A unique western blot method to measure the number of glutamate receptor subunits

  K. Sakimura; C. Nishikawa; I. Watanabe; C. Nakamoto; Y. Suzuki; H. Azechi; R. Natsume; M. Abe; M. Watanabe; M. Kano  JOURNAL OF NEUROCHEMISTRY  134-  163  -163  2015/08
• Rational design of a high-affinity, fast, red calcium indicator R-CaMP2

  Masatoshi Inoue; Atsuya Takeuchi; Shin-ichiro Horigane; Masamichi Ohkura; Keiko Gengyo-Ando; Hajime Fujii; Satoshi Kamijo; Sayaka Takemoto-Kimura; Masanobu Kano; Junichi Nakai; Kazuo Kitamura; Haruhiko Bito  JOURNAL OF PHARMACOLOGICAL SCIENCES  128-  (3)  S92  -S92  2015/07
• 脳神経回路リモデリング 発達期におけるシナプス刈り込みと逆行性シグナル

  上阪直史; 狩野方伸  実験医学  33-  (9)  1364  -1370  2015/06
• Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy

  Ivan Soltesz; Bradley E. Alger; Masanobu Kano; Sang-Hun Lee; David M. Lovinger; Takako Ohno-Shosaku; Masahiko Watanabe  NATURE REVIEWS NEUROSCIENCE  16-  (5)  264  -277  2015/05
• 発達期におけるシナプス刈り込みと逆行性シグナル

  上阪直史; 狩野方伸  実験医学  33-  1386  -1390  2015  [Refereed][Invited]
  
• 内因性カンナビノイドによるシナプス伝達調節

  狩野 方伸  お茶の水醫學雑誌  63-  53  -65  2015  [Refereed][Invited]
  
• Brain-enriched Sorting Nexin Family Proteins Regulate Spine Morphogenesis and Are Associated with Risk for Schizophrenia

  Takanobu Nakazawa; Ryota Hashimoto; Asami Tanimura; Kazutaka Ohi; Hidenaga Yamamori; Yuka Yasuda; Satomi Umeda-Yano; Yuji Kiyama; Kohtarou Konno; Takafumi Inoue; Shusuke Numata; Tohru Ohnuma; Nakao Iwata; Norio Ozaki; Hitoshi Hashimoto; Masahiko Watanabe; Toshiya Manabe; Tadashi Yamamoto; Masatoshi Takeda; Masanobu Kano  NEUROPSYCHOPHARMACOLOGY  39-  S306  -S307  2014/12
• Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE (vol 10, pg 889, 2013)

  Takashi Kawashima; Kazuo Kitamura; Kanzo Suzuki; Mio Nonaka; Satoshi Kamijo; Sayaka Takemoto-Kimura; Masanobu Kano; Hiroyuki Okuno; Kenichi Ohki; Haruhiko Bito  NATURE METHODS  11-  (2)  210  -210  2014/02
• Requirement of mGluR1 for Experience-Dependent Remodeling of Mouse Retinogeniculate Synapses

  M. Kano; M. Narushima; M. Uchigashima; M. Watanabe; A. Aiba; M. Miyata  CURRENT NEUROPHARMACOLOGY  12-  30  -31  2014
• 脳の機能発達を担うシナプス刈り込みの機構

  上阪直史; 川田慎也; 狩野方伸  Brain and Nerve  9-  1069  -1077  2014  [Refereed][Invited]
  
• Cav2.1カルボキシル末端細胞質内ドメインの病態生理学的意義の検討

  相川 知徳; 宮崎 太輔; 三國 貴康; 重本 隆一; 若森 実; 狩野 方伸; 渡邊 雅彦; 水澤 英洋; 渡瀬 啓  臨床神経学  53-  (12)  1495  -1495  2013/12
• Relationship between the synchrony of climbing fiber activities and the aldolase C compartments in mouse cerebellar cortex

  Shinichiro Tsutsumi; Mayumi Tada; Kenji Sakimura; Kazuo Kitamura; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  63-  S128  -S128  2013
• The endocannabinoid 2-arachidonoylglycerol suppresses excitatory synaptic input to the dentate gyrus and ameliorates seizures

  Yuki Sugaya; Maya Yamazaki; Kenji Sakimura; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  63-  S149  -S149  2013
• Climbing fiber network refinement and desynchronization of Purkinje cell population activity during postnatal cerebellar development

  Jean-Marc Good; Kazuo Kitamura; Kenji Sakimura; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  63-  S242  -S242  2013
• Cerebellar Circuits

  M. Kano; M. Watanabe  Neural Circuit Development and Function in the Heathy and Diseased Brain  3-  75  -93  2013  [Refereed][Invited]
  
• 小脳におけるシナプス刈り込みと神経回路発達

  狩野 方伸  日本神経精神薬理学雑誌  33-  137  -140  2013  [Refereed][Invited]
  
• The interaction between serotonergic and cannabinoidergic modulations involved in the fear extinction.

  吉田隆行; 狩野方伸; 渡辺雅彦; 吉岡充弘  日本神経精神薬理学雑誌  33-  (3)  95  -99  2013  [Refereed][Invited]
  
• Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus

  吉田 隆行; 内ヶ島 基政; 山崎 美和子; イストバンカトナ; 山崎 真弥; 崎村 建司; 狩野 方伸; 吉岡 充弘; 渡辺 雅彦  北海道醫學雜誌 = Acta medica Hokkaidonensia  87-  (2)  72  -72  2012/04
• in vivo two-photon imaging of dendritic activity of cerebellar Purkinje cell

  Kazuo Kitamura; Kouichi Hashimoto; Masanobu Kano  Seitai no Kagaku  63-  (1)  26  -33  2012/02  [Invited]
  
• Synaptogenesis and Synaptic Elimination

  Kano M; Watanabe M  Handbook of Cerebellum and Cerebellar Disorders  281  -299  2012  [Refereed][Invited]
  
• Unique inhibitory Synapse with Particularly Rich Endocannabinoid Signaling Machinery on Pyramidal Neurons in Basal Amygdaloid Nucleus

  T. Yoshida; M. Uchigashima; M. Yamasaki; I. Katona; M. Yamazaki; K. Sakimura; M. Kano; M. Yoshioka; M. Watanabe  CURRENT NEUROPHARMACOLOGY  9-  68  -68  2011/09
• アンジオテンシンII受容体拮抗薬はアルツハイマー病モデルマウスにおけるNeurovascularcouplingを回復し認知機能障害を改善する

  武田朱公; 里直行; 新里和恵; 篠原充; 狩野方伸; 荻原俊男; 樂木宏実; 森下竜一  日本老年医学会雑誌  48-  (4)  414  2011/07
• COMPLEMENTARY SYNAPTIC DISTRIBUTION OF ENZYMES RESPONSIBLE FOR SYNTHESIS AND INACTIVATION OF THE ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL IN THE HUMAN HIPPOCAMPUS (vol 174, pg 50, 2011)

  A. Ludanyi; S. S. -J. Hu; M. Yamazaki; A. Tanimura; D. Piomelli; M. Watanabe; M. Kano; K. Sakimura; Z. Magloczky; K. Mackie; T. F. Freund; I. Katona  NEUROSCIENCE  186-  220  -220  2011/06
• Roles of Purkinje cell activity in climbing fiber synapse elimination in an organotypic coculture preparation of the cerebellum and medulla oblongata

  Takayasu Mikuni; Naofumi Uesaka; Masanobu Kano  NEUROSCIENCE RESEARCH  71-  E93  -E93  2011
• Enhanced synchrony of climbing fiber-induced Ca2+ signaling in cerebellar Purkinje cells in GluD2 (GluR delta 2) knockout mouse

  Miki Hashizume; Kazuo Kitamura; Kenji Sakimura; Masanobu Kano  NEUROSCIENCE RESEARCH  71-  E247  -E247  2011
• The endocannabinoid, 2-arachidonoylglycerol, has different effects on long-term potentiation in vivo between the dentate gyrus and the hippocampal CA1

  Yuki Sugaya; Asami Tanimura; Maya Yamazaki; Kenji Sakimura; Masanobu Kano  NEUROSCIENCE RESEARCH  71-  E87  -E87  2011
• Postsynaptic P/Q type voltage-dependent Ca2+ channel is involved in refinement of cerebellar climbing fiber to Purkinje cell synapses in early postnatal development

  Kouichi Hashimoto; Mika Tsujita; Taisuke Miyazaki; Kazuo Kitamura; Maya Yamazaki; Shin Hee-sup; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano  NEUROSCIENCE RESEARCH  71-  E322  -E322  2011
• Adenosine A1 receptor interacts with mGluR1 and regulates cerebellar LTD

  Yuji Kamikubo; Yosuke Fujita; Takeshi Shimomura; Takaaki Miyajima; Masahiro Fujino; Toshihide Tabata; Kenkichi Fukurotani; Masanobu Kano; Takashi Sakurai  NEUROSCIENCE RESEARCH  71-  E111  -E111  2011
• Synapse "non-specific" degradation of the endocannabinoid 2-arachidonoylglycerol mediating depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells

  Asami Tanimura; Maya Yamazaki; Motokazu Uchigashima; Naofumi Uesaka; Takayasu Mikuni; Kouichi Hashimoto; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano  NEUROSCIENCE RESEARCH  71-  E56  -E56  2011
• P2-u14 In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice

  Jun Noguchi; Akira Nagaoka; Satoshi Watanabe; Graham C. R. Ellis-Davies; Kazuo Kitamura; Masanobu Kano; Masanori Matsuzaki; Haruo Kasai  NEUROSCIENCE RESEARCH  71-  E206  -E206  2011
• Endocannabinoid-mediated modulation of synaptic transmission and its impact on integrative brain functions

  Masanobu Kano  NEUROSCIENCE RESEARCH  71-  E5  -E5  2011
• Impaired reward-related behaviors in mice lacking the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha

  Barbara Cagniard; Asami Tanimura; Maya Yamazaki; Kenji Sakimura; Masanobu Kano  NEUROSCIENCE RESEARCH  71-  E73  -E73  2011
• Adenosine A(1) receptor regulates metabotropic glutamate receptor signaling and synaptic plasticity in central neurons

  Toshihide Tabata; Yuji Kamikubo; Yosuke Fujita; Takeshi Shimomura; Masahiro Fujino; Takaaki Miyajima; Takashi Sakurai; Kenkichi Fukurotani; Masanobu Kano  JOURNAL OF PHARMACOLOGICAL SCIENCES  115-  28P  -28P  2011
• Desynchronization of cerebellar Purkinje cell population activity during postnatal development

  Jean-Marc Good; Kazuo Kitamura; Masanobu Kano  NEUROSCIENCE RESEARCH  71-  E60  -E60  2011
• 内因性カンナビノイドによるシナプス伝達調節のメカニズム

  谷村あさみ; 橋本谷祐輝; 狩野方伸  生化学  83-  704  -714  2011  [Refereed][Invited]
  
• シナプス伝達を修飾する脂質メディエーター、内因性カンナビノイド

  橋本谷祐輝; 谷村あさみ; 狩野方伸  日本神経精神薬理学雑誌  31-  105  -109  2011  [Refereed][Invited]
  
• 小脳回路 発達と可塑性の最前線 登上線維の発達過程におけるP/Q型電位依存性カルシウムチャネルの役割(Cellebellar circuitry: Cutting-edge of development and plasticity P/Q type voltage dependent Ca2+ channel is crucial for early postnatal development of climbing fiber to Purkinje cell synapse)

  橋本 浩一; 辻田 実加; 喜多村 和郎; 宮崎 太輔; 山崎 真弥; Shin Hee-Sup; 渡辺 雅彦; 崎村 建司; 狩野 方伸  神経化学  49-  (2-3)  461  -461  2010/08
• 小脳と延髄との共培養標本を用いたシナプス発達のメカニズムを解明するためのアプローチ方法(An in vitro coculture preparation suitable for investigating the mechanisms of synapse development in rodent cerebellum)

  上阪 直史; 三國 貴康; 狩野 方伸  神経化学  49-  (2-3)  481  -481  2010/08
• 中枢神経系の組織培養細胞における効果的な神経活動の操作(Effective modification of neural activity in CNS organotypic cultures)

  三國 貴康; 上阪 直史; 狩野 方伸  神経化学  49-  (2-3)  539  -539  2010/08
• Cannabinoid receptor

  橋本谷 祐輝; 狩野 方伸  医学のあゆみ  233-  (9)  912  -917  2010/05
• 2-Arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission in the CNS

  Asami Tanimura; Maya Yamazaki; Yuki Hashimotodani; Motokazu Uchigashima; Shinya Kawata; Manabu Abe; Yoshihiro Kita; Kouichi Hashimoto; Takao Shimizu; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano  NEUROSCIENCE RESEARCH  68-  E88  -E88  2010
• Effective modification of neural activity in CNS organotypic cultures

  Takayasu Mikuni; Naofumi Uesaka; Masanobu Kano  NEUROSCIENCE RESEARCH  68-  E135  -E135  2010
• Two-photon imaging of population activity from cerebellar Purkinje cells in GluD2(GluR delta 2) knockout mouse

  Miki Hashizume; Kazuo Kitamura; Kenji Sakimura; Masanobu Kano  NEUROSCIENCE RESEARCH  68-  E64  -E64  2010
• Molecular mechanisms for the induction of retrograde endocannabinoid signaling

  Yuki Hashimotodani; Takako Ohno-Shosaku; Asami Tanimura; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  60-  S47  -S47  2010
• Applications of gene transfer techniques to CNS organotypic cultures

  Takayasu Mikuni; Naofumi Uesaka; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  60-  S135  -S135  2010
• Crosstalk between Adenosine A1 receptor and mGluR1 regulates LTD in cerebellar Purkinje cells

  Yuji Kamikubo; Takeshi Shimomura; Yosuke Fujita; Toshihide Tabata; Masanobu Kano; Takashi Sakurai  JOURNAL OF PHARMACOLOGICAL SCIENCES  112-  78P  -78P  2010
• Signal-crosstalk between mGluR1 and A1R regulates LTD in cerebellar Purkinje cells

  Yuji Kamikubo; Yosuke Fujita; Takeshi Shimomura; Toshihide Tabata; Kenkichi Fukurotani; Takashi Sakurai; Masanobu Kano  NEUROSCIENCE RESEARCH  68-  E339  -E339  2010
• Endocannabinoid and serotonin modulate GABAergic and glutamatergic transmission in the basolateral amygdala

  Takayuki Yoshida; Motokazu Uchigashima; Takeshi Izumi; Taku Yamaguchi; Masanobu Kano; Masahiko Watanabe; Mitsuhiro Yoshioka  NEUROSCIENCE RESEARCH  68-  E229  -E229  2010
• P/Q type voltage-dependent Ca2+ channel is required for refinement of climbing fiber to Purkinje cell synapse in early postnatal development

  Kouichi Hashimoto; Mika Tsujita; Taisuke Miyazaki; Maya Yamazaki; Kazuo Kitamura; Hee-sup Shin; Masahiko Watanabe; Kenji Sakimura; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  60-  S83  -S83  2010
• Analysis of physiological functions of cerebellar AMPA receptor subunits using a Purkinje cell-selective gene targeting system

  Manabu Abe; Kouichi Hashimoto; Taisuke Miyazaki; Hirotsugu Azechi; Rie Natsume; Masahiko Watanabe; Masanobu Kano; Kenji Sakimura  NEUROSCIENCE RESEARCH  68-  E231  -E231  2010
• An in vitro coculture preparation suitable for investigating the mechanisms of synapse development in rodent cerebellum

  Naofumi Uesaka; Takayasu Mikuni; Masanobu Kano  NEUROSCIENCE RESEARCH  68-  E61  -E61  2010
• 逆行性シナプス伝達における内因性カンナビノイドシグナリングの分子機構

  橋本谷祐輝; 狩野方伸  生体の科学  61-  (5)  384  -385  2010
• GABAB receptor-mediated modulation of metabotropic glutamate signaling and synaptic plasticity in central neurons

  Toshihide Tabata; Masanobu Kano  Advances in Pharmacology  58-  (C)  149  -173  2010  [Refereed]
  
• 内因性カンナビノイドによるシナプス伝達修飾

  橋本谷祐輝; 谷村あさみ; 狩野方伸  実験医学  28-  209  -214  2010  [Refereed][Invited]
  
• 長期抑圧（LTD）

  谷村あさみ; 橋本谷祐輝; 狩野方伸  Clinical Neuroscience  28-  873  -875  2010  [Refereed][Invited]
  
• カンナビノイド受容体 －逆行性シナプス伝達を担う分子－

  橋本谷祐輝; 狩野方伸  医学のあゆみ  233-  912  -917  2010  [Refereed][Invited]
  
• 新しい神経伝達物質 内因性カンナビノイド--逆行性シナプス伝達を担う分子 (特集 脳の分子論--化学的にどこまで迫れるか)

  谷村あさみ; 橋本谷祐輝; 狩野方伸  化学  64-  (12)  22  -26  2009/02  [Refereed][Invited]
  
• 2-arachidonoylglycerol mediates short-term retrograde suppression at cerebellar parallel fiber to Purukinje cell synapses in young adult mice

  Asami Tanimura; Shinya Kawata; Kouichi Hashimoto; Masanobu Kano  NEUROSCIENCE RESEARCH  65-  S52  -S52  2009
• TWO-PHOTON IMAGING OF POPULATION ACTIVITY IN CEREBELLAR PURKINJE CELLS IN GLUR delta 2 KNOCKOUT MOUSE

  Miki Hashizume; Kazuo Kitamura; Kenji Sakimura; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  429  -429  2009
• GABAergic inhibition onto Purkinje cell soma is crucial for climbing fiber synapse elimination in developing cerebellum

  Hisako Nakayama; Taisuke Miyazaki; Kouichi Hashimoto; Yuchio Yanagawa; Kunihiko Obata; Masahiko Watanabe; Masanobu Kano  NEUROSCIENCE RESEARCH  65-  S52  -S52  2009
• ANALYSIS OF CLIMBING FIBER INPUTS TO PURKINJE CELLS IN THE DEVELOPING RAT CEREBELLUM IN VIVO

  Yoshinobu Kawamura; Hisako Nakayama; Kazuo Kitamura; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  137  -137  2009
• MODULATION OF HIPPOCAMPAL INHIBITORY SYNAPTIC TRANSMISSION THROUGH PROTEASE-ACTIVATED RECEPTOR 1

  Yuki Hashimotodani; Takako Ohno-Shosaku; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  146  -146  2009
• GPCR signal crosstalk regulates mGluR1 signaling and LTD in cerebellar Purkinje cells

  Yuji Kamikubo; Toshihide Tabata; Yosuke Fujita; Takeshi Shimomura; Takashi Sakurai; Masanobu Kano  JOURNAL OF PHARMACOLOGICAL SCIENCES  109-  126P  -126P  2009
• mGluR1 is essential for acquisition but not for expression or retention in eyeblink conditioning

  Harumi Nakao; Yasushi Kishimoto; Kouichi Hashimoto; Kazuki Nakao; Masanobu Kano; Yutaka Kirino; Atsu Aiba  NEUROSCIENCE RESEARCH  65-  S188  -S188  2009
• Gene transfer techniques for CNS organotypic cultures

  Naofumi Uesaka; Takayasu Mikuni; Masanobu Kano  NEUROSCIENCE RESEARCH  65-  S132  -S133  2009
• A1 adenosine receptor as a regulator of the long-term depression of the glutamate-responsiveness of cerebellar Purkinje cells

  Yosuke Fujita; Takeshi Shimomura; Yuji Kamikubo; Toshihide Tabata; Kenkichi Fukurotani; Takashi Sakurai; Masanobu Kano  NEUROSCIENCE RESEARCH  65-  S42  -S42  2009
• TRANSLOCATION OF THE STRONGEST CLIMBING FIBER TO PURKINJE CELL DENDRITES AFTER SYNAPTIC COMPETITION ON THE SOMA IN DEVELOPING CREBELLUM

  Kouichi Hashimoto; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  138  -138  2009
• BI-DIRECTIONAL REGULATION OF CEREBELLAR SYNAPTIC PLASTICITY THROUGH INTER-GPCR INTERPLAY

  Yuji Kamikubo; Takeshi Shimomura; Yosuke Fujita; Toshihide Tabata; Takashi Sakurai; Kenkichi Fukurotani; Masanobu Kano  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  136  -136  2009
• 小脳プルキンエ細胞におけるERK経路の役割

  HARADA TAKESHI; HIRAI YOSHIE; YAMASAKI MIWAKO; HASHIMOTO KOICHI; KISHIMOTO YASUSHI; NAKAO HARUMI; TABATA TOSHIHIDE; NAKAO KAZUKI; KIRINO YUTAKA; WATANABE MASAHIKO; KANO MASANOBU; AIBA ATSUSHI  神経組織の成長・再生・移植研究会学術集会プログラム・予稿集  24th-  68  2009
• 内因性カンナビノイドによるシナプス伝達の制御

  谷村あさみ; 橋本谷祐輝; 狩野方伸  生体の科学  60-  (5)  496  -497  2009
• Synaptic plasticity in the cerebellum

  Tabata T; Kano M  Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition Neural Signaling Mechanisms  63  -86  2009  [Refereed][Invited]
  
• 発達期の小脳プルキンエ細胞におけるシナプス刈り込み：１本の“勝ち組”登上線維の樹状突起への選択的移行と“負け組”の細胞体からの除去

  橋本浩一; 狩野方伸  細胞工学  28-  1164  -1165  2009
• カンナビノイドとシナプス機能（特集：シナプス機能とその障害の分子機構）

  橋本谷祐輝; 谷村あさみ; 狩野方伸  Cognition and Dementia  8-  25  -31  2009  [Refereed][Invited]
  
• Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for long-term depression in the cerebellum

  S. Kakizawa; Y. Kishimoto; K. Hashimoto; T. Miyazaki; K. Furutani; H. Shimizu; M. Fukaya; M. Nishi; H. Sakagami; A. Ikeda; H. Kondo; M. Kano; M. Watanabe; M. Iino; H. Takeshima  JOURNAL OF NEUROCHEMISTRY  106-  50  -50  2008/07
• Molecular bases for the pruning of redundant climbing fiber-Purkinje cell synapses during postnatal cerebellar development

  橋本浩一; 狩野方伸  蛋白質核酸酵素  53-  (4)  495  -499  2008/03  [Refereed][Invited]
  
• GABA_BR-mGluR1シグナル・クロストークによる小脳LTDの増強

  上窪裕二; 上窪裕二; 田端俊英; 柿澤昌; 川上大輔; 渡辺雅彦; 飯野正光; 狩野方伸; 狩野方伸  日本薬理学雑誌  131-  (1)  2008
• Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission (vol 104, pg 16690, 2007)

  Norio Wada; Yasushi Kishimoto; Dai Watanabe; Masanobu Kano; Tomoo Hirano; Kazuo Funabiki; Shigetada Nakanishi  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  105-  (3)  1097  -1097  2008/01
• In vivo patch-clamp recordings from Purkinje cells in the developing rat cerebellum

  Yoshinobu Kawamura; Hisako Nakayama; Kazuo Kitamura; Masanobu Kano  NEUROSCIENCE RESEARCH  61-  S78  -S78  2008
• Endocannnabinoids mediate retrograde suppression at cerebellar parallel fiber to Purkinie cell synapses in young adult mice

  Asami Tanimura; Kouichi Hashimoto; Masanobu Kano  NEUROSCIENCE RESEARCH  61-  S80  -S80  2008
• Involvement of type 1 metabotoropic glutamate receptor in developmental synapse elimination in the lateral geniculate nucleus

  Madoka Narushima; Uchigashima Motokazu; Asami Tanimura; Kouichi Hashimoto; Atsu Aiba; Masahiko Watanabe; Masanobu Kano  NEUROSCIENCE RESEARCH  61-  S57  -S57  2008
• Formation of functional synapses in organotypic cocultures of the medulla and cerebellum

  Naofumi Uesaka; Masanobu Kano  NEUROSCIENCE RESEARCH  61-  S88  -S88  2008
• 長期抑圧（現代医学・生物学の仮説・学説2008）

  田端俊英; 狩野方伸  生体の科学  59-  (5)  432  -433  2008  [Refereed][Invited]
  
• 小脳におけるシナプス可塑性

  田端俊英; 狩野方伸  シリーズ 脳科学５、分子・細胞・シナプスからみる脳：甘利俊一／監修、古市貞一／編  230  -263  2008  [Refereed][Invited]
  
• シナプスの刈り込みと神経回路発達

  狩野 方伸  脳を知る・創る・守る・育む：NPO法人脳の世紀推進会議／編  125  -152  2008  [Refereed][Invited]
  
• 1P203 Hippocampal CA3 NMDA receptors network is crucial for adaptive timing and retrieval of trace conditioning(Chemoreception, neuron and sensory system, neural network, and brain computing,Oral Presentations)

  Kishimoto Yasushi; Nakazawa Kazu; Tonegawa Susumu; Kano Masanobu; Kirino Yutaka  Seibutsu Butsuri  47-  (1)  S74  2007/12  [Refereed][Invited]
  
• Molecular basis of associative eyeblink conditioning: New player involved in motor memory formation

  Yasushi Kishimoto; Yutaka Kirino; Masanobu Kano  NEUROSCIENCE RESEARCH  58-  S224  -S224  2007
• Mechanisms of endocannabinoid release and retrograde synaptic suppression in the CNS

  Masanobu Kano; Yuki Hashimotodani; Takako Ohno-Shosaku; Takashi Maejima  NEUROSCIENCE RESEARCH  58-  S10  -S10  2007
• Strength of GABAergic transmission influences climbing fiber synapse elimination during cerebellar development

  Hisako Nakayama; Kouichi Hashimoto; Taisuke Miyazaki; Yuchio Yanagawa; Kunihiko Obata; Masahiko Watanabe; Masanobu Kano  NEUROSCIENCE RESEARCH  58-  S52  -S52  2007
• The role of neural activities of thalamic and cortical neurons in thalamocortical axon branching

  Akito Yamada; Naofumi Uesaka; Yasufumi Hayano; Toshihide Tabata; Masanobu Kano; Nobuhiko Yamamoto  NEUROSCIENCE RESEARCH  58-  S89  -S89  2007
• High-threshold voltage-gated Ca2+ channels may mediate capacitive Ca2+entry in central neurons

  Toshihide Tabata; Masanobu Kano  NEUROSCIENCE RESEARCH  58-  S40  -S40  2007
• Roles of monoacylglycerol lipase in the regulation of endocannabinoid signaling

  Yuki Hashimotodani; Takako Ohno-Shosaku; Masanobu Kano  NEUROSCIENCE RESEARCH  58-  S51  -S51  2007
• Protocadherin-alpha family in the olivo-cerebellar system; their isoform expression and loss of function analysis

  You Kumode; Shun Hamada; Takashi Kitsukawa; Kouichi Hashimoto; Taisuke Miyazaki; Masanobu Kano; Masahiko Watanabe; Takeshi Yagi  NEUROSCIENCE RESEARCH  58-  S206  -S206  2007
• Junctophilin-mediated functional coupling of channels essential for cerebellar synaptic plasticity

  Sho Kakizawa; Yasushi Kishimoto; Sin-ya Saito; Kouichi Hashimoto; Taisuke Miyazaki; Kazuharu Furutani; Miyuki Nishi; Hiroyuki Sakagami; Hisatake Kondo; Masanobu Kano; Masahiko Watanabe; Masamitsu Iino; Hiroshi Takeshima  JOURNAL OF PHARMACOLOGICAL SCIENCES  103-  68P  -68P  2007
• Endogenous cannabinoid CB1 receptor is required for memory formation of cerebellum-dependent eyeblink conditioning.

  Kishimoto Yasushi; Kano Masanobu  Proceedings of Annual Meeting of the Physiological Society of Japan  2007-  (0)  72  -72  2007
• 小脳のシナプス可塑性－小脳長期抑圧とそのシグナル機構―

  田端俊英; 狩野方伸  Brain Medical  19-  27  -33  2007
• PROFILE

  狩野方伸  日本生理学雜誌 = JOURNAL OF THE PHYSIOLOGICAL SOCIETY OF JAPAN  68-  (6)  212  -213  2006/06  [Refereed][Invited]
  
• 代謝型GABA・グルタミン酸受容体の機能的相互作用と複合体化 (特集 イオンチャネル・受容体の構造機能連関研究の新たな潮流)

  田端俊英; 狩野方伸  細胞工学  25-  (3)  251  -254  2006/03  [Refereed][Invited]
  
• The mechanisms of triggering endocannabinoid release

  HASHIMOTODANI Yuki; OHNO SHOSAKU Takako; KANO Masanobu  Seikagaku. The Journal of Japanese Biochemical Society.  78-  (2)  126  -130  2006  [Refereed][Invited]
  
• Activation of NMDA receptors triggers retrograde endocannabinoid signal in hippocampal neurons

  Takako Ohno-Shosaku; Masato Ano; Yuki Hashimotodani; Tadasato Nagano; Masanobu Kano  NEUROSCIENCE RESEARCH  55-  S208  -S208  2006
• P/Q type voltage-dependent Ca2+ channel is involved in refinement of climbing fiber to Purkinje cell synapse during early postnatal development

  Kouichi Hashimoto; Masanobu Kano  NEUROSCIENCE RESEARCH  55-  S14  -S14  2006
• Roles of Endocannabinoids in Modulation of Synaptic Transmission

  KANO Masanobu; HASHIMOTODANI Yuki; MAEJIMA Takashi; OHNO SHOSAKU Takako  脂質生化学研究  47-  24  -24  2005/06
• アセチルコリンと脳内マリファナ類似物質

  狩野方伸; 少作隆子  豊田研究報告  (58)  85  -91  2005/05  [Refereed][Invited]
  
• 生後発達における小脳登上線維-Purkinje細胞シナプスの成熟 (第1土曜特集 脳科学の先端的研究--遺伝子から高次機能まで) -- (神経の発達)

  橋本浩一; 狩野方伸  医学のあゆみ  212-  (10)  891  -896  2005/03  [Refereed][Invited]
  
• Control of synaptic transmission in the CNS through endocannabinoid-mediated retrograde signaling

  Takako Ohno-Shosaku; Takashi Maejima; Takayuki Yoshida; Kouichi Hashimoto; Yuko Fukudome; Masanobu Kano  Dendritic Neurotransmitter Release  269  -281  2005  [Refereed][Invited]
  
• 小脳シナプスの機能発達と可塑性の機構

  狩野 方伸  ブレインサイエンスレビュー2005 伊藤正男・川合述史／編  83  -104  2005  [Refereed][Invited]
  
• 経験を積み重ねて作られる神経回路

  狩野 方伸  脳はどこまでわかったか：井原康夫／編  140  -158  2005  [Refereed][Invited]
  
• マリファナ類似物質の逆行性伝達物質としての役割 (特集 記憶・学習の分子基盤に迫る)

  少作隆子; 狩野方伸  Molecular Medicine  201-  (9)  1087  -1094  2004/09  [Refereed][Invited]
  
• 発達期小脳におけるシナプスの機能分化 (神経回路の機能発現のメカニズム) -- (シナプス可塑性と神経回路形成)

  橋本浩一; 狩野方伸  蛋白質核酸酵素 増刊号／神経回路の機能発現のメカニズム．大森治紀、渋木克栄、野田亮、山森哲雄／編  49-  (3)  384  -390  2004/02  [Refereed][Invited]
  
• Endocannabinoid-mediated retrograde modulation of synaptic transmission in the CNS

  M Kano; T Ohno-Shosaku  JOURNAL OF PHARMACOLOGICAL SCIENCES  94-  43P  -43P  2004
• Molecular mechanism underlying the regulation of AMPA receptor activity

  K Sakimura; M Yamazaki; T Shousaku; M Fukaya; M Kano; M Watanabe  JOURNAL OF PHARMACOLOGICAL SCIENCES  94-  64P  -64P  2004
• 内因性カンナビノイドによる逆行性シナプス伝達 (特集:21世紀の脳科学)

  狩野方伸  学術月報  56-  (4)  351  -355  2003/04  [Refereed][Invited]
  
• Endocannabinoid-mediated retrograde modulation of cerebellar synapses.

  M Kano; T Maejima; T Yoshida; M Yamasaki; K Araishi; K Hashimoto  JOURNAL OF PHARMACOLOGICAL SCIENCES  91-  13P  -13P  2003
• Suppression of inhibitory transmitter release in the hippocampus mediated directly by presynaptic and indirectly by postsynaptic metabotropic receptors.

  T Ohno-Shosaku; M Kano  JOURNAL OF PHARMACOLOGICAL SCIENCES  91-  20P  -20P  2003
• Endocannabinoid-mediated modulation of excitatory and inhibitory synaptic transmission.

  Kano M; Ohno-Shosaku T; Maejima T; Yoshida T  EXCITATORY-INHIBITORY BALANCE. Synapses, Circuits, Systems  99  -107  2003  [Refereed][Invited]
  
• 発達期小脳における登上線維シナプスの機能分化

  狩野 方伸  実験医学 増刊号／脳・神経研究2004．御子柴克彦、真鍋俊也、三浦正幸／編  21-  77  -82  2003  [Refereed][Invited]
  
• 小脳シナプスの機能発達、可塑性および機能調節におけるグルタミン酸シグナル伝達の役割

  橋本浩一; 狩野 方伸  脳血管障害による「神経細胞死」の予防と治療：川合述史／編  43  -58  2003  [Refereed][Invited]
  
• カンナビノイド受容体

  狩野 方伸  Annual Review 神経 2003  18  -24  2003  [Refereed][Invited]
  
• Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1

  Miura Masami; Watanabe Masahiko; Offermanns Stefan; Simon Melvin I; Kano Masanobu  The Journal of neuroscience : the official journal of the Society for Neuroscience  22-  (19)  8379  -8390  2002/10
• 神経・骨格筋系 グルタミン酸受容体チャネルとシナプス可塑性 (〔2002年〕6月第5土曜特集 イオンチャネルの最前線) -- (臓器でのイオンチャネルの働きと疾患)

  少作隆子; 狩野方伸  医学のあゆみ  201-  (13)  1123  -1127  2002/06  [Refereed][Invited]
  
• Local calcium signaling in dendrites required for synaptic plasticity in cerebellar Purkinje cells

  M Kano; M Miyata; K Hashimoto  JAPANESE JOURNAL OF PHARMACOLOGY  88-  9P  -9P  2002
• Trophic effect of insulin-like growth factor I on the climbing fiber-Purkinje cell synapse during postnatal development of the mouse cerebellum

  S Kakizawa; K Yamada; M Watanabe; M Kano; M Iino  JAPANESE JOURNAL OF PHARMACOLOGY  88-  203P  -203P  2002
• 小脳におけるシナプス可塑性

  狩野 方伸  シリ−ズ バイオサイエンスの新世紀 11 ／脳の発生・分化・可塑性．御子柴克彦、清水孝雄／編  11-  178  -187  2002  [Refereed][Invited]
  
• 発達脳におけるシナプス除去のメカニズム (シナプス可塑性の分子的実体)

  橋本浩一; 狩野方伸  医学のあゆみ  199-  (8)  531  -534  2001/12  [Refereed][Invited]
  
• mGluR1‐レスキューマウスを用いた小脳学習および海馬学習におけるmGluR1の機能解析

  KISHIMOTO YASUSHI; FUJIMICHI RYOKO; KAWAHARA SHIGENORI; KANO KATANOBU; KIRINO YUTAKA; AIBA ATSUSHI  日本神経科学大会プログラム・抄録集  24th-  300  2001/09
• L-serine as an astrocyte-derived essential factor for CNS neurons: a previously unrecognized role of astrocytes in brain L-serine metabolism

  S Furuya; J Mitoma; T Tabata; PM Watanabe; M Kano; Y Hirabayashi  JOURNAL OF NEUROCHEMISTRY  78-  107  -107  2001/09
• mGluR1‐レスキューマウスを用いた小脳学習および海馬学習におけるmGluR1の機能解析

  KISHIMOTO TAIJI; FUJIMICHI RYOKO; KAWAHARA SHIGETAKA; KANO MASANOBU; KIRINO YUTAKA; AIBA ATSUSHI  神経化学  40-  (2/3)  356  2001/09
• 発達期マウス小脳における代謝型グルタミン酸受容体1型の活性化により誘導されるシナプス前抑制

  前島隆司; 橋本浩一; 吉田隆之; 狩野方伸  神経化学  40-  (2/3)  439  2001/09
• 内因性カンナビノイドによる逆行性シナプス伝達調節

  少作 隆子; 前島 隆司; 水島 伊知郎; 米田 憲秀; 狩野 方伸  神経化学  40-  (2-3)  440  -440  2001/09
• 小脳シナプス可塑性の分子機構 (特集 記憶研究最近の進歩)

  橋本浩一; 狩野方伸  神経研究の進歩  45-  (2)  249  -260  2001/04  [Refereed][Invited]
  
• 遺伝子制御による選択的シナプス強化・除去機構の解明 (文部科学省S)

  井ノ口馨; 橋本浩一; 真鍋俊也; 畑裕; 溝口明; 高橋正身; 狩野方伸  科学技術振興調整費試験研究実施計画  2001-  2001
• カンナビノイド受容体と逆行性シグナル伝達

  狩野 方伸  Clinical Neuroscience  19-  1431  2001  [Refereed][Invited]
  
• 脳内カンナビノイド受容体とシナプス伝達調節

  狩野 方伸  脳の科学  23-  1000  -1002  2001  [Refereed][Invited]
  
• 小脳プルキンエ細胞におけるシナプス可塑性とカルシウム

  橋本浩一; 狩野 方伸  Clinical Calcium  11-  1432  -1439  2001
• L-Ser is a major astrocyte-derived trophic factor for cerebellar Purkinje neurons.

  S Furuya; T Tabata; J Mitoma; M Watanabe; M Kano; Y Hirabayashi  MOLECULAR BIOLOGY OF THE CELL  11-  415A  -415A  2000/12
• チロシン水酸化酵素遺伝子変異マウスにおけるノルアドレナリン神経伝達と長期記憶形成の障害

  小林和人; 野田幸裕; 松下夏樹; 西井一宏; 中原大一郎; 深堀良二; 三浦正巳; 狩野方伸; 鍋島俊隆  生化学  72-  (8)  2000
• 小脳の機能発達 (特集 小脳)

  柿澤昌; 田端俊英; 狩野方伸  神経研究の進歩  44-  (5)  713  -722  2000  [Refereed][Invited]
  
• Endogenous corticotropin-releasing factor (CRF) is required for the induction of cerebellar long-term depression

  M Kano; M Miyata; K Hashimoto; M Ito  FRONTIERS OF THE MECHANISMS OF MEMORY AND DEMENTIA  (1200)  11  -14  2000  [Refereed][Invited]
  
• Corticotropin releasing factor (CRF) induces persistent depression of parallel fiber to Purkinje cell synaptic transmission

  Miyata M; Kano M  Slow Synaptic Responses and Modulation  315  -317  2000
• Paired-pulse depression and mGluR-mediated modulation of cerebellar climbing fiber synapses

  Hashimoto K; Kano M  Slow Synaptic Responses and Modulation  268  -270  2000  [Refereed][Invited]
  
• Signal transduction cascade from mGluR1 to PKC is involved in climbing fiber synapse elimination during postnatal cerebellar development

  Kano M; Hashimoto K  Slow Synaptic Responses and Modulation  333  -340  2000  [Refereed][Invited]
  
• Synaptic development, structural modulation and gene expression. Introductory review

  Masanobu Kano  Slow Synaptic Responses and Modulation  325  -332  2000  [Refereed][Invited]
  
• 小脳

  柿澤昌; 狩野 方伸  脳神経科学イラストレイテッド 第２章 ５．森寿、真鍋俊也、渡辺雅彦、岡野栄之、宮川剛／編  70  -75  2000  [Refereed][Invited]
  
• Nonessential amino acids L-serine and glycine are astroglia-derived trophic factors for central neurons.

  S Furuya; J Mitoma; T Tabata; M Watanabe; M Kano; Y Hirabayashi  JOURNAL OF NEUROCHEMISTRY  73-  S178  -S178  1999
• Electrophysiological evidence that G alpha(q) is required for climbing fiber synapse elimination during postnatal cerebellar development

  K Hashimoto; S Offermanns; MI Simon; M Kano  NEURAL DEVELOPMENT-BOOK  2-  394  -398  1999  [Refereed][Invited]
  
• 小脳登上線維シナプス成熟に関与するシグナル伝達系

  狩野 方伸  小脳／神経科学の基礎と臨床VII．板倉徹、前田敏博／編  21  -37  1999  [Refereed][Invited]
  
• トランスジェニックマウスを用いたcell targeting法による小脳ゴルジ細胞の機能解析

  渡辺 大; 井之川 仁; 橋本 浩一; 狩野 方伸; 重本 隆一; 平野 丈夫; 外山 敬介; 金子 鋭; 横井 峰人; 森吉 弘毅  生化学  70-  (8)  998  -998  1998/08
• Possible mechanisms for climbing fiber elimination during postnatal cerebellar development

  HASHIMOTO Kouichi; KAKIZAWA Sho; KANO Masanobu  日本分子生物学会年会プログラム・講演要旨集  21-  215  -215  1998  [Refereed][Invited]
  
• Role of cerebellar lond-term depression in motor learning

  ICHISE T.; KANO M.; HASHIMOTO K.; YANAGIHARA D.; NAKAO K.; SHIGEMOTO R.; KATSUKI M.; AIBA A.  日本分子生物学会年会プログラム・講演要旨集  21-  650  -650  1998  [Refereed][Invited]
  
• Golgi Cell Function in Cerebellar Cortical Network

  WATANABE Dai; INOKAWA Hitoshi; HASHIMOTO Kouichi; SUZUKI Norimitsu; KANO Masanobu; SHIGEMOTO Ryuichi; HIRANO Tomoo; TOYAMA Keisuke; KANEKO Satoshi; YOKOI Mineto; MORIYOSHI Koki; SUZUKI Misao; KOBAYASHI Kazuto; NAGATSU Toshiharu; KREITMAN Robert j.; PASTAN Ira; NAKANISHI Shigetada  日本分子生物学会年会プログラム・講演要旨集  21-  651  -651  1998  [Refereed][Invited]
  
• チロシン水酸化酵素遺伝子変異マウスのノルアドレナリン代謝変動に基づく 記憶・学習機能の障害

  深堀良二; 野田幸裕; 松下夏樹; 西井一宏; 澤田浩秀; 永津俊治; 間宮隆吉; 鍋島俊隆; 中原大一郎; 三浦正己; 狩野方伸; 小林和人  日本分子生物学会年会プログラム・講演要旨集  21-  1998  [Refereed][Invited]
  
• シナプスに関するトピックスと今後の方向性

  狩野 方伸  無敵のバイオテクニカルシリ−ズ／脳・神経研究の進めかた．真鍋俊也、森寿、片山正寛／編  124  -127  1998  [Refereed][Invited]
  
• 小脳のシナプス可塑性とカルシウム

  狩野 方伸  Clinical Calcium  8-  194  -199  1998  [Refereed][Invited]
  
• シナプス伝達の可塑性と情報統合 (特集:脳・神経のメカニズム)

  狩野方伸  現代化学  320-  (320)  34  -42  1997/01  [Refereed][Invited]
  
• mGluR1およびPKCγノックアウトマウスにおける小脳登上線維シナプス成熟の異常 (特集 機能遺伝子のノックアウト)

  狩野方伸  神経研究の進歩  41-  (5)  756  -767  1997  [Refereed][Invited]
  
• Cerebellar ataxia in G alpha(q) deficient mice

  S Offermanns; M Kano; M Watanabe; Mancino, V; MI Simon  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY  355-  (4)  201  -201  1997
• 小脳登上線維シナプスの生後発達−ノックアウトマウスを用いた解析

  橋本浩一; 狩野 方伸  実験医学増刊号／脳科学の最前線．真鍋俊也、片山正寛／編  100  -107  1997  [Refereed][Invited]
  
• 小脳におけるシナプス可塑性

  狩野 方伸; 橋本浩一  実験医学増刊号／脳科学の最前線．真鍋俊也、片山正寛／編  82  -90  1997  [Refereed][Invited]
  
• 小脳のＬＴＤ

  宮田麻理子; 狩野 方伸  Bio Scirnce 用語ライブラリ−／脳神経．御子柴克彦／編  212  -213  1997  [Refereed][Invited]
  
• 小脳の運動学習とシナプス可塑性

  狩野 方伸  神経精神薬理  19-  1137  -1143  1997  [Refereed][Invited]
  
• 小脳の長期抑圧

  宮田麻理子; 狩野 方伸  Clinical Neuroscience  15-  1093  -1095  1997  [Refereed][Invited]
  
• 小脳シナプス可塑性と運動 : ノックアウトマウスを用いた研究

  狩野方伸  神経化学  35-  (3)  180  -181  1996/09  [Refereed][Invited]
  
• IMPAIRED SYNAPSE ELIMINATION DURING CEREBELLAR DEVELOPMENT IN PKC_ν AND mGluRl MUTANT MICE.

  KANO Masanobu  日本分子生物学会年会プログラム・講演要旨集  19-  12  -12  1996/08
• Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in PKC gamma mutant mice

  M Kano  GENE TARGETING AND NEW DEVELOPMENTS IN NEUROBIOLOGY  (19)  25  -35  1996  [Refereed][Invited]
  
• Cerebellar long-term depression and motor learning: A study on mGluR1 mutant mice

  M Kano; A Aiba; C Chen; ME Stanton; GD Fox; S Tonegawa  BRAIN PROCESSES AND MEMORY  1108-  259  -268  1996  [Refereed][Invited]
  
• 運動の記憶と小脳

  狩野 方伸  脳研究の最前線：遺伝子から知能へ． 第10回 大学と科学公開シンポジウム組織委員会編  46  -57  1996  [Refereed][Invited]
  
• グルタミン酸レセプター

  狩野方伸  Clin Neurosci  13-  548  -553  1995  [Refereed][Invited]
  
• 小脳プルキンエ細胞における抑制性シナプスの長期増強

  狩野 方伸  ブレインサイエンス最前線  95-  22  -33  1995  [Refereed][Invited]
  
• REBOUND POTENTIATION OF GABA-MEDIATED INHIBITORY SYNAPTIC CURRENTS FOLLOWING CLIMBING FIBER STIMULATION IN CEREBELLAR PURKINJE-CELLS

  M KANO; U REXHAUSEN; J DREESSEN; A KONNERTH  EUROPEAN JOURNAL OF NEUROSCIENCE  73  -73  1992
• Cerebellar slices for patch clamp recording

  Kano M; Konnerth A  Practical electrophysiological methods  54  -57  1992  [Refereed][Invited]
  
• Optokinetic responses of Purkinje cells in the rabbit's nodulus --- the zonal organization

  Maekawa K; Kano M; Kano M-S  Vestibular and brain stem control of eye, head and body movements.  339  -349  1991  [Refereed][Invited]
  
• Collateralized climbing fiber projection to the flocculus and nodulus of the rabbit

  Maekawa K; Takeda T; Kano M; Kusunoki M  The olivocerebellar system in motor control. Exp. Brain Res.Series  17-  30  -45  1989  [Refereed][Invited]
  
• 記憶の基礎過程としての海馬長期増強の維持機構

  狩野 方伸  実験医学  7-  66  -69  1989  [Refereed][Invited]
  

Awards & Honors

• 2023/03 The Japan Academy Japan Academy Prize
   Studies on Activity-Dependent Functional Adjustment of Neural Circuits 

  受賞者: Masanobu Kano
• 2018/11 The Japan Medical Association Medical Award of The Japan Medical Association
   

  受賞者: Masanobu Kano
• 2015/11 Purple Ribbon
   

  受賞者: Masanobu Kano
• 2015/03 The Uehara Memorial Foundation The Uehara Prize
   

  受賞者: 狩野 方伸
• 2011/09 The Japan Neuroscience Society Toshihiko Tokizane Memorial Award for Excellent Graduate Study in Neuroscience
   

  受賞者: Masanobu Kano
• 2005/02 Inoue Foundation for Science Inoue Prize for Science
   

  受賞者: Masanobu Kano
• 2002/07 Brain Science Foundation Tsukahara Nakaakira Memorial Award
   

  受賞者: Masanobu Kano
• 1992/09 東京医科歯科大学医科同窓会 お茶の水会医科同窓会研究奨励賞
   

  受賞者: 狩野 方伸
• 1987/02 Inoue Foundation for Science Inoue Research Award for Young Scientists
   

  受賞者: Masanobu Kano

Research Grants & Projects

• Studies on critical periods of synapse pruning in the developing cerebellum

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2020/11 -2025/03 

  Author : 狩野 方伸
• Inducing lifelong plasticity (iPlasticity) by brain rejuvenation: elucidation and manipulation of critical period mechanisms

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2020/11 -2025/03 

  Author : 狩野 方伸; 牛場 潤一; 金丸 隆志; 内ヶ島 基政; 高橋 琢哉; 辻 晶; 大木 研一; ヘンシュ 貴雄; 宮田 麻理子
• Inducing lifelong plasticity (iPlasticity) by brain rejuvenation: elucidation and manipulation of critical period mechanisms

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2020/11 -2025/03 

  Author : 狩野 方伸
• Influence of altered synapse pruning in the developing cerebellum on mouse behaviors relevant to autism spectrum disorder and schizophrenia

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2021/04 -2024/03 

  Author : 狩野 方伸
• 発達脳のシナプス刈り込みにおけるシンギュラリティ現象のイメージング解析

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2019/04 -2021/03 

  Author : 狩野 方伸
• ヒストン修飾異常に起因する精神病態のマルチスケール解析による構成的理解

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2019/04 -2021/03 

  Author : 狩野 方伸
• Epigenetic regulation of developmental synapse elimination

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2018/04 -2021/03 

  Author : Kano Masanobu
• 生命科学連携推進協議会

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2016 -2021 

  Author : 井上 純一郎; 今井 浩三; 小原 雄治; 狩野 方伸; 井本 敬二; 山本 正幸; 上野 直人; 鍋倉 淳一; 中村 卓郎; 井上 純一郎; 高田 昌彦; 若井 建志; 村上 善則; 村山 繁雄; 加藤 和人; 田中 英夫
• 先端バイオイメージング支援プラットフォーム

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2016 -2021 

  Author : 狩野 方伸; 上野 直人; 丸山 めぐみ; 真野 昌二; 菅谷 佑樹; 平岡 泰; 島貫 瑞樹; 宮澤 淳夫; 今村 健志; 野中 茂紀; 藤森 俊彦; 松田 道行; 鍋倉 淳一; 稲葉 一男; 東山 哲也; 根本 知己; 岡田 康志; 古田 寿昭; 光岡 薫; 坂本 浩隆; 中村 桂一郎; 小池 正人; 古瀬 幹夫; 深澤 有吾; 渡辺 雅彦; 青木 茂樹; 定藤 規弘; 笠井 清登; 内田 誠一; 安永 卓生; 馳澤 盛一郎; 檜垣 匠; 木森 義隆
• シナプスにおける逆行性シグナルが生後発達期の機能的神経回路形成に果たす役割の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2013 -2018 

  Author : 狩野 方伸; 崎村 建司; 少作 隆子; 橋本 浩一
• Molecular-anatomical research on multi-modal regulation of synaptic transmission in higher brain regions

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/05 -2017/03 

  Author : WATANABE MASAHIKO; Yamasaki Miwako; Miyazaki Taisuke; Konno Kohtarou; Uchigashima Motokazu; Kano Masanobu; Shigemoto Ryuichi; Kobayashi Kazuto
• Comprehensive Brain Science Network

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2010/04 -2016/03 

  Author : Kimura Minoru; Tanji Jun; Takada Masahiko; Nakamura Katsuki; Ohtsuka Toshihisa; Aoki Shigeki; Takao Hidemasa; Shimoji Keigo; Goto Masami; Yoshiura Takashi; Nakata Yasuhiro; Abe Osamu; Masumoto Tomohiko; Tokumaru Aya; Matsumura Akira; Kirino Eiji; Terada Hitoshi; Sato Noriko; Kasai Kiyoto; Hashimoto Ryota; Niwa Shin-ichi; Kato Tadafumi; Suzuki Michio; Shuji Iritani; Nemoto Kiyotaka; Tomita Hiroaki; Murayama Shigeo; Akatsu Hiroyasu; Takao Masaki; Saito Yuko; Bito Haruhiko; Yoshimura Yumiko; Matsuzaki Masanori; Furuta Toshiaki; Okado Haruo; Saito Izumu; Kaibuchi Kozo; Hasegawa Masato; Aiba Atsu; Shiina Nobuyuki; Igarashi Michihiro; Tomoki Nishioka; Watanabe Masahiko; Koike Masato; Sakagami Hiroyuki; Shigemoto Ryuichi; Fukazawa Yugo; Sakimura Kenji; Mori Hisashi; Mishina Masayoshi; Kobayashi Kazuto; Yanagawa Yuchio; Uemura Tadashi; Ishihara Takeshi; Nose Akinao; Iino Yuichi; Miyakawa Tsuyoshi; Takao Keizo; Mushiake Hajime; Katayama Norihiro; Tanaka Tetsu; Inoue Kazuhide; Okabe Shigeo; Kano Masanobu; Fujiyama Fumino; Isa Tadashi; Kageyama Ryoichiro; Fujita Ichiro; Yoshida Akira; Nishikawa Toru; Nukina Nobuyuki; Fukai Tomoki; Iwatsubo Takeshi; Yamamori Tetsuo; Okazawa Hitoshi; Tanaka Keiji; Kakigi Ryusuke; Tsuda Ichiro; Kitazawa Shigeru; Doya Kenji; Takahashi Ryosuke; Ikenaka Kazuhiro; Sobue Gen; Hasegawa Toshikazu; Ota Jun; Saitoe Minoru; Kadomatsu Kenji; Kida Satoshi; Manabe Toshiya; Tomita Taisuke; Iwata Atsushi; Murakami Ikuya; Tsutsui Ken-ichiro; Hanakawa Takashi; Hirai Hirokazu; Mima Tatsuya; Isomura Yoshikazu; Samejima Kazuyuki; Hoshi Eiji; Miyata Mariko; Yuzaki Michisuke; Tanaka Masaki; Fukata Masaki; Suzuki Kyoko; Kuba Hiroshi; Masu Masayuki; Kinoshita Makoto; Sugihara Izumi; Shirane Michiko; Yamamoto Nobuhiko; Nishijo Hisao; Nambu Atsushi; Takumi Toru; Yamashita Toshihide; Sakurai Takeshi; Tamamaki Nobuaki; Hata Yoshio; Harada Akihiro; Ozaki Norio; Sakai Katsuyuki; Kubo Yoshihiro; Nakazawa Takanobu; Tanaka Kenji; Takei Nobuyuki; Hitoshi Seiji; Takahiroa. Kato; Kato Fusao; Shirao Tomoaki; Taira Masato; Okano Hideyuki; Sekino Yuko; Okamoto Yasumasa; KOMATSU Hidehiko; Miyata Takaki; Takahashi Yoshiko; Nishida Shinya; Tominaga Makoto
• 分界条床核における内因性カンナビノイドを介するシナプス伝達修飾に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2012/04 -2015/03 

  Author : 狩野 方伸; KATO Ako; KATO AKO
• 2-アラキドノイルグリセロールによるシナプス伝達調節とその異常

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2013/04 -2014/03 

  Author : 狩野 方伸
• 活動性の高いニューロンへの光穿孔による選択的遺伝子導入

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2013/04 -2014/03 

  Author : 狩野 方伸
• 内因性カンナビノイドによる逆行性シナプス伝達の脳機能・脳病態における役割の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2009/05 -2014/03 

  Author : 狩野 方伸; 崎村 建司; 少作 隆子; 岸本 泰司
• Molecular basis for development of topographic cortico-basal ganglia circuit

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011 -2012 

  Author : HOSHINA Naosuke; YAMAMOTO Tadashi; NAKAZAWA Takanobu; KANO Masanobu; WATANABE Masahiko; KOBAYASHI Kazuto; TAKADA Masahiko; HIRANO Shinji
• Targeted gene expression in single neurons by opto-poration in vivo

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011 -2012 

  Author : KANO Masanobu
• Spatial-temporal structure of synaptic inputs-large-scale spine imaging study-

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011 -2011 

  Author : TAKAHASHI Naoya; KITAMURA Kazuo; MATSUO Naoki; KANO Masanobu; MATSUKI Norio; IKEGAYA Yuji
• Glutamate receptor dynamism in the brain functions and diseases

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2009 -2011 

  Author : SAKIMURA Kenji; NATSUME Rie; ABE Manabu; YAMAZAKI Maya; WATANABE Masahiko; KANO Masanobu
• Molecular mechanisms for calcium-mediated refinement of competitive synaptic wiring in the brain

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2007 -2011 

  Author : WATANABE Masahiko; SAKIMURA Kenji; KANO Masanobu; AIBA Atsu; FUKAYA Masahiro; YAMASAKI Miwako; MIYAZAKI Taisuke; KANO Masanobu; AIBA Atsu; FUKAYA Masahiro; YAMASAKI Miwako; MIYAZAKI Taisuke
• Integrative Brain Research

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2010 -2010 

  Author : TANJI Jun; SUZUKI Kyoko; DOYA Kenji; HENSCH Takao; ISA Tadashi; TAKADA Masahiro
• 発達期中枢神経系シナプスの選択的強化・除去過程のリアルタイムイメージング

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2009 -2010 

  Author : 狩野 方伸
• Elucidation of neural network function in the brain

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2004 -2010 

  Author : KANO Masanobu; IGARASHI Michihiro; MANABE Toshiya; OHMORI Harunori; WATANABE Wasahiko
• Studies on activity-dependent maturation of synaptic function during postnatal cerebellar development

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2005 -2009 

  Author : KANO Masanobu; SAKIMURA Kenji; OKABE Shigeo
• Elucidation of the mechanisms and physiological significance of endocannabinoid-mediated retrograde synaptic modulation

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2005 -2008 

  Author : KANO Masanobu; SAKIMURA Kenji; SHOSAKU Takako
• Identification of the endocannabinoid working as a retrograde messenger and its release mechanism

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2003 -2005 

  Author : SHOSAKU Takako; KANO Masanobu
• Molecular mechanisms for competitive synaptic wiring in cerebellar Purlfinje cells

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2002 -2004 

  Author : WATANABE Masahiko; FUKUYA Masahiro; KANO Masanobu
• Mode of action and physiological significance of endogenous cannabinoids as a retrograde messenger at central synapses

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2001 -2004 

  Author : KANO Masanobu; SHOSAKU Takako; TABATA Toshihide
• 発達脳におけるシナプス除去と機能成熟に関与するシグナル伝達系

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2000 -2004 

  Author : 狩野 方伸; 田端 俊英
• 発達期小脳における選択的シナプス強化・除去に関与する新たな遺伝子と機能分子の探索

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2000 -2003 

  Author : 狩野 方伸; 井ノ口 馨; 田端 俊英; 橋本 浩一
• 小脳特異的な低域値型カルシウムチャネルノックアウトマウスの作製と機能解析

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2001 -2002 

  Author : 狩野 方伸
• 発達期の中枢神経系におけるシナプス除去機構:In-vitroアプローチによる研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2001 -2002 

  Author : 田端 俊英; 狩野 方伸
• 人工神経回路を用いた小脳シナプス淘汰の研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1999 -2000 

  Author : 狩野 方伸; 田端 俊英
• Molecular Mechanisms for Activity-dependent Elimination of Supernumerary Excitatory Synapses in Developing Cerebellum

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1998 -1999 

  Author : KANO Masanobu; TABATA Toshihide; HASHIMOTO Kouichi
• 発達期小脳における登上線維シナプス除去の臨界期と神経活動依存症に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1998 -1998 

  Author : 狩野 方伸
• Synaptic receptors and plasticity

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1995 -1998 

  Author : MISHINA Masayoshi; WATANABE Masahiko; UMEMORI Hisashi; YAGI Takeshi; KANO Masanobu; MANABE Toshiya
• 脳由来神経栄養因子(BDNF)の小脳シナプス形成および伝達に対する作用

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1997 -1997 

  Author : 狩野 方伸
• Moleculare Mechanisms of Synapse Elimination and Stabilization in Developing Brain

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1996 -1997 

  Author : KANO Masanobu
• Identification of signal transduction cascades involved in long-lasting potentiation of inhibitory synapses

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 1993 -1995 

  Author : KANO Masanobu
• 小脳プルキンエ細胞における抑制性シナプス長期増強の分子機構の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1994 -1994 

  Author : 狩野 方伸
• 小脳プルキンエ細胞GABA受容体のセカンドメッセンジャーによる修飾機構の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1994 -1994 

  Author : 狩野 方伸
• 小脳プルキンエ細胞における抑制性シナプス長期増強の分子機構の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1993 -1993 

  Author : 狩野 方伸
• 小脳プルキンエ細胞GABA受容体のセカンドメッセンジャーによる修飾機構の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1993 -1993 

  Author : 狩野 方伸
• 感覚神経損傷後に起こる大脳体性感覚野ニューロン受容野の変化の機構に関する研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1990 -1990 

  Author : 狩野 方伸
• 視床前腹側核-外側腹側核細胞のグルタミン酸受容体の分類

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 1987 -1987 

  Author : 狩野 方伸